id author title date pages extension mime words sentences flesch summary cache txt cord-004663-a47pkh8q Tardieu, M. Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3) 1982 .txt text/plain 3424 219 48 title: Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3) In semisusceptible mice, infection led first to a transient meningitis, ependymitis, and leukoencephalitis, followed by a permanent communicating hydrocephalus and, later on, to a chronic thrombotic vasculitis affecting meningeal and parenchymal vessels at the brain stem level. Identical lesions occurred in fully susceptible mice infected with a low dose of virus, but no neurologic disorder could be induced in genetically resistant mice even following immunosuppression or intracranial inoculation. When six susceptible BALB/c mice were injected i.p. with MHV 3 (103LD50), they died of an acute hepatic necrosis 5 -8 d a y s after M H V 3 infection, and no neuropatholigic lesion was observed except a slight degree of meningeal infiltration. ./cache/cord-004663-a47pkh8q.txt ./txt/cord-004663-a47pkh8q.txt