id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017613-va4ft5we	Taguchi, Fumihiro	Coronavirus Receptors	2005		.txt	text/plain	2994	143	49	The major receptor for murine coronavirus, mouse hepatitis virus (MHV), is identified as a protein, cell-adhesion molecule 1 in the carcinoembryonic antigen family (CEACAM1), which is classified in the immunoglobulin superfamily. This domain is also responsible for binding to the MHV spike (S) protein; the CC' face protruding in this domain interacts with an N terminal region of the S protein composed of 330 amino acids (called S1N330). found that the plasma membranes isolated from MHV-susceptible BALB/c mouse hepatocytes or enterocytes contained a 110 to 120-kDa protein that binds to MHV particles, but those derived from MHV-resistant SJL mice lacked such a protein (2). Although CEACAM1 consisting of N domain alone bound MHV, it did not work as a functional receptor when expressed on CEACAMl-negative cells (18) . Communication between S1N330 and a region in $2 of murine coronavirus spike protein is important for virus entry into cells expressing CEACAM I b receptor	./cache/cord-017613-va4ft5we.txt	./txt/cord-017613-va4ft5we.txt