id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009821-19dxy56e	van Berlo, M.F.	Vulnerability of rat and mouse brain cells to murine hepatitis virus (JHM‐strain): Studies in vivo and in vitro	2004-10-12		.txt	text/plain	3890	228	54	The present study examined the effects of MHV-JHM on cultured brain cells derived from Balb/c mice and from Wistar and from Lewis rats. To study the infection of astrocytes with MHV-JHM in vitro, cultures of brain cells derived from either newborn mice or rats were prepared and infected with virus. Infection of these oligodendrocyte-enriched cultures with MHV-JHM showed that 1 day after infection only a few GalC-positive (Fig. 4A,B) and no A2B5-positive cells (results not shown) contained viral proteins. When MHV-JHM infection caused an acute encephalitis in young rat pups, antigen could be found throughout the brain, mainly in astrocytes (Fig. 1A,B) . This susceptibility to MHV-JHM infection is found also in cultures of mouse astrocytes and Lewis rats (Massa et al., 1986) . Analysis of murine hepatitis virus (JHM strain) tropism toward Lewis rat glia cells in vitro: Type 1 astrocytes and brain macrophages (microglia) a s primary glial cell targets	./cache/cord-009821-19dxy56e.txt	./txt/cord-009821-19dxy56e.txt