id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000396-egy1d90x	Shindler, Kenneth S.	Macrophage-Mediated Optic Neuritis Induced by Retrograde Axonal Transport of Spike Gene Recombinant Mouse Hepatitis Virus	2011-06-01		.txt	text/plain	4331	193	40	Prior studies using recombinant MHV strains that differ only in the spike gene, which encodes a glycoprotein involved in virus-host cell attachment, demonstrated that spike mediates anterograde axonal transport of virus to the spinal cord. A demyelinating MHV strain induces optic neuritis, but whether this is due to retrograde axonal transport of viral particles to the retina, or if it is due to traumatic disruption of retinal ganglion cell axons during intracranial inoculation is not known. The optic nerve inflammation, demyelination, and axonal loss observed after RSA59 infection, but not after RSMHV2 infection, demonstrate that the MHV-A59 spike protein is required for the induction of optic neuritis. This differential ability of MHV strains to induce optic neuritis and axonal injury is dependent on spike glycoprotein mediated retrograde transport of viral antigen along RGC axons.	./cache/cord-000396-egy1d90x.txt	./txt/cord-000396-egy1d90x.txt