key: cord-328835-r9znjkfo
authors: Favre, Guillaume; Pomar, Léo; Musso, Didier; Baud, David
title: 2019-nCoV epidemic: what about pregnancies?
date: 2020-02-06
journal: Lancet
DOI: 10.1016/s0140-6736(20)30311-1
sha: 
doc_id: 328835
cord_uid: r9znjkfo

nan

Members of the coronavirus family responsible for severe acute respiratory syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV) are known to be responsible for severe complications during pregnancy. 2, 3 12 pregnant women were infected with SARS-CoV during the 2002-03 pandemic. 2 Four (57%) of seven women in the first trimester had a miscarriage. In the second to third trimester, two (40%) of five women had fetal growth restriction, and four (80%) of five women had preterm birth (one spontaneous; three induced for maternal condition). Three (25%) women died during pregnancy.

In a review of 11 pregnant women infected with MERS-CoV, 3 ten (91%) presented with adverse outcomes, six (55%) neonates required admission to the intensive care unit, and three (27%) died. Two neonates were delivered prematurely for severe maternal respiratory failure.

Considering that the 2019-nCoV seems to have a similar pathogenic potential as SARS-CoV and MERS-CoV, 4 pregnant women are at increased risk of severe infections, there are no specific clinical signs of coronavirus infections preceding severe complications, 5 coronaviruses have the potential to cause severe maternal or perinatal adverse outcomes, or both, 2,3 and the current lack of data on the consequences of a 2019-nCoV infection during pregnancy, we recommend systematic screening of any suspected 2019-nCoV infection during pregnancy. If 2019-nCoV infection during pregnancy is confirmed, extended followup should be recommended for mothers and their fetuses.

Situation report-14

Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome

Middle East respiratory syndrome coronavirus (MERS-CoV) infection during pregnancy: report of two cases & review of the literature

China coronavirus: what do we know so far?

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

We declare no competing interests.Guillaume Favre, Léo Pomar, Didier Musso, *David Baud