id	sid	tid	token	lemma	pos
cord-329876-4cgrjnjo	1	1	key	key	JJ
cord-329876-4cgrjnjo	2	1	:	:	:
cord-329876-4cgrjnjo	2	2	cord-329876	cord-329876	NNP
cord-329876-4cgrjnjo	2	3	-	-	HYPH
cord-329876-4cgrjnjo	2	4	4cgrjnjo	4cgrjnjo	CD
cord-329876-4cgrjnjo	2	5	authors	author	NNS
cord-329876-4cgrjnjo	2	6	:	:	:
cord-329876-4cgrjnjo	2	7	Lei	Lei	NNP
cord-329876-4cgrjnjo	2	8	,	,	,
cord-329876-4cgrjnjo	2	9	Jian	Jian	NNP
cord-329876-4cgrjnjo	2	10	;	;	:
cord-329876-4cgrjnjo	2	11	Hilgenfeld	Hilgenfeld	NNP
cord-329876-4cgrjnjo	2	12	,	,	,
cord-329876-4cgrjnjo	3	1	Rolf	Rolf	NNP
cord-329876-4cgrjnjo	3	2	title	title	NN
cord-329876-4cgrjnjo	3	3	:	:	:
cord-329876-4cgrjnjo	4	1	Structural	structural	JJ
cord-329876-4cgrjnjo	4	2	and	and	CC
cord-329876-4cgrjnjo	4	3	mutational	mutational	JJ
cord-329876-4cgrjnjo	4	4	analysis	analysis	NN
cord-329876-4cgrjnjo	4	5	of	of	IN
cord-329876-4cgrjnjo	4	6	the	the	DT
cord-329876-4cgrjnjo	4	7	interaction	interaction	NN
cord-329876-4cgrjnjo	4	8	between	between	IN
cord-329876-4cgrjnjo	4	9	the	the	DT
cord-329876-4cgrjnjo	4	10	Middle	Middle	NNP
cord-329876-4cgrjnjo	4	11	-	-	HYPH
cord-329876-4cgrjnjo	4	12	East	East	NNP
cord-329876-4cgrjnjo	4	13	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	4	14	syndrome	syndrome	NN
cord-329876-4cgrjnjo	4	15	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	4	16	(	(	-LRB-
cord-329876-4cgrjnjo	4	17	MERS	MERS	NNP
cord-329876-4cgrjnjo	4	18	-	-	HYPH
cord-329876-4cgrjnjo	4	19	CoV	CoV	NNP
cord-329876-4cgrjnjo	4	20	)	)	-RRB-
cord-329876-4cgrjnjo	4	21	papain	papain	NN
cord-329876-4cgrjnjo	4	22	-	-	HYPH
cord-329876-4cgrjnjo	4	23	like	like	JJ
cord-329876-4cgrjnjo	4	24	protease	protease	NN
cord-329876-4cgrjnjo	4	25	and	and	CC
cord-329876-4cgrjnjo	4	26	human	human	JJ
cord-329876-4cgrjnjo	4	27	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	4	28	date	date	NN
cord-329876-4cgrjnjo	4	29	:	:	:
cord-329876-4cgrjnjo	4	30	2016	2016	CD
cord-329876-4cgrjnjo	4	31	-	-	HYPH
cord-329876-4cgrjnjo	4	32	05	05	CD
cord-329876-4cgrjnjo	4	33	-	-	SYM
cord-329876-4cgrjnjo	4	34	30	30	CD
cord-329876-4cgrjnjo	4	35	journal	journal	NN
cord-329876-4cgrjnjo	4	36	:	:	:
cord-329876-4cgrjnjo	5	1	Virol	Virol	NNP
cord-329876-4cgrjnjo	6	1	Sin	sin	NN
cord-329876-4cgrjnjo	6	2	DOI	doi	NN
cord-329876-4cgrjnjo	6	3	:	:	:
cord-329876-4cgrjnjo	7	1	10.1007	10.1007	CD
cord-329876-4cgrjnjo	7	2	/	/	SYM
cord-329876-4cgrjnjo	7	3	s12250	s12250	JJ
cord-329876-4cgrjnjo	7	4	-	-	HYPH
cord-329876-4cgrjnjo	7	5	016	016	CD
cord-329876-4cgrjnjo	7	6	-	-	HYPH
cord-329876-4cgrjnjo	7	7	3742	3742	CD
cord-329876-4cgrjnjo	7	8	-	-	SYM
cord-329876-4cgrjnjo	7	9	4	4	CD
cord-329876-4cgrjnjo	7	10	sha	sha	NN
cord-329876-4cgrjnjo	7	11	:	:	:
cord-329876-4cgrjnjo	7	12	5dd0f03bb34af58c469693cf5f3e311a80d804d4	5dd0f03bb34af58c469693cf5f3e311a80d804d4	CD
cord-329876-4cgrjnjo	7	13	doc_id	doc_id	CD
cord-329876-4cgrjnjo	7	14	:	:	:
cord-329876-4cgrjnjo	7	15	329876	329876	CD
cord-329876-4cgrjnjo	7	16	cord_uid	cord_uid	NNS
cord-329876-4cgrjnjo	7	17	:	:	:
cord-329876-4cgrjnjo	7	18	4cgrjnjo	4cgrjnjo	CD
cord-329876-4cgrjnjo	8	1	The	the	DT
cord-329876-4cgrjnjo	8	2	papain	papain	NN
cord-329876-4cgrjnjo	8	3	-	-	HYPH
cord-329876-4cgrjnjo	8	4	like	like	JJ
cord-329876-4cgrjnjo	8	5	protease	protease	NN
cord-329876-4cgrjnjo	8	6	(	(	-LRB-
cord-329876-4cgrjnjo	8	7	PL(pro	pl(pro	ADD
cord-329876-4cgrjnjo	8	8	)	)	-RRB-
cord-329876-4cgrjnjo	8	9	)	)	-RRB-
cord-329876-4cgrjnjo	8	10	of	of	IN
cord-329876-4cgrjnjo	8	11	Middle	Middle	NNP
cord-329876-4cgrjnjo	8	12	-	-	HYPH
cord-329876-4cgrjnjo	8	13	East	East	NNP
cord-329876-4cgrjnjo	8	14	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	8	15	syndrome	syndrome	NN
cord-329876-4cgrjnjo	8	16	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	8	17	(	(	-LRB-
cord-329876-4cgrjnjo	8	18	MERS	MERS	NNP
cord-329876-4cgrjnjo	8	19	-	-	HYPH
cord-329876-4cgrjnjo	8	20	CoV	CoV	NNP
cord-329876-4cgrjnjo	8	21	)	)	-RRB-
cord-329876-4cgrjnjo	8	22	has	have	VBZ
cord-329876-4cgrjnjo	8	23	proteolytic	proteolytic	JJ
cord-329876-4cgrjnjo	8	24	,	,	,
cord-329876-4cgrjnjo	8	25	deubiquitinating	deubiquitinating	NN
cord-329876-4cgrjnjo	8	26	,	,	,
cord-329876-4cgrjnjo	8	27	and	and	CC
cord-329876-4cgrjnjo	8	28	deISGylating	deisgylate	VBG
cord-329876-4cgrjnjo	8	29	activities	activity	NNS
cord-329876-4cgrjnjo	8	30	.	.	.
cord-329876-4cgrjnjo	9	1	The	the	DT
cord-329876-4cgrjnjo	9	2	latter	latter	JJ
cord-329876-4cgrjnjo	9	3	two	two	CD
cord-329876-4cgrjnjo	9	4	are	be	VBP
cord-329876-4cgrjnjo	9	5	involved	involve	VBN
cord-329876-4cgrjnjo	9	6	in	in	IN
cord-329876-4cgrjnjo	9	7	the	the	DT
cord-329876-4cgrjnjo	9	8	suppression	suppression	NN
cord-329876-4cgrjnjo	9	9	of	of	IN
cord-329876-4cgrjnjo	9	10	the	the	DT
cord-329876-4cgrjnjo	9	11	antiviral	antiviral	JJ
cord-329876-4cgrjnjo	9	12	innate	innate	JJ
cord-329876-4cgrjnjo	9	13	immune	immune	JJ
cord-329876-4cgrjnjo	9	14	response	response	NN
cord-329876-4cgrjnjo	9	15	of	of	IN
cord-329876-4cgrjnjo	9	16	the	the	DT
cord-329876-4cgrjnjo	9	17	host	host	NN
cord-329876-4cgrjnjo	9	18	cell	cell	NN
cord-329876-4cgrjnjo	9	19	.	.	.
cord-329876-4cgrjnjo	10	1	To	to	TO
cord-329876-4cgrjnjo	10	2	contribute	contribute	VB
cord-329876-4cgrjnjo	10	3	to	to	IN
cord-329876-4cgrjnjo	10	4	an	an	DT
cord-329876-4cgrjnjo	10	5	understanding	understanding	NN
cord-329876-4cgrjnjo	10	6	of	of	IN
cord-329876-4cgrjnjo	10	7	this	this	DT
cord-329876-4cgrjnjo	10	8	process	process	NN
cord-329876-4cgrjnjo	10	9	,	,	,
cord-329876-4cgrjnjo	10	10	we	-PRON-	PRP
cord-329876-4cgrjnjo	10	11	present	present	VBP
cord-329876-4cgrjnjo	10	12	here	here	RB
cord-329876-4cgrjnjo	10	13	the	the	DT
cord-329876-4cgrjnjo	10	14	X	x	NN
cord-329876-4cgrjnjo	10	15	-	-	NN
cord-329876-4cgrjnjo	10	16	ray	ray	NN
cord-329876-4cgrjnjo	10	17	crystal	crystal	NN
cord-329876-4cgrjnjo	10	18	structure	structure	NN
cord-329876-4cgrjnjo	10	19	of	of	IN
cord-329876-4cgrjnjo	10	20	a	a	DT
cord-329876-4cgrjnjo	10	21	complex	complex	NN
cord-329876-4cgrjnjo	10	22	between	between	IN
cord-329876-4cgrjnjo	10	23	MERS	MERS	NNP
cord-329876-4cgrjnjo	10	24	-	-	HYPH
cord-329876-4cgrjnjo	10	25	CoV	CoV	NNP
cord-329876-4cgrjnjo	10	26	PL(pro	PL(pro	NNP
cord-329876-4cgrjnjo	10	27	)	)	-RRB-
cord-329876-4cgrjnjo	10	28	and	and	CC
cord-329876-4cgrjnjo	10	29	human	human	JJ
cord-329876-4cgrjnjo	10	30	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	10	31	(	(	-LRB-
cord-329876-4cgrjnjo	10	32	Ub	Ub	NNP
cord-329876-4cgrjnjo	10	33	)	)	-RRB-
cord-329876-4cgrjnjo	10	34	that	that	WDT
cord-329876-4cgrjnjo	10	35	is	be	VBZ
cord-329876-4cgrjnjo	10	36	devoid	devoid	JJ
cord-329876-4cgrjnjo	10	37	of	of	IN
cord-329876-4cgrjnjo	10	38	any	any	DT
cord-329876-4cgrjnjo	10	39	covalent	covalent	JJ
cord-329876-4cgrjnjo	10	40	linkage	linkage	NN
cord-329876-4cgrjnjo	10	41	between	between	IN
cord-329876-4cgrjnjo	10	42	the	the	DT
cord-329876-4cgrjnjo	10	43	two	two	CD
cord-329876-4cgrjnjo	10	44	proteins	protein	NNS
cord-329876-4cgrjnjo	10	45	.	.	.
cord-329876-4cgrjnjo	11	1	Five	five	CD
cord-329876-4cgrjnjo	11	2	regions	region	NNS
cord-329876-4cgrjnjo	11	3	of	of	IN
cord-329876-4cgrjnjo	11	4	the	the	DT
cord-329876-4cgrjnjo	11	5	PL(pro	pl(pro	ADD
cord-329876-4cgrjnjo	11	6	)	)	-RRB-
cord-329876-4cgrjnjo	11	7	bind	bind	VBP
cord-329876-4cgrjnjo	11	8	to	to	IN
cord-329876-4cgrjnjo	11	9	two	two	CD
cord-329876-4cgrjnjo	11	10	areas	area	NNS
cord-329876-4cgrjnjo	11	11	of	of	IN
cord-329876-4cgrjnjo	11	12	the	the	DT
cord-329876-4cgrjnjo	11	13	Ub	Ub	NNP
cord-329876-4cgrjnjo	11	14	.	.	.
cord-329876-4cgrjnjo	12	1	The	the	DT
cord-329876-4cgrjnjo	12	2	C	C	NNP
cord-329876-4cgrjnjo	12	3	-	-	HYPH
cord-329876-4cgrjnjo	12	4	terminal	terminal	NN
cord-329876-4cgrjnjo	12	5	five	five	CD
cord-329876-4cgrjnjo	12	6	residues	residue	NNS
cord-329876-4cgrjnjo	12	7	of	of	IN
cord-329876-4cgrjnjo	12	8	Ub	Ub	NNP
cord-329876-4cgrjnjo	12	9	,	,	,
cord-329876-4cgrjnjo	12	10	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	12	11	,	,	,
cord-329876-4cgrjnjo	12	12	are	be	VBP
cord-329876-4cgrjnjo	12	13	similar	similar	JJ
cord-329876-4cgrjnjo	12	14	to	to	IN
cord-329876-4cgrjnjo	12	15	the	the	DT
cord-329876-4cgrjnjo	12	16	P5–P1	P5–P1	NNP
cord-329876-4cgrjnjo	12	17	residues	residue	NNS
cord-329876-4cgrjnjo	12	18	of	of	IN
cord-329876-4cgrjnjo	12	19	the	the	DT
cord-329876-4cgrjnjo	12	20	polyprotein	polyprotein	JJ
cord-329876-4cgrjnjo	12	21	substrates	substrate	NNS
cord-329876-4cgrjnjo	12	22	of	of	IN
cord-329876-4cgrjnjo	12	23	the	the	DT
cord-329876-4cgrjnjo	12	24	PL(pro	PL(pro	NNP
cord-329876-4cgrjnjo	12	25	)	)	-RRB-
cord-329876-4cgrjnjo	12	26	and	and	CC
cord-329876-4cgrjnjo	12	27	are	be	VBP
cord-329876-4cgrjnjo	12	28	responsible	responsible	JJ
cord-329876-4cgrjnjo	12	29	for	for	IN
cord-329876-4cgrjnjo	12	30	the	the	DT
cord-329876-4cgrjnjo	12	31	major	major	JJ
cord-329876-4cgrjnjo	12	32	part	part	NN
cord-329876-4cgrjnjo	12	33	of	of	IN
cord-329876-4cgrjnjo	12	34	the	the	DT
cord-329876-4cgrjnjo	12	35	interaction	interaction	NN
cord-329876-4cgrjnjo	12	36	between	between	IN
cord-329876-4cgrjnjo	12	37	the	the	DT
cord-329876-4cgrjnjo	12	38	two	two	CD
cord-329876-4cgrjnjo	12	39	macromolecules	macromolecule	NNS
cord-329876-4cgrjnjo	12	40	.	.	.
cord-329876-4cgrjnjo	13	1	Through	through	IN
cord-329876-4cgrjnjo	13	2	sitedirected	sitedirected	JJ
cord-329876-4cgrjnjo	13	3	mutagenesis	mutagenesis	NN
cord-329876-4cgrjnjo	13	4	,	,	,
cord-329876-4cgrjnjo	13	5	we	-PRON-	PRP
cord-329876-4cgrjnjo	13	6	demonstrate	demonstrate	VBP
cord-329876-4cgrjnjo	13	7	that	that	DT
cord-329876-4cgrjnjo	13	8	conserved	conserve	VBN
cord-329876-4cgrjnjo	13	9	Asp165	Asp165	,
cord-329876-4cgrjnjo	13	10	and	and	CC
cord-329876-4cgrjnjo	13	11	non	non	JJ
cord-329876-4cgrjnjo	13	12	-	-	JJ
cord-329876-4cgrjnjo	13	13	conserved	conserved	JJ
cord-329876-4cgrjnjo	13	14	Asp164	asp164	CD
cord-329876-4cgrjnjo	13	15	are	be	VBP
cord-329876-4cgrjnjo	13	16	important	important	JJ
cord-329876-4cgrjnjo	13	17	for	for	IN
cord-329876-4cgrjnjo	13	18	the	the	DT
cord-329876-4cgrjnjo	13	19	catalytic	catalytic	JJ
cord-329876-4cgrjnjo	13	20	activities	activity	NNS
cord-329876-4cgrjnjo	13	21	of	of	IN
cord-329876-4cgrjnjo	13	22	MERS	MERS	NNP
cord-329876-4cgrjnjo	13	23	-	-	HYPH
cord-329876-4cgrjnjo	13	24	CoV	CoV	NNP
cord-329876-4cgrjnjo	13	25	PL(pro	PL(pro	NNP
cord-329876-4cgrjnjo	13	26	)	)	-RRB-
cord-329876-4cgrjnjo	13	27	.	.	.
cord-329876-4cgrjnjo	14	1	The	the	DT
cord-329876-4cgrjnjo	14	2	enzyme	enzyme	NN
cord-329876-4cgrjnjo	14	3	appears	appear	VBZ
cord-329876-4cgrjnjo	14	4	not	not	RB
cord-329876-4cgrjnjo	14	5	to	to	TO
cord-329876-4cgrjnjo	14	6	be	be	VB
cord-329876-4cgrjnjo	14	7	optimized	optimize	VBN
cord-329876-4cgrjnjo	14	8	for	for	IN
cord-329876-4cgrjnjo	14	9	catalytic	catalytic	JJ
cord-329876-4cgrjnjo	14	10	efficiency	efficiency	NN
cord-329876-4cgrjnjo	14	11	;	;	:
cord-329876-4cgrjnjo	14	12	thus	thus	RB
cord-329876-4cgrjnjo	14	13	,	,	,
cord-329876-4cgrjnjo	14	14	replacement	replacement	NN
cord-329876-4cgrjnjo	14	15	of	of	IN
cord-329876-4cgrjnjo	14	16	Phe269	phe269	CD
cord-329876-4cgrjnjo	14	17	by	by	IN
cord-329876-4cgrjnjo	14	18	Tyr	Tyr	NNP
cord-329876-4cgrjnjo	14	19	leads	lead	VBZ
cord-329876-4cgrjnjo	14	20	to	to	IN
cord-329876-4cgrjnjo	14	21	increased	increase	VBN
cord-329876-4cgrjnjo	14	22	peptidolytic	peptidolytic	JJ
cord-329876-4cgrjnjo	14	23	and	and	CC
cord-329876-4cgrjnjo	14	24	deubiquitinating	deubiquitinating	NN
cord-329876-4cgrjnjo	14	25	activities	activity	NNS
cord-329876-4cgrjnjo	14	26	.	.	.
cord-329876-4cgrjnjo	15	1	Ubiquitin	Ubiquitin	NNP
cord-329876-4cgrjnjo	15	2	binding	bind	VBG
cord-329876-4cgrjnjo	15	3	by	by	IN
cord-329876-4cgrjnjo	15	4	MERS	MERS	NNP
cord-329876-4cgrjnjo	15	5	-	-	HYPH
cord-329876-4cgrjnjo	15	6	CoV	CoV	NNP
cord-329876-4cgrjnjo	15	7	PL(pro	PL(pro	NNP
cord-329876-4cgrjnjo	15	8	)	)	-RRB-
cord-329876-4cgrjnjo	15	9	involves	involve	VBZ
cord-329876-4cgrjnjo	15	10	remarkable	remarkable	JJ
cord-329876-4cgrjnjo	15	11	differences	difference	NNS
cord-329876-4cgrjnjo	15	12	compared	compare	VBN
cord-329876-4cgrjnjo	15	13	to	to	IN
cord-329876-4cgrjnjo	15	14	the	the	DT
cord-329876-4cgrjnjo	15	15	corresponding	corresponding	JJ
cord-329876-4cgrjnjo	15	16	complex	complex	NN
cord-329876-4cgrjnjo	15	17	with	with	IN
cord-329876-4cgrjnjo	15	18	SARS	SARS	NNP
cord-329876-4cgrjnjo	15	19	-	-	HYPH
cord-329876-4cgrjnjo	15	20	CoV	CoV	NNP
cord-329876-4cgrjnjo	15	21	PL(pro	PL(pro	NNP
cord-329876-4cgrjnjo	15	22	)	)	-RRB-
cord-329876-4cgrjnjo	15	23	.	.	.
cord-329876-4cgrjnjo	16	1	The	the	DT
cord-329876-4cgrjnjo	16	2	structure	structure	NN
cord-329876-4cgrjnjo	16	3	and	and	CC
cord-329876-4cgrjnjo	16	4	the	the	DT
cord-329876-4cgrjnjo	16	5	mutational	mutational	JJ
cord-329876-4cgrjnjo	16	6	study	study	NN
cord-329876-4cgrjnjo	16	7	help	help	NN
cord-329876-4cgrjnjo	16	8	understand	understand	VB
cord-329876-4cgrjnjo	16	9	common	common	JJ
cord-329876-4cgrjnjo	16	10	and	and	CC
cord-329876-4cgrjnjo	16	11	unique	unique	JJ
cord-329876-4cgrjnjo	16	12	features	feature	NNS
cord-329876-4cgrjnjo	16	13	of	of	IN
cord-329876-4cgrjnjo	16	14	the	the	DT
cord-329876-4cgrjnjo	16	15	deubiquitinating	deubiquitinating	NN
cord-329876-4cgrjnjo	16	16	activity	activity	NN
cord-329876-4cgrjnjo	16	17	of	of	IN
cord-329876-4cgrjnjo	16	18	MERS	MERS	NNP
cord-329876-4cgrjnjo	16	19	-	-	HYPH
cord-329876-4cgrjnjo	16	20	CoV	CoV	NNP
cord-329876-4cgrjnjo	16	21	PL(pro	PL(pro	NNP
cord-329876-4cgrjnjo	16	22	)	)	-RRB-
cord-329876-4cgrjnjo	16	23	.	.	.
cord-329876-4cgrjnjo	17	1	ELECTRONIC	ELECTRONIC	NNP
cord-329876-4cgrjnjo	17	2	SUPPLEMENTARY	supplementary	JJ
cord-329876-4cgrjnjo	17	3	MATERIAL	material	NN
cord-329876-4cgrjnjo	17	4	:	:	:
cord-329876-4cgrjnjo	18	1	Supplementary	supplementary	JJ
cord-329876-4cgrjnjo	18	2	material	material	NN
cord-329876-4cgrjnjo	18	3	is	be	VBZ
cord-329876-4cgrjnjo	18	4	available	available	JJ
cord-329876-4cgrjnjo	18	5	for	for	IN
cord-329876-4cgrjnjo	18	6	this	this	DT
cord-329876-4cgrjnjo	18	7	article	article	NN
cord-329876-4cgrjnjo	18	8	at	at	IN
cord-329876-4cgrjnjo	18	9	10.1007	10.1007	CD
cord-329876-4cgrjnjo	18	10	/	/	SYM
cord-329876-4cgrjnjo	18	11	s12250	s12250	JJ
cord-329876-4cgrjnjo	18	12	-	-	HYPH
cord-329876-4cgrjnjo	18	13	016	016	CD
cord-329876-4cgrjnjo	18	14	-	-	HYPH
cord-329876-4cgrjnjo	18	15	3742	3742	CD
cord-329876-4cgrjnjo	18	16	-	-	SYM
cord-329876-4cgrjnjo	18	17	4	4	CD
cord-329876-4cgrjnjo	18	18	and	and	CC
cord-329876-4cgrjnjo	18	19	is	be	VBZ
cord-329876-4cgrjnjo	18	20	accessible	accessible	JJ
cord-329876-4cgrjnjo	18	21	for	for	IN
cord-329876-4cgrjnjo	18	22	authorized	authorize	VBN
cord-329876-4cgrjnjo	18	23	users	user	NNS
cord-329876-4cgrjnjo	18	24	.	.	.
cord-329876-4cgrjnjo	19	1	To	to	IN
cord-329876-4cgrjnjo	19	2	date	date	NN
cord-329876-4cgrjnjo	19	3	,	,	,
cord-329876-4cgrjnjo	19	4	six	six	CD
cord-329876-4cgrjnjo	19	5	coronaviruses	coronaviruse	NNS
cord-329876-4cgrjnjo	19	6	infecting	infect	VBG
cord-329876-4cgrjnjo	19	7	humans	human	NNS
cord-329876-4cgrjnjo	19	8	have	have	VBP
cord-329876-4cgrjnjo	19	9	been	be	VBN
cord-329876-4cgrjnjo	19	10	characterized	characterize	VBN
cord-329876-4cgrjnjo	19	11	.	.	.
cord-329876-4cgrjnjo	20	1	Infections	infection	NNS
cord-329876-4cgrjnjo	20	2	with	with	IN
cord-329876-4cgrjnjo	20	3	human	human	JJ
cord-329876-4cgrjnjo	20	4	coronaviruses	coronaviruse	NNS
cord-329876-4cgrjnjo	20	5	(	(	-LRB-
cord-329876-4cgrjnjo	20	6	HCoVs	HCoVs	NNP
cord-329876-4cgrjnjo	20	7	)	)	-RRB-
cord-329876-4cgrjnjo	20	8	229E	229e	CD
cord-329876-4cgrjnjo	21	1	(	(	-LRB-
cord-329876-4cgrjnjo	21	2	Hamre	Hamre	NNP
cord-329876-4cgrjnjo	21	3	&	&	CC
cord-329876-4cgrjnjo	21	4	Procknow	Procknow	NNP
cord-329876-4cgrjnjo	21	5	,	,	,
cord-329876-4cgrjnjo	21	6	1966	1966	CD
cord-329876-4cgrjnjo	21	7	)	)	-RRB-
cord-329876-4cgrjnjo	21	8	,	,	,
cord-329876-4cgrjnjo	21	9	OC43	OC43	NNP
cord-329876-4cgrjnjo	21	10	(	(	-LRB-
cord-329876-4cgrjnjo	21	11	McIntosh	McIntosh	NNP
cord-329876-4cgrjnjo	21	12	et	et	NNP
cord-329876-4cgrjnjo	21	13	al	al	NNP
cord-329876-4cgrjnjo	21	14	.	.	NNP
cord-329876-4cgrjnjo	21	15	,	,	,
cord-329876-4cgrjnjo	21	16	1967	1967	CD
cord-329876-4cgrjnjo	21	17	)	)	-RRB-
cord-329876-4cgrjnjo	21	18	,	,	.
cord-329876-4cgrjnjo	22	1	NL63	NL63	NNP
cord-329876-4cgrjnjo	23	1	(	(	-LRB-
cord-329876-4cgrjnjo	23	2	van	van	NNP
cord-329876-4cgrjnjo	23	3	der	der	NNP
cord-329876-4cgrjnjo	23	4	Hoek	Hoek	NNP
cord-329876-4cgrjnjo	23	5	et	et	NNP
cord-329876-4cgrjnjo	23	6	al	al	NNP
cord-329876-4cgrjnjo	23	7	.	.	NNP
cord-329876-4cgrjnjo	23	8	,	,	,
cord-329876-4cgrjnjo	23	9	2004	2004	CD
cord-329876-4cgrjnjo	23	10	)	)	-RRB-
cord-329876-4cgrjnjo	23	11	,	,	,
cord-329876-4cgrjnjo	23	12	and	and	CC
cord-329876-4cgrjnjo	23	13	HKU1	HKU1	NNP
cord-329876-4cgrjnjo	23	14	(	(	-LRB-
cord-329876-4cgrjnjo	23	15	Woo	woo	UH
cord-329876-4cgrjnjo	23	16	et	et	FW
cord-329876-4cgrjnjo	23	17	al	al	NNP
cord-329876-4cgrjnjo	23	18	.	.	NNP
cord-329876-4cgrjnjo	23	19	,	,	,
cord-329876-4cgrjnjo	23	20	2005	2005	CD
cord-329876-4cgrjnjo	23	21	)	)	-RRB-
cord-329876-4cgrjnjo	23	22	cause	cause	VB
cord-329876-4cgrjnjo	23	23	relatively	relatively	RB
cord-329876-4cgrjnjo	23	24	mild	mild	JJ
cord-329876-4cgrjnjo	23	25	symptoms	symptom	NNS
cord-329876-4cgrjnjo	23	26	in	in	IN
cord-329876-4cgrjnjo	23	27	most	most	JJS
cord-329876-4cgrjnjo	23	28	cases	case	NNS
cord-329876-4cgrjnjo	23	29	,	,	,
cord-329876-4cgrjnjo	23	30	whereas	whereas	IN
cord-329876-4cgrjnjo	23	31	severe	severe	JJ
cord-329876-4cgrjnjo	23	32	acute	acute	JJ
cord-329876-4cgrjnjo	23	33	res	res	FW
cord-329876-4cgrjnjo	23	34	-	-	HYPH
cord-329876-4cgrjnjo	23	35	piratory	piratory	JJ
cord-329876-4cgrjnjo	23	36	syndrome	syndrome	NN
cord-329876-4cgrjnjo	23	37	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	23	38	(	(	-LRB-
cord-329876-4cgrjnjo	23	39	SARS	SARS	NNP
cord-329876-4cgrjnjo	23	40	-	-	HYPH
cord-329876-4cgrjnjo	23	41	CoV	CoV	NNP
cord-329876-4cgrjnjo	23	42	;	;	:
cord-329876-4cgrjnjo	23	43	Ksiazek	Ksiazek	NNP
cord-329876-4cgrjnjo	23	44	et	et	NNP
cord-329876-4cgrjnjo	23	45	al	al	NNP
cord-329876-4cgrjnjo	23	46	.	.	NNP
cord-329876-4cgrjnjo	23	47	,	,	,
cord-329876-4cgrjnjo	23	48	2003	2003	CD
cord-329876-4cgrjnjo	23	49	;	;	:
cord-329876-4cgrjnjo	23	50	Kuiken	Kuiken	NNP
cord-329876-4cgrjnjo	23	51	et	et	FW
cord-329876-4cgrjnjo	23	52	al	al	NNP
cord-329876-4cgrjnjo	23	53	.	.	NNP
cord-329876-4cgrjnjo	23	54	,	,	,
cord-329876-4cgrjnjo	23	55	2003	2003	CD
cord-329876-4cgrjnjo	23	56	;	;	:
cord-329876-4cgrjnjo	23	57	Peiris	Peiris	NNP
cord-329876-4cgrjnjo	23	58	et	et	NNP
cord-329876-4cgrjnjo	23	59	al	al	NNP
cord-329876-4cgrjnjo	23	60	.	.	NNP
cord-329876-4cgrjnjo	23	61	,	,	,
cord-329876-4cgrjnjo	23	62	2003	2003	CD
cord-329876-4cgrjnjo	23	63	)	)	-RRB-
cord-329876-4cgrjnjo	23	64	and	and	CC
cord-329876-4cgrjnjo	23	65	Middle	Middle	NNP
cord-329876-4cgrjnjo	23	66	-	-	HYPH
cord-329876-4cgrjnjo	23	67	East	East	NNP
cord-329876-4cgrjnjo	23	68	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	23	69	syndrome	syndrome	NN
cord-329876-4cgrjnjo	23	70	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	23	71	(	(	-LRB-
cord-329876-4cgrjnjo	23	72	MERS	MERS	NNP
cord-329876-4cgrjnjo	23	73	-	-	HYPH
cord-329876-4cgrjnjo	23	74	CoV	CoV	NNP
cord-329876-4cgrjnjo	23	75	;	;	:
cord-329876-4cgrjnjo	24	1	Zaki	Zaki	NNP
cord-329876-4cgrjnjo	24	2	et	et	NNP
cord-329876-4cgrjnjo	24	3	al	al	NNP
cord-329876-4cgrjnjo	24	4	.	.	NNP
cord-329876-4cgrjnjo	24	5	,	,	,
cord-329876-4cgrjnjo	24	6	2012	2012	CD
cord-329876-4cgrjnjo	24	7	)	)	-RRB-
cord-329876-4cgrjnjo	24	8	are	be	VBP
cord-329876-4cgrjnjo	24	9	connected	connect	VBN
cord-329876-4cgrjnjo	24	10	with	with	IN
cord-329876-4cgrjnjo	24	11	severe	severe	JJ
cord-329876-4cgrjnjo	24	12	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	24	13	-	-	HYPH
cord-329876-4cgrjnjo	24	14	tract	tract	NN
cord-329876-4cgrjnjo	24	15	infection	infection	NN
cord-329876-4cgrjnjo	24	16	and	and	CC
cord-329876-4cgrjnjo	24	17	,	,	,
cord-329876-4cgrjnjo	24	18	in	in	IN
cord-329876-4cgrjnjo	24	19	particular	particular	JJ
cord-329876-4cgrjnjo	24	20	in	in	IN
cord-329876-4cgrjnjo	24	21	case	case	NN
cord-329876-4cgrjnjo	24	22	of	of	IN
cord-329876-4cgrjnjo	24	23	MERS	MERS	NNP
cord-329876-4cgrjnjo	24	24	-	-	HYPH
cord-329876-4cgrjnjo	24	25	CoV	CoV	NNP
cord-329876-4cgrjnjo	24	26	,	,	,
cord-329876-4cgrjnjo	24	27	acute	acute	JJ
cord-329876-4cgrjnjo	24	28	renal	renal	JJ
cord-329876-4cgrjnjo	24	29	failure	failure	NN
cord-329876-4cgrjnjo	24	30	(	(	-LRB-
cord-329876-4cgrjnjo	24	31	Eckerle	Eckerle	NNP
cord-329876-4cgrjnjo	24	32	et	et	NNP
cord-329876-4cgrjnjo	24	33	al	al	NNP
cord-329876-4cgrjnjo	24	34	.	.	NNP
cord-329876-4cgrjnjo	24	35	,	,	,
cord-329876-4cgrjnjo	24	36	2013	2013	CD
cord-329876-4cgrjnjo	24	37	)	)	-RRB-
cord-329876-4cgrjnjo	24	38	,	,	,
cord-329876-4cgrjnjo	24	39	leading	lead	VBG
cord-329876-4cgrjnjo	24	40	to	to	IN
cord-329876-4cgrjnjo	24	41	high	high	JJ
cord-329876-4cgrjnjo	24	42	case	case	NN
cord-329876-4cgrjnjo	24	43	-	-	HYPH
cord-329876-4cgrjnjo	24	44	fatality	fatality	NN
cord-329876-4cgrjnjo	24	45	rates	rate	NNS
cord-329876-4cgrjnjo	24	46	of	of	IN
cord-329876-4cgrjnjo	24	47	~10	~10	CD
cord-329876-4cgrjnjo	24	48	and	and	CC
cord-329876-4cgrjnjo	24	49	35	35	CD
cord-329876-4cgrjnjo	24	50	%	%	NN
cord-329876-4cgrjnjo	24	51	,	,	,
cord-329876-4cgrjnjo	24	52	respectively	respectively	RB
cord-329876-4cgrjnjo	24	53	.	.	.
cord-329876-4cgrjnjo	25	1	In	in	IN
cord-329876-4cgrjnjo	25	2	spite	spite	NN
cord-329876-4cgrjnjo	25	3	of	of	IN
cord-329876-4cgrjnjo	25	4	13	13	CD
cord-329876-4cgrjnjo	25	5	years	year	NNS
cord-329876-4cgrjnjo	25	6	of	of	IN
cord-329876-4cgrjnjo	25	7	research	research	NN
cord-329876-4cgrjnjo	25	8	on	on	IN
cord-329876-4cgrjnjo	25	9	SARS	SARS	NNP
cord-329876-4cgrjnjo	25	10	-	-	HYPH
cord-329876-4cgrjnjo	25	11	CoV	CoV	NNP
cord-329876-4cgrjnjo	25	12	(	(	-LRB-
cord-329876-4cgrjnjo	25	13	Hilgenfeld	Hilgenfeld	NNP
cord-329876-4cgrjnjo	25	14	&	&	CC
cord-329876-4cgrjnjo	25	15	Peiris	Peiris	NNP
cord-329876-4cgrjnjo	25	16	,	,	,
cord-329876-4cgrjnjo	25	17	2013	2013	CD
cord-329876-4cgrjnjo	25	18	)	)	-RRB-
cord-329876-4cgrjnjo	25	19	,	,	,
cord-329876-4cgrjnjo	25	20	no	no	DT
cord-329876-4cgrjnjo	25	21	approved	approve	VBN
cord-329876-4cgrjnjo	25	22	drugs	drug	NNS
cord-329876-4cgrjnjo	25	23	or	or	CC
cord-329876-4cgrjnjo	25	24	vaccines	vaccine	NNS
cord-329876-4cgrjnjo	25	25	are	be	VBP
cord-329876-4cgrjnjo	25	26	available	available	JJ
cord-329876-4cgrjnjo	25	27	for	for	IN
cord-329876-4cgrjnjo	25	28	the	the	DT
cord-329876-4cgrjnjo	25	29	treatment	treatment	NN
cord-329876-4cgrjnjo	25	30	or	or	CC
cord-329876-4cgrjnjo	25	31	prevention	prevention	NN
cord-329876-4cgrjnjo	25	32	of	of	IN
cord-329876-4cgrjnjo	25	33	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	25	34	infection	infection	NN
cord-329876-4cgrjnjo	26	1	(	(	-LRB-
cord-329876-4cgrjnjo	26	2	Wang	Wang	NNP
cord-329876-4cgrjnjo	26	3	et	et	NNP
cord-329876-4cgrjnjo	26	4	al	al	NNP
cord-329876-4cgrjnjo	26	5	.	.	NNP
cord-329876-4cgrjnjo	26	6	,	,	,
cord-329876-4cgrjnjo	26	7	2016	2016	CD
cord-329876-4cgrjnjo	26	8	)	)	-RRB-
cord-329876-4cgrjnjo	26	9	.	.	.
cord-329876-4cgrjnjo	27	1	This	this	DT
cord-329876-4cgrjnjo	27	2	is	be	VBZ
cord-329876-4cgrjnjo	27	3	mainly	mainly	RB
cord-329876-4cgrjnjo	27	4	due	due	JJ
cord-329876-4cgrjnjo	27	5	to	to	IN
cord-329876-4cgrjnjo	27	6	the	the	DT
cord-329876-4cgrjnjo	27	7	fact	fact	NN
cord-329876-4cgrjnjo	27	8	that	that	IN
cord-329876-4cgrjnjo	27	9	although	although	IN
cord-329876-4cgrjnjo	27	10	these	these	DT
cord-329876-4cgrjnjo	27	11	emerging	emerge	VBG
cord-329876-4cgrjnjo	27	12	viruses	virus	NNS
cord-329876-4cgrjnjo	27	13	have	have	VBP
cord-329876-4cgrjnjo	27	14	devastating	devastating	JJ
cord-329876-4cgrjnjo	27	15	effects	effect	NNS
cord-329876-4cgrjnjo	27	16	on	on	IN
cord-329876-4cgrjnjo	27	17	those	those	DT
cord-329876-4cgrjnjo	27	18	infected	infect	VBN
cord-329876-4cgrjnjo	27	19	,	,	,
cord-329876-4cgrjnjo	27	20	the	the	DT
cord-329876-4cgrjnjo	27	21	absolute	absolute	JJ
cord-329876-4cgrjnjo	27	22	numbers	number	NNS
cord-329876-4cgrjnjo	27	23	of	of	IN
cord-329876-4cgrjnjo	27	24	cases	case	NNS
cord-329876-4cgrjnjo	27	25	(	(	-LRB-
cord-329876-4cgrjnjo	27	26	~8000	~8000	NFP
cord-329876-4cgrjnjo	27	27	for	for	IN
cord-329876-4cgrjnjo	27	28	SARS	SARS	NNP
cord-329876-4cgrjnjo	27	29	,	,	,
cord-329876-4cgrjnjo	27	30	1733	1733	CD
cord-329876-4cgrjnjo	27	31	so	so	RB
cord-329876-4cgrjnjo	27	32	far	far	RB
cord-329876-4cgrjnjo	27	33	for	for	IN
cord-329876-4cgrjnjo	27	34	MERS	MERS	NNPS
cord-329876-4cgrjnjo	27	35	;	;	:
cord-329876-4cgrjnjo	27	36	(	(	-LRB-
cord-329876-4cgrjnjo	27	37	http://www.who.int	http://www.who.int	ADD
cord-329876-4cgrjnjo	27	38	)	)	-RRB-
cord-329876-4cgrjnjo	27	39	)	)	-RRB-
cord-329876-4cgrjnjo	27	40	imply	imply	VBP
cord-329876-4cgrjnjo	27	41	that	that	IN
cord-329876-4cgrjnjo	27	42	the	the	DT
cord-329876-4cgrjnjo	27	43	de	de	NN
cord-329876-4cgrjnjo	27	44	-	-	NN
cord-329876-4cgrjnjo	27	45	velopment	velopment	NN
cord-329876-4cgrjnjo	27	46	of	of	IN
cord-329876-4cgrjnjo	27	47	specific	specific	JJ
cord-329876-4cgrjnjo	27	48	antivirals	antiviral	NNS
cord-329876-4cgrjnjo	27	49	is	be	VBZ
cord-329876-4cgrjnjo	27	50	very	very	RB
cord-329876-4cgrjnjo	27	51	likely	likely	JJ
cord-329876-4cgrjnjo	27	52	not	not	RB
cord-329876-4cgrjnjo	27	53	commercially	commercially	RB
cord-329876-4cgrjnjo	27	54	viable	viable	JJ
cord-329876-4cgrjnjo	27	55	.	.	.
cord-329876-4cgrjnjo	28	1	On	on	IN
cord-329876-4cgrjnjo	28	2	the	the	DT
cord-329876-4cgrjnjo	28	3	other	other	JJ
cord-329876-4cgrjnjo	28	4	hand	hand	NN
cord-329876-4cgrjnjo	28	5	,	,	,
cord-329876-4cgrjnjo	28	6	the	the	DT
cord-329876-4cgrjnjo	28	7	global	global	JJ
cord-329876-4cgrjnjo	28	8	risk	risk	NN
cord-329876-4cgrjnjo	28	9	posed	pose	VBN
cord-329876-4cgrjnjo	28	10	by	by	IN
cord-329876-4cgrjnjo	28	11	MERS	MERS	NNP
cord-329876-4cgrjnjo	28	12	-	-	HYPH
cord-329876-4cgrjnjo	28	13	CoV	CoV	NNP
cord-329876-4cgrjnjo	28	14	must	must	MD
cord-329876-4cgrjnjo	28	15	not	not	RB
cord-329876-4cgrjnjo	28	16	be	be	VB
cord-329876-4cgrjnjo	28	17	underestimated	underestimate	VBN
cord-329876-4cgrjnjo	28	18	.	.	.
cord-329876-4cgrjnjo	29	1	Since	since	IN
cord-329876-4cgrjnjo	29	2	its	-PRON-	PRP$
cord-329876-4cgrjnjo	29	3	discovery	discovery	NN
cord-329876-4cgrjnjo	29	4	in	in	IN
cord-329876-4cgrjnjo	29	5	September	September	NNP
cord-329876-4cgrjnjo	29	6	2012	2012	CD
cord-329876-4cgrjnjo	29	7	,	,	,
cord-329876-4cgrjnjo	29	8	the	the	DT
cord-329876-4cgrjnjo	29	9	number	number	NN
cord-329876-4cgrjnjo	29	10	of	of	IN
cord-329876-4cgrjnjo	29	11	MERS	MERS	NNP
cord-329876-4cgrjnjo	29	12	cases	case	NNS
cord-329876-4cgrjnjo	29	13	reported	report	VBN
cord-329876-4cgrjnjo	29	14	has	have	VBZ
cord-329876-4cgrjnjo	29	15	been	be	VBN
cord-329876-4cgrjnjo	29	16	rising	rise	VBG
cord-329876-4cgrjnjo	29	17	steadily	steadily	RB
cord-329876-4cgrjnjo	29	18	,	,	,
cord-329876-4cgrjnjo	29	19	with	with	IN
cord-329876-4cgrjnjo	29	20	some	some	DT
cord-329876-4cgrjnjo	29	21	intermittent	intermittent	JJ
cord-329876-4cgrjnjo	29	22	peaks	peak	NNS
cord-329876-4cgrjnjo	29	23	connected	connect	VBN
cord-329876-4cgrjnjo	29	24	to	to	IN
cord-329876-4cgrjnjo	29	25	hospital	hospital	NN
cord-329876-4cgrjnjo	29	26	outbreaks	outbreak	NNS
cord-329876-4cgrjnjo	29	27	in	in	IN
cord-329876-4cgrjnjo	29	28	Saudi	Saudi	NNP
cord-329876-4cgrjnjo	29	29	Arabia	Arabia	NNP
cord-329876-4cgrjnjo	30	1	(	(	-LRB-
cord-329876-4cgrjnjo	30	2	Assiri	Assiri	NNP
cord-329876-4cgrjnjo	30	3	et	et	NNP
cord-329876-4cgrjnjo	30	4	al	al	NNP
cord-329876-4cgrjnjo	30	5	.	.	NNP
cord-329876-4cgrjnjo	30	6	,	,	,
cord-329876-4cgrjnjo	30	7	2013	2013	CD
cord-329876-4cgrjnjo	30	8	)	)	-RRB-
cord-329876-4cgrjnjo	30	9	.	.	.
cord-329876-4cgrjnjo	31	1	Man	man	NN
cord-329876-4cgrjnjo	31	2	-	-	HYPH
cord-329876-4cgrjnjo	31	3	to	to	IN
cord-329876-4cgrjnjo	31	4	-	-	HYPH
cord-329876-4cgrjnjo	31	5	man	man	NN
cord-329876-4cgrjnjo	31	6	transmission	transmission	NN
cord-329876-4cgrjnjo	31	7	of	of	IN
cord-329876-4cgrjnjo	31	8	MERS	MERS	NNP
cord-329876-4cgrjnjo	31	9	-	-	HYPH
cord-329876-4cgrjnjo	31	10	CoV	CoV	NNP
cord-329876-4cgrjnjo	31	11	has	have	VBZ
cord-329876-4cgrjnjo	31	12	also	also	RB
cord-329876-4cgrjnjo	31	13	been	be	VBN
cord-329876-4cgrjnjo	31	14	impressively	impressively	RB
cord-329876-4cgrjnjo	31	15	demonstrated	demonstrate	VBN
cord-329876-4cgrjnjo	31	16	by	by	IN
cord-329876-4cgrjnjo	31	17	the	the	DT
cord-329876-4cgrjnjo	31	18	recent	recent	JJ
cord-329876-4cgrjnjo	31	19	outbreak	outbreak	NN
cord-329876-4cgrjnjo	31	20	of	of	IN
cord-329876-4cgrjnjo	31	21	MERS	MERS	NNP
cord-329876-4cgrjnjo	31	22	in	in	IN
cord-329876-4cgrjnjo	31	23	South	South	NNP
cord-329876-4cgrjnjo	31	24	Korea	Korea	NNP
cord-329876-4cgrjnjo	31	25	,	,	,
cord-329876-4cgrjnjo	31	26	which	which	WDT
cord-329876-4cgrjnjo	31	27	was	be	VBD
cord-329876-4cgrjnjo	31	28	traced	trace	VBN
cord-329876-4cgrjnjo	31	29	back	back	RB
cord-329876-4cgrjnjo	31	30	to	to	IN
cord-329876-4cgrjnjo	31	31	a	a	DT
cord-329876-4cgrjnjo	31	32	single	single	JJ
cord-329876-4cgrjnjo	31	33	traveller	traveller	NN
cord-329876-4cgrjnjo	31	34	from	from	IN
cord-329876-4cgrjnjo	31	35	the	the	DT
cord-329876-4cgrjnjo	31	36	Arab	arab	JJ
cord-329876-4cgrjnjo	31	37	peninsula	peninsula	NN
cord-329876-4cgrjnjo	31	38	(	(	-LRB-
cord-329876-4cgrjnjo	31	39	Butler	Butler	NNP
cord-329876-4cgrjnjo	31	40	,	,	,
cord-329876-4cgrjnjo	31	41	2015	2015	CD
cord-329876-4cgrjnjo	31	42	)	)	-RRB-
cord-329876-4cgrjnjo	31	43	.	.	.
cord-329876-4cgrjnjo	32	1	Therefore	therefore	RB
cord-329876-4cgrjnjo	32	2	,	,	,
cord-329876-4cgrjnjo	32	3	it	-PRON-	PRP
cord-329876-4cgrjnjo	32	4	is	be	VBZ
cord-329876-4cgrjnjo	32	5	imperative	imperative	JJ
cord-329876-4cgrjnjo	32	6	that	that	IN
cord-329876-4cgrjnjo	32	7	academic	academic	JJ
cord-329876-4cgrjnjo	32	8	laboratories	laboratory	NNS
cord-329876-4cgrjnjo	32	9	help	help	VBP
cord-329876-4cgrjnjo	32	10	increase	increase	VB
cord-329876-4cgrjnjo	32	11	the	the	DT
cord-329876-4cgrjnjo	32	12	preparedness	preparedness	NN
cord-329876-4cgrjnjo	32	13	against	against	IN
cord-329876-4cgrjnjo	32	14	a	a	DT
cord-329876-4cgrjnjo	32	15	possible	possible	JJ
cord-329876-4cgrjnjo	32	16	MERS	MERS	NNP
cord-329876-4cgrjnjo	32	17	-	-	HYPH
cord-329876-4cgrjnjo	32	18	CoV	cov	NN
cord-329876-4cgrjnjo	32	19	pandemic	pandemic	NN
cord-329876-4cgrjnjo	32	20	by	by	IN
cord-329876-4cgrjnjo	32	21	characterizing	characterize	VBG
cord-329876-4cgrjnjo	32	22	antiviral	antiviral	JJ
cord-329876-4cgrjnjo	32	23	drug	drug	NN
cord-329876-4cgrjnjo	32	24	targets	target	NNS
cord-329876-4cgrjnjo	32	25	and	and	CC
cord-329876-4cgrjnjo	32	26	by	by	IN
cord-329876-4cgrjnjo	32	27	identifying	identify	VBG
cord-329876-4cgrjnjo	32	28	lead	lead	JJ
cord-329876-4cgrjnjo	32	29	compounds	compound	NNS
cord-329876-4cgrjnjo	32	30	interfering	interfere	VBG
cord-329876-4cgrjnjo	32	31	with	with	IN
cord-329876-4cgrjnjo	32	32	them	-PRON-	PRP
cord-329876-4cgrjnjo	32	33	.	.	.
cord-329876-4cgrjnjo	33	1	In	in	IN
cord-329876-4cgrjnjo	33	2	order	order	NN
cord-329876-4cgrjnjo	33	3	to	to	TO
cord-329876-4cgrjnjo	33	4	successfully	successfully	RB
cord-329876-4cgrjnjo	33	5	infect	infect	VB
cord-329876-4cgrjnjo	33	6	humans	human	NNS
cord-329876-4cgrjnjo	33	7	,	,	,
cord-329876-4cgrjnjo	33	8	a	a	DT
cord-329876-4cgrjnjo	33	9	virus	virus	NN
cord-329876-4cgrjnjo	33	10	has	have	VBZ
cord-329876-4cgrjnjo	33	11	to	to	TO
cord-329876-4cgrjnjo	33	12	meet	meet	VB
cord-329876-4cgrjnjo	33	13	at	at	RB
cord-329876-4cgrjnjo	33	14	least	least	RBS
cord-329876-4cgrjnjo	33	15	two	two	CD
cord-329876-4cgrjnjo	33	16	conditions	condition	NNS
cord-329876-4cgrjnjo	33	17	:	:	:
cord-329876-4cgrjnjo	33	18	1	1	LS
cord-329876-4cgrjnjo	33	19	)	)	-RRB-
cord-329876-4cgrjnjo	33	20	,	,	,
cord-329876-4cgrjnjo	33	21	it	-PRON-	PRP
cord-329876-4cgrjnjo	33	22	should	should	MD
cord-329876-4cgrjnjo	33	23	maintain	maintain	VB
cord-329876-4cgrjnjo	33	24	a	a	DT
cord-329876-4cgrjnjo	33	25	sufficiently	sufficiently	RB
cord-329876-4cgrjnjo	33	26	correct	correct	JJ
cord-329876-4cgrjnjo	33	27	replication	replication	NN
cord-329876-4cgrjnjo	33	28	of	of	IN
cord-329876-4cgrjnjo	33	29	its	-PRON-	PRP$
cord-329876-4cgrjnjo	33	30	genetic	genetic	JJ
cord-329876-4cgrjnjo	33	31	material	material	NN
cord-329876-4cgrjnjo	33	32	;	;	:
cord-329876-4cgrjnjo	33	33	2	2	CD
cord-329876-4cgrjnjo	33	34	)	)	-RRB-
cord-329876-4cgrjnjo	33	35	,	,	,
cord-329876-4cgrjnjo	33	36	it	-PRON-	PRP
cord-329876-4cgrjnjo	33	37	should	should	MD
cord-329876-4cgrjnjo	33	38	inhibit	inhibit	VB
cord-329876-4cgrjnjo	33	39	the	the	DT
cord-329876-4cgrjnjo	33	40	host	host	NN
cord-329876-4cgrjnjo	33	41	antiviral	antiviral	JJ
cord-329876-4cgrjnjo	33	42	response	response	NN
cord-329876-4cgrjnjo	33	43	.	.	.
cord-329876-4cgrjnjo	34	1	The	the	DT
cord-329876-4cgrjnjo	34	2	papainlike	papainlike	JJ
cord-329876-4cgrjnjo	34	3	protease	protease	NN
cord-329876-4cgrjnjo	34	4	(	(	-LRB-
cord-329876-4cgrjnjo	34	5	PL	pl	NN
cord-329876-4cgrjnjo	34	6	pro	pro	FW
cord-329876-4cgrjnjo	34	7	)	)	-RRB-
cord-329876-4cgrjnjo	34	8	of	of	IN
cord-329876-4cgrjnjo	34	9	MERS	MERS	NNP
cord-329876-4cgrjnjo	34	10	-	-	HYPH
cord-329876-4cgrjnjo	34	11	CoV	CoV	NNP
cord-329876-4cgrjnjo	34	12	(	(	-LRB-
cord-329876-4cgrjnjo	34	13	or	or	CC
cord-329876-4cgrjnjo	34	14	SARS	SARS	NNP
cord-329876-4cgrjnjo	34	15	-	-	HYPH
cord-329876-4cgrjnjo	34	16	CoV	CoV	NNP
cord-329876-4cgrjnjo	34	17	)	)	-RRB-
cord-329876-4cgrjnjo	34	18	is	be	VBZ
cord-329876-4cgrjnjo	34	19	involved	involve	VBN
cord-329876-4cgrjnjo	34	20	in	in	IN
cord-329876-4cgrjnjo	34	21	both	both	DT
cord-329876-4cgrjnjo	34	22	of	of	IN
cord-329876-4cgrjnjo	34	23	these	these	DT
cord-329876-4cgrjnjo	34	24	tasks	task	NNS
cord-329876-4cgrjnjo	34	25	(	(	-LRB-
cord-329876-4cgrjnjo	35	1	Yang	Yang	NNP
cord-329876-4cgrjnjo	35	2	et	et	NNP
cord-329876-4cgrjnjo	35	3	al	al	NNP
cord-329876-4cgrjnjo	35	4	.	.	NNP
cord-329876-4cgrjnjo	35	5	,	,	,
cord-329876-4cgrjnjo	35	6	2013	2013	CD
cord-329876-4cgrjnjo	35	7	;	;	:
cord-329876-4cgrjnjo	35	8	Barretto	Barretto	NNP
cord-329876-4cgrjnjo	35	9	et	et	NNP
cord-329876-4cgrjnjo	35	10	al	al	NNP
cord-329876-4cgrjnjo	35	11	,	,	,
cord-329876-4cgrjnjo	35	12	2005	2005	CD
cord-329876-4cgrjnjo	35	13	)	)	-RRB-
cord-329876-4cgrjnjo	35	14	.	.	.
cord-329876-4cgrjnjo	36	1	The	the	DT
cord-329876-4cgrjnjo	36	2	PL	PL	NNP
cord-329876-4cgrjnjo	36	3	pro	pro	NN
cord-329876-4cgrjnjo	36	4	is	be	VBZ
cord-329876-4cgrjnjo	36	5	a	a	DT
cord-329876-4cgrjnjo	36	6	domain	domain	NN
cord-329876-4cgrjnjo	36	7	located	locate	VBN
cord-329876-4cgrjnjo	36	8	in	in	IN
cord-329876-4cgrjnjo	36	9	the	the	DT
cord-329876-4cgrjnjo	36	10	middle	middle	JJ
cord-329876-4cgrjnjo	36	11	part	part	NN
cord-329876-4cgrjnjo	36	12	of	of	IN
cord-329876-4cgrjnjo	36	13	the	the	DT
cord-329876-4cgrjnjo	36	14	largest	large	JJS
cord-329876-4cgrjnjo	36	15	non	non	JJ
cord-329876-4cgrjnjo	36	16	-	-	JJ
cord-329876-4cgrjnjo	36	17	structural	structural	JJ
cord-329876-4cgrjnjo	36	18	protein	protein	NN
cord-329876-4cgrjnjo	36	19	,	,	,
cord-329876-4cgrjnjo	36	20	Nsp3	Nsp3	NNP
cord-329876-4cgrjnjo	36	21	,	,	,
cord-329876-4cgrjnjo	36	22	of	of	IN
cord-329876-4cgrjnjo	36	23	MERS	MERS	NNP
cord-329876-4cgrjnjo	36	24	-	-	HYPH
cord-329876-4cgrjnjo	36	25	CoV	CoV	NNP
cord-329876-4cgrjnjo	36	26	(	(	-LRB-
cord-329876-4cgrjnjo	36	27	or	or	CC
cord-329876-4cgrjnjo	36	28	SARS	SARS	NNP
cord-329876-4cgrjnjo	36	29	-	-	HYPH
cord-329876-4cgrjnjo	36	30	CoV	CoV	NNP
cord-329876-4cgrjnjo	36	31	)	)	-RRB-
cord-329876-4cgrjnjo	36	32	.	.	.
cord-329876-4cgrjnjo	37	1	It	-PRON-	PRP
cord-329876-4cgrjnjo	37	2	is	be	VBZ
cord-329876-4cgrjnjo	37	3	responsible	responsible	JJ
cord-329876-4cgrjnjo	37	4	for	for	IN
cord-329876-4cgrjnjo	37	5	releasing	release	VBG
cord-329876-4cgrjnjo	37	6	Nsp1	Nsp1	NNP
cord-329876-4cgrjnjo	37	7	,	,	,
cord-329876-4cgrjnjo	37	8	Nsp2	Nsp2	NNP
cord-329876-4cgrjnjo	37	9	,	,	,
cord-329876-4cgrjnjo	37	10	and	and	CC
cord-329876-4cgrjnjo	37	11	Nsp3	Nsp3	NNS
cord-329876-4cgrjnjo	37	12	from	from	IN
cord-329876-4cgrjnjo	37	13	the	the	DT
cord-329876-4cgrjnjo	37	14	polyproteins	polyprotein	NNS
cord-329876-4cgrjnjo	37	15	1a	1a	CD
cord-329876-4cgrjnjo	38	1	(	(	-LRB-
cord-329876-4cgrjnjo	38	2	pp1a	pp1a	NNP
cord-329876-4cgrjnjo	38	3	)	)	-RRB-
cord-329876-4cgrjnjo	38	4	and	and	CC
cord-329876-4cgrjnjo	38	5	1ab	1ab	JJ
cord-329876-4cgrjnjo	38	6	(	(	-LRB-
cord-329876-4cgrjnjo	38	7	pp1ab	pp1ab	NNP
cord-329876-4cgrjnjo	38	8	)	)	-RRB-
cord-329876-4cgrjnjo	38	9	,	,	,
cord-329876-4cgrjnjo	38	10	an	an	DT
cord-329876-4cgrjnjo	38	11	essential	essential	JJ
cord-329876-4cgrjnjo	38	12	step	step	NN
cord-329876-4cgrjnjo	38	13	of	of	IN
cord-329876-4cgrjnjo	38	14	replication	replication	NN
cord-329876-4cgrjnjo	38	15	(	(	-LRB-
cord-329876-4cgrjnjo	38	16	Harcourt	Harcourt	NNP
cord-329876-4cgrjnjo	38	17	et	et	NNP
cord-329876-4cgrjnjo	38	18	al	al	NNP
cord-329876-4cgrjnjo	38	19	.	.	NNP
cord-329876-4cgrjnjo	38	20	,	,	,
cord-329876-4cgrjnjo	38	21	2004	2004	CD
cord-329876-4cgrjnjo	38	22	)	)	-RRB-
cord-329876-4cgrjnjo	38	23	.	.	.
cord-329876-4cgrjnjo	39	1	Like	like	IN
cord-329876-4cgrjnjo	39	2	its	-PRON-	PRP$
cord-329876-4cgrjnjo	39	3	SARS	SARS	NNP
cord-329876-4cgrjnjo	39	4	-	-	HYPH
cord-329876-4cgrjnjo	39	5	CoV	CoV	NNP
cord-329876-4cgrjnjo	39	6	counterpart	counterpart	NN
cord-329876-4cgrjnjo	39	7	,	,	,
cord-329876-4cgrjnjo	39	8	the	the	DT
cord-329876-4cgrjnjo	39	9	MERS	MERS	NNP
cord-329876-4cgrjnjo	39	10	-	-	HYPH
cord-329876-4cgrjnjo	39	11	CoV	CoV	NNP
cord-329876-4cgrjnjo	39	12	PL	pl	NN
cord-329876-4cgrjnjo	39	13	pro	pro	NNP
cord-329876-4cgrjnjo	39	14	also	also	RB
cord-329876-4cgrjnjo	39	15	has	have	VBZ
cord-329876-4cgrjnjo	39	16	deubiquitinating	deubiquitinate	VBG
cord-329876-4cgrjnjo	39	17	(	(	-LRB-
cord-329876-4cgrjnjo	39	18	DUB	dub	NN
cord-329876-4cgrjnjo	39	19	)	)	-RRB-
cord-329876-4cgrjnjo	39	20	and	and	CC
cord-329876-4cgrjnjo	39	21	deISGylating	deisgylate	VBG
cord-329876-4cgrjnjo	39	22	activities	activity	NNS
cord-329876-4cgrjnjo	39	23	in	in	IN
cord-329876-4cgrjnjo	39	24	vivo	vivo	NN
cord-329876-4cgrjnjo	39	25	as	as	RB
cord-329876-4cgrjnjo	39	26	well	well	RB
cord-329876-4cgrjnjo	39	27	as	as	IN
cord-329876-4cgrjnjo	39	28	in	in	IN
cord-329876-4cgrjnjo	39	29	vitro	vitro	FW
cord-329876-4cgrjnjo	40	1	(	(	-LRB-
cord-329876-4cgrjnjo	40	2	Yang	Yang	NNP
cord-329876-4cgrjnjo	40	3	et	et	NNP
cord-329876-4cgrjnjo	40	4	al	al	NNP
cord-329876-4cgrjnjo	40	5	.	.	NNP
cord-329876-4cgrjnjo	40	6	,	,	,
cord-329876-4cgrjnjo	40	7	2013	2013	CD
cord-329876-4cgrjnjo	40	8	;	;	:
cord-329876-4cgrjnjo	40	9	Mielech	Mielech	NNP
cord-329876-4cgrjnjo	40	10	et	et	NNP
cord-329876-4cgrjnjo	40	11	al	al	NNP
cord-329876-4cgrjnjo	40	12	.	.	NNP
cord-329876-4cgrjnjo	40	13	,	,	,
cord-329876-4cgrjnjo	40	14	2014	2014	CD
cord-329876-4cgrjnjo	40	15	;	;	:
cord-329876-4cgrjnjo	40	16	Lei	Lei	NNP
cord-329876-4cgrjnjo	40	17	et	et	FW
cord-329876-4cgrjnjo	40	18	al	al	NNP
cord-329876-4cgrjnjo	40	19	.	.	NNP
cord-329876-4cgrjnjo	40	20	,	,	,
cord-329876-4cgrjnjo	40	21	2014	2014	CD
cord-329876-4cgrjnjo	40	22	;	;	.
cord-329876-4cgrjnjo	41	1	Baez	Baez	NNP
cord-329876-4cgrjnjo	41	2	-	-	HYPH
cord-329876-4cgrjnjo	41	3	Santos	Santos	NNP
cord-329876-4cgrjnjo	41	4	et	et	FW
cord-329876-4cgrjnjo	41	5	al	al	NNP
cord-329876-4cgrjnjo	41	6	.	.	.
cord-329876-4cgrjnjo	42	1	,	,	,
cord-329876-4cgrjnjo	42	2	2014b	2014b	CD
cord-329876-4cgrjnjo	42	3	)	)	-RRB-
cord-329876-4cgrjnjo	42	4	.	.	.
cord-329876-4cgrjnjo	43	1	K48-and	K48-and	NNP
cord-329876-4cgrjnjo	44	1	K63-polyubiquitin	K63-polyubiquitin	NNP
cord-329876-4cgrjnjo	44	2	poly	poly	NNP
cord-329876-4cgrjnjo	44	3	(	(	-LRB-
cord-329876-4cgrjnjo	44	4	Ub	Ub	NNP
cord-329876-4cgrjnjo	44	5	)	)	-RRB-
cord-329876-4cgrjnjo	44	6	and	and	CC
cord-329876-4cgrjnjo	44	7	ISG15	isg15	NN
cord-329876-4cgrjnjo	45	1	(	(	-LRB-
cord-329876-4cgrjnjo	45	2	interferon	interferon	NN
cord-329876-4cgrjnjo	45	3	-	-	HYPH
cord-329876-4cgrjnjo	45	4	stimulated	stimulate	VBN
cord-329876-4cgrjnjo	45	5	gene	gene	NN
cord-329876-4cgrjnjo	45	6	15)conjugated	15)conjugated	CD
cord-329876-4cgrjnjo	45	7	targets	target	NNS
cord-329876-4cgrjnjo	45	8	are	be	VBP
cord-329876-4cgrjnjo	45	9	usually	usually	RB
cord-329876-4cgrjnjo	45	10	involved	involve	VBN
cord-329876-4cgrjnjo	45	11	in	in	IN
cord-329876-4cgrjnjo	45	12	host	host	NN
cord-329876-4cgrjnjo	45	13	innate	innate	JJ
cord-329876-4cgrjnjo	45	14	immune	immune	JJ
cord-329876-4cgrjnjo	45	15	regulation	regulation	NN
cord-329876-4cgrjnjo	46	1	(	(	-LRB-
cord-329876-4cgrjnjo	46	2	Liu	Liu	NNP
cord-329876-4cgrjnjo	46	3	et	et	NNP
cord-329876-4cgrjnjo	46	4	al	al	NNP
cord-329876-4cgrjnjo	46	5	.	.	NNP
cord-329876-4cgrjnjo	46	6	,	,	,
cord-329876-4cgrjnjo	46	7	2005	2005	CD
cord-329876-4cgrjnjo	46	8	;	;	:
cord-329876-4cgrjnjo	47	1	Maringer	Maringer	NNP
cord-329876-4cgrjnjo	47	2	&	&	CC
cord-329876-4cgrjnjo	47	3	Fernandez	Fernandez	NNP
cord-329876-4cgrjnjo	47	4	-	-	HYPH
cord-329876-4cgrjnjo	47	5	Sesma	Sesma	NNP
cord-329876-4cgrjnjo	47	6	,	,	,
cord-329876-4cgrjnjo	47	7	2014	2014	CD
cord-329876-4cgrjnjo	47	8	)	)	-RRB-
cord-329876-4cgrjnjo	47	9	.	.	.
cord-329876-4cgrjnjo	48	1	The	the	DT
cord-329876-4cgrjnjo	48	2	PL	PL	NNP
cord-329876-4cgrjnjo	48	3	pro	pro	NN
cord-329876-4cgrjnjo	48	4	has	have	VBZ
cord-329876-4cgrjnjo	48	5	the	the	DT
cord-329876-4cgrjnjo	48	6	ability	ability	NN
cord-329876-4cgrjnjo	48	7	to	to	TO
cord-329876-4cgrjnjo	48	8	digest	digest	VB
cord-329876-4cgrjnjo	48	9	K48-and	K48-and	NNP
cord-329876-4cgrjnjo	49	1	K63-linked	k63-linked	JJ
cord-329876-4cgrjnjo	49	2	polyUb	polyub	NN
cord-329876-4cgrjnjo	49	3	chains	chain	NNS
cord-329876-4cgrjnjo	49	4	and	and	CC
cord-329876-4cgrjnjo	49	5	to	to	TO
cord-329876-4cgrjnjo	49	6	remove	remove	VB
cord-329876-4cgrjnjo	49	7	ISG15	isg15	NN
cord-329876-4cgrjnjo	49	8	from	from	IN
cord-329876-4cgrjnjo	49	9	ISG15-linked	isg15-linked	CD
cord-329876-4cgrjnjo	49	10	proteins	protein	NNS
cord-329876-4cgrjnjo	49	11	(	(	-LRB-
cord-329876-4cgrjnjo	49	12	Baez	Baez	NNP
cord-329876-4cgrjnjo	49	13	-	-	HYPH
cord-329876-4cgrjnjo	49	14	Santos	Santos	NNP
cord-329876-4cgrjnjo	49	15	et	et	NNP
cord-329876-4cgrjnjo	49	16	al	al	NNP
cord-329876-4cgrjnjo	49	17	.	.	NNP
cord-329876-4cgrjnjo	49	18	,	,	,
cord-329876-4cgrjnjo	49	19	2014b	2014b	CD
cord-329876-4cgrjnjo	49	20	)	)	-RRB-
cord-329876-4cgrjnjo	49	21	,	,	,
cord-329876-4cgrjnjo	49	22	thereby	thereby	RB
cord-329876-4cgrjnjo	49	23	interrupting	interrupt	VBG
cord-329876-4cgrjnjo	49	24	the	the	DT
cord-329876-4cgrjnjo	49	25	signalling	signal	VBG
cord-329876-4cgrjnjo	49	26	pathways	pathway	NNS
cord-329876-4cgrjnjo	49	27	leading	lead	VBG
cord-329876-4cgrjnjo	49	28	to	to	IN
cord-329876-4cgrjnjo	49	29	the	the	DT
cord-329876-4cgrjnjo	49	30	innate	innate	JJ
cord-329876-4cgrjnjo	49	31	immune	immune	JJ
cord-329876-4cgrjnjo	49	32	response	response	NN
cord-329876-4cgrjnjo	49	33	.	.	.
cord-329876-4cgrjnjo	50	1	Thus	thus	RB
cord-329876-4cgrjnjo	50	2	,	,	,
cord-329876-4cgrjnjo	50	3	the	the	DT
cord-329876-4cgrjnjo	50	4	PL	pl	NN
cord-329876-4cgrjnjo	50	5	pro	pro	NN
cord-329876-4cgrjnjo	50	6	can	can	MD
cord-329876-4cgrjnjo	50	7	block	block	VB
cord-329876-4cgrjnjo	50	8	the	the	DT
cord-329876-4cgrjnjo	50	9	activation	activation	NN
cord-329876-4cgrjnjo	50	10	of	of	IN
cord-329876-4cgrjnjo	50	11	IFN	IFN	NNP
cord-329876-4cgrjnjo	50	12	regulatory	regulatory	JJ
cord-329876-4cgrjnjo	50	13	factor	factor	NN
cord-329876-4cgrjnjo	50	14	3	3	CD
cord-329876-4cgrjnjo	50	15	(	(	-LRB-
cord-329876-4cgrjnjo	50	16	IRF3	IRF3	NNP
cord-329876-4cgrjnjo	50	17	)	)	-RRB-
cord-329876-4cgrjnjo	51	1	(	(	-LRB-
cord-329876-4cgrjnjo	51	2	Yang	Yang	NNP
cord-329876-4cgrjnjo	51	3	et	et	NNP
cord-329876-4cgrjnjo	51	4	al	al	NNP
cord-329876-4cgrjnjo	51	5	.	.	NNP
cord-329876-4cgrjnjo	51	6	,	,	,
cord-329876-4cgrjnjo	51	7	2013	2013	CD
cord-329876-4cgrjnjo	51	8	)	)	-RRB-
cord-329876-4cgrjnjo	52	1	and	and	CC
cord-329876-4cgrjnjo	52	2	subsequently	subsequently	RB
cord-329876-4cgrjnjo	52	3	the	the	DT
cord-329876-4cgrjnjo	52	4	production	production	NN
cord-329876-4cgrjnjo	52	5	of	of	IN
cord-329876-4cgrjnjo	52	6	interferon	interferon	NN
cord-329876-4cgrjnjo	52	7	β	β	NNP
cord-329876-4cgrjnjo	52	8	(	(	-LRB-
cord-329876-4cgrjnjo	52	9	IFNβ	IFNβ	NNP
cord-329876-4cgrjnjo	52	10	)	)	-RRB-
cord-329876-4cgrjnjo	52	11	(	(	-LRB-
cord-329876-4cgrjnjo	52	12	Mielech	Mielech	NNP
cord-329876-4cgrjnjo	52	13	et	et	NNP
cord-329876-4cgrjnjo	52	14	al	al	NNP
cord-329876-4cgrjnjo	52	15	.	.	NNP
cord-329876-4cgrjnjo	52	16	,	,	,
cord-329876-4cgrjnjo	52	17	2014	2014	CD
cord-329876-4cgrjnjo	52	18	)	)	-RRB-
cord-329876-4cgrjnjo	52	19	.	.	.
cord-329876-4cgrjnjo	53	1	Interestingly	interestingly	RB
cord-329876-4cgrjnjo	53	2	,	,	,
cord-329876-4cgrjnjo	53	3	MERS	MERS	NNP
cord-329876-4cgrjnjo	53	4	-	-	HYPH
cord-329876-4cgrjnjo	53	5	CoV	cov	NN
cord-329876-4cgrjnjo	53	6	PL	pl	NN
cord-329876-4cgrjnjo	54	1	pro	pro	NNP
cord-329876-4cgrjnjo	54	2	shows	show	VBZ
cord-329876-4cgrjnjo	54	3	a	a	DT
cord-329876-4cgrjnjo	54	4	similar	similar	JJ
cord-329876-4cgrjnjo	54	5	cleavage	cleavage	NN
cord-329876-4cgrjnjo	54	6	rate	rate	NN
cord-329876-4cgrjnjo	54	7	for	for	IN
cord-329876-4cgrjnjo	54	8	K48-and	k48-and	NN
cord-329876-4cgrjnjo	55	1	K63-linked	k63-linked	JJ
cord-329876-4cgrjnjo	55	2	polyUb	polyub	NN
cord-329876-4cgrjnjo	55	3	chains	chain	NNS
cord-329876-4cgrjnjo	55	4	,	,	,
cord-329876-4cgrjnjo	55	5	while	while	IN
cord-329876-4cgrjnjo	55	6	the	the	DT
cord-329876-4cgrjnjo	55	7	SARS	SARS	NNP
cord-329876-4cgrjnjo	55	8	-	-	HYPH
cord-329876-4cgrjnjo	55	9	CoV	CoV	NNP
cord-329876-4cgrjnjo	55	10	enzyme	enzyme	NN
cord-329876-4cgrjnjo	55	11	prefers	prefer	VBZ
cord-329876-4cgrjnjo	55	12	K48-over	K48-over	NNP
cord-329876-4cgrjnjo	55	13	K63-linked	K63-linked	NNP
cord-329876-4cgrjnjo	55	14	chains	chain	NNS
cord-329876-4cgrjnjo	55	15	(	(	-LRB-
cord-329876-4cgrjnjo	55	16	Baez	Baez	NNP
cord-329876-4cgrjnjo	55	17	-	-	HYPH
cord-329876-4cgrjnjo	55	18	Santos	Santos	NNP
cord-329876-4cgrjnjo	55	19	et	et	NNP
cord-329876-4cgrjnjo	55	20	al	al	NNP
cord-329876-4cgrjnjo	55	21	.	.	NNP
cord-329876-4cgrjnjo	55	22	,	,	,
cord-329876-4cgrjnjo	55	23	2014b	2014b	CD
cord-329876-4cgrjnjo	55	24	)	)	-RRB-
cord-329876-4cgrjnjo	55	25	.	.	.
cord-329876-4cgrjnjo	56	1	The	the	DT
cord-329876-4cgrjnjo	56	2	former	former	JJ
cord-329876-4cgrjnjo	56	3	enzyme	enzyme	NN
cord-329876-4cgrjnjo	56	4	degrades	degrade	VBZ
cord-329876-4cgrjnjo	56	5	a	a	DT
cord-329876-4cgrjnjo	56	6	polyUb	polyub	NN
cord-329876-4cgrjnjo	56	7	chain	chain	NN
cord-329876-4cgrjnjo	56	8	by	by	IN
cord-329876-4cgrjnjo	56	9	removing	remove	VBG
cord-329876-4cgrjnjo	56	10	mono	mono	NNP
cord-329876-4cgrjnjo	56	11	-	-	HYPH
cord-329876-4cgrjnjo	56	12	Ubs	Ubs	NNP
cord-329876-4cgrjnjo	56	13	,	,	,
cord-329876-4cgrjnjo	56	14	whereas	whereas	IN
cord-329876-4cgrjnjo	56	15	the	the	DT
cord-329876-4cgrjnjo	56	16	latter	latter	JJ
cord-329876-4cgrjnjo	56	17	cleaves	cleave	VBZ
cord-329876-4cgrjnjo	56	18	di	di	NNP
cord-329876-4cgrjnjo	56	19	-	-	HYPH
cord-329876-4cgrjnjo	56	20	Ub	ub	JJ
cord-329876-4cgrjnjo	56	21	units	unit	NNS
cord-329876-4cgrjnjo	56	22	off	off	IN
cord-329876-4cgrjnjo	56	23	the	the	DT
cord-329876-4cgrjnjo	56	24	polyUb	polyub	NN
cord-329876-4cgrjnjo	56	25	chain	chain	NN
cord-329876-4cgrjnjo	57	1	(	(	-LRB-
cord-329876-4cgrjnjo	57	2	Bekes	Bekes	NNP
cord-329876-4cgrjnjo	57	3	et	et	NNP
cord-329876-4cgrjnjo	57	4	al	al	NNP
cord-329876-4cgrjnjo	57	5	.	.	NNP
cord-329876-4cgrjnjo	57	6	,	,	,
cord-329876-4cgrjnjo	57	7	2015	2015	CD
cord-329876-4cgrjnjo	57	8	)	)	-RRB-
cord-329876-4cgrjnjo	57	9	.	.	.
cord-329876-4cgrjnjo	58	1	We	-PRON-	PRP
cord-329876-4cgrjnjo	58	2	have	have	VBP
cord-329876-4cgrjnjo	58	3	reported	report	VBN
cord-329876-4cgrjnjo	58	4	the	the	DT
cord-329876-4cgrjnjo	58	5	first	first	JJ
cord-329876-4cgrjnjo	58	6	crystal	crystal	NN
cord-329876-4cgrjnjo	58	7	structure	structure	NN
cord-329876-4cgrjnjo	58	8	of	of	IN
cord-329876-4cgrjnjo	58	9	the	the	DT
cord-329876-4cgrjnjo	58	10	MERS	MERS	NNP
cord-329876-4cgrjnjo	58	11	-	-	HYPH
cord-329876-4cgrjnjo	58	12	CoV	cov	NN
cord-329876-4cgrjnjo	58	13	PL	pl	NN
cord-329876-4cgrjnjo	58	14	pro	pro	JJ
cord-329876-4cgrjnjo	58	15	(	(	-LRB-
cord-329876-4cgrjnjo	58	16	Lei	lei	FW
cord-329876-4cgrjnjo	58	17	et	et	FW
cord-329876-4cgrjnjo	58	18	al	al	NNP
cord-329876-4cgrjnjo	58	19	.	.	NNP
cord-329876-4cgrjnjo	58	20	,	,	,
cord-329876-4cgrjnjo	58	21	2014	2014	CD
cord-329876-4cgrjnjo	58	22	)	)	-RRB-
cord-329876-4cgrjnjo	58	23	.	.	.
cord-329876-4cgrjnjo	59	1	Later	later	RB
cord-329876-4cgrjnjo	59	2	,	,	,
cord-329876-4cgrjnjo	59	3	two	two	CD
cord-329876-4cgrjnjo	59	4	other	other	JJ
cord-329876-4cgrjnjo	59	5	groups	group	NNS
cord-329876-4cgrjnjo	59	6	also	also	RB
cord-329876-4cgrjnjo	59	7	described	describe	VBD
cord-329876-4cgrjnjo	59	8	the	the	DT
cord-329876-4cgrjnjo	59	9	structure	structure	NN
cord-329876-4cgrjnjo	59	10	of	of	IN
cord-329876-4cgrjnjo	59	11	this	this	DT
cord-329876-4cgrjnjo	59	12	enzyme	enzyme	NN
cord-329876-4cgrjnjo	59	13	(	(	-LRB-
cord-329876-4cgrjnjo	59	14	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	59	15	-	-	HYPH
cord-329876-4cgrjnjo	59	16	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	59	17	et	et	NNP
cord-329876-4cgrjnjo	59	18	al	al	NNP
cord-329876-4cgrjnjo	59	19	.	.	NNP
cord-329876-4cgrjnjo	59	20	,	,	,
cord-329876-4cgrjnjo	59	21	2014	2014	CD
cord-329876-4cgrjnjo	59	22	;	;	:
cord-329876-4cgrjnjo	59	23	Lee	Lee	NNP
cord-329876-4cgrjnjo	59	24	et	et	NNP
cord-329876-4cgrjnjo	59	25	al	al	NNP
cord-329876-4cgrjnjo	59	26	.	.	NNP
cord-329876-4cgrjnjo	59	27	,	,	,
cord-329876-4cgrjnjo	59	28	2015	2015	CD
cord-329876-4cgrjnjo	59	29	)	)	-RRB-
cord-329876-4cgrjnjo	59	30	.	.	.
cord-329876-4cgrjnjo	60	1	The	the	DT
cord-329876-4cgrjnjo	60	2	structure	structure	NN
cord-329876-4cgrjnjo	60	3	of	of	IN
cord-329876-4cgrjnjo	60	4	PL	pl	NN
cord-329876-4cgrjnjo	60	5	pro	pro	NN
cord-329876-4cgrjnjo	60	6	can	can	MD
cord-329876-4cgrjnjo	60	7	be	be	VB
cord-329876-4cgrjnjo	60	8	divided	divide	VBN
cord-329876-4cgrjnjo	60	9	into	into	IN
cord-329876-4cgrjnjo	60	10	two	two	CD
cord-329876-4cgrjnjo	60	11	parts	part	NNS
cord-329876-4cgrjnjo	60	12	:	:	:
cord-329876-4cgrjnjo	60	13	a	a	DT
cord-329876-4cgrjnjo	60	14	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	60	15	-	-	HYPH
cord-329876-4cgrjnjo	60	16	like	like	JJ
cord-329876-4cgrjnjo	60	17	(	(	-LRB-
cord-329876-4cgrjnjo	60	18	Ubl	Ubl	NNP
cord-329876-4cgrjnjo	60	19	)	)	-RRB-
cord-329876-4cgrjnjo	60	20	domain	domain	NN
cord-329876-4cgrjnjo	60	21	and	and	CC
cord-329876-4cgrjnjo	60	22	a	a	DT
cord-329876-4cgrjnjo	60	23	catalytic	catalytic	JJ
cord-329876-4cgrjnjo	60	24	domain	domain	NN
cord-329876-4cgrjnjo	60	25	with	with	IN
cord-329876-4cgrjnjo	60	26	thumb	thumb	NN
cord-329876-4cgrjnjo	60	27	,	,	,
cord-329876-4cgrjnjo	60	28	palm	palm	NN
cord-329876-4cgrjnjo	60	29	,	,	,
cord-329876-4cgrjnjo	60	30	and	and	CC
cord-329876-4cgrjnjo	60	31	fingers	finger	NNS
cord-329876-4cgrjnjo	60	32	subdomains	subdomain	NNS
cord-329876-4cgrjnjo	60	33	.	.	.
cord-329876-4cgrjnjo	61	1	The	the	DT
cord-329876-4cgrjnjo	61	2	overall	overall	JJ
cord-329876-4cgrjnjo	61	3	fold	fold	NN
cord-329876-4cgrjnjo	61	4	of	of	IN
cord-329876-4cgrjnjo	61	5	MERS	MERS	NNP
cord-329876-4cgrjnjo	61	6	-	-	HYPH
cord-329876-4cgrjnjo	61	7	CoV	CoV	NNP
cord-329876-4cgrjnjo	61	8	PL	pl	NN
cord-329876-4cgrjnjo	61	9	pro	pro	NNP
cord-329876-4cgrjnjo	61	10	is	be	VBZ
cord-329876-4cgrjnjo	61	11	not	not	RB
cord-329876-4cgrjnjo	61	12	only	only	RB
cord-329876-4cgrjnjo	61	13	similar	similar	JJ
cord-329876-4cgrjnjo	61	14	to	to	IN
cord-329876-4cgrjnjo	61	15	that	that	DT
cord-329876-4cgrjnjo	61	16	of	of	IN
cord-329876-4cgrjnjo	61	17	SARS	SARS	NNP
cord-329876-4cgrjnjo	61	18	-	-	HYPH
cord-329876-4cgrjnjo	61	19	CoV	CoV	NNP
cord-329876-4cgrjnjo	61	20	PL	PL	NNP
cord-329876-4cgrjnjo	61	21	pro	pro	NN
cord-329876-4cgrjnjo	61	22	,	,	,
cord-329876-4cgrjnjo	61	23	but	but	CC
cord-329876-4cgrjnjo	61	24	also	also	RB
cord-329876-4cgrjnjo	61	25	to	to	IN
cord-329876-4cgrjnjo	61	26	that	that	DT
cord-329876-4cgrjnjo	61	27	of	of	IN
cord-329876-4cgrjnjo	61	28	several	several	JJ
cord-329876-4cgrjnjo	61	29	human	human	JJ
cord-329876-4cgrjnjo	61	30	ubiquitinspecific	ubiquitinspecific	JJ
cord-329876-4cgrjnjo	61	31	proteases	protease	NNS
cord-329876-4cgrjnjo	61	32	(	(	-LRB-
cord-329876-4cgrjnjo	61	33	USPs	USPs	NNP
cord-329876-4cgrjnjo	61	34	)	)	-RRB-
cord-329876-4cgrjnjo	61	35	(	(	-LRB-
cord-329876-4cgrjnjo	61	36	Hu	Hu	NNP
cord-329876-4cgrjnjo	61	37	et	et	FW
cord-329876-4cgrjnjo	61	38	al	al	NNP
cord-329876-4cgrjnjo	61	39	.	.	NNP
cord-329876-4cgrjnjo	61	40	,	,	,
cord-329876-4cgrjnjo	61	41	2005	2005	CD
cord-329876-4cgrjnjo	61	42	)	)	-RRB-
cord-329876-4cgrjnjo	61	43	.	.	.
cord-329876-4cgrjnjo	62	1	In	in	IN
cord-329876-4cgrjnjo	62	2	2014	2014	CD
cord-329876-4cgrjnjo	62	3	,	,	,
cord-329876-4cgrjnjo	62	4	the	the	DT
cord-329876-4cgrjnjo	62	5	X	x	NN
cord-329876-4cgrjnjo	62	6	-	-	NN
cord-329876-4cgrjnjo	62	7	ray	ray	JJ
cord-329876-4cgrjnjo	62	8	structure	structure	NN
cord-329876-4cgrjnjo	62	9	of	of	IN
cord-329876-4cgrjnjo	62	10	the	the	DT
cord-329876-4cgrjnjo	62	11	complex	complex	NN
cord-329876-4cgrjnjo	62	12	of	of	IN
cord-329876-4cgrjnjo	62	13	SARS	SARS	NNP
cord-329876-4cgrjnjo	62	14	-	-	HYPH
cord-329876-4cgrjnjo	62	15	CoV	CoV	NNP
cord-329876-4cgrjnjo	62	16	PL	pl	NN
cord-329876-4cgrjnjo	62	17	pro	pro	JJ
cord-329876-4cgrjnjo	62	18	with	with	IN
cord-329876-4cgrjnjo	62	19	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	62	20	has	have	VBZ
cord-329876-4cgrjnjo	62	21	been	be	VBN
cord-329876-4cgrjnjo	62	22	reported	report	VBN
cord-329876-4cgrjnjo	63	1	(	(	-LRB-
cord-329876-4cgrjnjo	63	2	Chou	Chou	NNP
cord-329876-4cgrjnjo	63	3	et	et	NNP
cord-329876-4cgrjnjo	63	4	al	al	NNP
cord-329876-4cgrjnjo	63	5	.	.	NNP
cord-329876-4cgrjnjo	63	6	,	,	,
cord-329876-4cgrjnjo	63	7	2014	2014	CD
cord-329876-4cgrjnjo	63	8	;	;	:
cord-329876-4cgrjnjo	63	9	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	63	10	et	et	NNP
cord-329876-4cgrjnjo	63	11	al	al	NNP
cord-329876-4cgrjnjo	63	12	.	.	NNP
cord-329876-4cgrjnjo	63	13	,	,	,
cord-329876-4cgrjnjo	63	14	2014	2014	CD
cord-329876-4cgrjnjo	63	15	)	)	-RRB-
cord-329876-4cgrjnjo	63	16	.	.	.
cord-329876-4cgrjnjo	64	1	Several	several	JJ
cord-329876-4cgrjnjo	64	2	key	key	JJ
cord-329876-4cgrjnjo	64	3	residues	residue	NNS
cord-329876-4cgrjnjo	64	4	(	(	-LRB-
cord-329876-4cgrjnjo	64	5	such	such	JJ
cord-329876-4cgrjnjo	64	6	as	as	IN
cord-329876-4cgrjnjo	64	7	Glu168	Glu168	NNP
cord-329876-4cgrjnjo	64	8	or	or	CC
cord-329876-4cgrjnjo	64	9	Tyr265	Tyr265	NNP
cord-329876-4cgrjnjo	64	10	)	)	-RRB-
cord-329876-4cgrjnjo	64	11	of	of	IN
cord-329876-4cgrjnjo	64	12	SARS	SARS	NNP
cord-329876-4cgrjnjo	64	13	-	-	HYPH
cord-329876-4cgrjnjo	64	14	CoV	CoV	NNP
cord-329876-4cgrjnjo	64	15	PL	pl	NN
cord-329876-4cgrjnjo	64	16	pro	pro	JJ
cord-329876-4cgrjnjo	64	17	that	that	WDT
cord-329876-4cgrjnjo	64	18	are	be	VBP
cord-329876-4cgrjnjo	64	19	important	important	JJ
cord-329876-4cgrjnjo	64	20	for	for	IN
cord-329876-4cgrjnjo	64	21	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	64	22	recognition	recognition	NN
cord-329876-4cgrjnjo	65	1	(	(	-LRB-
cord-329876-4cgrjnjo	65	2	Chou	Chou	NNP
cord-329876-4cgrjnjo	65	3	et	et	NNP
cord-329876-4cgrjnjo	65	4	al	al	NNP
cord-329876-4cgrjnjo	65	5	.	.	NNP
cord-329876-4cgrjnjo	65	6	,	,	,
cord-329876-4cgrjnjo	65	7	2014	2014	CD
cord-329876-4cgrjnjo	65	8	;	;	:
cord-329876-4cgrjnjo	65	9	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	65	10	et	et	NNP
cord-329876-4cgrjnjo	65	11	al	al	NNP
cord-329876-4cgrjnjo	65	12	.	.	NNP
cord-329876-4cgrjnjo	65	13	,	,	,
cord-329876-4cgrjnjo	65	14	2014	2014	CD
cord-329876-4cgrjnjo	65	15	)	)	-RRB-
cord-329876-4cgrjnjo	65	16	,	,	,
cord-329876-4cgrjnjo	65	17	are	be	VBP
cord-329876-4cgrjnjo	65	18	not	not	RB
cord-329876-4cgrjnjo	65	19	conserved	conserve	VBN
cord-329876-4cgrjnjo	65	20	in	in	IN
cord-329876-4cgrjnjo	65	21	MERS	MERS	NNP
cord-329876-4cgrjnjo	65	22	-	-	HYPH
cord-329876-4cgrjnjo	65	23	CoV	CoV	NNP
cord-329876-4cgrjnjo	65	24	PL	pl	NN
cord-329876-4cgrjnjo	65	25	pro	pro	NNP
cord-329876-4cgrjnjo	65	26	.	.	.
cord-329876-4cgrjnjo	66	1	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	66	2	-	-	HYPH
cord-329876-4cgrjnjo	66	3	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	66	4	et	et	NNP
cord-329876-4cgrjnjo	66	5	al	al	NNP
cord-329876-4cgrjnjo	66	6	.	.	.
cord-329876-4cgrjnjo	67	1	(	(	-LRB-
cord-329876-4cgrjnjo	67	2	2014	2014	CD
cord-329876-4cgrjnjo	67	3	)	)	-RRB-
cord-329876-4cgrjnjo	67	4	described	describe	VBD
cord-329876-4cgrjnjo	67	5	the	the	DT
cord-329876-4cgrjnjo	67	6	structure	structure	NN
cord-329876-4cgrjnjo	67	7	of	of	IN
cord-329876-4cgrjnjo	67	8	an	an	DT
cord-329876-4cgrjnjo	67	9	artificially	artificially	RB
cord-329876-4cgrjnjo	67	10	linked	link	VBN
cord-329876-4cgrjnjo	67	11	,	,	,
cord-329876-4cgrjnjo	67	12	covalent	covalent	JJ
cord-329876-4cgrjnjo	67	13	complex	complex	NN
cord-329876-4cgrjnjo	67	14	between	between	IN
cord-329876-4cgrjnjo	67	15	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	67	16	and	and	CC
cord-329876-4cgrjnjo	67	17	MERS	MERS	NNP
cord-329876-4cgrjnjo	67	18	-	-	HYPH
cord-329876-4cgrjnjo	67	19	CoV	cov	NN
cord-329876-4cgrjnjo	67	20	PL	pl	NN
cord-329876-4cgrjnjo	67	21	pro	pro	NNP
cord-329876-4cgrjnjo	67	22	.	.	.
cord-329876-4cgrjnjo	68	1	Here	here	RB
cord-329876-4cgrjnjo	68	2	,	,	,
cord-329876-4cgrjnjo	68	3	we	-PRON-	PRP
cord-329876-4cgrjnjo	68	4	present	present	VBP
cord-329876-4cgrjnjo	68	5	the	the	DT
cord-329876-4cgrjnjo	68	6	crystal	crystal	JJ
cord-329876-4cgrjnjo	68	7	structure	structure	NN
cord-329876-4cgrjnjo	68	8	of	of	IN
cord-329876-4cgrjnjo	68	9	a	a	DT
cord-329876-4cgrjnjo	68	10	noncovalent	noncovalent	NN
cord-329876-4cgrjnjo	68	11	complex	complex	NN
cord-329876-4cgrjnjo	68	12	between	between	IN
cord-329876-4cgrjnjo	68	13	the	the	DT
cord-329876-4cgrjnjo	68	14	two	two	CD
cord-329876-4cgrjnjo	68	15	proteins	protein	NNS
cord-329876-4cgrjnjo	68	16	and	and	CC
cord-329876-4cgrjnjo	68	17	a	a	DT
cord-329876-4cgrjnjo	68	18	mutational	mutational	JJ
cord-329876-4cgrjnjo	68	19	study	study	NN
cord-329876-4cgrjnjo	68	20	of	of	IN
cord-329876-4cgrjnjo	68	21	the	the	DT
cord-329876-4cgrjnjo	68	22	interactions	interaction	NNS
cord-329876-4cgrjnjo	68	23	involved	involve	VBN
cord-329876-4cgrjnjo	68	24	.	.	.
cord-329876-4cgrjnjo	69	1	For	for	IN
cord-329876-4cgrjnjo	69	2	these	these	DT
cord-329876-4cgrjnjo	69	3	studies	study	NNS
cord-329876-4cgrjnjo	69	4	,	,	,
cord-329876-4cgrjnjo	69	5	we	-PRON-	PRP
cord-329876-4cgrjnjo	69	6	used	use	VBD
cord-329876-4cgrjnjo	69	7	the	the	DT
cord-329876-4cgrjnjo	69	8	Cys111Ser	Cys111Ser	NNP
cord-329876-4cgrjnjo	69	9	active	active	JJ
cord-329876-4cgrjnjo	69	10	-	-	HYPH
cord-329876-4cgrjnjo	69	11	site	site	NN
cord-329876-4cgrjnjo	69	12	variant	variant	NN
cord-329876-4cgrjnjo	69	13	of	of	IN
cord-329876-4cgrjnjo	69	14	MERS	MERS	NNP
cord-329876-4cgrjnjo	69	15	-	-	HYPH
cord-329876-4cgrjnjo	69	16	CoV	CoV	NNP
cord-329876-4cgrjnjo	69	17	PL	pl	NN
cord-329876-4cgrjnjo	69	18	pro	pro	NNP
cord-329876-4cgrjnjo	69	19	.	.	.
cord-329876-4cgrjnjo	70	1	The	the	DT
cord-329876-4cgrjnjo	70	2	PL	PL	NNP
cord-329876-4cgrjnjo	70	3	pro	pro	NN
cord-329876-4cgrjnjo	70	4	of	of	IN
cord-329876-4cgrjnjo	70	5	MERS	MERS	NNP
cord-329876-4cgrjnjo	70	6	-	-	HYPH
cord-329876-4cgrjnjo	70	7	CoV	CoV	NNP
cord-329876-4cgrjnjo	70	8	(	(	-LRB-
cord-329876-4cgrjnjo	70	9	strain	strain	NN
cord-329876-4cgrjnjo	70	10	2c	2c	NNP
cord-329876-4cgrjnjo	70	11	EMC/2012	EMC/2012	NNP
cord-329876-4cgrjnjo	70	12	;	;	:
cord-329876-4cgrjnjo	70	13	Gen	Gen	NNP
cord-329876-4cgrjnjo	70	14	-	-	HYPH
cord-329876-4cgrjnjo	70	15	Bank	Bank	NNP
cord-329876-4cgrjnjo	71	1	no	no	UH
cord-329876-4cgrjnjo	71	2	.	.	.
cord-329876-4cgrjnjo	72	1	AFV09327.1	AFV09327.1	NNP
cord-329876-4cgrjnjo	72	2	)	)	-RRB-
cord-329876-4cgrjnjo	72	3	contains	contain	VBZ
cord-329876-4cgrjnjo	72	4	320	320	CD
cord-329876-4cgrjnjo	72	5	residues	residue	NNS
cord-329876-4cgrjnjo	72	6	,	,	,
cord-329876-4cgrjnjo	72	7	from	from	IN
cord-329876-4cgrjnjo	72	8	Gln1482	Gln1482	NNP
cord-329876-4cgrjnjo	72	9	to	to	IN
cord-329876-4cgrjnjo	72	10	Asp1801	Asp1801	NNP
cord-329876-4cgrjnjo	72	11	of	of	IN
cord-329876-4cgrjnjo	72	12	pp1a/1ab	pp1a/1ab	NNP
cord-329876-4cgrjnjo	72	13	.	.	.
cord-329876-4cgrjnjo	73	1	For	for	IN
cord-329876-4cgrjnjo	73	2	simplification	simplification	NN
cord-329876-4cgrjnjo	73	3	,	,	,
cord-329876-4cgrjnjo	73	4	Gln1482	Gln1482	NNP
cord-329876-4cgrjnjo	73	5	was	be	VBD
cord-329876-4cgrjnjo	73	6	renumbered	renumbere	VBN
cord-329876-4cgrjnjo	73	7	into	into	IN
cord-329876-4cgrjnjo	73	8	Gln1	Gln1	NNP
cord-329876-4cgrjnjo	73	9	here	here	RB
cord-329876-4cgrjnjo	73	10	.	.	.
cord-329876-4cgrjnjo	74	1	The	the	DT
cord-329876-4cgrjnjo	74	2	DNA	dna	NN
cord-329876-4cgrjnjo	74	3	plasmid	plasmid	NN
cord-329876-4cgrjnjo	74	4	coding	coding	NN
cord-329876-4cgrjnjo	74	5	for	for	IN
cord-329876-4cgrjnjo	74	6	MERS	MERS	NNP
cord-329876-4cgrjnjo	74	7	-	-	HYPH
cord-329876-4cgrjnjo	74	8	CoV	cov	NN
cord-329876-4cgrjnjo	74	9	PL	pl	NN
cord-329876-4cgrjnjo	74	10	pro	pro	NNP
cord-329876-4cgrjnjo	74	11	was	be	VBD
cord-329876-4cgrjnjo	74	12	produced	produce	VBN
cord-329876-4cgrjnjo	74	13	earlier	early	RBR
cord-329876-4cgrjnjo	75	1	(	(	-LRB-
cord-329876-4cgrjnjo	75	2	Lei	Lei	NNP
cord-329876-4cgrjnjo	75	3	et	et	FW
cord-329876-4cgrjnjo	75	4	al	al	NNP
cord-329876-4cgrjnjo	75	5	.	.	NNP
cord-329876-4cgrjnjo	75	6	,	,	,
cord-329876-4cgrjnjo	75	7	2014	2014	CD
cord-329876-4cgrjnjo	75	8	)	)	-RRB-
cord-329876-4cgrjnjo	75	9	.	.	.
cord-329876-4cgrjnjo	76	1	The	the	DT
cord-329876-4cgrjnjo	76	2	MERS	MERS	NNP
cord-329876-4cgrjnjo	76	3	-	-	HYPH
cord-329876-4cgrjnjo	76	4	CoV	cov	NN
cord-329876-4cgrjnjo	76	5	PL	pl	NN
cord-329876-4cgrjnjo	76	6	pro	pro	JJ
cord-329876-4cgrjnjo	76	7	C111S	C111S	NNP
cord-329876-4cgrjnjo	76	8	,	,	,
cord-329876-4cgrjnjo	76	9	D164E	D164E	NNP
cord-329876-4cgrjnjo	76	10	,	,	,
cord-329876-4cgrjnjo	76	11	D164A	D164A	NNPS
cord-329876-4cgrjnjo	76	12	,	,	,
cord-329876-4cgrjnjo	76	13	D165E	D165E	NNP
cord-329876-4cgrjnjo	76	14	,	,	,
cord-329876-4cgrjnjo	76	15	D165A	D165A	NNS
cord-329876-4cgrjnjo	76	16	,	,	,
cord-329876-4cgrjnjo	76	17	and	and	CC
cord-329876-4cgrjnjo	76	18	F269Y	F269Y	NNS
cord-329876-4cgrjnjo	76	19	variants	variant	NNS
cord-329876-4cgrjnjo	76	20	were	be	VBD
cord-329876-4cgrjnjo	76	21	produced	produce	VBN
cord-329876-4cgrjnjo	76	22	using	use	VBG
cord-329876-4cgrjnjo	76	23	the	the	DT
cord-329876-4cgrjnjo	76	24	same	same	JJ
cord-329876-4cgrjnjo	76	25	strategy	strategy	NN
cord-329876-4cgrjnjo	76	26	that	that	WDT
cord-329876-4cgrjnjo	76	27	we	-PRON-	PRP
cord-329876-4cgrjnjo	76	28	described	describe	VBD
cord-329876-4cgrjnjo	76	29	before	before	IN
cord-329876-4cgrjnjo	76	30	(	(	-LRB-
cord-329876-4cgrjnjo	76	31	Lei	Lei	NNP
cord-329876-4cgrjnjo	76	32	et	et	FW
cord-329876-4cgrjnjo	76	33	al	al	NNP
cord-329876-4cgrjnjo	76	34	.	.	.
cord-329876-4cgrjnjo	77	1	,	,	,
cord-329876-4cgrjnjo	77	2	2014	2014	CD
cord-329876-4cgrjnjo	77	3	)	)	-RRB-
cord-329876-4cgrjnjo	77	4	.	.	.
cord-329876-4cgrjnjo	78	1	All	all	DT
cord-329876-4cgrjnjo	78	2	primers	primer	NNS
cord-329876-4cgrjnjo	78	3	for	for	IN
cord-329876-4cgrjnjo	78	4	these	these	DT
cord-329876-4cgrjnjo	78	5	variants	variant	NNS
cord-329876-4cgrjnjo	78	6	are	be	VBP
cord-329876-4cgrjnjo	78	7	listed	list	VBN
cord-329876-4cgrjnjo	78	8	in	in	IN
cord-329876-4cgrjnjo	78	9	Supplemental	supplemental	JJ
cord-329876-4cgrjnjo	78	10	 	 	_SP
cord-329876-4cgrjnjo	78	11	Table	Table	NNP
cord-329876-4cgrjnjo	78	12	S1	S1	NNP
cord-329876-4cgrjnjo	78	13	.	.	.
cord-329876-4cgrjnjo	79	1	All	all	DT
cord-329876-4cgrjnjo	79	2	DNA	dna	NN
cord-329876-4cgrjnjo	79	3	plasmids	plasmid	NNS
cord-329876-4cgrjnjo	79	4	coding	code	VBG
cord-329876-4cgrjnjo	79	5	for	for	IN
cord-329876-4cgrjnjo	79	6	the	the	DT
cord-329876-4cgrjnjo	79	7	altered	alter	VBN
cord-329876-4cgrjnjo	79	8	PL	pl	NN
cord-329876-4cgrjnjo	79	9	pro	pro	JJ
cord-329876-4cgrjnjo	79	10	were	be	VBD
cord-329876-4cgrjnjo	79	11	verified	verify	VBN
cord-329876-4cgrjnjo	79	12	by	by	IN
cord-329876-4cgrjnjo	79	13	sequencing	sequence	VBG
cord-329876-4cgrjnjo	79	14	.	.	.
cord-329876-4cgrjnjo	80	1	Genes	gene	NNS
cord-329876-4cgrjnjo	80	2	coding	code	VBG
cord-329876-4cgrjnjo	80	3	for	for	IN
cord-329876-4cgrjnjo	80	4	wild	wild	JJ
cord-329876-4cgrjnjo	80	5	-	-	HYPH
cord-329876-4cgrjnjo	80	6	type	type	NN
cord-329876-4cgrjnjo	80	7	(	(	-LRB-
cord-329876-4cgrjnjo	80	8	WT	WT	NNP
cord-329876-4cgrjnjo	80	9	)	)	-RRB-
cord-329876-4cgrjnjo	80	10	MERS	MERS	NNP
cord-329876-4cgrjnjo	80	11	-	-	HYPH
cord-329876-4cgrjnjo	80	12	CoV	cov	NN
cord-329876-4cgrjnjo	80	13	PL	pl	NN
cord-329876-4cgrjnjo	80	14	pro	pro	NNP
cord-329876-4cgrjnjo	80	15	and	and	CC
cord-329876-4cgrjnjo	80	16	for	for	IN
cord-329876-4cgrjnjo	80	17	its	-PRON-	PRP$
cord-329876-4cgrjnjo	80	18	variants	variant	NNS
cord-329876-4cgrjnjo	80	19	were	be	VBD
cord-329876-4cgrjnjo	80	20	expressed	express	VBN
cord-329876-4cgrjnjo	80	21	and	and	CC
cord-329876-4cgrjnjo	80	22	the	the	DT
cord-329876-4cgrjnjo	80	23	corresponding	correspond	VBG
cord-329876-4cgrjnjo	80	24	proteins	protein	NNS
cord-329876-4cgrjnjo	80	25	were	be	VBD
cord-329876-4cgrjnjo	80	26	purified	purify	VBN
cord-329876-4cgrjnjo	80	27	according	accord	VBG
cord-329876-4cgrjnjo	80	28	to	to	IN
cord-329876-4cgrjnjo	80	29	our	-PRON-	PRP$
cord-329876-4cgrjnjo	80	30	previous	previous	JJ
cord-329876-4cgrjnjo	80	31	description	description	NN
cord-329876-4cgrjnjo	80	32	(	(	-LRB-
cord-329876-4cgrjnjo	80	33	Lei	Lei	NNP
cord-329876-4cgrjnjo	80	34	et	et	FW
cord-329876-4cgrjnjo	80	35	al	al	NNP
cord-329876-4cgrjnjo	80	36	.	.	NNP
cord-329876-4cgrjnjo	80	37	,	,	,
cord-329876-4cgrjnjo	80	38	2014	2014	CD
cord-329876-4cgrjnjo	80	39	)	)	-RRB-
cord-329876-4cgrjnjo	80	40	.	.	.
cord-329876-4cgrjnjo	81	1	performed	perform	VBN
cord-329876-4cgrjnjo	81	2	according	accord	VBG
cord-329876-4cgrjnjo	81	3	to	to	IN
cord-329876-4cgrjnjo	81	4	the	the	DT
cord-329876-4cgrjnjo	81	5	procedure	procedure	NN
cord-329876-4cgrjnjo	81	6	described	describe	VBN
cord-329876-4cgrjnjo	81	7	for	for	IN
cord-329876-4cgrjnjo	81	8	MERS	MERS	NNP
cord-329876-4cgrjnjo	81	9	-	-	HYPH
cord-329876-4cgrjnjo	81	10	CoV	cov	NN
cord-329876-4cgrjnjo	81	11	PL	pl	NN
cord-329876-4cgrjnjo	81	12	pro	pro	JJ
cord-329876-4cgrjnjo	81	13	(	(	-LRB-
cord-329876-4cgrjnjo	81	14	Lei	lei	FW
cord-329876-4cgrjnjo	81	15	et	et	FW
cord-329876-4cgrjnjo	81	16	al	al	NNP
cord-329876-4cgrjnjo	81	17	.	.	NNP
cord-329876-4cgrjnjo	81	18	,	,	,
cord-329876-4cgrjnjo	81	19	2014	2014	CD
cord-329876-4cgrjnjo	81	20	)	)	-RRB-
cord-329876-4cgrjnjo	81	21	.	.	.
cord-329876-4cgrjnjo	82	1	Purified	purify	VBN
cord-329876-4cgrjnjo	82	2	MERS	MERS	NNP
cord-329876-4cgrjnjo	82	3	-	-	HYPH
cord-329876-4cgrjnjo	82	4	CoV	cov	NN
cord-329876-4cgrjnjo	82	5	PL	pl	NN
cord-329876-4cgrjnjo	82	6	pro	pro	JJ
cord-329876-4cgrjnjo	82	7	(	(	-LRB-
cord-329876-4cgrjnjo	82	8	WT	WT	NNP
cord-329876-4cgrjnjo	82	9	)	)	-RRB-
cord-329876-4cgrjnjo	82	10	and	and	CC
cord-329876-4cgrjnjo	82	11	a	a	DT
cord-329876-4cgrjnjo	82	12	variant	variant	NN
cord-329876-4cgrjnjo	82	13	that	that	WDT
cord-329876-4cgrjnjo	82	14	had	have	VBD
cord-329876-4cgrjnjo	82	15	the	the	DT
cord-329876-4cgrjnjo	82	16	active	active	JJ
cord-329876-4cgrjnjo	82	17	-	-	HYPH
cord-329876-4cgrjnjo	82	18	site	site	NN
cord-329876-4cgrjnjo	82	19	Cys111	cys111	CD
cord-329876-4cgrjnjo	82	20	replaced	replace	VBN
cord-329876-4cgrjnjo	82	21	by	by	IN
cord-329876-4cgrjnjo	82	22	Ser	Ser	NNP
cord-329876-4cgrjnjo	82	23	(	(	-LRB-
cord-329876-4cgrjnjo	82	24	PL	pl	NN
cord-329876-4cgrjnjo	82	25	pro	pro	JJ
cord-329876-4cgrjnjo	82	26	(	(	-LRB-
cord-329876-4cgrjnjo	82	27	C111S	C111S	NNP
cord-329876-4cgrjnjo	82	28	)	)	-RRB-
cord-329876-4cgrjnjo	82	29	)	)	-RRB-
cord-329876-4cgrjnjo	82	30	were	be	VBD
cord-329876-4cgrjnjo	82	31	both	both	DT
cord-329876-4cgrjnjo	82	32	concentrated	concentrated	JJ
cord-329876-4cgrjnjo	82	33	to	to	IN
cord-329876-4cgrjnjo	82	34	~24	~24	NNP
cord-329876-4cgrjnjo	82	35	mg	mg	NN
cord-329876-4cgrjnjo	82	36	/	/	SYM
cord-329876-4cgrjnjo	82	37	mL	ml	NN
cord-329876-4cgrjnjo	82	38	in	in	IN
cord-329876-4cgrjnjo	82	39	20	20	CD
cord-329876-4cgrjnjo	82	40	mmol	mmol	JJ
cord-329876-4cgrjnjo	82	41	/	/	SYM
cord-329876-4cgrjnjo	82	42	L	L	NNP
cord-329876-4cgrjnjo	82	43	Tris	Tris	NNP
cord-329876-4cgrjnjo	82	44	-	-	HYPH
cord-329876-4cgrjnjo	82	45	HCl	HCl	NNP
cord-329876-4cgrjnjo	82	46	,	,	,
cord-329876-4cgrjnjo	82	47	150	150	CD
cord-329876-4cgrjnjo	82	48	mmol	mmol	JJ
cord-329876-4cgrjnjo	82	49	/	/	SYM
cord-329876-4cgrjnjo	82	50	L	L	NNP
cord-329876-4cgrjnjo	82	51	NaCl	NaCl	NNP
cord-329876-4cgrjnjo	82	52	,	,	,
cord-329876-4cgrjnjo	82	53	pH	pH	NNP
cord-329876-4cgrjnjo	82	54	8.8	8.8	CD
cord-329876-4cgrjnjo	82	55	,	,	,
cord-329876-4cgrjnjo	82	56	10	10	CD
cord-329876-4cgrjnjo	82	57	mmol	mmol	JJ
cord-329876-4cgrjnjo	82	58	/	/	SYM
cord-329876-4cgrjnjo	82	59	L	L	NNP
cord-329876-4cgrjnjo	82	60	β	β	NNP
cord-329876-4cgrjnjo	82	61	-	-	HYPH
cord-329876-4cgrjnjo	82	62	mercaptoethanol	mercaptoethanol	JJ
cord-329876-4cgrjnjo	82	63	(	(	-LRB-
cord-329876-4cgrjnjo	82	64	BME	BME	NNP
cord-329876-4cgrjnjo	82	65	)	)	-RRB-
cord-329876-4cgrjnjo	82	66	.	.	.
cord-329876-4cgrjnjo	83	1	Human	human	JJ
cord-329876-4cgrjnjo	83	2	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	83	3	(	(	-LRB-
cord-329876-4cgrjnjo	83	4	BostonBiochem	BostonBiochem	NNP
cord-329876-4cgrjnjo	83	5	)	)	-RRB-
cord-329876-4cgrjnjo	83	6	was	be	VBD
cord-329876-4cgrjnjo	83	7	dissolved	dissolve	VBN
cord-329876-4cgrjnjo	83	8	to	to	IN
cord-329876-4cgrjnjo	83	9	6	6	CD
cord-329876-4cgrjnjo	83	10	mg	mg	NN
cord-329876-4cgrjnjo	83	11	/	/	SYM
cord-329876-4cgrjnjo	83	12	mL	ml	NN
cord-329876-4cgrjnjo	83	13	in	in	IN
cord-329876-4cgrjnjo	83	14	20	20	CD
cord-329876-4cgrjnjo	83	15	mmol	mmol	JJ
cord-329876-4cgrjnjo	83	16	/	/	SYM
cord-329876-4cgrjnjo	83	17	L	L	NNP
cord-329876-4cgrjnjo	83	18	Tris	Tris	NNP
cord-329876-4cgrjnjo	83	19	-	-	HYPH
cord-329876-4cgrjnjo	83	20	HCl	HCl	NNP
cord-329876-4cgrjnjo	83	21	,	,	,
cord-329876-4cgrjnjo	83	22	150	150	CD
cord-329876-4cgrjnjo	83	23	mmol	mmol	JJ
cord-329876-4cgrjnjo	83	24	/	/	SYM
cord-329876-4cgrjnjo	83	25	L	L	NNP
cord-329876-4cgrjnjo	83	26	NaCl	NaCl	NNP
cord-329876-4cgrjnjo	83	27	,	,	,
cord-329876-4cgrjnjo	83	28	pH	pH	NNP
cord-329876-4cgrjnjo	83	29	8.8	8.8	CD
cord-329876-4cgrjnjo	83	30	.	.	.
cord-329876-4cgrjnjo	84	1	500	500	CD
cord-329876-4cgrjnjo	85	1	μL	μL	NFP
cord-329876-4cgrjnjo	85	2	PL	pl	NN
cord-329876-4cgrjnjo	85	3	pro	pro	FW
cord-329876-4cgrjnjo	85	4	(	(	-LRB-
cord-329876-4cgrjnjo	85	5	WT	WT	NNP
cord-329876-4cgrjnjo	85	6	)	)	-RRB-
cord-329876-4cgrjnjo	85	7	or	or	CC
cord-329876-4cgrjnjo	85	8	PL	pl	NN
cord-329876-4cgrjnjo	85	9	pro	pro	JJ
cord-329876-4cgrjnjo	85	10	(	(	-LRB-
cord-329876-4cgrjnjo	85	11	C111S	C111S	NNP
cord-329876-4cgrjnjo	85	12	)	)	-RRB-
cord-329876-4cgrjnjo	85	13	were	be	VBD
cord-329876-4cgrjnjo	85	14	mixed	mix	VBN
cord-329876-4cgrjnjo	85	15	with	with	IN
cord-329876-4cgrjnjo	85	16	500	500	CD
cord-329876-4cgrjnjo	85	17	μL	μl	NN
cord-329876-4cgrjnjo	85	18	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	85	19	(	(	-LRB-
cord-329876-4cgrjnjo	85	20	~1:1	~1:1	NFP
cord-329876-4cgrjnjo	85	21	molar	molar	JJ
cord-329876-4cgrjnjo	85	22	ratio	ratio	NN
cord-329876-4cgrjnjo	85	23	)	)	-RRB-
cord-329876-4cgrjnjo	85	24	at	at	IN
cord-329876-4cgrjnjo	85	25	4	4	CD
cord-329876-4cgrjnjo	85	26	°	°	NN
cord-329876-4cgrjnjo	85	27	C	c	NN
cord-329876-4cgrjnjo	85	28	overnight	overnight	RB
cord-329876-4cgrjnjo	85	29	.	.	.
cord-329876-4cgrjnjo	86	1	(	(	-LRB-
cord-329876-4cgrjnjo	86	2	C111S)-Ub	c111s)-ub	NN
cord-329876-4cgrjnjo	86	3	were	be	VBD
cord-329876-4cgrjnjo	86	4	observed	observe	VBN
cord-329876-4cgrjnjo	86	5	under	under	IN
cord-329876-4cgrjnjo	86	6	condition	condition	NN
cord-329876-4cgrjnjo	87	1	No	no	UH
cord-329876-4cgrjnjo	87	2	.	.	NN
cord-329876-4cgrjnjo	87	3	9	9	CD
cord-329876-4cgrjnjo	87	4	of	of	IN
cord-329876-4cgrjnjo	87	5	MD1	MD1	NNP
cord-329876-4cgrjnjo	87	6	-	-	HYPH
cord-329876-4cgrjnjo	87	7	01	01	CD
cord-329876-4cgrjnjo	87	8	,	,	,
cord-329876-4cgrjnjo	87	9	whereas	whereas	IN
cord-329876-4cgrjnjo	87	10	no	no	DT
cord-329876-4cgrjnjo	87	11	crystal	crystal	NN
cord-329876-4cgrjnjo	87	12	of	of	IN
cord-329876-4cgrjnjo	87	13	PL	pl	NN
cord-329876-4cgrjnjo	87	14	pro	pro	JJ
cord-329876-4cgrjnjo	87	15	(	(	-LRB-
cord-329876-4cgrjnjo	87	16	WT)-Ub	wt)-ub	NN
cord-329876-4cgrjnjo	87	17	was	be	VBD
cord-329876-4cgrjnjo	87	18	obtained	obtain	VBN
cord-329876-4cgrjnjo	87	19	.	.	.
cord-329876-4cgrjnjo	88	1	Optimized	optimize	VBN
cord-329876-4cgrjnjo	88	2	crystals	crystal	NNS
cord-329876-4cgrjnjo	88	3	of	of	IN
cord-329876-4cgrjnjo	88	4	PL	pl	NN
cord-329876-4cgrjnjo	88	5	pro	pro	JJ
cord-329876-4cgrjnjo	88	6	(	(	-LRB-
cord-329876-4cgrjnjo	88	7	C111S)-Ub	c111s)-ub	NN
cord-329876-4cgrjnjo	88	8	were	be	VBD
cord-329876-4cgrjnjo	88	9	subsequently	subsequently	RB
cord-329876-4cgrjnjo	88	10	obtained	obtain	VBN
cord-329876-4cgrjnjo	88	11	within	within	IN
cord-329876-4cgrjnjo	88	12	two	two	CD
cord-329876-4cgrjnjo	88	13	days	day	NNS
cord-329876-4cgrjnjo	88	14	under	under	IN
cord-329876-4cgrjnjo	88	15	the	the	DT
cord-329876-4cgrjnjo	88	16	condition	condition	NN
cord-329876-4cgrjnjo	88	17	:	:	:
cord-329876-4cgrjnjo	88	18	22	22	CD
cord-329876-4cgrjnjo	88	19	%	%	NN
cord-329876-4cgrjnjo	88	20	w	w	NN
cord-329876-4cgrjnjo	88	21	/	/	SYM
cord-329876-4cgrjnjo	88	22	v	v	NN
cord-329876-4cgrjnjo	88	23	PEG	PEG	NNP
cord-329876-4cgrjnjo	88	24	4000	4000	CD
cord-329876-4cgrjnjo	88	25	,	,	,
cord-329876-4cgrjnjo	88	26	15	15	CD
cord-329876-4cgrjnjo	88	27	%	%	NN
cord-329876-4cgrjnjo	88	28	v	v	NN
cord-329876-4cgrjnjo	88	29	/	/	SYM
cord-329876-4cgrjnjo	88	30	v	v	NN
cord-329876-4cgrjnjo	88	31	2-propanol	2-propanol	CD
cord-329876-4cgrjnjo	88	32	,	,	,
cord-329876-4cgrjnjo	88	33	0.1	0.1	CD
cord-329876-4cgrjnjo	88	34	mol	mol	NN
cord-329876-4cgrjnjo	88	35	/	/	SYM
cord-329876-4cgrjnjo	88	36	L	L	NNP
cord-329876-4cgrjnjo	88	37	tri	tri	JJ
cord-329876-4cgrjnjo	88	38	-	-	JJ
cord-329876-4cgrjnjo	88	39	sodium	sodium	JJ
cord-329876-4cgrjnjo	88	40	citrate	citrate	NN
cord-329876-4cgrjnjo	88	41	pH	pH	NNP
cord-329876-4cgrjnjo	88	42	4.8	4.8	CD
cord-329876-4cgrjnjo	88	43	,	,	,
cord-329876-4cgrjnjo	88	44	and	and	CC
cord-329876-4cgrjnjo	88	45	10	10	CD
cord-329876-4cgrjnjo	88	46	%	%	NN
cord-329876-4cgrjnjo	88	47	glycerol	glycerol	NN
cord-329876-4cgrjnjo	88	48	.	.	.
cord-329876-4cgrjnjo	89	1	2	2	LS
cord-329876-4cgrjnjo	89	2	μL	μl	NN
cord-329876-4cgrjnjo	89	3	of	of	IN
cord-329876-4cgrjnjo	89	4	protein	protein	NN
cord-329876-4cgrjnjo	89	5	and	and	CC
cord-329876-4cgrjnjo	89	6	2.5	2.5	CD
cord-329876-4cgrjnjo	89	7	μL	μL	NNS
cord-329876-4cgrjnjo	89	8	of	of	IN
cord-329876-4cgrjnjo	89	9	reservoir	reservoir	NN
cord-329876-4cgrjnjo	89	10	were	be	VBD
cord-329876-4cgrjnjo	89	11	mixed	mixed	JJ
cord-329876-4cgrjnjo	89	12	to	to	TO
cord-329876-4cgrjnjo	89	13	equilibrate	equilibrate	VB
cord-329876-4cgrjnjo	89	14	against	against	IN
cord-329876-4cgrjnjo	89	15	500	500	CD
cord-329876-4cgrjnjo	89	16	μL	μL	NNP
cord-329876-4cgrjnjo	89	17	reservoir	reservoir	NN
cord-329876-4cgrjnjo	89	18	.	.	.
cord-329876-4cgrjnjo	90	1	Crystals	crystal	NNS
cord-329876-4cgrjnjo	90	2	were	be	VBD
cord-329876-4cgrjnjo	90	3	placed	place	VBN
cord-329876-4cgrjnjo	90	4	in	in	IN
cord-329876-4cgrjnjo	90	5	a	a	DT
cord-329876-4cgrjnjo	90	6	nitrogen	nitrogen	NN
cord-329876-4cgrjnjo	90	7	-	-	HYPH
cord-329876-4cgrjnjo	90	8	gas	gas	NN
cord-329876-4cgrjnjo	90	9	stream	stream	NN
cord-329876-4cgrjnjo	90	10	(	(	-LRB-
cord-329876-4cgrjnjo	90	11	100	100	CD
cord-329876-4cgrjnjo	90	12	K	K	NNP
cord-329876-4cgrjnjo	90	13	)	)	-RRB-
cord-329876-4cgrjnjo	90	14	.	.	.
cord-329876-4cgrjnjo	91	1	A	a	DT
cord-329876-4cgrjnjo	91	2	3.16-Å	3.16-å	CD
cord-329876-4cgrjnjo	91	3	dataset	dataset	NN
cord-329876-4cgrjnjo	91	4	was	be	VBD
cord-329876-4cgrjnjo	91	5	collected	collect	VBN
cord-329876-4cgrjnjo	91	6	at	at	IN
cord-329876-4cgrjnjo	91	7	wavelength	wavelength	NN
cord-329876-4cgrjnjo	91	8	0.91841	0.91841	CD
cord-329876-4cgrjnjo	91	9	Å	å	NN
cord-329876-4cgrjnjo	91	10	at	at	IN
cord-329876-4cgrjnjo	91	11	beamline	beamline	NN
cord-329876-4cgrjnjo	91	12	14.2	14.2	CD
cord-329876-4cgrjnjo	91	13	of	of	IN
cord-329876-4cgrjnjo	91	14	BESSY	BESSY	NNP
cord-329876-4cgrjnjo	91	15	,	,	,
cord-329876-4cgrjnjo	91	16	Berlin	Berlin	NNP
cord-329876-4cgrjnjo	92	1	(	(	-LRB-
cord-329876-4cgrjnjo	92	2	Mueller	Mueller	NNP
cord-329876-4cgrjnjo	92	3	et	et	NNP
cord-329876-4cgrjnjo	92	4	al	al	NNP
cord-329876-4cgrjnjo	92	5	.	.	NNP
cord-329876-4cgrjnjo	92	6	,	,	,
cord-329876-4cgrjnjo	92	7	2012	2012	CD
cord-329876-4cgrjnjo	92	8	)	)	-RRB-
cord-329876-4cgrjnjo	92	9	.	.	.
cord-329876-4cgrjnjo	93	1	The	the	DT
cord-329876-4cgrjnjo	93	2	program	program	NN
cord-329876-4cgrjnjo	93	3	XDS	XDS	NNP
cord-329876-4cgrjnjo	93	4	(	(	-LRB-
cord-329876-4cgrjnjo	93	5	Kabsch	Kabsch	NNP
cord-329876-4cgrjnjo	93	6	,	,	,
cord-329876-4cgrjnjo	93	7	2010	2010	CD
cord-329876-4cgrjnjo	93	8	)	)	-RRB-
cord-329876-4cgrjnjo	93	9	was	be	VBD
cord-329876-4cgrjnjo	93	10	used	use	VBN
cord-329876-4cgrjnjo	93	11	to	to	TO
cord-329876-4cgrjnjo	93	12	process	process	VB
cord-329876-4cgrjnjo	93	13	the	the	DT
cord-329876-4cgrjnjo	93	14	diffraction	diffraction	NN
cord-329876-4cgrjnjo	93	15	data	datum	NNS
cord-329876-4cgrjnjo	93	16	.	.	.
cord-329876-4cgrjnjo	94	1	The	the	DT
cord-329876-4cgrjnjo	94	2	space	space	NN
cord-329876-4cgrjnjo	94	3	group	group	NN
cord-329876-4cgrjnjo	94	4	was	be	VBD
cord-329876-4cgrjnjo	94	5	found	find	VBN
cord-329876-4cgrjnjo	94	6	to	to	TO
cord-329876-4cgrjnjo	94	7	be	be	VB
cord-329876-4cgrjnjo	94	8	P6	p6	NN
cord-329876-4cgrjnjo	94	9	3	3	CD
cord-329876-4cgrjnjo	94	10	,	,	,
cord-329876-4cgrjnjo	94	11	with	with	IN
cord-329876-4cgrjnjo	94	12	unit	unit	NN
cord-329876-4cgrjnjo	94	13	-	-	HYPH
cord-329876-4cgrjnjo	94	14	cell	cell	NN
cord-329876-4cgrjnjo	94	15	parameters	parameter	NNS
cord-329876-4cgrjnjo	94	16	a	a	DT
cord-329876-4cgrjnjo	94	17	=	=	SYM
cord-329876-4cgrjnjo	94	18	b	b	NN
cord-329876-4cgrjnjo	94	19	=	=	SYM
cord-329876-4cgrjnjo	94	20	138.14	138.14	CD
cord-329876-4cgrjnjo	94	21	Å	å	NN
cord-329876-4cgrjnjo	94	22	,	,	,
cord-329876-4cgrjnjo	94	23	c	c	NN
cord-329876-4cgrjnjo	94	24	=	=	SYM
cord-329876-4cgrjnjo	94	25	57.59	57.59	CD
cord-329876-4cgrjnjo	94	26	Å	å	NN
cord-329876-4cgrjnjo	94	27	,	,	,
cord-329876-4cgrjnjo	94	28	γ	γ	NN
cord-329876-4cgrjnjo	94	29	=	=	SYM
cord-329876-4cgrjnjo	94	30	120	120	CD
cord-329876-4cgrjnjo	94	31	°	°	NNS
cord-329876-4cgrjnjo	94	32	.	.	.
cord-329876-4cgrjnjo	95	1	Diffraction	diffraction	NN
cord-329876-4cgrjnjo	95	2	data	datum	NNS
cord-329876-4cgrjnjo	95	3	statistics	statistic	NNS
cord-329876-4cgrjnjo	95	4	are	be	VBP
cord-329876-4cgrjnjo	95	5	shown	show	VBN
cord-329876-4cgrjnjo	95	6	in	in	IN
cord-329876-4cgrjnjo	95	7	Table	Table	NNP
cord-329876-4cgrjnjo	95	8	1	1	CD
cord-329876-4cgrjnjo	95	9	.	.	.
cord-329876-4cgrjnjo	96	1	The	the	DT
cord-329876-4cgrjnjo	96	2	structure	structure	NN
cord-329876-4cgrjnjo	96	3	of	of	IN
cord-329876-4cgrjnjo	96	4	the	the	DT
cord-329876-4cgrjnjo	96	5	MERS	MERS	NNP
cord-329876-4cgrjnjo	96	6	-	-	HYPH
cord-329876-4cgrjnjo	96	7	CoV	cov	NN
cord-329876-4cgrjnjo	96	8	PL	pl	NN
cord-329876-4cgrjnjo	96	9	pro	pro	JJ
cord-329876-4cgrjnjo	96	10	(	(	-LRB-
cord-329876-4cgrjnjo	96	11	C111S)-Ub	c111s)-ub	NN
cord-329876-4cgrjnjo	96	12	complex	complex	NN
cord-329876-4cgrjnjo	96	13	was	be	VBD
cord-329876-4cgrjnjo	96	14	solved	solve	VBN
cord-329876-4cgrjnjo	96	15	by	by	IN
cord-329876-4cgrjnjo	96	16	molecular	molecular	JJ
cord-329876-4cgrjnjo	96	17	replacement	replacement	NN
cord-329876-4cgrjnjo	96	18	using	use	VBG
cord-329876-4cgrjnjo	96	19	MOLREP	MOLREP	NNP
cord-329876-4cgrjnjo	96	20	(	(	-LRB-
cord-329876-4cgrjnjo	96	21	Vagin	Vagin	NNP
cord-329876-4cgrjnjo	96	22	&	&	CC
cord-329876-4cgrjnjo	96	23	Teplyakov	Teplyakov	NNP
cord-329876-4cgrjnjo	96	24	,	,	,
cord-329876-4cgrjnjo	96	25	2010	2010	CD
cord-329876-4cgrjnjo	96	26	)	)	-RRB-
cord-329876-4cgrjnjo	96	27	.	.	.
cord-329876-4cgrjnjo	97	1	The	the	DT
cord-329876-4cgrjnjo	97	2	program	program	NN
cord-329876-4cgrjnjo	97	3	selected	select	VBD
cord-329876-4cgrjnjo	97	4	the	the	DT
cord-329876-4cgrjnjo	97	5	MERS	MERS	NNP
cord-329876-4cgrjnjo	97	6	-	-	HYPH
cord-329876-4cgrjnjo	97	7	CoV	cov	NN
cord-329876-4cgrjnjo	97	8	PL	pl	NN
cord-329876-4cgrjnjo	97	9	pro	pro	JJ
cord-329876-4cgrjnjo	97	10	(	(	-LRB-
cord-329876-4cgrjnjo	97	11	Protein	Protein	NNP
cord-329876-4cgrjnjo	97	12	Data	Data	NNP
cord-329876-4cgrjnjo	97	13	Bank	Bank	NNP
cord-329876-4cgrjnjo	97	14	(	(	-LRB-
cord-329876-4cgrjnjo	97	15	PDB	PDB	NNP
cord-329876-4cgrjnjo	97	16	)	)	-RRB-
cord-329876-4cgrjnjo	97	17	entry	entry	NN
cord-329876-4cgrjnjo	97	18	4P16	4p16	CD
cord-329876-4cgrjnjo	97	19	,	,	,
cord-329876-4cgrjnjo	97	20	Lei	Lei	NNP
cord-329876-4cgrjnjo	97	21	et	et	FW
cord-329876-4cgrjnjo	97	22	al	al	NNP
cord-329876-4cgrjnjo	97	23	.	.	.
cord-329876-4cgrjnjo	98	1	,	,	,
cord-329876-4cgrjnjo	98	2	2014	2014	CD
cord-329876-4cgrjnjo	98	3	)	)	-RRB-
cord-329876-4cgrjnjo	98	4	as	as	IN
cord-329876-4cgrjnjo	98	5	the	the	DT
cord-329876-4cgrjnjo	98	6	first	first	JJ
cord-329876-4cgrjnjo	98	7	search	search	NN
cord-329876-4cgrjnjo	98	8	model	model	NN
cord-329876-4cgrjnjo	98	9	.	.	.
cord-329876-4cgrjnjo	99	1	Human	human	JJ
cord-329876-4cgrjnjo	99	2	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	99	3	(	(	-LRB-
cord-329876-4cgrjnjo	99	4	PDB	PDB	NNP
cord-329876-4cgrjnjo	99	5	entry	entry	NN
cord-329876-4cgrjnjo	99	6	:	:	:
cord-329876-4cgrjnjo	99	7	1UBQ	1ubq	CD
cord-329876-4cgrjnjo	99	8	,	,	,
cord-329876-4cgrjnjo	99	9	Vijay-	Vijay-	NNP
cord-329876-4cgrjnjo	99	10	Kumar	Kumar	NNP
cord-329876-4cgrjnjo	99	11	et	et	NNP
cord-329876-4cgrjnjo	99	12	al	al	NNP
cord-329876-4cgrjnjo	99	13	.	.	NNP
cord-329876-4cgrjnjo	99	14	,	,	,
cord-329876-4cgrjnjo	99	15	1987	1987	CD
cord-329876-4cgrjnjo	99	16	)	)	-RRB-
cord-329876-4cgrjnjo	99	17	was	be	VBD
cord-329876-4cgrjnjo	99	18	used	use	VBN
cord-329876-4cgrjnjo	99	19	as	as	IN
cord-329876-4cgrjnjo	99	20	the	the	DT
cord-329876-4cgrjnjo	99	21	second	second	JJ
cord-329876-4cgrjnjo	99	22	search	search	NN
cord-329876-4cgrjnjo	99	23	model	model	NN
cord-329876-4cgrjnjo	99	24	.	.	.
cord-329876-4cgrjnjo	100	1	The	the	DT
cord-329876-4cgrjnjo	100	2	model	model	NN
cord-329876-4cgrjnjo	100	3	of	of	IN
cord-329876-4cgrjnjo	100	4	the	the	DT
cord-329876-4cgrjnjo	100	5	complex	complex	NN
cord-329876-4cgrjnjo	100	6	was	be	VBD
cord-329876-4cgrjnjo	100	7	inspected	inspect	VBN
cord-329876-4cgrjnjo	100	8	and	and	CC
cord-329876-4cgrjnjo	100	9	rebuilt	rebuild	VBN
cord-329876-4cgrjnjo	100	10	using	use	VBG
cord-329876-4cgrjnjo	100	11	Coot	Coot	NNP
cord-329876-4cgrjnjo	100	12	(	(	-LRB-
cord-329876-4cgrjnjo	100	13	Emsley	Emsley	NNP
cord-329876-4cgrjnjo	100	14	et	et	FW
cord-329876-4cgrjnjo	100	15	al	al	NNP
cord-329876-4cgrjnjo	100	16	.	.	NNP
cord-329876-4cgrjnjo	100	17	,	,	,
cord-329876-4cgrjnjo	100	18	2010	2010	CD
cord-329876-4cgrjnjo	100	19	)	)	-RRB-
cord-329876-4cgrjnjo	100	20	,	,	,
cord-329876-4cgrjnjo	100	21	and	and	CC
cord-329876-4cgrjnjo	100	22	refined	refine	VBN
cord-329876-4cgrjnjo	100	23	using	use	VBG
cord-329876-4cgrjnjo	100	24	phenix.refine	phenix.refine	NN
cord-329876-4cgrjnjo	100	25	(	(	-LRB-
cord-329876-4cgrjnjo	100	26	Headd	Headd	NNP
cord-329876-4cgrjnjo	100	27	et	et	NNP
cord-329876-4cgrjnjo	100	28	al	al	NNP
cord-329876-4cgrjnjo	100	29	.	.	NNP
cord-329876-4cgrjnjo	100	30	,	,	,
cord-329876-4cgrjnjo	100	31	2012	2012	CD
cord-329876-4cgrjnjo	100	32	)	)	-RRB-
cord-329876-4cgrjnjo	100	33	.	.	.
cord-329876-4cgrjnjo	101	1	The	the	DT
cord-329876-4cgrjnjo	101	2	refinement	refinement	NN
cord-329876-4cgrjnjo	101	3	statistics	statistic	NNS
cord-329876-4cgrjnjo	101	4	are	be	VBP
cord-329876-4cgrjnjo	101	5	shown	show	VBN
cord-329876-4cgrjnjo	101	6	in	in	IN
cord-329876-4cgrjnjo	101	7	Table	Table	NNP
cord-329876-4cgrjnjo	101	8	1	1	CD
cord-329876-4cgrjnjo	101	9	Kinetic	kinetic	JJ
cord-329876-4cgrjnjo	101	10	assays	assay	NNS
cord-329876-4cgrjnjo	101	11	of	of	IN
cord-329876-4cgrjnjo	101	12	purified	purify	VBN
cord-329876-4cgrjnjo	101	13	PL	pl	NN
cord-329876-4cgrjnjo	101	14	pro	pro	NNP
cord-329876-4cgrjnjo	101	15	s	s	NN
cord-329876-4cgrjnjo	102	1	All	all	DT
cord-329876-4cgrjnjo	102	2	enzymatic	enzymatic	JJ
cord-329876-4cgrjnjo	102	3	assays	assay	NNS
cord-329876-4cgrjnjo	102	4	were	be	VBD
cord-329876-4cgrjnjo	102	5	performed	perform	VBN
cord-329876-4cgrjnjo	102	6	using	use	VBG
cord-329876-4cgrjnjo	102	7	a	a	DT
cord-329876-4cgrjnjo	102	8	96-well	96-well	CD
cord-329876-4cgrjnjo	102	9	microtiter	microtiter	NN
cord-329876-4cgrjnjo	102	10	plate	plate	NN
cord-329876-4cgrjnjo	102	11	and	and	CC
cord-329876-4cgrjnjo	102	12	the	the	DT
cord-329876-4cgrjnjo	102	13	reaction	reaction	NN
cord-329876-4cgrjnjo	102	14	buffer	buffer	NN
cord-329876-4cgrjnjo	102	15	20	20	CD
cord-329876-4cgrjnjo	102	16	mmol	mmol	JJ
cord-329876-4cgrjnjo	102	17	/	/	SYM
cord-329876-4cgrjnjo	102	18	L	L	NNP
cord-329876-4cgrjnjo	102	19	Tris	Tris	NNP
cord-329876-4cgrjnjo	102	20	-	-	HYPH
cord-329876-4cgrjnjo	102	21	HCl	HCl	NNP
cord-329876-4cgrjnjo	102	22	,	,	,
cord-329876-4cgrjnjo	102	23	150	150	CD
cord-329876-4cgrjnjo	102	24	mmol	mmol	JJ
cord-329876-4cgrjnjo	102	25	/	/	SYM
cord-329876-4cgrjnjo	102	26	L	L	NNP
cord-329876-4cgrjnjo	102	27	NaCl	NaCl	NNP
cord-329876-4cgrjnjo	102	28	,	,	,
cord-329876-4cgrjnjo	102	29	pH	pH	NNP
cord-329876-4cgrjnjo	102	30	7.9	7.9	CD
cord-329876-4cgrjnjo	102	31	,	,	,
cord-329876-4cgrjnjo	102	32	2	2	CD
cord-329876-4cgrjnjo	102	33	mmol	mmol	NNP
cord-329876-4cgrjnjo	102	34	/	/	SYM
cord-329876-4cgrjnjo	102	35	L	L	NNP
cord-329876-4cgrjnjo	102	36	dithiothreitol	dithiothreitol	NNP
cord-329876-4cgrjnjo	102	37	(	(	-LRB-
cord-329876-4cgrjnjo	102	38	DTT	DTT	NNP
cord-329876-4cgrjnjo	102	39	)	)	-RRB-
cord-329876-4cgrjnjo	102	40	.	.	.
cord-329876-4cgrjnjo	103	1	The	the	DT
cord-329876-4cgrjnjo	103	2	fluorogenic	fluorogenic	JJ
cord-329876-4cgrjnjo	103	3	substrates	substrate	NNS
cord-329876-4cgrjnjo	103	4	Cbz	Cbz	NNP
cord-329876-4cgrjnjo	103	5	-	-	HYPH
cord-329876-4cgrjnjo	103	6	Arg	Arg	NNP
cord-329876-4cgrjnjo	103	7	-	-	HYPH
cord-329876-4cgrjnjo	103	8	Leu	Leu	NNP
cord-329876-4cgrjnjo	104	1	-Arg	-Arg	:
cord-329876-4cgrjnjo	104	2	-	-	:
cord-329876-4cgrjnjo	104	3	Gly	Gly	NNP
cord-329876-4cgrjnjo	104	4	-	-	HYPH
cord-329876-4cgrjnjo	104	5	Gly-7-amino-4-methylcoumarin	Gly-7-amino-4-methylcoumarin	NNP
cord-329876-4cgrjnjo	105	1	(	(	-LRB-
cord-329876-4cgrjnjo	105	2	Z	z	NN
cord-329876-4cgrjnjo	105	3	-	-	HYPH
cord-329876-4cgrjnjo	105	4	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	105	5	-	-	HYPH
cord-329876-4cgrjnjo	105	6	AMC	AMC	NNP
cord-329876-4cgrjnjo	105	7	)	)	-RRB-
cord-329876-4cgrjnjo	106	1	(	(	-LRB-
cord-329876-4cgrjnjo	106	2	Bachem	Bachem	NNP
cord-329876-4cgrjnjo	106	3	)	)	-RRB-
cord-329876-4cgrjnjo	106	4	,	,	,
cord-329876-4cgrjnjo	106	5	Z	Z	NNP
cord-329876-4cgrjnjo	106	6	-	-	HYPH
cord-329876-4cgrjnjo	106	7	LRGG	LRGG	NNP
cord-329876-4cgrjnjo	106	8	-	-	HYPH
cord-329876-4cgrjnjo	106	9	AMC	AMC	NNP
cord-329876-4cgrjnjo	106	10	(	(	-LRB-
cord-329876-4cgrjnjo	106	11	BostonBiochem	BostonBiochem	NNP
cord-329876-4cgrjnjo	106	12	)	)	-RRB-
cord-329876-4cgrjnjo	106	13	,	,	,
cord-329876-4cgrjnjo	106	14	and	and	CC
cord-329876-4cgrjnjo	106	15	ubiquitin	ubiquitin	JJ
cord-329876-4cgrjnjo	106	16	-	-	HYPH
cord-329876-4cgrjnjo	106	17	AMC	AMC	NNP
cord-329876-4cgrjnjo	106	18	(	(	-LRB-
cord-329876-4cgrjnjo	106	19	Ub	Ub	NNP
cord-329876-4cgrjnjo	106	20	-	-	HYPH
cord-329876-4cgrjnjo	106	21	AMC	AMC	NNP
cord-329876-4cgrjnjo	106	22	)	)	-RRB-
cord-329876-4cgrjnjo	107	1	(	(	-LRB-
cord-329876-4cgrjnjo	107	2	BostonBiochem	BostonBiochem	NNP
cord-329876-4cgrjnjo	107	3	)	)	-RRB-
cord-329876-4cgrjnjo	107	4	were	be	VBD
cord-329876-4cgrjnjo	107	5	used	use	VBN
cord-329876-4cgrjnjo	107	6	.	.	.
cord-329876-4cgrjnjo	108	1	The	the	DT
cord-329876-4cgrjnjo	108	2	fluorescence	fluorescence	NN
cord-329876-4cgrjnjo	108	3	of	of	IN
cord-329876-4cgrjnjo	108	4	free	free	JJ
cord-329876-4cgrjnjo	108	5	AMC	AMC	NNP
cord-329876-4cgrjnjo	108	6	with	with	IN
cord-329876-4cgrjnjo	108	7	different	different	JJ
cord-329876-4cgrjnjo	108	8	concentrations	concentration	NNS
cord-329876-4cgrjnjo	108	9	(	(	-LRB-
cord-329876-4cgrjnjo	108	10	5	5	CD
cord-329876-4cgrjnjo	108	11	nmol	nmol	NNP
cord-329876-4cgrjnjo	108	12	/	/	SYM
cord-329876-4cgrjnjo	108	13	L-2.5	L-2.5	NNP
cord-329876-4cgrjnjo	108	14	μmol	μmol	NNP
cord-329876-4cgrjnjo	108	15	/	/	SYM
cord-329876-4cgrjnjo	108	16	L	L	NNP
cord-329876-4cgrjnjo	108	17	)	)	-RRB-
cord-329876-4cgrjnjo	108	18	in	in	IN
cord-329876-4cgrjnjo	108	19	reaction	reaction	NN
cord-329876-4cgrjnjo	108	20	buffer	buffer	NN
cord-329876-4cgrjnjo	108	21	was	be	VBD
cord-329876-4cgrjnjo	108	22	measured	measure	VBN
cord-329876-4cgrjnjo	108	23	to	to	TO
cord-329876-4cgrjnjo	108	24	generate	generate	VB
cord-329876-4cgrjnjo	108	25	a	a	DT
cord-329876-4cgrjnjo	108	26	calibration	calibration	NN
cord-329876-4cgrjnjo	108	27	curve	curve	NN
cord-329876-4cgrjnjo	108	28	,	,	,
cord-329876-4cgrjnjo	108	29	in	in	IN
cord-329876-4cgrjnjo	108	30	order	order	NN
cord-329876-4cgrjnjo	108	31	to	to	TO
cord-329876-4cgrjnjo	108	32	convert	convert	VB
cord-329876-4cgrjnjo	108	33	the	the	DT
cord-329876-4cgrjnjo	108	34	change	change	NN
cord-329876-4cgrjnjo	108	35	of	of	IN
cord-329876-4cgrjnjo	108	36	fluorescence	fluorescence	NN
cord-329876-4cgrjnjo	108	37	intensity	intensity	NN
cord-329876-4cgrjnjo	108	38	per	per	IN
cord-329876-4cgrjnjo	108	39	unit	unit	NN
cord-329876-4cgrjnjo	108	40	of	of	IN
cord-329876-4cgrjnjo	108	41	time	time	NN
cord-329876-4cgrjnjo	108	42	,	,	,
cord-329876-4cgrjnjo	108	43	Δ(AFU	δ(afu	ADD
cord-329876-4cgrjnjo	108	44	)	)	-RRB-
cord-329876-4cgrjnjo	108	45	/s	/s	NNP
cord-329876-4cgrjnjo	108	46	,	,	,
cord-329876-4cgrjnjo	108	47	into	into	IN
cord-329876-4cgrjnjo	108	48	the	the	DT
cord-329876-4cgrjnjo	108	49	amount	amount	NN
cord-329876-4cgrjnjo	108	50	of	of	IN
cord-329876-4cgrjnjo	108	51	hydrolyzed	hydrolyze	VBN
cord-329876-4cgrjnjo	108	52	substrate	substrate	NN
cord-329876-4cgrjnjo	108	53	in	in	IN
cord-329876-4cgrjnjo	108	54	μmol	μmol	NNP
cord-329876-4cgrjnjo	108	55	/	/	SYM
cord-329876-4cgrjnjo	108	56	L	L	NNP
cord-329876-4cgrjnjo	108	57	/	/	SYM
cord-329876-4cgrjnjo	108	58	s	s	NNP
cord-329876-4cgrjnjo	108	59	.	.	.
cord-329876-4cgrjnjo	109	1	The	the	DT
cord-329876-4cgrjnjo	109	2	enzymatic	enzymatic	JJ
cord-329876-4cgrjnjo	109	3	cleavage	cleavage	NN
cord-329876-4cgrjnjo	109	4	reactions	reaction	NNS
cord-329876-4cgrjnjo	109	5	were	be	VBD
cord-329876-4cgrjnjo	109	6	run	run	VBN
cord-329876-4cgrjnjo	109	7	with	with	IN
cord-329876-4cgrjnjo	109	8	an	an	DT
cord-329876-4cgrjnjo	109	9	Flx800	flx800	NN
cord-329876-4cgrjnjo	109	10	fluorescence	fluorescence	NN
cord-329876-4cgrjnjo	109	11	spectrophotometer	spectrophotometer	NN
cord-329876-4cgrjnjo	109	12	(	(	-LRB-
cord-329876-4cgrjnjo	109	13	BioTek	BioTek	NNP
cord-329876-4cgrjnjo	109	14	)	)	-RRB-
cord-329876-4cgrjnjo	109	15	,	,	,
cord-329876-4cgrjnjo	109	16	to	to	TO
cord-329876-4cgrjnjo	109	17	measure	measure	VB
cord-329876-4cgrjnjo	109	18	the	the	DT
cord-329876-4cgrjnjo	109	19	increased	increase	VBN
cord-329876-4cgrjnjo	109	20	fluorescence	fluorescence	NN
cord-329876-4cgrjnjo	109	21	signal	signal	NN
cord-329876-4cgrjnjo	109	22	(	(	-LRB-
cord-329876-4cgrjnjo	109	23	λ	λ	NN
cord-329876-4cgrjnjo	109	24	ex	ex	NN
cord-329876-4cgrjnjo	109	25	:	:	:
cord-329876-4cgrjnjo	109	26	360	360	CD
cord-329876-4cgrjnjo	109	27	nm	nm	NN
cord-329876-4cgrjnjo	109	28	;	;	:
cord-329876-4cgrjnjo	109	29	λ	λ	NN
cord-329876-4cgrjnjo	109	30	em	-PRON-	NN
cord-329876-4cgrjnjo	109	31	:	:	:
cord-329876-4cgrjnjo	109	32	460	460	CD
cord-329876-4cgrjnjo	109	33	nm	nm	NN
cord-329876-4cgrjnjo	109	34	)	)	-RRB-
cord-329876-4cgrjnjo	109	35	resulting	result	VBG
cord-329876-4cgrjnjo	109	36	from	from	IN
cord-329876-4cgrjnjo	109	37	AMC	AMC	NNP
cord-329876-4cgrjnjo	109	38	release	release	NN
cord-329876-4cgrjnjo	109	39	.	.	.
cord-329876-4cgrjnjo	110	1	Reactions	reaction	NNS
cord-329876-4cgrjnjo	110	2	were	be	VBD
cord-329876-4cgrjnjo	110	3	initiated	initiate	VBN
cord-329876-4cgrjnjo	110	4	by	by	IN
cord-329876-4cgrjnjo	110	5	addition	addition	NN
cord-329876-4cgrjnjo	110	6	of	of	IN
cord-329876-4cgrjnjo	110	7	the	the	DT
cord-329876-4cgrjnjo	110	8	proteases	protease	NNS
cord-329876-4cgrjnjo	110	9	to	to	IN
cord-329876-4cgrjnjo	110	10	the	the	DT
cord-329876-4cgrjnjo	110	11	reaction	reaction	NN
cord-329876-4cgrjnjo	110	12	system	system	NN
cord-329876-4cgrjnjo	110	13	.	.	.
cord-329876-4cgrjnjo	111	1	The	the	DT
cord-329876-4cgrjnjo	111	2	peptide	peptide	NN
cord-329876-4cgrjnjo	111	3	-	-	HYPH
cord-329876-4cgrjnjo	111	4	hydrolysis	hydrolysis	NN
cord-329876-4cgrjnjo	111	5	kinetic	kinetic	JJ
cord-329876-4cgrjnjo	111	6	assays	assay	NNS
cord-329876-4cgrjnjo	111	7	were	be	VBD
cord-329876-4cgrjnjo	111	8	performed	perform	VBN
cord-329876-4cgrjnjo	111	9	with	with	IN
cord-329876-4cgrjnjo	111	10	the	the	DT
cord-329876-4cgrjnjo	111	11	following	follow	VBG
cord-329876-4cgrjnjo	111	12	conditions	condition	NNS
cord-329876-4cgrjnjo	111	13	:	:	:
cord-329876-4cgrjnjo	111	14	1	1	CD
cord-329876-4cgrjnjo	111	15	μmol	μmol	NNP
cord-329876-4cgrjnjo	111	16	/	/	SYM
cord-329876-4cgrjnjo	111	17	L	L	NNP
cord-329876-4cgrjnjo	111	18	MERS	MERS	NNP
cord-329876-4cgrjnjo	111	19	-	-	HYPH
cord-329876-4cgrjnjo	111	20	CoV	CoV	NNP
cord-329876-4cgrjnjo	111	21	PL	pl	NN
cord-329876-4cgrjnjo	111	22	pro	pro	JJ
cord-329876-4cgrjnjo	111	23	variant	variant	NN
cord-329876-4cgrjnjo	111	24	(	(	-LRB-
cord-329876-4cgrjnjo	111	25	D164E	D164E	NNP
cord-329876-4cgrjnjo	111	26	,	,	,
cord-329876-4cgrjnjo	111	27	D164A	D164A	NNPS
cord-329876-4cgrjnjo	111	28	,	,	,
cord-329876-4cgrjnjo	111	29	D165E	D165E	NNP
cord-329876-4cgrjnjo	111	30	,	,	,
cord-329876-4cgrjnjo	111	31	F269Y	F269Y	NNP
cord-329876-4cgrjnjo	111	32	)	)	-RRB-
cord-329876-4cgrjnjo	111	33	,	,	,
cord-329876-4cgrjnjo	111	34	or	or	CC
cord-329876-4cgrjnjo	111	35	10	10	CD
cord-329876-4cgrjnjo	111	36	μmol	μmol	NNP
cord-329876-4cgrjnjo	111	37	/	/	SYM
cord-329876-4cgrjnjo	111	38	L	L	NNP
cord-329876-4cgrjnjo	111	39	D165A	D165A	NNP
cord-329876-4cgrjnjo	111	40	,	,	,
cord-329876-4cgrjnjo	111	41	or	or	CC
cord-329876-4cgrjnjo	111	42	0.1	0.1	CD
cord-329876-4cgrjnjo	111	43	μmol	μmol	NNP
cord-329876-4cgrjnjo	111	44	/	/	SYM
cord-329876-4cgrjnjo	111	45	L	L	NNP
cord-329876-4cgrjnjo	111	46	SARS	SARS	NNP
cord-329876-4cgrjnjo	111	47	-	-	HYPH
cord-329876-4cgrjnjo	111	48	CoV	CoV	NNP
cord-329876-4cgrjnjo	111	49	PL	PL	NNP
cord-329876-4cgrjnjo	111	50	pro	pro	NN
cord-329876-4cgrjnjo	111	51	,	,	,
cord-329876-4cgrjnjo	111	52	with	with	IN
cord-329876-4cgrjnjo	111	53	different	different	JJ
cord-329876-4cgrjnjo	111	54	concentrations	concentration	NNS
cord-329876-4cgrjnjo	111	55	(	(	-LRB-
cord-329876-4cgrjnjo	111	56	10	10	CD
cord-329876-4cgrjnjo	111	57	,	,	,
cord-329876-4cgrjnjo	111	58	20	20	CD
cord-329876-4cgrjnjo	111	59	,	,	,
cord-329876-4cgrjnjo	111	60	40	40	CD
cord-329876-4cgrjnjo	111	61	,	,	,
cord-329876-4cgrjnjo	111	62	80	80	CD
cord-329876-4cgrjnjo	111	63	,	,	,
cord-329876-4cgrjnjo	111	64	100	100	CD
cord-329876-4cgrjnjo	111	65	μmol	μmol	NNP
cord-329876-4cgrjnjo	111	66	/	/	SYM
cord-329876-4cgrjnjo	111	67	L	L	NNP
cord-329876-4cgrjnjo	111	68	)	)	-RRB-
cord-329876-4cgrjnjo	111	69	of	of	IN
cord-329876-4cgrjnjo	111	70	Z	z	NN
cord-329876-4cgrjnjo	111	71	-	-	HYPH
cord-329876-4cgrjnjo	111	72	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	111	73	-	-	HYPH
cord-329876-4cgrjnjo	111	74	AMC	AMC	NNP
cord-329876-4cgrjnjo	111	75	or	or	CC
cord-329876-4cgrjnjo	111	76	Z	Z	NNP
cord-329876-4cgrjnjo	111	77	-	-	HYPH
cord-329876-4cgrjnjo	111	78	LRGG	LRGG	NNP
cord-329876-4cgrjnjo	111	79	-	-	HYPH
cord-329876-4cgrjnjo	111	80	AMC	AMC	NNP
cord-329876-4cgrjnjo	111	81	in	in	IN
cord-329876-4cgrjnjo	111	82	a	a	DT
cord-329876-4cgrjnjo	111	83	final	final	JJ
cord-329876-4cgrjnjo	111	84	volume	volume	NN
cord-329876-4cgrjnjo	111	85	of	of	IN
cord-329876-4cgrjnjo	111	86	100	100	CD
cord-329876-4cgrjnjo	111	87	μL	μL	NNS
cord-329876-4cgrjnjo	111	88	at	at	IN
cord-329876-4cgrjnjo	111	89	25	25	CD
cord-329876-4cgrjnjo	111	90	°	°	NN
cord-329876-4cgrjnjo	111	91	C	c	NN
cord-329876-4cgrjnjo	111	92	.	.	.
cord-329876-4cgrjnjo	112	1	The	the	DT
cord-329876-4cgrjnjo	112	2	kinetic	kinetic	JJ
cord-329876-4cgrjnjo	112	3	curves	curve	NNS
cord-329876-4cgrjnjo	112	4	for	for	IN
cord-329876-4cgrjnjo	112	5	the	the	DT
cord-329876-4cgrjnjo	112	6	proteases	protease	NNS
cord-329876-4cgrjnjo	112	7	and	and	CC
cord-329876-4cgrjnjo	112	8	their	-PRON-	PRP$
cord-329876-4cgrjnjo	112	9	variants	variant	NNS
cord-329876-4cgrjnjo	112	10	with	with	IN
cord-329876-4cgrjnjo	112	11	the	the	DT
cord-329876-4cgrjnjo	112	12	substrates	substrate	NNS
cord-329876-4cgrjnjo	112	13	Z	z	NN
cord-329876-4cgrjnjo	112	14	-	-	HYPH
cord-329876-4cgrjnjo	112	15	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	112	16	-	-	HYPH
cord-329876-4cgrjnjo	112	17	AMC	AMC	NNP
cord-329876-4cgrjnjo	112	18	or	or	CC
cord-329876-4cgrjnjo	112	19	Z	Z	NNP
cord-329876-4cgrjnjo	112	20	-	-	HYPH
cord-329876-4cgrjnjo	112	21	LRGG	LRGG	NNP
cord-329876-4cgrjnjo	112	22	-	-	HYPH
cord-329876-4cgrjnjo	112	23	AMC	AMC	NNP
cord-329876-4cgrjnjo	112	24	were	be	VBD
cord-329876-4cgrjnjo	112	25	linear	linear	JJ
cord-329876-4cgrjnjo	112	26	and	and	CC
cord-329876-4cgrjnjo	112	27	the	the	DT
cord-329876-4cgrjnjo	112	28	initial	initial	JJ
cord-329876-4cgrjnjo	112	29	velocities	velocity	NNS
cord-329876-4cgrjnjo	112	30	also	also	RB
cord-329876-4cgrjnjo	112	31	increased	increase	VBD
cord-329876-4cgrjnjo	112	32	linearly	linearly	RB
cord-329876-4cgrjnjo	112	33	with	with	IN
cord-329876-4cgrjnjo	112	34	substrate	substrate	JJ
cord-329876-4cgrjnjo	112	35	concentration	concentration	NN
cord-329876-4cgrjnjo	112	36	.	.	.
cord-329876-4cgrjnjo	113	1	No	no	DT
cord-329876-4cgrjnjo	113	2	saturation	saturation	NN
cord-329876-4cgrjnjo	113	3	was	be	VBD
cord-329876-4cgrjnjo	113	4	observed	observe	VBN
cord-329876-4cgrjnjo	113	5	.	.	.
cord-329876-4cgrjnjo	114	1	Therefore	therefore	RB
cord-329876-4cgrjnjo	114	2	,	,	,
cord-329876-4cgrjnjo	114	3	the	the	DT
cord-329876-4cgrjnjo	114	4	data	datum	NNS
cord-329876-4cgrjnjo	114	5	were	be	VBD
cord-329876-4cgrjnjo	114	6	fitted	fit	VBN
cord-329876-4cgrjnjo	114	7	to	to	IN
cord-329876-4cgrjnjo	114	8	the	the	DT
cord-329876-4cgrjnjo	114	9	equation	equation	NN
cord-329876-4cgrjnjo	114	10	v/[E	v/[E	NNP
cord-329876-4cgrjnjo	114	11	]	]	-RRB-
cord-329876-4cgrjnjo	114	12	tot	tot	NN
cord-329876-4cgrjnjo	114	13	.	.	.
cord-329876-4cgrjnjo	115	1	=	=	NFP
cord-329876-4cgrjnjo	116	1	k	k	NNP
cord-329876-4cgrjnjo	116	2	app	app	NN
cord-329876-4cgrjnjo	116	3	[	[	-LRB-
cord-329876-4cgrjnjo	116	4	S	S	NNP
cord-329876-4cgrjnjo	116	5	]	]	-RRB-
cord-329876-4cgrjnjo	116	6	,	,	,
cord-329876-4cgrjnjo	116	7	where	where	WRB
cord-329876-4cgrjnjo	116	8	k	k	NNP
cord-329876-4cgrjnjo	116	9	app	app	NN
cord-329876-4cgrjnjo	116	10	approximates	approximate	VBZ
cord-329876-4cgrjnjo	116	11	k	k	XX
cord-329876-4cgrjnjo	116	12	cat	cat	NN
cord-329876-4cgrjnjo	116	13	/K	/K	.
cord-329876-4cgrjnjo	116	14	M	M	NNP
cord-329876-4cgrjnjo	116	15	,	,	,
cord-329876-4cgrjnjo	116	16	as	as	IN
cord-329876-4cgrjnjo	116	17	described	describe	VBN
cord-329876-4cgrjnjo	116	18	previously	previously	RB
cord-329876-4cgrjnjo	116	19	(	(	-LRB-
cord-329876-4cgrjnjo	116	20	Barretto	Barretto	NNP
cord-329876-4cgrjnjo	116	21	et	et	NNP
cord-329876-4cgrjnjo	116	22	al	al	NNP
cord-329876-4cgrjnjo	116	23	.	.	NNP
cord-329876-4cgrjnjo	116	24	,	,	,
cord-329876-4cgrjnjo	116	25	2005	2005	CD
cord-329876-4cgrjnjo	116	26	;	;	:
cord-329876-4cgrjnjo	116	27	Wojdyla	Wojdyla	NNP
cord-329876-4cgrjnjo	116	28	et	et	NNP
cord-329876-4cgrjnjo	116	29	al	al	NNP
cord-329876-4cgrjnjo	116	30	.	.	NNP
cord-329876-4cgrjnjo	116	31	,	,	,
cord-329876-4cgrjnjo	116	32	2010	2010	CD
cord-329876-4cgrjnjo	116	33	)	)	-RRB-
cord-329876-4cgrjnjo	116	34	.	.	.
cord-329876-4cgrjnjo	117	1	The	the	DT
cord-329876-4cgrjnjo	117	2	deubiquitinating	deubiquitinate	VBG
cord-329876-4cgrjnjo	117	3	kinetic	kinetic	JJ
cord-329876-4cgrjnjo	117	4	assays	assay	NNS
cord-329876-4cgrjnjo	117	5	were	be	VBD
cord-329876-4cgrjnjo	117	6	performed	perform	VBN
cord-329876-4cgrjnjo	117	7	under	under	IN
cord-329876-4cgrjnjo	117	8	the	the	DT
cord-329876-4cgrjnjo	117	9	following	follow	VBG
cord-329876-4cgrjnjo	117	10	conditions	condition	NNS
cord-329876-4cgrjnjo	117	11	:	:	:
cord-329876-4cgrjnjo	117	12	0.1	0.1	CD
cord-329876-4cgrjnjo	117	13	μmol	μmol	NNP
cord-329876-4cgrjnjo	117	14	/	/	SYM
cord-329876-4cgrjnjo	117	15	L	L	NNP
cord-329876-4cgrjnjo	117	16	MERS	MERS	NNP
cord-329876-4cgrjnjo	117	17	-	-	HYPH
cord-329876-4cgrjnjo	117	18	CoV	CoV	NNP
cord-329876-4cgrjnjo	117	19	PL	pl	NN
cord-329876-4cgrjnjo	117	20	pro	pro	JJ
cord-329876-4cgrjnjo	117	21	wild	wild	JJ
cord-329876-4cgrjnjo	117	22	-	-	HYPH
cord-329876-4cgrjnjo	117	23	type	type	NN
cord-329876-4cgrjnjo	117	24	or	or	CC
cord-329876-4cgrjnjo	117	25	its	-PRON-	PRP$
cord-329876-4cgrjnjo	117	26	variants	variant	NNS
cord-329876-4cgrjnjo	117	27	D164E	D164E	NNP
cord-329876-4cgrjnjo	117	28	,	,	,
cord-329876-4cgrjnjo	117	29	D164A	D164A	NNPS
cord-329876-4cgrjnjo	117	30	,	,	,
cord-329876-4cgrjnjo	117	31	D165E	D165E	NNP
cord-329876-4cgrjnjo	117	32	,	,	,
cord-329876-4cgrjnjo	117	33	F269Y	F269Y	NNP
cord-329876-4cgrjnjo	117	34	,	,	,
cord-329876-4cgrjnjo	117	35	or	or	CC
cord-329876-4cgrjnjo	117	36	0.5	0.5	CD
cord-329876-4cgrjnjo	117	37	μmol	μmol	NNP
cord-329876-4cgrjnjo	117	38	/	/	SYM
cord-329876-4cgrjnjo	117	39	L	L	NNP
cord-329876-4cgrjnjo	117	40	D165A	D165A	NNP
cord-329876-4cgrjnjo	117	41	,	,	,
cord-329876-4cgrjnjo	117	42	or	or	CC
cord-329876-4cgrjnjo	117	43	0.025	0.025	CD
cord-329876-4cgrjnjo	117	44	μmol	μmol	NNP
cord-329876-4cgrjnjo	117	45	/	/	SYM
cord-329876-4cgrjnjo	117	46	L	L	NNP
cord-329876-4cgrjnjo	117	47	SARS	SARS	NNP
cord-329876-4cgrjnjo	117	48	-	-	HYPH
cord-329876-4cgrjnjo	117	49	CoV	CoV	NNP
cord-329876-4cgrjnjo	117	50	PL	pl	NN
cord-329876-4cgrjnjo	117	51	pro	pro	JJ
cord-329876-4cgrjnjo	117	52	were	be	VBD
cord-329876-4cgrjnjo	117	53	incubated	incubate	VBN
cord-329876-4cgrjnjo	117	54	with	with	IN
cord-329876-4cgrjnjo	117	55	increasing	increase	VBG
cord-329876-4cgrjnjo	117	56	concentrations	concentration	NNS
cord-329876-4cgrjnjo	117	57	(	(	-LRB-
cord-329876-4cgrjnjo	117	58	1	1	CD
cord-329876-4cgrjnjo	117	59	,	,	,
cord-329876-4cgrjnjo	117	60	2	2	CD
cord-329876-4cgrjnjo	117	61	,	,	,
cord-329876-4cgrjnjo	117	62	4	4	CD
cord-329876-4cgrjnjo	117	63	,	,	,
cord-329876-4cgrjnjo	117	64	8	8	CD
cord-329876-4cgrjnjo	117	65	μmol	μmol	NNP
cord-329876-4cgrjnjo	117	66	/	/	SYM
cord-329876-4cgrjnjo	117	67	L	L	NNP
cord-329876-4cgrjnjo	117	68	)	)	-RRB-
cord-329876-4cgrjnjo	117	69	of	of	IN
cord-329876-4cgrjnjo	117	70	Ub	Ub	NNP
cord-329876-4cgrjnjo	117	71	-	-	HYPH
cord-329876-4cgrjnjo	117	72	AMC	AMC	NNP
cord-329876-4cgrjnjo	117	73	in	in	IN
cord-329876-4cgrjnjo	117	74	a	a	DT
cord-329876-4cgrjnjo	117	75	final	final	JJ
cord-329876-4cgrjnjo	117	76	volume	volume	NN
cord-329876-4cgrjnjo	117	77	of	of	IN
cord-329876-4cgrjnjo	117	78	50	50	CD
cord-329876-4cgrjnjo	117	79	μL	μL	NNS
cord-329876-4cgrjnjo	117	80	,	,	,
cord-329876-4cgrjnjo	117	81	at	at	IN
cord-329876-4cgrjnjo	117	82	25	25	CD
cord-329876-4cgrjnjo	117	83	°	°	NN
cord-329876-4cgrjnjo	117	84	C	c	NN
cord-329876-4cgrjnjo	117	85	.	.	.
cord-329876-4cgrjnjo	118	1	Although	although	IN
cord-329876-4cgrjnjo	118	2	PL	PL	NNP
cord-329876-4cgrjnjo	118	3	pro	pro	NNP
cord-329876-4cgrjnjo	118	4	actually	actually	RB
cord-329876-4cgrjnjo	118	5	cleaves	cleave	VBZ
cord-329876-4cgrjnjo	118	6	the	the	DT
cord-329876-4cgrjnjo	118	7	isopeptide	isopeptide	NN
cord-329876-4cgrjnjo	118	8	bond	bond	NN
cord-329876-4cgrjnjo	118	9	between	between	IN
cord-329876-4cgrjnjo	118	10	the	the	DT
cord-329876-4cgrjnjo	118	11	carboxyl	carboxyl	NN
cord-329876-4cgrjnjo	118	12	group	group	NN
cord-329876-4cgrjnjo	118	13	of	of	IN
cord-329876-4cgrjnjo	118	14	the	the	DT
cord-329876-4cgrjnjo	118	15	C	C	NNP
cord-329876-4cgrjnjo	118	16	-	-	HYPH
cord-329876-4cgrjnjo	118	17	terminal	terminal	NN
cord-329876-4cgrjnjo	118	18	Gly	Gly	NNP
cord-329876-4cgrjnjo	118	19	in	in	IN
cord-329876-4cgrjnjo	118	20	Ub	Ub	NNP
cord-329876-4cgrjnjo	118	21	and	and	CC
cord-329876-4cgrjnjo	118	22	the	the	DT
cord-329876-4cgrjnjo	118	23	ε	ε	NNP
cord-329876-4cgrjnjo	118	24	-	-	HYPH
cord-329876-4cgrjnjo	118	25	amino	amino	NNP
cord-329876-4cgrjnjo	118	26	group	group	NN
cord-329876-4cgrjnjo	118	27	of	of	IN
cord-329876-4cgrjnjo	118	28	Lys	Lys	NNP
cord-329876-4cgrjnjo	118	29	in	in	IN
cord-329876-4cgrjnjo	118	30	ubiquitinated	ubiquitinated	JJ
cord-329876-4cgrjnjo	118	31	targets	target	NNS
cord-329876-4cgrjnjo	118	32	in	in	IN
cord-329876-4cgrjnjo	118	33	vivo	vivo	NNP
cord-329876-4cgrjnjo	118	34	,	,	,
cord-329876-4cgrjnjo	118	35	we	-PRON-	PRP
cord-329876-4cgrjnjo	118	36	used	use	VBD
cord-329876-4cgrjnjo	118	37	the	the	DT
cord-329876-4cgrjnjo	118	38	hydrolysis	hydrolysis	NN
cord-329876-4cgrjnjo	118	39	of	of	IN
cord-329876-4cgrjnjo	118	40	Ub	Ub	NNP
cord-329876-4cgrjnjo	118	41	-	-	HYPH
cord-329876-4cgrjnjo	118	42	AMC	AMC	NNP
cord-329876-4cgrjnjo	118	43	here	here	RB
cord-329876-4cgrjnjo	118	44	to	to	TO
cord-329876-4cgrjnjo	118	45	test	test	VB
cord-329876-4cgrjnjo	118	46	the	the	DT
cord-329876-4cgrjnjo	118	47	deubiquitinating	deubiquitinating	NN
cord-329876-4cgrjnjo	118	48	activity	activity	NN
cord-329876-4cgrjnjo	118	49	in	in	IN
cord-329876-4cgrjnjo	118	50	vitro	vitro	FW
cord-329876-4cgrjnjo	118	51	.	.	.
cord-329876-4cgrjnjo	119	1	The	the	DT
cord-329876-4cgrjnjo	119	2	kinetic	kinetic	JJ
cord-329876-4cgrjnjo	119	3	curves	curve	NNS
cord-329876-4cgrjnjo	119	4	of	of	IN
cord-329876-4cgrjnjo	119	5	proteases	protease	NNS
cord-329876-4cgrjnjo	119	6	and	and	CC
cord-329876-4cgrjnjo	119	7	variants	variant	NNS
cord-329876-4cgrjnjo	119	8	with	with	IN
cord-329876-4cgrjnjo	119	9	the	the	DT
cord-329876-4cgrjnjo	119	10	substrate	substrate	JJ
cord-329876-4cgrjnjo	119	11	Ub	Ub	NNP
cord-329876-4cgrjnjo	119	12	-	-	HYPH
cord-329876-4cgrjnjo	119	13	AMC	AMC	NNP
cord-329876-4cgrjnjo	119	14	were	be	VBD
cord-329876-4cgrjnjo	119	15	hyperbolic	hyperbolic	JJ
cord-329876-4cgrjnjo	119	16	and	and	CC
cord-329876-4cgrjnjo	119	17	the	the	DT
cord-329876-4cgrjnjo	119	18	initial	initial	JJ
cord-329876-4cgrjnjo	119	19	velocities	velocity	NNS
cord-329876-4cgrjnjo	119	20	were	be	VBD
cord-329876-4cgrjnjo	119	21	not	not	RB
cord-329876-4cgrjnjo	119	22	linear	linear	JJ
cord-329876-4cgrjnjo	119	23	over	over	IN
cord-329876-4cgrjnjo	119	24	the	the	DT
cord-329876-4cgrjnjo	119	25	concentration	concentration	NN
cord-329876-4cgrjnjo	119	26	of	of	IN
cord-329876-4cgrjnjo	119	27	substrate	substrate	NN
cord-329876-4cgrjnjo	119	28	.	.	.
cord-329876-4cgrjnjo	120	1	However	however	RB
cord-329876-4cgrjnjo	120	2	,	,	,
cord-329876-4cgrjnjo	120	3	saturation	saturation	NN
cord-329876-4cgrjnjo	120	4	was	be	VBD
cord-329876-4cgrjnjo	120	5	still	still	RB
cord-329876-4cgrjnjo	120	6	not	not	RB
cord-329876-4cgrjnjo	120	7	observed	observe	VBN
cord-329876-4cgrjnjo	120	8	within	within	IN
cord-329876-4cgrjnjo	120	9	a	a	DT
cord-329876-4cgrjnjo	120	10	reasonable	reasonable	JJ
cord-329876-4cgrjnjo	120	11	time	time	NN
cord-329876-4cgrjnjo	120	12	.	.	.
cord-329876-4cgrjnjo	121	1	Only	only	RB
cord-329876-4cgrjnjo	121	2	when	when	WRB
cord-329876-4cgrjnjo	121	3	the	the	DT
cord-329876-4cgrjnjo	121	4	ratio	ratio	NN
cord-329876-4cgrjnjo	121	5	of	of	IN
cord-329876-4cgrjnjo	121	6	protein	protein	NN
cord-329876-4cgrjnjo	121	7	to	to	IN
cord-329876-4cgrjnjo	121	8	substrate	substrate	NN
cord-329876-4cgrjnjo	121	9	was	be	VBD
cord-329876-4cgrjnjo	121	10	1:1	1:1	CD
cord-329876-4cgrjnjo	121	11	or	or	CC
cord-329876-4cgrjnjo	121	12	larger	large	JJR
cord-329876-4cgrjnjo	121	13	,	,	,
cord-329876-4cgrjnjo	121	14	were	be	VBD
cord-329876-4cgrjnjo	121	15	we	-PRON-	PRP
cord-329876-4cgrjnjo	121	16	able	able	JJ
cord-329876-4cgrjnjo	121	17	to	to	TO
cord-329876-4cgrjnjo	121	18	achieve	achieve	VB
cord-329876-4cgrjnjo	121	19	saturation	saturation	NN
cord-329876-4cgrjnjo	121	20	within	within	IN
cord-329876-4cgrjnjo	121	21	a	a	DT
cord-329876-4cgrjnjo	121	22	limited	limited	JJ
cord-329876-4cgrjnjo	121	23	time	time	NN
cord-329876-4cgrjnjo	121	24	(	(	-LRB-
cord-329876-4cgrjnjo	121	25	data	datum	NNS
cord-329876-4cgrjnjo	121	26	not	not	RB
cord-329876-4cgrjnjo	121	27	shown	show	VBN
cord-329876-4cgrjnjo	121	28	)	)	-RRB-
cord-329876-4cgrjnjo	121	29	.	.	.
cord-329876-4cgrjnjo	122	1	As	as	IN
cord-329876-4cgrjnjo	122	2	the	the	DT
cord-329876-4cgrjnjo	122	3	initial	initial	JJ
cord-329876-4cgrjnjo	122	4	velocities	velocity	NNS
cord-329876-4cgrjnjo	122	5	did	do	VBD
cord-329876-4cgrjnjo	122	6	not	not	RB
cord-329876-4cgrjnjo	122	7	increase	increase	VB
cord-329876-4cgrjnjo	122	8	in	in	IN
cord-329876-4cgrjnjo	122	9	a	a	DT
cord-329876-4cgrjnjo	122	10	strictly	strictly	RB
cord-329876-4cgrjnjo	122	11	linear	linear	JJ
cord-329876-4cgrjnjo	122	12	fashion	fashion	NN
cord-329876-4cgrjnjo	122	13	with	with	IN
cord-329876-4cgrjnjo	122	14	substrate	substrate	JJ
cord-329876-4cgrjnjo	122	15	concentration	concentration	NN
cord-329876-4cgrjnjo	122	16	,	,	,
cord-329876-4cgrjnjo	122	17	application	application	NN
cord-329876-4cgrjnjo	122	18	of	of	IN
cord-329876-4cgrjnjo	122	19	the	the	DT
cord-329876-4cgrjnjo	122	20	equation	equation	NN
cord-329876-4cgrjnjo	122	21	v/[E	v/[E	NNP
cord-329876-4cgrjnjo	122	22	]	]	-RRB-
cord-329876-4cgrjnjo	122	23	tot	tot	NN
cord-329876-4cgrjnjo	122	24	.	.	.
cord-329876-4cgrjnjo	122	25	=	=	NFP
cord-329876-4cgrjnjo	123	1	k	k	NNP
cord-329876-4cgrjnjo	123	2	app	app	NN
cord-329876-4cgrjnjo	123	3	[	[	-LRB-
cord-329876-4cgrjnjo	123	4	S	S	NNP
cord-329876-4cgrjnjo	123	5	]	]	-RRB-
cord-329876-4cgrjnjo	123	6	to	to	TO
cord-329876-4cgrjnjo	123	7	mimic	mimic	VB
cord-329876-4cgrjnjo	123	8	k	k	NNP
cord-329876-4cgrjnjo	123	9	cat	cat	NN
cord-329876-4cgrjnjo	123	10	/K	/K	.
cord-329876-4cgrjnjo	123	11	M	M	NNP
cord-329876-4cgrjnjo	123	12	would	would	MD
cord-329876-4cgrjnjo	123	13	lead	lead	VB
cord-329876-4cgrjnjo	123	14	to	to	IN
cord-329876-4cgrjnjo	123	15	large	large	JJ
cord-329876-4cgrjnjo	123	16	standard	standard	JJ
cord-329876-4cgrjnjo	123	17	errors	error	NNS
cord-329876-4cgrjnjo	123	18	.	.	.
cord-329876-4cgrjnjo	124	1	We	-PRON-	PRP
cord-329876-4cgrjnjo	124	2	were	be	VBD
cord-329876-4cgrjnjo	124	3	however	however	RB
cord-329876-4cgrjnjo	124	4	able	able	JJ
cord-329876-4cgrjnjo	124	5	to	to	TO
cord-329876-4cgrjnjo	124	6	fit	fit	VB
cord-329876-4cgrjnjo	124	7	the	the	DT
cord-329876-4cgrjnjo	124	8	data	datum	NNS
cord-329876-4cgrjnjo	124	9	to	to	IN
cord-329876-4cgrjnjo	124	10	the	the	DT
cord-329876-4cgrjnjo	124	11	Michaelis	Michaelis	NNP
cord-329876-4cgrjnjo	124	12	-	-	HYPH
cord-329876-4cgrjnjo	124	13	Menten	Menten	NNP
cord-329876-4cgrjnjo	124	14	equation	equation	NN
cord-329876-4cgrjnjo	124	15	using	use	VBG
cord-329876-4cgrjnjo	124	16	the	the	DT
cord-329876-4cgrjnjo	124	17	GraphPad	GraphPad	NNP
cord-329876-4cgrjnjo	124	18	Prism	Prism	NNP
cord-329876-4cgrjnjo	124	19	program	program	NN
cord-329876-4cgrjnjo	124	20	(	(	-LRB-
cord-329876-4cgrjnjo	124	21	GraphPad	GraphPad	NNP
cord-329876-4cgrjnjo	124	22	Software	Software	NNP
cord-329876-4cgrjnjo	124	23	)	)	-RRB-
cord-329876-4cgrjnjo	124	24	,	,	,
cord-329876-4cgrjnjo	124	25	even	even	RB
cord-329876-4cgrjnjo	124	26	though	though	IN
cord-329876-4cgrjnjo	124	27	saturation	saturation	NN
cord-329876-4cgrjnjo	124	28	could	could	MD
cord-329876-4cgrjnjo	124	29	not	not	RB
cord-329876-4cgrjnjo	124	30	be	be	VB
cord-329876-4cgrjnjo	124	31	reached	reach	VBN
cord-329876-4cgrjnjo	125	1	(	(	-LRB-
cord-329876-4cgrjnjo	125	2	Supplemental	Supplemental	NNP
cord-329876-4cgrjnjo	125	3	Figure	Figure	NNP
cord-329876-4cgrjnjo	125	4	1	1	CD
cord-329876-4cgrjnjo	125	5	)	)	-RRB-
cord-329876-4cgrjnjo	125	6	.	.	.
cord-329876-4cgrjnjo	126	1	All	all	DT
cord-329876-4cgrjnjo	126	2	assays	assay	NNS
cord-329876-4cgrjnjo	126	3	were	be	VBD
cord-329876-4cgrjnjo	126	4	performed	perform	VBN
cord-329876-4cgrjnjo	126	5	in	in	IN
cord-329876-4cgrjnjo	126	6	duplicates	duplicate	NNS
cord-329876-4cgrjnjo	126	7	.	.	.
cord-329876-4cgrjnjo	127	1	The	the	DT
cord-329876-4cgrjnjo	127	2	substrate	substrate	NN
cord-329876-4cgrjnjo	127	3	-	-	HYPH
cord-329876-4cgrjnjo	127	4	binding	bind	VBG
cord-329876-4cgrjnjo	127	5	site	site	NN
cord-329876-4cgrjnjo	127	6	of	of	IN
cord-329876-4cgrjnjo	127	7	MERS	MERS	NNP
cord-329876-4cgrjnjo	127	8	-	-	HYPH
cord-329876-4cgrjnjo	127	9	CoV	CoV	NNP
cord-329876-4cgrjnjo	127	10	PL	pl	NN
cord-329876-4cgrjnjo	127	11	pro	pro	JJ
cord-329876-4cgrjnjo	127	12	features	feature	VBZ
cord-329876-4cgrjnjo	127	13	significant	significant	JJ
cord-329876-4cgrjnjo	127	14	differences	difference	NNS
cord-329876-4cgrjnjo	127	15	from	from	IN
cord-329876-4cgrjnjo	127	16	those	those	DT
cord-329876-4cgrjnjo	127	17	of	of	IN
cord-329876-4cgrjnjo	127	18	the	the	DT
cord-329876-4cgrjnjo	127	19	corresponding	correspond	VBG
cord-329876-4cgrjnjo	127	20	SARS	SARS	NNP
cord-329876-4cgrjnjo	127	21	-	-	HYPH
cord-329876-4cgrjnjo	127	22	CoV	CoV	NNP
cord-329876-4cgrjnjo	127	23	enzyme	enzyme	NN
cord-329876-4cgrjnjo	127	24	and	and	CC
cord-329876-4cgrjnjo	127	25	human	human	JJ
cord-329876-4cgrjnjo	127	26	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	127	27	-	-	HYPH
cord-329876-4cgrjnjo	127	28	specific	specific	JJ
cord-329876-4cgrjnjo	127	29	proteases	protease	NNS
cord-329876-4cgrjnjo	127	30	(	(	-LRB-
cord-329876-4cgrjnjo	127	31	USPs	USPs	NNP
cord-329876-4cgrjnjo	127	32	,	,	,
cord-329876-4cgrjnjo	127	33	such	such	JJ
cord-329876-4cgrjnjo	127	34	as	as	IN
cord-329876-4cgrjnjo	127	35	,	,	,
cord-329876-4cgrjnjo	127	36	USP14	usp14	RB
cord-329876-4cgrjnjo	127	37	)	)	-RRB-
cord-329876-4cgrjnjo	128	1	(	(	-LRB-
cord-329876-4cgrjnjo	128	2	Hu	Hu	NNP
cord-329876-4cgrjnjo	128	3	et	et	FW
cord-329876-4cgrjnjo	128	4	al	al	NNP
cord-329876-4cgrjnjo	128	5	.	.	.
cord-329876-4cgrjnjo	129	1	,	,	,
cord-329876-4cgrjnjo	129	2	2005	2005	CD
cord-329876-4cgrjnjo	129	3	;	;	:
cord-329876-4cgrjnjo	129	4	Chou	Chou	NNP
cord-329876-4cgrjnjo	129	5	et	et	NNP
cord-329876-4cgrjnjo	129	6	al	al	NNP
cord-329876-4cgrjnjo	129	7	.	.	NNP
cord-329876-4cgrjnjo	129	8	,	,	,
cord-329876-4cgrjnjo	129	9	2014	2014	CD
cord-329876-4cgrjnjo	129	10	;	;	:
cord-329876-4cgrjnjo	129	11	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	129	12	et	et	NNP
cord-329876-4cgrjnjo	129	13	al	al	NNP
cord-329876-4cgrjnjo	129	14	.	.	NNP
cord-329876-4cgrjnjo	129	15	,	,	,
cord-329876-4cgrjnjo	129	16	2014	2014	CD
cord-329876-4cgrjnjo	129	17	)	)	-RRB-
cord-329876-4cgrjnjo	129	18	.	.	.
cord-329876-4cgrjnjo	130	1	It	-PRON-	PRP
cord-329876-4cgrjnjo	130	2	is	be	VBZ
cord-329876-4cgrjnjo	130	3	therefore	therefore	RB
cord-329876-4cgrjnjo	130	4	of	of	IN
cord-329876-4cgrjnjo	130	5	interest	interest	NN
cord-329876-4cgrjnjo	130	6	to	to	TO
cord-329876-4cgrjnjo	130	7	determine	determine	VB
cord-329876-4cgrjnjo	130	8	the	the	DT
cord-329876-4cgrjnjo	130	9	crystal	crystal	JJ
cord-329876-4cgrjnjo	130	10	structure	structure	NN
cord-329876-4cgrjnjo	130	11	of	of	IN
cord-329876-4cgrjnjo	130	12	the	the	DT
cord-329876-4cgrjnjo	130	13	complex	complex	NN
cord-329876-4cgrjnjo	130	14	between	between	IN
cord-329876-4cgrjnjo	130	15	MERS	MERS	NNP
cord-329876-4cgrjnjo	130	16	-	-	HYPH
cord-329876-4cgrjnjo	130	17	CoV	CoV	NNP
cord-329876-4cgrjnjo	130	18	PL	pl	NN
cord-329876-4cgrjnjo	130	19	pro	pro	NNP
cord-329876-4cgrjnjo	130	20	and	and	CC
cord-329876-4cgrjnjo	130	21	its	-PRON-	PRP$
cord-329876-4cgrjnjo	130	22	substrate	substrate	NN
cord-329876-4cgrjnjo	130	23	,	,	,
cord-329876-4cgrjnjo	130	24	human	human	JJ
cord-329876-4cgrjnjo	130	25	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	130	26	.	.	.
cord-329876-4cgrjnjo	131	1	Hence	hence	RB
cord-329876-4cgrjnjo	131	2	,	,	,
cord-329876-4cgrjnjo	131	3	we	-PRON-	PRP
cord-329876-4cgrjnjo	131	4	crystallized	crystallize	VBD
cord-329876-4cgrjnjo	131	5	the	the	DT
cord-329876-4cgrjnjo	131	6	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	131	7	(	(	-LRB-
cord-329876-4cgrjnjo	131	8	Ub	Ub	NNP
cord-329876-4cgrjnjo	131	9	)	)	-RRB-
cord-329876-4cgrjnjo	131	10	complex	complex	NN
cord-329876-4cgrjnjo	131	11	of	of	IN
cord-329876-4cgrjnjo	131	12	a	a	DT
cord-329876-4cgrjnjo	131	13	MERS	MERS	NNP
cord-329876-4cgrjnjo	131	14	-	-	HYPH
cord-329876-4cgrjnjo	131	15	CoV	cov	NN
cord-329876-4cgrjnjo	131	16	PL	pl	NN
cord-329876-4cgrjnjo	131	17	pro	pro	JJ
cord-329876-4cgrjnjo	131	18	variant	variant	NN
cord-329876-4cgrjnjo	131	19	that	that	WDT
cord-329876-4cgrjnjo	131	20	had	have	VBD
cord-329876-4cgrjnjo	131	21	the	the	DT
cord-329876-4cgrjnjo	131	22	active	active	JJ
cord-329876-4cgrjnjo	131	23	-	-	HYPH
cord-329876-4cgrjnjo	131	24	site	site	NN
cord-329876-4cgrjnjo	131	25	Cys111	cys111	CD
cord-329876-4cgrjnjo	131	26	replaced	replace	VBN
cord-329876-4cgrjnjo	131	27	by	by	IN
cord-329876-4cgrjnjo	131	28	serine	serine	NN
cord-329876-4cgrjnjo	131	29	(	(	-LRB-
cord-329876-4cgrjnjo	131	30	C111S	C111S	NNP
cord-329876-4cgrjnjo	131	31	)	)	-RRB-
cord-329876-4cgrjnjo	131	32	and	and	CC
cord-329876-4cgrjnjo	131	33	determined	determine	VBD
cord-329876-4cgrjnjo	131	34	the	the	DT
cord-329876-4cgrjnjo	131	35	structure	structure	NN
cord-329876-4cgrjnjo	131	36	at	at	IN
cord-329876-4cgrjnjo	131	37	3.16	3.16	CD
cord-329876-4cgrjnjo	131	38	Å	å	NN
cord-329876-4cgrjnjo	131	39	(	(	-LRB-
cord-329876-4cgrjnjo	131	40	Figure	figure	NN
cord-329876-4cgrjnjo	131	41	1A	1a	NN
cord-329876-4cgrjnjo	131	42	)	)	-RRB-
cord-329876-4cgrjnjo	131	43	.	.	.
cord-329876-4cgrjnjo	132	1	There	there	EX
cord-329876-4cgrjnjo	132	2	is	be	VBZ
cord-329876-4cgrjnjo	132	3	one	one	CD
cord-329876-4cgrjnjo	132	4	PL	pl	NN
cord-329876-4cgrjnjo	132	5	pro	pro	JJ
cord-329876-4cgrjnjo	132	6	(	(	-LRB-
cord-329876-4cgrjnjo	132	7	C111S)-Ub	c111s)-ub	NN
cord-329876-4cgrjnjo	132	8	complex	complex	NN
cord-329876-4cgrjnjo	132	9	per	per	IN
cord-329876-4cgrjnjo	132	10	asymmetric	asymmetric	JJ
cord-329876-4cgrjnjo	132	11	unit	unit	NN
cord-329876-4cgrjnjo	132	12	.	.	.
cord-329876-4cgrjnjo	133	1	Using	use	VBG
cord-329876-4cgrjnjo	133	2	the	the	DT
cord-329876-4cgrjnjo	133	3	PDBePISA	pdbepisa	CD
cord-329876-4cgrjnjo	133	4	server	server	NN
cord-329876-4cgrjnjo	133	5	(	(	-LRB-
cord-329876-4cgrjnjo	133	6	Krissinel	Krissinel	NNP
cord-329876-4cgrjnjo	133	7	&	&	CC
cord-329876-4cgrjnjo	133	8	Henrick	Henrick	NNP
cord-329876-4cgrjnjo	133	9	,	,	,
cord-329876-4cgrjnjo	133	10	2007	2007	CD
cord-329876-4cgrjnjo	133	11	)	)	-RRB-
cord-329876-4cgrjnjo	133	12	,	,	,
cord-329876-4cgrjnjo	133	13	the	the	DT
cord-329876-4cgrjnjo	133	14	total	total	JJ
cord-329876-4cgrjnjo	133	15	interface	interface	NN
cord-329876-4cgrjnjo	133	16	region	region	NN
cord-329876-4cgrjnjo	133	17	of	of	IN
cord-329876-4cgrjnjo	133	18	MERS	MERS	NNP
cord-329876-4cgrjnjo	133	19	-	-	HYPH
cord-329876-4cgrjnjo	133	20	CoV	CoV	NNP
cord-329876-4cgrjnjo	133	21	PL	pl	NN
cord-329876-4cgrjnjo	133	22	pro	pro	JJ
cord-329876-4cgrjnjo	133	23	(	(	-LRB-
cord-329876-4cgrjnjo	133	24	C111S)-Ub	c111s)-ub	NN
cord-329876-4cgrjnjo	133	25	was	be	VBD
cord-329876-4cgrjnjo	133	26	determined	determine	VBN
cord-329876-4cgrjnjo	133	27	as	as	IN
cord-329876-4cgrjnjo	133	28	813	813	CD
cord-329876-4cgrjnjo	133	29	Å	å	NN
cord-329876-4cgrjnjo	133	30	2	2	CD
cord-329876-4cgrjnjo	133	31	,	,	,
cord-329876-4cgrjnjo	133	32	close	close	JJ
cord-329876-4cgrjnjo	133	33	to	to	IN
cord-329876-4cgrjnjo	133	34	the	the	DT
cord-329876-4cgrjnjo	133	35	915	915	CD
cord-329876-4cgrjnjo	133	36	Å	å	NN
cord-329876-4cgrjnjo	133	37	2	2	CD
cord-329876-4cgrjnjo	133	38	interface	interface	NN
cord-329876-4cgrjnjo	133	39	of	of	IN
cord-329876-4cgrjnjo	133	40	SARS	SARS	NNP
cord-329876-4cgrjnjo	133	41	-	-	HYPH
cord-329876-4cgrjnjo	133	42	CoV	CoV	NNP
cord-329876-4cgrjnjo	133	43	PL	pl	NN
cord-329876-4cgrjnjo	133	44	pro	pro	NNP
cord-329876-4cgrjnjo	133	45	-Ubal	-Ubal	NNP
cord-329876-4cgrjnjo	133	46	(	(	-LRB-
cord-329876-4cgrjnjo	133	47	ubiquitin	ubiquitin	JJ
cord-329876-4cgrjnjo	133	48	aldehyde	aldehyde	NN
cord-329876-4cgrjnjo	133	49	;	;	:
cord-329876-4cgrjnjo	133	50	PDB	PDB	NNP
cord-329876-4cgrjnjo	133	51	entry	entry	NN
cord-329876-4cgrjnjo	133	52	:	:	:
cord-329876-4cgrjnjo	134	1	4MM3	4mm3	LS
cord-329876-4cgrjnjo	134	2	,	,	,
cord-329876-4cgrjnjo	134	3	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	134	4	et	et	NNP
cord-329876-4cgrjnjo	134	5	al	al	NNP
cord-329876-4cgrjnjo	134	6	.	.	NNP
cord-329876-4cgrjnjo	134	7	,	,	,
cord-329876-4cgrjnjo	134	8	2014	2014	CD
cord-329876-4cgrjnjo	134	9	)	)	-RRB-
cord-329876-4cgrjnjo	134	10	and	and	CC
cord-329876-4cgrjnjo	134	11	the	the	DT
cord-329876-4cgrjnjo	134	12	999	999	CD
cord-329876-4cgrjnjo	134	13	Å	å	NN
cord-329876-4cgrjnjo	134	14	2	2	CD
cord-329876-4cgrjnjo	134	15	of	of	IN
cord-329876-4cgrjnjo	134	16	SARS	SARS	NNP
cord-329876-4cgrjnjo	134	17	-	-	HYPH
cord-329876-4cgrjnjo	134	18	CoV	CoV	NNP
cord-329876-4cgrjnjo	134	19	PL	pl	NN
cord-329876-4cgrjnjo	134	20	pro	pro	JJ
cord-329876-4cgrjnjo	134	21	(	(	-LRB-
cord-329876-4cgrjnjo	134	22	C112S)-Ub	c112s)-ub	JJ
cord-329876-4cgrjnjo	134	23	(	(	-LRB-
cord-329876-4cgrjnjo	134	24	PDB	PDB	NNP
cord-329876-4cgrjnjo	134	25	:	:	:
cord-329876-4cgrjnjo	134	26	4M0W	4m0w	CD
cord-329876-4cgrjnjo	134	27	,	,	,
cord-329876-4cgrjnjo	134	28	Chou	Chou	NNP
cord-329876-4cgrjnjo	134	29	et	et	NNP
cord-329876-4cgrjnjo	134	30	al	al	NNP
cord-329876-4cgrjnjo	134	31	.	.	NNP
cord-329876-4cgrjnjo	134	32	,	,	,
cord-329876-4cgrjnjo	134	33	2014	2014	CD
cord-329876-4cgrjnjo	134	34	)	)	-RRB-
cord-329876-4cgrjnjo	134	35	,	,	,
cord-329876-4cgrjnjo	134	36	but	but	CC
cord-329876-4cgrjnjo	134	37	less	less	JJR
cord-329876-4cgrjnjo	134	38	than	than	IN
cord-329876-4cgrjnjo	135	1	the	the	DT
cord-329876-4cgrjnjo	135	2	1503	1503	CD
cord-329876-4cgrjnjo	135	3	Å	Å	NNP
cord-329876-4cgrjnjo	135	4	2	2	CD
cord-329876-4cgrjnjo	135	5	observed	observe	VBD
cord-329876-4cgrjnjo	135	6	for	for	IN
cord-329876-4cgrjnjo	135	7	USP14-Ubal	usp14-ubal	CD
cord-329876-4cgrjnjo	135	8	(	(	-LRB-
cord-329876-4cgrjnjo	135	9	PDB	PDB	NNP
cord-329876-4cgrjnjo	135	10	:	:	:
cord-329876-4cgrjnjo	135	11	2AYO	2ayo	CD
cord-329876-4cgrjnjo	135	12	,	,	,
cord-329876-4cgrjnjo	135	13	Hu	Hu	NNP
cord-329876-4cgrjnjo	135	14	et	et	NNP
cord-329876-4cgrjnjo	135	15	al	al	NNP
cord-329876-4cgrjnjo	135	16	.	.	NNP
cord-329876-4cgrjnjo	135	17	,	,	,
cord-329876-4cgrjnjo	135	18	2005	2005	CD
cord-329876-4cgrjnjo	135	19	)	)	-RRB-
cord-329876-4cgrjnjo	135	20	.	.	.
cord-329876-4cgrjnjo	136	1	The	the	DT
cord-329876-4cgrjnjo	136	2	overall	overall	JJ
cord-329876-4cgrjnjo	136	3	structure	structure	NN
cord-329876-4cgrjnjo	136	4	of	of	IN
cord-329876-4cgrjnjo	136	5	MERS	MERS	NNP
cord-329876-4cgrjnjo	136	6	-	-	HYPH
cord-329876-4cgrjnjo	136	7	CoV	CoV	NNP
cord-329876-4cgrjnjo	136	8	PL	pl	NN
cord-329876-4cgrjnjo	136	9	pro	pro	JJ
cord-329876-4cgrjnjo	136	10	(	(	-LRB-
cord-329876-4cgrjnjo	136	11	C111S	C111S	NNP
cord-329876-4cgrjnjo	136	12	)	)	-RRB-
cord-329876-4cgrjnjo	136	13	is	be	VBZ
cord-329876-4cgrjnjo	136	14	very	very	RB
cord-329876-4cgrjnjo	136	15	similar	similar	JJ
cord-329876-4cgrjnjo	136	16	to	to	IN
cord-329876-4cgrjnjo	136	17	that	that	DT
cord-329876-4cgrjnjo	136	18	of	of	IN
cord-329876-4cgrjnjo	136	19	the	the	DT
cord-329876-4cgrjnjo	136	20	substrate	substrate	NN
cord-329876-4cgrjnjo	136	21	-	-	HYPH
cord-329876-4cgrjnjo	136	22	free	free	JJ
cord-329876-4cgrjnjo	136	23	PL	pl	NN
cord-329876-4cgrjnjo	136	24	pro	pro	JJ
cord-329876-4cgrjnjo	137	1	(	(	-LRB-
cord-329876-4cgrjnjo	137	2	Lei	Lei	NNP
cord-329876-4cgrjnjo	137	3	et	et	FW
cord-329876-4cgrjnjo	137	4	al	al	NNP
cord-329876-4cgrjnjo	137	5	.	.	NNP
cord-329876-4cgrjnjo	137	6	,	,	,
cord-329876-4cgrjnjo	137	7	2014	2014	CD
cord-329876-4cgrjnjo	137	8	)	)	-RRB-
cord-329876-4cgrjnjo	137	9	,	,	,
cord-329876-4cgrjnjo	137	10	with	with	IN
cord-329876-4cgrjnjo	137	11	a	a	DT
cord-329876-4cgrjnjo	137	12	root	root	NN
cord-329876-4cgrjnjo	137	13	-	-	HYPH
cord-329876-4cgrjnjo	137	14	mean	mean	JJ
cord-329876-4cgrjnjo	137	15	-	-	HYPH
cord-329876-4cgrjnjo	137	16	square	square	NN
cord-329876-4cgrjnjo	137	17	deviation	deviation	NN
cord-329876-4cgrjnjo	137	18	(	(	-LRB-
cord-329876-4cgrjnjo	137	19	RMSD	RMSD	NNP
cord-329876-4cgrjnjo	137	20	)	)	-RRB-
cord-329876-4cgrjnjo	137	21	of	of	IN
cord-329876-4cgrjnjo	137	22	0.91	0.91	CD
cord-329876-4cgrjnjo	137	23	Å	å	NN
cord-329876-4cgrjnjo	137	24	for	for	IN
cord-329876-4cgrjnjo	137	25	corresponding	correspond	VBG
cord-329876-4cgrjnjo	137	26	Cα	Cα	NNP
cord-329876-4cgrjnjo	137	27	atoms	atom	NNS
cord-329876-4cgrjnjo	137	28	between	between	IN
cord-329876-4cgrjnjo	137	29	these	these	DT
cord-329876-4cgrjnjo	137	30	two	two	CD
cord-329876-4cgrjnjo	137	31	structures	structure	NNS
cord-329876-4cgrjnjo	137	32	.	.	.
cord-329876-4cgrjnjo	138	1	Nevertheless	nevertheless	RB
cord-329876-4cgrjnjo	138	2	,	,	,
cord-329876-4cgrjnjo	138	3	two	two	CD
cord-329876-4cgrjnjo	138	4	differences	difference	NNS
cord-329876-4cgrjnjo	138	5	are	be	VBP
cord-329876-4cgrjnjo	138	6	immediately	immediately	RB
cord-329876-4cgrjnjo	138	7	visible	visible	JJ
cord-329876-4cgrjnjo	138	8	:	:	:
cord-329876-4cgrjnjo	138	9	1	1	LS
cord-329876-4cgrjnjo	138	10	)	)	-RRB-
cord-329876-4cgrjnjo	138	11	,	,	,
cord-329876-4cgrjnjo	138	12	the	the	DT
cord-329876-4cgrjnjo	138	13	zinc	zinc	NN
cord-329876-4cgrjnjo	138	14	-	-	HYPH
cord-329876-4cgrjnjo	138	15	finger	finger	NN
cord-329876-4cgrjnjo	138	16	motif	motif	NN
cord-329876-4cgrjnjo	138	17	has	have	VBZ
cord-329876-4cgrjnjo	138	18	moved	move	VBN
cord-329876-4cgrjnjo	138	19	and	and	CC
cord-329876-4cgrjnjo	138	20	closed	close	VBN
cord-329876-4cgrjnjo	138	21	in	in	RB
cord-329876-4cgrjnjo	138	22	onto	onto	IN
cord-329876-4cgrjnjo	138	23	the	the	DT
cord-329876-4cgrjnjo	138	24	Ub	Ub	NNP
cord-329876-4cgrjnjo	138	25	,	,	,
cord-329876-4cgrjnjo	138	26	compared	compare	VBN
cord-329876-4cgrjnjo	138	27	to	to	IN
cord-329876-4cgrjnjo	138	28	the	the	DT
cord-329876-4cgrjnjo	138	29	free	free	JJ
cord-329876-4cgrjnjo	138	30	PL	pl	NN
cord-329876-4cgrjnjo	138	31	pro	pro	NN
cord-329876-4cgrjnjo	138	32	.	.	.
cord-329876-4cgrjnjo	139	1	The	the	DT
cord-329876-4cgrjnjo	139	2	zinc	zinc	NN
cord-329876-4cgrjnjo	139	3	ion	ion	NN
cord-329876-4cgrjnjo	139	4	position	position	NN
cord-329876-4cgrjnjo	139	5	has	have	VBZ
cord-329876-4cgrjnjo	139	6	shifted	shift	VBN
cord-329876-4cgrjnjo	139	7	by	by	IN
cord-329876-4cgrjnjo	139	8	about	about	RB
cord-329876-4cgrjnjo	139	9	4	4	CD
cord-329876-4cgrjnjo	139	10	Å	å	NN
cord-329876-4cgrjnjo	139	11	and	and	CC
cord-329876-4cgrjnjo	139	12	the	the	DT
cord-329876-4cgrjnjo	139	13	largest	large	JJS
cord-329876-4cgrjnjo	139	14	deviation	deviation	NN
cord-329876-4cgrjnjo	139	15	between	between	IN
cord-329876-4cgrjnjo	139	16	the	the	DT
cord-329876-4cgrjnjo	139	17	two	two	CD
cord-329876-4cgrjnjo	139	18	structures	structure	NNS
cord-329876-4cgrjnjo	139	19	is	be	VBZ
cord-329876-4cgrjnjo	139	20	~6	~6	.
cord-329876-4cgrjnjo	139	21	Å	å	NN
cord-329876-4cgrjnjo	139	22	for	for	IN
cord-329876-4cgrjnjo	139	23	Cys228	cys228	CD
cord-329876-4cgrjnjo	139	24	of	of	IN
cord-329876-4cgrjnjo	139	25	the	the	DT
cord-329876-4cgrjnjo	139	26	zinc	zinc	NN
cord-329876-4cgrjnjo	139	27	-	-	HYPH
cord-329876-4cgrjnjo	139	28	finger	finger	NN
cord-329876-4cgrjnjo	139	29	region	region	NN
cord-329876-4cgrjnjo	139	30	(	(	-LRB-
cord-329876-4cgrjnjo	139	31	Figure	figure	NN
cord-329876-4cgrjnjo	139	32	1B	1b	CD
cord-329876-4cgrjnjo	139	33	)	)	-RRB-
cord-329876-4cgrjnjo	139	34	;	;	:
cord-329876-4cgrjnjo	139	35	2	2	LS
cord-329876-4cgrjnjo	139	36	)	)	-RRB-
cord-329876-4cgrjnjo	139	37	the	the	DT
cord-329876-4cgrjnjo	139	38	mobile	mobile	JJ
cord-329876-4cgrjnjo	139	39	loop	loop	NN
cord-329876-4cgrjnjo	139	40	271	271	CD
cord-329876-4cgrjnjo	139	41	GIETAVG	GIETAVG	NNP
cord-329876-4cgrjnjo	139	42	277	277	CD
cord-329876-4cgrjnjo	139	43	,	,	,
cord-329876-4cgrjnjo	139	44	also	also	RB
cord-329876-4cgrjnjo	139	45	named	name	VBN
cord-329876-4cgrjnjo	139	46	"	"	``
cord-329876-4cgrjnjo	139	47	BL2	BL2	NNP
cord-329876-4cgrjnjo	139	48	loop	loop	NN
cord-329876-4cgrjnjo	139	49	"	"	''
cord-329876-4cgrjnjo	139	50	,	,	,
cord-329876-4cgrjnjo	139	51	is	be	VBZ
cord-329876-4cgrjnjo	139	52	defined	define	VBN
cord-329876-4cgrjnjo	139	53	by	by	IN
cord-329876-4cgrjnjo	139	54	clear	clear	JJ
cord-329876-4cgrjnjo	139	55	main	main	JJ
cord-329876-4cgrjnjo	139	56	-	-	HYPH
cord-329876-4cgrjnjo	139	57	chain	chain	NN
cord-329876-4cgrjnjo	139	58	electron	electron	NN
cord-329876-4cgrjnjo	139	59	density	density	NN
cord-329876-4cgrjnjo	139	60	(	(	-LRB-
cord-329876-4cgrjnjo	139	61	Figure	figure	NN
cord-329876-4cgrjnjo	139	62	1C	1c	NN
cord-329876-4cgrjnjo	139	63	)	)	-RRB-
cord-329876-4cgrjnjo	139	64	.	.	.
cord-329876-4cgrjnjo	140	1	This	this	DT
cord-329876-4cgrjnjo	140	2	loop	loop	NN
cord-329876-4cgrjnjo	140	3	is	be	VBZ
cord-329876-4cgrjnjo	140	4	disordered	disorder	VBN
cord-329876-4cgrjnjo	140	5	in	in	IN
cord-329876-4cgrjnjo	140	6	substrate	substrate	NN
cord-329876-4cgrjnjo	140	7	-	-	HYPH
cord-329876-4cgrjnjo	140	8	free	free	JJ
cord-329876-4cgrjnjo	140	9	PL	pl	NN
cord-329876-4cgrjnjo	140	10	pro	pro	JJ
cord-329876-4cgrjnjo	140	11	(	(	-LRB-
cord-329876-4cgrjnjo	140	12	Lei	lei	FW
cord-329876-4cgrjnjo	140	13	et	et	FW
cord-329876-4cgrjnjo	140	14	al	al	NNP
cord-329876-4cgrjnjo	140	15	.	.	NNP
cord-329876-4cgrjnjo	140	16	,	,	,
cord-329876-4cgrjnjo	140	17	2014	2014	CD
cord-329876-4cgrjnjo	140	18	;	;	:
cord-329876-4cgrjnjo	140	19	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	140	20	-	-	HYPH
cord-329876-4cgrjnjo	140	21	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	140	22	et	et	NNP
cord-329876-4cgrjnjo	140	23	al	al	NNP
cord-329876-4cgrjnjo	140	24	.	.	NNP
cord-329876-4cgrjnjo	140	25	,	,	,
cord-329876-4cgrjnjo	140	26	2014	2014	CD
cord-329876-4cgrjnjo	140	27	)	)	-RRB-
cord-329876-4cgrjnjo	140	28	.	.	.
cord-329876-4cgrjnjo	141	1	Compared	compare	VBN
cord-329876-4cgrjnjo	141	2	to	to	IN
cord-329876-4cgrjnjo	141	3	MERS	MERS	NNP
cord-329876-4cgrjnjo	141	4	-	-	HYPH
cord-329876-4cgrjnjo	141	5	CoV	CoV	NNP
cord-329876-4cgrjnjo	141	6	PL	pl	NN
cord-329876-4cgrjnjo	141	7	pro	pro	NNP
cord-329876-4cgrjnjo	141	8	,	,	,
cord-329876-4cgrjnjo	141	9	the	the	DT
cord-329876-4cgrjnjo	141	10	BL2	BL2	NNP
cord-329876-4cgrjnjo	141	11	loop	loop	NN
cord-329876-4cgrjnjo	141	12	267	267	CD
cord-329876-4cgrjnjo	141	13	GNYQCG	GNYQCG	NNP
cord-329876-4cgrjnjo	141	14	272	272	CD
cord-329876-4cgrjnjo	141	15	is	be	VBZ
cord-329876-4cgrjnjo	141	16	shorter	short	JJR
cord-329876-4cgrjnjo	141	17	by	by	IN
cord-329876-4cgrjnjo	141	18	one	one	CD
cord-329876-4cgrjnjo	141	19	residue	residue	NN
cord-329876-4cgrjnjo	141	20	in	in	IN
cord-329876-4cgrjnjo	141	21	SARS	SARS	NNP
cord-329876-4cgrjnjo	141	22	-	-	HYPH
cord-329876-4cgrjnjo	141	23	CoV	CoV	NNP
cord-329876-4cgrjnjo	141	24	PL	pl	NN
cord-329876-4cgrjnjo	141	25	pro	pro	NNP
cord-329876-4cgrjnjo	141	26	.	.	.
cord-329876-4cgrjnjo	142	1	At	at	IN
cord-329876-4cgrjnjo	142	2	the	the	DT
cord-329876-4cgrjnjo	142	3	time	time	NN
cord-329876-4cgrjnjo	142	4	when	when	WRB
cord-329876-4cgrjnjo	142	5	we	-PRON-	PRP
cord-329876-4cgrjnjo	142	6	deposited	deposit	VBD
cord-329876-4cgrjnjo	142	7	in	in	IN
cord-329876-4cgrjnjo	142	8	the	the	DT
cord-329876-4cgrjnjo	142	9	PDB	PDB	NNP
cord-329876-4cgrjnjo	142	10	the	the	DT
cord-329876-4cgrjnjo	142	11	coordinates	coordinate	NNS
cord-329876-4cgrjnjo	142	12	for	for	IN
cord-329876-4cgrjnjo	142	13	the	the	DT
cord-329876-4cgrjnjo	142	14	crystal	crystal	JJ
cord-329876-4cgrjnjo	142	15	structure	structure	NN
cord-329876-4cgrjnjo	142	16	of	of	IN
cord-329876-4cgrjnjo	142	17	the	the	DT
cord-329876-4cgrjnjo	142	18	non	non	JJ
cord-329876-4cgrjnjo	142	19	-	-	JJ
cord-329876-4cgrjnjo	142	20	covalent	covalent	JJ
cord-329876-4cgrjnjo	142	21	complex	complex	JJ
cord-329876-4cgrjnjo	142	22	MERS	MERS	NNP
cord-329876-4cgrjnjo	142	23	-	-	HYPH
cord-329876-4cgrjnjo	142	24	CoV	CoV	NNP
cord-329876-4cgrjnjo	142	25	(	(	-LRB-
cord-329876-4cgrjnjo	142	26	C111S)-Ub	C111S)-Ub	NNP
cord-329876-4cgrjnjo	142	27	(	(	-LRB-
cord-329876-4cgrjnjo	142	28	PDB	PDB	NNP
cord-329876-4cgrjnjo	142	29	:	:	:
cord-329876-4cgrjnjo	142	30	4WUR	4wur	LS
cord-329876-4cgrjnjo	142	31	)	)	-RRB-
cord-329876-4cgrjnjo	142	32	,	,	,
cord-329876-4cgrjnjo	142	33	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	142	34	-	-	HYPH
cord-329876-4cgrjnjo	142	35	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	142	36	et	et	NNP
cord-329876-4cgrjnjo	142	37	al	al	NNP
cord-329876-4cgrjnjo	142	38	.	.	.
cord-329876-4cgrjnjo	143	1	(	(	-LRB-
cord-329876-4cgrjnjo	143	2	2014	2014	CD
cord-329876-4cgrjnjo	143	3	)	)	-RRB-
cord-329876-4cgrjnjo	143	4	described	describe	VBD
cord-329876-4cgrjnjo	143	5	two	two	CD
cord-329876-4cgrjnjo	143	6	crystal	crystal	NN
cord-329876-4cgrjnjo	143	7	structures	structure	NNS
cord-329876-4cgrjnjo	143	8	for	for	IN
cord-329876-4cgrjnjo	143	9	a	a	DT
cord-329876-4cgrjnjo	143	10	covalent	covalent	JJ
cord-329876-4cgrjnjo	143	11	complex	complex	JJ
cord-329876-4cgrjnjo	143	12	MERS	MERS	NNP
cord-329876-4cgrjnjo	143	13	-	-	HYPH
cord-329876-4cgrjnjo	143	14	CoV	cov	NN
cord-329876-4cgrjnjo	143	15	PL	pl	NN
cord-329876-4cgrjnjo	143	16	pro	pro	NNP
cord-329876-4cgrjnjo	143	17	-Ub	-ub	NN
cord-329876-4cgrjnjo	143	18	,	,	,
cord-329876-4cgrjnjo	143	19	in	in	IN
cord-329876-4cgrjnjo	143	20	which	which	WDT
cord-329876-4cgrjnjo	143	21	an	an	DT
cord-329876-4cgrjnjo	143	22	alkyl	alkyl	JJ
cord-329876-4cgrjnjo	143	23	bromide	bromide	NN
cord-329876-4cgrjnjo	143	24	group	group	NN
cord-329876-4cgrjnjo	143	25	introduced	introduce	VBN
cord-329876-4cgrjnjo	143	26	at	at	IN
cord-329876-4cgrjnjo	143	27	the	the	DT
cord-329876-4cgrjnjo	143	28	C	C	NNP
cord-329876-4cgrjnjo	143	29	-	-	HYPH
cord-329876-4cgrjnjo	143	30	terminus	terminus	NN
cord-329876-4cgrjnjo	143	31	of	of	IN
cord-329876-4cgrjnjo	143	32	Ub	Ub	NNP
cord-329876-4cgrjnjo	143	33	had	have	VBD
cord-329876-4cgrjnjo	143	34	formed	form	VBN
cord-329876-4cgrjnjo	143	35	a	a	DT
cord-329876-4cgrjnjo	143	36	thioether	thioether	NN
cord-329876-4cgrjnjo	143	37	with	with	IN
cord-329876-4cgrjnjo	143	38	the	the	DT
cord-329876-4cgrjnjo	143	39	active	active	JJ
cord-329876-4cgrjnjo	143	40	-	-	HYPH
cord-329876-4cgrjnjo	143	41	site	site	NN
cord-329876-4cgrjnjo	143	42	Cys111	cys111	CD
cord-329876-4cgrjnjo	143	43	of	of	IN
cord-329876-4cgrjnjo	143	44	MERS	MERS	NNP
cord-329876-4cgrjnjo	143	45	-	-	HYPH
cord-329876-4cgrjnjo	143	46	CoV	CoV	NNP
cord-329876-4cgrjnjo	143	47	PL	pl	NN
cord-329876-4cgrjnjo	143	48	pro	pro	NNP
cord-329876-4cgrjnjo	143	49	.	.	.
cord-329876-4cgrjnjo	144	1	These	these	DT
cord-329876-4cgrjnjo	144	2	structures	structure	NNS
cord-329876-4cgrjnjo	144	3	were	be	VBD
cord-329876-4cgrjnjo	144	4	in	in	IN
cord-329876-4cgrjnjo	144	5	space	space	NN
cord-329876-4cgrjnjo	144	6	groups	group	NNS
cord-329876-4cgrjnjo	144	7	P6	P6	NNP
cord-329876-4cgrjnjo	144	8	5	5	CD
cord-329876-4cgrjnjo	144	9	22	22	CD
cord-329876-4cgrjnjo	144	10	and	and	CC
cord-329876-4cgrjnjo	144	11	P6	P6	NNP
cord-329876-4cgrjnjo	144	12	3	3	CD
cord-329876-4cgrjnjo	144	13	and	and	CC
cord-329876-4cgrjnjo	144	14	were	be	VBD
cord-329876-4cgrjnjo	144	15	named	name	VBN
cord-329876-4cgrjnjo	144	16	"	"	``
cord-329876-4cgrjnjo	144	17	closed	close	VBN
cord-329876-4cgrjnjo	144	18	"	"	''
cord-329876-4cgrjnjo	144	19	and	and	CC
cord-329876-4cgrjnjo	144	20	"	"	``
cord-329876-4cgrjnjo	144	21	open	open	JJ
cord-329876-4cgrjnjo	144	22	"	"	''
cord-329876-4cgrjnjo	144	23	PL	pl	NN
cord-329876-4cgrjnjo	144	24	pro	pro	JJ
cord-329876-4cgrjnjo	144	25	-Ub	-ub	NN
cord-329876-4cgrjnjo	144	26	complexes	complex	NNS
cord-329876-4cgrjnjo	144	27	(	(	-LRB-
cord-329876-4cgrjnjo	144	28	PDB	PDB	NNP
cord-329876-4cgrjnjo	144	29	:	:	:
cord-329876-4cgrjnjo	145	1	4RF0	4rf0	CD
cord-329876-4cgrjnjo	145	2	and	and	CC
cord-329876-4cgrjnjo	145	3	4RF1	4rf1	CD
cord-329876-4cgrjnjo	145	4	)	)	-RRB-
cord-329876-4cgrjnjo	145	5	,	,	,
cord-329876-4cgrjnjo	145	6	respectively	respectively	RB
cord-329876-4cgrjnjo	145	7	(	(	-LRB-
cord-329876-4cgrjnjo	145	8	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	145	9	-	-	HYPH
cord-329876-4cgrjnjo	145	10	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	145	11	et	et	NNP
cord-329876-4cgrjnjo	145	12	al	al	NNP
cord-329876-4cgrjnjo	145	13	.	.	NNP
cord-329876-4cgrjnjo	145	14	,	,	,
cord-329876-4cgrjnjo	145	15	2014	2014	CD
cord-329876-4cgrjnjo	145	16	)	)	-RRB-
cord-329876-4cgrjnjo	145	17	.	.	.
cord-329876-4cgrjnjo	146	1	Even	even	RB
cord-329876-4cgrjnjo	146	2	though	though	IN
cord-329876-4cgrjnjo	146	3	the	the	DT
cord-329876-4cgrjnjo	146	4	zinc	zinc	NN
cord-329876-4cgrjnjo	146	5	-	-	HYPH
cord-329876-4cgrjnjo	146	6	finger	finger	NN
cord-329876-4cgrjnjo	146	7	motif	motif	NN
cord-329876-4cgrjnjo	146	8	of	of	IN
cord-329876-4cgrjnjo	146	9	PL	pl	NN
cord-329876-4cgrjnjo	146	10	pro	pro	NN
cord-329876-4cgrjnjo	146	11	in	in	IN
cord-329876-4cgrjnjo	146	12	the	the	DT
cord-329876-4cgrjnjo	146	13	former	former	JJ
cord-329876-4cgrjnjo	146	14	complex	complex	NN
cord-329876-4cgrjnjo	146	15	(	(	-LRB-
cord-329876-4cgrjnjo	146	16	space	space	NN
cord-329876-4cgrjnjo	146	17	group	group	NN
cord-329876-4cgrjnjo	146	18	P6	P6	NNP
cord-329876-4cgrjnjo	146	19	5	5	CD
cord-329876-4cgrjnjo	146	20	22	22	CD
cord-329876-4cgrjnjo	146	21	)	)	-RRB-
cord-329876-4cgrjnjo	146	22	is	be	VBZ
cord-329876-4cgrjnjo	146	23	closer	close	JJR
cord-329876-4cgrjnjo	146	24	to	to	IN
cord-329876-4cgrjnjo	146	25	the	the	DT
cord-329876-4cgrjnjo	146	26	Ub	Ub	NNP
cord-329876-4cgrjnjo	146	27	than	than	IN
cord-329876-4cgrjnjo	146	28	in	in	IN
cord-329876-4cgrjnjo	146	29	the	the	DT
cord-329876-4cgrjnjo	146	30	P6	p6	NN
cord-329876-4cgrjnjo	146	31	3	3	CD
cord-329876-4cgrjnjo	146	32	complex	complex	NN
cord-329876-4cgrjnjo	146	33	,	,	,
cord-329876-4cgrjnjo	146	34	both	both	CC
cord-329876-4cgrjnjo	146	35	the	the	DT
cord-329876-4cgrjnjo	146	36	"	"	``
cord-329876-4cgrjnjo	146	37	closed	closed	JJ
cord-329876-4cgrjnjo	146	38	"	"	''
cord-329876-4cgrjnjo	146	39	and	and	CC
cord-329876-4cgrjnjo	146	40	"	"	``
cord-329876-4cgrjnjo	146	41	open	open	JJ
cord-329876-4cgrjnjo	146	42	"	"	''
cord-329876-4cgrjnjo	146	43	complex	complex	JJ
cord-329876-4cgrjnjo	146	44	show	show	NN
cord-329876-4cgrjnjo	146	45	almost	almost	RB
cord-329876-4cgrjnjo	146	46	the	the	DT
cord-329876-4cgrjnjo	146	47	same	same	JJ
cord-329876-4cgrjnjo	146	48	interactions	interaction	NNS
cord-329876-4cgrjnjo	146	49	between	between	IN
cord-329876-4cgrjnjo	146	50	PL	pl	NN
cord-329876-4cgrjnjo	146	51	pro	pro	JJ
cord-329876-4cgrjnjo	146	52	and	and	CC
cord-329876-4cgrjnjo	146	53	Ub	Ub	NNP
cord-329876-4cgrjnjo	146	54	(	(	-LRB-
cord-329876-4cgrjnjo	146	55	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	146	56	-	-	HYPH
cord-329876-4cgrjnjo	146	57	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	146	58	et	et	NNP
cord-329876-4cgrjnjo	146	59	al	al	NNP
cord-329876-4cgrjnjo	146	60	.	.	NNP
cord-329876-4cgrjnjo	146	61	,	,	,
cord-329876-4cgrjnjo	146	62	2014	2014	CD
cord-329876-4cgrjnjo	146	63	)	)	-RRB-
cord-329876-4cgrjnjo	146	64	.	.	.
cord-329876-4cgrjnjo	147	1	The	the	DT
cord-329876-4cgrjnjo	147	2	differences	difference	NNS
cord-329876-4cgrjnjo	147	3	may	may	MD
cord-329876-4cgrjnjo	147	4	be	be	VB
cord-329876-4cgrjnjo	147	5	caused	cause	VBN
cord-329876-4cgrjnjo	147	6	by	by	IN
cord-329876-4cgrjnjo	147	7	crystal	crystal	NN
cord-329876-4cgrjnjo	147	8	packing	packing	NN
cord-329876-4cgrjnjo	147	9	.	.	.
cord-329876-4cgrjnjo	148	1	Our	-PRON-	PRP$
cord-329876-4cgrjnjo	148	2	non	non	JJ
cord-329876-4cgrjnjo	148	3	-	-	JJ
cord-329876-4cgrjnjo	148	4	covalent	covalent	JJ
cord-329876-4cgrjnjo	148	5	complex	complex	NN
cord-329876-4cgrjnjo	148	6	is	be	VBZ
cord-329876-4cgrjnjo	148	7	similar	similar	JJ
cord-329876-4cgrjnjo	148	8	to	to	IN
cord-329876-4cgrjnjo	148	9	the	the	DT
cord-329876-4cgrjnjo	148	10	"	"	``
cord-329876-4cgrjnjo	148	11	open	open	JJ
cord-329876-4cgrjnjo	148	12	"	"	''
cord-329876-4cgrjnjo	148	13	form	form	NN
cord-329876-4cgrjnjo	148	14	of	of	IN
cord-329876-4cgrjnjo	148	15	the	the	DT
cord-329876-4cgrjnjo	148	16	covalent	covalent	JJ
cord-329876-4cgrjnjo	148	17	PL	pl	NN
cord-329876-4cgrjnjo	148	18	pro	pro	JJ
cord-329876-4cgrjnjo	148	19	-Ub	-ub	NN
cord-329876-4cgrjnjo	148	20	complex	complex	JJ
cord-329876-4cgrjnjo	148	21	(	(	-LRB-
cord-329876-4cgrjnjo	148	22	RMSD	RMSD	NNP
cord-329876-4cgrjnjo	148	23	=	=	SYM
cord-329876-4cgrjnjo	148	24	0.58	0.58	CD
cord-329876-4cgrjnjo	148	25	Å	å	NN
cord-329876-4cgrjnjo	148	26	for	for	IN
cord-329876-4cgrjnjo	148	27	the	the	DT
cord-329876-4cgrjnjo	148	28	PL	pl	NN
cord-329876-4cgrjnjo	148	29	pro	pro	NN
cord-329876-4cgrjnjo	148	30	and	and	CC
cord-329876-4cgrjnjo	148	31	0.85	0.85	CD
cord-329876-4cgrjnjo	148	32	Å	å	NN
cord-329876-4cgrjnjo	148	33	for	for	IN
cord-329876-4cgrjnjo	148	34	Ub	Ub	NNP
cord-329876-4cgrjnjo	148	35	,	,	,
cord-329876-4cgrjnjo	148	36	based	base	VBN
cord-329876-4cgrjnjo	148	37	on	on	IN
cord-329876-4cgrjnjo	148	38	all	all	DT
cord-329876-4cgrjnjo	148	39	Cα	Cα	NNP
cord-329876-4cgrjnjo	148	40	atoms	atom	NNS
cord-329876-4cgrjnjo	148	41	)	)	-RRB-
cord-329876-4cgrjnjo	148	42	.	.	.
cord-329876-4cgrjnjo	149	1	All	all	DT
cord-329876-4cgrjnjo	149	2	parts	part	NNS
cord-329876-4cgrjnjo	149	3	of	of	IN
cord-329876-4cgrjnjo	149	4	the	the	DT
cord-329876-4cgrjnjo	149	5	PL	pl	NN
cord-329876-4cgrjnjo	149	6	pro	pro	NN
cord-329876-4cgrjnjo	149	7	except	except	IN
cord-329876-4cgrjnjo	149	8	for	for	IN
cord-329876-4cgrjnjo	149	9	the	the	DT
cord-329876-4cgrjnjo	149	10	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	149	11	-	-	HYPH
cord-329876-4cgrjnjo	149	12	like	like	JJ
cord-329876-4cgrjnjo	149	13	(	(	-LRB-
cord-329876-4cgrjnjo	149	14	Ubl	Ubl	NNP
cord-329876-4cgrjnjo	149	15	)	)	-RRB-
cord-329876-4cgrjnjo	149	16	domain	domain	NN
cord-329876-4cgrjnjo	149	17	interact	interact	VBP
cord-329876-4cgrjnjo	149	18	with	with	IN
cord-329876-4cgrjnjo	149	19	Ub	Ub	NNP
cord-329876-4cgrjnjo	149	20	.	.	.
cord-329876-4cgrjnjo	150	1	Most	Most	JJS
cord-329876-4cgrjnjo	150	2	interactions	interaction	NNS
cord-329876-4cgrjnjo	150	3	in	in	IN
cord-329876-4cgrjnjo	150	4	-	-	HYPH
cord-329876-4cgrjnjo	150	5	volve	volve	NN
cord-329876-4cgrjnjo	150	6	five	five	CD
cord-329876-4cgrjnjo	150	7	surface	surface	NN
cord-329876-4cgrjnjo	150	8	regions	region	NNS
cord-329876-4cgrjnjo	150	9	of	of	IN
cord-329876-4cgrjnjo	150	10	the	the	DT
cord-329876-4cgrjnjo	150	11	PL	pl	NN
cord-329876-4cgrjnjo	150	12	pro	pro	NN
cord-329876-4cgrjnjo	150	13	and	and	CC
cord-329876-4cgrjnjo	150	14	two	two	CD
cord-329876-4cgrjnjo	150	15	regions	region	NNS
cord-329876-4cgrjnjo	150	16	of	of	IN
cord-329876-4cgrjnjo	150	17	Ub	Ub	NNP
cord-329876-4cgrjnjo	150	18	(	(	-LRB-
cord-329876-4cgrjnjo	150	19	Figure	figure	NN
cord-329876-4cgrjnjo	150	20	2A	2a	CD
cord-329876-4cgrjnjo	150	21	)	)	-RRB-
cord-329876-4cgrjnjo	150	22	.	.	.
cord-329876-4cgrjnjo	151	1	These	these	DT
cord-329876-4cgrjnjo	151	2	five	five	CD
cord-329876-4cgrjnjo	151	3	regions	region	NNS
cord-329876-4cgrjnjo	151	4	of	of	IN
cord-329876-4cgrjnjo	151	5	the	the	DT
cord-329876-4cgrjnjo	151	6	PL	pl	NN
cord-329876-4cgrjnjo	151	7	pro	pro	NN
cord-329876-4cgrjnjo	151	8	are	be	VBP
cord-329876-4cgrjnjo	151	9	labelled	label	VBN
cord-329876-4cgrjnjo	151	10	by	by	IN
cord-329876-4cgrjnjo	151	11	Roman	roman	JJ
cord-329876-4cgrjnjo	151	12	numbers	number	NNS
cord-329876-4cgrjnjo	151	13	:	:	:
cord-329876-4cgrjnjo	151	14	I	-PRON-	PRP
cord-329876-4cgrjnjo	151	15	,	,	,
cord-329876-4cgrjnjo	151	16	Leu106-Tyr112	Leu106-Tyr112	NNP
cord-329876-4cgrjnjo	151	17	;	;	:
cord-329876-4cgrjnjo	151	18	II	II	NNP
cord-329876-4cgrjnjo	151	19	,	,	,
cord-329876-4cgrjnjo	151	20	Ala162-Arg168	Ala162-Arg168	NNP
cord-329876-4cgrjnjo	151	21	;	;	:
cord-329876-4cgrjnjo	151	22	III	III	NNP
cord-329876-4cgrjnjo	151	23	,	,	,
cord-329876-4cgrjnjo	151	24	Cys208-Val210	Cys208-Val210	NNP
cord-329876-4cgrjnjo	151	25	;	;	:
cord-329876-4cgrjnjo	151	26	IV	IV	NNP
cord-329876-4cgrjnjo	151	27	,	,	,
cord-329876-4cgrjnjo	151	28	Gly248-Pro250	Gly248-Pro250	NNP
cord-329876-4cgrjnjo	151	29	;	;	:
cord-329876-4cgrjnjo	151	30	V	V	NNP
cord-329876-4cgrjnjo	151	31	,	,	,
cord-329876-4cgrjnjo	151	32	Phe269-Tyr279	Phe269-Tyr279	NNP
cord-329876-4cgrjnjo	151	33	.	.	.
cord-329876-4cgrjnjo	152	1	I	-PRON-	PRP
cord-329876-4cgrjnjo	152	2	and	and	CC
cord-329876-4cgrjnjo	152	3	II	II	NNP
cord-329876-4cgrjnjo	152	4	are	be	VBP
cord-329876-4cgrjnjo	152	5	situated	situate	VBN
cord-329876-4cgrjnjo	152	6	in	in	IN
cord-329876-4cgrjnjo	152	7	the	the	DT
cord-329876-4cgrjnjo	152	8	thumb	thumb	NN
cord-329876-4cgrjnjo	152	9	domain	domain	NN
cord-329876-4cgrjnjo	152	10	;	;	:
cord-329876-4cgrjnjo	152	11	III	III	NNP
cord-329876-4cgrjnjo	152	12	is	be	VBZ
cord-329876-4cgrjnjo	152	13	in	in	IN
cord-329876-4cgrjnjo	152	14	the	the	DT
cord-329876-4cgrjnjo	152	15	fingers	finger	NNS
cord-329876-4cgrjnjo	152	16	domain	domain	NN
cord-329876-4cgrjnjo	152	17	;	;	:
cord-329876-4cgrjnjo	152	18	and	and	CC
cord-329876-4cgrjnjo	152	19	IV	IV	NNP
cord-329876-4cgrjnjo	152	20	and	and	CC
cord-329876-4cgrjnjo	152	21	V	V	NNP
cord-329876-4cgrjnjo	152	22	are	be	VBP
cord-329876-4cgrjnjo	152	23	in	in	IN
cord-329876-4cgrjnjo	152	24	the	the	DT
cord-329876-4cgrjnjo	152	25	palm	palm	NN
cord-329876-4cgrjnjo	152	26	domain	domain	NN
cord-329876-4cgrjnjo	152	27	(	(	-LRB-
cord-329876-4cgrjnjo	152	28	Figures	figure	NNS
cord-329876-4cgrjnjo	152	29	1A	1a	NN
cord-329876-4cgrjnjo	152	30	and	and	CC
cord-329876-4cgrjnjo	152	31	 	 	_SP
cord-329876-4cgrjnjo	152	32	2A	2a	CD
cord-329876-4cgrjnjo	152	33	)	)	-RRB-
cord-329876-4cgrjnjo	152	34	.	.	.
cord-329876-4cgrjnjo	153	1	In	in	IN
cord-329876-4cgrjnjo	153	2	the	the	DT
cord-329876-4cgrjnjo	153	3	following	following	NN
cord-329876-4cgrjnjo	153	4	and	and	CC
cord-329876-4cgrjnjo	153	5	in	in	IN
cord-329876-4cgrjnjo	153	6	the	the	DT
cord-329876-4cgrjnjo	153	7	figure	figure	NN
cord-329876-4cgrjnjo	153	8	labels	label	NNS
cord-329876-4cgrjnjo	153	9	,	,	,
cord-329876-4cgrjnjo	153	10	residues	residue	NNS
cord-329876-4cgrjnjo	153	11	of	of	IN
cord-329876-4cgrjnjo	153	12	Ub	Ub	NNP
cord-329876-4cgrjnjo	153	13	are	be	VBP
cord-329876-4cgrjnjo	153	14	indicated	indicate	VBN
cord-329876-4cgrjnjo	153	15	in	in	IN
cord-329876-4cgrjnjo	153	16	italics	italic	NNS
cord-329876-4cgrjnjo	153	17	to	to	TO
cord-329876-4cgrjnjo	153	18	distinguish	distinguish	VB
cord-329876-4cgrjnjo	153	19	them	-PRON-	PRP
cord-329876-4cgrjnjo	153	20	from	from	IN
cord-329876-4cgrjnjo	153	21	residues	residue	NNS
cord-329876-4cgrjnjo	153	22	of	of	IN
cord-329876-4cgrjnjo	153	23	PL	pl	NN
cord-329876-4cgrjnjo	153	24	pro	pro	NN
cord-329876-4cgrjnjo	153	25	.	.	.
cord-329876-4cgrjnjo	154	1	The	the	DT
cord-329876-4cgrjnjo	154	2	two	two	CD
cord-329876-4cgrjnjo	154	3	interacting	interact	VBG
cord-329876-4cgrjnjo	154	4	regions	region	NNS
cord-329876-4cgrjnjo	154	5	of	of	IN
cord-329876-4cgrjnjo	154	6	Ub	Ub	NNP
cord-329876-4cgrjnjo	154	7	are	be	VBP
cord-329876-4cgrjnjo	154	8	:	:	:
cord-329876-4cgrjnjo	154	9	A	a	LS
cord-329876-4cgrjnjo	154	10	,	,	,
cord-329876-4cgrjnjo	154	11	Arg42-Gln49	arg42-gln49	NN
cord-329876-4cgrjnjo	154	12	;	;	.
cord-329876-4cgrjnjo	155	1	B	b	NN
cord-329876-4cgrjnjo	155	2	,	,	,
cord-329876-4cgrjnjo	155	3	Arg72-Gly76	arg72-gly76	FW
cord-329876-4cgrjnjo	155	4	(	(	-LRB-
cord-329876-4cgrjnjo	155	5	Figure	figure	NN
cord-329876-4cgrjnjo	155	6	2A	2a	CD
cord-329876-4cgrjnjo	155	7	)	)	-RRB-
cord-329876-4cgrjnjo	155	8	.	.	.
cord-329876-4cgrjnjo	156	1	Region	region	NN
cord-329876-4cgrjnjo	156	2	A	a	NN
cord-329876-4cgrjnjo	156	3	of	of	IN
cord-329876-4cgrjnjo	156	4	Ub	Ub	NNP
cord-329876-4cgrjnjo	156	5	consists	consist	NNS
cord-329876-4cgrjnjo	156	6	of	of	IN
cord-329876-4cgrjnjo	156	7	β3	β3	NNP
cord-329876-4cgrjnjo	156	8	,	,	,
cord-329876-4cgrjnjo	156	9	β4	β4	NNP
cord-329876-4cgrjnjo	156	10	,	,	,
cord-329876-4cgrjnjo	156	11	and	and	CC
cord-329876-4cgrjnjo	156	12	the	the	DT
cord-329876-4cgrjnjo	156	13	loop	loop	NN
cord-329876-4cgrjnjo	156	14	between	between	IN
cord-329876-4cgrjnjo	156	15	β3	β3	NN
cord-329876-4cgrjnjo	156	16	and	and	CC
cord-329876-4cgrjnjo	156	17	Structure	Structure	NNP
cord-329876-4cgrjnjo	156	18	of	of	IN
cord-329876-4cgrjnjo	156	19	MERS	MERS	NNP
cord-329876-4cgrjnjo	156	20	-	-	HYPH
cord-329876-4cgrjnjo	156	21	CoV	CoV	NNP
cord-329876-4cgrjnjo	156	22	PL	pl	NN
cord-329876-4cgrjnjo	156	23	pro	pro	JJ
cord-329876-4cgrjnjo	156	24	-ubiquitin	-ubiquitin	JJ
cord-329876-4cgrjnjo	156	25	complex	complex	JJ
cord-329876-4cgrjnjo	156	26	β4	β4	XX
cord-329876-4cgrjnjo	156	27	(	(	-LRB-
cord-329876-4cgrjnjo	156	28	Figure	figure	NN
cord-329876-4cgrjnjo	156	29	2B	2b	CD
cord-329876-4cgrjnjo	156	30	)	)	-RRB-
cord-329876-4cgrjnjo	156	31	.	.	.
cord-329876-4cgrjnjo	157	1	Regions	Regions	NNPS
cord-329876-4cgrjnjo	157	2	II	II	NNP
cord-329876-4cgrjnjo	157	3	and	and	CC
cord-329876-4cgrjnjo	157	4	III	III	NNP
cord-329876-4cgrjnjo	157	5	of	of	IN
cord-329876-4cgrjnjo	157	6	PL	PL	NNP
cord-329876-4cgrjnjo	157	7	pro	pro	JJ
cord-329876-4cgrjnjo	157	8	interact	interact	NN
cord-329876-4cgrjnjo	157	9	with	with	IN
cord-329876-4cgrjnjo	157	10	region	region	NN
cord-329876-4cgrjnjo	157	11	A	a	NN
cord-329876-4cgrjnjo	157	12	of	of	IN
cord-329876-4cgrjnjo	157	13	Ub	Ub	NNP
cord-329876-4cgrjnjo	157	14	.	.	.
cord-329876-4cgrjnjo	158	1	Region	region	NN
cord-329876-4cgrjnjo	158	2	B	B	NNP
cord-329876-4cgrjnjo	158	3	comprises	comprise	VBZ
cord-329876-4cgrjnjo	158	4	the	the	DT
cord-329876-4cgrjnjo	158	5	five	five	CD
cord-329876-4cgrjnjo	158	6	C	c	NN
cord-329876-4cgrjnjo	158	7	-	-	HYPH
cord-329876-4cgrjnjo	158	8	terminal	terminal	NN
cord-329876-4cgrjnjo	158	9	residues	residue	NNS
cord-329876-4cgrjnjo	158	10	,	,	,
cord-329876-4cgrjnjo	158	11	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	158	12	,	,	,
cord-329876-4cgrjnjo	158	13	and	and	CC
cord-329876-4cgrjnjo	158	14	is	be	VBZ
cord-329876-4cgrjnjo	158	15	in	in	IN
cord-329876-4cgrjnjo	158	16	contact	contact	NN
cord-329876-4cgrjnjo	158	17	with	with	IN
cord-329876-4cgrjnjo	158	18	regions	region	NNS
cord-329876-4cgrjnjo	158	19	I	-PRON-	PRP
cord-329876-4cgrjnjo	158	20	,	,	,
cord-329876-4cgrjnjo	158	21	II	II	NNP
cord-329876-4cgrjnjo	158	22	,	,	,
cord-329876-4cgrjnjo	158	23	IV	IV	NNP
cord-329876-4cgrjnjo	158	24	,	,	,
cord-329876-4cgrjnjo	158	25	and	and	CC
cord-329876-4cgrjnjo	158	26	V	v	NN
cord-329876-4cgrjnjo	158	27	of	of	IN
cord-329876-4cgrjnjo	158	28	PL	pl	NN
cord-329876-4cgrjnjo	158	29	pro	pro	FW
cord-329876-4cgrjnjo	158	30	(	(	-LRB-
cord-329876-4cgrjnjo	158	31	Figure	figure	NN
cord-329876-4cgrjnjo	158	32	2C	2c	NN
cord-329876-4cgrjnjo	158	33	)	)	-RRB-
cord-329876-4cgrjnjo	158	34	.	.	.
cord-329876-4cgrjnjo	159	1	The	the	DT
cord-329876-4cgrjnjo	159	2	C	c	NN
cord-329876-4cgrjnjo	159	3	-	-	HYPH
cord-329876-4cgrjnjo	159	4	terminal	terminal	NN
cord-329876-4cgrjnjo	159	5	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	159	6	motif	motif	NN
cord-329876-4cgrjnjo	159	7	contributes	contribute	VBZ
cord-329876-4cgrjnjo	159	8	the	the	DT
cord-329876-4cgrjnjo	159	9	majority	majority	NN
cord-329876-4cgrjnjo	159	10	of	of	IN
cord-329876-4cgrjnjo	159	11	the	the	DT
cord-329876-4cgrjnjo	159	12	interactions	interaction	NNS
cord-329876-4cgrjnjo	159	13	with	with	IN
cord-329876-4cgrjnjo	159	14	the	the	DT
cord-329876-4cgrjnjo	159	15	PL	pl	NN
cord-329876-4cgrjnjo	159	16	pro	pro	NN
cord-329876-4cgrjnjo	159	17	;	;	:
cord-329876-4cgrjnjo	159	18	the	the	DT
cord-329876-4cgrjnjo	159	19	buried	bury	VBN
cord-329876-4cgrjnjo	159	20	surface	surface	NN
cord-329876-4cgrjnjo	159	21	between	between	IN
cord-329876-4cgrjnjo	159	22	Ub	Ub	NNP
cord-329876-4cgrjnjo	159	23	region	region	NN
cord-329876-4cgrjnjo	159	24	B	b	NN
cord-329876-4cgrjnjo	159	25	and	and	CC
cord-329876-4cgrjnjo	159	26	PL	PL	NNP
cord-329876-4cgrjnjo	159	27	pro	pro	NNP
cord-329876-4cgrjnjo	159	28	is	be	VBZ
cord-329876-4cgrjnjo	159	29	477	477	CD
cord-329876-4cgrjnjo	159	30	Å	å	NN
cord-329876-4cgrjnjo	159	31	2	2	CD
cord-329876-4cgrjnjo	159	32	(	(	-LRB-
cord-329876-4cgrjnjo	159	33	out	out	IN
cord-329876-4cgrjnjo	159	34	of	of	IN
cord-329876-4cgrjnjo	159	35	a	a	DT
cord-329876-4cgrjnjo	159	36	total	total	NN
cord-329876-4cgrjnjo	159	37	of	of	IN
cord-329876-4cgrjnjo	159	38	813	813	CD
cord-329876-4cgrjnjo	159	39	Å	å	NN
cord-329876-4cgrjnjo	159	40	2	2	CD
cord-329876-4cgrjnjo	159	41	)	)	-RRB-
cord-329876-4cgrjnjo	159	42	.	.	.
cord-329876-4cgrjnjo	160	1	In	in	IN
cord-329876-4cgrjnjo	160	2	order	order	NN
cord-329876-4cgrjnjo	160	3	to	to	TO
cord-329876-4cgrjnjo	160	4	make	make	VB
cord-329876-4cgrjnjo	160	5	these	these	DT
cord-329876-4cgrjnjo	160	6	interactions	interaction	NNS
cord-329876-4cgrjnjo	160	7	clear	clear	JJ
cord-329876-4cgrjnjo	160	8	,	,	,
cord-329876-4cgrjnjo	160	9	we	-PRON-	PRP
cord-329876-4cgrjnjo	160	10	describe	describe	VBP
cord-329876-4cgrjnjo	160	11	here	here	RB
cord-329876-4cgrjnjo	160	12	in	in	IN
cord-329876-4cgrjnjo	160	13	some	some	DT
cord-329876-4cgrjnjo	160	14	detail	detail	NN
cord-329876-4cgrjnjo	160	15	the	the	DT
cord-329876-4cgrjnjo	160	16	contacts	contact	NNS
cord-329876-4cgrjnjo	160	17	between	between	IN
cord-329876-4cgrjnjo	160	18	the	the	DT
cord-329876-4cgrjnjo	160	19	PL	pl	NN
cord-329876-4cgrjnjo	160	20	pro	pro	NN
cord-329876-4cgrjnjo	160	21	and	and	CC
cord-329876-4cgrjnjo	160	22	regions	region	NNS
cord-329876-4cgrjnjo	160	23	A	a	VBP
cord-329876-4cgrjnjo	160	24	and	and	CC
cord-329876-4cgrjnjo	160	25	B	B	NNP
cord-329876-4cgrjnjo	160	26	of	of	IN
cord-329876-4cgrjnjo	160	27	Ub	Ub	NNP
cord-329876-4cgrjnjo	160	28	.	.	.
cord-329876-4cgrjnjo	161	1	Region	region	NN
cord-329876-4cgrjnjo	161	2	A	a	DT
cord-329876-4cgrjnjo	161	3	(	(	-LRB-
cord-329876-4cgrjnjo	161	4	Arg42-Gln49	arg42-gln49	UH
cord-329876-4cgrjnjo	161	5	)	)	-RRB-
cord-329876-4cgrjnjo	161	6	of	of	IN
cord-329876-4cgrjnjo	161	7	Ub	Ub	NNP
cord-329876-4cgrjnjo	161	8	inserts	insert	NNS
cord-329876-4cgrjnjo	161	9	into	into	IN
cord-329876-4cgrjnjo	161	10	the	the	DT
cord-329876-4cgrjnjo	161	11	space	space	NN
cord-329876-4cgrjnjo	161	12	between	between	IN
cord-329876-4cgrjnjo	161	13	the	the	DT
cord-329876-4cgrjnjo	161	14	thumb	thumb	NN
cord-329876-4cgrjnjo	161	15	and	and	CC
cord-329876-4cgrjnjo	161	16	fingers	finger	NNS
cord-329876-4cgrjnjo	161	17	domains	domain	NNS
cord-329876-4cgrjnjo	161	18	of	of	IN
cord-329876-4cgrjnjo	161	19	PL	pl	NN
cord-329876-4cgrjnjo	161	20	pro	pro	JJ
cord-329876-4cgrjnjo	161	21	(	(	-LRB-
cord-329876-4cgrjnjo	161	22	Figures	figure	NNS
cord-329876-4cgrjnjo	161	23	2A	2a	CD
cord-329876-4cgrjnjo	161	24	-	-	HYPH
cord-329876-4cgrjnjo	161	25	B	b	NN
cord-329876-4cgrjnjo	161	26	)	)	-RRB-
cord-329876-4cgrjnjo	161	27	.	.	.
cord-329876-4cgrjnjo	162	1	Residues	Residues	NNP
cord-329876-4cgrjnjo	162	2	Ile44	Ile44	NNP
cord-329876-4cgrjnjo	162	3	,	,	,
cord-329876-4cgrjnjo	162	4	Ala46	Ala46	NNP
cord-329876-4cgrjnjo	162	5	,	,	,
cord-329876-4cgrjnjo	162	6	and	and	CC
cord-329876-4cgrjnjo	162	7	Gly47	Gly47	NNP
cord-329876-4cgrjnjo	162	8	engage	engage	VB
cord-329876-4cgrjnjo	162	9	in	in	IN
cord-329876-4cgrjnjo	162	10	hydrophobic	hydrophobic	JJ
cord-329876-4cgrjnjo	162	11	interactions	interaction	NNS
cord-329876-4cgrjnjo	162	12	with	with	IN
cord-329876-4cgrjnjo	162	13	Tyr209	tyr209	CD
cord-329876-4cgrjnjo	162	14	and	and	CC
cord-329876-4cgrjnjo	162	15	Val210	Val210	NNP
cord-329876-4cgrjnjo	162	16	of	of	IN
cord-329876-4cgrjnjo	162	17	region	region	NN
cord-329876-4cgrjnjo	162	18	III	III	NNP
cord-329876-4cgrjnjo	162	19	of	of	IN
cord-329876-4cgrjnjo	162	20	PL	pl	NN
cord-329876-4cgrjnjo	162	21	pro	pro	FW
cord-329876-4cgrjnjo	162	22	(	(	-LRB-
cord-329876-4cgrjnjo	162	23	Figure	figure	NN
cord-329876-4cgrjnjo	162	24	2B	2b	CD
cord-329876-4cgrjnjo	162	25	)	)	-RRB-
cord-329876-4cgrjnjo	162	26	.	.	.
cord-329876-4cgrjnjo	163	1	The	the	DT
cord-329876-4cgrjnjo	163	2	hydrophobic	hydrophobic	JJ
cord-329876-4cgrjnjo	163	3	patch	patch	NN
cord-329876-4cgrjnjo	163	4	(	(	-LRB-
cord-329876-4cgrjnjo	163	5	Ile44	Ile44	NNP
cord-329876-4cgrjnjo	163	6	,	,	,
cord-329876-4cgrjnjo	163	7	Ala46	Ala46	NNP
cord-329876-4cgrjnjo	163	8	,	,	,
cord-329876-4cgrjnjo	163	9	and	and	CC
cord-329876-4cgrjnjo	163	10	Gly47	Gly47	NNP
cord-329876-4cgrjnjo	163	11	)	)	-RRB-
cord-329876-4cgrjnjo	163	12	is	be	VBZ
cord-329876-4cgrjnjo	163	13	a	a	DT
cord-329876-4cgrjnjo	163	14	common	common	JJ
cord-329876-4cgrjnjo	163	15	interaction	interaction	NN
cord-329876-4cgrjnjo	163	16	region	region	NN
cord-329876-4cgrjnjo	163	17	utilized	utilize	VBN
cord-329876-4cgrjnjo	163	18	by	by	IN
cord-329876-4cgrjnjo	163	19	Ub	Ub	NNP
cord-329876-4cgrjnjo	163	20	-	-	HYPH
cord-329876-4cgrjnjo	163	21	binding	bind	VBG
cord-329876-4cgrjnjo	163	22	proteins	protein	NNS
cord-329876-4cgrjnjo	163	23	(	(	-LRB-
cord-329876-4cgrjnjo	163	24	Dikic	Dikic	NNP
cord-329876-4cgrjnjo	163	25	et	et	FW
cord-329876-4cgrjnjo	163	26	al	al	NNP
cord-329876-4cgrjnjo	163	27	.	.	NNP
cord-329876-4cgrjnjo	163	28	,	,	,
cord-329876-4cgrjnjo	163	29	2009	2009	CD
cord-329876-4cgrjnjo	163	30	)	)	-RRB-
cord-329876-4cgrjnjo	163	31	.	.	.
cord-329876-4cgrjnjo	164	1	In	in	IN
cord-329876-4cgrjnjo	164	2	particular	particular	JJ
cord-329876-4cgrjnjo	164	3	,	,	,
cord-329876-4cgrjnjo	164	4	the	the	DT
cord-329876-4cgrjnjo	164	5	interaction	interaction	NN
cord-329876-4cgrjnjo	164	6	of	of	IN
cord-329876-4cgrjnjo	164	7	Ile44	Ile44	NNP
cord-329876-4cgrjnjo	164	8	with	with	IN
cord-329876-4cgrjnjo	164	9	Val210	Val210	NNP
cord-329876-4cgrjnjo	164	10	of	of	IN
cord-329876-4cgrjnjo	164	11	PL	PL	NNP
cord-329876-4cgrjnjo	164	12	pro	pro	NNP
cord-329876-4cgrjnjo	164	13	is	be	VBZ
cord-329876-4cgrjnjo	164	14	important	important	JJ
cord-329876-4cgrjnjo	164	15	for	for	IN
cord-329876-4cgrjnjo	164	16	the	the	DT
cord-329876-4cgrjnjo	164	17	deubiquitinase	deubiquitinase	NN
cord-329876-4cgrjnjo	164	18	(	(	-LRB-
cord-329876-4cgrjnjo	164	19	DUB	dub	NN
cord-329876-4cgrjnjo	164	20	)	)	-RRB-
cord-329876-4cgrjnjo	164	21	but	but	CC
cord-329876-4cgrjnjo	164	22	not	not	RB
cord-329876-4cgrjnjo	164	23	for	for	IN
cord-329876-4cgrjnjo	164	24	the	the	DT
cord-329876-4cgrjnjo	164	25	protease	protease	NN
cord-329876-4cgrjnjo	164	26	activity	activity	NN
cord-329876-4cgrjnjo	164	27	.	.	.
cord-329876-4cgrjnjo	165	1	The	the	DT
cord-329876-4cgrjnjo	165	2	variant	variant	NN
cord-329876-4cgrjnjo	165	3	V210R	v210r	NN
cord-329876-4cgrjnjo	165	4	shows	show	VBZ
cord-329876-4cgrjnjo	165	5	dramatically	dramatically	RB
cord-329876-4cgrjnjo	165	6	reduced	reduce	VBN
cord-329876-4cgrjnjo	165	7	DUB	dub	NN
cord-329876-4cgrjnjo	165	8	activity	activity	NN
cord-329876-4cgrjnjo	165	9	,	,	,
cord-329876-4cgrjnjo	165	10	as	as	IN
cord-329876-4cgrjnjo	165	11	demonstrated	demonstrate	VBN
cord-329876-4cgrjnjo	165	12	by	by	IN
cord-329876-4cgrjnjo	165	13	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	165	14	-	-	HYPH
cord-329876-4cgrjnjo	165	15	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	165	16	et	et	NNP
cord-329876-4cgrjnjo	165	17	al	al	NNP
cord-329876-4cgrjnjo	165	18	.	.	.
cord-329876-4cgrjnjo	166	1	(	(	-LRB-
cord-329876-4cgrjnjo	166	2	2014	2014	CD
cord-329876-4cgrjnjo	166	3	)	)	-RRB-
cord-329876-4cgrjnjo	167	1	(	(	-LRB-
cord-329876-4cgrjnjo	167	2	according	accord	VBG
cord-329876-4cgrjnjo	167	3	to	to	IN
cord-329876-4cgrjnjo	167	4	the	the	DT
cord-329876-4cgrjnjo	167	5	numbering	number	VBG
cord-329876-4cgrjnjo	167	6	scheme	scheme	NN
cord-329876-4cgrjnjo	167	7	of	of	IN
cord-329876-4cgrjnjo	167	8	these	these	DT
cord-329876-4cgrjnjo	167	9	authors	author	NNS
cord-329876-4cgrjnjo	167	10	,	,	,
cord-329876-4cgrjnjo	167	11	V210	V210	NNP
cord-329876-4cgrjnjo	167	12	is	be	VBZ
cord-329876-4cgrjnjo	167	13	V1691	v1691	NN
cord-329876-4cgrjnjo	167	14	)	)	-RRB-
cord-329876-4cgrjnjo	167	15	.	.	.
cord-329876-4cgrjnjo	168	1	A	a	DT
cord-329876-4cgrjnjo	168	2	salt	salt	NN
cord-329876-4cgrjnjo	168	3	-	-	HYPH
cord-329876-4cgrjnjo	168	4	bridge	bridge	NN
cord-329876-4cgrjnjo	168	5	exists	exist	VBZ
cord-329876-4cgrjnjo	168	6	between	between	IN
cord-329876-4cgrjnjo	168	7	region	region	NN
cord-329876-4cgrjnjo	168	8	A	a	NN
cord-329876-4cgrjnjo	168	9	of	of	IN
cord-329876-4cgrjnjo	168	10	Ub	Ub	NNP
cord-329876-4cgrjnjo	168	11	and	and	CC
cord-329876-4cgrjnjo	168	12	the	the	DT
cord-329876-4cgrjnjo	168	13	PL	pl	NN
cord-329876-4cgrjnjo	168	14	pro	pro	FW
cord-329876-4cgrjnjo	168	15	(	(	-LRB-
cord-329876-4cgrjnjo	168	16	Figure	figure	NN
cord-329876-4cgrjnjo	168	17	2B	2b	CD
cord-329876-4cgrjnjo	168	18	)	)	-RRB-
cord-329876-4cgrjnjo	168	19	,	,	,
cord-329876-4cgrjnjo	168	20	namely	namely	RB
cord-329876-4cgrjnjo	168	21	between	between	IN
cord-329876-4cgrjnjo	168	22	the	the	DT
cord-329876-4cgrjnjo	168	23	side	side	NN
cord-329876-4cgrjnjo	168	24	-	-	HYPH
cord-329876-4cgrjnjo	168	25	chains	chain	NNS
cord-329876-4cgrjnjo	168	26	of	of	IN
cord-329876-4cgrjnjo	168	27	Arg42	Arg42	NNP
cord-329876-4cgrjnjo	169	1	and	and	CC
cord-329876-4cgrjnjo	169	2	Asp165	Asp165	NFP
cord-329876-4cgrjnjo	169	3	(	(	-LRB-
cord-329876-4cgrjnjo	169	4	region	region	NN
cord-329876-4cgrjnjo	169	5	II	II	NNP
cord-329876-4cgrjnjo	169	6	in	in	IN
cord-329876-4cgrjnjo	169	7	PL	pl	NN
cord-329876-4cgrjnjo	169	8	pro	pro	NN
cord-329876-4cgrjnjo	169	9	)	)	-RRB-
cord-329876-4cgrjnjo	169	10	.	.	.
cord-329876-4cgrjnjo	170	1	In	in	IN
cord-329876-4cgrjnjo	170	2	addition	addition	NN
cord-329876-4cgrjnjo	170	3	,	,	,
cord-329876-4cgrjnjo	170	4	a	a	DT
cord-329876-4cgrjnjo	170	5	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	170	6	bond	bond	NN
cord-329876-4cgrjnjo	170	7	is	be	VBZ
cord-329876-4cgrjnjo	170	8	formed	form	VBN
cord-329876-4cgrjnjo	170	9	between	between	IN
cord-329876-4cgrjnjo	170	10	the	the	DT
cord-329876-4cgrjnjo	170	11	main	main	JJ
cord-329876-4cgrjnjo	170	12	-	-	HYPH
cord-329876-4cgrjnjo	170	13	chain	chain	NN
cord-329876-4cgrjnjo	170	14	O	o	NN
cord-329876-4cgrjnjo	170	15	atom	atom	NN
cord-329876-4cgrjnjo	170	16	of	of	IN
cord-329876-4cgrjnjo	170	17	Gly47	Gly47	NNP
cord-329876-4cgrjnjo	170	18	and	and	CC
cord-329876-4cgrjnjo	170	19	the	the	DT
cord-329876-4cgrjnjo	170	20	main	main	JJ
cord-329876-4cgrjnjo	170	21	-	-	HYPH
cord-329876-4cgrjnjo	170	22	chain	chain	NN
cord-329876-4cgrjnjo	170	23	amide	amide	NN
cord-329876-4cgrjnjo	170	24	of	of	IN
cord-329876-4cgrjnjo	170	25	Val210	Val210	NNP
cord-329876-4cgrjnjo	170	26	(	(	-LRB-
cord-329876-4cgrjnjo	170	27	region	region	NN
cord-329876-4cgrjnjo	170	28	III	iii	CD
cord-329876-4cgrjnjo	170	29	)	)	-RRB-
cord-329876-4cgrjnjo	170	30	.	.	.
cord-329876-4cgrjnjo	171	1	In	in	IN
cord-329876-4cgrjnjo	171	2	the	the	DT
cord-329876-4cgrjnjo	171	3	SARS	SARS	NNP
cord-329876-4cgrjnjo	171	4	-	-	HYPH
cord-329876-4cgrjnjo	171	5	CoV	CoV	NNP
cord-329876-4cgrjnjo	171	6	PL	pl	NN
cord-329876-4cgrjnjo	171	7	pro	pro	JJ
cord-329876-4cgrjnjo	171	8	(	(	-LRB-
cord-329876-4cgrjnjo	171	9	C112S)-Ub	c112s)-ub	NN
cord-329876-4cgrjnjo	171	10	complex	complex	NN
cord-329876-4cgrjnjo	171	11	(	(	-LRB-
cord-329876-4cgrjnjo	171	12	Chou	Chou	NNP
cord-329876-4cgrjnjo	171	13	et	et	NNP
cord-329876-4cgrjnjo	171	14	al	al	NNP
cord-329876-4cgrjnjo	171	15	.	.	NNP
cord-329876-4cgrjnjo	171	16	,	,	,
cord-329876-4cgrjnjo	171	17	2014	2014	CD
cord-329876-4cgrjnjo	171	18	)	)	-RRB-
cord-329876-4cgrjnjo	171	19	,	,	,
cord-329876-4cgrjnjo	171	20	Arg42	Arg42	NNP
cord-329876-4cgrjnjo	171	21	forms	form	VBZ
cord-329876-4cgrjnjo	171	22	a	a	DT
cord-329876-4cgrjnjo	171	23	salt	salt	NN
cord-329876-4cgrjnjo	171	24	-	-	HYPH
cord-329876-4cgrjnjo	171	25	bridge	bridge	NN
cord-329876-4cgrjnjo	171	26	with	with	IN
cord-329876-4cgrjnjo	171	27	the	the	DT
cord-329876-4cgrjnjo	171	28	negatively	negatively	RB
cord-329876-4cgrjnjo	171	29	charged	charge	VBN
cord-329876-4cgrjnjo	171	30	Glu168	Glu168	NNP
cord-329876-4cgrjnjo	171	31	,	,	,
cord-329876-4cgrjnjo	171	32	a	a	DT
cord-329876-4cgrjnjo	171	33	residue	residue	NN
cord-329876-4cgrjnjo	171	34	which	which	WDT
cord-329876-4cgrjnjo	171	35	is	be	VBZ
cord-329876-4cgrjnjo	171	36	replaced	replace	VBN
cord-329876-4cgrjnjo	171	37	by	by	IN
cord-329876-4cgrjnjo	171	38	the	the	DT
cord-329876-4cgrjnjo	171	39	positively	positively	RB
cord-329876-4cgrjnjo	171	40	charged	charge	VBN
cord-329876-4cgrjnjo	171	41	Arg168	Arg168	,
cord-329876-4cgrjnjo	171	42	in	in	IN
cord-329876-4cgrjnjo	171	43	MERS	MERS	NNP
cord-329876-4cgrjnjo	171	44	-	-	HYPH
cord-329876-4cgrjnjo	171	45	CoV	CoV	NNP
cord-329876-4cgrjnjo	171	46	PL	pl	NN
cord-329876-4cgrjnjo	171	47	pro	pro	NNP
cord-329876-4cgrjnjo	171	48	.	.	.
cord-329876-4cgrjnjo	172	1	Consequently	consequently	RB
cord-329876-4cgrjnjo	172	2	,	,	,
cord-329876-4cgrjnjo	172	3	the	the	DT
cord-329876-4cgrjnjo	172	4	same	same	JJ
cord-329876-4cgrjnjo	172	5	salt	salt	NN
cord-329876-4cgrjnjo	172	6	-	-	HYPH
cord-329876-4cgrjnjo	172	7	bridge	bridge	NN
cord-329876-4cgrjnjo	172	8	can	can	MD
cord-329876-4cgrjnjo	172	9	not	not	RB
cord-329876-4cgrjnjo	172	10	be	be	VB
cord-329876-4cgrjnjo	172	11	formed	form	VBN
cord-329876-4cgrjnjo	172	12	in	in	IN
cord-329876-4cgrjnjo	172	13	the	the	DT
cord-329876-4cgrjnjo	172	14	MERS	MERS	NNP
cord-329876-4cgrjnjo	172	15	-	-	HYPH
cord-329876-4cgrjnjo	172	16	CoV	cov	NN
cord-329876-4cgrjnjo	172	17	PL	pl	NN
cord-329876-4cgrjnjo	172	18	pro	pro	JJ
cord-329876-4cgrjnjo	172	19	(	(	-LRB-
cord-329876-4cgrjnjo	172	20	C111S	C111S	NNP
cord-329876-4cgrjnjo	172	21	)	)	-RRB-
cord-329876-4cgrjnjo	172	22	-Ub	-ub	NN
cord-329876-4cgrjnjo	172	23	complex	complex	JJ
cord-329876-4cgrjnjo	172	24	.	.	.
cord-329876-4cgrjnjo	173	1	Instead	instead	RB
cord-329876-4cgrjnjo	173	2	,	,	,
cord-329876-4cgrjnjo	173	3	MERS	MERS	NNP
cord-329876-4cgrjnjo	173	4	-	-	HYPH
cord-329876-4cgrjnjo	173	5	CoV	CoV	NNP
cord-329876-4cgrjnjo	173	6	PL	pl	NN
cord-329876-4cgrjnjo	173	7	pro	pro	NNP
cord-329876-4cgrjnjo	173	8	has	have	VBZ
cord-329876-4cgrjnjo	173	9	Asp165	Asp165	NFP
cord-329876-4cgrjnjo	173	10	interacting	interact	VBG
cord-329876-4cgrjnjo	173	11	with	with	IN
cord-329876-4cgrjnjo	173	12	Arg42	Arg42	NNP
cord-329876-4cgrjnjo	173	13	.	.	.
cord-329876-4cgrjnjo	174	1	In	in	IN
cord-329876-4cgrjnjo	174	2	our	-PRON-	PRP$
cord-329876-4cgrjnjo	174	3	deubiquitinating	deubiquitinating	NN
cord-329876-4cgrjnjo	174	4	(	(	-LRB-
cord-329876-4cgrjnjo	174	5	DUB	DUB	NNP
cord-329876-4cgrjnjo	174	6	)	)	-RRB-
cord-329876-4cgrjnjo	174	7	kinetic	kinetic	JJ
cord-329876-4cgrjnjo	174	8	assays	assay	NNS
cord-329876-4cgrjnjo	174	9	,	,	,
cord-329876-4cgrjnjo	174	10	the	the	DT
cord-329876-4cgrjnjo	174	11	D165A	d165a	NN
cord-329876-4cgrjnjo	174	12	variant	variant	NN
cord-329876-4cgrjnjo	174	13	shows	show	VBZ
cord-329876-4cgrjnjo	174	14	a	a	DT
cord-329876-4cgrjnjo	174	15	dramatically	dramatically	RB
cord-329876-4cgrjnjo	174	16	reduced	reduce	VBN
cord-329876-4cgrjnjo	174	17	DUB	dub	NN
cord-329876-4cgrjnjo	174	18	activity	activity	NN
cord-329876-4cgrjnjo	174	19	;	;	:
cord-329876-4cgrjnjo	174	20	the	the	DT
cord-329876-4cgrjnjo	174	21	k	k	NNP
cord-329876-4cgrjnjo	174	22	cat	cat	NN
cord-329876-4cgrjnjo	174	23	/K	/K	.
cord-329876-4cgrjnjo	174	24	M	M	NNP
cord-329876-4cgrjnjo	174	25	is	be	VBZ
cord-329876-4cgrjnjo	174	26	about	about	RB
cord-329876-4cgrjnjo	174	27	78-fold	78-fold	CD
cord-329876-4cgrjnjo	174	28	decreased	decrease	VBD
cord-329876-4cgrjnjo	174	29	compared	compare	VBN
cord-329876-4cgrjnjo	174	30	to	to	IN
cord-329876-4cgrjnjo	174	31	that	that	DT
cord-329876-4cgrjnjo	174	32	of	of	IN
cord-329876-4cgrjnjo	174	33	the	the	DT
cord-329876-4cgrjnjo	174	34	wild	wild	JJ
cord-329876-4cgrjnjo	174	35	-	-	HYPH
cord-329876-4cgrjnjo	174	36	type	type	NN
cord-329876-4cgrjnjo	174	37	(	(	-LRB-
cord-329876-4cgrjnjo	174	38	Table	table	NN
cord-329876-4cgrjnjo	174	39	2	2	CD
cord-329876-4cgrjnjo	174	40	)	)	-RRB-
cord-329876-4cgrjnjo	174	41	.	.	.
cord-329876-4cgrjnjo	175	1	The	the	DT
cord-329876-4cgrjnjo	175	2	K	K	NNP
cord-329876-4cgrjnjo	175	3	M	M	NNP
cord-329876-4cgrjnjo	175	4	value	value	NN
cord-329876-4cgrjnjo	175	5	of	of	IN
cord-329876-4cgrjnjo	175	6	the	the	DT
cord-329876-4cgrjnjo	175	7	D165A	d165a	NN
cord-329876-4cgrjnjo	175	8	variant	variant	NN
cord-329876-4cgrjnjo	175	9	is	be	VBZ
cord-329876-4cgrjnjo	175	10	about	about	RB
cord-329876-4cgrjnjo	175	11	4-fold	4-fold	CD
cord-329876-4cgrjnjo	175	12	higher	high	JJR
cord-329876-4cgrjnjo	175	13	than	than	IN
cord-329876-4cgrjnjo	175	14	that	that	DT
cord-329876-4cgrjnjo	175	15	of	of	IN
cord-329876-4cgrjnjo	175	16	the	the	DT
cord-329876-4cgrjnjo	175	17	wild	wild	JJ
cord-329876-4cgrjnjo	175	18	-	-	HYPH
cord-329876-4cgrjnjo	175	19	type	type	NN
cord-329876-4cgrjnjo	175	20	MERS	MERS	NNP
cord-329876-4cgrjnjo	175	21	-	-	HYPH
cord-329876-4cgrjnjo	175	22	CoV	cov	NN
cord-329876-4cgrjnjo	175	23	PL	pl	NN
cord-329876-4cgrjnjo	175	24	pro	pro	NNP
cord-329876-4cgrjnjo	175	25	,	,	,
cord-329876-4cgrjnjo	175	26	suggesting	suggest	VBG
cord-329876-4cgrjnjo	175	27	that	that	IN
cord-329876-4cgrjnjo	175	28	this	this	DT
cord-329876-4cgrjnjo	175	29	amino	amino	NN
cord-329876-4cgrjnjo	175	30	-	-	HYPH
cord-329876-4cgrjnjo	175	31	acid	acid	NN
cord-329876-4cgrjnjo	175	32	replacement	replacement	NN
cord-329876-4cgrjnjo	175	33	reduces	reduce	VBZ
cord-329876-4cgrjnjo	175	34	the	the	DT
cord-329876-4cgrjnjo	175	35	Ub	ub	JJ
cord-329876-4cgrjnjo	175	36	binding	binding	NN
cord-329876-4cgrjnjo	175	37	affinity	affinity	NN
cord-329876-4cgrjnjo	175	38	.	.	.
cord-329876-4cgrjnjo	176	1	Meanwhile	meanwhile	RB
cord-329876-4cgrjnjo	176	2	,	,	,
cord-329876-4cgrjnjo	176	3	the	the	DT
cord-329876-4cgrjnjo	176	4	D165E	D165E	NNP
cord-329876-4cgrjnjo	176	5	amino	amino	NN
cord-329876-4cgrjnjo	176	6	-	-	HYPH
cord-329876-4cgrjnjo	176	7	acid	acid	NN
cord-329876-4cgrjnjo	176	8	replacement	replacement	NN
cord-329876-4cgrjnjo	176	9	shows	show	VBZ
cord-329876-4cgrjnjo	176	10	a	a	DT
cord-329876-4cgrjnjo	176	11	catalytic	catalytic	JJ
cord-329876-4cgrjnjo	176	12	efficiency	efficiency	NN
cord-329876-4cgrjnjo	176	13	comparable	comparable	JJ
cord-329876-4cgrjnjo	176	14	to	to	IN
cord-329876-4cgrjnjo	176	15	wild	wild	JJ
cord-329876-4cgrjnjo	176	16	-	-	HYPH
cord-329876-4cgrjnjo	176	17	type	type	NN
cord-329876-4cgrjnjo	176	18	towards	towards	IN
cord-329876-4cgrjnjo	176	19	Ub-7-amino-4methylcoumarin	ub-7-amino-4methylcoumarin	NN
cord-329876-4cgrjnjo	177	1	(	(	-LRB-
cord-329876-4cgrjnjo	177	2	Ub	Ub	NNP
cord-329876-4cgrjnjo	177	3	-	-	HYPH
cord-329876-4cgrjnjo	177	4	AMC	AMC	NNP
cord-329876-4cgrjnjo	177	5	)	)	-RRB-
cord-329876-4cgrjnjo	178	1	(	(	-LRB-
cord-329876-4cgrjnjo	178	2	Table	table	NN
cord-329876-4cgrjnjo	178	3	2	2	CD
cord-329876-4cgrjnjo	178	4	)	)	-RRB-
cord-329876-4cgrjnjo	178	5	.	.	.
cord-329876-4cgrjnjo	179	1	However	however	RB
cord-329876-4cgrjnjo	179	2	,	,	,
cord-329876-4cgrjnjo	179	3	we	-PRON-	PRP
cord-329876-4cgrjnjo	179	4	noticed	notice	VBD
cord-329876-4cgrjnjo	179	5	that	that	IN
cord-329876-4cgrjnjo	179	6	the	the	DT
cord-329876-4cgrjnjo	179	7	K	K	NNP
cord-329876-4cgrjnjo	179	8	M	M	NNP
cord-329876-4cgrjnjo	179	9	value	value	NN
cord-329876-4cgrjnjo	179	10	of	of	IN
cord-329876-4cgrjnjo	179	11	D165E	d165e	NN
cord-329876-4cgrjnjo	179	12	for	for	IN
cord-329876-4cgrjnjo	179	13	the	the	DT
cord-329876-4cgrjnjo	179	14	DUB	dub	NN
cord-329876-4cgrjnjo	179	15	activity	activity	NN
cord-329876-4cgrjnjo	179	16	is	be	VBZ
cord-329876-4cgrjnjo	179	17	about	about	RB
cord-329876-4cgrjnjo	179	18	2-fold	2-fold	RB
cord-329876-4cgrjnjo	179	19	larger	large	JJR
cord-329876-4cgrjnjo	179	20	than	than	IN
cord-329876-4cgrjnjo	179	21	for	for	IN
cord-329876-4cgrjnjo	179	22	the	the	DT
cord-329876-4cgrjnjo	179	23	WT	WT	NNP
cord-329876-4cgrjnjo	179	24	enzyme	enzyme	NN
cord-329876-4cgrjnjo	179	25	.	.	.
cord-329876-4cgrjnjo	180	1	Although	although	IN
cord-329876-4cgrjnjo	180	2	Glu165	glu165	DT
cord-329876-4cgrjnjo	180	3	can	can	MD
cord-329876-4cgrjnjo	180	4	mimic	mimic	VB
cord-329876-4cgrjnjo	180	5	Asp165	Asp165	.
cord-329876-4cgrjnjo	180	6	here	here	RB
cord-329876-4cgrjnjo	180	7	,	,	,
cord-329876-4cgrjnjo	180	8	we	-PRON-	PRP
cord-329876-4cgrjnjo	180	9	propose	propose	VBP
cord-329876-4cgrjnjo	180	10	that	that	IN
cord-329876-4cgrjnjo	180	11	the	the	DT
cord-329876-4cgrjnjo	180	12	longer	long	JJR
cord-329876-4cgrjnjo	180	13	side	side	NN
cord-329876-4cgrjnjo	180	14	-	-	HYPH
cord-329876-4cgrjnjo	180	15	chain	chain	NN
cord-329876-4cgrjnjo	180	16	of	of	IN
cord-329876-4cgrjnjo	180	17	Glu	Glu	NNP
cord-329876-4cgrjnjo	180	18	may	may	MD
cord-329876-4cgrjnjo	180	19	fit	fit	VB
cord-329876-4cgrjnjo	180	20	less	less	RBR
cord-329876-4cgrjnjo	180	21	perfectly	perfectly	RB
cord-329876-4cgrjnjo	180	22	compared	compare	VBN
cord-329876-4cgrjnjo	180	23	to	to	IN
cord-329876-4cgrjnjo	180	24	Asp	Asp	NNP
cord-329876-4cgrjnjo	180	25	.	.	.
cord-329876-4cgrjnjo	181	1	These	these	DT
cord-329876-4cgrjnjo	181	2	results	result	NNS
cord-329876-4cgrjnjo	181	3	indicate	indicate	VBP
cord-329876-4cgrjnjo	181	4	that	that	IN
cord-329876-4cgrjnjo	181	5	the	the	DT
cord-329876-4cgrjnjo	181	6	salt	salt	NN
cord-329876-4cgrjnjo	181	7	-	-	HYPH
cord-329876-4cgrjnjo	181	8	bridge	bridge	NN
cord-329876-4cgrjnjo	181	9	between	between	IN
cord-329876-4cgrjnjo	181	10	Asp165	Asp165	.
cord-329876-4cgrjnjo	182	1	and	and	CC
cord-329876-4cgrjnjo	182	2	Arg42	Arg42	NNP
cord-329876-4cgrjnjo	182	3	could	could	MD
cord-329876-4cgrjnjo	182	4	be	be	VB
cord-329876-4cgrjnjo	182	5	important	important	JJ
cord-329876-4cgrjnjo	182	6	for	for	IN
cord-329876-4cgrjnjo	182	7	the	the	DT
cord-329876-4cgrjnjo	182	8	PL	pl	NN
cord-329876-4cgrjnjo	182	9	pro	pro	NN
cord-329876-4cgrjnjo	182	10	's	's	POS
cord-329876-4cgrjnjo	182	11	DUB	dub	NN
cord-329876-4cgrjnjo	182	12	activity	activity	NN
cord-329876-4cgrjnjo	182	13	,	,	,
cord-329876-4cgrjnjo	182	14	in	in	IN
cord-329876-4cgrjnjo	182	15	addition	addition	NN
cord-329876-4cgrjnjo	182	16	to	to	IN
cord-329876-4cgrjnjo	182	17	the	the	DT
cord-329876-4cgrjnjo	182	18	interaction	interaction	NN
cord-329876-4cgrjnjo	182	19	between	between	IN
cord-329876-4cgrjnjo	182	20	Asp165	Asp165	.
cord-329876-4cgrjnjo	182	21	and	and	CC
cord-329876-4cgrjnjo	182	22	the	the	DT
cord-329876-4cgrjnjo	182	23	P4-amide	P4-amide	NNP
cord-329876-4cgrjnjo	182	24	group	group	NN
cord-329876-4cgrjnjo	182	25	(	(	-LRB-
cord-329876-4cgrjnjo	182	26	see	see	VB
cord-329876-4cgrjnjo	182	27	below	below	RB
cord-329876-4cgrjnjo	182	28	)	)	-RRB-
cord-329876-4cgrjnjo	182	29	.	.	.
cord-329876-4cgrjnjo	183	1	Region	region	NN
cord-329876-4cgrjnjo	183	2	B	B	NNP
cord-329876-4cgrjnjo	183	3	of	of	IN
cord-329876-4cgrjnjo	183	4	Ub	Ub	NNP
cord-329876-4cgrjnjo	183	5	comprises	comprise	VBZ
cord-329876-4cgrjnjo	183	6	the	the	DT
cord-329876-4cgrjnjo	183	7	five	five	CD
cord-329876-4cgrjnjo	183	8	C	c	NN
cord-329876-4cgrjnjo	183	9	-	-	HYPH
cord-329876-4cgrjnjo	183	10	terminal	terminal	NN
cord-329876-4cgrjnjo	183	11	residues	residue	NNS
cord-329876-4cgrjnjo	183	12	,	,	,
cord-329876-4cgrjnjo	183	13	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	183	14	.	.	.
cord-329876-4cgrjnjo	184	1	These	these	DT
cord-329876-4cgrjnjo	184	2	five	five	CD
cord-329876-4cgrjnjo	184	3	residues	residue	NNS
cord-329876-4cgrjnjo	184	4	bind	bind	VBP
cord-329876-4cgrjnjo	184	5	to	to	IN
cord-329876-4cgrjnjo	184	6	the	the	DT
cord-329876-4cgrjnjo	184	7	narrow	narrow	JJ
cord-329876-4cgrjnjo	184	8	activesite	activesite	JJ
cord-329876-4cgrjnjo	184	9	channel	channel	NN
cord-329876-4cgrjnjo	184	10	between	between	IN
cord-329876-4cgrjnjo	184	11	the	the	DT
cord-329876-4cgrjnjo	184	12	thumb	thumb	NN
cord-329876-4cgrjnjo	184	13	and	and	CC
cord-329876-4cgrjnjo	184	14	palm	palm	NN
cord-329876-4cgrjnjo	184	15	domains	domain	NNS
cord-329876-4cgrjnjo	184	16	of	of	IN
cord-329876-4cgrjnjo	184	17	the	the	DT
cord-329876-4cgrjnjo	184	18	PL	pl	NN
cord-329876-4cgrjnjo	184	19	pro	pro	FW
cord-329876-4cgrjnjo	184	20	(	(	-LRB-
cord-329876-4cgrjnjo	184	21	Figure	figure	NN
cord-329876-4cgrjnjo	184	22	2C	2c	NN
cord-329876-4cgrjnjo	184	23	)	)	-RRB-
cord-329876-4cgrjnjo	184	24	.	.	.
cord-329876-4cgrjnjo	185	1	They	-PRON-	PRP
cord-329876-4cgrjnjo	185	2	mainly	mainly	RB
cord-329876-4cgrjnjo	185	3	interact	interact	VBP
cord-329876-4cgrjnjo	185	4	with	with	IN
cord-329876-4cgrjnjo	185	5	regions	region	NNS
cord-329876-4cgrjnjo	185	6	I	-PRON-	PRP
cord-329876-4cgrjnjo	185	7	,	,	,
cord-329876-4cgrjnjo	185	8	II	II	NNP
cord-329876-4cgrjnjo	185	9	,	,	,
cord-329876-4cgrjnjo	185	10	IV	IV	NNP
cord-329876-4cgrjnjo	185	11	,	,	,
cord-329876-4cgrjnjo	185	12	and	and	CC
cord-329876-4cgrjnjo	185	13	V	v	NN
cord-329876-4cgrjnjo	185	14	of	of	IN
cord-329876-4cgrjnjo	185	15	the	the	DT
cord-329876-4cgrjnjo	185	16	protease	protease	NN
cord-329876-4cgrjnjo	185	17	.	.	.
cord-329876-4cgrjnjo	186	1	Residues	residue	NNS
cord-329876-4cgrjnjo	186	2	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	186	3	are	be	VBP
cord-329876-4cgrjnjo	186	4	compatible	compatible	JJ
cord-329876-4cgrjnjo	186	5	with	with	IN
cord-329876-4cgrjnjo	186	6	the	the	DT
cord-329876-4cgrjnjo	186	7	PL	pl	NN
cord-329876-4cgrjnjo	186	8	pro	pro	NN
cord-329876-4cgrjnjo	186	9	cleavage	cleavage	NN
cord-329876-4cgrjnjo	186	10	motif	motif	NN
cord-329876-4cgrjnjo	186	11	,	,	.
cord-329876-4cgrjnjo	187	1	(	(	-LRB-
cord-329876-4cgrjnjo	187	2	R	r	NN
cord-329876-4cgrjnjo	187	3	/	/	SYM
cord-329876-4cgrjnjo	187	4	K	k	NN
cord-329876-4cgrjnjo	187	5	)	)	-RRB-
cord-329876-4cgrjnjo	188	1	(	(	-LRB-
cord-329876-4cgrjnjo	188	2	L	L	NNP
cord-329876-4cgrjnjo	188	3	/	/	,
cord-329876-4cgrjnjo	188	4	I	i	NN
cord-329876-4cgrjnjo	188	5	)	)	-RRB-
cord-329876-4cgrjnjo	188	6	XGG	XGG	NNP
cord-329876-4cgrjnjo	188	7	(	(	-LRB-
cord-329876-4cgrjnjo	188	8	P5-P1	P5-P1	NNP
cord-329876-4cgrjnjo	188	9	)	)	-RRB-
cord-329876-4cgrjnjo	188	10	,	,	,
cord-329876-4cgrjnjo	188	11	in	in	IN
cord-329876-4cgrjnjo	188	12	the	the	DT
cord-329876-4cgrjnjo	188	13	MERS	MERS	NNP
cord-329876-4cgrjnjo	188	14	-	-	HYPH
cord-329876-4cgrjnjo	188	15	CoV	cov	NN
cord-329876-4cgrjnjo	188	16	polyproteins	polyprotein	NNS
cord-329876-4cgrjnjo	188	17	;	;	:
cord-329876-4cgrjnjo	188	18	their	-PRON-	PRP$
cord-329876-4cgrjnjo	188	19	interactions	interaction	NNS
cord-329876-4cgrjnjo	188	20	with	with	IN
cord-329876-4cgrjnjo	188	21	the	the	DT
cord-329876-4cgrjnjo	188	22	PL	pl	NN
cord-329876-4cgrjnjo	188	23	pro	pro	NN
cord-329876-4cgrjnjo	188	24	are	be	VBP
cord-329876-4cgrjnjo	188	25	discussed	discuss	VBN
cord-329876-4cgrjnjo	188	26	here	here	RB
cord-329876-4cgrjnjo	188	27	in	in	IN
cord-329876-4cgrjnjo	188	28	terms	term	NNS
cord-329876-4cgrjnjo	188	29	of	of	IN
cord-329876-4cgrjnjo	188	30	subsites	subsite	NNS
cord-329876-4cgrjnjo	188	31	S1	S1	NNP
cord-329876-4cgrjnjo	188	32	to	to	IN
cord-329876-4cgrjnjo	188	33	S5	S5	NNP
cord-329876-4cgrjnjo	188	34	.	.	.
cord-329876-4cgrjnjo	189	1	S1	S1	NNP
cord-329876-4cgrjnjo	189	2	and	and	CC
cord-329876-4cgrjnjo	189	3	S2	S2	NNP
cord-329876-4cgrjnjo	189	4	subsites	subsite	NNS
cord-329876-4cgrjnjo	189	5	.	.	.
cord-329876-4cgrjnjo	190	1	Pro163	Pro163	NNP
cord-329876-4cgrjnjo	190	2	(	(	-LRB-
cord-329876-4cgrjnjo	190	3	region	region	NN
cord-329876-4cgrjnjo	190	4	II	II	NNP
cord-329876-4cgrjnjo	190	5	of	of	IN
cord-329876-4cgrjnjo	190	6	PL	PL	NNP
cord-329876-4cgrjnjo	190	7	pro	pro	NN
cord-329876-4cgrjnjo	190	8	)	)	-RRB-
cord-329876-4cgrjnjo	191	1	and	and	CC
cord-329876-4cgrjnjo	191	2	the	the	DT
cord-329876-4cgrjnjo	191	3	side	side	NN
cord-329876-4cgrjnjo	191	4	-	-	HYPH
cord-329876-4cgrjnjo	191	5	chains	chain	NNS
cord-329876-4cgrjnjo	191	6	of	of	IN
cord-329876-4cgrjnjo	191	7	Asn109	asn109	CD
cord-329876-4cgrjnjo	191	8	and	and	CC
cord-329876-4cgrjnjo	191	9	Tyr112	Tyr112	NNP
cord-329876-4cgrjnjo	191	10	(	(	-LRB-
cord-329876-4cgrjnjo	191	11	located	locate	VBN
cord-329876-4cgrjnjo	191	12	in	in	IN
cord-329876-4cgrjnjo	191	13	region	region	NN
cord-329876-4cgrjnjo	191	14	I	-PRON-	PRP
cord-329876-4cgrjnjo	191	15	)	)	-RRB-
cord-329876-4cgrjnjo	191	16	form	form	VBP
cord-329876-4cgrjnjo	191	17	a	a	DT
cord-329876-4cgrjnjo	191	18	space	space	NN
cord-329876-4cgrjnjo	191	19	-	-	HYPH
cord-329876-4cgrjnjo	191	20	restricted	restrict	VBN
cord-329876-4cgrjnjo	191	21	S1	s1	NN
cord-329876-4cgrjnjo	191	22	site	site	NN
cord-329876-4cgrjnjo	191	23	to	to	TO
cord-329876-4cgrjnjo	191	24	accommodate	accommodate	VB
cord-329876-4cgrjnjo	191	25	Gly76	Gly76	NNP
cord-329876-4cgrjnjo	191	26	(	(	-LRB-
cord-329876-4cgrjnjo	191	27	P1	p1	NN
cord-329876-4cgrjnjo	191	28	)	)	-RRB-
cord-329876-4cgrjnjo	191	29	.	.	.
cord-329876-4cgrjnjo	192	1	The	the	DT
cord-329876-4cgrjnjo	192	2	carbonyl	carbonyl	NN
cord-329876-4cgrjnjo	192	3	oxygen	oxygen	NN
cord-329876-4cgrjnjo	192	4	atom	atom	NN
cord-329876-4cgrjnjo	192	5	of	of	IN
cord-329876-4cgrjnjo	192	6	Gly277	gly277	CD
cord-329876-4cgrjnjo	192	7	(	(	-LRB-
cord-329876-4cgrjnjo	192	8	region	region	NN
cord-329876-4cgrjnjo	192	9	V	V	NNP
cord-329876-4cgrjnjo	192	10	)	)	-RRB-
cord-329876-4cgrjnjo	192	11	accepts	accept	VBZ
cord-329876-4cgrjnjo	192	12	a	a	DT
cord-329876-4cgrjnjo	192	13	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	192	14	bond	bond	NN
cord-329876-4cgrjnjo	192	15	from	from	IN
cord-329876-4cgrjnjo	192	16	the	the	DT
cord-329876-4cgrjnjo	192	17	amide	amide	NN
cord-329876-4cgrjnjo	192	18	of	of	IN
cord-329876-4cgrjnjo	192	19	Gly76	Gly76	NNP
cord-329876-4cgrjnjo	192	20	(	(	-LRB-
cord-329876-4cgrjnjo	192	21	Figure	figure	NN
cord-329876-4cgrjnjo	192	22	3	3	CD
cord-329876-4cgrjnjo	192	23	)	)	-RRB-
cord-329876-4cgrjnjo	192	24	.	.	.
cord-329876-4cgrjnjo	193	1	The	the	DT
cord-329876-4cgrjnjo	193	2	side	side	NN
cord-329876-4cgrjnjo	193	3	-	-	HYPH
cord-329876-4cgrjnjo	193	4	chains	chain	NNS
cord-329876-4cgrjnjo	193	5	of	of	IN
cord-329876-4cgrjnjo	193	6	Tyr112	tyr112	DT
cord-329876-4cgrjnjo	193	7	(	(	-LRB-
cord-329876-4cgrjnjo	193	8	region	region	NN
cord-329876-4cgrjnjo	193	9	I	I	NNP
cord-329876-4cgrjnjo	193	10	)	)	-RRB-
cord-329876-4cgrjnjo	193	11	and	and	CC
cord-329876-4cgrjnjo	193	12	Phe269	phe269	IN
cord-329876-4cgrjnjo	193	13	,	,	,
cord-329876-4cgrjnjo	193	14	Val276	Val276	NFP
cord-329876-4cgrjnjo	193	15	as	as	RB
cord-329876-4cgrjnjo	193	16	well	well	RB
cord-329876-4cgrjnjo	193	17	as	as	IN
cord-329876-4cgrjnjo	193	18	Tyr279	tyr279	CD
cord-329876-4cgrjnjo	193	19	(	(	-LRB-
cord-329876-4cgrjnjo	193	20	region	region	NN
cord-329876-4cgrjnjo	193	21	V	V	NNP
cord-329876-4cgrjnjo	193	22	)	)	-RRB-
cord-329876-4cgrjnjo	193	23	,	,	,
cord-329876-4cgrjnjo	193	24	and	and	CC
cord-329876-4cgrjnjo	193	25	Gly277	gly277	DT
cord-329876-4cgrjnjo	193	26	form	form	VB
cord-329876-4cgrjnjo	193	27	a	a	DT
cord-329876-4cgrjnjo	193	28	restricted	restrict	VBN
cord-329876-4cgrjnjo	193	29	space	space	NN
cord-329876-4cgrjnjo	193	30	for	for	IN
cord-329876-4cgrjnjo	193	31	Gly75	Gly75	NNP
cord-329876-4cgrjnjo	193	32	(	(	-LRB-
cord-329876-4cgrjnjo	193	33	P2	P2	NNP
cord-329876-4cgrjnjo	193	34	)	)	-RRB-
cord-329876-4cgrjnjo	193	35	.	.	.
cord-329876-4cgrjnjo	194	1	Two	two	CD
cord-329876-4cgrjnjo	194	2	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	194	3	bonds	bond	NNS
cord-329876-4cgrjnjo	194	4	link	link	VBP
cord-329876-4cgrjnjo	194	5	the	the	DT
cord-329876-4cgrjnjo	194	6	main	main	JJ
cord-329876-4cgrjnjo	194	7	-	-	HYPH
cord-329876-4cgrjnjo	194	8	chain	chain	NN
cord-329876-4cgrjnjo	194	9	at	at	IN
cord-329876-4cgrjnjo	194	10	Asp164	asp164	CD
cord-329876-4cgrjnjo	194	11	of	of	IN
cord-329876-4cgrjnjo	194	12	the	the	DT
cord-329876-4cgrjnjo	194	13	PL	pl	NN
cord-329876-4cgrjnjo	194	14	pro	pro	NN
cord-329876-4cgrjnjo	194	15	and	and	CC
cord-329876-4cgrjnjo	194	16	Gly75	Gly75	NNP
cord-329876-4cgrjnjo	194	17	(	(	-LRB-
cord-329876-4cgrjnjo	194	18	Figure	Figure	NNP
cord-329876-4cgrjnjo	194	19	3	3	CD
cord-329876-4cgrjnjo	194	20	)	)	-RRB-
cord-329876-4cgrjnjo	194	21	.	.	.
cord-329876-4cgrjnjo	195	1	The	the	DT
cord-329876-4cgrjnjo	195	2	S1	s1	NN
cord-329876-4cgrjnjo	195	3	and	and	CC
cord-329876-4cgrjnjo	195	4	S2	s2	NN
cord-329876-4cgrjnjo	195	5	sites	site	NNS
cord-329876-4cgrjnjo	195	6	of	of	IN
cord-329876-4cgrjnjo	195	7	the	the	DT
cord-329876-4cgrjnjo	195	8	protease	protease	NN
cord-329876-4cgrjnjo	195	9	are	be	VBP
cord-329876-4cgrjnjo	195	10	too	too	RB
cord-329876-4cgrjnjo	195	11	small	small	JJ
cord-329876-4cgrjnjo	195	12	to	to	TO
cord-329876-4cgrjnjo	195	13	accommodate	accommodate	VB
cord-329876-4cgrjnjo	195	14	any	any	DT
cord-329876-4cgrjnjo	195	15	other	other	JJ
cord-329876-4cgrjnjo	195	16	residue	residue	NN
cord-329876-4cgrjnjo	195	17	but	but	CC
cord-329876-4cgrjnjo	195	18	glycine	glycine	NN
cord-329876-4cgrjnjo	195	19	.	.	.
cord-329876-4cgrjnjo	196	1	S3	S3	NNP
cord-329876-4cgrjnjo	196	2	subsite	subsite	NN
cord-329876-4cgrjnjo	196	3	.	.	.
cord-329876-4cgrjnjo	197	1	The	the	DT
cord-329876-4cgrjnjo	197	2	main	main	JJ
cord-329876-4cgrjnjo	197	3	-	-	HYPH
cord-329876-4cgrjnjo	197	4	chain	chain	NN
cord-329876-4cgrjnjo	197	5	O	o	NN
cord-329876-4cgrjnjo	197	6	atom	atom	NN
cord-329876-4cgrjnjo	197	7	of	of	IN
cord-329876-4cgrjnjo	197	8	Arg74	Arg74	NNP
cord-329876-4cgrjnjo	197	9	(	(	-LRB-
cord-329876-4cgrjnjo	197	10	P3	P3	NNP
cord-329876-4cgrjnjo	197	11	)	)	-RRB-
cord-329876-4cgrjnjo	197	12	accepts	accept	VBZ
cord-329876-4cgrjnjo	197	13	a	a	DT
cord-329876-4cgrjnjo	197	14	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	197	15	bond	bond	NN
cord-329876-4cgrjnjo	197	16	from	from	IN
cord-329876-4cgrjnjo	197	17	the	the	DT
cord-329876-4cgrjnjo	197	18	Gly277	gly277	CD
cord-329876-4cgrjnjo	197	19	amide	amide	NN
cord-329876-4cgrjnjo	197	20	.	.	.
cord-329876-4cgrjnjo	198	1	In	in	IN
cord-329876-4cgrjnjo	198	2	the	the	DT
cord-329876-4cgrjnjo	198	3	complexes	complex	NNS
cord-329876-4cgrjnjo	198	4	SARS	SARS	NNP
cord-329876-4cgrjnjo	198	5	-	-	HYPH
cord-329876-4cgrjnjo	198	6	CoV	CoV	NNP
cord-329876-4cgrjnjo	198	7	PL	pl	NN
cord-329876-4cgrjnjo	198	8	pro	pro	JJ
cord-329876-4cgrjnjo	198	9	(	(	-LRB-
cord-329876-4cgrjnjo	198	10	C112S)-Ub	C112S)-Ub	NNP
cord-329876-4cgrjnjo	198	11	or	or	CC
cord-329876-4cgrjnjo	198	12	SARS	SARS	NNP
cord-329876-4cgrjnjo	198	13	-	-	HYPH
cord-329876-4cgrjnjo	198	14	CoV	CoV	NNP
cord-329876-4cgrjnjo	198	15	PL	PL	NNP
cord-329876-4cgrjnjo	198	16	pro	pro	NNP
cord-329876-4cgrjnjo	198	17	-Ubal	-Ubal	NNP
cord-329876-4cgrjnjo	198	18	,	,	,
cord-329876-4cgrjnjo	198	19	the	the	DT
cord-329876-4cgrjnjo	198	20	main	main	JJ
cord-329876-4cgrjnjo	198	21	chain	chain	NN
cord-329876-4cgrjnjo	198	22	at	at	IN
cord-329876-4cgrjnjo	198	23	Arg74	Arg74	NNP
cord-329876-4cgrjnjo	198	24	forms	form	VBZ
cord-329876-4cgrjnjo	198	25	two	two	CD
cord-329876-4cgrjnjo	198	26	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	198	27	bonds	bond	NNS
cord-329876-4cgrjnjo	198	28	(	(	-LRB-
cord-329876-4cgrjnjo	198	29	Chou	Chou	NNP
cord-329876-4cgrjnjo	198	30	et	et	NNP
cord-329876-4cgrjnjo	198	31	al	al	NNP
cord-329876-4cgrjnjo	198	32	.	.	NNP
cord-329876-4cgrjnjo	198	33	,	,	,
cord-329876-4cgrjnjo	198	34	2014	2014	CD
cord-329876-4cgrjnjo	198	35	;	;	.
cord-329876-4cgrjnjo	199	1	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	199	2	et	et	NNP
cord-329876-4cgrjnjo	199	3	al	al	NNP
cord-329876-4cgrjnjo	199	4	.	.	NNP
cord-329876-4cgrjnjo	199	5	,	,	,
cord-329876-4cgrjnjo	199	6	2014	2014	CD
cord-329876-4cgrjnjo	199	7	)	)	-RRB-
cord-329876-4cgrjnjo	199	8	,	,	,
cord-329876-4cgrjnjo	199	9	namely	namely	RB
cord-329876-4cgrjnjo	199	10	with	with	IN
cord-329876-4cgrjnjo	199	11	the	the	DT
cord-329876-4cgrjnjo	199	12	amide	amide	NN
cord-329876-4cgrjnjo	199	13	of	of	IN
cord-329876-4cgrjnjo	199	14	Gly272	gly272	CD
cord-329876-4cgrjnjo	199	15	and	and	CC
cord-329876-4cgrjnjo	199	16	with	with	IN
cord-329876-4cgrjnjo	199	17	the	the	DT
cord-329876-4cgrjnjo	199	18	hydroxyl	hydroxyl	NN
cord-329876-4cgrjnjo	199	19	group	group	NN
cord-329876-4cgrjnjo	199	20	of	of	IN
cord-329876-4cgrjnjo	199	21	Tyr265	tyr265	CD
cord-329876-4cgrjnjo	199	22	.	.	.
cord-329876-4cgrjnjo	200	1	The	the	DT
cord-329876-4cgrjnjo	200	2	former	former	JJ
cord-329876-4cgrjnjo	200	3	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	200	4	bond	bond	NN
cord-329876-4cgrjnjo	200	5	is	be	VBZ
cord-329876-4cgrjnjo	200	6	conserved	conserve	VBN
cord-329876-4cgrjnjo	200	7	in	in	IN
cord-329876-4cgrjnjo	200	8	the	the	DT
cord-329876-4cgrjnjo	200	9	MERS	MERS	NNP
cord-329876-4cgrjnjo	200	10	-	-	HYPH
cord-329876-4cgrjnjo	200	11	CoV	cov	NN
cord-329876-4cgrjnjo	200	12	PL	pl	NN
cord-329876-4cgrjnjo	200	13	pro	pro	JJ
cord-329876-4cgrjnjo	200	14	(	(	-LRB-
cord-329876-4cgrjnjo	200	15	C111S)-Ub	c111s)-ub	NN
cord-329876-4cgrjnjo	200	16	complex	complex	NN
cord-329876-4cgrjnjo	200	17	,	,	,
cord-329876-4cgrjnjo	200	18	but	but	CC
cord-329876-4cgrjnjo	200	19	the	the	DT
cord-329876-4cgrjnjo	200	20	latter	latter	JJ
cord-329876-4cgrjnjo	200	21	is	be	VBZ
cord-329876-4cgrjnjo	200	22	not	not	RB
cord-329876-4cgrjnjo	200	23	.	.	.
cord-329876-4cgrjnjo	201	1	Tyr265	tyr265	CD
cord-329876-4cgrjnjo	201	2	of	of	IN
cord-329876-4cgrjnjo	201	3	SARS	SARS	NNP
cord-329876-4cgrjnjo	201	4	-	-	HYPH
cord-329876-4cgrjnjo	201	5	CoV	CoV	NNP
cord-329876-4cgrjnjo	201	6	is	be	VBZ
cord-329876-4cgrjnjo	201	7	replaced	replace	VBN
cord-329876-4cgrjnjo	201	8	by	by	IN
cord-329876-4cgrjnjo	201	9	Phe269	phe269	CD
cord-329876-4cgrjnjo	201	10	in	in	IN
cord-329876-4cgrjnjo	201	11	MERS	MERS	NNP
cord-329876-4cgrjnjo	201	12	-	-	HYPH
cord-329876-4cgrjnjo	201	13	CoV	CoV	NNP
cord-329876-4cgrjnjo	201	14	,	,	,
cord-329876-4cgrjnjo	201	15	which	which	WDT
cord-329876-4cgrjnjo	201	16	lacks	lack	VBZ
cord-329876-4cgrjnjo	201	17	the	the	DT
cord-329876-4cgrjnjo	201	18	ability	ability	NN
cord-329876-4cgrjnjo	201	19	to	to	TO
cord-329876-4cgrjnjo	201	20	form	form	VB
cord-329876-4cgrjnjo	201	21	a	a	DT
cord-329876-4cgrjnjo	201	22	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	201	23	bond	bond	NN
cord-329876-4cgrjnjo	201	24	with	with	IN
cord-329876-4cgrjnjo	201	25	the	the	DT
cord-329876-4cgrjnjo	201	26	main	main	JJ
cord-329876-4cgrjnjo	201	27	-	-	HYPH
cord-329876-4cgrjnjo	201	28	chain	chain	NN
cord-329876-4cgrjnjo	201	29	amide	amide	NN
cord-329876-4cgrjnjo	201	30	of	of	IN
cord-329876-4cgrjnjo	201	31	Arg74	Arg74	NNP
cord-329876-4cgrjnjo	201	32	.	.	.
cord-329876-4cgrjnjo	202	1	In	in	IN
cord-329876-4cgrjnjo	202	2	agreement	agreement	NN
cord-329876-4cgrjnjo	202	3	with	with	IN
cord-329876-4cgrjnjo	202	4	this	this	DT
cord-329876-4cgrjnjo	202	5	difference	difference	NN
cord-329876-4cgrjnjo	202	6	,	,	,
cord-329876-4cgrjnjo	202	7	the	the	DT
cord-329876-4cgrjnjo	202	8	DUB	dub	NN
cord-329876-4cgrjnjo	202	9	activity	activity	NN
cord-329876-4cgrjnjo	202	10	of	of	IN
cord-329876-4cgrjnjo	202	11	SARS	SARS	NNP
cord-329876-4cgrjnjo	202	12	-	-	HYPH
cord-329876-4cgrjnjo	202	13	CoV	CoV	NNP
cord-329876-4cgrjnjo	202	14	PL	pl	NN
cord-329876-4cgrjnjo	202	15	pro	pro	NNP
cord-329876-4cgrjnjo	202	16	is	be	VBZ
cord-329876-4cgrjnjo	202	17	2.5-fold	2.5-fold	CD
cord-329876-4cgrjnjo	202	18	higher	high	JJR
cord-329876-4cgrjnjo	202	19	than	than	IN
cord-329876-4cgrjnjo	202	20	that	that	DT
cord-329876-4cgrjnjo	202	21	of	of	IN
cord-329876-4cgrjnjo	202	22	MERS	MERS	NNP
cord-329876-4cgrjnjo	202	23	-	-	HYPH
cord-329876-4cgrjnjo	202	24	CoV	CoV	NNP
cord-329876-4cgrjnjo	202	25	PL	pl	NN
cord-329876-4cgrjnjo	202	26	pro	pro	JJ
cord-329876-4cgrjnjo	202	27	in	in	IN
cord-329876-4cgrjnjo	202	28	our	-PRON-	PRP$
cord-329876-4cgrjnjo	202	29	kinetic	kinetic	JJ
cord-329876-4cgrjnjo	202	30	assay	assay	NN
cord-329876-4cgrjnjo	202	31	;	;	:
cord-329876-4cgrjnjo	202	32	furthermore	furthermore	RB
cord-329876-4cgrjnjo	202	33	,	,	,
cord-329876-4cgrjnjo	202	34	the	the	DT
cord-329876-4cgrjnjo	202	35	MERS	MERS	NNP
cord-329876-4cgrjnjo	202	36	-	-	HYPH
cord-329876-4cgrjnjo	202	37	CoV	cov	NN
cord-329876-4cgrjnjo	202	38	PL	pl	NN
cord-329876-4cgrjnjo	202	39	pro	pro	JJ
cord-329876-4cgrjnjo	202	40	F269Y	F269Y	NNP
cord-329876-4cgrjnjo	202	41	amino	amino	NN
cord-329876-4cgrjnjo	202	42	-	-	HYPH
cord-329876-4cgrjnjo	202	43	acid	acid	NN
cord-329876-4cgrjnjo	202	44	replacement	replacement	NN
cord-329876-4cgrjnjo	202	45	leads	lead	VBZ
cord-329876-4cgrjnjo	202	46	to	to	IN
cord-329876-4cgrjnjo	202	47	enhancements	enhancement	NNS
cord-329876-4cgrjnjo	202	48	by	by	IN
cord-329876-4cgrjnjo	202	49	about	about	IN
cord-329876-4cgrjnjo	202	50	1.5-	1.5-	CD
cord-329876-4cgrjnjo	202	51	,	,	,
cord-329876-4cgrjnjo	202	52	1.4-	1.4-	CD
cord-329876-4cgrjnjo	202	53	,	,	,
cord-329876-4cgrjnjo	202	54	and	and	CC
cord-329876-4cgrjnjo	202	55	1.9-fold	1.9-fold	CD
cord-329876-4cgrjnjo	202	56	of	of	IN
cord-329876-4cgrjnjo	202	57	the	the	DT
cord-329876-4cgrjnjo	202	58	hydrolytic	hydrolytic	JJ
cord-329876-4cgrjnjo	202	59	activities	activity	NNS
cord-329876-4cgrjnjo	202	60	towards	towards	IN
cord-329876-4cgrjnjo	202	61	carbobenzoxy	carbobenzoxy	NN
cord-329876-4cgrjnjo	202	62	-	-	HYPH
cord-329876-4cgrjnjo	202	63	Arg	Arg	NNP
cord-329876-4cgrjnjo	202	64	-	-	HYPH
cord-329876-4cgrjnjo	202	65	Leu	Leu	NNP
cord-329876-4cgrjnjo	202	66	-	-	HYPH
cord-329876-4cgrjnjo	202	67	Arg	Arg	NNP
cord-329876-4cgrjnjo	202	68	-	-	HYPH
cord-329876-4cgrjnjo	202	69	Gly	Gly	NNP
cord-329876-4cgrjnjo	202	70	-	-	HYPH
cord-329876-4cgrjnjo	202	71	Gly-7amino-4-methylcoumarin	Gly-7amino-4-methylcoumarin	NNP
cord-329876-4cgrjnjo	202	72	(	(	-LRB-
cord-329876-4cgrjnjo	202	73	Z	z	NN
cord-329876-4cgrjnjo	202	74	-	-	HYPH
cord-329876-4cgrjnjo	202	75	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	202	76	-	-	HYPH
cord-329876-4cgrjnjo	202	77	AMC	AMC	NNP
cord-329876-4cgrjnjo	202	78	)	)	-RRB-
cord-329876-4cgrjnjo	202	79	,	,	,
cord-329876-4cgrjnjo	202	80	Z	Z	NNP
cord-329876-4cgrjnjo	202	81	-	-	HYPH
cord-329876-4cgrjnjo	202	82	LRGG	LRGG	NNP
cord-329876-4cgrjnjo	202	83	-	-	HYPH
cord-329876-4cgrjnjo	202	84	AMC	AMC	NNP
cord-329876-4cgrjnjo	202	85	,	,	,
cord-329876-4cgrjnjo	202	86	and	and	CC
cord-329876-4cgrjnjo	202	87	Ub	Ub	NNP
cord-329876-4cgrjnjo	202	88	-	-	HYPH
cord-329876-4cgrjnjo	202	89	AMC	AMC	NNP
cord-329876-4cgrjnjo	202	90	,	,	,
cord-329876-4cgrjnjo	202	91	respectively	respectively	RB
cord-329876-4cgrjnjo	202	92	(	(	-LRB-
cord-329876-4cgrjnjo	202	93	Table	table	NN
cord-329876-4cgrjnjo	202	94	2	2	CD
cord-329876-4cgrjnjo	202	95	)	)	-RRB-
cord-329876-4cgrjnjo	202	96	.	.	.
cord-329876-4cgrjnjo	203	1	The	the	DT
cord-329876-4cgrjnjo	203	2	side	side	NN
cord-329876-4cgrjnjo	203	3	-	-	HYPH
cord-329876-4cgrjnjo	203	4	chain	chain	NN
cord-329876-4cgrjnjo	203	5	of	of	IN
cord-329876-4cgrjnjo	203	6	Arg74	Arg74	NNP
cord-329876-4cgrjnjo	203	7	is	be	VBZ
cord-329876-4cgrjnjo	203	8	exposed	expose	VBN
cord-329876-4cgrjnjo	203	9	to	to	IN
cord-329876-4cgrjnjo	203	10	the	the	DT
cord-329876-4cgrjnjo	203	11	solvent	solvent	NN
cord-329876-4cgrjnjo	203	12	in	in	IN
cord-329876-4cgrjnjo	203	13	our	-PRON-	PRP$
cord-329876-4cgrjnjo	203	14	MERS	MERS	NNP
cord-329876-4cgrjnjo	203	15	-	-	HYPH
cord-329876-4cgrjnjo	203	16	CoV	cov	NN
cord-329876-4cgrjnjo	203	17	PL	pl	NN
cord-329876-4cgrjnjo	203	18	pro	pro	JJ
cord-329876-4cgrjnjo	203	19	(	(	-LRB-
cord-329876-4cgrjnjo	203	20	C111S)-Ub	c111s)-ub	NN
cord-329876-4cgrjnjo	203	21	complex	complex	NN
cord-329876-4cgrjnjo	203	22	.	.	.
cord-329876-4cgrjnjo	204	1	This	this	DT
cord-329876-4cgrjnjo	204	2	sidechain	sidechain	NN
cord-329876-4cgrjnjo	204	3	shows	show	VBZ
cord-329876-4cgrjnjo	204	4	remarkable	remarkable	JJ
cord-329876-4cgrjnjo	204	5	variability	variability	NN
cord-329876-4cgrjnjo	204	6	in	in	IN
cord-329876-4cgrjnjo	204	7	the	the	DT
cord-329876-4cgrjnjo	204	8	interactions	interaction	NNS
cord-329876-4cgrjnjo	204	9	it	-PRON-	PRP
cord-329876-4cgrjnjo	204	10	makes	make	VBZ
cord-329876-4cgrjnjo	204	11	in	in	IN
cord-329876-4cgrjnjo	204	12	the	the	DT
cord-329876-4cgrjnjo	204	13	different	different	JJ
cord-329876-4cgrjnjo	204	14	complexes	complex	NNS
cord-329876-4cgrjnjo	204	15	.	.	.
cord-329876-4cgrjnjo	205	1	In	in	IN
cord-329876-4cgrjnjo	205	2	the	the	DT
cord-329876-4cgrjnjo	205	3	"	"	``
cord-329876-4cgrjnjo	205	4	open	open	JJ
cord-329876-4cgrjnjo	205	5	"	"	''
cord-329876-4cgrjnjo	205	6	but	but	CC
cord-329876-4cgrjnjo	205	7	not	not	RB
cord-329876-4cgrjnjo	205	8	in	in	IN
cord-329876-4cgrjnjo	205	9	the	the	DT
cord-329876-4cgrjnjo	205	10	"	"	``
cord-329876-4cgrjnjo	205	11	closed	closed	JJ
cord-329876-4cgrjnjo	205	12	"	"	''
cord-329876-4cgrjnjo	205	13	covalent	covalent	JJ
cord-329876-4cgrjnjo	205	14	MERS	MERS	NNP
cord-329876-4cgrjnjo	205	15	-	-	HYPH
cord-329876-4cgrjnjo	205	16	CoV	cov	NN
cord-329876-4cgrjnjo	205	17	PL	pl	NN
cord-329876-4cgrjnjo	205	18	pro	pro	JJ
cord-329876-4cgrjnjo	205	19	-Ub	-ub	NN
cord-329876-4cgrjnjo	205	20	complex	complex	JJ
cord-329876-4cgrjnjo	206	1	(	(	-LRB-
cord-329876-4cgrjnjo	206	2	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	206	3	-	-	HYPH
cord-329876-4cgrjnjo	206	4	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	206	5	et	et	NNP
cord-329876-4cgrjnjo	206	6	al	al	NNP
cord-329876-4cgrjnjo	206	7	.	.	NNP
cord-329876-4cgrjnjo	206	8	,	,	,
cord-329876-4cgrjnjo	206	9	2014	2014	CD
cord-329876-4cgrjnjo	206	10	)	)	-RRB-
cord-329876-4cgrjnjo	206	11	,	,	,
cord-329876-4cgrjnjo	206	12	it	-PRON-	PRP
cord-329876-4cgrjnjo	206	13	donates	donate	VBZ
cord-329876-4cgrjnjo	206	14	a	a	DT
cord-329876-4cgrjnjo	206	15	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	206	16	bond	bond	NN
cord-329876-4cgrjnjo	206	17	to	to	IN
cord-329876-4cgrjnjo	206	18	the	the	DT
cord-329876-4cgrjnjo	206	19	main	main	JJ
cord-329876-4cgrjnjo	206	20	-	-	HYPH
cord-329876-4cgrjnjo	206	21	chain	chain	NN
cord-329876-4cgrjnjo	206	22	carbonyl	carbonyl	NN
cord-329876-4cgrjnjo	206	23	oxygen	oxygen	NN
cord-329876-4cgrjnjo	206	24	of	of	IN
cord-329876-4cgrjnjo	206	25	Thr1755	Thr1755	NNP
cord-329876-4cgrjnjo	206	26	of	of	IN
cord-329876-4cgrjnjo	206	27	the	the	DT
cord-329876-4cgrjnjo	206	28	BL2	BL2	NNP
cord-329876-4cgrjnjo	206	29	loop	loop	NN
cord-329876-4cgrjnjo	206	30	(	(	-LRB-
cord-329876-4cgrjnjo	206	31	corresponding	correspond	VBG
cord-329876-4cgrjnjo	206	32	to	to	IN
cord-329876-4cgrjnjo	206	33	Thr274	thr274	CD
cord-329876-4cgrjnjo	206	34	in	in	IN
cord-329876-4cgrjnjo	206	35	our	-PRON-	PRP$
cord-329876-4cgrjnjo	206	36	numbering	number	VBG
cord-329876-4cgrjnjo	206	37	scheme	scheme	NN
cord-329876-4cgrjnjo	206	38	)	)	-RRB-
cord-329876-4cgrjnjo	206	39	.	.	.
cord-329876-4cgrjnjo	207	1	In	in	IN
cord-329876-4cgrjnjo	207	2	SARS	SARS	NNP
cord-329876-4cgrjnjo	207	3	-	-	HYPH
cord-329876-4cgrjnjo	207	4	CoV	CoV	NNP
cord-329876-4cgrjnjo	207	5	PL	pl	NN
cord-329876-4cgrjnjo	207	6	pro	pro	NNP
cord-329876-4cgrjnjo	207	7	-Ubal	-Ubal	NNP
cord-329876-4cgrjnjo	208	1	(	(	-LRB-
cord-329876-4cgrjnjo	208	2	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	208	3	et	et	NNP
cord-329876-4cgrjnjo	208	4	al	al	NNP
cord-329876-4cgrjnjo	208	5	.	.	NNP
cord-329876-4cgrjnjo	208	6	,	,	,
cord-329876-4cgrjnjo	208	7	2014	2014	CD
cord-329876-4cgrjnjo	208	8	)	)	-RRB-
cord-329876-4cgrjnjo	209	1	but	but	CC
cord-329876-4cgrjnjo	209	2	not	not	RB
cord-329876-4cgrjnjo	209	3	in	in	IN
cord-329876-4cgrjnjo	209	4	the	the	DT
cord-329876-4cgrjnjo	209	5	SARS	SARS	NNP
cord-329876-4cgrjnjo	209	6	-	-	HYPH
cord-329876-4cgrjnjo	209	7	CoV	CoV	NNP
cord-329876-4cgrjnjo	209	8	PL	pl	NN
cord-329876-4cgrjnjo	209	9	pro	pro	JJ
cord-329876-4cgrjnjo	209	10	(	(	-LRB-
cord-329876-4cgrjnjo	209	11	C112S)-Ub	c112s)-ub	NN
cord-329876-4cgrjnjo	209	12	complex	complex	JJ
cord-329876-4cgrjnjo	210	1	(	(	-LRB-
cord-329876-4cgrjnjo	210	2	Chou	Chou	NNP
cord-329876-4cgrjnjo	210	3	et	et	NNP
cord-329876-4cgrjnjo	210	4	al	al	NNP
cord-329876-4cgrjnjo	210	5	.	.	NNP
cord-329876-4cgrjnjo	210	6	,	,	,
cord-329876-4cgrjnjo	210	7	2014	2014	CD
cord-329876-4cgrjnjo	210	8	)	)	-RRB-
cord-329876-4cgrjnjo	210	9	,	,	,
cord-329876-4cgrjnjo	210	10	the	the	DT
cord-329876-4cgrjnjo	210	11	side	side	NN
cord-329876-4cgrjnjo	210	12	-	-	HYPH
cord-329876-4cgrjnjo	210	13	chain	chain	NN
cord-329876-4cgrjnjo	210	14	of	of	IN
cord-329876-4cgrjnjo	210	15	Arg74	Arg74	NNP
cord-329876-4cgrjnjo	210	16	forms	form	VBZ
cord-329876-4cgrjnjo	210	17	a	a	DT
cord-329876-4cgrjnjo	210	18	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	210	19	bond	bond	NN
cord-329876-4cgrjnjo	210	20	with	with	IN
cord-329876-4cgrjnjo	210	21	the	the	DT
cord-329876-4cgrjnjo	210	22	main	main	JJ
cord-329876-4cgrjnjo	210	23	-	-	HYPH
cord-329876-4cgrjnjo	210	24	chain	chain	NN
cord-329876-4cgrjnjo	210	25	carbonyl	carbonyl	NN
cord-329876-4cgrjnjo	210	26	oxygen	oxygen	NN
cord-329876-4cgrjnjo	210	27	of	of	IN
cord-329876-4cgrjnjo	210	28	Gln270	gln270	CD
cord-329876-4cgrjnjo	210	29	.	.	.
cord-329876-4cgrjnjo	211	1	Instead	instead	RB
cord-329876-4cgrjnjo	211	2	,	,	,
cord-329876-4cgrjnjo	211	3	Arg74	Arg74	NNP
cord-329876-4cgrjnjo	211	4	is	be	VBZ
cord-329876-4cgrjnjo	211	5	involved	involve	VBN
cord-329876-4cgrjnjo	211	6	in	in	IN
cord-329876-4cgrjnjo	211	7	a	a	DT
cord-329876-4cgrjnjo	211	8	relatively	relatively	RB
cord-329876-4cgrjnjo	211	9	weak	weak	JJ
cord-329876-4cgrjnjo	211	10	salt	salt	NN
cord-329876-4cgrjnjo	211	11	-	-	HYPH
cord-329876-4cgrjnjo	211	12	bridge	bridge	NN
cord-329876-4cgrjnjo	211	13	with	with	IN
cord-329876-4cgrjnjo	211	14	Glu162	Glu162	,
cord-329876-4cgrjnjo	211	15	in	in	IN
cord-329876-4cgrjnjo	211	16	the	the	DT
cord-329876-4cgrjnjo	211	17	SARS	SARS	NNP
cord-329876-4cgrjnjo	211	18	-	-	HYPH
cord-329876-4cgrjnjo	211	19	CoV	CoV	NNP
cord-329876-4cgrjnjo	211	20	PL	pl	NN
cord-329876-4cgrjnjo	211	21	pro	pro	JJ
cord-329876-4cgrjnjo	211	22	(	(	-LRB-
cord-329876-4cgrjnjo	211	23	C112S)-Ub	c112s)-ub	NN
cord-329876-4cgrjnjo	211	24	complex	complex	JJ
cord-329876-4cgrjnjo	212	1	(	(	-LRB-
cord-329876-4cgrjnjo	212	2	Chou	Chou	NNP
cord-329876-4cgrjnjo	212	3	et	et	NNP
cord-329876-4cgrjnjo	212	4	al	al	NNP
cord-329876-4cgrjnjo	212	5	.	.	NNP
cord-329876-4cgrjnjo	212	6	,	,	,
cord-329876-4cgrjnjo	212	7	2014	2014	CD
cord-329876-4cgrjnjo	212	8	)	)	-RRB-
cord-329876-4cgrjnjo	212	9	.	.	.
cord-329876-4cgrjnjo	213	1	None	none	NN
cord-329876-4cgrjnjo	213	2	of	of	IN
cord-329876-4cgrjnjo	213	3	these	these	DT
cord-329876-4cgrjnjo	213	4	interactions	interaction	NNS
cord-329876-4cgrjnjo	213	5	exist	exist	VBP
cord-329876-4cgrjnjo	213	6	in	in	IN
cord-329876-4cgrjnjo	213	7	our	-PRON-	PRP$
cord-329876-4cgrjnjo	213	8	MERS	MERS	NNP
cord-329876-4cgrjnjo	213	9	-	-	HYPH
cord-329876-4cgrjnjo	213	10	CoV	cov	NN
cord-329876-4cgrjnjo	213	11	PL	pl	NN
cord-329876-4cgrjnjo	213	12	pro	pro	JJ
cord-329876-4cgrjnjo	213	13	-Ub	-ub	NN
cord-329876-4cgrjnjo	213	14	complex	complex	JJ
cord-329876-4cgrjnjo	213	15	.	.	.
cord-329876-4cgrjnjo	214	1	S4	S4	NNP
cord-329876-4cgrjnjo	214	2	subsite	subsite	NN
cord-329876-4cgrjnjo	214	3	.	.	.
cord-329876-4cgrjnjo	215	1	The	the	DT
cord-329876-4cgrjnjo	215	2	main	main	JJ
cord-329876-4cgrjnjo	215	3	-	-	HYPH
cord-329876-4cgrjnjo	215	4	chain	chain	NN
cord-329876-4cgrjnjo	215	5	amide	amide	NN
cord-329876-4cgrjnjo	215	6	of	of	IN
cord-329876-4cgrjnjo	215	7	Leu73	Leu73	NNP
cord-329876-4cgrjnjo	215	8	(	(	-LRB-
cord-329876-4cgrjnjo	215	9	P4	P4	NNP
cord-329876-4cgrjnjo	215	10	)	)	-RRB-
cord-329876-4cgrjnjo	215	11	donates	donate	VBZ
cord-329876-4cgrjnjo	215	12	a	a	DT
cord-329876-4cgrjnjo	215	13	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	215	14	bond	bond	NN
cord-329876-4cgrjnjo	215	15	to	to	IN
cord-329876-4cgrjnjo	215	16	the	the	DT
cord-329876-4cgrjnjo	215	17	side	side	NN
cord-329876-4cgrjnjo	215	18	-	-	HYPH
cord-329876-4cgrjnjo	215	19	chain	chain	NN
cord-329876-4cgrjnjo	215	20	of	of	IN
cord-329876-4cgrjnjo	216	1	Asp165	Asp165	NFP
cord-329876-4cgrjnjo	216	2	(	(	-LRB-
cord-329876-4cgrjnjo	216	3	region	region	NN
cord-329876-4cgrjnjo	216	4	II	ii	CD
cord-329876-4cgrjnjo	216	5	)	)	-RRB-
cord-329876-4cgrjnjo	217	1	(	(	-LRB-
cord-329876-4cgrjnjo	217	2	Figure	figure	NN
cord-329876-4cgrjnjo	217	3	3	3	CD
cord-329876-4cgrjnjo	217	4	)	)	-RRB-
cord-329876-4cgrjnjo	217	5	.	.	.
cord-329876-4cgrjnjo	218	1	This	this	DT
cord-329876-4cgrjnjo	218	2	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	218	3	bond	bond	NN
cord-329876-4cgrjnjo	218	4	is	be	VBZ
cord-329876-4cgrjnjo	218	5	conserved	conserve	VBN
cord-329876-4cgrjnjo	218	6	in	in	IN
cord-329876-4cgrjnjo	218	7	all	all	PDT
cord-329876-4cgrjnjo	218	8	the	the	DT
cord-329876-4cgrjnjo	218	9	complexes	complex	NNS
cord-329876-4cgrjnjo	218	10	compared	compare	VBN
cord-329876-4cgrjnjo	218	11	here	here	RB
cord-329876-4cgrjnjo	218	12	.	.	.
cord-329876-4cgrjnjo	219	1	In	in	IN
cord-329876-4cgrjnjo	219	2	our	-PRON-	PRP$
cord-329876-4cgrjnjo	219	3	peptide	peptide	NN
cord-329876-4cgrjnjo	219	4	-	-	HYPH
cord-329876-4cgrjnjo	219	5	cleavage	cleavage	NN
cord-329876-4cgrjnjo	219	6	assay	assay	NN
cord-329876-4cgrjnjo	219	7	,	,	,
cord-329876-4cgrjnjo	219	8	the	the	DT
cord-329876-4cgrjnjo	219	9	D165A	d165a	NN
cord-329876-4cgrjnjo	219	10	variant	variant	NN
cord-329876-4cgrjnjo	219	11	shows	show	VBZ
cord-329876-4cgrjnjo	219	12	about	about	IN
cord-329876-4cgrjnjo	219	13	16-fold	16-fold	CD
cord-329876-4cgrjnjo	219	14	and	and	CC
cord-329876-4cgrjnjo	219	15	10-fold	10-fold	JJ
cord-329876-4cgrjnjo	219	16	lower	low	JJR
cord-329876-4cgrjnjo	219	17	activities	activity	NNS
cord-329876-4cgrjnjo	219	18	towards	towards	IN
cord-329876-4cgrjnjo	219	19	substrates	substrate	NNS
cord-329876-4cgrjnjo	219	20	Z	z	NN
cord-329876-4cgrjnjo	219	21	-	-	HYPH
cord-329876-4cgrjnjo	219	22	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	219	23	-	-	HYPH
cord-329876-4cgrjnjo	219	24	AMC	AMC	NNP
cord-329876-4cgrjnjo	219	25	and	and	CC
cord-329876-4cgrjnjo	219	26	Z	Z	NNP
cord-329876-4cgrjnjo	219	27	-	-	HYPH
cord-329876-4cgrjnjo	219	28	LRGG	LRGG	NNP
cord-329876-4cgrjnjo	219	29	-	-	HYPH
cord-329876-4cgrjnjo	219	30	AMC	AMC	NNP
cord-329876-4cgrjnjo	219	31	,	,	,
cord-329876-4cgrjnjo	219	32	respectively	respectively	RB
cord-329876-4cgrjnjo	219	33	,	,	,
cord-329876-4cgrjnjo	219	34	indicating	indicate	VBG
cord-329876-4cgrjnjo	219	35	that	that	IN
cord-329876-4cgrjnjo	219	36	Asp165	Asp165	NFP
cord-329876-4cgrjnjo	219	37	is	be	VBZ
cord-329876-4cgrjnjo	219	38	not	not	RB
cord-329876-4cgrjnjo	219	39	only	only	RB
cord-329876-4cgrjnjo	219	40	important	important	JJ
cord-329876-4cgrjnjo	219	41	for	for	IN
cord-329876-4cgrjnjo	219	42	interacting	interact	VBG
cord-329876-4cgrjnjo	219	43	with	with	IN
cord-329876-4cgrjnjo	219	44	Arg42	Arg42	NNP
cord-329876-4cgrjnjo	219	45	of	of	IN
cord-329876-4cgrjnjo	219	46	Ub	Ub	NNP
cord-329876-4cgrjnjo	219	47	(	(	-LRB-
cord-329876-4cgrjnjo	219	48	see	see	VB
cord-329876-4cgrjnjo	219	49	above	above	RB
cord-329876-4cgrjnjo	219	50	)	)	-RRB-
cord-329876-4cgrjnjo	219	51	.	.	.
cord-329876-4cgrjnjo	220	1	The	the	DT
cord-329876-4cgrjnjo	220	2	side	side	NN
cord-329876-4cgrjnjo	220	3	-	-	HYPH
cord-329876-4cgrjnjo	220	4	chain	chain	NN
cord-329876-4cgrjnjo	220	5	of	of	IN
cord-329876-4cgrjnjo	220	6	Leu73	Leu73	NNP
cord-329876-4cgrjnjo	220	7	is	be	VBZ
cord-329876-4cgrjnjo	220	8	embedded	embed	VBN
cord-329876-4cgrjnjo	220	9	in	in	IN
cord-329876-4cgrjnjo	220	10	a	a	DT
cord-329876-4cgrjnjo	220	11	hydrophobic	hydrophobic	JJ
cord-329876-4cgrjnjo	220	12	pocket	pocket	NN
cord-329876-4cgrjnjo	220	13	which	which	WDT
cord-329876-4cgrjnjo	220	14	is	be	VBZ
cord-329876-4cgrjnjo	220	15	formed	form	VBN
cord-329876-4cgrjnjo	220	16	by	by	IN
cord-329876-4cgrjnjo	220	17	the	the	DT
cord-329876-4cgrjnjo	220	18	Cβ	Cβ	NNP
cord-329876-4cgrjnjo	220	19	atom	atom	NN
cord-329876-4cgrjnjo	220	20	of	of	IN
cord-329876-4cgrjnjo	220	21	Asp165	asp165	CD
cord-329876-4cgrjnjo	220	22	,	,	,
cord-329876-4cgrjnjo	220	23	the	the	DT
cord-329876-4cgrjnjo	220	24	side	side	NN
cord-329876-4cgrjnjo	220	25	-	-	HYPH
cord-329876-4cgrjnjo	220	26	chain	chain	NN
cord-329876-4cgrjnjo	220	27	of	of	IN
cord-329876-4cgrjnjo	220	28	Pro250	Pro250	NNP
cord-329876-4cgrjnjo	220	29	(	(	-LRB-
cord-329876-4cgrjnjo	220	30	region	region	NN
cord-329876-4cgrjnjo	220	31	IV	IV	NNP
cord-329876-4cgrjnjo	220	32	)	)	-RRB-
cord-329876-4cgrjnjo	220	33	,	,	,
cord-329876-4cgrjnjo	220	34	Phe269	phe269	CD
cord-329876-4cgrjnjo	220	35	,	,	,
cord-329876-4cgrjnjo	220	36	as	as	RB
cord-329876-4cgrjnjo	220	37	well	well	RB
cord-329876-4cgrjnjo	220	38	as	as	IN
cord-329876-4cgrjnjo	220	39	the	the	DT
cord-329876-4cgrjnjo	220	40	Cβ	Cβ	NNP
cord-329876-4cgrjnjo	220	41	and	and	CC
cord-329876-4cgrjnjo	220	42	Cγ	Cγ	NNP
cord-329876-4cgrjnjo	220	43	atoms	atom	NNS
cord-329876-4cgrjnjo	220	44	of	of	IN
cord-329876-4cgrjnjo	220	45	Glu273	Glu273	NNP
cord-329876-4cgrjnjo	220	46	(	(	-LRB-
cord-329876-4cgrjnjo	220	47	region	region	NN
cord-329876-4cgrjnjo	220	48	V	V	NNP
cord-329876-4cgrjnjo	220	49	)	)	-RRB-
cord-329876-4cgrjnjo	220	50	.	.	.
cord-329876-4cgrjnjo	221	1	Asp165	Asp165	NFP
cord-329876-4cgrjnjo	221	2	and	and	CC
cord-329876-4cgrjnjo	221	3	Pro250	Pro250	NNP
cord-329876-4cgrjnjo	221	4	are	be	VBP
cord-329876-4cgrjnjo	221	5	conserved	conserve	VBN
cord-329876-4cgrjnjo	221	6	in	in	IN
cord-329876-4cgrjnjo	221	7	SARS	SARS	NNP
cord-329876-4cgrjnjo	221	8	-	-	HYPH
cord-329876-4cgrjnjo	221	9	CoV	CoV	NNP
cord-329876-4cgrjnjo	221	10	PL	pl	NN
cord-329876-4cgrjnjo	221	11	pro	pro	NNP
cord-329876-4cgrjnjo	221	12	(	(	-LRB-
cord-329876-4cgrjnjo	221	13	Asp165	Asp165	NFP
cord-329876-4cgrjnjo	221	14	and	and	CC
cord-329876-4cgrjnjo	221	15	Pro249	pro249	CD
cord-329876-4cgrjnjo	221	16	)	)	-RRB-
cord-329876-4cgrjnjo	221	17	.	.	.
cord-329876-4cgrjnjo	222	1	Phe269	phe269	DT
cord-329876-4cgrjnjo	222	2	is	be	VBZ
cord-329876-4cgrjnjo	222	3	replaced	replace	VBN
cord-329876-4cgrjnjo	222	4	by	by	IN
cord-329876-4cgrjnjo	222	5	Tyr265	tyr265	CD
cord-329876-4cgrjnjo	222	6	,	,	,
cord-329876-4cgrjnjo	222	7	and	and	CC
cord-329876-4cgrjnjo	222	8	Glu273	Glu273	NNP
cord-329876-4cgrjnjo	222	9	,	,	,
cord-329876-4cgrjnjo	222	10	situated	situate	VBN
cord-329876-4cgrjnjo	222	11	in	in	IN
cord-329876-4cgrjnjo	222	12	the	the	DT
cord-329876-4cgrjnjo	222	13	BL2	bl2	NN
cord-329876-4cgrjnjo	222	14	loop	loop	NN
cord-329876-4cgrjnjo	222	15	,	,	,
cord-329876-4cgrjnjo	222	16	is	be	VBZ
cord-329876-4cgrjnjo	222	17	replaced	replace	VBN
cord-329876-4cgrjnjo	222	18	by	by	IN
cord-329876-4cgrjnjo	222	19	Tyr269	tyr269	CD
cord-329876-4cgrjnjo	222	20	.	.	.
cord-329876-4cgrjnjo	223	1	However	however	RB
cord-329876-4cgrjnjo	223	2	,	,	,
cord-329876-4cgrjnjo	223	3	the	the	DT
cord-329876-4cgrjnjo	223	4	side	side	NN
cord-329876-4cgrjnjo	223	5	-	-	HYPH
cord-329876-4cgrjnjo	223	6	chains	chain	NNS
cord-329876-4cgrjnjo	223	7	of	of	IN
cord-329876-4cgrjnjo	223	8	all	all	PDT
cord-329876-4cgrjnjo	223	9	these	these	DT
cord-329876-4cgrjnjo	223	10	non	non	JJ
cord-329876-4cgrjnjo	223	11	-	-	JJ
cord-329876-4cgrjnjo	223	12	conserved	conserved	JJ
cord-329876-4cgrjnjo	223	13	residues	residue	NNS
cord-329876-4cgrjnjo	223	14	possess	possess	VBP
cord-329876-4cgrjnjo	223	15	the	the	DT
cord-329876-4cgrjnjo	223	16	ability	ability	NN
cord-329876-4cgrjnjo	223	17	to	to	TO
cord-329876-4cgrjnjo	223	18	provide	provide	VB
cord-329876-4cgrjnjo	223	19	a	a	DT
cord-329876-4cgrjnjo	223	20	hydrophobic	hydrophobic	JJ
cord-329876-4cgrjnjo	223	21	environment	environment	NN
cord-329876-4cgrjnjo	223	22	to	to	TO
cord-329876-4cgrjnjo	223	23	accommodate	accommodate	VB
cord-329876-4cgrjnjo	223	24	Leu73	Leu73	NNP
cord-329876-4cgrjnjo	223	25	.	.	.
cord-329876-4cgrjnjo	223	26	S5	S5	NNP
cord-329876-4cgrjnjo	223	27	subsite	subsite	NN
cord-329876-4cgrjnjo	223	28	.	.	.
cord-329876-4cgrjnjo	224	1	The	the	DT
cord-329876-4cgrjnjo	224	2	side	side	NN
cord-329876-4cgrjnjo	224	3	-	-	HYPH
cord-329876-4cgrjnjo	224	4	chain	chain	NN
cord-329876-4cgrjnjo	224	5	of	of	IN
cord-329876-4cgrjnjo	224	6	Arg72	Arg72	NNP
cord-329876-4cgrjnjo	224	7	(	(	-LRB-
cord-329876-4cgrjnjo	224	8	P5	P5	NNP
cord-329876-4cgrjnjo	224	9	)	)	-RRB-
cord-329876-4cgrjnjo	224	10	is	be	VBZ
cord-329876-4cgrjnjo	224	11	located	locate	VBN
cord-329876-4cgrjnjo	224	12	between	between	IN
cord-329876-4cgrjnjo	224	13	the	the	DT
cord-329876-4cgrjnjo	224	14	PL	pl	NN
cord-329876-4cgrjnjo	224	15	pro	pro	JJ
cord-329876-4cgrjnjo	224	16	thumb	thumb	NN
cord-329876-4cgrjnjo	224	17	domain	domain	NN
cord-329876-4cgrjnjo	224	18	and	and	CC
cord-329876-4cgrjnjo	224	19	region	region	NN
cord-329876-4cgrjnjo	224	20	A	a	NN
cord-329876-4cgrjnjo	224	21	of	of	IN
cord-329876-4cgrjnjo	224	22	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	224	23	.	.	.
cord-329876-4cgrjnjo	225	1	It	-PRON-	PRP
cord-329876-4cgrjnjo	225	2	forms	form	VBZ
cord-329876-4cgrjnjo	225	3	a	a	DT
cord-329876-4cgrjnjo	225	4	salt	salt	NN
cord-329876-4cgrjnjo	225	5	-	-	HYPH
cord-329876-4cgrjnjo	225	6	bridge	bridge	NN
cord-329876-4cgrjnjo	225	7	with	with	IN
cord-329876-4cgrjnjo	225	8	the	the	DT
cord-329876-4cgrjnjo	225	9	side	side	NN
cord-329876-4cgrjnjo	225	10	-	-	HYPH
cord-329876-4cgrjnjo	225	11	chain	chain	NN
cord-329876-4cgrjnjo	225	12	of	of	IN
cord-329876-4cgrjnjo	225	13	Asp164	asp164	CD
cord-329876-4cgrjnjo	225	14	in	in	IN
cord-329876-4cgrjnjo	225	15	MERS	MERS	NNP
cord-329876-4cgrjnjo	225	16	-	-	HYPH
cord-329876-4cgrjnjo	225	17	CoV	CoV	NNP
cord-329876-4cgrjnjo	225	18	PL	pl	NN
cord-329876-4cgrjnjo	225	19	pro	pro	NNP
cord-329876-4cgrjnjo	225	20	.	.	.
cord-329876-4cgrjnjo	226	1	In	in	IN
cord-329876-4cgrjnjo	226	2	addition	addition	NN
cord-329876-4cgrjnjo	226	3	,	,	,
cord-329876-4cgrjnjo	226	4	the	the	DT
cord-329876-4cgrjnjo	226	5	guanidinum	guanidinum	NNP
cord-329876-4cgrjnjo	226	6	group	group	NN
cord-329876-4cgrjnjo	226	7	of	of	IN
cord-329876-4cgrjnjo	226	8	Arg72	Arg72	NNP
cord-329876-4cgrjnjo	226	9	may	may	MD
cord-329876-4cgrjnjo	226	10	be	be	VB
cord-329876-4cgrjnjo	226	11	involved	involve	VBN
cord-329876-4cgrjnjo	226	12	in	in	IN
cord-329876-4cgrjnjo	226	13	a	a	DT
cord-329876-4cgrjnjo	226	14	π	π	NN
cord-329876-4cgrjnjo	226	15	-	-	HYPH
cord-329876-4cgrjnjo	226	16	π	π	NN
cord-329876-4cgrjnjo	226	17	interaction	interaction	NN
cord-329876-4cgrjnjo	226	18	with	with	IN
cord-329876-4cgrjnjo	226	19	that	that	DT
cord-329876-4cgrjnjo	226	20	of	of	IN
cord-329876-4cgrjnjo	226	21	Arg168	Arg168	.
cord-329876-4cgrjnjo	226	22	(	(	-LRB-
cord-329876-4cgrjnjo	226	23	Figure	figure	NN
cord-329876-4cgrjnjo	226	24	3	3	CD
cord-329876-4cgrjnjo	226	25	)	)	-RRB-
cord-329876-4cgrjnjo	226	26	.	.	.
cord-329876-4cgrjnjo	227	1	These	these	DT
cord-329876-4cgrjnjo	227	2	interactions	interaction	NNS
cord-329876-4cgrjnjo	227	3	have	have	VBP
cord-329876-4cgrjnjo	227	4	also	also	RB
cord-329876-4cgrjnjo	227	5	been	be	VBN
cord-329876-4cgrjnjo	227	6	described	describe	VBN
cord-329876-4cgrjnjo	227	7	for	for	IN
cord-329876-4cgrjnjo	227	8	the	the	DT
cord-329876-4cgrjnjo	227	9	covalent	covalent	JJ
cord-329876-4cgrjnjo	227	10	complex	complex	NN
cord-329876-4cgrjnjo	227	11	of	of	IN
cord-329876-4cgrjnjo	227	12	MERS	MERS	NNP
cord-329876-4cgrjnjo	227	13	-	-	HYPH
cord-329876-4cgrjnjo	227	14	CoV	CoV	NNP
cord-329876-4cgrjnjo	227	15	PL	pl	NN
cord-329876-4cgrjnjo	227	16	pro	pro	JJ
cord-329876-4cgrjnjo	227	17	with	with	IN
cord-329876-4cgrjnjo	227	18	Ub	Ub	NNP
cord-329876-4cgrjnjo	227	19	(	(	-LRB-
cord-329876-4cgrjnjo	227	20	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	227	21	-	-	HYPH
cord-329876-4cgrjnjo	227	22	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	227	23	et	et	NNP
cord-329876-4cgrjnjo	227	24	al	al	NNP
cord-329876-4cgrjnjo	227	25	.	.	NNP
cord-329876-4cgrjnjo	227	26	,	,	,
cord-329876-4cgrjnjo	227	27	2014	2014	CD
cord-329876-4cgrjnjo	227	28	)	)	-RRB-
cord-329876-4cgrjnjo	227	29	.	.	.
cord-329876-4cgrjnjo	228	1	Arg72	Arg72	NNP
cord-329876-4cgrjnjo	228	2	is	be	VBZ
cord-329876-4cgrjnjo	228	3	not	not	RB
cord-329876-4cgrjnjo	228	4	subject	subject	JJ
cord-329876-4cgrjnjo	228	5	to	to	IN
cord-329876-4cgrjnjo	228	6	strict	strict	JJ
cord-329876-4cgrjnjo	228	7	space	space	NN
cord-329876-4cgrjnjo	228	8	limitations	limitation	NNS
cord-329876-4cgrjnjo	228	9	;	;	:
cord-329876-4cgrjnjo	228	10	accordingly	accordingly	RB
cord-329876-4cgrjnjo	228	11	,	,	,
cord-329876-4cgrjnjo	228	12	this	this	DT
cord-329876-4cgrjnjo	228	13	residue	residue	NN
cord-329876-4cgrjnjo	228	14	displays	display	VBZ
cord-329876-4cgrjnjo	228	15	different	different	JJ
cord-329876-4cgrjnjo	228	16	binding	bind	VBG
cord-329876-4cgrjnjo	228	17	patterns	pattern	NNS
cord-329876-4cgrjnjo	228	18	in	in	IN
cord-329876-4cgrjnjo	228	19	the	the	DT
cord-329876-4cgrjnjo	228	20	two	two	CD
cord-329876-4cgrjnjo	228	21	SARS	SARS	NNP
cord-329876-4cgrjnjo	228	22	-	-	HYPH
cord-329876-4cgrjnjo	228	23	CoV	cov	NN
cord-329876-4cgrjnjo	228	24	residues	residue	NNS
cord-329876-4cgrjnjo	228	25	are	be	VBP
cord-329876-4cgrjnjo	228	26	shown	show	VBN
cord-329876-4cgrjnjo	228	27	in	in	IN
cord-329876-4cgrjnjo	228	28	purple	purple	NN
cord-329876-4cgrjnjo	228	29	in	in	IN
cord-329876-4cgrjnjo	228	30	the	the	DT
cord-329876-4cgrjnjo	228	31	ball	ball	NN
cord-329876-4cgrjnjo	228	32	-	-	HYPH
cord-329876-4cgrjnjo	228	33	and	and	CC
cord-329876-4cgrjnjo	228	34	-	-	HYPH
cord-329876-4cgrjnjo	228	35	stick	stick	NN
cord-329876-4cgrjnjo	228	36	style	style	NN
cord-329876-4cgrjnjo	228	37	,	,	,
cord-329876-4cgrjnjo	228	38	and	and	CC
cord-329876-4cgrjnjo	228	39	they	-PRON-	PRP
cord-329876-4cgrjnjo	228	40	are	be	VBP
cord-329876-4cgrjnjo	228	41	labeled	label	VBN
cord-329876-4cgrjnjo	228	42	in	in	IN
cord-329876-4cgrjnjo	228	43	red	red	NN
cord-329876-4cgrjnjo	228	44	.	.	.
cord-329876-4cgrjnjo	229	1	For	for	IN
cord-329876-4cgrjnjo	229	2	clarity	clarity	NN
cord-329876-4cgrjnjo	229	3	,	,	,
cord-329876-4cgrjnjo	229	4	the	the	DT
cord-329876-4cgrjnjo	229	5	2F	2F	NNP
cord-329876-4cgrjnjo	229	6	o	o	NNP
cord-329876-4cgrjnjo	229	7	-F	-F	HYPH
cord-329876-4cgrjnjo	229	8	c	c	NN
cord-329876-4cgrjnjo	229	9	electron	electron	NN
cord-329876-4cgrjnjo	229	10	density	density	NN
cord-329876-4cgrjnjo	229	11	(	(	-LRB-
cord-329876-4cgrjnjo	229	12	blue	blue	NNP
cord-329876-4cgrjnjo	229	13	;	;	:
cord-329876-4cgrjnjo	229	14	1.0	1.0	CD
cord-329876-4cgrjnjo	229	15	σ	σ	NNP
cord-329876-4cgrjnjo	229	16	)	)	-RRB-
cord-329876-4cgrjnjo	229	17	of	of	IN
cord-329876-4cgrjnjo	229	18	the	the	DT
cord-329876-4cgrjnjo	229	19	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	229	20	main	main	JJ
cord-329876-4cgrjnjo	229	21	chain	chain	NN
cord-329876-4cgrjnjo	229	22	is	be	VBZ
cord-329876-4cgrjnjo	229	23	shown	show	VBN
cord-329876-4cgrjnjo	229	24	.	.	.
cord-329876-4cgrjnjo	230	1	PL	pl	NN
cord-329876-4cgrjnjo	230	2	pro	pro	JJ
cord-329876-4cgrjnjo	230	3	residues	residue	NNS
cord-329876-4cgrjnjo	230	4	are	be	VBP
cord-329876-4cgrjnjo	230	5	displayed	display	VBN
cord-329876-4cgrjnjo	230	6	in	in	IN
cord-329876-4cgrjnjo	230	7	green	green	NN
cord-329876-4cgrjnjo	230	8	in	in	IN
cord-329876-4cgrjnjo	230	9	the	the	DT
cord-329876-4cgrjnjo	230	10	balland	balland	JJ
cord-329876-4cgrjnjo	230	11	-	-	HYPH
cord-329876-4cgrjnjo	230	12	stick	stick	NN
cord-329876-4cgrjnjo	230	13	style	style	NN
cord-329876-4cgrjnjo	230	14	,	,	,
cord-329876-4cgrjnjo	230	15	and	and	CC
cord-329876-4cgrjnjo	230	16	they	-PRON-	PRP
cord-329876-4cgrjnjo	230	17	are	be	VBP
cord-329876-4cgrjnjo	230	18	labeled	label	VBN
cord-329876-4cgrjnjo	230	19	in	in	IN
cord-329876-4cgrjnjo	230	20	black	black	NN
cord-329876-4cgrjnjo	230	21	.	.	.
cord-329876-4cgrjnjo	231	1	Hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	231	2	bonds	bond	NNS
cord-329876-4cgrjnjo	231	3	are	be	VBP
cord-329876-4cgrjnjo	231	4	displayed	display	VBN
cord-329876-4cgrjnjo	231	5	as	as	IN
cord-329876-4cgrjnjo	231	6	black	black	JJ
cord-329876-4cgrjnjo	231	7	dashed	dash	VBN
cord-329876-4cgrjnjo	231	8	lines	line	NNS
cord-329876-4cgrjnjo	231	9	,	,	,
cord-329876-4cgrjnjo	231	10	and	and	CC
cord-329876-4cgrjnjo	231	11	the	the	DT
cord-329876-4cgrjnjo	231	12	salt	salt	NN
cord-329876-4cgrjnjo	231	13	-	-	HYPH
cord-329876-4cgrjnjo	231	14	bridge	bridge	NN
cord-329876-4cgrjnjo	231	15	between	between	IN
cord-329876-4cgrjnjo	231	16	R72	R72	NNP
cord-329876-4cgrjnjo	231	17	and	and	CC
cord-329876-4cgrjnjo	231	18	D164	D164	NNPS
cord-329876-4cgrjnjo	231	19	is	be	VBZ
cord-329876-4cgrjnjo	231	20	depicted	depict	VBN
cord-329876-4cgrjnjo	231	21	as	as	IN
cord-329876-4cgrjnjo	231	22	two	two	CD
cord-329876-4cgrjnjo	231	23	red	red	JJ
cord-329876-4cgrjnjo	231	24	dashed	dash	VBD
cord-329876-4cgrjnjo	231	25	lines	line	NNS
cord-329876-4cgrjnjo	231	26	.	.	.
cord-329876-4cgrjnjo	232	1	Structure	structure	NN
cord-329876-4cgrjnjo	232	2	of	of	IN
cord-329876-4cgrjnjo	232	3	MERS	MERS	NNP
cord-329876-4cgrjnjo	232	4	-	-	HYPH
cord-329876-4cgrjnjo	232	5	CoV	CoV	NNP
cord-329876-4cgrjnjo	232	6	PL	pl	NN
cord-329876-4cgrjnjo	232	7	pro	pro	JJ
cord-329876-4cgrjnjo	232	8	-ubiquitin	-ubiquitin	JJ
cord-329876-4cgrjnjo	232	9	complex	complex	JJ
cord-329876-4cgrjnjo	232	10	PL	pl	NN
cord-329876-4cgrjnjo	232	11	pro	pro	NN
cord-329876-4cgrjnjo	232	12	-Ub	-ub	NN
cord-329876-4cgrjnjo	232	13	complexes	complex	NNS
cord-329876-4cgrjnjo	232	14	.	.	.
cord-329876-4cgrjnjo	233	1	In	in	IN
cord-329876-4cgrjnjo	233	2	the	the	DT
cord-329876-4cgrjnjo	233	3	covalent	covalent	JJ
cord-329876-4cgrjnjo	233	4	SARS	SARS	NNP
cord-329876-4cgrjnjo	233	5	-	-	HYPH
cord-329876-4cgrjnjo	233	6	CoV	cov	NN
cord-329876-4cgrjnjo	233	7	PL	pl	NN
cord-329876-4cgrjnjo	233	8	pro	pro	NNP
cord-329876-4cgrjnjo	233	9	-Ubal	-Ubal	NNP
cord-329876-4cgrjnjo	233	10	complex	complex	JJ
cord-329876-4cgrjnjo	233	11	(	(	-LRB-
cord-329876-4cgrjnjo	233	12	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	233	13	et	et	NNP
cord-329876-4cgrjnjo	233	14	al	al	NNP
cord-329876-4cgrjnjo	233	15	.	.	NNP
cord-329876-4cgrjnjo	233	16	,	,	,
cord-329876-4cgrjnjo	233	17	2014	2014	CD
cord-329876-4cgrjnjo	233	18	)	)	-RRB-
cord-329876-4cgrjnjo	233	19	,	,	,
cord-329876-4cgrjnjo	233	20	Arg72	Arg72	NNP
cord-329876-4cgrjnjo	233	21	forms	form	VBZ
cord-329876-4cgrjnjo	233	22	a	a	DT
cord-329876-4cgrjnjo	233	23	saltbridge	saltbridge	NN
cord-329876-4cgrjnjo	233	24	with	with	IN
cord-329876-4cgrjnjo	233	25	Glu168	Glu168	NNS
cord-329876-4cgrjnjo	233	26	.	.	.
cord-329876-4cgrjnjo	234	1	In	in	IN
cord-329876-4cgrjnjo	234	2	the	the	DT
cord-329876-4cgrjnjo	234	3	non	non	JJ
cord-329876-4cgrjnjo	234	4	-	-	JJ
cord-329876-4cgrjnjo	234	5	covalent	covalent	JJ
cord-329876-4cgrjnjo	234	6	SARS	SARS	NNP
cord-329876-4cgrjnjo	234	7	-	-	HYPH
cord-329876-4cgrjnjo	234	8	CoV	cov	NN
cord-329876-4cgrjnjo	234	9	PL	pl	NN
cord-329876-4cgrjnjo	234	10	pro	pro	JJ
cord-329876-4cgrjnjo	234	11	(	(	-LRB-
cord-329876-4cgrjnjo	234	12	C112S)-Ub	c112s)-ub	NN
cord-329876-4cgrjnjo	234	13	complex	complex	NN
cord-329876-4cgrjnjo	234	14	(	(	-LRB-
cord-329876-4cgrjnjo	234	15	Chou	Chou	NNP
cord-329876-4cgrjnjo	234	16	et	et	NNP
cord-329876-4cgrjnjo	234	17	al	al	NNP
cord-329876-4cgrjnjo	234	18	.	.	NNP
cord-329876-4cgrjnjo	234	19	,	,	,
cord-329876-4cgrjnjo	234	20	2014	2014	CD
cord-329876-4cgrjnjo	234	21	)	)	-RRB-
cord-329876-4cgrjnjo	234	22	,	,	,
cord-329876-4cgrjnjo	234	23	Arg72	Arg72	NNP
cord-329876-4cgrjnjo	234	24	is	be	VBZ
cord-329876-4cgrjnjo	234	25	exposed	expose	VBN
cord-329876-4cgrjnjo	234	26	to	to	IN
cord-329876-4cgrjnjo	234	27	the	the	DT
cord-329876-4cgrjnjo	234	28	solvent	solvent	NN
cord-329876-4cgrjnjo	234	29	and	and	CC
cord-329876-4cgrjnjo	234	30	does	do	VBZ
cord-329876-4cgrjnjo	234	31	not	not	RB
cord-329876-4cgrjnjo	234	32	interact	interact	VB
cord-329876-4cgrjnjo	234	33	with	with	IN
cord-329876-4cgrjnjo	234	34	Glu168	glu168	ADD
cord-329876-4cgrjnjo	235	1	(	(	-LRB-
cord-329876-4cgrjnjo	235	2	Arg42	Arg42	NNP
cord-329876-4cgrjnjo	235	3	instead	instead	RB
cord-329876-4cgrjnjo	235	4	forms	form	VBZ
cord-329876-4cgrjnjo	235	5	a	a	DT
cord-329876-4cgrjnjo	235	6	salt	salt	NN
cord-329876-4cgrjnjo	235	7	-	-	HYPH
cord-329876-4cgrjnjo	235	8	bridge	bridge	NN
cord-329876-4cgrjnjo	235	9	with	with	IN
cord-329876-4cgrjnjo	235	10	Glu168	Glu168	NNP
cord-329876-4cgrjnjo	235	11	,	,	,
cord-329876-4cgrjnjo	235	12	as	as	IN
cord-329876-4cgrjnjo	235	13	mentioned	mention	VBN
cord-329876-4cgrjnjo	235	14	above	above	RB
cord-329876-4cgrjnjo	235	15	)	)	-RRB-
cord-329876-4cgrjnjo	235	16	.	.	.
cord-329876-4cgrjnjo	236	1	In	in	IN
cord-329876-4cgrjnjo	236	2	our	-PRON-	PRP$
cord-329876-4cgrjnjo	236	3	kinetic	kinetic	JJ
cord-329876-4cgrjnjo	236	4	assay	assay	NN
cord-329876-4cgrjnjo	236	5	,	,	,
cord-329876-4cgrjnjo	236	6	the	the	DT
cord-329876-4cgrjnjo	236	7	D164A	D164A	NNPS
cord-329876-4cgrjnjo	236	8	variant	variant	NN
cord-329876-4cgrjnjo	236	9	of	of	IN
cord-329876-4cgrjnjo	236	10	MERS	MERS	NNP
cord-329876-4cgrjnjo	236	11	-	-	HYPH
cord-329876-4cgrjnjo	236	12	CoV	CoV	NNP
cord-329876-4cgrjnjo	236	13	PL	pl	NN
cord-329876-4cgrjnjo	236	14	pro	pro	NNP
cord-329876-4cgrjnjo	236	15	displays	display	VBZ
cord-329876-4cgrjnjo	236	16	a	a	DT
cord-329876-4cgrjnjo	236	17	~4.5-fold	~4.5-fold	NN
cord-329876-4cgrjnjo	236	18	and	and	CC
cord-329876-4cgrjnjo	236	19	a	a	DT
cord-329876-4cgrjnjo	236	20	~3.5-fold	~3.5-fold	JJ
cord-329876-4cgrjnjo	236	21	reduced	reduce	VBN
cord-329876-4cgrjnjo	236	22	activity	activity	NN
cord-329876-4cgrjnjo	236	23	,	,	,
cord-329876-4cgrjnjo	236	24	respectively	respectively	RB
cord-329876-4cgrjnjo	236	25	,	,	,
cord-329876-4cgrjnjo	236	26	for	for	IN
cord-329876-4cgrjnjo	236	27	Z	z	NN
cord-329876-4cgrjnjo	236	28	-	-	HYPH
cord-329876-4cgrjnjo	236	29	RLRGG	RLRGG	NNP
cord-329876-4cgrjnjo	236	30	-	-	HYPH
cord-329876-4cgrjnjo	236	31	AMC	AMC	NNP
cord-329876-4cgrjnjo	236	32	and	and	CC
cord-329876-4cgrjnjo	236	33	Ub	Ub	NNP
cord-329876-4cgrjnjo	236	34	-	-	HYPH
cord-329876-4cgrjnjo	236	35	AMC	AMC	NNP
cord-329876-4cgrjnjo	236	36	(	(	-LRB-
cord-329876-4cgrjnjo	236	37	Table	Table	NNP
cord-329876-4cgrjnjo	236	38	2	2	CD
cord-329876-4cgrjnjo	236	39	)	)	-RRB-
cord-329876-4cgrjnjo	236	40	.	.	.
cord-329876-4cgrjnjo	237	1	For	for	IN
cord-329876-4cgrjnjo	237	2	Z	z	NN
cord-329876-4cgrjnjo	237	3	-	-	HYPH
cord-329876-4cgrjnjo	237	4	LRGG	LRGG	NNP
cord-329876-4cgrjnjo	237	5	-	-	HYPH
cord-329876-4cgrjnjo	237	6	AMC	AMC	NNP
cord-329876-4cgrjnjo	237	7	,	,	,
cord-329876-4cgrjnjo	237	8	the	the	DT
cord-329876-4cgrjnjo	237	9	activity	activity	NN
cord-329876-4cgrjnjo	237	10	is	be	VBZ
cord-329876-4cgrjnjo	237	11	decreased	decrease	VBN
cord-329876-4cgrjnjo	237	12	just	just	RB
cord-329876-4cgrjnjo	237	13	a	a	DT
cord-329876-4cgrjnjo	237	14	little	little	JJ
cord-329876-4cgrjnjo	237	15	(	(	-LRB-
cord-329876-4cgrjnjo	237	16	by	by	IN
cord-329876-4cgrjnjo	237	17	about	about	IN
cord-329876-4cgrjnjo	237	18	~1.5-fold	~1.5-fold	CD
cord-329876-4cgrjnjo	237	19	)	)	-RRB-
cord-329876-4cgrjnjo	237	20	,	,	,
cord-329876-4cgrjnjo	237	21	because	because	IN
cord-329876-4cgrjnjo	237	22	there	there	EX
cord-329876-4cgrjnjo	237	23	is	be	VBZ
cord-329876-4cgrjnjo	237	24	no	no	DT
cord-329876-4cgrjnjo	237	25	P5-Arg	p5-arg	NN
cord-329876-4cgrjnjo	237	26	in	in	IN
cord-329876-4cgrjnjo	237	27	this	this	DT
cord-329876-4cgrjnjo	237	28	substrate	substrate	NN
cord-329876-4cgrjnjo	237	29	(	(	-LRB-
cord-329876-4cgrjnjo	237	30	Table	table	NN
cord-329876-4cgrjnjo	237	31	2	2	CD
cord-329876-4cgrjnjo	237	32	)	)	-RRB-
cord-329876-4cgrjnjo	237	33	.	.	.
cord-329876-4cgrjnjo	238	1	These	these	DT
cord-329876-4cgrjnjo	238	2	data	datum	NNS
cord-329876-4cgrjnjo	238	3	demonstrate	demonstrate	VBP
cord-329876-4cgrjnjo	238	4	that	that	IN
cord-329876-4cgrjnjo	238	5	Asp164	asp164	CD
cord-329876-4cgrjnjo	238	6	is	be	VBZ
cord-329876-4cgrjnjo	238	7	important	important	JJ
cord-329876-4cgrjnjo	238	8	for	for	IN
cord-329876-4cgrjnjo	238	9	the	the	DT
cord-329876-4cgrjnjo	238	10	interaction	interaction	NN
cord-329876-4cgrjnjo	238	11	with	with	IN
cord-329876-4cgrjnjo	238	12	Arg72	Arg72	NNP
cord-329876-4cgrjnjo	238	13	.	.	.
cord-329876-4cgrjnjo	239	1	In	in	IN
cord-329876-4cgrjnjo	239	2	summary	summary	NN
cord-329876-4cgrjnjo	239	3	,	,	,
cord-329876-4cgrjnjo	239	4	the	the	DT
cord-329876-4cgrjnjo	239	5	main	main	JJ
cord-329876-4cgrjnjo	239	6	-	-	HYPH
cord-329876-4cgrjnjo	239	7	chain	chain	NN
cord-329876-4cgrjnjo	239	8	heteroatoms	heteroatom	NNS
cord-329876-4cgrjnjo	239	9	of	of	IN
cord-329876-4cgrjnjo	239	10	P5-P1	P5-P1	NNP
cord-329876-4cgrjnjo	239	11	form	form	VBP
cord-329876-4cgrjnjo	239	12	a	a	DT
cord-329876-4cgrjnjo	239	13	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	239	14	-	-	HYPH
cord-329876-4cgrjnjo	239	15	bonding	bonding	NN
cord-329876-4cgrjnjo	239	16	network	network	NN
cord-329876-4cgrjnjo	239	17	with	with	IN
cord-329876-4cgrjnjo	239	18	PL	PL	NNP
cord-329876-4cgrjnjo	239	19	pro	pro	NNP
cord-329876-4cgrjnjo	239	20	.	.	.
cord-329876-4cgrjnjo	240	1	The	the	DT
cord-329876-4cgrjnjo	240	2	binding	bind	VBG
cord-329876-4cgrjnjo	240	3	characteristics	characteristic	NNS
cord-329876-4cgrjnjo	240	4	of	of	IN
cord-329876-4cgrjnjo	240	5	P1	P1	NNP
cord-329876-4cgrjnjo	240	6	,	,	,
cord-329876-4cgrjnjo	240	7	P2	P2	NNP
cord-329876-4cgrjnjo	240	8	,	,	,
cord-329876-4cgrjnjo	240	9	and	and	CC
cord-329876-4cgrjnjo	240	10	P4	p4	NN
cord-329876-4cgrjnjo	240	11	are	be	VBP
cord-329876-4cgrjnjo	240	12	conserved	conserve	VBN
cord-329876-4cgrjnjo	240	13	in	in	IN
cord-329876-4cgrjnjo	240	14	all	all	DT
cord-329876-4cgrjnjo	240	15	MERS	MERS	NNP
cord-329876-4cgrjnjo	240	16	-	-	HYPH
cord-329876-4cgrjnjo	240	17	CoV	CoV	NNP
cord-329876-4cgrjnjo	240	18	and	and	CC
cord-329876-4cgrjnjo	240	19	SARS	SARS	NNP
cord-329876-4cgrjnjo	240	20	-	-	HYPH
cord-329876-4cgrjnjo	240	21	CoV	CoV	NNP
cord-329876-4cgrjnjo	240	22	PL	pl	NN
cord-329876-4cgrjnjo	240	23	pro	pro	JJ
cord-329876-4cgrjnjo	240	24	-Ub	-ub	NN
cord-329876-4cgrjnjo	240	25	complexes	complex	NNS
cord-329876-4cgrjnjo	240	26	.	.	.
cord-329876-4cgrjnjo	241	1	However	however	RB
cord-329876-4cgrjnjo	241	2	,	,	,
cord-329876-4cgrjnjo	241	3	P3-Arg	P3-Arg	NNP
cord-329876-4cgrjnjo	241	4	and	and	CC
cord-329876-4cgrjnjo	241	5	P5-Arg	P5-Arg	NNP
cord-329876-4cgrjnjo	241	6	assume	assume	VB
cord-329876-4cgrjnjo	241	7	binding	bind	VBG
cord-329876-4cgrjnjo	241	8	patterns	pattern	NNS
cord-329876-4cgrjnjo	241	9	that	that	WDT
cord-329876-4cgrjnjo	241	10	differ	differ	VBP
cord-329876-4cgrjnjo	241	11	between	between	IN
cord-329876-4cgrjnjo	241	12	the	the	DT
cord-329876-4cgrjnjo	241	13	various	various	JJ
cord-329876-4cgrjnjo	241	14	MERS	MERS	NNP
cord-329876-4cgrjnjo	241	15	-	-	HYPH
cord-329876-4cgrjnjo	241	16	CoV	CoV	NNP
cord-329876-4cgrjnjo	241	17	and	and	CC
cord-329876-4cgrjnjo	241	18	SARS	SARS	NNP
cord-329876-4cgrjnjo	241	19	-	-	HYPH
cord-329876-4cgrjnjo	241	20	CoV	CoV	NNP
cord-329876-4cgrjnjo	241	21	PL	pl	NN
cord-329876-4cgrjnjo	241	22	pro	pro	JJ
cord-329876-4cgrjnjo	241	23	-Ub	-ub	NN
cord-329876-4cgrjnjo	241	24	complexes	complex	NNS
cord-329876-4cgrjnjo	241	25	.	.	.
cord-329876-4cgrjnjo	242	1	Viral	viral	JJ
cord-329876-4cgrjnjo	242	2	proteins	protein	NNS
cord-329876-4cgrjnjo	242	3	are	be	VBP
cord-329876-4cgrjnjo	242	4	likely	likely	JJ
cord-329876-4cgrjnjo	242	5	to	to	TO
cord-329876-4cgrjnjo	242	6	possess	possess	VB
cord-329876-4cgrjnjo	242	7	multiple	multiple	JJ
cord-329876-4cgrjnjo	242	8	functions	function	NNS
cord-329876-4cgrjnjo	242	9	,	,	,
cord-329876-4cgrjnjo	242	10	as	as	IN
cord-329876-4cgrjnjo	242	11	exemplified	exemplify	VBN
cord-329876-4cgrjnjo	242	12	by	by	IN
cord-329876-4cgrjnjo	242	13	non	non	JJ
cord-329876-4cgrjnjo	242	14	-	-	JJ
cord-329876-4cgrjnjo	242	15	structural	structural	JJ
cord-329876-4cgrjnjo	242	16	protein	protein	NN
cord-329876-4cgrjnjo	242	17	1	1	CD
cord-329876-4cgrjnjo	242	18	(	(	-LRB-
cord-329876-4cgrjnjo	242	19	NS1	ns1	NN
cord-329876-4cgrjnjo	242	20	)	)	-RRB-
cord-329876-4cgrjnjo	242	21	of	of	IN
cord-329876-4cgrjnjo	242	22	influenza	influenza	NN
cord-329876-4cgrjnjo	242	23	A	a	DT
cord-329876-4cgrjnjo	242	24	viruses	virus	NNS
cord-329876-4cgrjnjo	242	25	(	(	-LRB-
cord-329876-4cgrjnjo	242	26	Hale	Hale	NNP
cord-329876-4cgrjnjo	242	27	et	et	NNP
cord-329876-4cgrjnjo	242	28	al	al	NNP
cord-329876-4cgrjnjo	242	29	.	.	NNP
cord-329876-4cgrjnjo	242	30	,	,	,
cord-329876-4cgrjnjo	242	31	2008	2008	CD
cord-329876-4cgrjnjo	242	32	)	)	-RRB-
cord-329876-4cgrjnjo	242	33	,	,	,
cord-329876-4cgrjnjo	242	34	the	the	DT
cord-329876-4cgrjnjo	242	35	nucleocapsid	nucleocapsid	NN
cord-329876-4cgrjnjo	242	36	(	(	-LRB-
cord-329876-4cgrjnjo	242	37	N	N	NNP
cord-329876-4cgrjnjo	242	38	)	)	-RRB-
cord-329876-4cgrjnjo	242	39	protein	protein	NN
cord-329876-4cgrjnjo	242	40	of	of	IN
cord-329876-4cgrjnjo	242	41	coronaviruses	coronaviruse	NNS
cord-329876-4cgrjnjo	243	1	(	(	-LRB-
cord-329876-4cgrjnjo	243	2	Chang	Chang	NNP
cord-329876-4cgrjnjo	243	3	et	et	NNP
cord-329876-4cgrjnjo	243	4	al	al	NNP
cord-329876-4cgrjnjo	243	5	.	.	NNP
cord-329876-4cgrjnjo	243	6	,	,	,
cord-329876-4cgrjnjo	243	7	2014	2014	CD
cord-329876-4cgrjnjo	243	8	)	)	-RRB-
cord-329876-4cgrjnjo	243	9	,	,	,
cord-329876-4cgrjnjo	243	10	or	or	CC
cord-329876-4cgrjnjo	243	11	the	the	DT
cord-329876-4cgrjnjo	243	12	Nsp14	Nsp14	NNP
cord-329876-4cgrjnjo	243	13	exonuclease	exonuclease	NN
cord-329876-4cgrjnjo	243	14	-	-	HYPH
cord-329876-4cgrjnjo	243	15	guanyl-7-methyltransferase	guanyl-7-methyltransferase	NNP
cord-329876-4cgrjnjo	243	16	of	of	IN
cord-329876-4cgrjnjo	243	17	coronaviruses	coronaviruse	NNS
cord-329876-4cgrjnjo	244	1	(	(	-LRB-
cord-329876-4cgrjnjo	244	2	Chen	Chen	NNP
cord-329876-4cgrjnjo	244	3	et	et	NNP
cord-329876-4cgrjnjo	244	4	al	al	NNP
cord-329876-4cgrjnjo	244	5	.	.	NNP
cord-329876-4cgrjnjo	244	6	,	,	,
cord-329876-4cgrjnjo	244	7	2009	2009	CD
cord-329876-4cgrjnjo	244	8	)	)	-RRB-
cord-329876-4cgrjnjo	244	9	.	.	.
cord-329876-4cgrjnjo	245	1	Exhibiting	exhibit	VBG
cord-329876-4cgrjnjo	245	2	DUB	dub	NN
cord-329876-4cgrjnjo	245	3	and	and	CC
cord-329876-4cgrjnjo	245	4	proteolytic	proteolytic	JJ
cord-329876-4cgrjnjo	245	5	activities	activity	NNS
cord-329876-4cgrjnjo	245	6	,	,	,
cord-329876-4cgrjnjo	245	7	the	the	DT
cord-329876-4cgrjnjo	245	8	papain	papain	NN
cord-329876-4cgrjnjo	245	9	-	-	HYPH
cord-329876-4cgrjnjo	245	10	like	like	JJ
cord-329876-4cgrjnjo	245	11	proteases	protease	NNS
cord-329876-4cgrjnjo	245	12	of	of	IN
cord-329876-4cgrjnjo	245	13	coronaviruses	coronaviruse	NNS
cord-329876-4cgrjnjo	245	14	are	be	VBP
cord-329876-4cgrjnjo	245	15	no	no	DT
cord-329876-4cgrjnjo	245	16	exception	exception	NN
cord-329876-4cgrjnjo	245	17	here	here	RB
cord-329876-4cgrjnjo	245	18	.	.	.
cord-329876-4cgrjnjo	246	1	Although	although	IN
cord-329876-4cgrjnjo	246	2	the	the	DT
cord-329876-4cgrjnjo	246	3	overall	overall	JJ
cord-329876-4cgrjnjo	246	4	folds	fold	NNS
cord-329876-4cgrjnjo	246	5	are	be	VBP
cord-329876-4cgrjnjo	246	6	conserved	conserve	VBN
cord-329876-4cgrjnjo	246	7	,	,	,
cord-329876-4cgrjnjo	246	8	the	the	DT
cord-329876-4cgrjnjo	246	9	enzyme	enzyme	NN
cord-329876-4cgrjnjo	246	10	activity	activity	NN
cord-329876-4cgrjnjo	246	11	and	and	CC
cord-329876-4cgrjnjo	246	12	substrate	substrate	NN
cord-329876-4cgrjnjo	246	13	-	-	HYPH
cord-329876-4cgrjnjo	246	14	binding	bind	VBG
cord-329876-4cgrjnjo	246	15	modes	mode	NNS
cord-329876-4cgrjnjo	246	16	of	of	IN
cord-329876-4cgrjnjo	246	17	CoV	cov	NN
cord-329876-4cgrjnjo	246	18	PL	PL	NNP
cord-329876-4cgrjnjo	246	19	pro	pro	NNP
cord-329876-4cgrjnjo	246	20	s	s	NNP
cord-329876-4cgrjnjo	246	21	differ	differ	NN
cord-329876-4cgrjnjo	246	22	in	in	IN
cord-329876-4cgrjnjo	246	23	detail	detail	NN
cord-329876-4cgrjnjo	246	24	.	.	.
cord-329876-4cgrjnjo	247	1	Therefore	therefore	RB
cord-329876-4cgrjnjo	247	2	,	,	,
cord-329876-4cgrjnjo	247	3	no	no	DT
cord-329876-4cgrjnjo	247	4	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	247	5	PL	pl	NN
cord-329876-4cgrjnjo	247	6	pro	pro	NN
cord-329876-4cgrjnjo	247	7	can	can	MD
cord-329876-4cgrjnjo	247	8	be	be	VB
cord-329876-4cgrjnjo	247	9	considered	consider	VBN
cord-329876-4cgrjnjo	247	10	a	a	DT
cord-329876-4cgrjnjo	247	11	general	general	JJ
cord-329876-4cgrjnjo	247	12	model	model	NN
cord-329876-4cgrjnjo	247	13	for	for	IN
cord-329876-4cgrjnjo	247	14	all	all	PDT
cord-329876-4cgrjnjo	247	15	its	-PRON-	PRP$
cord-329876-4cgrjnjo	247	16	homologues	homologue	NNS
cord-329876-4cgrjnjo	247	17	(	(	-LRB-
cord-329876-4cgrjnjo	247	18	Baez	Baez	NNP
cord-329876-4cgrjnjo	247	19	-	-	HYPH
cord-329876-4cgrjnjo	247	20	Santos	Santos	NNP
cord-329876-4cgrjnjo	247	21	et	et	NNP
cord-329876-4cgrjnjo	247	22	al	al	NNP
cord-329876-4cgrjnjo	247	23	.	.	NNP
cord-329876-4cgrjnjo	247	24	,	,	,
cord-329876-4cgrjnjo	247	25	2014b	2014b	CD
cord-329876-4cgrjnjo	247	26	)	)	-RRB-
cord-329876-4cgrjnjo	247	27	.	.	.
cord-329876-4cgrjnjo	248	1	We	-PRON-	PRP
cord-329876-4cgrjnjo	248	2	have	have	VBP
cord-329876-4cgrjnjo	248	3	previously	previously	RB
cord-329876-4cgrjnjo	248	4	noticed	notice	VBN
cord-329876-4cgrjnjo	248	5	that	that	IN
cord-329876-4cgrjnjo	248	6	the	the	DT
cord-329876-4cgrjnjo	248	7	oxyanion	oxyanion	NN
cord-329876-4cgrjnjo	248	8	hole	hole	NN
cord-329876-4cgrjnjo	248	9	of	of	IN
cord-329876-4cgrjnjo	248	10	the	the	DT
cord-329876-4cgrjnjo	248	11	MERS	MERS	NNP
cord-329876-4cgrjnjo	248	12	-	-	HYPH
cord-329876-4cgrjnjo	248	13	CoV	cov	NN
cord-329876-4cgrjnjo	248	14	PL	pl	NN
cord-329876-4cgrjnjo	248	15	pro	pro	NNP
cord-329876-4cgrjnjo	248	16	appears	appear	VBZ
cord-329876-4cgrjnjo	248	17	to	to	TO
cord-329876-4cgrjnjo	248	18	be	be	VB
cord-329876-4cgrjnjo	248	19	deficient	deficient	JJ
cord-329876-4cgrjnjo	249	1	(	(	-LRB-
cord-329876-4cgrjnjo	249	2	Lei	Lei	NNP
cord-329876-4cgrjnjo	249	3	et	et	FW
cord-329876-4cgrjnjo	249	4	al	al	NNP
cord-329876-4cgrjnjo	249	5	.	.	NNP
cord-329876-4cgrjnjo	249	6	,	,	,
cord-329876-4cgrjnjo	249	7	2014	2014	CD
cord-329876-4cgrjnjo	249	8	;	;	:
cord-329876-4cgrjnjo	249	9	also	also	RB
cord-329876-4cgrjnjo	249	10	see	see	VB
cord-329876-4cgrjnjo	249	11	the	the	DT
cord-329876-4cgrjnjo	249	12	discussion	discussion	NN
cord-329876-4cgrjnjo	249	13	below	below	RB
cord-329876-4cgrjnjo	249	14	)	)	-RRB-
cord-329876-4cgrjnjo	249	15	.	.	.
cord-329876-4cgrjnjo	250	1	Similarly	similarly	RB
cord-329876-4cgrjnjo	250	2	,	,	,
cord-329876-4cgrjnjo	250	3	the	the	DT
cord-329876-4cgrjnjo	250	4	recognition	recognition	NN
cord-329876-4cgrjnjo	250	5	of	of	IN
cord-329876-4cgrjnjo	250	6	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	250	7	by	by	IN
cord-329876-4cgrjnjo	250	8	the	the	DT
cord-329876-4cgrjnjo	250	9	enzyme	enzyme	NN
cord-329876-4cgrjnjo	250	10	appears	appear	VBZ
cord-329876-4cgrjnjo	250	11	to	to	TO
cord-329876-4cgrjnjo	250	12	be	be	VB
cord-329876-4cgrjnjo	250	13	suboptimal	suboptimal	JJ
cord-329876-4cgrjnjo	250	14	.	.	.
cord-329876-4cgrjnjo	251	1	Thus	thus	RB
cord-329876-4cgrjnjo	251	2	,	,	,
cord-329876-4cgrjnjo	251	3	the	the	DT
cord-329876-4cgrjnjo	251	4	main	main	JJ
cord-329876-4cgrjnjo	251	5	-	-	HYPH
cord-329876-4cgrjnjo	251	6	chain	chain	NN
cord-329876-4cgrjnjo	251	7	amide	amide	NN
cord-329876-4cgrjnjo	251	8	of	of	IN
cord-329876-4cgrjnjo	251	9	the	the	DT
cord-329876-4cgrjnjo	251	10	P3-Arg	P3-Arg	NNP
cord-329876-4cgrjnjo	251	11	residue	residue	NN
cord-329876-4cgrjnjo	251	12	has	have	VBZ
cord-329876-4cgrjnjo	251	13	no	no	DT
cord-329876-4cgrjnjo	251	14	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	251	15	-	-	HYPH
cord-329876-4cgrjnjo	251	16	bonding	bond	VBG
cord-329876-4cgrjnjo	251	17	partner	partner	NN
cord-329876-4cgrjnjo	251	18	on	on	IN
cord-329876-4cgrjnjo	251	19	the	the	DT
cord-329876-4cgrjnjo	251	20	MERS	MERS	NNP
cord-329876-4cgrjnjo	251	21	-	-	HYPH
cord-329876-4cgrjnjo	251	22	CoV	CoV	NNP
cord-329876-4cgrjnjo	251	23	PL	pl	NN
cord-329876-4cgrjnjo	251	24	pro	pro	JJ
cord-329876-4cgrjnjo	251	25	,	,	,
cord-329876-4cgrjnjo	251	26	because	because	IN
cord-329876-4cgrjnjo	251	27	the	the	DT
cord-329876-4cgrjnjo	251	28	near	near	RB
cord-329876-4cgrjnjo	251	29	-	-	HYPH
cord-329876-4cgrjnjo	251	30	by	by	IN
cord-329876-4cgrjnjo	251	31	side	side	NN
cord-329876-4cgrjnjo	251	32	-	-	HYPH
cord-329876-4cgrjnjo	251	33	chain	chain	NN
cord-329876-4cgrjnjo	251	34	of	of	IN
cord-329876-4cgrjnjo	251	35	Phe269	phe269	CD
cord-329876-4cgrjnjo	251	36	is	be	VBZ
cord-329876-4cgrjnjo	251	37	incapable	incapable	JJ
cord-329876-4cgrjnjo	251	38	of	of	IN
cord-329876-4cgrjnjo	251	39	accepting	accept	VBG
cord-329876-4cgrjnjo	251	40	an	an	DT
cord-329876-4cgrjnjo	251	41	H	h	NN
cord-329876-4cgrjnjo	251	42	-	-	HYPH
cord-329876-4cgrjnjo	251	43	bond	bond	NN
cord-329876-4cgrjnjo	251	44	.	.	.
cord-329876-4cgrjnjo	252	1	The	the	DT
cord-329876-4cgrjnjo	252	2	corresponding	corresponding	JJ
cord-329876-4cgrjnjo	252	3	residue	residue	NN
cord-329876-4cgrjnjo	252	4	is	be	VBZ
cord-329876-4cgrjnjo	252	5	Tyr265	tyr265	NN
cord-329876-4cgrjnjo	252	6	in	in	IN
cord-329876-4cgrjnjo	252	7	the	the	DT
cord-329876-4cgrjnjo	252	8	SARS	SARS	NNP
cord-329876-4cgrjnjo	252	9	-	-	HYPH
cord-329876-4cgrjnjo	252	10	CoV	CoV	NNP
cord-329876-4cgrjnjo	252	11	PL	PL	NNP
cord-329876-4cgrjnjo	252	12	pro	pro	NNP
cord-329876-4cgrjnjo	252	13	,	,	,
cord-329876-4cgrjnjo	252	14	which	which	WDT
cord-329876-4cgrjnjo	252	15	is	be	VBZ
cord-329876-4cgrjnjo	252	16	perfectly	perfectly	RB
cord-329876-4cgrjnjo	252	17	positioned	position	VBN
cord-329876-4cgrjnjo	252	18	to	to	TO
cord-329876-4cgrjnjo	252	19	accept	accept	VB
cord-329876-4cgrjnjo	252	20	the	the	DT
cord-329876-4cgrjnjo	252	21	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	252	22	bond	bond	NN
cord-329876-4cgrjnjo	252	23	from	from	IN
cord-329876-4cgrjnjo	252	24	the	the	DT
cord-329876-4cgrjnjo	252	25	P3-amide	P3-amide	NNS
cord-329876-4cgrjnjo	252	26	.	.	.
cord-329876-4cgrjnjo	253	1	Indeed	indeed	RB
cord-329876-4cgrjnjo	253	2	,	,	,
cord-329876-4cgrjnjo	253	3	when	when	WRB
cord-329876-4cgrjnjo	253	4	we	-PRON-	PRP
cord-329876-4cgrjnjo	253	5	replaced	replace	VBD
cord-329876-4cgrjnjo	253	6	Phe269	phe269	IN
cord-329876-4cgrjnjo	253	7	by	by	IN
cord-329876-4cgrjnjo	253	8	Tyr	Tyr	NNP
cord-329876-4cgrjnjo	253	9	in	in	IN
cord-329876-4cgrjnjo	253	10	MERS	MERS	NNP
cord-329876-4cgrjnjo	253	11	-	-	HYPH
cord-329876-4cgrjnjo	253	12	CoV	cov	NN
cord-329876-4cgrjnjo	253	13	PL	pl	NN
cord-329876-4cgrjnjo	253	14	pro	pro	NN
cord-329876-4cgrjnjo	253	15	,	,	,
cord-329876-4cgrjnjo	254	1	the	the	DT
cord-329876-4cgrjnjo	254	2	DUB	DUB	NNP
cord-329876-4cgrjnjo	254	3	activity	activity	NN
cord-329876-4cgrjnjo	254	4	of	of	IN
cord-329876-4cgrjnjo	254	5	the	the	DT
cord-329876-4cgrjnjo	254	6	enzyme	enzyme	NN
cord-329876-4cgrjnjo	254	7	increased	increase	VBN
cord-329876-4cgrjnjo	254	8	by	by	IN
cord-329876-4cgrjnjo	254	9	a	a	DT
cord-329876-4cgrjnjo	254	10	factor	factor	NN
cord-329876-4cgrjnjo	254	11	of	of	IN
cord-329876-4cgrjnjo	254	12	almost	almost	RB
cord-329876-4cgrjnjo	254	13	2	2	CD
cord-329876-4cgrjnjo	254	14	and	and	CC
cord-329876-4cgrjnjo	254	15	the	the	DT
cord-329876-4cgrjnjo	254	16	peptidolytic	peptidolytic	JJ
cord-329876-4cgrjnjo	254	17	activity	activity	NN
cord-329876-4cgrjnjo	254	18	by	by	IN
cord-329876-4cgrjnjo	254	19	~1.5	~1.5	CD
cord-329876-4cgrjnjo	254	20	.	.	.
cord-329876-4cgrjnjo	255	1	The	the	DT
cord-329876-4cgrjnjo	255	2	evolution	evolution	NN
cord-329876-4cgrjnjo	255	3	of	of	IN
cord-329876-4cgrjnjo	255	4	viral	viral	JJ
cord-329876-4cgrjnjo	255	5	enzymes	enzyme	NNS
cord-329876-4cgrjnjo	255	6	is	be	VBZ
cord-329876-4cgrjnjo	255	7	not	not	RB
cord-329876-4cgrjnjo	255	8	neces	neces	JJ
cord-329876-4cgrjnjo	255	9	-	-	HYPH
cord-329876-4cgrjnjo	255	10	sarily	sarily	RB
cord-329876-4cgrjnjo	255	11	driven	drive	VBN
cord-329876-4cgrjnjo	255	12	by	by	IN
cord-329876-4cgrjnjo	255	13	optimization	optimization	NN
cord-329876-4cgrjnjo	255	14	of	of	IN
cord-329876-4cgrjnjo	255	15	catalytic	catalytic	JJ
cord-329876-4cgrjnjo	255	16	efficiency	efficiency	NN
cord-329876-4cgrjnjo	255	17	.	.	.
cord-329876-4cgrjnjo	256	1	This	this	DT
cord-329876-4cgrjnjo	256	2	is	be	VBZ
cord-329876-4cgrjnjo	256	3	particularly	particularly	RB
cord-329876-4cgrjnjo	256	4	true	true	JJ
cord-329876-4cgrjnjo	256	5	for	for	IN
cord-329876-4cgrjnjo	256	6	viral	viral	JJ
cord-329876-4cgrjnjo	256	7	proteases	protease	NNS
cord-329876-4cgrjnjo	256	8	that	that	WDT
cord-329876-4cgrjnjo	256	9	have	have	VBP
cord-329876-4cgrjnjo	256	10	to	to	TO
cord-329876-4cgrjnjo	256	11	ensure	ensure	VB
cord-329876-4cgrjnjo	256	12	the	the	DT
cord-329876-4cgrjnjo	256	13	availability	availability	NN
cord-329876-4cgrjnjo	256	14	of	of	IN
cord-329876-4cgrjnjo	256	15	non	non	JJ
cord-329876-4cgrjnjo	256	16	-	-	JJ
cord-329876-4cgrjnjo	256	17	structural	structural	JJ
cord-329876-4cgrjnjo	256	18	proteins	protein	NNS
cord-329876-4cgrjnjo	256	19	in	in	IN
cord-329876-4cgrjnjo	256	20	the	the	DT
cord-329876-4cgrjnjo	256	21	correct	correct	JJ
cord-329876-4cgrjnjo	256	22	temporal	temporal	JJ
cord-329876-4cgrjnjo	256	23	order	order	NN
cord-329876-4cgrjnjo	256	24	when	when	WRB
cord-329876-4cgrjnjo	256	25	they	-PRON-	PRP
cord-329876-4cgrjnjo	256	26	cleave	cleave	VBP
cord-329876-4cgrjnjo	256	27	them	-PRON-	PRP
cord-329876-4cgrjnjo	256	28	out	out	IN
cord-329876-4cgrjnjo	256	29	of	of	IN
cord-329876-4cgrjnjo	256	30	the	the	DT
cord-329876-4cgrjnjo	256	31	viral	viral	JJ
cord-329876-4cgrjnjo	256	32	polyproteins	polyprotein	NNS
cord-329876-4cgrjnjo	256	33	;	;	:
cord-329876-4cgrjnjo	256	34	in	in	IN
cord-329876-4cgrjnjo	256	35	fact	fact	NN
cord-329876-4cgrjnjo	256	36	,	,	,
cord-329876-4cgrjnjo	256	37	too	too	RB
cord-329876-4cgrjnjo	256	38	rapid	rapid	JJ
cord-329876-4cgrjnjo	256	39	a	a	DT
cord-329876-4cgrjnjo	256	40	polyprotein	polyprotein	JJ
cord-329876-4cgrjnjo	256	41	processing	processing	NN
cord-329876-4cgrjnjo	256	42	might	may	MD
cord-329876-4cgrjnjo	256	43	be	be	VB
cord-329876-4cgrjnjo	256	44	counterproductive	counterproductive	JJ
cord-329876-4cgrjnjo	256	45	.	.	.
cord-329876-4cgrjnjo	257	1	On	on	IN
cord-329876-4cgrjnjo	257	2	the	the	DT
cord-329876-4cgrjnjo	257	3	other	other	JJ
cord-329876-4cgrjnjo	257	4	hand	hand	NN
cord-329876-4cgrjnjo	257	5	,	,	,
cord-329876-4cgrjnjo	257	6	a	a	DT
cord-329876-4cgrjnjo	257	7	more	more	RBR
cord-329876-4cgrjnjo	257	8	efficient	efficient	JJ
cord-329876-4cgrjnjo	257	9	DUB	dub	NN
cord-329876-4cgrjnjo	257	10	activity	activity	NN
cord-329876-4cgrjnjo	257	11	should	should	MD
cord-329876-4cgrjnjo	257	12	help	help	VB
cord-329876-4cgrjnjo	257	13	the	the	DT
cord-329876-4cgrjnjo	257	14	virus	virus	NN
cord-329876-4cgrjnjo	257	15	in	in	IN
cord-329876-4cgrjnjo	257	16	counteracting	counteract	VBG
cord-329876-4cgrjnjo	257	17	the	the	DT
cord-329876-4cgrjnjo	257	18	innate	innate	JJ
cord-329876-4cgrjnjo	257	19	immune	immune	JJ
cord-329876-4cgrjnjo	257	20	response	response	NN
cord-329876-4cgrjnjo	257	21	of	of	IN
cord-329876-4cgrjnjo	257	22	the	the	DT
cord-329876-4cgrjnjo	257	23	host	host	NN
cord-329876-4cgrjnjo	257	24	cell	cell	NN
cord-329876-4cgrjnjo	257	25	.	.	.
cord-329876-4cgrjnjo	258	1	As	as	IN
cord-329876-4cgrjnjo	258	2	the	the	DT
cord-329876-4cgrjnjo	258	3	binding	binding	NN
cord-329876-4cgrjnjo	258	4	of	of	IN
cord-329876-4cgrjnjo	258	5	the	the	DT
cord-329876-4cgrjnjo	258	6	P5-P1	P5-P1	NNP
cord-329876-4cgrjnjo	258	7	residues	residue	NNS
cord-329876-4cgrjnjo	258	8	of	of	IN
cord-329876-4cgrjnjo	258	9	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	258	10	and	and	CC
cord-329876-4cgrjnjo	258	11	of	of	IN
cord-329876-4cgrjnjo	258	12	the	the	DT
cord-329876-4cgrjnjo	258	13	polyprotein	polyprotein	JJ
cord-329876-4cgrjnjo	258	14	cleavage	cleavage	NN
cord-329876-4cgrjnjo	258	15	sites	site	NNS
cord-329876-4cgrjnjo	258	16	obviously	obviously	RB
cord-329876-4cgrjnjo	258	17	influences	influence	VBZ
cord-329876-4cgrjnjo	258	18	both	both	CC
cord-329876-4cgrjnjo	258	19	the	the	DT
cord-329876-4cgrjnjo	258	20	DUB	dub	NN
cord-329876-4cgrjnjo	258	21	and	and	CC
cord-329876-4cgrjnjo	258	22	proteolytic	proteolytic	JJ
cord-329876-4cgrjnjo	258	23	activities	activity	NNS
cord-329876-4cgrjnjo	258	24	of	of	IN
cord-329876-4cgrjnjo	258	25	the	the	DT
cord-329876-4cgrjnjo	258	26	PL	pl	NN
cord-329876-4cgrjnjo	258	27	pro	pro	NN
cord-329876-4cgrjnjo	258	28	,	,	,
cord-329876-4cgrjnjo	258	29	the	the	DT
cord-329876-4cgrjnjo	258	30	suboptimal	suboptimal	JJ
cord-329876-4cgrjnjo	258	31	catalytic	catalytic	JJ
cord-329876-4cgrjnjo	258	32	efficiency	efficiency	NN
cord-329876-4cgrjnjo	258	33	that	that	WDT
cord-329876-4cgrjnjo	258	34	we	-PRON-	PRP
cord-329876-4cgrjnjo	258	35	observe	observe	VBP
cord-329876-4cgrjnjo	258	36	may	may	MD
cord-329876-4cgrjnjo	258	37	be	be	VB
cord-329876-4cgrjnjo	258	38	a	a	DT
cord-329876-4cgrjnjo	258	39	consequence	consequence	NN
cord-329876-4cgrjnjo	258	40	of	of	IN
cord-329876-4cgrjnjo	258	41	a	a	DT
cord-329876-4cgrjnjo	258	42	compromise	compromise	NN
cord-329876-4cgrjnjo	258	43	between	between	IN
cord-329876-4cgrjnjo	258	44	the	the	DT
cord-329876-4cgrjnjo	258	45	requirements	requirement	NNS
cord-329876-4cgrjnjo	258	46	of	of	IN
cord-329876-4cgrjnjo	258	47	the	the	DT
cord-329876-4cgrjnjo	258	48	two	two	CD
cord-329876-4cgrjnjo	258	49	activities	activity	NNS
cord-329876-4cgrjnjo	258	50	.	.	.
cord-329876-4cgrjnjo	259	1	With	with	IN
cord-329876-4cgrjnjo	259	2	regard	regard	NN
cord-329876-4cgrjnjo	259	3	to	to	IN
cord-329876-4cgrjnjo	259	4	the	the	DT
cord-329876-4cgrjnjo	259	5	oxyanion	oxyanion	NN
cord-329876-4cgrjnjo	259	6	hole	hole	NN
cord-329876-4cgrjnjo	259	7	,	,	,
cord-329876-4cgrjnjo	259	8	we	-PRON-	PRP
cord-329876-4cgrjnjo	259	9	previously	previously	RB
cord-329876-4cgrjnjo	259	10	proposed	propose	VBD
cord-329876-4cgrjnjo	259	11	that	that	IN
cord-329876-4cgrjnjo	259	12	the	the	DT
cord-329876-4cgrjnjo	259	13	backbone	backbone	NN
cord-329876-4cgrjnjo	259	14	amide	amide	NN
cord-329876-4cgrjnjo	259	15	of	of	IN
cord-329876-4cgrjnjo	259	16	Asn109	asn109	DT
cord-329876-4cgrjnjo	259	17	(	(	-LRB-
cord-329876-4cgrjnjo	259	18	located	locate	VBN
cord-329876-4cgrjnjo	259	19	in	in	IN
cord-329876-4cgrjnjo	259	20	a	a	DT
cord-329876-4cgrjnjo	259	21	β	β	NN
cord-329876-4cgrjnjo	259	22	-	-	HYPH
cord-329876-4cgrjnjo	259	23	turn	turn	NN
cord-329876-4cgrjnjo	259	24	connecting	connect	VBG
cord-329876-4cgrjnjo	259	25	β7	β7	NNP
cord-329876-4cgrjnjo	259	26	and	and	CC
cord-329876-4cgrjnjo	259	27	α4	α4	NN
cord-329876-4cgrjnjo	259	28	,	,	,
cord-329876-4cgrjnjo	259	29	Figure	figure	NN
cord-329876-4cgrjnjo	259	30	4	4	CD
cord-329876-4cgrjnjo	259	31	)	)	-RRB-
cord-329876-4cgrjnjo	259	32	may	may	MD
cord-329876-4cgrjnjo	259	33	contribute	contribute	VB
cord-329876-4cgrjnjo	259	34	to	to	IN
cord-329876-4cgrjnjo	259	35	the	the	DT
cord-329876-4cgrjnjo	259	36	stabilization	stabilization	NN
cord-329876-4cgrjnjo	259	37	of	of	IN
cord-329876-4cgrjnjo	259	38	the	the	DT
cord-329876-4cgrjnjo	259	39	oxyanion	oxyanion	NN
cord-329876-4cgrjnjo	259	40	intermediate	intermediate	JJ
cord-329876-4cgrjnjo	259	41	in	in	IN
cord-329876-4cgrjnjo	259	42	PL	pl	NN
cord-329876-4cgrjnjo	259	43	pro	pro	JJ
cord-329876-4cgrjnjo	259	44	catalysis	catalysis	NN
cord-329876-4cgrjnjo	259	45	,	,	,
cord-329876-4cgrjnjo	259	46	along	along	IN
cord-329876-4cgrjnjo	259	47	with	with	IN
cord-329876-4cgrjnjo	259	48	the	the	DT
cord-329876-4cgrjnjo	259	49	main	main	JJ
cord-329876-4cgrjnjo	259	50	-	-	HYPH
cord-329876-4cgrjnjo	259	51	chain	chain	NN
cord-329876-4cgrjnjo	259	52	amide	amide	NN
cord-329876-4cgrjnjo	259	53	of	of	IN
cord-329876-4cgrjnjo	259	54	the	the	DT
cord-329876-4cgrjnjo	259	55	active	active	JJ
cord-329876-4cgrjnjo	259	56	site	site	NN
cord-329876-4cgrjnjo	260	1	Cys111	Cys111	:
cord-329876-4cgrjnjo	260	2	,	,	,
cord-329876-4cgrjnjo	260	3	although	although	IN
cord-329876-4cgrjnjo	260	4	this	this	DT
cord-329876-4cgrjnjo	260	5	may	may	MD
cord-329876-4cgrjnjo	260	6	require	require	VB
cord-329876-4cgrjnjo	260	7	a	a	DT
cord-329876-4cgrjnjo	260	8	slight	slight	JJ
cord-329876-4cgrjnjo	260	9	rearrangement	rearrangement	NN
cord-329876-4cgrjnjo	260	10	of	of	IN
cord-329876-4cgrjnjo	260	11	this	this	DT
cord-329876-4cgrjnjo	260	12	β	β	NN
cord-329876-4cgrjnjo	260	13	-	-	HYPH
cord-329876-4cgrjnjo	260	14	turn	turn	NN
cord-329876-4cgrjnjo	261	1	(	(	-LRB-
cord-329876-4cgrjnjo	261	2	Lei	Lei	NNP
cord-329876-4cgrjnjo	261	3	et	et	FW
cord-329876-4cgrjnjo	261	4	al	al	NNP
cord-329876-4cgrjnjo	261	5	.	.	NNP
cord-329876-4cgrjnjo	261	6	,	,	,
cord-329876-4cgrjnjo	261	7	2014	2014	CD
cord-329876-4cgrjnjo	261	8	)	)	-RRB-
cord-329876-4cgrjnjo	261	9	.	.	.
cord-329876-4cgrjnjo	262	1	In	in	IN
cord-329876-4cgrjnjo	262	2	our	-PRON-	PRP$
cord-329876-4cgrjnjo	262	3	non	non	JJ
cord-329876-4cgrjnjo	262	4	-	-	JJ
cord-329876-4cgrjnjo	262	5	covalent	covalent	JJ
cord-329876-4cgrjnjo	262	6	MERS	MERS	NNP
cord-329876-4cgrjnjo	262	7	-	-	HYPH
cord-329876-4cgrjnjo	262	8	CoV	cov	NN
cord-329876-4cgrjnjo	262	9	PL	pl	NN
cord-329876-4cgrjnjo	262	10	pro	pro	JJ
cord-329876-4cgrjnjo	262	11	-Ub	-ub	NN
cord-329876-4cgrjnjo	262	12	complex	complex	JJ
cord-329876-4cgrjnjo	262	13	,	,	,
cord-329876-4cgrjnjo	262	14	we	-PRON-	PRP
cord-329876-4cgrjnjo	262	15	do	do	VBP
cord-329876-4cgrjnjo	262	16	not	not	RB
cord-329876-4cgrjnjo	262	17	see	see	VB
cord-329876-4cgrjnjo	262	18	any	any	DT
cord-329876-4cgrjnjo	262	19	rearrangement	rearrangement	NN
cord-329876-4cgrjnjo	262	20	of	of	IN
cord-329876-4cgrjnjo	262	21	the	the	DT
cord-329876-4cgrjnjo	262	22	β	β	NN
cord-329876-4cgrjnjo	262	23	-	-	HYPH
cord-329876-4cgrjnjo	262	24	turn	turn	NN
cord-329876-4cgrjnjo	262	25	.	.	.
cord-329876-4cgrjnjo	263	1	More	More	JJR
cord-329876-4cgrjnjo	263	2	or	or	CC
cord-329876-4cgrjnjo	263	3	less	less	RBR
cord-329876-4cgrjnjo	263	4	in	in	IN
cord-329876-4cgrjnjo	263	5	agreement	agreement	NN
cord-329876-4cgrjnjo	263	6	with	with	IN
cord-329876-4cgrjnjo	263	7	our	-PRON-	PRP$
cord-329876-4cgrjnjo	263	8	suggestion	suggestion	NN
cord-329876-4cgrjnjo	263	9	,	,	,
cord-329876-4cgrjnjo	263	10	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	263	11	-	-	HYPH
cord-329876-4cgrjnjo	263	12	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	263	13	et	et	NNP
cord-329876-4cgrjnjo	263	14	al	al	NNP
cord-329876-4cgrjnjo	263	15	.	.	.
cord-329876-4cgrjnjo	264	1	(	(	-LRB-
cord-329876-4cgrjnjo	264	2	2014	2014	CD
cord-329876-4cgrjnjo	264	3	)	)	-RRB-
cord-329876-4cgrjnjo	264	4	proposed	propose	VBN
cord-329876-4cgrjnjo	264	5	on	on	IN
cord-329876-4cgrjnjo	264	6	the	the	DT
cord-329876-4cgrjnjo	264	7	basis	basis	NN
cord-329876-4cgrjnjo	264	8	of	of	IN
cord-329876-4cgrjnjo	264	9	their	-PRON-	PRP$
cord-329876-4cgrjnjo	264	10	covalent	covalent	JJ
cord-329876-4cgrjnjo	264	11	MERS	MERS	NNP
cord-329876-4cgrjnjo	264	12	-	-	HYPH
cord-329876-4cgrjnjo	264	13	CoV	cov	NN
cord-329876-4cgrjnjo	264	14	PL	pl	NN
cord-329876-4cgrjnjo	264	15	pro	pro	JJ
cord-329876-4cgrjnjo	264	16	-Ub	-ub	NN
cord-329876-4cgrjnjo	264	17	complex	complex	JJ
cord-329876-4cgrjnjo	264	18	structure	structure	NN
cord-329876-4cgrjnjo	264	19	that	that	IN
cord-329876-4cgrjnjo	264	20	the	the	DT
cord-329876-4cgrjnjo	264	21	main	main	JJ
cord-329876-4cgrjnjo	264	22	-	-	HYPH
cord-329876-4cgrjnjo	264	23	chain	chain	NN
cord-329876-4cgrjnjo	264	24	amides	amide	NNS
cord-329876-4cgrjnjo	264	25	of	of	IN
cord-329876-4cgrjnjo	264	26	Asn1590	Asn1590	NNP
cord-329876-4cgrjnjo	264	27	,	,	,
cord-329876-4cgrjnjo	264	28	Asn1591	Asn1591	NNP
cord-329876-4cgrjnjo	264	29	,	,	,
cord-329876-4cgrjnjo	264	30	and	and	CC
cord-329876-4cgrjnjo	264	31	Cys1592	Cys1592	NNP
cord-329876-4cgrjnjo	264	32	(	(	-LRB-
cord-329876-4cgrjnjo	264	33	corresponding	correspond	VBG
cord-329876-4cgrjnjo	264	34	to	to	IN
cord-329876-4cgrjnjo	264	35	Asn109	asn109	ADD
cord-329876-4cgrjnjo	264	36	,	,	,
cord-329876-4cgrjnjo	264	37	Asn110	asn110	UH
cord-329876-4cgrjnjo	264	38	,	,	,
cord-329876-4cgrjnjo	264	39	and	and	CC
cord-329876-4cgrjnjo	265	1	Cys111	Cys111	VBN
cord-329876-4cgrjnjo	265	2	in	in	IN
cord-329876-4cgrjnjo	265	3	our	-PRON-	PRP$
cord-329876-4cgrjnjo	265	4	numbering	number	VBG
cord-329876-4cgrjnjo	265	5	scheme	scheme	NN
cord-329876-4cgrjnjo	265	6	)	)	-RRB-
cord-329876-4cgrjnjo	265	7	form	form	VB
cord-329876-4cgrjnjo	265	8	the	the	DT
cord-329876-4cgrjnjo	265	9	oxyanion	oxyanion	NN
cord-329876-4cgrjnjo	265	10	hole	hole	NN
cord-329876-4cgrjnjo	265	11	.	.	.
cord-329876-4cgrjnjo	266	1	On	on	IN
cord-329876-4cgrjnjo	266	2	the	the	DT
cord-329876-4cgrjnjo	266	3	other	other	JJ
cord-329876-4cgrjnjo	266	4	hand	hand	NN
cord-329876-4cgrjnjo	266	5	,	,	,
cord-329876-4cgrjnjo	266	6	Lee	Lee	NNP
cord-329876-4cgrjnjo	266	7	et	et	NNP
cord-329876-4cgrjnjo	266	8	al	al	NNP
cord-329876-4cgrjnjo	266	9	.	.	.
cord-329876-4cgrjnjo	267	1	(	(	-LRB-
cord-329876-4cgrjnjo	267	2	2015	2015	CD
cord-329876-4cgrjnjo	267	3	)	)	-RRB-
cord-329876-4cgrjnjo	267	4	argued	argue	VBD
cord-329876-4cgrjnjo	267	5	that	that	IN
cord-329876-4cgrjnjo	267	6	the	the	DT
cord-329876-4cgrjnjo	267	7	side	side	NN
cord-329876-4cgrjnjo	267	8	-	-	HYPH
cord-329876-4cgrjnjo	267	9	chain	chain	NN
cord-329876-4cgrjnjo	267	10	of	of	IN
cord-329876-4cgrjnjo	267	11	Asn109	asn109	DT
cord-329876-4cgrjnjo	267	12	could	could	MD
cord-329876-4cgrjnjo	267	13	contribute	contribute	VB
cord-329876-4cgrjnjo	267	14	to	to	IN
cord-329876-4cgrjnjo	267	15	the	the	DT
cord-329876-4cgrjnjo	267	16	oxyanion	oxyanion	NN
cord-329876-4cgrjnjo	267	17	hole	hole	NN
cord-329876-4cgrjnjo	267	18	.	.	.
cord-329876-4cgrjnjo	268	1	They	-PRON-	PRP
cord-329876-4cgrjnjo	268	2	found	find	VBD
cord-329876-4cgrjnjo	268	3	that	that	IN
cord-329876-4cgrjnjo	268	4	the	the	DT
cord-329876-4cgrjnjo	268	5	N109A	n109a	JJ
cord-329876-4cgrjnjo	268	6	replacement	replacement	NN
cord-329876-4cgrjnjo	268	7	completely	completely	RB
cord-329876-4cgrjnjo	268	8	abolished	abolish	VBD
cord-329876-4cgrjnjo	268	9	enzyme	enzyme	NN
cord-329876-4cgrjnjo	268	10	activity	activity	NN
cord-329876-4cgrjnjo	268	11	.	.	.
cord-329876-4cgrjnjo	269	1	As	as	IN
cord-329876-4cgrjnjo	269	2	we	-PRON-	PRP
cord-329876-4cgrjnjo	269	3	reported	report	VBD
cord-329876-4cgrjnjo	269	4	earlier	early	RBR
cord-329876-4cgrjnjo	269	5	(	(	-LRB-
cord-329876-4cgrjnjo	269	6	Lei	Lei	NNP
cord-329876-4cgrjnjo	269	7	et	et	FW
cord-329876-4cgrjnjo	269	8	al	al	NNP
cord-329876-4cgrjnjo	269	9	.	.	NNP
cord-329876-4cgrjnjo	269	10	,	,	,
cord-329876-4cgrjnjo	269	11	2014	2014	CD
cord-329876-4cgrjnjo	269	12	)	)	-RRB-
cord-329876-4cgrjnjo	269	13	,	,	,
cord-329876-4cgrjnjo	269	14	the	the	DT
cord-329876-4cgrjnjo	269	15	side	side	NN
cord-329876-4cgrjnjo	269	16	-	-	HYPH
cord-329876-4cgrjnjo	269	17	chain	chain	NN
cord-329876-4cgrjnjo	269	18	amide	amide	NN
cord-329876-4cgrjnjo	269	19	of	of	IN
cord-329876-4cgrjnjo	269	20	Asn109	asn109	DT
cord-329876-4cgrjnjo	269	21	makes	make	VBZ
cord-329876-4cgrjnjo	269	22	a	a	DT
cord-329876-4cgrjnjo	269	23	strong	strong	JJ
cord-329876-4cgrjnjo	269	24	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	269	25	bond	bond	NN
cord-329876-4cgrjnjo	269	26	with	with	IN
cord-329876-4cgrjnjo	269	27	the	the	DT
cord-329876-4cgrjnjo	269	28	conserved	conserved	JJ
cord-329876-4cgrjnjo	269	29	Gly161	Gly161	.
cord-329876-4cgrjnjo	270	1	(	(	-LRB-
cord-329876-4cgrjnjo	270	2	Figure	figure	NN
cord-329876-4cgrjnjo	270	3	4	4	CD
cord-329876-4cgrjnjo	270	4	)	)	-RRB-
cord-329876-4cgrjnjo	270	5	.	.	.
cord-329876-4cgrjnjo	271	1	Any	any	DT
cord-329876-4cgrjnjo	271	2	reorientation	reorientation	NN
cord-329876-4cgrjnjo	271	3	of	of	IN
cord-329876-4cgrjnjo	271	4	the	the	DT
cord-329876-4cgrjnjo	271	5	Asn109	asn109	CD
cord-329876-4cgrjnjo	271	6	side	side	NN
cord-329876-4cgrjnjo	271	7	-	-	HYPH
cord-329876-4cgrjnjo	271	8	chain	chain	NN
cord-329876-4cgrjnjo	271	9	towards	towards	IN
cord-329876-4cgrjnjo	271	10	the	the	DT
cord-329876-4cgrjnjo	271	11	oxyanion	oxyanion	NN
cord-329876-4cgrjnjo	271	12	would	would	MD
cord-329876-4cgrjnjo	271	13	require	require	VB
cord-329876-4cgrjnjo	271	14	a	a	DT
cord-329876-4cgrjnjo	271	15	disruption	disruption	NN
cord-329876-4cgrjnjo	271	16	of	of	IN
cord-329876-4cgrjnjo	271	17	this	this	DT
cord-329876-4cgrjnjo	271	18	strong	strong	JJ
cord-329876-4cgrjnjo	271	19	interaction	interaction	NN
cord-329876-4cgrjnjo	271	20	;	;	:
cord-329876-4cgrjnjo	271	21	this	this	DT
cord-329876-4cgrjnjo	271	22	is	be	VBZ
cord-329876-4cgrjnjo	271	23	not	not	RB
cord-329876-4cgrjnjo	271	24	very	very	RB
cord-329876-4cgrjnjo	271	25	likely	likely	JJ
cord-329876-4cgrjnjo	271	26	.	.	.
cord-329876-4cgrjnjo	272	1	In	in	IN
cord-329876-4cgrjnjo	272	2	conclusion	conclusion	NN
cord-329876-4cgrjnjo	272	3	,	,	,
cord-329876-4cgrjnjo	272	4	lacking	lack	VBG
cord-329876-4cgrjnjo	272	5	a	a	DT
cord-329876-4cgrjnjo	272	6	side	side	NN
cord-329876-4cgrjnjo	272	7	-	-	HYPH
cord-329876-4cgrjnjo	272	8	chain	chain	NN
cord-329876-4cgrjnjo	272	9	in	in	IN
cord-329876-4cgrjnjo	272	10	the	the	DT
cord-329876-4cgrjnjo	272	11	proper	proper	JJ
cord-329876-4cgrjnjo	272	12	spatial	spatial	JJ
cord-329876-4cgrjnjo	272	13	orientation	orientation	NN
cord-329876-4cgrjnjo	272	14	and	and	CC
cord-329876-4cgrjnjo	272	15	capable	capable	JJ
cord-329876-4cgrjnjo	272	16	of	of	IN
cord-329876-4cgrjnjo	272	17	donating	donate	VBG
cord-329876-4cgrjnjo	272	18	a	a	DT
cord-329876-4cgrjnjo	272	19	hydrogen	hydrogen	NN
cord-329876-4cgrjnjo	272	20	bond	bond	NN
cord-329876-4cgrjnjo	272	21	to	to	IN
cord-329876-4cgrjnjo	272	22	the	the	DT
cord-329876-4cgrjnjo	272	23	oxyanion	oxyanion	NN
cord-329876-4cgrjnjo	272	24	(	(	-LRB-
cord-329876-4cgrjnjo	272	25	such	such	JJ
cord-329876-4cgrjnjo	272	26	as	as	IN
cord-329876-4cgrjnjo	272	27	Trp107	trp107	CD
cord-329876-4cgrjnjo	272	28	in	in	IN
cord-329876-4cgrjnjo	272	29	SARS	SARS	NNP
cord-329876-4cgrjnjo	272	30	-	-	HYPH
cord-329876-4cgrjnjo	272	31	CoV	CoV	NNP
cord-329876-4cgrjnjo	272	32	PL	PL	NNP
cord-329876-4cgrjnjo	272	33	pro	pro	NNP
cord-329876-4cgrjnjo	272	34	)	)	-RRB-
cord-329876-4cgrjnjo	272	35	,	,	,
cord-329876-4cgrjnjo	272	36	the	the	DT
cord-329876-4cgrjnjo	272	37	oxyanion	oxyanion	NN
cord-329876-4cgrjnjo	272	38	hole	hole	NN
cord-329876-4cgrjnjo	272	39	of	of	IN
cord-329876-4cgrjnjo	272	40	MERS	MERS	NNP
cord-329876-4cgrjnjo	272	41	-	-	HYPH
cord-329876-4cgrjnjo	272	42	CoV	CoV	NNP
cord-329876-4cgrjnjo	272	43	PL	pl	NN
cord-329876-4cgrjnjo	272	44	pro	pro	NNP
cord-329876-4cgrjnjo	272	45	seems	seem	VBZ
cord-329876-4cgrjnjo	272	46	to	to	TO
cord-329876-4cgrjnjo	272	47	be	be	VB
cord-329876-4cgrjnjo	272	48	deficient	deficient	JJ
cord-329876-4cgrjnjo	272	49	.	.	.
cord-329876-4cgrjnjo	273	1	Apart	apart	RB
cord-329876-4cgrjnjo	273	2	from	from	IN
cord-329876-4cgrjnjo	273	3	the	the	DT
cord-329876-4cgrjnjo	273	4	less	less	RBR
cord-329876-4cgrjnjo	273	5	than	than	IN
cord-329876-4cgrjnjo	273	6	optimum	optimum	JJ
cord-329876-4cgrjnjo	273	7	binding	binding	NN
cord-329876-4cgrjnjo	273	8	of	of	IN
cord-329876-4cgrjnjo	273	9	the	the	DT
cord-329876-4cgrjnjo	273	10	P3	P3	NNP
cord-329876-4cgrjnjo	273	11	residue	residue	NN
cord-329876-4cgrjnjo	273	12	,	,	,
cord-329876-4cgrjnjo	273	13	there	there	EX
cord-329876-4cgrjnjo	273	14	are	be	VBP
cord-329876-4cgrjnjo	273	15	other	other	JJ
cord-329876-4cgrjnjo	273	16	differences	difference	NNS
cord-329876-4cgrjnjo	273	17	in	in	IN
cord-329876-4cgrjnjo	273	18	the	the	DT
cord-329876-4cgrjnjo	273	19	way	way	NN
cord-329876-4cgrjnjo	273	20	MERS	MERS	NNP
cord-329876-4cgrjnjo	273	21	-	-	HYPH
cord-329876-4cgrjnjo	273	22	CoV	CoV	NNP
cord-329876-4cgrjnjo	273	23	PL	pl	NN
cord-329876-4cgrjnjo	273	24	pro	pro	NNP
cord-329876-4cgrjnjo	273	25	and	and	CC
cord-329876-4cgrjnjo	273	26	SARS	SARS	NNP
cord-329876-4cgrjnjo	273	27	-	-	HYPH
cord-329876-4cgrjnjo	273	28	CoV	CoV	NNP
cord-329876-4cgrjnjo	273	29	PL	pl	NN
cord-329876-4cgrjnjo	273	30	pro	pro	JJ
cord-329876-4cgrjnjo	273	31	recognize	recognize	VB
cord-329876-4cgrjnjo	273	32	human	human	JJ
cord-329876-4cgrjnjo	273	33	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	273	34	.	.	.
cord-329876-4cgrjnjo	274	1	The	the	DT
cord-329876-4cgrjnjo	274	2	formation	formation	NN
cord-329876-4cgrjnjo	274	3	of	of	IN
cord-329876-4cgrjnjo	274	4	a	a	DT
cord-329876-4cgrjnjo	274	5	salt	salt	NN
cord-329876-4cgrjnjo	274	6	-	-	HYPH
cord-329876-4cgrjnjo	274	7	bridge	bridge	NN
cord-329876-4cgrjnjo	274	8	between	between	IN
cord-329876-4cgrjnjo	274	9	Arg72	Arg72	NNP
cord-329876-4cgrjnjo	274	10	,	,	,
cord-329876-4cgrjnjo	274	11	the	the	DT
cord-329876-4cgrjnjo	274	12	P5	p5	NN
cord-329876-4cgrjnjo	274	13	side	side	NN
cord-329876-4cgrjnjo	274	14	-	-	HYPH
cord-329876-4cgrjnjo	274	15	chain	chain	NN
cord-329876-4cgrjnjo	274	16	of	of	IN
cord-329876-4cgrjnjo	274	17	Ub	Ub	NNP
cord-329876-4cgrjnjo	274	18	,	,	,
cord-329876-4cgrjnjo	274	19	and	and	CC
cord-329876-4cgrjnjo	274	20	Asp164	asp164	CD
cord-329876-4cgrjnjo	274	21	is	be	VBZ
cord-329876-4cgrjnjo	274	22	unique	unique	JJ
cord-329876-4cgrjnjo	274	23	for	for	IN
cord-329876-4cgrjnjo	274	24	MERS	MERS	NNP
cord-329876-4cgrjnjo	274	25	-	-	HYPH
cord-329876-4cgrjnjo	274	26	CoV	CoV	NNP
cord-329876-4cgrjnjo	274	27	PL	pl	NN
cord-329876-4cgrjnjo	274	28	pro	pro	NNP
cord-329876-4cgrjnjo	274	29	.	.	.
cord-329876-4cgrjnjo	275	1	The	the	DT
cord-329876-4cgrjnjo	275	2	same	same	JJ
cord-329876-4cgrjnjo	275	3	interaction	interaction	NN
cord-329876-4cgrjnjo	275	4	exists	exist	VBZ
cord-329876-4cgrjnjo	275	5	in	in	IN
cord-329876-4cgrjnjo	275	6	the	the	DT
cord-329876-4cgrjnjo	275	7	two	two	CD
cord-329876-4cgrjnjo	275	8	covalent	covalent	JJ
cord-329876-4cgrjnjo	275	9	MERS	MERS	NNP
cord-329876-4cgrjnjo	275	10	-	-	HYPH
cord-329876-4cgrjnjo	275	11	CoV	cov	NN
cord-329876-4cgrjnjo	275	12	PL	pl	NN
cord-329876-4cgrjnjo	275	13	pro	pro	JJ
cord-329876-4cgrjnjo	275	14	-Ub	-ub	NN
cord-329876-4cgrjnjo	275	15	complexes	complex	NNS
cord-329876-4cgrjnjo	275	16	(	(	-LRB-
cord-329876-4cgrjnjo	275	17	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	275	18	-	-	HYPH
cord-329876-4cgrjnjo	275	19	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	275	20	et	et	NNP
cord-329876-4cgrjnjo	275	21	al	al	NNP
cord-329876-4cgrjnjo	275	22	.	.	.
cord-329876-4cgrjnjo	276	1	,	,	,
cord-329876-4cgrjnjo	276	2	2014	2014	CD
cord-329876-4cgrjnjo	276	3	)	)	-RRB-
cord-329876-4cgrjnjo	276	4	.	.	.
cord-329876-4cgrjnjo	277	1	This	this	DT
cord-329876-4cgrjnjo	277	2	binding	binding	NN
cord-329876-4cgrjnjo	277	3	mode	mode	NN
cord-329876-4cgrjnjo	277	4	is	be	VBZ
cord-329876-4cgrjnjo	277	5	very	very	RB
cord-329876-4cgrjnjo	277	6	different	different	JJ
cord-329876-4cgrjnjo	277	7	from	from	IN
cord-329876-4cgrjnjo	277	8	the	the	DT
cord-329876-4cgrjnjo	277	9	Glu168	Glu168	NNP
cord-329876-4cgrjnjo	277	10	-Arg72	-Arg72	NNP
cord-329876-4cgrjnjo	277	11	salt	salt	NN
cord-329876-4cgrjnjo	277	12	-	-	HYPH
cord-329876-4cgrjnjo	277	13	bridge	bridge	NN
cord-329876-4cgrjnjo	277	14	in	in	IN
cord-329876-4cgrjnjo	277	15	the	the	DT
cord-329876-4cgrjnjo	277	16	SARS	SARS	NNP
cord-329876-4cgrjnjo	277	17	-	-	HYPH
cord-329876-4cgrjnjo	277	18	CoV	CoV	NNP
cord-329876-4cgrjnjo	277	19	PL	pl	NN
cord-329876-4cgrjnjo	277	20	pro	pro	NNP
cord-329876-4cgrjnjo	277	21	-Ubal	-Ubal	NNP
cord-329876-4cgrjnjo	277	22	complex	complex	JJ
cord-329876-4cgrjnjo	278	1	(	(	-LRB-
cord-329876-4cgrjnjo	278	2	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	278	3	et	et	NNP
cord-329876-4cgrjnjo	278	4	al	al	NNP
cord-329876-4cgrjnjo	278	5	.	.	NNP
cord-329876-4cgrjnjo	278	6	,	,	,
cord-329876-4cgrjnjo	278	7	2014	2014	CD
cord-329876-4cgrjnjo	278	8	)	)	-RRB-
cord-329876-4cgrjnjo	278	9	.	.	.
cord-329876-4cgrjnjo	279	1	Glu168	Glu168	NNP
cord-329876-4cgrjnjo	279	2	is	be	VBZ
cord-329876-4cgrjnjo	279	3	conserved	conserve	VBN
cord-329876-4cgrjnjo	279	4	in	in	IN
cord-329876-4cgrjnjo	279	5	HCoV	HCoV	NNP
cord-329876-4cgrjnjo	280	1	-NL63	-NL63	:
cord-329876-4cgrjnjo	280	2	PL2	PL2	NNP
cord-329876-4cgrjnjo	280	3	pro	pro	NNP
cord-329876-4cgrjnjo	280	4	and	and	CC
cord-329876-4cgrjnjo	280	5	replaced	replace	VBN
cord-329876-4cgrjnjo	280	6	by	by	IN
cord-329876-4cgrjnjo	280	7	Asp	Asp	NNP
cord-329876-4cgrjnjo	280	8	in	in	IN
cord-329876-4cgrjnjo	280	9	the	the	DT
cord-329876-4cgrjnjo	280	10	HCoV-229E	HCoV-229E	NNP
cord-329876-4cgrjnjo	280	11	,	,	,
cord-329876-4cgrjnjo	280	12	HCoV	HCoV	NNP
cord-329876-4cgrjnjo	280	13	-	-	HYPH
cord-329876-4cgrjnjo	280	14	OC43	OC43	NNP
cord-329876-4cgrjnjo	280	15	,	,	,
cord-329876-4cgrjnjo	280	16	and	and	CC
cord-329876-4cgrjnjo	280	17	HCoV	HCoV	NNP
cord-329876-4cgrjnjo	280	18	-	-	HYPH
cord-329876-4cgrjnjo	280	19	HKU1	HKU1	NNP
cord-329876-4cgrjnjo	280	20	PL2	PL2	NNP
cord-329876-4cgrjnjo	280	21	pro	pro	NNP
cord-329876-4cgrjnjo	280	22	s	s	NNP
cord-329876-4cgrjnjo	280	23	(	(	-LRB-
cord-329876-4cgrjnjo	280	24	for	for	IN
cord-329876-4cgrjnjo	280	25	sequence	sequence	NN
cord-329876-4cgrjnjo	280	26	alignments	alignment	NNS
cord-329876-4cgrjnjo	280	27	,	,	,
cord-329876-4cgrjnjo	280	28	see	see	VB
cord-329876-4cgrjnjo	280	29	Barretto	Barretto	NNP
cord-329876-4cgrjnjo	280	30	et	et	NNP
cord-329876-4cgrjnjo	280	31	al	al	NNP
cord-329876-4cgrjnjo	280	32	.	.	NNP
cord-329876-4cgrjnjo	280	33	,	,	,
cord-329876-4cgrjnjo	280	34	2005	2005	CD
cord-329876-4cgrjnjo	280	35	;	;	:
cord-329876-4cgrjnjo	280	36	Baez	Baez	NNP
cord-329876-4cgrjnjo	280	37	-	-	HYPH
cord-329876-4cgrjnjo	280	38	Santos	Santos	NNP
cord-329876-4cgrjnjo	280	39	et	et	NNP
cord-329876-4cgrjnjo	280	40	al	al	NNP
cord-329876-4cgrjnjo	280	41	.	.	NNP
cord-329876-4cgrjnjo	280	42	,	,	,
cord-329876-4cgrjnjo	280	43	2014b	2014b	CD
cord-329876-4cgrjnjo	280	44	)	)	-RRB-
cord-329876-4cgrjnjo	280	45	,	,	,
cord-329876-4cgrjnjo	280	46	so	so	CC
cord-329876-4cgrjnjo	280	47	the	the	DT
cord-329876-4cgrjnjo	280	48	same	same	JJ
cord-329876-4cgrjnjo	280	49	type	type	NN
cord-329876-4cgrjnjo	280	50	of	of	IN
cord-329876-4cgrjnjo	280	51	interaction	interaction	NN
cord-329876-4cgrjnjo	280	52	is	be	VBZ
cord-329876-4cgrjnjo	280	53	likely	likely	JJ
cord-329876-4cgrjnjo	280	54	to	to	TO
cord-329876-4cgrjnjo	280	55	be	be	VB
cord-329876-4cgrjnjo	280	56	realized	realize	VBN
cord-329876-4cgrjnjo	280	57	in	in	IN
cord-329876-4cgrjnjo	280	58	the	the	DT
cord-329876-4cgrjnjo	280	59	Ub	ub	JJ
cord-329876-4cgrjnjo	280	60	complexes	complex	NNS
cord-329876-4cgrjnjo	280	61	of	of	IN
cord-329876-4cgrjnjo	280	62	these	these	DT
cord-329876-4cgrjnjo	280	63	enzymes	enzyme	NNS
cord-329876-4cgrjnjo	280	64	.	.	.
cord-329876-4cgrjnjo	281	1	However	however	RB
cord-329876-4cgrjnjo	281	2	,	,	,
cord-329876-4cgrjnjo	281	3	the	the	DT
cord-329876-4cgrjnjo	281	4	corresponding	corresponding	JJ
cord-329876-4cgrjnjo	281	5	residue	residue	NN
cord-329876-4cgrjnjo	281	6	in	in	IN
cord-329876-4cgrjnjo	281	7	MERS	MERS	NNP
cord-329876-4cgrjnjo	281	8	-	-	HYPH
cord-329876-4cgrjnjo	281	9	CoV	CoV	NNP
cord-329876-4cgrjnjo	281	10	PL	pl	NN
cord-329876-4cgrjnjo	281	11	pro	pro	NNP
cord-329876-4cgrjnjo	281	12	is	be	VBZ
cord-329876-4cgrjnjo	281	13	Arg168	Arg168	,
cord-329876-4cgrjnjo	281	14	;	;	:
cord-329876-4cgrjnjo	281	15	hence	hence	RB
cord-329876-4cgrjnjo	281	16	,	,	,
cord-329876-4cgrjnjo	281	17	Asp164	asp164	ADD
cord-329876-4cgrjnjo	281	18	is	be	VBZ
cord-329876-4cgrjnjo	281	19	used	use	VBN
cord-329876-4cgrjnjo	281	20	instead	instead	RB
cord-329876-4cgrjnjo	281	21	to	to	TO
cord-329876-4cgrjnjo	281	22	bind	bind	VB
cord-329876-4cgrjnjo	281	23	Arg72	Arg72	NNP
cord-329876-4cgrjnjo	281	24	.	.	.
cord-329876-4cgrjnjo	282	1	Asp164	asp164	CD
cord-329876-4cgrjnjo	282	2	is	be	VBZ
cord-329876-4cgrjnjo	282	3	in	in	IN
cord-329876-4cgrjnjo	282	4	fact	fact	NN
cord-329876-4cgrjnjo	282	5	unique	unique	JJ
cord-329876-4cgrjnjo	282	6	in	in	IN
cord-329876-4cgrjnjo	282	7	MERS-	MERS-	NNP
cord-329876-4cgrjnjo	283	1	CoV.	CoV.	NNP
cord-329876-4cgrjnjo	284	1	It	-PRON-	PRP
cord-329876-4cgrjnjo	284	2	is	be	VBZ
cord-329876-4cgrjnjo	284	3	replaced	replace	VBN
cord-329876-4cgrjnjo	284	4	by	by	IN
cord-329876-4cgrjnjo	284	5	Gly	Gly	NNP
cord-329876-4cgrjnjo	284	6	in	in	IN
cord-329876-4cgrjnjo	284	7	SARS	SARS	NNP
cord-329876-4cgrjnjo	284	8	-	-	HYPH
cord-329876-4cgrjnjo	284	9	CoV	CoV	NNP
cord-329876-4cgrjnjo	284	10	PL	PL	NNP
cord-329876-4cgrjnjo	284	11	pro	pro	NNP
cord-329876-4cgrjnjo	284	12	and	and	CC
cord-329876-4cgrjnjo	284	13	the	the	DT
cord-329876-4cgrjnjo	284	14	PL2	PL2	NNP
cord-329876-4cgrjnjo	284	15	pro	pro	NNP
cord-329876-4cgrjnjo	284	16	s	s	NNP
cord-329876-4cgrjnjo	284	17	of	of	IN
cord-329876-4cgrjnjo	285	1	HCoV	HCoV	NNP
cord-329876-4cgrjnjo	285	2	NL63	NL63	NNP
cord-329876-4cgrjnjo	285	3	and	and	CC
cord-329876-4cgrjnjo	285	4	HCoV	HCoV	NNP
cord-329876-4cgrjnjo	285	5	229E	229e	CD
cord-329876-4cgrjnjo	285	6	,	,	,
cord-329876-4cgrjnjo	285	7	by	by	IN
cord-329876-4cgrjnjo	285	8	Ala	Ala	NNP
cord-329876-4cgrjnjo	285	9	in	in	IN
cord-329876-4cgrjnjo	285	10	HCoV	HCoV	NNP
cord-329876-4cgrjnjo	285	11	-	-	HYPH
cord-329876-4cgrjnjo	285	12	OC43	OC43	NNP
cord-329876-4cgrjnjo	285	13	PL2	PL2	NNP
cord-329876-4cgrjnjo	285	14	pro	pro	JJ
cord-329876-4cgrjnjo	285	15	,	,	,
cord-329876-4cgrjnjo	285	16	and	and	CC
cord-329876-4cgrjnjo	285	17	by	by	IN
cord-329876-4cgrjnjo	285	18	Ser	Ser	NNP
cord-329876-4cgrjnjo	285	19	in	in	IN
cord-329876-4cgrjnjo	285	20	HCoV	HCoV	NNP
cord-329876-4cgrjnjo	285	21	-	-	HYPH
cord-329876-4cgrjnjo	285	22	HKU1	HKU1	NNP
cord-329876-4cgrjnjo	285	23	PL2	PL2	NNP
cord-329876-4cgrjnjo	285	24	pro	pro	JJ
cord-329876-4cgrjnjo	285	25	.	.	.
cord-329876-4cgrjnjo	286	1	Our	-PRON-	PRP$
cord-329876-4cgrjnjo	286	2	kinetic	kinetic	JJ
cord-329876-4cgrjnjo	286	3	results	result	NNS
cord-329876-4cgrjnjo	286	4	for	for	IN
cord-329876-4cgrjnjo	286	5	the	the	DT
cord-329876-4cgrjnjo	286	6	D164A	D164A	NNPS
cord-329876-4cgrjnjo	286	7	replacement	replacement	NN
cord-329876-4cgrjnjo	286	8	(	(	-LRB-
cord-329876-4cgrjnjo	286	9	see	see	VB
cord-329876-4cgrjnjo	286	10	Results	result	NNS
cord-329876-4cgrjnjo	286	11	)	)	-RRB-
cord-329876-4cgrjnjo	286	12	emphasize	emphasize	VBP
cord-329876-4cgrjnjo	286	13	the	the	DT
cord-329876-4cgrjnjo	286	14	importance	importance	NN
cord-329876-4cgrjnjo	286	15	of	of	IN
cord-329876-4cgrjnjo	286	16	the	the	DT
cord-329876-4cgrjnjo	286	17	unique	unique	JJ
cord-329876-4cgrjnjo	286	18	Asp164	asp164	CD
cord-329876-4cgrjnjo	286	19	residue	residue	NN
cord-329876-4cgrjnjo	286	20	.	.	.
cord-329876-4cgrjnjo	287	1	In	in	IN
cord-329876-4cgrjnjo	287	2	our	-PRON-	PRP$
cord-329876-4cgrjnjo	287	3	PL	pl	NN
cord-329876-4cgrjnjo	287	4	pro	pro	FW
cord-329876-4cgrjnjo	287	5	(	(	-LRB-
cord-329876-4cgrjnjo	287	6	C111S)-Ub	c111s)-ub	NN
cord-329876-4cgrjnjo	287	7	complex	complex	NN
cord-329876-4cgrjnjo	287	8	,	,	,
cord-329876-4cgrjnjo	287	9	the	the	DT
cord-329876-4cgrjnjo	287	10	Ubl	Ubl	NNP
cord-329876-4cgrjnjo	287	11	domain	domain	NN
cord-329876-4cgrjnjo	287	12	of	of	IN
cord-329876-4cgrjnjo	287	13	PL	pl	NN
cord-329876-4cgrjnjo	287	14	pro	pro	NN
cord-329876-4cgrjnjo	287	15	shows	show	VBZ
cord-329876-4cgrjnjo	287	16	no	no	DT
cord-329876-4cgrjnjo	287	17	interaction	interaction	NN
cord-329876-4cgrjnjo	287	18	with	with	IN
cord-329876-4cgrjnjo	287	19	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	287	20	.	.	.
cord-329876-4cgrjnjo	288	1	The	the	DT
cord-329876-4cgrjnjo	288	2	relative	relative	JJ
cord-329876-4cgrjnjo	288	3	orientation	orientation	NN
cord-329876-4cgrjnjo	288	4	of	of	IN
cord-329876-4cgrjnjo	288	5	the	the	DT
cord-329876-4cgrjnjo	288	6	Ubl	Ubl	NNP
cord-329876-4cgrjnjo	288	7	domain	domain	NN
cord-329876-4cgrjnjo	288	8	in	in	IN
cord-329876-4cgrjnjo	288	9	the	the	DT
cord-329876-4cgrjnjo	288	10	substrate	substrate	NN
cord-329876-4cgrjnjo	288	11	-	-	HYPH
cord-329876-4cgrjnjo	288	12	bound	bind	VBN
cord-329876-4cgrjnjo	288	13	PL	pl	NN
cord-329876-4cgrjnjo	288	14	pro	pro	NN
cord-329876-4cgrjnjo	288	15	is	be	VBZ
cord-329876-4cgrjnjo	288	16	the	the	DT
cord-329876-4cgrjnjo	288	17	same	same	JJ
cord-329876-4cgrjnjo	288	18	as	as	IN
cord-329876-4cgrjnjo	288	19	in	in	IN
cord-329876-4cgrjnjo	288	20	substrate	substrate	NN
cord-329876-4cgrjnjo	288	21	-	-	HYPH
cord-329876-4cgrjnjo	288	22	free	free	JJ
cord-329876-4cgrjnjo	288	23	PL	pl	NN
cord-329876-4cgrjnjo	288	24	pro	pro	NN
cord-329876-4cgrjnjo	288	25	.	.	.
cord-329876-4cgrjnjo	289	1	The	the	DT
cord-329876-4cgrjnjo	289	2	Ubl	Ubl	NNP
cord-329876-4cgrjnjo	289	3	domain	domain	NN
cord-329876-4cgrjnjo	289	4	of	of	IN
cord-329876-4cgrjnjo	289	5	MERS	MERS	NNP
cord-329876-4cgrjnjo	289	6	-	-	HYPH
cord-329876-4cgrjnjo	289	7	CoV	CoV	NNP
cord-329876-4cgrjnjo	289	8	PL	pl	NN
cord-329876-4cgrjnjo	289	9	pro	pro	NNP
cord-329876-4cgrjnjo	289	10	is	be	VBZ
cord-329876-4cgrjnjo	289	11	not	not	RB
cord-329876-4cgrjnjo	289	12	required	require	VBN
cord-329876-4cgrjnjo	289	13	for	for	IN
cord-329876-4cgrjnjo	289	14	the	the	DT
cord-329876-4cgrjnjo	289	15	IFN	IFN	NNP
cord-329876-4cgrjnjo	289	16	antagonism	antagonism	NN
cord-329876-4cgrjnjo	289	17	activities	activity	NNS
cord-329876-4cgrjnjo	289	18	(	(	-LRB-
cord-329876-4cgrjnjo	289	19	Baez	Baez	NNP
cord-329876-4cgrjnjo	289	20	-	-	HYPH
cord-329876-4cgrjnjo	289	21	Santos	Santos	NNP
cord-329876-4cgrjnjo	289	22	et	et	NNP
cord-329876-4cgrjnjo	289	23	al	al	NNP
cord-329876-4cgrjnjo	289	24	.	.	NNP
cord-329876-4cgrjnjo	289	25	,	,	,
cord-329876-4cgrjnjo	289	26	2014b	2014b	CD
cord-329876-4cgrjnjo	289	27	)	)	-RRB-
cord-329876-4cgrjnjo	289	28	,	,	,
cord-329876-4cgrjnjo	289	29	but	but	CC
cord-329876-4cgrjnjo	289	30	it	-PRON-	PRP
cord-329876-4cgrjnjo	289	31	is	be	VBZ
cord-329876-4cgrjnjo	289	32	required	require	VBN
cord-329876-4cgrjnjo	289	33	in	in	IN
cord-329876-4cgrjnjo	289	34	case	case	NN
cord-329876-4cgrjnjo	289	35	of	of	IN
cord-329876-4cgrjnjo	289	36	SARS	SARS	NNP
cord-329876-4cgrjnjo	289	37	-	-	HYPH
cord-329876-4cgrjnjo	289	38	CoV	CoV	NNP
cord-329876-4cgrjnjo	289	39	PL	pl	NN
cord-329876-4cgrjnjo	289	40	pro	pro	JJ
cord-329876-4cgrjnjo	289	41	(	(	-LRB-
cord-329876-4cgrjnjo	289	42	Frieman	Frieman	NNP
cord-329876-4cgrjnjo	289	43	et	et	FW
cord-329876-4cgrjnjo	289	44	al	al	NNP
cord-329876-4cgrjnjo	289	45	.	.	NNP
cord-329876-4cgrjnjo	289	46	,	,	,
cord-329876-4cgrjnjo	289	47	2009	2009	CD
cord-329876-4cgrjnjo	289	48	)	)	-RRB-
cord-329876-4cgrjnjo	289	49	.	.	.
cord-329876-4cgrjnjo	290	1	Recently	recently	RB
cord-329876-4cgrjnjo	290	2	,	,	,
cord-329876-4cgrjnjo	290	3	Mielech	Mielech	NNP
cord-329876-4cgrjnjo	290	4	et	et	NNP
cord-329876-4cgrjnjo	290	5	al	al	NNP
cord-329876-4cgrjnjo	290	6	.	.	.
cord-329876-4cgrjnjo	291	1	(	(	-LRB-
cord-329876-4cgrjnjo	291	2	2015	2015	CD
cord-329876-4cgrjnjo	291	3	)	)	-RRB-
cord-329876-4cgrjnjo	291	4	reported	report	VBD
cord-329876-4cgrjnjo	291	5	that	that	IN
cord-329876-4cgrjnjo	291	6	the	the	DT
cord-329876-4cgrjnjo	291	7	Ubl	Ubl	NNP
cord-329876-4cgrjnjo	291	8	domain	domain	NN
cord-329876-4cgrjnjo	291	9	of	of	IN
cord-329876-4cgrjnjo	291	10	mouse	mouse	NN
cord-329876-4cgrjnjo	291	11	hepatitis	hepatitis	NN
cord-329876-4cgrjnjo	291	12	virus	virus	NN
cord-329876-4cgrjnjo	291	13	(	(	-LRB-
cord-329876-4cgrjnjo	291	14	MHV	MHV	NNP
cord-329876-4cgrjnjo	291	15	)	)	-RRB-
cord-329876-4cgrjnjo	291	16	is	be	VBZ
cord-329876-4cgrjnjo	291	17	an	an	DT
cord-329876-4cgrjnjo	291	18	important	important	JJ
cord-329876-4cgrjnjo	291	19	modulator	modulator	NN
cord-329876-4cgrjnjo	291	20	of	of	IN
cord-329876-4cgrjnjo	291	21	PL	pl	NN
cord-329876-4cgrjnjo	291	22	pro	pro	JJ
cord-329876-4cgrjnjo	291	23	stability	stability	NN
cord-329876-4cgrjnjo	291	24	and	and	CC
cord-329876-4cgrjnjo	291	25	viral	viral	JJ
cord-329876-4cgrjnjo	291	26	pathogenesis	pathogenesis	NN
cord-329876-4cgrjnjo	291	27	.	.	.
cord-329876-4cgrjnjo	292	1	Although	although	IN
cord-329876-4cgrjnjo	292	2	the	the	DT
cord-329876-4cgrjnjo	292	3	Ubl	Ubl	NNP
cord-329876-4cgrjnjo	292	4	domain	domain	NN
cord-329876-4cgrjnjo	292	5	shows	show	VBZ
cord-329876-4cgrjnjo	292	6	variable	variable	JJ
cord-329876-4cgrjnjo	292	7	effects	effect	NNS
cord-329876-4cgrjnjo	292	8	in	in	IN
cord-329876-4cgrjnjo	292	9	different	different	JJ
cord-329876-4cgrjnjo	292	10	CoVs	covs	NN
cord-329876-4cgrjnjo	292	11	,	,	,
cord-329876-4cgrjnjo	292	12	the	the	DT
cord-329876-4cgrjnjo	292	13	high	high	JJ
cord-329876-4cgrjnjo	292	14	degree	degree	NN
cord-329876-4cgrjnjo	292	15	of	of	IN
cord-329876-4cgrjnjo	292	16	conservation	conservation	NN
cord-329876-4cgrjnjo	292	17	of	of	IN
cord-329876-4cgrjnjo	292	18	the	the	DT
cord-329876-4cgrjnjo	292	19	domain	domain	NN
cord-329876-4cgrjnjo	292	20	throughout	throughout	IN
cord-329876-4cgrjnjo	292	21	the	the	DT
cord-329876-4cgrjnjo	292	22	family	family	NN
cord-329876-4cgrjnjo	292	23	suggests	suggest	VBZ
cord-329876-4cgrjnjo	292	24	that	that	IN
cord-329876-4cgrjnjo	292	25	it	-PRON-	PRP
cord-329876-4cgrjnjo	292	26	may	may	MD
cord-329876-4cgrjnjo	292	27	play	play	VB
cord-329876-4cgrjnjo	292	28	a	a	DT
cord-329876-4cgrjnjo	292	29	common	common	JJ
cord-329876-4cgrjnjo	292	30	biological	biological	JJ
cord-329876-4cgrjnjo	292	31	role	role	NN
cord-329876-4cgrjnjo	292	32	.	.	.
cord-329876-4cgrjnjo	293	1	One	one	CD
cord-329876-4cgrjnjo	293	2	possible	possible	JJ
cord-329876-4cgrjnjo	293	3	function	function	NN
cord-329876-4cgrjnjo	293	4	is	be	VBZ
cord-329876-4cgrjnjo	293	5	that	that	IN
cord-329876-4cgrjnjo	293	6	the	the	DT
cord-329876-4cgrjnjo	293	7	Ubl	Ubl	NNP
cord-329876-4cgrjnjo	293	8	might	may	MD
cord-329876-4cgrjnjo	293	9	be	be	VB
cord-329876-4cgrjnjo	293	10	involved	involve	VBN
cord-329876-4cgrjnjo	293	11	in	in	IN
cord-329876-4cgrjnjo	293	12	protein	protein	NN
cord-329876-4cgrjnjo	293	13	-	-	HYPH
cord-329876-4cgrjnjo	293	14	protein	protein	NN
cord-329876-4cgrjnjo	293	15	interactions	interaction	NNS
cord-329876-4cgrjnjo	293	16	.	.	.
cord-329876-4cgrjnjo	294	1	Ubiquitin	Ubiquitin	NNP
cord-329876-4cgrjnjo	294	2	-	-	HYPH
cord-329876-4cgrjnjo	294	3	like	like	JJ
cord-329876-4cgrjnjo	294	4	domains	domain	NNS
cord-329876-4cgrjnjo	294	5	are	be	VBP
cord-329876-4cgrjnjo	294	6	known	know	VBN
cord-329876-4cgrjnjo	294	7	to	to	TO
cord-329876-4cgrjnjo	294	8	function	function	VB
cord-329876-4cgrjnjo	294	9	as	as	IN
cord-329876-4cgrjnjo	294	10	binding	bind	VBG
cord-329876-4cgrjnjo	294	11	modules	module	NNS
cord-329876-4cgrjnjo	294	12	in	in	IN
cord-329876-4cgrjnjo	294	13	such	such	JJ
cord-329876-4cgrjnjo	294	14	interactions	interaction	NNS
cord-329876-4cgrjnjo	294	15	.	.	.
cord-329876-4cgrjnjo	295	1	For	for	IN
cord-329876-4cgrjnjo	295	2	example	example	NN
cord-329876-4cgrjnjo	295	3	,	,	,
cord-329876-4cgrjnjo	295	4	the	the	DT
cord-329876-4cgrjnjo	295	5	kinase	kinase	NN
cord-329876-4cgrjnjo	295	6	Raf	Raf	NNP
cord-329876-4cgrjnjo	295	7	contains	contain	VBZ
cord-329876-4cgrjnjo	295	8	a	a	DT
cord-329876-4cgrjnjo	295	9	Ubl	Ubl	NNP
cord-329876-4cgrjnjo	295	10	domain	domain	NN
cord-329876-4cgrjnjo	295	11	for	for	IN
cord-329876-4cgrjnjo	295	12	interaction	interaction	NN
cord-329876-4cgrjnjo	295	13	with	with	IN
cord-329876-4cgrjnjo	295	14	human	human	JJ
cord-329876-4cgrjnjo	295	15	Ras	Ras	NNP
cord-329876-4cgrjnjo	295	16	(	(	-LRB-
cord-329876-4cgrjnjo	295	17	Fetics	Fetics	NNP
cord-329876-4cgrjnjo	295	18	et	et	NNP
cord-329876-4cgrjnjo	295	19	al	al	NNP
cord-329876-4cgrjnjo	295	20	.	.	NNP
cord-329876-4cgrjnjo	295	21	,	,	,
cord-329876-4cgrjnjo	295	22	2015	2015	CD
cord-329876-4cgrjnjo	295	23	)	)	-RRB-
cord-329876-4cgrjnjo	295	24	.	.	.
cord-329876-4cgrjnjo	296	1	Also	also	RB
cord-329876-4cgrjnjo	296	2	,	,	,
cord-329876-4cgrjnjo	296	3	human	human	JJ
cord-329876-4cgrjnjo	296	4	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	296	5	-	-	HYPH
cord-329876-4cgrjnjo	296	6	specific	specific	JJ
cord-329876-4cgrjnjo	296	7	protease	protease	NN
cord-329876-4cgrjnjo	296	8	(	(	-LRB-
cord-329876-4cgrjnjo	296	9	USP	USP	NNP
cord-329876-4cgrjnjo	296	10	)	)	-RRB-
cord-329876-4cgrjnjo	296	11	7	7	CD
cord-329876-4cgrjnjo	296	12	includes	include	VBZ
cord-329876-4cgrjnjo	296	13	five	five	CD
cord-329876-4cgrjnjo	296	14	Ubl	Ubl	NNP
cord-329876-4cgrjnjo	296	15	(	(	-LRB-
cord-329876-4cgrjnjo	296	16	1	1	CD
cord-329876-4cgrjnjo	296	17	-	-	SYM
cord-329876-4cgrjnjo	296	18	5	5	CD
cord-329876-4cgrjnjo	296	19	)	)	-RRB-
cord-329876-4cgrjnjo	296	20	domains	domain	NNS
cord-329876-4cgrjnjo	296	21	,	,	,
cord-329876-4cgrjnjo	296	22	of	of	IN
cord-329876-4cgrjnjo	296	23	which	which	WDT
cord-329876-4cgrjnjo	296	24	the	the	DT
cord-329876-4cgrjnjo	296	25	second	second	JJ
cord-329876-4cgrjnjo	296	26	is	be	VBZ
cord-329876-4cgrjnjo	296	27	bound	bind	VBN
cord-329876-4cgrjnjo	296	28	by	by	IN
cord-329876-4cgrjnjo	296	29	the	the	DT
cord-329876-4cgrjnjo	296	30	Herpes	Herpes	NNP
cord-329876-4cgrjnjo	296	31	simplex	simplex	NN
cord-329876-4cgrjnjo	296	32	virus-1	virus-1	NN
cord-329876-4cgrjnjo	296	33	immediate	immediate	JJ
cord-329876-4cgrjnjo	296	34	-	-	HYPH
cord-329876-4cgrjnjo	296	35	early	early	JJ
cord-329876-4cgrjnjo	296	36	protein	protein	NN
cord-329876-4cgrjnjo	296	37	ICP0	ICP0	NNP
cord-329876-4cgrjnjo	296	38	to	to	TO
cord-329876-4cgrjnjo	296	39	counteract	counteract	VB
cord-329876-4cgrjnjo	296	40	the	the	DT
cord-329876-4cgrjnjo	296	41	intrinsic	intrinsic	JJ
cord-329876-4cgrjnjo	296	42	antiviral	antiviral	JJ
cord-329876-4cgrjnjo	296	43	response	response	NN
cord-329876-4cgrjnjo	296	44	of	of	IN
cord-329876-4cgrjnjo	296	45	the	the	DT
cord-329876-4cgrjnjo	296	46	host	host	NN
cord-329876-4cgrjnjo	296	47	cell	cell	NN
cord-329876-4cgrjnjo	296	48	(	(	-LRB-
cord-329876-4cgrjnjo	296	49	Pfoh	Pfoh	NNP
cord-329876-4cgrjnjo	296	50	et	et	NNP
cord-329876-4cgrjnjo	296	51	al	al	NNP
cord-329876-4cgrjnjo	296	52	.	.	NNP
cord-329876-4cgrjnjo	296	53	,	,	,
cord-329876-4cgrjnjo	296	54	2015	2015	CD
cord-329876-4cgrjnjo	296	55	)	)	-RRB-
cord-329876-4cgrjnjo	296	56	.	.	.
cord-329876-4cgrjnjo	297	1	The	the	DT
cord-329876-4cgrjnjo	297	2	BL2	bl2	NN
cord-329876-4cgrjnjo	297	3	loop	loop	NN
cord-329876-4cgrjnjo	297	4	of	of	IN
cord-329876-4cgrjnjo	297	5	SARS	SARS	NNP
cord-329876-4cgrjnjo	297	6	-	-	HYPH
cord-329876-4cgrjnjo	297	7	CoV	CoV	NNP
cord-329876-4cgrjnjo	297	8	PL	pl	NN
cord-329876-4cgrjnjo	297	9	pro	pro	NNP
cord-329876-4cgrjnjo	297	10	is	be	VBZ
cord-329876-4cgrjnjo	297	11	important	important	JJ
cord-329876-4cgrjnjo	297	12	for	for	IN
cord-329876-4cgrjnjo	297	13	binding	bind	VBG
cord-329876-4cgrjnjo	297	14	inhibitors	inhibitor	NNS
cord-329876-4cgrjnjo	297	15	(	(	-LRB-
cord-329876-4cgrjnjo	297	16	Baez	Baez	NNP
cord-329876-4cgrjnjo	297	17	-	-	HYPH
cord-329876-4cgrjnjo	297	18	Santos	Santos	NNP
cord-329876-4cgrjnjo	297	19	et	et	FW
cord-329876-4cgrjnjo	297	20	al	al	NNP
cord-329876-4cgrjnjo	297	21	.	.	.
cord-329876-4cgrjnjo	298	1	,	,	,
cord-329876-4cgrjnjo	298	2	2014a	2014a	CD
cord-329876-4cgrjnjo	298	3	;	;	:
cord-329876-4cgrjnjo	298	4	Lee	Lee	NNP
cord-329876-4cgrjnjo	298	5	et	et	NNP
cord-329876-4cgrjnjo	298	6	al	al	NNP
cord-329876-4cgrjnjo	298	7	.	.	NNP
cord-329876-4cgrjnjo	298	8	,	,	,
cord-329876-4cgrjnjo	298	9	2015	2015	CD
cord-329876-4cgrjnjo	298	10	)	)	-RRB-
cord-329876-4cgrjnjo	298	11	.	.	.
cord-329876-4cgrjnjo	299	1	This	this	DT
cord-329876-4cgrjnjo	299	2	loop	loop	NN
cord-329876-4cgrjnjo	299	3	is	be	VBZ
cord-329876-4cgrjnjo	299	4	variable	variable	JJ
cord-329876-4cgrjnjo	299	5	in	in	IN
cord-329876-4cgrjnjo	299	6	different	different	JJ
cord-329876-4cgrjnjo	299	7	CoV	cov	NN
cord-329876-4cgrjnjo	299	8	PL	pl	NN
cord-329876-4cgrjnjo	299	9	pro	pro	JJ
cord-329876-4cgrjnjo	300	1	s.	s.	NNP
cord-329876-4cgrjnjo	300	2	A	a	DT
cord-329876-4cgrjnjo	300	3	potent	potent	JJ
cord-329876-4cgrjnjo	300	4	inhibitor	inhibitor	NN
cord-329876-4cgrjnjo	300	5	of	of	IN
cord-329876-4cgrjnjo	300	6	the	the	DT
cord-329876-4cgrjnjo	300	7	SARS	SARS	NNP
cord-329876-4cgrjnjo	300	8	-	-	HYPH
cord-329876-4cgrjnjo	300	9	CoV	CoV	NNP
cord-329876-4cgrjnjo	300	10	PL	PL	NNP
cord-329876-4cgrjnjo	300	11	pro	pro	NNP
cord-329876-4cgrjnjo	300	12	,	,	,
cord-329876-4cgrjnjo	300	13	N-[(3-fluorophenyl	n-[(3-fluorophenyl	NN
cord-329876-4cgrjnjo	300	14	)	)	-RRB-
cord-329876-4cgrjnjo	300	15	methyl]-1-[(1R)-1-naphthalen-1-ylethyl	methyl]-1-[(1R)-1-naphthalen-1-ylethyl	NNP
cord-329876-4cgrjnjo	300	16	]	]	-RRB-
cord-329876-4cgrjnjo	300	17	piperidine-4-carboxamide	piperidine-4-carboxamide	NNP
cord-329876-4cgrjnjo	300	18	(	(	-LRB-
cord-329876-4cgrjnjo	300	19	compound	compound	NN
cord-329876-4cgrjnjo	300	20	3k	3k	CD
cord-329876-4cgrjnjo	300	21	,	,	,
cord-329876-4cgrjnjo	300	22	IC	IC	NNP
cord-329876-4cgrjnjo	300	23	50	50	CD
cord-329876-4cgrjnjo	301	1	=	=	NFP
cord-329876-4cgrjnjo	301	2	0.15	0.15	CD
cord-329876-4cgrjnjo	301	3	±	±	CD
cord-329876-4cgrjnjo	301	4	0.01	0.01	CD
cord-329876-4cgrjnjo	301	5	μmol	μmol	NNP
cord-329876-4cgrjnjo	301	6	/	/	SYM
cord-329876-4cgrjnjo	301	7	L	L	NNP
cord-329876-4cgrjnjo	301	8	)	)	-RRB-
cord-329876-4cgrjnjo	301	9	was	be	VBD
cord-329876-4cgrjnjo	301	10	found	find	VBN
cord-329876-4cgrjnjo	301	11	to	to	TO
cord-329876-4cgrjnjo	301	12	have	have	VB
cord-329876-4cgrjnjo	301	13	no	no	DT
cord-329876-4cgrjnjo	301	14	effect	effect	NN
cord-329876-4cgrjnjo	301	15	on	on	IN
cord-329876-4cgrjnjo	301	16	the	the	DT
cord-329876-4cgrjnjo	301	17	MERS	MERS	NNP
cord-329876-4cgrjnjo	301	18	-	-	HYPH
cord-329876-4cgrjnjo	301	19	CoV	CoV	NNP
cord-329876-4cgrjnjo	301	20	enzyme	enzyme	NN
cord-329876-4cgrjnjo	302	1	(	(	-LRB-
cord-329876-4cgrjnjo	302	2	Baez	Baez	NNP
cord-329876-4cgrjnjo	302	3	-	-	HYPH
cord-329876-4cgrjnjo	302	4	Santos	Santos	NNP
cord-329876-4cgrjnjo	302	5	et	et	NNP
cord-329876-4cgrjnjo	302	6	al	al	NNP
cord-329876-4cgrjnjo	302	7	.	.	NNP
cord-329876-4cgrjnjo	302	8	,	,	,
cord-329876-4cgrjnjo	302	9	2014b	2014b	CD
cord-329876-4cgrjnjo	302	10	)	)	-RRB-
cord-329876-4cgrjnjo	302	11	.	.	.
cord-329876-4cgrjnjo	303	1	Tyr269	Tyr269	NNP
cord-329876-4cgrjnjo	303	2	and	and	CC
cord-329876-4cgrjnjo	303	3	Gln270	gln270	DT
cord-329876-4cgrjnjo	303	4	of	of	IN
cord-329876-4cgrjnjo	303	5	SARS	SARS	NNP
cord-329876-4cgrjnjo	303	6	-	-	HYPH
cord-329876-4cgrjnjo	303	7	CoV	CoV	NNP
cord-329876-4cgrjnjo	303	8	PL	PL	NNP
cord-329876-4cgrjnjo	303	9	pro	pro	NNP
cord-329876-4cgrjnjo	303	10	,	,	,
cord-329876-4cgrjnjo	303	11	which	which	WDT
cord-329876-4cgrjnjo	303	12	are	be	VBP
cord-329876-4cgrjnjo	303	13	important	important	JJ
cord-329876-4cgrjnjo	303	14	for	for	IN
cord-329876-4cgrjnjo	303	15	binding	bind	VBG
cord-329876-4cgrjnjo	303	16	this	this	DT
cord-329876-4cgrjnjo	303	17	inhibitor	inhibitor	NN
cord-329876-4cgrjnjo	303	18	(	(	-LRB-
cord-329876-4cgrjnjo	303	19	Baez	Baez	NNP
cord-329876-4cgrjnjo	303	20	-	-	HYPH
cord-329876-4cgrjnjo	303	21	Santos	Santos	NNP
cord-329876-4cgrjnjo	303	22	et	et	NNP
cord-329876-4cgrjnjo	303	23	al	al	NNP
cord-329876-4cgrjnjo	303	24	.	.	NNP
cord-329876-4cgrjnjo	303	25	,	,	,
cord-329876-4cgrjnjo	303	26	2014a	2014a	CD
cord-329876-4cgrjnjo	303	27	)	)	-RRB-
cord-329876-4cgrjnjo	303	28	,	,	,
cord-329876-4cgrjnjo	303	29	are	be	VBP
cord-329876-4cgrjnjo	303	30	replaced	replace	VBN
cord-329876-4cgrjnjo	303	31	by	by	IN
cord-329876-4cgrjnjo	303	32	Glu273	glu273	ADD
cord-329876-4cgrjnjo	304	1	and	and	CC
cord-329876-4cgrjnjo	304	2	Ala275	Ala275	NFP
cord-329876-4cgrjnjo	304	3	in	in	IN
cord-329876-4cgrjnjo	304	4	the	the	DT
cord-329876-4cgrjnjo	304	5	MERS	MERS	NNP
cord-329876-4cgrjnjo	304	6	-	-	HYPH
cord-329876-4cgrjnjo	304	7	CoV	CoV	NNP
cord-329876-4cgrjnjo	304	8	protease	protease	NN
cord-329876-4cgrjnjo	304	9	.	.	.
cord-329876-4cgrjnjo	305	1	It	-PRON-	PRP
cord-329876-4cgrjnjo	305	2	seems	seem	VBZ
cord-329876-4cgrjnjo	305	3	that	that	IN
cord-329876-4cgrjnjo	305	4	this	this	DT
cord-329876-4cgrjnjo	305	5	structural	structural	JJ
cord-329876-4cgrjnjo	305	6	difference	difference	NN
cord-329876-4cgrjnjo	305	7	in	in	IN
cord-329876-4cgrjnjo	305	8	the	the	DT
cord-329876-4cgrjnjo	305	9	BL2	BL2	NNP
cord-329876-4cgrjnjo	305	10	loop	loop	NN
cord-329876-4cgrjnjo	305	11	has	have	VBZ
cord-329876-4cgrjnjo	305	12	a	a	DT
cord-329876-4cgrjnjo	305	13	remarkable	remarkable	JJ
cord-329876-4cgrjnjo	305	14	impact	impact	NN
cord-329876-4cgrjnjo	305	15	on	on	IN
cord-329876-4cgrjnjo	305	16	the	the	DT
cord-329876-4cgrjnjo	305	17	effectiveness	effectiveness	NN
cord-329876-4cgrjnjo	305	18	of	of	IN
cord-329876-4cgrjnjo	305	19	the	the	DT
cord-329876-4cgrjnjo	305	20	inhibitor	inhibitor	NN
cord-329876-4cgrjnjo	305	21	.	.	.
cord-329876-4cgrjnjo	306	1	The	the	DT
cord-329876-4cgrjnjo	306	2	structure	structure	NN
cord-329876-4cgrjnjo	306	3	of	of	IN
cord-329876-4cgrjnjo	306	4	the	the	DT
cord-329876-4cgrjnjo	306	5	MERS	MERS	NNP
cord-329876-4cgrjnjo	306	6	-	-	HYPH
cord-329876-4cgrjnjo	306	7	CoV	cov	NN
cord-329876-4cgrjnjo	306	8	PL	pl	NN
cord-329876-4cgrjnjo	306	9	pro	pro	JJ
cord-329876-4cgrjnjo	306	10	(	(	-LRB-
cord-329876-4cgrjnjo	306	11	C111S)-Ub	c111s)-ub	NN
cord-329876-4cgrjnjo	306	12	complex	complex	NN
cord-329876-4cgrjnjo	306	13	presented	present	VBN
cord-329876-4cgrjnjo	306	14	here	here	RB
cord-329876-4cgrjnjo	306	15	will	will	MD
cord-329876-4cgrjnjo	306	16	facilitate	facilitate	VB
cord-329876-4cgrjnjo	306	17	virtual	virtual	JJ
cord-329876-4cgrjnjo	306	18	screening	screening	NN
cord-329876-4cgrjnjo	306	19	of	of	IN
cord-329876-4cgrjnjo	306	20	chemical	chemical	JJ
cord-329876-4cgrjnjo	306	21	libraries	library	NNS
cord-329876-4cgrjnjo	306	22	for	for	IN
cord-329876-4cgrjnjo	306	23	specific	specific	JJ
cord-329876-4cgrjnjo	306	24	anti	anti	JJ
cord-329876-4cgrjnjo	306	25	-MERS	-mers	JJ
cord-329876-4cgrjnjo	306	26	-	-	HYPH
cord-329876-4cgrjnjo	306	27	CoV	cov	NN
cord-329876-4cgrjnjo	306	28	PL	pl	NN
cord-329876-4cgrjnjo	306	29	pro	pro	JJ
cord-329876-4cgrjnjo	306	30	inhibitors	inhibitor	NNS
cord-329876-4cgrjnjo	306	31	(	(	-LRB-
cord-329876-4cgrjnjo	306	32	Hilgenfeld	Hilgenfeld	NNP
cord-329876-4cgrjnjo	306	33	,	,	,
cord-329876-4cgrjnjo	306	34	2014	2014	CD
cord-329876-4cgrjnjo	306	35	)	)	-RRB-
cord-329876-4cgrjnjo	306	36	.	.	.
cord-329876-4cgrjnjo	307	1	The	the	DT
cord-329876-4cgrjnjo	307	2	di	di	FW
cord-329876-4cgrjnjo	307	3	-	-	HYPH
cord-329876-4cgrjnjo	307	4	Ub	ub	JJ
cord-329876-4cgrjnjo	307	5	site	site	NN
cord-329876-4cgrjnjo	307	6	of	of	IN
cord-329876-4cgrjnjo	307	7	PL	pl	NN
cord-329876-4cgrjnjo	307	8	pro	pro	JJ
cord-329876-4cgrjnjo	307	9	SARS	SARS	NNP
cord-329876-4cgrjnjo	307	10	-	-	HYPH
cord-329876-4cgrjnjo	307	11	CoV	CoV	NNP
cord-329876-4cgrjnjo	307	12	and	and	CC
cord-329876-4cgrjnjo	307	13	MERS	MERS	NNP
cord-329876-4cgrjnjo	307	14	-	-	HYPH
cord-329876-4cgrjnjo	307	15	CoV	CoV	NNP
cord-329876-4cgrjnjo	307	16	PL	pl	NN
cord-329876-4cgrjnjo	307	17	pro	pro	NNP
cord-329876-4cgrjnjo	307	18	s	s	NN
cord-329876-4cgrjnjo	307	19	can	can	MD
cord-329876-4cgrjnjo	307	20	digest	digest	VB
cord-329876-4cgrjnjo	308	1	K48-and	K48-and	NNP
cord-329876-4cgrjnjo	308	2	K63-linked	K63-linked	NNP
cord-329876-4cgrjnjo	309	1	(	(	-LRB-
cord-329876-4cgrjnjo	309	2	poly)ubiquitin	poly)ubiquitin	NNP
cord-329876-4cgrjnjo	309	3	chains	chain	NNS
cord-329876-4cgrjnjo	309	4	and	and	CC
cord-329876-4cgrjnjo	309	5	remove	remove	VB
cord-329876-4cgrjnjo	309	6	ISG15	isg15	NN
cord-329876-4cgrjnjo	309	7	from	from	IN
cord-329876-4cgrjnjo	309	8	proteins	protein	NNS
cord-329876-4cgrjnjo	309	9	covalently	covalently	RB
cord-329876-4cgrjnjo	309	10	linked	link	VBN
cord-329876-4cgrjnjo	309	11	to	to	IN
cord-329876-4cgrjnjo	309	12	it	-PRON-	PRP
cord-329876-4cgrjnjo	310	1	(	(	-LRB-
cord-329876-4cgrjnjo	310	2	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	310	3	et	et	NNP
cord-329876-4cgrjnjo	310	4	al	al	NNP
cord-329876-4cgrjnjo	310	5	.	.	NNP
cord-329876-4cgrjnjo	310	6	,	,	,
cord-329876-4cgrjnjo	311	1	2014	2014	CD
cord-329876-4cgrjnjo	311	2	,	,	,
cord-329876-4cgrjnjo	311	3	Baez	Baez	NNP
cord-329876-4cgrjnjo	311	4	-	-	HYPH
cord-329876-4cgrjnjo	311	5	Santos	Santos	NNP
cord-329876-4cgrjnjo	311	6	et	et	NNP
cord-329876-4cgrjnjo	311	7	al	al	NNP
cord-329876-4cgrjnjo	311	8	.	.	NNP
cord-329876-4cgrjnjo	311	9	,	,	,
cord-329876-4cgrjnjo	311	10	2014b	2014b	CD
cord-329876-4cgrjnjo	311	11	.	.	.
cord-329876-4cgrjnjo	312	1	SARS	SARS	NNP
cord-329876-4cgrjnjo	312	2	-	-	HYPH
cord-329876-4cgrjnjo	312	3	CoV	CoV	NNP
cord-329876-4cgrjnjo	312	4	PL	pl	NN
cord-329876-4cgrjnjo	312	5	pro	pro	JJ
cord-329876-4cgrjnjo	312	6	prefers	prefer	VBZ
cord-329876-4cgrjnjo	312	7	binding	binding	NN
cord-329876-4cgrjnjo	312	8	of	of	IN
cord-329876-4cgrjnjo	312	9	K48-Ub	K48-Ub	NNP
cord-329876-4cgrjnjo	312	10	2	2	CD
cord-329876-4cgrjnjo	312	11	and	and	CC
cord-329876-4cgrjnjo	312	12	ISG15	isg15	NN
cord-329876-4cgrjnjo	312	13	over	over	IN
cord-329876-4cgrjnjo	312	14	mono	mono	NN
cord-329876-4cgrjnjo	312	15	-	-	HYPH
cord-329876-4cgrjnjo	312	16	ubiquitin	ubiquitin	JJ
cord-329876-4cgrjnjo	313	1	(	(	-LRB-
cord-329876-4cgrjnjo	313	2	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	313	3	et	et	NNP
cord-329876-4cgrjnjo	313	4	al	al	NNP
cord-329876-4cgrjnjo	313	5	.	.	.
cord-329876-4cgrjnjo	314	1	,	,	,
cord-329876-4cgrjnjo	314	2	2014	2014	CD
cord-329876-4cgrjnjo	314	3	)	)	-RRB-
cord-329876-4cgrjnjo	314	4	.	.	.
cord-329876-4cgrjnjo	315	1	All	all	DT
cord-329876-4cgrjnjo	315	2	evidence	evidence	NN
cord-329876-4cgrjnjo	315	3	suggests	suggest	VBZ
cord-329876-4cgrjnjo	315	4	that	that	IN
cord-329876-4cgrjnjo	315	5	on	on	IN
cord-329876-4cgrjnjo	315	6	the	the	DT
cord-329876-4cgrjnjo	315	7	PL	pl	NN
cord-329876-4cgrjnjo	315	8	pro	pro	NN
cord-329876-4cgrjnjo	315	9	,	,	,
cord-329876-4cgrjnjo	315	10	at	at	RB
cord-329876-4cgrjnjo	315	11	least	least	RBS
cord-329876-4cgrjnjo	315	12	two	two	CD
cord-329876-4cgrjnjo	315	13	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	315	14	-	-	HYPH
cord-329876-4cgrjnjo	315	15	binding	bind	VBG
cord-329876-4cgrjnjo	315	16	sites	site	NNS
cord-329876-4cgrjnjo	315	17	(	(	-LRB-
cord-329876-4cgrjnjo	315	18	or	or	CC
cord-329876-4cgrjnjo	315	19	a	a	DT
cord-329876-4cgrjnjo	315	20	binding	binding	JJ
cord-329876-4cgrjnjo	315	21	site	site	NN
cord-329876-4cgrjnjo	315	22	for	for	IN
cord-329876-4cgrjnjo	315	23	diubiquitin	diubiquitin	NN
cord-329876-4cgrjnjo	315	24	-	-	HYPH
cord-329876-4cgrjnjo	315	25	like	like	JJ
cord-329876-4cgrjnjo	315	26	molecules	molecule	NNS
cord-329876-4cgrjnjo	315	27	such	such	JJ
cord-329876-4cgrjnjo	315	28	as	as	IN
cord-329876-4cgrjnjo	315	29	ISG15	isg15	NN
cord-329876-4cgrjnjo	315	30	)	)	-RRB-
cord-329876-4cgrjnjo	315	31	exist	exist	VBP
cord-329876-4cgrjnjo	315	32	.	.	.
cord-329876-4cgrjnjo	316	1	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	316	2	et	et	NNP
cord-329876-4cgrjnjo	316	3	al	al	NNP
cord-329876-4cgrjnjo	316	4	.	.	.
cord-329876-4cgrjnjo	317	1	(	(	-LRB-
cord-329876-4cgrjnjo	317	2	2014	2014	CD
cord-329876-4cgrjnjo	317	3	)	)	-RRB-
cord-329876-4cgrjnjo	317	4	proposed	propose	VBN
cord-329876-4cgrjnjo	317	5	hypothetic	hypothetic	JJ
cord-329876-4cgrjnjo	317	6	models	model	NNS
cord-329876-4cgrjnjo	317	7	for	for	IN
cord-329876-4cgrjnjo	317	8	complexes	complex	NNS
cord-329876-4cgrjnjo	317	9	of	of	IN
cord-329876-4cgrjnjo	317	10	SARS	SARS	NNP
cord-329876-4cgrjnjo	317	11	-	-	HYPH
cord-329876-4cgrjnjo	317	12	CoV	CoV	NNP
cord-329876-4cgrjnjo	317	13	PL	pl	NN
cord-329876-4cgrjnjo	317	14	pro	pro	JJ
cord-329876-4cgrjnjo	317	15	with	with	IN
cord-329876-4cgrjnjo	317	16	K48-Ub	K48-Ub	NNP
cord-329876-4cgrjnjo	317	17	2	2	CD
cord-329876-4cgrjnjo	317	18	and	and	CC
cord-329876-4cgrjnjo	317	19	ISG15	isg15	NN
cord-329876-4cgrjnjo	317	20	.	.	.
cord-329876-4cgrjnjo	318	1	These	these	DT
cord-329876-4cgrjnjo	318	2	authors	author	NNS
cord-329876-4cgrjnjo	318	3	identified	identify	VBD
cord-329876-4cgrjnjo	318	4	two	two	CD
cord-329876-4cgrjnjo	318	5	major	major	JJ
cord-329876-4cgrjnjo	318	6	hydrophobic	hydrophobic	JJ
cord-329876-4cgrjnjo	318	7	binding	bind	VBG
cord-329876-4cgrjnjo	318	8	sites	site	NNS
cord-329876-4cgrjnjo	318	9	on	on	IN
cord-329876-4cgrjnjo	318	10	the	the	DT
cord-329876-4cgrjnjo	318	11	PL	pl	NN
cord-329876-4cgrjnjo	318	12	pro	pro	NN
cord-329876-4cgrjnjo	318	13	for	for	IN
cord-329876-4cgrjnjo	318	14	the	the	DT
cord-329876-4cgrjnjo	318	15	first	first	JJ
cord-329876-4cgrjnjo	318	16	Ub	Ub	NNP
cord-329876-4cgrjnjo	318	17	(	(	-LRB-
cord-329876-4cgrjnjo	318	18	Ub1	ub1	NN
cord-329876-4cgrjnjo	318	19	)	)	-RRB-
cord-329876-4cgrjnjo	318	20	and	and	CC
cord-329876-4cgrjnjo	318	21	the	the	DT
cord-329876-4cgrjnjo	318	22	second	second	JJ
cord-329876-4cgrjnjo	318	23	Ub	Ub	NNP
cord-329876-4cgrjnjo	318	24	(	(	-LRB-
cord-329876-4cgrjnjo	318	25	Ub2	ub2	CD
cord-329876-4cgrjnjo	318	26	)	)	-RRB-
cord-329876-4cgrjnjo	318	27	.	.	.
cord-329876-4cgrjnjo	319	1	The	the	DT
cord-329876-4cgrjnjo	319	2	binding	binding	NN
cord-329876-4cgrjnjo	319	3	site	site	NN
cord-329876-4cgrjnjo	319	4	for	for	IN
cord-329876-4cgrjnjo	319	5	Ub1	ub1	NN
cord-329876-4cgrjnjo	319	6	comprises	comprise	VBZ
cord-329876-4cgrjnjo	319	7	Met209	met209	NN
cord-329876-4cgrjnjo	319	8	,	,	,
cord-329876-4cgrjnjo	319	9	Pro248	pro248	ADD
cord-329876-4cgrjnjo	319	10	,	,	,
cord-329876-4cgrjnjo	319	11	and	and	CC
cord-329876-4cgrjnjo	319	12	Pro249	pro249	NN
cord-329876-4cgrjnjo	319	13	.	.	.
cord-329876-4cgrjnjo	320	1	This	this	DT
cord-329876-4cgrjnjo	320	2	hydrophobic	hydrophobic	JJ
cord-329876-4cgrjnjo	320	3	patch	patch	NN
cord-329876-4cgrjnjo	320	4	is	be	VBZ
cord-329876-4cgrjnjo	320	5	conserved	conserve	VBN
cord-329876-4cgrjnjo	320	6	in	in	IN
cord-329876-4cgrjnjo	320	7	MERS	MERS	NNP
cord-329876-4cgrjnjo	320	8	-	-	HYPH
cord-329876-4cgrjnjo	320	9	CoV	CoV	NNP
cord-329876-4cgrjnjo	320	10	PL	pl	NN
cord-329876-4cgrjnjo	320	11	pro	pro	NN
cord-329876-4cgrjnjo	320	12	,	,	,
cord-329876-4cgrjnjo	320	13	although	although	IN
cord-329876-4cgrjnjo	320	14	the	the	DT
cord-329876-4cgrjnjo	320	15	residues	residue	NNS
cord-329876-4cgrjnjo	320	16	are	be	VBP
cord-329876-4cgrjnjo	320	17	not	not	RB
cord-329876-4cgrjnjo	320	18	exactly	exactly	RB
cord-329876-4cgrjnjo	320	19	the	the	DT
cord-329876-4cgrjnjo	320	20	same	same	JJ
cord-329876-4cgrjnjo	320	21	.	.	.
cord-329876-4cgrjnjo	321	1	Met209	met209	NN
cord-329876-4cgrjnjo	321	2	of	of	IN
cord-329876-4cgrjnjo	321	3	SARS	SARS	NNP
cord-329876-4cgrjnjo	321	4	-	-	HYPH
cord-329876-4cgrjnjo	321	5	CoV	CoV	NNP
cord-329876-4cgrjnjo	321	6	PL	pl	NN
cord-329876-4cgrjnjo	321	7	pro	pro	NNP
cord-329876-4cgrjnjo	321	8	is	be	VBZ
cord-329876-4cgrjnjo	321	9	replaced	replace	VBN
cord-329876-4cgrjnjo	321	10	by	by	IN
cord-329876-4cgrjnjo	321	11	Val210	Val210	NNP
cord-329876-4cgrjnjo	321	12	(	(	-LRB-
cord-329876-4cgrjnjo	321	13	region	region	NN
cord-329876-4cgrjnjo	321	14	III	iii	CD
cord-329876-4cgrjnjo	321	15	)	)	-RRB-
cord-329876-4cgrjnjo	321	16	in	in	IN
cord-329876-4cgrjnjo	321	17	MERS-	MERS-	NNP
cord-329876-4cgrjnjo	322	1	CoV.	CoV.	NNP
cord-329876-4cgrjnjo	323	1	Pro248	Pro248	NNP
cord-329876-4cgrjnjo	323	2	is	be	VBZ
cord-329876-4cgrjnjo	323	3	replaced	replace	VBN
cord-329876-4cgrjnjo	323	4	by	by	IN
cord-329876-4cgrjnjo	323	5	Thr249	thr249	ADD
cord-329876-4cgrjnjo	323	6	,	,	,
cord-329876-4cgrjnjo	323	7	whereas	whereas	IN
cord-329876-4cgrjnjo	323	8	Pro249	Pro249	NNP
cord-329876-4cgrjnjo	323	9	is	be	VBZ
cord-329876-4cgrjnjo	323	10	conserved	conserve	VBN
cord-329876-4cgrjnjo	323	11	(	(	-LRB-
cord-329876-4cgrjnjo	324	1	Pro250	Pro250	NNP
cord-329876-4cgrjnjo	324	2	;	;	:
cord-329876-4cgrjnjo	324	3	region	region	NN
cord-329876-4cgrjnjo	324	4	V	v	NN
cord-329876-4cgrjnjo	324	5	)	)	-RRB-
cord-329876-4cgrjnjo	325	1	(	(	-LRB-
cord-329876-4cgrjnjo	325	2	Figure	figure	NN
cord-329876-4cgrjnjo	325	3	5	5	CD
cord-329876-4cgrjnjo	325	4	)	)	-RRB-
cord-329876-4cgrjnjo	325	5	.	.	.
cord-329876-4cgrjnjo	326	1	The	the	DT
cord-329876-4cgrjnjo	326	2	hypothetic	hypothetic	JJ
cord-329876-4cgrjnjo	326	3	second	second	JJ
cord-329876-4cgrjnjo	326	4	binding	binding	NN
cord-329876-4cgrjnjo	326	5	site	site	NN
cord-329876-4cgrjnjo	326	6	for	for	IN
cord-329876-4cgrjnjo	326	7	Ub2	ub2	NN
cord-329876-4cgrjnjo	326	8	(	(	-LRB-
cord-329876-4cgrjnjo	326	9	also	also	RB
cord-329876-4cgrjnjo	326	10	named	name	VBN
cord-329876-4cgrjnjo	326	11	"	"	``
cord-329876-4cgrjnjo	326	12	ridge	ridge	NN
cord-329876-4cgrjnjo	326	13	"	"	''
cord-329876-4cgrjnjo	326	14	region	region	NN
cord-329876-4cgrjnjo	326	15	,	,	,
cord-329876-4cgrjnjo	326	16	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	326	17	et	et	NNP
cord-329876-4cgrjnjo	326	18	al	al	NNP
cord-329876-4cgrjnjo	326	19	.	.	NNP
cord-329876-4cgrjnjo	326	20	,	,	,
cord-329876-4cgrjnjo	326	21	2014	2014	CD
cord-329876-4cgrjnjo	326	22	)	)	-RRB-
cord-329876-4cgrjnjo	326	23	is	be	VBZ
cord-329876-4cgrjnjo	326	24	located	locate	VBN
cord-329876-4cgrjnjo	326	25	to	to	IN
cord-329876-4cgrjnjo	326	26	the	the	DT
cord-329876-4cgrjnjo	326	27	first	first	JJ
cord-329876-4cgrjnjo	326	28	α	α	NNP
cord-329876-4cgrjnjo	326	29	helix	helix	NN
cord-329876-4cgrjnjo	326	30	(	(	-LRB-
cord-329876-4cgrjnjo	326	31	α2	α2	NNP
cord-329876-4cgrjnjo	326	32	)	)	-RRB-
cord-329876-4cgrjnjo	326	33	in	in	IN
cord-329876-4cgrjnjo	326	34	the	the	DT
cord-329876-4cgrjnjo	326	35	thumb	thumb	NN
cord-329876-4cgrjnjo	326	36	domain	domain	NN
cord-329876-4cgrjnjo	326	37	,	,	,
cord-329876-4cgrjnjo	326	38	including	include	VBG
cord-329876-4cgrjnjo	326	39	residues	residue	NNS
cord-329876-4cgrjnjo	326	40	Phe70	Phe70	NNP
cord-329876-4cgrjnjo	326	41	,	,	,
cord-329876-4cgrjnjo	326	42	His74	His74	NNP
cord-329876-4cgrjnjo	326	43	,	,	,
cord-329876-4cgrjnjo	326	44	and	and	CC
cord-329876-4cgrjnjo	326	45	Leu76	Leu76	NNP
cord-329876-4cgrjnjo	326	46	of	of	IN
cord-329876-4cgrjnjo	326	47	SARS	SARS	NNP
cord-329876-4cgrjnjo	326	48	-	-	HYPH
cord-329876-4cgrjnjo	326	49	CoV	CoV	NNP
cord-329876-4cgrjnjo	326	50	PL	pl	NN
cord-329876-4cgrjnjo	326	51	pro	pro	NNP
cord-329876-4cgrjnjo	326	52	.	.	.
cord-329876-4cgrjnjo	327	1	According	accord	VBG
cord-329876-4cgrjnjo	327	2	to	to	IN
cord-329876-4cgrjnjo	327	3	a	a	DT
cord-329876-4cgrjnjo	327	4	structural	structural	JJ
cord-329876-4cgrjnjo	327	5	alignment	alignment	NN
cord-329876-4cgrjnjo	327	6	of	of	IN
cord-329876-4cgrjnjo	327	7	the	the	DT
cord-329876-4cgrjnjo	327	8	SARS	SARS	NNP
cord-329876-4cgrjnjo	327	9	-	-	HYPH
cord-329876-4cgrjnjo	327	10	CoV	CoV	NNP
cord-329876-4cgrjnjo	327	11	and	and	CC
cord-329876-4cgrjnjo	327	12	MERS	MERS	NNP
cord-329876-4cgrjnjo	327	13	-	-	HYPH
cord-329876-4cgrjnjo	327	14	CoV	CoV	NNP
cord-329876-4cgrjnjo	327	15	PL	pl	NN
cord-329876-4cgrjnjo	327	16	pro	pro	NNP
cord-329876-4cgrjnjo	327	17	s	s	NNP
cord-329876-4cgrjnjo	327	18	,	,	,
cord-329876-4cgrjnjo	327	19	Phe70	Phe70	NNP
cord-329876-4cgrjnjo	327	20	,	,	,
cord-329876-4cgrjnjo	327	21	His74	His74	NNP
cord-329876-4cgrjnjo	327	22	,	,	,
cord-329876-4cgrjnjo	327	23	and	and	CC
cord-329876-4cgrjnjo	327	24	Leu76	Leu76	NNP
cord-329876-4cgrjnjo	327	25	are	be	VBP
cord-329876-4cgrjnjo	327	26	changed	change	VBN
cord-329876-4cgrjnjo	327	27	to	to	IN
cord-329876-4cgrjnjo	327	28	Lys69	Lys69	NNP
cord-329876-4cgrjnjo	327	29	,	,	,
cord-329876-4cgrjnjo	327	30	Gly73	Gly73	NNP
cord-329876-4cgrjnjo	327	31	,	,	,
cord-329876-4cgrjnjo	327	32	and	and	CC
cord-329876-4cgrjnjo	327	33	Val75	Val75	NNP
cord-329876-4cgrjnjo	327	34	,	,	,
cord-329876-4cgrjnjo	327	35	respectively	respectively	RB
cord-329876-4cgrjnjo	327	36	(	(	-LRB-
cord-329876-4cgrjnjo	327	37	Figure	figure	NN
cord-329876-4cgrjnjo	327	38	5	5	CD
cord-329876-4cgrjnjo	327	39	)	)	-RRB-
cord-329876-4cgrjnjo	327	40	.	.	.
cord-329876-4cgrjnjo	328	1	In	in	IN
cord-329876-4cgrjnjo	328	2	SARS	SARS	NNP
cord-329876-4cgrjnjo	328	3	-	-	HYPH
cord-329876-4cgrjnjo	328	4	CoV	CoV	NNP
cord-329876-4cgrjnjo	328	5	PL	PL	NNP
cord-329876-4cgrjnjo	328	6	pro	pro	NNP
cord-329876-4cgrjnjo	328	7	,	,	,
cord-329876-4cgrjnjo	328	8	the	the	DT
cord-329876-4cgrjnjo	328	9	F70S	F70S	NNPS
cord-329876-4cgrjnjo	328	10	and	and	CC
cord-329876-4cgrjnjo	328	11	F70A	F70A	NNP
cord-329876-4cgrjnjo	328	12	replacements	replacement	NNS
cord-329876-4cgrjnjo	328	13	lost	lose	VBD
cord-329876-4cgrjnjo	328	14	the	the	DT
cord-329876-4cgrjnjo	328	15	affinity	affinity	NN
cord-329876-4cgrjnjo	328	16	to	to	IN
cord-329876-4cgrjnjo	328	17	K48-Ub	K48-Ub	NNP
cord-329876-4cgrjnjo	328	18	2	2	CD
cord-329876-4cgrjnjo	329	1	and	and	CC
cord-329876-4cgrjnjo	329	2	ISG15	isg15	NN
cord-329876-4cgrjnjo	330	1	in	in	IN
cord-329876-4cgrjnjo	330	2	vitro	vitro	FW
cord-329876-4cgrjnjo	330	3	(	(	-LRB-
cord-329876-4cgrjnjo	330	4	Ratia	Ratia	NNP
cord-329876-4cgrjnjo	330	5	et	et	NNP
cord-329876-4cgrjnjo	330	6	al	al	NNP
cord-329876-4cgrjnjo	330	7	.	.	NNP
cord-329876-4cgrjnjo	330	8	,	,	,
cord-329876-4cgrjnjo	330	9	2014	2014	CD
cord-329876-4cgrjnjo	330	10	)	)	-RRB-
cord-329876-4cgrjnjo	331	1	;	;	:
cord-329876-4cgrjnjo	331	2	therefore	therefore	RB
cord-329876-4cgrjnjo	331	3	,	,	,
cord-329876-4cgrjnjo	331	4	the	the	DT
cord-329876-4cgrjnjo	331	5	presence	presence	NN
cord-329876-4cgrjnjo	331	6	of	of	IN
cord-329876-4cgrjnjo	331	7	Lys69	Lys69	NNP
cord-329876-4cgrjnjo	331	8	in	in	IN
cord-329876-4cgrjnjo	331	9	MERS	MERS	NNP
cord-329876-4cgrjnjo	331	10	-	-	HYPH
cord-329876-4cgrjnjo	331	11	CoV	CoV	NNP
cord-329876-4cgrjnjo	331	12	PL	pl	NN
cord-329876-4cgrjnjo	331	13	pro	pro	JJ
cord-329876-4cgrjnjo	331	14	instead	instead	RB
cord-329876-4cgrjnjo	331	15	of	of	IN
cord-329876-4cgrjnjo	331	16	Phe70	Phe70	NNP
cord-329876-4cgrjnjo	331	17	strongly	strongly	RB
cord-329876-4cgrjnjo	331	18	suggests	suggest	VBZ
cord-329876-4cgrjnjo	331	19	that	that	IN
cord-329876-4cgrjnjo	331	20	this	this	DT
cord-329876-4cgrjnjo	331	21	enzyme	enzyme	NN
cord-329876-4cgrjnjo	331	22	should	should	MD
cord-329876-4cgrjnjo	331	23	bind	bind	VB
cord-329876-4cgrjnjo	331	24	Ub2	ub2	CD
cord-329876-4cgrjnjo	331	25	in	in	IN
cord-329876-4cgrjnjo	331	26	a	a	DT
cord-329876-4cgrjnjo	331	27	different	different	JJ
cord-329876-4cgrjnjo	331	28	way	way	NN
cord-329876-4cgrjnjo	331	29	.	.	.
cord-329876-4cgrjnjo	332	1	Bailey	Bailey	NNP
cord-329876-4cgrjnjo	332	2	-	-	HYPH
cord-329876-4cgrjnjo	332	3	Elkin	Elkin	NNP
cord-329876-4cgrjnjo	332	4	et	et	NNP
cord-329876-4cgrjnjo	332	5	al	al	NNP
cord-329876-4cgrjnjo	332	6	.	.	.
cord-329876-4cgrjnjo	333	1	(	(	-LRB-
cord-329876-4cgrjnjo	333	2	2014	2014	CD
cord-329876-4cgrjnjo	333	3	)	)	-RRB-
cord-329876-4cgrjnjo	333	4	predicted	predict	VBD
cord-329876-4cgrjnjo	333	5	Asn1673	Asn1673	NNP
cord-329876-4cgrjnjo	333	6	and	and	CC
cord-329876-4cgrjnjo	333	7	Val1674	Val1674	NNP
cord-329876-4cgrjnjo	333	8	of	of	IN
cord-329876-4cgrjnjo	333	9	the	the	DT
cord-329876-4cgrjnjo	333	10	fingers	finger	NNS
cord-329876-4cgrjnjo	333	11	subdomain	subdomain	NN
cord-329876-4cgrjnjo	333	12	(	(	-LRB-
cord-329876-4cgrjnjo	333	13	corresponding	correspond	VBG
cord-329876-4cgrjnjo	333	14	to	to	IN
cord-329876-4cgrjnjo	333	15	Asn192	asn192	CD
cord-329876-4cgrjnjo	333	16	and	and	CC
cord-329876-4cgrjnjo	333	17	Val193	val193	CD
cord-329876-4cgrjnjo	333	18	in	in	IN
cord-329876-4cgrjnjo	333	19	our	-PRON-	PRP$
cord-329876-4cgrjnjo	333	20	PL	pl	NN
cord-329876-4cgrjnjo	333	21	pro	pro	FW
cord-329876-4cgrjnjo	333	22	)	)	-RRB-
cord-329876-4cgrjnjo	333	23	as	as	IN
cord-329876-4cgrjnjo	333	24	the	the	DT
cord-329876-4cgrjnjo	333	25	distal	distal	JJ
cord-329876-4cgrjnjo	333	26	Ub	Ub	NNP
cord-329876-4cgrjnjo	333	27	site	site	NN
cord-329876-4cgrjnjo	333	28	of	of	IN
cord-329876-4cgrjnjo	333	29	K63	K63	NNP
cord-329876-4cgrjnjo	333	30	di	di	NNP
cord-329876-4cgrjnjo	333	31	-	-	HYPH
cord-329876-4cgrjnjo	333	32	Ub	Ub	NNP
cord-329876-4cgrjnjo	333	33	,	,	,
cord-329876-4cgrjnjo	333	34	but	but	CC
cord-329876-4cgrjnjo	333	35	they	-PRON-	PRP
cord-329876-4cgrjnjo	333	36	found	find	VBD
cord-329876-4cgrjnjo	333	37	that	that	IN
cord-329876-4cgrjnjo	333	38	their	-PRON-	PRP$
cord-329876-4cgrjnjo	333	39	DUB	dub	NN
cord-329876-4cgrjnjo	333	40	activity	activity	NN
cord-329876-4cgrjnjo	333	41	data	datum	NNS
cord-329876-4cgrjnjo	333	42	do	do	VBP
cord-329876-4cgrjnjo	333	43	not	not	RB
cord-329876-4cgrjnjo	333	44	support	support	VB
cord-329876-4cgrjnjo	333	45	their	-PRON-	PRP$
cord-329876-4cgrjnjo	333	46	prediction	prediction	NN
cord-329876-4cgrjnjo	333	47	for	for	IN
cord-329876-4cgrjnjo	333	48	the	the	DT
cord-329876-4cgrjnjo	333	49	Ub2	Ub2	NNP
cord-329876-4cgrjnjo	333	50	binding	binding	NN
cord-329876-4cgrjnjo	333	51	site	site	NN
cord-329876-4cgrjnjo	333	52	.	.	.
cord-329876-4cgrjnjo	334	1	The	the	DT
cord-329876-4cgrjnjo	334	2	structure	structure	NN
cord-329876-4cgrjnjo	334	3	of	of	IN
cord-329876-4cgrjnjo	334	4	the	the	DT
cord-329876-4cgrjnjo	334	5	MERS	MERS	NNP
cord-329876-4cgrjnjo	334	6	-	-	HYPH
cord-329876-4cgrjnjo	334	7	CoV	cov	NN
cord-329876-4cgrjnjo	334	8	PL	pl	NN
cord-329876-4cgrjnjo	334	9	pro	pro	JJ
cord-329876-4cgrjnjo	334	10	-Ub	-ub	NN
cord-329876-4cgrjnjo	334	11	complex	complex	NN
cord-329876-4cgrjnjo	334	12	reported	report	VBN
cord-329876-4cgrjnjo	334	13	here	here	RB
cord-329876-4cgrjnjo	334	14	reveals	reveal	VBZ
cord-329876-4cgrjnjo	334	15	the	the	DT
cord-329876-4cgrjnjo	334	16	exact	exact	JJ
cord-329876-4cgrjnjo	334	17	Ub1	ub1	NN
cord-329876-4cgrjnjo	334	18	binding	bind	VBG
cord-329876-4cgrjnjo	334	19	site	site	NN
cord-329876-4cgrjnjo	334	20	on	on	IN
cord-329876-4cgrjnjo	334	21	the	the	DT
cord-329876-4cgrjnjo	334	22	PL	pl	NN
cord-329876-4cgrjnjo	334	23	pro	pro	NN
cord-329876-4cgrjnjo	334	24	,	,	,
cord-329876-4cgrjnjo	334	25	but	but	CC
cord-329876-4cgrjnjo	334	26	the	the	DT
cord-329876-4cgrjnjo	334	27	Ub2	Ub2	NNP
cord-329876-4cgrjnjo	334	28	binding	binding	NN
cord-329876-4cgrjnjo	334	29	site	site	NN
cord-329876-4cgrjnjo	334	30	should	should	MD
cord-329876-4cgrjnjo	334	31	be	be	VB
cord-329876-4cgrjnjo	334	32	identified	identify	VBN
cord-329876-4cgrjnjo	334	33	by	by	IN
cord-329876-4cgrjnjo	334	34	crystallizing	crystallize	VBG
cord-329876-4cgrjnjo	334	35	the	the	DT
cord-329876-4cgrjnjo	334	36	PL	pl	NN
cord-329876-4cgrjnjo	334	37	pro	pro	NN
cord-329876-4cgrjnjo	334	38	in	in	IN
cord-329876-4cgrjnjo	334	39	complex	complex	NN
cord-329876-4cgrjnjo	334	40	with	with	IN
cord-329876-4cgrjnjo	334	41	poly	poly	NN
cord-329876-4cgrjnjo	334	42	-	-	:
cord-329876-4cgrjnjo	334	43	or	or	CC
cord-329876-4cgrjnjo	334	44	di	di	NN
cord-329876-4cgrjnjo	334	45	-	-	HYPH
cord-329876-4cgrjnjo	334	46	ubiquitin	ubiquitin	JJ
cord-329876-4cgrjnjo	334	47	.	.	.
cord-329876-4cgrjnjo	335	1	In	in	IN
cord-329876-4cgrjnjo	335	2	summary	summary	NN
cord-329876-4cgrjnjo	335	3	,	,	,
cord-329876-4cgrjnjo	335	4	the	the	DT
cord-329876-4cgrjnjo	335	5	crystal	crystal	NN
cord-329876-4cgrjnjo	335	6	structure	structure	NN
cord-329876-4cgrjnjo	335	7	of	of	IN
cord-329876-4cgrjnjo	335	8	the	the	DT
cord-329876-4cgrjnjo	335	9	MERS	MERS	NNP
cord-329876-4cgrjnjo	335	10	-	-	HYPH
cord-329876-4cgrjnjo	335	11	CoV	cov	NN
cord-329876-4cgrjnjo	335	12	PL	pl	NN
cord-329876-4cgrjnjo	335	13	pro	pro	JJ
cord-329876-4cgrjnjo	335	14	-Ub	-ub	NN
cord-329876-4cgrjnjo	335	15	complex	complex	JJ
cord-329876-4cgrjnjo	335	16	provides	provide	VBZ
cord-329876-4cgrjnjo	335	17	valuable	valuable	JJ
cord-329876-4cgrjnjo	335	18	information	information	NN
cord-329876-4cgrjnjo	335	19	that	that	WDT
cord-329876-4cgrjnjo	335	20	helps	help	VBZ
cord-329876-4cgrjnjo	335	21	understand	understand	VB
cord-329876-4cgrjnjo	335	22	the	the	DT
cord-329876-4cgrjnjo	335	23	multiple	multiple	JJ
cord-329876-4cgrjnjo	335	24	functions	function	NNS
cord-329876-4cgrjnjo	335	25	of	of	IN
cord-329876-4cgrjnjo	335	26	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	335	27	papain	papain	NN
cord-329876-4cgrjnjo	335	28	-	-	HYPH
cord-329876-4cgrjnjo	335	29	like	like	JJ
cord-329876-4cgrjnjo	335	30	proteases	protease	NNS
cord-329876-4cgrjnjo	335	31	.	.	.
cord-329876-4cgrjnjo	336	1	Mutational	Mutational	NNP
cord-329876-4cgrjnjo	336	2	studies	study	NNS
cord-329876-4cgrjnjo	336	3	additionally	additionally	RB
cord-329876-4cgrjnjo	336	4	highlight	highlight	VBP
cord-329876-4cgrjnjo	336	5	features	feature	NNS
cord-329876-4cgrjnjo	336	6	of	of	IN
cord-329876-4cgrjnjo	336	7	the	the	DT
cord-329876-4cgrjnjo	336	8	MERS	MERS	NNP
cord-329876-4cgrjnjo	336	9	-	-	HYPH
cord-329876-4cgrjnjo	336	10	CoV	CoV	NNP
cord-329876-4cgrjnjo	336	11	PL	pl	NN
cord-329876-4cgrjnjo	336	12	pro	pro	NNP
cord-329876-4cgrjnjo	336	13	.	.	.
cord-329876-4cgrjnjo	337	1	The	the	DT
cord-329876-4cgrjnjo	337	2	different	different	JJ
cord-329876-4cgrjnjo	337	3	substrate	substrate	NN
cord-329876-4cgrjnjo	337	4	-	-	HYPH
cord-329876-4cgrjnjo	337	5	binding	bind	VBG
cord-329876-4cgrjnjo	337	6	patterns	pattern	NNS
cord-329876-4cgrjnjo	337	7	should	should	MD
cord-329876-4cgrjnjo	337	8	be	be	VB
cord-329876-4cgrjnjo	337	9	kept	keep	VBN
cord-329876-4cgrjnjo	337	10	in	in	IN
cord-329876-4cgrjnjo	337	11	mind	mind	NN
cord-329876-4cgrjnjo	337	12	when	when	WRB
cord-329876-4cgrjnjo	337	13	designing	design	VBG
cord-329876-4cgrjnjo	337	14	inhibitors	inhibitor	NNS
cord-329876-4cgrjnjo	337	15	for	for	IN
cord-329876-4cgrjnjo	337	16	PL	pl	NN
cord-329876-4cgrjnjo	337	17	pro	pro	NNP
cord-329876-4cgrjnjo	337	18	s	s	NN
cord-329876-4cgrjnjo	337	19	of	of	IN
cord-329876-4cgrjnjo	337	20	CoVs	CoVs	NNP
cord-329876-4cgrjnjo	337	21	,	,	,
cord-329876-4cgrjnjo	337	22	even	even	RB
cord-329876-4cgrjnjo	337	23	though	though	IN
cord-329876-4cgrjnjo	337	24	the	the	DT
cord-329876-4cgrjnjo	337	25	overall	overall	JJ
cord-329876-4cgrjnjo	337	26	structures	structure	NNS
cord-329876-4cgrjnjo	337	27	of	of	IN
cord-329876-4cgrjnjo	337	28	these	these	DT
cord-329876-4cgrjnjo	337	29	enzymes	enzyme	NNS
cord-329876-4cgrjnjo	337	30	are	be	VBP
cord-329876-4cgrjnjo	337	31	conserved	conserve	VBN
cord-329876-4cgrjnjo	337	32	.	.	.
cord-329876-4cgrjnjo	338	1	Furthermore	furthermore	RB
cord-329876-4cgrjnjo	338	2	,	,	,
cord-329876-4cgrjnjo	338	3	it	-PRON-	PRP
cord-329876-4cgrjnjo	338	4	would	would	MD
cord-329876-4cgrjnjo	338	5	be	be	VB
cord-329876-4cgrjnjo	338	6	helpful	helpful	JJ
cord-329876-4cgrjnjo	338	7	to	to	TO
cord-329876-4cgrjnjo	338	8	obtain	obtain	VB
cord-329876-4cgrjnjo	338	9	the	the	DT
cord-329876-4cgrjnjo	338	10	structure	structure	NN
cord-329876-4cgrjnjo	338	11	of	of	IN
cord-329876-4cgrjnjo	338	12	PL	PL	NNP
cord-329876-4cgrjnjo	338	13	pro	pro	JJ
cord-329876-4cgrjnjo	338	14	in	in	IN
cord-329876-4cgrjnjo	338	15	complex	complex	NN
cord-329876-4cgrjnjo	338	16	with	with	IN
cord-329876-4cgrjnjo	338	17	di	di	NNP
cord-329876-4cgrjnjo	338	18	-	-	HYPH
cord-329876-4cgrjnjo	338	19	Ub	Ub	NNP
cord-329876-4cgrjnjo	338	20	or	or	CC
cord-329876-4cgrjnjo	338	21	ISG15	isg15	NN
cord-329876-4cgrjnjo	338	22	in	in	IN
cord-329876-4cgrjnjo	338	23	the	the	DT
cord-329876-4cgrjnjo	338	24	future	future	NN
cord-329876-4cgrjnjo	338	25	.	.	.
cord-329876-4cgrjnjo	339	1	ing	ing	DT
cord-329876-4cgrjnjo	339	2	sites	site	NNS
cord-329876-4cgrjnjo	339	3	are	be	VBP
cord-329876-4cgrjnjo	339	4	depicted	depict	VBN
cord-329876-4cgrjnjo	339	5	as	as	IN
cord-329876-4cgrjnjo	339	6	purple	purple	JJ
cord-329876-4cgrjnjo	339	7	dots	dot	NNS
cord-329876-4cgrjnjo	339	8	.	.	.
cord-329876-4cgrjnjo	340	1	The	the	DT
cord-329876-4cgrjnjo	340	2	N	N	NNP
cord-329876-4cgrjnjo	340	3	and	and	CC
cord-329876-4cgrjnjo	340	4	C	C	NNP
cord-329876-4cgrjnjo	340	5	termini	terminus	NNS
cord-329876-4cgrjnjo	340	6	of	of	IN
cord-329876-4cgrjnjo	340	7	PL	PL	NNP
cord-329876-4cgrjnjo	340	8	pro	pro	NNP
cord-329876-4cgrjnjo	340	9	are	be	VBP
cord-329876-4cgrjnjo	340	10	marked	mark	VBN
cord-329876-4cgrjnjo	340	11	by	by	IN
cord-329876-4cgrjnjo	340	12	underlined	underlined	JJ
cord-329876-4cgrjnjo	340	13	letters	letter	NNS
cord-329876-4cgrjnjo	340	14	.	.	.
cord-329876-4cgrjnjo	341	1	All	all	DT
cord-329876-4cgrjnjo	341	2	residues	residue	NNS
cord-329876-4cgrjnjo	341	3	related	relate	VBN
cord-329876-4cgrjnjo	341	4	to	to	IN
cord-329876-4cgrjnjo	341	5	the	the	DT
cord-329876-4cgrjnjo	341	6	two	two	CD
cord-329876-4cgrjnjo	341	7	Ub	Ub	NNP
cord-329876-4cgrjnjo	341	8	binding	binding	NN
cord-329876-4cgrjnjo	341	9	sites	site	NNS
cord-329876-4cgrjnjo	341	10	are	be	VBP
cord-329876-4cgrjnjo	341	11	labeled	label	VBN
cord-329876-4cgrjnjo	341	12	.	.	.
cord-329876-4cgrjnjo	342	1	The	the	DT
cord-329876-4cgrjnjo	342	2	catalytic	catalytic	JJ
cord-329876-4cgrjnjo	342	3	triad	triad	NN
cord-329876-4cgrjnjo	342	4	Cys111-His278-Asp293	Cys111-His278-Asp293	NNP
cord-329876-4cgrjnjo	342	5	is	be	VBZ
cord-329876-4cgrjnjo	342	6	indicated	indicate	VBN
cord-329876-4cgrjnjo	342	7	by	by	IN
cord-329876-4cgrjnjo	342	8	yellow	yellow	JJ
cord-329876-4cgrjnjo	342	9	,	,	,
cord-329876-4cgrjnjo	342	10	blue	blue	JJ
cord-329876-4cgrjnjo	342	11	,	,	,
cord-329876-4cgrjnjo	342	12	and	and	CC
cord-329876-4cgrjnjo	342	13	red	red	JJ
cord-329876-4cgrjnjo	342	14	spheres	sphere	NNS
cord-329876-4cgrjnjo	342	15	.	.	.
cord-329876-4cgrjnjo	343	1	KSA	KSA	NNP
cord-329876-4cgrjnjo	343	2	MERS	MERS	NNP
cord-329876-4cgrjnjo	343	3	-	-	HYPH
cord-329876-4cgrjnjo	343	4	CoV	CoV	NNP
cord-329876-4cgrjnjo	343	5	Investigation	Investigation	NNP
cord-329876-4cgrjnjo	343	6	Team	Team	NNP
cord-329876-4cgrjnjo	343	7	.	.	.
cord-329876-4cgrjnjo	344	1	2013	2013	CD
cord-329876-4cgrjnjo	344	2	.	.	.
cord-329876-4cgrjnjo	345	1	Hospital	hospital	NN
cord-329876-4cgrjnjo	345	2	outbreak	outbreak	NN
cord-329876-4cgrjnjo	345	3	of	of	IN
cord-329876-4cgrjnjo	345	4	Middle	Middle	NNP
cord-329876-4cgrjnjo	345	5	East	East	NNP
cord-329876-4cgrjnjo	345	6	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	345	7	syndrome	syndrome	NN
cord-329876-4cgrjnjo	345	8	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	345	9	Xray	Xray	NNP
cord-329876-4cgrjnjo	345	10	structural	structural	JJ
cord-329876-4cgrjnjo	345	11	and	and	CC
cord-329876-4cgrjnjo	345	12	biological	biological	JJ
cord-329876-4cgrjnjo	345	13	evaluation	evaluation	NN
cord-329876-4cgrjnjo	345	14	of	of	IN
cord-329876-4cgrjnjo	345	15	a	a	DT
cord-329876-4cgrjnjo	345	16	series	series	NN
cord-329876-4cgrjnjo	345	17	of	of	IN
cord-329876-4cgrjnjo	345	18	potent	potent	JJ
cord-329876-4cgrjnjo	345	19	and	and	CC
cord-329876-4cgrjnjo	345	20	highly	highly	RB
cord-329876-4cgrjnjo	345	21	selective	selective	JJ
cord-329876-4cgrjnjo	345	22	inhibitors	inhibitor	NNS
cord-329876-4cgrjnjo	345	23	of	of	IN
cord-329876-4cgrjnjo	345	24	human	human	JJ
cord-329876-4cgrjnjo	345	25	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	345	26	papain	papain	NN
cord-329876-4cgrjnjo	345	27	-	-	HYPH
cord-329876-4cgrjnjo	345	28	like	like	JJ
cord-329876-4cgrjnjo	345	29	proteases	protease	NNS
cord-329876-4cgrjnjo	345	30	Catalytic	catalytic	JJ
cord-329876-4cgrjnjo	345	31	function	function	NN
cord-329876-4cgrjnjo	345	32	and	and	CC
cord-329876-4cgrjnjo	345	33	substrate	substrate	NN
cord-329876-4cgrjnjo	345	34	specificity	specificity	NN
cord-329876-4cgrjnjo	345	35	of	of	IN
cord-329876-4cgrjnjo	345	36	the	the	DT
cord-329876-4cgrjnjo	345	37	PLpro	PLpro	NNP
cord-329876-4cgrjnjo	345	38	domain	domain	NN
cord-329876-4cgrjnjo	345	39	of	of	IN
cord-329876-4cgrjnjo	345	40	nsp3	nsp3	NNS
cord-329876-4cgrjnjo	345	41	from	from	IN
cord-329876-4cgrjnjo	345	42	the	the	DT
cord-329876-4cgrjnjo	345	43	Middle	Middle	NNP
cord-329876-4cgrjnjo	345	44	East	East	NNP
cord-329876-4cgrjnjo	345	45	Respiratory	Respiratory	NNP
cord-329876-4cgrjnjo	345	46	Syndrome	Syndrome	NNP
cord-329876-4cgrjnjo	345	47	Coronavirus	Coronavirus	NNP
cord-329876-4cgrjnjo	345	48	(	(	-LRB-
cord-329876-4cgrjnjo	345	49	MERS	MERS	NNP
cord-329876-4cgrjnjo	345	50	-	-	HYPH
cord-329876-4cgrjnjo	345	51	CoV	CoV	NNP
cord-329876-4cgrjnjo	345	52	)	)	-RRB-
cord-329876-4cgrjnjo	346	1	Crystal	crystal	NN
cord-329876-4cgrjnjo	346	2	structure	structure	NN
cord-329876-4cgrjnjo	346	3	of	of	IN
cord-329876-4cgrjnjo	346	4	the	the	DT
cord-329876-4cgrjnjo	346	5	Middle	Middle	NNP
cord-329876-4cgrjnjo	346	6	East	East	NNP
cord-329876-4cgrjnjo	346	7	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	346	8	syndrome	syndrome	NN
cord-329876-4cgrjnjo	346	9	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	346	10	(	(	-LRB-
cord-329876-4cgrjnjo	346	11	MERS	MERS	NNP
cord-329876-4cgrjnjo	346	12	-	-	HYPH
cord-329876-4cgrjnjo	346	13	CoV	CoV	NNP
cord-329876-4cgrjnjo	346	14	)	)	-RRB-
cord-329876-4cgrjnjo	347	1	papain	papain	NN
cord-329876-4cgrjnjo	347	2	-	-	HYPH
cord-329876-4cgrjnjo	347	3	like	like	JJ
cord-329876-4cgrjnjo	347	4	protease	protease	NN
cord-329876-4cgrjnjo	347	5	bound	bind	VBN
cord-329876-4cgrjnjo	347	6	to	to	IN
cord-329876-4cgrjnjo	347	7	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	347	8	facilitates	facilitate	VBZ
cord-329876-4cgrjnjo	347	9	targeted	target	VBN
cord-329876-4cgrjnjo	347	10	disruption	disruption	NN
cord-329876-4cgrjnjo	347	11	of	of	IN
cord-329876-4cgrjnjo	347	12	deubiquitinating	deubiquitinate	VBG
cord-329876-4cgrjnjo	347	13	activity	activity	NN
cord-329876-4cgrjnjo	347	14	to	to	TO
cord-329876-4cgrjnjo	347	15	demonstrate	demonstrate	VB
cord-329876-4cgrjnjo	347	16	its	-PRON-	PRP$
cord-329876-4cgrjnjo	347	17	role	role	NN
cord-329876-4cgrjnjo	347	18	in	in	IN
cord-329876-4cgrjnjo	347	19	innate	innate	JJ
cord-329876-4cgrjnjo	347	20	immune	immune	JJ
cord-329876-4cgrjnjo	347	21	suppression	suppression	NN
cord-329876-4cgrjnjo	348	1	The	the	DT
cord-329876-4cgrjnjo	348	2	papain	papain	NN
cord-329876-4cgrjnjo	348	3	-	-	HYPH
cord-329876-4cgrjnjo	348	4	like	like	JJ
cord-329876-4cgrjnjo	348	5	protease	protease	NN
cord-329876-4cgrjnjo	348	6	of	of	IN
cord-329876-4cgrjnjo	348	7	severe	severe	JJ
cord-329876-4cgrjnjo	348	8	acute	acute	JJ
cord-329876-4cgrjnjo	348	9	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	348	10	syndrome	syndrome	NN
cord-329876-4cgrjnjo	348	11	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	348	12	has	have	VBZ
cord-329876-4cgrjnjo	348	13	deubiquitinating	deubiquitinate	VBG
cord-329876-4cgrjnjo	348	14	activity	activity	NN
cord-329876-4cgrjnjo	348	15	SARS	SARS	NNP
cord-329876-4cgrjnjo	348	16	hCoV	hcov	ADD
cord-329876-4cgrjnjo	349	1	papain	papain	NN
cord-329876-4cgrjnjo	349	2	-	-	HYPH
cord-329876-4cgrjnjo	349	3	like	like	JJ
cord-329876-4cgrjnjo	349	4	protease	protease	NN
cord-329876-4cgrjnjo	349	5	is	be	VBZ
cord-329876-4cgrjnjo	349	6	a	a	DT
cord-329876-4cgrjnjo	349	7	unique	unique	JJ
cord-329876-4cgrjnjo	349	8	Lys	Lys	NNP
cord-329876-4cgrjnjo	349	9	48	48	CD
cord-329876-4cgrjnjo	349	10	linkage	linkage	NN
cord-329876-4cgrjnjo	349	11	-	-	HYPH
cord-329876-4cgrjnjo	349	12	specific	specific	JJ
cord-329876-4cgrjnjo	349	13	di	di	FW
cord-329876-4cgrjnjo	349	14	-	-	HYPH
cord-329876-4cgrjnjo	349	15	distributive	distributive	JJ
cord-329876-4cgrjnjo	349	16	deubiquitinating	deubiquitinating	NN
cord-329876-4cgrjnjo	349	17	enzyme	enzyme	NN
cord-329876-4cgrjnjo	349	18	South	south	JJ
cord-329876-4cgrjnjo	349	19	Korean	korean	JJ
cord-329876-4cgrjnjo	349	20	MERS	MERS	NNP
cord-329876-4cgrjnjo	349	21	outbreak	outbreak	NN
cord-329876-4cgrjnjo	349	22	spotlights	spotlight	NNS
cord-329876-4cgrjnjo	349	23	lack	lack	NN
cord-329876-4cgrjnjo	349	24	of	of	IN
cord-329876-4cgrjnjo	349	25	research	research	NN
cord-329876-4cgrjnjo	350	1	The	the	DT
cord-329876-4cgrjnjo	350	2	SARS	SARS	NNP
cord-329876-4cgrjnjo	350	3	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	350	4	nucleocapsid	nucleocapsid	NN
cord-329876-4cgrjnjo	350	5	protein	protein	NN
cord-329876-4cgrjnjo	350	6	-	-	HYPH
cord-329876-4cgrjnjo	350	7	forms	form	NNS
cord-329876-4cgrjnjo	350	8	and	and	CC
cord-329876-4cgrjnjo	350	9	functions	function	VBZ
cord-329876-4cgrjnjo	350	10	MolProbity	MolProbity	NNP
cord-329876-4cgrjnjo	350	11	:	:	:
cord-329876-4cgrjnjo	351	1	all	all	DT
cord-329876-4cgrjnjo	351	2	-	-	HYPH
cord-329876-4cgrjnjo	351	3	atom	atom	NN
cord-329876-4cgrjnjo	351	4	structure	structure	NN
cord-329876-4cgrjnjo	351	5	validation	validation	NN
cord-329876-4cgrjnjo	351	6	for	for	IN
cord-329876-4cgrjnjo	351	7	macromolecular	macromolecular	JJ
cord-329876-4cgrjnjo	351	8	crystallography	crystallography	NN
cord-329876-4cgrjnjo	352	1	Functional	functional	JJ
cord-329876-4cgrjnjo	352	2	screen	screen	NN
cord-329876-4cgrjnjo	352	3	reveals	reveal	VBZ
cord-329876-4cgrjnjo	352	4	SARS	SARS	NNP
cord-329876-4cgrjnjo	352	5	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	352	6	nonstructural	nonstructural	JJ
cord-329876-4cgrjnjo	352	7	protein	protein	NN
cord-329876-4cgrjnjo	353	1	nsp14	nsp14	NFP
cord-329876-4cgrjnjo	353	2	as	as	IN
cord-329876-4cgrjnjo	353	3	a	a	DT
cord-329876-4cgrjnjo	353	4	novel	novel	NN
cord-329876-4cgrjnjo	353	5	cap	cap	NN
cord-329876-4cgrjnjo	353	6	N7	N7	NNP
cord-329876-4cgrjnjo	353	7	methyltransferase	methyltransferase	NN
cord-329876-4cgrjnjo	353	8	Structural	structural	JJ
cord-329876-4cgrjnjo	353	9	basis	basis	NN
cord-329876-4cgrjnjo	353	10	for	for	IN
cord-329876-4cgrjnjo	353	11	catalysis	catalysis	NN
cord-329876-4cgrjnjo	353	12	and	and	CC
cord-329876-4cgrjnjo	353	13	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	353	14	recognition	recognition	NN
cord-329876-4cgrjnjo	353	15	by	by	IN
cord-329876-4cgrjnjo	353	16	the	the	DT
cord-329876-4cgrjnjo	353	17	severe	severe	JJ
cord-329876-4cgrjnjo	353	18	acute	acute	JJ
cord-329876-4cgrjnjo	353	19	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	353	20	syndrome	syndrome	NN
cord-329876-4cgrjnjo	353	21	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	353	22	papain	papain	NN
cord-329876-4cgrjnjo	353	23	-	-	HYPH
cord-329876-4cgrjnjo	353	24	like	like	JJ
cord-329876-4cgrjnjo	353	25	protease	protease	NN
cord-329876-4cgrjnjo	353	26	Ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	353	27	-	-	HYPH
cord-329876-4cgrjnjo	353	28	binding	bind	VBG
cord-329876-4cgrjnjo	353	29	domains	domain	NNS
cord-329876-4cgrjnjo	353	30	-	-	:
cord-329876-4cgrjnjo	353	31	from	from	IN
cord-329876-4cgrjnjo	353	32	structures	structure	NNS
cord-329876-4cgrjnjo	353	33	to	to	IN
cord-329876-4cgrjnjo	353	34	functions	function	NNS
cord-329876-4cgrjnjo	353	35	Identification	identification	NN
cord-329876-4cgrjnjo	353	36	of	of	IN
cord-329876-4cgrjnjo	353	37	a	a	DT
cord-329876-4cgrjnjo	353	38	novel	novel	JJ
cord-329876-4cgrjnjo	353	39	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	353	40	in	in	IN
cord-329876-4cgrjnjo	353	41	patients	patient	NNS
cord-329876-4cgrjnjo	353	42	with	with	IN
cord-329876-4cgrjnjo	353	43	severe	severe	JJ
cord-329876-4cgrjnjo	353	44	acute	acute	JJ
cord-329876-4cgrjnjo	353	45	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	353	46	syndrome	syndrome	NN
cord-329876-4cgrjnjo	354	1	In	in	IN
cord-329876-4cgrjnjo	354	2	-	-	HYPH
cord-329876-4cgrjnjo	354	3	vitro	vitro	FW
cord-329876-4cgrjnjo	354	4	renal	renal	JJ
cord-329876-4cgrjnjo	354	5	epithelial	epithelial	JJ
cord-329876-4cgrjnjo	354	6	cell	cell	NN
cord-329876-4cgrjnjo	354	7	infection	infection	NN
cord-329876-4cgrjnjo	354	8	reveals	reveal	VBZ
cord-329876-4cgrjnjo	354	9	a	a	DT
cord-329876-4cgrjnjo	354	10	viral	viral	JJ
cord-329876-4cgrjnjo	354	11	kidney	kidney	NN
cord-329876-4cgrjnjo	354	12	tropism	tropism	NN
cord-329876-4cgrjnjo	354	13	as	as	IN
cord-329876-4cgrjnjo	354	14	a	a	DT
cord-329876-4cgrjnjo	354	15	potential	potential	JJ
cord-329876-4cgrjnjo	354	16	mechanism	mechanism	NN
cord-329876-4cgrjnjo	354	17	for	for	IN
cord-329876-4cgrjnjo	354	18	acute	acute	JJ
cord-329876-4cgrjnjo	354	19	renal	renal	JJ
cord-329876-4cgrjnjo	354	20	failure	failure	NN
cord-329876-4cgrjnjo	354	21	during	during	IN
cord-329876-4cgrjnjo	354	22	Middle	Middle	NNP
cord-329876-4cgrjnjo	354	23	East	East	NNP
cord-329876-4cgrjnjo	354	24	Respiratory	Respiratory	NNP
cord-329876-4cgrjnjo	354	25	Syndrome	Syndrome	NNP
cord-329876-4cgrjnjo	354	26	(	(	-LRB-
cord-329876-4cgrjnjo	354	27	MERS	MERS	NNP
cord-329876-4cgrjnjo	354	28	)	)	-RRB-
cord-329876-4cgrjnjo	354	29	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	354	30	infection	infection	NN
cord-329876-4cgrjnjo	354	31	Features	feature	NNS
cord-329876-4cgrjnjo	354	32	and	and	CC
cord-329876-4cgrjnjo	354	33	development	development	NN
cord-329876-4cgrjnjo	354	34	of	of	IN
cord-329876-4cgrjnjo	354	35	Coot	Coot	NNP
cord-329876-4cgrjnjo	354	36	Allosteric	Allosteric	NNP
cord-329876-4cgrjnjo	354	37	effects	effect	NNS
cord-329876-4cgrjnjo	354	38	of	of	IN
cord-329876-4cgrjnjo	354	39	the	the	DT
cord-329876-4cgrjnjo	354	40	oncogenic	oncogenic	JJ
cord-329876-4cgrjnjo	354	41	RasQ61L	RasQ61L	NNS
cord-329876-4cgrjnjo	354	42	mutant	mutant	NN
cord-329876-4cgrjnjo	354	43	on	on	IN
cord-329876-4cgrjnjo	354	44	Raf	Raf	NNP
cord-329876-4cgrjnjo	354	45	-	-	HYPH
cord-329876-4cgrjnjo	354	46	RBD	RBD	NNP
cord-329876-4cgrjnjo	354	47	Severe	severe	JJ
cord-329876-4cgrjnjo	354	48	acute	acute	JJ
cord-329876-4cgrjnjo	354	49	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	354	50	syndrome	syndrome	NN
cord-329876-4cgrjnjo	354	51	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	354	52	papain	papain	NN
cord-329876-4cgrjnjo	354	53	-	-	HYPH
cord-329876-4cgrjnjo	354	54	like	like	JJ
cord-329876-4cgrjnjo	354	55	protease	protease	NN
cord-329876-4cgrjnjo	354	56	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	354	57	-	-	HYPH
cord-329876-4cgrjnjo	354	58	like	like	JJ
cord-329876-4cgrjnjo	354	59	domain	domain	NN
cord-329876-4cgrjnjo	354	60	and	and	CC
cord-329876-4cgrjnjo	354	61	catalytic	catalytic	JJ
cord-329876-4cgrjnjo	354	62	domain	domain	NN
cord-329876-4cgrjnjo	354	63	regulate	regulate	VBP
cord-329876-4cgrjnjo	354	64	antagonism	antagonism	NN
cord-329876-4cgrjnjo	354	65	of	of	IN
cord-329876-4cgrjnjo	354	66	IRF3	IRF3	NNP
cord-329876-4cgrjnjo	354	67	and	and	CC
cord-329876-4cgrjnjo	355	1	NF	NF	NNP
cord-329876-4cgrjnjo	355	2	-	-	HYPH
cord-329876-4cgrjnjo	355	3	κB	κB	NNP
cord-329876-4cgrjnjo	355	4	signaling	signal	VBG
cord-329876-4cgrjnjo	355	5	The	the	DT
cord-329876-4cgrjnjo	355	6	multifunctional	multifunctional	JJ
cord-329876-4cgrjnjo	355	7	NS1	ns1	NN
cord-329876-4cgrjnjo	355	8	protein	protein	NN
cord-329876-4cgrjnjo	355	9	of	of	IN
cord-329876-4cgrjnjo	355	10	influenza	influenza	NN
cord-329876-4cgrjnjo	355	11	A	a	DT
cord-329876-4cgrjnjo	355	12	viruses	virus	NNS
cord-329876-4cgrjnjo	356	1	A	a	DT
cord-329876-4cgrjnjo	356	2	new	new	JJ
cord-329876-4cgrjnjo	356	3	virus	virus	NN
cord-329876-4cgrjnjo	356	4	isolated	isolate	VBN
cord-329876-4cgrjnjo	356	5	from	from	IN
cord-329876-4cgrjnjo	356	6	the	the	DT
cord-329876-4cgrjnjo	356	7	human	human	JJ
cord-329876-4cgrjnjo	356	8	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	356	9	tract	tract	NN
cord-329876-4cgrjnjo	356	10	Identification	identification	NN
cord-329876-4cgrjnjo	356	11	of	of	IN
cord-329876-4cgrjnjo	356	12	severe	severe	JJ
cord-329876-4cgrjnjo	356	13	acute	acute	JJ
cord-329876-4cgrjnjo	356	14	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	356	15	syndrome	syndrome	NN
cord-329876-4cgrjnjo	356	16	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	356	17	replicase	replicase	NN
cord-329876-4cgrjnjo	356	18	products	product	NNS
cord-329876-4cgrjnjo	356	19	and	and	CC
cord-329876-4cgrjnjo	356	20	characterization	characterization	NN
cord-329876-4cgrjnjo	356	21	of	of	IN
cord-329876-4cgrjnjo	356	22	papain	papain	NN
cord-329876-4cgrjnjo	356	23	-	-	HYPH
cord-329876-4cgrjnjo	356	24	like	like	JJ
cord-329876-4cgrjnjo	356	25	protease	protease	NN
cord-329876-4cgrjnjo	356	26	activity	activity	NN
cord-329876-4cgrjnjo	356	27	Use	use	NN
cord-329876-4cgrjnjo	356	28	of	of	IN
cord-329876-4cgrjnjo	356	29	knowledge	knowledge	NN
cord-329876-4cgrjnjo	356	30	-	-	HYPH
cord-329876-4cgrjnjo	356	31	based	base	VBN
cord-329876-4cgrjnjo	356	32	restraints	restraint	NNS
cord-329876-4cgrjnjo	356	33	in	in	IN
cord-329876-4cgrjnjo	356	34	phenix.refine	phenix.refine	NN
cord-329876-4cgrjnjo	356	35	to	to	TO
cord-329876-4cgrjnjo	356	36	improve	improve	VB
cord-329876-4cgrjnjo	356	37	macromolecular	macromolecular	JJ
cord-329876-4cgrjnjo	356	38	refinement	refinement	NN
cord-329876-4cgrjnjo	356	39	at	at	IN
cord-329876-4cgrjnjo	356	40	low	low	JJ
cord-329876-4cgrjnjo	356	41	resolution	resolution	NN
cord-329876-4cgrjnjo	356	42	From	from	IN
cord-329876-4cgrjnjo	356	43	SARS	SARS	NNP
cord-329876-4cgrjnjo	356	44	to	to	IN
cord-329876-4cgrjnjo	356	45	MERS	MERS	NNP
cord-329876-4cgrjnjo	356	46	:	:	:
cord-329876-4cgrjnjo	357	1	Crystallographic	crystallographic	JJ
cord-329876-4cgrjnjo	357	2	studies	study	NNS
cord-329876-4cgrjnjo	357	3	on	on	IN
cord-329876-4cgrjnjo	357	4	coronaviral	coronaviral	JJ
cord-329876-4cgrjnjo	357	5	proteases	protease	NNS
cord-329876-4cgrjnjo	357	6	enable	enable	VBP
cord-329876-4cgrjnjo	357	7	antiviral	antiviral	JJ
cord-329876-4cgrjnjo	357	8	drug	drug	NN
cord-329876-4cgrjnjo	357	9	design	design	NN
cord-329876-4cgrjnjo	357	10	From	from	IN
cord-329876-4cgrjnjo	357	11	SARS	SARS	NNP
cord-329876-4cgrjnjo	357	12	to	to	IN
cord-329876-4cgrjnjo	357	13	MERS	MERS	NNP
cord-329876-4cgrjnjo	357	14	:	:	:
cord-329876-4cgrjnjo	357	15	10	10	CD
cord-329876-4cgrjnjo	357	16	years	year	NNS
cord-329876-4cgrjnjo	357	17	of	of	IN
cord-329876-4cgrjnjo	357	18	research	research	NN
cord-329876-4cgrjnjo	357	19	on	on	IN
cord-329876-4cgrjnjo	357	20	highly	highly	RB
cord-329876-4cgrjnjo	357	21	pathogenic	pathogenic	JJ
cord-329876-4cgrjnjo	357	22	human	human	JJ
cord-329876-4cgrjnjo	357	23	coronaviruses	coronaviruse	NNS
cord-329876-4cgrjnjo	357	24	Structure	Structure	NNP
cord-329876-4cgrjnjo	357	25	and	and	CC
cord-329876-4cgrjnjo	357	26	mechanisms	mechanism	NNS
cord-329876-4cgrjnjo	357	27	of	of	IN
cord-329876-4cgrjnjo	357	28	the	the	DT
cord-329876-4cgrjnjo	357	29	proteasome	proteasome	VBN
cord-329876-4cgrjnjo	357	30	-	-	HYPH
cord-329876-4cgrjnjo	357	31	associated	associate	VBN
cord-329876-4cgrjnjo	357	32	deubiquitinating	deubiquitinating	NN
cord-329876-4cgrjnjo	357	33	enzyme	enzyme	NN
cord-329876-4cgrjnjo	358	1	USP14	usp14	DT
cord-329876-4cgrjnjo	358	2	Inference	inference	NN
cord-329876-4cgrjnjo	358	3	of	of	IN
cord-329876-4cgrjnjo	358	4	macromolecular	macromolecular	JJ
cord-329876-4cgrjnjo	358	5	assemblies	assembly	NNS
cord-329876-4cgrjnjo	358	6	from	from	IN
cord-329876-4cgrjnjo	358	7	crystalline	crystalline	JJ
cord-329876-4cgrjnjo	358	8	state	state	NN
cord-329876-4cgrjnjo	359	1	A	a	DT
cord-329876-4cgrjnjo	359	2	novel	novel	JJ
cord-329876-4cgrjnjo	359	3	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	359	4	associated	associate	VBN
cord-329876-4cgrjnjo	359	5	with	with	IN
cord-329876-4cgrjnjo	359	6	severe	severe	JJ
cord-329876-4cgrjnjo	359	7	acute	acute	JJ
cord-329876-4cgrjnjo	359	8	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	359	9	syndrome	syndrome	NN
cord-329876-4cgrjnjo	359	10	Newly	newly	RB
cord-329876-4cgrjnjo	359	11	discovered	discover	VBD
cord-329876-4cgrjnjo	359	12	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	359	13	as	as	IN
cord-329876-4cgrjnjo	359	14	the	the	DT
cord-329876-4cgrjnjo	359	15	primary	primary	JJ
cord-329876-4cgrjnjo	359	16	cause	cause	NN
cord-329876-4cgrjnjo	359	17	of	of	IN
cord-329876-4cgrjnjo	359	18	severe	severe	JJ
cord-329876-4cgrjnjo	359	19	acute	acute	JJ
cord-329876-4cgrjnjo	359	20	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	359	21	syndrome	syndrome	NN
cord-329876-4cgrjnjo	359	22	Inhibitor	Inhibitor	NNP
cord-329876-4cgrjnjo	359	23	recognition	recognition	NN
cord-329876-4cgrjnjo	359	24	specificity	specificity	NN
cord-329876-4cgrjnjo	359	25	of	of	IN
cord-329876-4cgrjnjo	359	26	MERS	MERS	NNP
cord-329876-4cgrjnjo	359	27	-	-	HYPH
cord-329876-4cgrjnjo	359	28	CoV	CoV	NNP
cord-329876-4cgrjnjo	359	29	papain	papain	NN
cord-329876-4cgrjnjo	359	30	-	-	HYPH
cord-329876-4cgrjnjo	359	31	like	like	JJ
cord-329876-4cgrjnjo	359	32	protease	protease	NN
cord-329876-4cgrjnjo	359	33	may	may	MD
cord-329876-4cgrjnjo	359	34	differ	differ	VB
cord-329876-4cgrjnjo	359	35	from	from	IN
cord-329876-4cgrjnjo	359	36	that	that	DT
cord-329876-4cgrjnjo	359	37	of	of	IN
cord-329876-4cgrjnjo	359	38	SARS	SARS	NNP
cord-329876-4cgrjnjo	359	39	-	-	HYPH
cord-329876-4cgrjnjo	359	40	CoV	CoV	NNP
cord-329876-4cgrjnjo	359	41	Crystal	Crystal	NNP
cord-329876-4cgrjnjo	359	42	structure	structure	NN
cord-329876-4cgrjnjo	359	43	of	of	IN
cord-329876-4cgrjnjo	359	44	the	the	DT
cord-329876-4cgrjnjo	359	45	papain	papain	NN
cord-329876-4cgrjnjo	359	46	-	-	HYPH
cord-329876-4cgrjnjo	359	47	like	like	JJ
cord-329876-4cgrjnjo	359	48	protease	protease	NN
cord-329876-4cgrjnjo	359	49	of	of	IN
cord-329876-4cgrjnjo	359	50	MERScoronavirus	MERScoronavirus	NNP
cord-329876-4cgrjnjo	359	51	reveals	reveal	VBZ
cord-329876-4cgrjnjo	359	52	unusual	unusual	JJ
cord-329876-4cgrjnjo	359	53	,	,	,
cord-329876-4cgrjnjo	359	54	potentially	potentially	RB
cord-329876-4cgrjnjo	359	55	druggable	druggable	JJ
cord-329876-4cgrjnjo	359	56	active	active	JJ
cord-329876-4cgrjnjo	359	57	-	-	HYPH
cord-329876-4cgrjnjo	359	58	site	site	NN
cord-329876-4cgrjnjo	359	59	features	feature	VBZ
cord-329876-4cgrjnjo	359	60	Immunity	immunity	NN
cord-329876-4cgrjnjo	359	61	by	by	IN
cord-329876-4cgrjnjo	359	62	ubiquitylation	ubiquitylation	NN
cord-329876-4cgrjnjo	359	63	:	:	:
cord-329876-4cgrjnjo	359	64	a	a	DT
cord-329876-4cgrjnjo	359	65	reversible	reversible	JJ
cord-329876-4cgrjnjo	359	66	process	process	NN
cord-329876-4cgrjnjo	359	67	of	of	IN
cord-329876-4cgrjnjo	359	68	modification	modification	NN
cord-329876-4cgrjnjo	359	69	Message	message	NN
cord-329876-4cgrjnjo	359	70	in	in	IN
cord-329876-4cgrjnjo	359	71	a	a	DT
cord-329876-4cgrjnjo	359	72	bottle	bottle	NN
cord-329876-4cgrjnjo	359	73	:	:	:
cord-329876-4cgrjnjo	359	74	lessons	lesson	NNS
cord-329876-4cgrjnjo	359	75	learned	learn	VBN
cord-329876-4cgrjnjo	359	76	from	from	IN
cord-329876-4cgrjnjo	359	77	antagonism	antagonism	NN
cord-329876-4cgrjnjo	359	78	of	of	IN
cord-329876-4cgrjnjo	359	79	STING	sting	NN
cord-329876-4cgrjnjo	359	80	signalling	signal	VBG
cord-329876-4cgrjnjo	359	81	during	during	IN
cord-329876-4cgrjnjo	359	82	RNA	RNA	NNP
cord-329876-4cgrjnjo	359	83	virus	virus	NN
cord-329876-4cgrjnjo	359	84	infection	infection	NN
cord-329876-4cgrjnjo	359	85	Growth	growth	NN
cord-329876-4cgrjnjo	359	86	in	in	IN
cord-329876-4cgrjnjo	359	87	suckling	suckle	VBG
cord-329876-4cgrjnjo	359	88	-	-	HYPH
cord-329876-4cgrjnjo	359	89	mouse	mouse	NN
cord-329876-4cgrjnjo	359	90	brain	brain	NN
cord-329876-4cgrjnjo	359	91	of	of	IN
cord-329876-4cgrjnjo	359	92	"	"	``
cord-329876-4cgrjnjo	359	93	IBV	IBV	NNP
cord-329876-4cgrjnjo	359	94	-	-	HYPH
cord-329876-4cgrjnjo	359	95	like	like	JJ
cord-329876-4cgrjnjo	359	96	"	"	''
cord-329876-4cgrjnjo	359	97	viruses	virus	NNS
cord-329876-4cgrjnjo	359	98	from	from	IN
cord-329876-4cgrjnjo	359	99	patients	patient	NNS
cord-329876-4cgrjnjo	359	100	with	with	IN
cord-329876-4cgrjnjo	359	101	upper	upper	JJ
cord-329876-4cgrjnjo	359	102	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	359	103	tract	tract	NN
cord-329876-4cgrjnjo	359	104	disease	disease	NN
cord-329876-4cgrjnjo	359	105	MERS	MERS	NNP
cord-329876-4cgrjnjo	359	106	-	-	HYPH
cord-329876-4cgrjnjo	359	107	CoV	CoV	NNP
cord-329876-4cgrjnjo	359	108	papain	papain	NN
cord-329876-4cgrjnjo	359	109	-	-	HYPH
cord-329876-4cgrjnjo	359	110	like	like	JJ
cord-329876-4cgrjnjo	359	111	protease	protease	NN
cord-329876-4cgrjnjo	359	112	has	have	VBZ
cord-329876-4cgrjnjo	359	113	delSGylating	delsgylate	VBG
cord-329876-4cgrjnjo	359	114	and	and	CC
cord-329876-4cgrjnjo	359	115	deubiquitinating	deubiquitinating	NN
cord-329876-4cgrjnjo	359	116	activities	activity	NNS
cord-329876-4cgrjnjo	360	1	Murine	murine	JJ
cord-329876-4cgrjnjo	360	2	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	360	3	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	360	4	-	-	HYPH
cord-329876-4cgrjnjo	360	5	like	like	JJ
cord-329876-4cgrjnjo	360	6	domain	domain	NN
cord-329876-4cgrjnjo	360	7	is	be	VBZ
cord-329876-4cgrjnjo	360	8	important	important	JJ
cord-329876-4cgrjnjo	360	9	for	for	IN
cord-329876-4cgrjnjo	360	10	papain	papain	NN
cord-329876-4cgrjnjo	360	11	-	-	HYPH
cord-329876-4cgrjnjo	360	12	like	like	JJ
cord-329876-4cgrjnjo	360	13	protease	protease	NN
cord-329876-4cgrjnjo	360	14	stability	stability	NN
cord-329876-4cgrjnjo	360	15	and	and	CC
cord-329876-4cgrjnjo	360	16	viral	viral	JJ
cord-329876-4cgrjnjo	360	17	pathogenesis	pathogenesis	NN
cord-329876-4cgrjnjo	360	18	Facilities	facility	NNS
cord-329876-4cgrjnjo	360	19	for	for	IN
cord-329876-4cgrjnjo	360	20	macromolecular	macromolecular	JJ
cord-329876-4cgrjnjo	360	21	crystallography	crystallography	NN
cord-329876-4cgrjnjo	360	22	at	at	IN
cord-329876-4cgrjnjo	360	23	the	the	DT
cord-329876-4cgrjnjo	360	24	Helmholtz	Helmholtz	NNP
cord-329876-4cgrjnjo	360	25	-	-	HYPH
cord-329876-4cgrjnjo	360	26	Zentrum	Zentrum	NNP
cord-329876-4cgrjnjo	360	27	Berlin	Berlin	NNP
cord-329876-4cgrjnjo	360	28	Coronavirus	Coronavirus	NNP
cord-329876-4cgrjnjo	360	29	as	as	IN
cord-329876-4cgrjnjo	360	30	a	a	DT
cord-329876-4cgrjnjo	360	31	possible	possible	JJ
cord-329876-4cgrjnjo	360	32	cause	cause	NN
cord-329876-4cgrjnjo	360	33	of	of	IN
cord-329876-4cgrjnjo	360	34	severe	severe	JJ
cord-329876-4cgrjnjo	360	35	acute	acute	JJ
cord-329876-4cgrjnjo	360	36	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	360	37	syndrome	syndrome	NN
cord-329876-4cgrjnjo	360	38	Crystal	Crystal	NNP
cord-329876-4cgrjnjo	360	39	structure	structure	NN
cord-329876-4cgrjnjo	360	40	of	of	IN
cord-329876-4cgrjnjo	360	41	USP7	USP7	NNP
cord-329876-4cgrjnjo	360	42	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	360	43	-	-	HYPH
cord-329876-4cgrjnjo	360	44	like	like	JJ
cord-329876-4cgrjnjo	360	45	domains	domain	NNS
cord-329876-4cgrjnjo	360	46	with	with	IN
cord-329876-4cgrjnjo	360	47	an	an	DT
cord-329876-4cgrjnjo	360	48	ICP0	ICP0	NNP
cord-329876-4cgrjnjo	360	49	peptide	peptide	NN
cord-329876-4cgrjnjo	360	50	reveals	reveal	VBZ
cord-329876-4cgrjnjo	360	51	a	a	DT
cord-329876-4cgrjnjo	360	52	novel	novel	NN
cord-329876-4cgrjnjo	360	53	mechanism	mechanism	NN
cord-329876-4cgrjnjo	360	54	used	use	VBN
cord-329876-4cgrjnjo	360	55	by	by	IN
cord-329876-4cgrjnjo	360	56	viral	viral	JJ
cord-329876-4cgrjnjo	360	57	and	and	CC
cord-329876-4cgrjnjo	360	58	cellular	cellular	JJ
cord-329876-4cgrjnjo	360	59	proteins	protein	NNS
cord-329876-4cgrjnjo	360	60	to	to	TO
cord-329876-4cgrjnjo	360	61	target	target	VB
cord-329876-4cgrjnjo	360	62	USP7	USP7	NNP
cord-329876-4cgrjnjo	360	63	Structural	structural	JJ
cord-329876-4cgrjnjo	360	64	basis	basis	NN
cord-329876-4cgrjnjo	360	65	for	for	IN
cord-329876-4cgrjnjo	360	66	the	the	DT
cord-329876-4cgrjnjo	360	67	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	360	68	-	-	HYPH
cord-329876-4cgrjnjo	360	69	linkage	linkage	NN
cord-329876-4cgrjnjo	360	70	specificity	specificity	NN
cord-329876-4cgrjnjo	360	71	and	and	CC
cord-329876-4cgrjnjo	360	72	deISGylating	deisgylate	VBG
cord-329876-4cgrjnjo	360	73	activity	activity	NN
cord-329876-4cgrjnjo	360	74	of	of	IN
cord-329876-4cgrjnjo	360	75	SARS	SARS	NNP
cord-329876-4cgrjnjo	360	76	-	-	HYPH
cord-329876-4cgrjnjo	360	77	CoV	CoV	NNP
cord-329876-4cgrjnjo	360	78	papain	papain	NN
cord-329876-4cgrjnjo	360	79	-	-	HYPH
cord-329876-4cgrjnjo	360	80	like	like	JJ
cord-329876-4cgrjnjo	360	81	protease	protease	NN
cord-329876-4cgrjnjo	360	82	Identification	identification	NN
cord-329876-4cgrjnjo	360	83	of	of	IN
cord-329876-4cgrjnjo	360	84	a	a	DT
cord-329876-4cgrjnjo	360	85	new	new	JJ
cord-329876-4cgrjnjo	360	86	human	human	JJ
cord-329876-4cgrjnjo	360	87	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	360	88	Structure	Structure	NNP
cord-329876-4cgrjnjo	360	89	of	of	IN
cord-329876-4cgrjnjo	360	90	ubiquitin	ubiquitin	NN
cord-329876-4cgrjnjo	360	91	refined	refine	VBN
cord-329876-4cgrjnjo	360	92	at	at	IN
cord-329876-4cgrjnjo	360	93	1.8	1.8	CD
cord-329876-4cgrjnjo	360	94	Å	å	NN
cord-329876-4cgrjnjo	360	95	resolution	resolution	NN
cord-329876-4cgrjnjo	361	1	Recent	recent	JJ
cord-329876-4cgrjnjo	361	2	progress	progress	NN
cord-329876-4cgrjnjo	361	3	in	in	IN
cord-329876-4cgrjnjo	361	4	the	the	DT
cord-329876-4cgrjnjo	361	5	discovery	discovery	NN
cord-329876-4cgrjnjo	361	6	of	of	IN
cord-329876-4cgrjnjo	361	7	inhibitors	inhibitor	NNS
cord-329876-4cgrjnjo	361	8	targeting	target	VBG
cord-329876-4cgrjnjo	361	9	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	361	10	proteases	protease	NNS
cord-329876-4cgrjnjo	361	11	On	on	IN
cord-329876-4cgrjnjo	361	12	the	the	DT
cord-329876-4cgrjnjo	361	13	use	use	NN
cord-329876-4cgrjnjo	361	14	of	of	IN
cord-329876-4cgrjnjo	361	15	the	the	DT
cord-329876-4cgrjnjo	361	16	merging	merge	VBG
cord-329876-4cgrjnjo	361	17	R	r	NN
cord-329876-4cgrjnjo	361	18	factor	factor	NN
cord-329876-4cgrjnjo	361	19	as	as	IN
cord-329876-4cgrjnjo	361	20	a	a	DT
cord-329876-4cgrjnjo	361	21	quality	quality	NN
cord-329876-4cgrjnjo	361	22	indicator	indicator	NN
cord-329876-4cgrjnjo	361	23	for	for	IN
cord-329876-4cgrjnjo	361	24	X	x	NN
cord-329876-4cgrjnjo	361	25	-	-	NN
cord-329876-4cgrjnjo	361	26	ray	ray	NN
cord-329876-4cgrjnjo	361	27	data	datum	NNS
cord-329876-4cgrjnjo	362	1	Papain	papain	NN
cord-329876-4cgrjnjo	362	2	-	-	HYPH
cord-329876-4cgrjnjo	362	3	like	like	JJ
cord-329876-4cgrjnjo	362	4	protease	protease	NN
cord-329876-4cgrjnjo	362	5	1	1	CD
cord-329876-4cgrjnjo	362	6	from	from	IN
cord-329876-4cgrjnjo	362	7	transmissible	transmissible	JJ
cord-329876-4cgrjnjo	362	8	gastroenteritis	gastroenteritis	NN
cord-329876-4cgrjnjo	362	9	virus	virus	NN
cord-329876-4cgrjnjo	362	10	:	:	:
cord-329876-4cgrjnjo	363	1	crystal	crystal	NNP
cord-329876-4cgrjnjo	363	2	structure	structure	NN
cord-329876-4cgrjnjo	363	3	and	and	CC
cord-329876-4cgrjnjo	363	4	enzymatic	enzymatic	JJ
cord-329876-4cgrjnjo	363	5	activity	activity	NN
cord-329876-4cgrjnjo	363	6	toward	toward	IN
cord-329876-4cgrjnjo	363	7	viral	viral	JJ
cord-329876-4cgrjnjo	363	8	and	and	CC
cord-329876-4cgrjnjo	363	9	cellular	cellular	JJ
cord-329876-4cgrjnjo	363	10	substrates	substrate	NNS
cord-329876-4cgrjnjo	363	11	Characterization	characterization	NN
cord-329876-4cgrjnjo	363	12	and	and	CC
cord-329876-4cgrjnjo	363	13	complete	complete	JJ
cord-329876-4cgrjnjo	363	14	genome	genome	NN
cord-329876-4cgrjnjo	363	15	sequence	sequence	NN
cord-329876-4cgrjnjo	363	16	of	of	IN
cord-329876-4cgrjnjo	363	17	a	a	DT
cord-329876-4cgrjnjo	363	18	novel	novel	JJ
cord-329876-4cgrjnjo	363	19	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	363	20	,	,	,
cord-329876-4cgrjnjo	363	21	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	363	22	HKU1	HKU1	NNP
cord-329876-4cgrjnjo	363	23	,	,	,
cord-329876-4cgrjnjo	363	24	from	from	IN
cord-329876-4cgrjnjo	363	25	patients	patient	NNS
cord-329876-4cgrjnjo	363	26	with	with	IN
cord-329876-4cgrjnjo	363	27	pneumonia	pneumonia	NN
cord-329876-4cgrjnjo	363	28	Proteolytic	Proteolytic	NNP
cord-329876-4cgrjnjo	363	29	processing	processing	NN
cord-329876-4cgrjnjo	363	30	,	,	,
cord-329876-4cgrjnjo	363	31	deubiquitinase	deubiquitinase	NN
cord-329876-4cgrjnjo	363	32	and	and	CC
cord-329876-4cgrjnjo	363	33	interferon	interferon	NN
cord-329876-4cgrjnjo	363	34	antagonist	antagonist	NN
cord-329876-4cgrjnjo	363	35	activities	activity	NNS
cord-329876-4cgrjnjo	363	36	of	of	IN
cord-329876-4cgrjnjo	363	37	Middle	Middle	NNP
cord-329876-4cgrjnjo	363	38	East	East	NNP
cord-329876-4cgrjnjo	363	39	respiratory	respiratory	JJ
cord-329876-4cgrjnjo	363	40	syndrome	syndrome	NN
cord-329876-4cgrjnjo	363	41	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	363	42	papain	papain	NN
cord-329876-4cgrjnjo	363	43	-	-	HYPH
cord-329876-4cgrjnjo	363	44	like	like	JJ
cord-329876-4cgrjnjo	363	45	protease	protease	NN
cord-329876-4cgrjnjo	363	46	Isolation	isolation	NN
cord-329876-4cgrjnjo	363	47	of	of	IN
cord-329876-4cgrjnjo	363	48	a	a	DT
cord-329876-4cgrjnjo	363	49	novel	novel	JJ
cord-329876-4cgrjnjo	363	50	coronavirus	coronavirus	NN
cord-329876-4cgrjnjo	363	51	from	from	IN
cord-329876-4cgrjnjo	363	52	a	a	DT
cord-329876-4cgrjnjo	363	53	man	man	NN
cord-329876-4cgrjnjo	363	54	with	with	IN
cord-329876-4cgrjnjo	363	55	pneumonia	pneumonia	NN
cord-329876-4cgrjnjo	363	56	in	in	IN
cord-329876-4cgrjnjo	363	57	Saudi	Saudi	NNP
cord-329876-4cgrjnjo	363	58	Arabia	Arabia	NNP
cord-329876-4cgrjnjo	363	59	Technical	Technical	NNP
cord-329876-4cgrjnjo	363	60	assistance	assistance	NN
cord-329876-4cgrjnjo	363	61	by	by	IN
cord-329876-4cgrjnjo	363	62	Susanne	Susanne	NNP
cord-329876-4cgrjnjo	363	63	Zoske	Zoske	NNP
cord-329876-4cgrjnjo	363	64	is	be	VBZ
cord-329876-4cgrjnjo	363	65	gratefully	gratefully	RB
cord-329876-4cgrjnjo	363	66	acknowledged	acknowledge	VBN
cord-329876-4cgrjnjo	363	67	.	.	.
cord-329876-4cgrjnjo	364	1	We	-PRON-	PRP
cord-329876-4cgrjnjo	364	2	thank	thank	VBP
cord-329876-4cgrjnjo	364	3	Stefan	Stefan	NNP
cord-329876-4cgrjnjo	364	4	Anemüller	Anemüller	NNP
cord-329876-4cgrjnjo	364	5	for	for	IN
cord-329876-4cgrjnjo	364	6	discussion	discussion	NN
cord-329876-4cgrjnjo	364	7	.	.	.
cord-329876-4cgrjnjo	365	1	We	-PRON-	PRP
cord-329876-4cgrjnjo	365	2	also	also	RB
cord-329876-4cgrjnjo	365	3	acknowledge	acknowledge	VBP
cord-329876-4cgrjnjo	365	4	access	access	NN
cord-329876-4cgrjnjo	365	5	to	to	IN
cord-329876-4cgrjnjo	365	6	beamline	beamline	NN
cord-329876-4cgrjnjo	365	7	BL14.2	bl14.2	NN
cord-329876-4cgrjnjo	365	8	operated	operate	VBN
cord-329876-4cgrjnjo	365	9	by	by	IN
cord-329876-4cgrjnjo	365	10	the	the	DT
cord-329876-4cgrjnjo	365	11	Helmholtz	Helmholtz	NNP
cord-329876-4cgrjnjo	365	12	-	-	HYPH
cord-329876-4cgrjnjo	365	13	Zentrum	Zentrum	NNP
cord-329876-4cgrjnjo	365	14	Berlin	Berlin	NNP
cord-329876-4cgrjnjo	365	15	at	at	IN
cord-329876-4cgrjnjo	365	16	the	the	DT
cord-329876-4cgrjnjo	365	17	BESSY	BESSY	NNP
cord-329876-4cgrjnjo	365	18	II	II	NNP
cord-329876-4cgrjnjo	365	19	electron	electron	NN
cord-329876-4cgrjnjo	365	20	storage	storage	NN
cord-329876-4cgrjnjo	365	21	ring	ring	NN
cord-329876-4cgrjnjo	365	22	(	(	-LRB-
cord-329876-4cgrjnjo	365	23	Berlin	Berlin	NNP
cord-329876-4cgrjnjo	365	24	-	-	HYPH
cord-329876-4cgrjnjo	365	25	Adlershof	Adlershof	NNP
cord-329876-4cgrjnjo	365	26	,	,	,
cord-329876-4cgrjnjo	365	27	Germany	Germany	NNP
cord-329876-4cgrjnjo	365	28	)	)	-RRB-
cord-329876-4cgrjnjo	365	29	.	.	.
cord-329876-4cgrjnjo	366	1	This	this	DT
cord-329876-4cgrjnjo	366	2	work	work	NN
cord-329876-4cgrjnjo	366	3	was	be	VBD
cord-329876-4cgrjnjo	366	4	supported	support	VBN
cord-329876-4cgrjnjo	366	5	by	by	IN
cord-329876-4cgrjnjo	366	6	the	the	DT
cord-329876-4cgrjnjo	366	7	European	European	NNP
cord-329876-4cgrjnjo	366	8	Commission	Commission	NNP
cord-329876-4cgrjnjo	366	9	through	through	IN
cord-329876-4cgrjnjo	366	10	its	-PRON-	PRP$
cord-329876-4cgrjnjo	366	11	"	"	``
cord-329876-4cgrjnjo	366	12	SILVER	silver	NN
cord-329876-4cgrjnjo	366	13	"	"	''
cord-329876-4cgrjnjo	366	14	project	project	NN
cord-329876-4cgrjnjo	366	15	(	(	-LRB-
cord-329876-4cgrjnjo	366	16	contract	contract	NN
cord-329876-4cgrjnjo	366	17	no	no	UH
cord-329876-4cgrjnjo	366	18	.	.	.
cord-329876-4cgrjnjo	367	1	HEALTH	health	NN
cord-329876-4cgrjnjo	367	2	-	-	HYPH
cord-329876-4cgrjnjo	367	3	F3	F3	NNP
cord-329876-4cgrjnjo	367	4	-	-	HYPH
cord-329876-4cgrjnjo	367	5	2010	2010	CD
cord-329876-4cgrjnjo	367	6	-	-	CD
cord-329876-4cgrjnjo	367	7	260644	260644	CD
cord-329876-4cgrjnjo	367	8	)	)	-RRB-
cord-329876-4cgrjnjo	368	1	and	and	CC
cord-329876-4cgrjnjo	368	2	by	by	IN
cord-329876-4cgrjnjo	368	3	the	the	DT
cord-329876-4cgrjnjo	368	4	German	German	NNP
cord-329876-4cgrjnjo	368	5	Center	Center	NNP
cord-329876-4cgrjnjo	368	6	for	for	IN
cord-329876-4cgrjnjo	368	7	Infection	Infection	NNP
cord-329876-4cgrjnjo	368	8	Research	Research	NNP
cord-329876-4cgrjnjo	368	9	(	(	-LRB-
cord-329876-4cgrjnjo	368	10	DZIF	DZIF	NNP
cord-329876-4cgrjnjo	368	11	)	)	-RRB-
cord-329876-4cgrjnjo	368	12	.	.	.
cord-329876-4cgrjnjo	369	1	RH	RH	NNP
cord-329876-4cgrjnjo	369	2	acknowledges	acknowledge	VBZ
cord-329876-4cgrjnjo	369	3	support	support	NN
cord-329876-4cgrjnjo	369	4	by	by	IN
cord-329876-4cgrjnjo	369	5	the	the	DT
cord-329876-4cgrjnjo	369	6	DFG	DFG	NNP
cord-329876-4cgrjnjo	369	7	Cluster	Cluster	NNP
cord-329876-4cgrjnjo	369	8	of	of	IN
cord-329876-4cgrjnjo	369	9	Excellence	Excellence	NNP
cord-329876-4cgrjnjo	369	10	"	"	''
cord-329876-4cgrjnjo	369	11	Inflammation	inflammation	NN
cord-329876-4cgrjnjo	369	12	at	at	IN
cord-329876-4cgrjnjo	369	13	Interfaces	Interfaces	NNPS
cord-329876-4cgrjnjo	369	14	"	"	''
cord-329876-4cgrjnjo	369	15	(	(	-LRB-
cord-329876-4cgrjnjo	369	16	EXC	EXC	NNP
cord-329876-4cgrjnjo	369	17	306	306	CD
cord-329876-4cgrjnjo	369	18	)	)	-RRB-
cord-329876-4cgrjnjo	370	1	This	this	DT
cord-329876-4cgrjnjo	370	2	article	article	NN
cord-329876-4cgrjnjo	370	3	does	do	VBZ
cord-329876-4cgrjnjo	370	4	not	not	RB
cord-329876-4cgrjnjo	370	5	contain	contain	VB
cord-329876-4cgrjnjo	370	6	any	any	DT
cord-329876-4cgrjnjo	370	7	studies	study	NNS
cord-329876-4cgrjnjo	370	8	with	with	IN
cord-329876-4cgrjnjo	370	9	human	human	JJ
cord-329876-4cgrjnjo	370	10	or	or	CC
cord-329876-4cgrjnjo	370	11	animal	animal	NN
cord-329876-4cgrjnjo	370	12	subjects	subject	NNS
cord-329876-4cgrjnjo	370	13	.	.	.
cord-329876-4cgrjnjo	371	1	Both	both	DT
cord-329876-4cgrjnjo	371	2	authors	author	NNS
cord-329876-4cgrjnjo	371	3	declare	declare	VBP
cord-329876-4cgrjnjo	371	4	no	no	DT
cord-329876-4cgrjnjo	371	5	competing	compete	VBG
cord-329876-4cgrjnjo	371	6	interest	interest	NN
cord-329876-4cgrjnjo	371	7	.	.	.
cord-329876-4cgrjnjo	372	1	JL	JL	NNP
cord-329876-4cgrjnjo	372	2	and	and	CC
cord-329876-4cgrjnjo	372	3	RH	RH	NNP
cord-329876-4cgrjnjo	372	4	designed	design	VBD
cord-329876-4cgrjnjo	372	5	all	all	DT
cord-329876-4cgrjnjo	372	6	experiments	experiment	NNS
cord-329876-4cgrjnjo	372	7	.	.	.
cord-329876-4cgrjnjo	373	1	JL	JL	NNP
cord-329876-4cgrjnjo	373	2	performed	perform	VBD
cord-329876-4cgrjnjo	373	3	the	the	DT
cord-329876-4cgrjnjo	373	4	experiments	experiment	NNS
cord-329876-4cgrjnjo	373	5	.	.	.
cord-329876-4cgrjnjo	374	1	JL	JL	NNP
cord-329876-4cgrjnjo	374	2	and	and	CC
cord-329876-4cgrjnjo	374	3	RH	RH	NNP
cord-329876-4cgrjnjo	374	4	analyzed	analyze	VBD
cord-329876-4cgrjnjo	374	5	all	all	DT
cord-329876-4cgrjnjo	374	6	data	datum	NNS
cord-329876-4cgrjnjo	374	7	.	.	.
cord-329876-4cgrjnjo	375	1	JL	JL	NNP
cord-329876-4cgrjnjo	375	2	and	and	CC
cord-329876-4cgrjnjo	375	3	RH	RH	NNP
cord-329876-4cgrjnjo	375	4	wrote	write	VBD
cord-329876-4cgrjnjo	375	5	the	the	DT
cord-329876-4cgrjnjo	375	6	manuscript	manuscript	NN
cord-329876-4cgrjnjo	375	7	.	.	.
cord-329876-4cgrjnjo	376	1	Supplementary	supplementary	JJ
cord-329876-4cgrjnjo	376	2	figure	figure	NN
cord-329876-4cgrjnjo	376	3	and	and	CC
cord-329876-4cgrjnjo	376	4	table	table	NN
cord-329876-4cgrjnjo	376	5	are	be	VBP
cord-329876-4cgrjnjo	376	6	available	available	JJ
cord-329876-4cgrjnjo	376	7	on	on	IN
cord-329876-4cgrjnjo	376	8	the	the	DT
cord-329876-4cgrjnjo	376	9	websites	website	NNS
cord-329876-4cgrjnjo	376	10	of	of	IN
cord-329876-4cgrjnjo	376	11	Virologica	Virologica	NNP
cord-329876-4cgrjnjo	376	12	Sinica	Sinica	NNP
cord-329876-4cgrjnjo	376	13	:	:	:
cord-329876-4cgrjnjo	376	14	www.virosin.org	www.virosin.org	NN
cord-329876-4cgrjnjo	376	15	;	;	:
cord-329876-4cgrjnjo	376	16	link	link	NN
cord-329876-4cgrjnjo	376	17	.	.	.
cord-329876-4cgrjnjo	377	1	springer.com/	springer.com/	NNP
cord-329876-4cgrjnjo	377	2	journal/12250	journal/12250	NNP
cord-329876-4cgrjnjo	377	3	.	.	.