id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306516-5t3ix35e	Li, Minghui	Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis	2016-10-15		.txt	text/plain	3749	276	52	RESULTS: Calpastatin overexpression ameliorated myocardial injury induced by CVB3 infection significantly in transgenic mouse indicated by reduced peripheral CK-MB and cTnI levels and improved histology injury. In the transgenic mouse's heart, calpain inhibition was accompanied with significant perforin down-regulation post virus infection (Fig. 3B) . This study, utilizing a calpastatin-overexpression transgenic mouse model of viral myocarditis, demonstrated that endogenous calpain inhibition ameliorated myocardial injury significantly. In our former study, we found that CVB3-induced calpain activation facilitates the progeny virus replication in the early phase of infection in vitro [6] . We presented here in CVB3-induced myocarditis model that myocardium inflammation infiltration was significantly ameliorated in transgenic mouse, as well as the inflammation factors of MPO activity, IL17, perforin and IFNγ. Coxsackievirus B3-induced calpain activation facilitates the progeny virus replication via a likely mechanism related with both autophagy enhancement and apoptosis inhibition in the early phase of infection: an in vitro study in H9c2 cells	./cache/cord-306516-5t3ix35e.txt	./txt/cord-306516-5t3ix35e.txt