id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017521-z9l9c83i	Kubota, Tetsuya	Cuff-Induced Neointimal Formation in Mouse Models	2015-11-05		.txt	text/plain	6797	341	40	Neointimal formation consisted largely of SMC-like cells, similar to the case in the polyethylene cuff-induced injury. Mice overexpressing the murine HAS2 gene specifically in the vascular SMCs (cHAS2/CreSM22a mice) showed markedly enhanced cuff-induced neointimal formation, with augmentation of SMC migration and proliferation, and production of inflammatory cytokines and ROS [39] . iNOS has been shown to be expressed in the SMCs after cuff-induced vascular injury in rabbits [57, 58] , and iNOS-KO mice showed a significant reduction of neointimal thickening induced by cuff placement [59] . Application of Pam3Cys-SK4, a synthetic Tlr2 ligand, significantly enhanced the neointimal formation induced by cuff placement in the femoral arteries of the WT mice. In fact, AT1 receptor-KO mice showed decreased neointimal formation following cuff placement, accompanied by an increase of apoptotic cells among the SMCs [74] . On the other hand, neointimal formation induced by cuff placement was increased in AT2 receptor-KO mice.	./cache/cord-017521-z9l9c83i.txt	./txt/cord-017521-z9l9c83i.txt