id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334499-fz7vrnb1	Templeton, Steven P.	Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM	2007-06-01		.txt	text/plain	6288	297	37	Infection of mice with variants of mouse hepatitis virus, strain JHM (MHV-JHM), provide models of acute and chronic viral infection of the central nervous system (CNS). Partially protective anti-viral immune responses may result in persistent infection and chronic demyelinating disease characterized by myelin removal from axons of the CNS and associated with dense macrophage/microglial infiltration. Demyelinating disease during MHV-JHM infection is immune-mediated, as mice that lack T lymphocytes fail to develop disease despite succumbing to encephalitis with high levels of infectious virus in the CNS. Demyelinating disease induced during MHV-JHM infection is partly immune mediated, as mice lacking the ability to generate T cell responses fail to develop demyelination, despite high viral loads and widespread inflammation in the CNS of infected mice [19, 20] . Further studies involve introduction of other chemoattractants into recombinant MHV-JHM, to evaluate their role in demyelinating disease, cell recruitment, generation of immune responses, and clearance of infectious virus in MHV-JHM-infected mice.	./cache/cord-334499-fz7vrnb1.txt	./txt/cord-334499-fz7vrnb1.txt