id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351440-vtf3o5ml	Zhang, Tianshu	COVID-19-Associated Acute Multi-infarct Encephalopathy in an Asymptomatic CADASIL Patient	2020-10-06		.txt	text/plain	1599	92	47	The chronological changes from the initial DWI and ADC images to the disappearance of these signals in the follow-up MRI support that the patient had acute subcortical ischemic changes or necrotic changes. The brain MRI showed multiple DWI lesions and corresponding ADC sequence changes which were consistent with multiple acute infarcts possibly related to hypoxic-ischemic injury from systemic perturbations and resultant tissue hypoxia. The distribution of the CT and MRI changes in our case is similar to a recent case report of acute hemorrhagic necrotizing encephalopathy in a COVID-19 patient [3] , which case, to our knowledge, was not tested for a pathological NOTCH3 mutation. The clinical features and CT and MRI changes are consistent with acute subcortical multiple infarctions which could be related to or provoked by a viral infection. Our described case is an atypical presentation of an acute COVID-19 infection in a previously asymptomatic CADASIL patient who presented with multiple infarcts and encephalopathy.	./cache/cord-351440-vtf3o5ml.txt	./txt/cord-351440-vtf3o5ml.txt