id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318585-cp76qr9f	Matsuyama, Ryota	Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis	2016-11-29		.txt	text/plain	4498	217	48	BACKGROUND: While the risk of severe complications of Middle East respiratory syndrome (MERS) and its determinants have been explored in previous studies, a systematic analysis of published articles with different designs and populations has yet to be conducted. We identified older age, male sex and underlying medical conditions, including diabetes mellitus, renal disease, respiratory disease, heart disease and hypertension, as clinical predictors of death associated with MERS. PICO statement: Our study question is focused on laboratory confirmed cases of MERS regardless of their treatment status, and thus, involves only retrospective observational studies, measuring their risks of admission to Intensive Care Unit (ICU) and death and comparing those risks by age, gender and underlying comorbidities. The present study systematically reviewed the risk of severe manifestations and death by MERS by systematically searching and analyzing published articles from the KSA and the ROK and calculating not only the CFR but [16] . For Fig. 4 Estimated risks associated with Middle East respiratory syndrome (MERS) by study design.	./cache/cord-318585-cp76qr9f.txt	./txt/cord-318585-cp76qr9f.txt