id author title date pages extension mime words sentences flesch summary cache txt cord-013023-uanozm00 Crouse, Richard B Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency 2020-09-18 .txt text/plain 13289 617 50 We then optically stimulated cholinergic NBM fibers locally in the BLA, while mice learned to nose poke in response to an auditory cue to receive a food reward to determine if accelerating the increase in ACh signaling that occurs as mice learn the task would enhance performance. As in the previous experiment, there were no differences between the EYFP control (n = 6) and stimulation groups (contingent-ChR2 n = 5 and non-contingent ChR2 n = 5) during Pre-Training ( Figure These results demonstrate that ChR2-mediated ACh release does not have to be time-locked to the cue, nose poke, or reward retrieval to improve performance of the task, suggesting that ACh may alter the threshold for neuronal plasticity for cue-reward pairing over a much longer timescale than might be expected based on results from the ACh3.0 recording and NBM-BLA recordings, which could be consistent with the involvement of mAChR signaling in this effect. ./cache/cord-013023-uanozm00.txt ./txt/cord-013023-uanozm00.txt