id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331267-j9ld7q70	Wu, Z. G.	Telbivudine preserves T‐helper 1 cytokine production and downregulates programmed death ligand 1 in a mouse model of viral hepatitis	2010-03-03		.txt	text/plain	4232	210	42	The effects of telbivudine on virus replication and cytokine production were investigated in vitro using MHV‐3‐infected macrophages, and the effects on T‐cell response were investigated in vivo in an MHV‐3‐induced viral hepatitis model. The aims of the present study were to characterize the effects of telbivudine on cytokine profile and T-cell response in vitro and in vivo using a previously characterized mouse model of viral hepatitis induced by the coronavirus mouse hepatitis virus strain 3 (MHV-3) [18, 19] . Cytokine level measurement by PCR and enzyme-linked immunosorbent assay To determine the effect of telbivudine on tumour necrosis factor (TNF)-a and interleukin (IL)-12 cytokine production, one million macrophages from BALB/cJ mice were stimulated with MHV-3 (multiplicity of infection, 2.5) and telbivudine was added at indicated concentrations. In summary, the present study demonstrates that the beneficial effects of telbivudine in MHV-3-induced hepatitis may be mediated by its effect on the immune response rather than the inhibition of viral replication in this animal model.	./cache/cord-331267-j9ld7q70.txt	./txt/cord-331267-j9ld7q70.txt