id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329514-dnh3rx0q	Kurono, Yuichi	Middle Ear and Eustachian Tube	2007-05-09		.txt	text/plain	5326	296	42	Although specific IgG antibodies are protective against the invasion of bacterial antigen into the middle ear, some evidence suggests that systemic immune system may be involved in inducing or sustaining MEEs. Ueyama et al. The presence of antigen-specific IgA antibodies in MEEs of patients with AOM as well as OME suggests that the mucosal immune system in the middle ear plays a role in the pathogenesis of those diseases. (1996) also reported that parenteral immunization with P6 did not alter the extent or duration of nasopharyngeal colonization by NTHi. These results indicate that IgA antibodies in nasopharyngeal secretions inhibit the adherence of middle ear pathogens to nasopharyngeal mucosa and facilitate the clearance of those bacteria from the nasopharynx. Induction of specific immunoglobulin A and Th2 immune responses to P6 outer membrane protein of nontypeable Haemophilus influenzae in middle ear mucosa by intranasal immunization	./cache/cord-329514-dnh3rx0q.txt	./txt/cord-329514-dnh3rx0q.txt