id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001569-jd028cyg	dos Santos, Gimena	Vimentin regulates activation of the NLRP3 inflammasome	2015-03-12		.txt	text/plain	8469	459	48	We demonstrate that central pathophysiologic events in ALI (inflammation, IL-1β levels, endothelial and alveolar epithelial barrier permeability, remodelling and fibrosis) are attenuated in the lungs of Vim(−/−) mice challenged with LPS, bleomycin and asbestos. Exposure to bleomycin resulted in a large increase in immune cells in the airspace of both WT and Vim À / À mice as assessed by flow cytometric analysis of whole-lung lysates ( Supplementary Fig. 3a ). All together, these results suggest that vimentin-expressing bone marrow-derived cells are important for bleomycin-induced activation of the NLRP3 inflammasome and pulmonary fibrosis. Studies with IL-1R1 À / À , MyD88 À / À , ASC À / À , Caspase-1 À / À and NLRP3 À / À mice have suggested that uric acid (induced by bleomycin), asbestos and silica are detected by the NLRP3 inflammasome in macrophages, likely leading to IL-1R1/MyD88 signalling in pulmonary epithelial cells, then to inflammation, neutrophil and lymphocyte recruitment and fibroblast activation 35 .	./cache/cord-001569-jd028cyg.txt	./txt/cord-001569-jd028cyg.txt