id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287527-ep6ug9c3	Algaissi, Abdullah	Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease	2018-09-26		.txt	text/plain	4721	231	53	title: Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease Specifically, we determined values of 50% lethal dose (LD(50)) of MERS-CoV for the 2 strains of mice, compared and correlated their levels of soluble (s)hDPP4 expression to susceptibility, and explored recombinant (r)shDPP4 as an effective MCM for MERS infection. ELISA-based and Vero E6 cell-based microneutralization assays, previously described [7] , were used to determine the titers of MERS-CoV RBD-specific serum IgG and neutralizing antibodies in hDPP4 Tg mice in response to MERS-CoV infection. Finally, we showed that administration with functionally active rhsDPP4 proteins (Figure 3 ) enabled hDPP4 +/− mice to better resist MERS-CoV infection in a dose-dependent manner (Table 1) , a finding in accordance with increased levels of shDPP4 in their circulation.	./cache/cord-287527-ep6ug9c3.txt	./txt/cord-287527-ep6ug9c3.txt