id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276198-psjua913	V’kovski, Philip	New insights on the role of paired membrane structures in coronavirus replication	2015-04-16		.txt	text/plain	6083	303	44	Many nidovirus and all coronavirus TM1 proteins contain one or more ubiquitin-like domains which may help to anchor the viral RNA to the membranes where replication takes place (Hurst et al., 2013) . The maze-like paired-membrane structures that resulted from coexpression of SARS-CoV TM1 and TM2 have not ever been reported in coronavirus-infected cells, suggesting that this should be interpreted as a conditional, or perhaps partial phenotype, that is not observed when the full viral replicase polyprotein is expressed. Since DMVs are reminiscent of the double-membranes of autophagosomes, several lines of controversial evidence hypothesized a diversion of Atg (autophagyrelated) proteins and autophagosome function during coronavirus replication, as it is the case for other +RNA viruses (Prentice et al., 2004; Snijder et al., 2006; Zhao et al., 2007; Maier and Britton, 2012; Richards and Jackson, 2013) . Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex	./cache/cord-276198-psjua913.txt	./txt/cord-276198-psjua913.txt