id sid tid token lemma pos cord-307853-m1q1sjr4 1 1 key key JJ cord-307853-m1q1sjr4 2 1 : : : cord-307853-m1q1sjr4 2 2 cord-307853-m1q1sjr4 cord-307853-m1q1sjr4 NN cord-307853-m1q1sjr4 2 3 authors author NNS cord-307853-m1q1sjr4 2 4 : : : cord-307853-m1q1sjr4 2 5 Majumder Majumder NNP cord-307853-m1q1sjr4 2 6 , , , cord-307853-m1q1sjr4 2 7 Satyabrata Satyabrata NNP cord-307853-m1q1sjr4 2 8 ; ; : cord-307853-m1q1sjr4 2 9 Chaudhuri Chaudhuri NNP cord-307853-m1q1sjr4 2 10 , , , cord-307853-m1q1sjr4 2 11 Dwaipayan Dwaipayan NNP cord-307853-m1q1sjr4 2 12 ; ; : cord-307853-m1q1sjr4 2 13 Datta Datta NNP cord-307853-m1q1sjr4 2 14 , , , cord-307853-m1q1sjr4 2 15 Joyeeta Joyeeta NNP cord-307853-m1q1sjr4 2 16 ; ; : cord-307853-m1q1sjr4 2 17 Giri Giri NNP cord-307853-m1q1sjr4 2 18 , , , cord-307853-m1q1sjr4 2 19 Kalyan Kalyan NNP cord-307853-m1q1sjr4 2 20 title title NN cord-307853-m1q1sjr4 2 21 : : : cord-307853-m1q1sjr4 3 1 Exploring explore VBG cord-307853-m1q1sjr4 3 2 the the DT cord-307853-m1q1sjr4 3 3 intrinsic intrinsic JJ cord-307853-m1q1sjr4 3 4 dynamics dynamic NNS cord-307853-m1q1sjr4 3 5 of of IN cord-307853-m1q1sjr4 3 6 SARS SARS NNP cord-307853-m1q1sjr4 3 7 - - HYPH cord-307853-m1q1sjr4 3 8 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 3 9 , , , cord-307853-m1q1sjr4 3 10 SARS SARS NNP cord-307853-m1q1sjr4 3 11 - - HYPH cord-307853-m1q1sjr4 3 12 CoV CoV NNP cord-307853-m1q1sjr4 3 13 and and CC cord-307853-m1q1sjr4 3 14 MERS MERS NNP cord-307853-m1q1sjr4 3 15 - - HYPH cord-307853-m1q1sjr4 3 16 CoV cov NN cord-307853-m1q1sjr4 3 17 spike spike NN cord-307853-m1q1sjr4 3 18 glycoprotein glycoprotein NN cord-307853-m1q1sjr4 3 19 through through IN cord-307853-m1q1sjr4 3 20 normal normal JJ cord-307853-m1q1sjr4 3 21 mode mode NN cord-307853-m1q1sjr4 3 22 analysis analysis NN cord-307853-m1q1sjr4 3 23 using use VBG cord-307853-m1q1sjr4 3 24 anisotropic anisotropic JJ cord-307853-m1q1sjr4 3 25 network network NN cord-307853-m1q1sjr4 3 26 model model NN cord-307853-m1q1sjr4 3 27 date date NN cord-307853-m1q1sjr4 3 28 : : : cord-307853-m1q1sjr4 3 29 2020 2020 CD cord-307853-m1q1sjr4 3 30 - - SYM cord-307853-m1q1sjr4 3 31 10 10 CD cord-307853-m1q1sjr4 3 32 - - SYM cord-307853-m1q1sjr4 3 33 16 16 CD cord-307853-m1q1sjr4 3 34 journal journal NN cord-307853-m1q1sjr4 3 35 : : : cord-307853-m1q1sjr4 4 1 J J NNP cord-307853-m1q1sjr4 4 2 Mol Mol NNP cord-307853-m1q1sjr4 4 3 Graph Graph NNP cord-307853-m1q1sjr4 4 4 Model Model NNP cord-307853-m1q1sjr4 4 5 DOI DOI NNP cord-307853-m1q1sjr4 4 6 : : : cord-307853-m1q1sjr4 4 7 10.1016 10.1016 CD cord-307853-m1q1sjr4 4 8 / / SYM cord-307853-m1q1sjr4 4 9 j.jmgm.2020.107778 j.jmgm.2020.107778 NNS cord-307853-m1q1sjr4 4 10 sha sha NNP cord-307853-m1q1sjr4 4 11 : : : cord-307853-m1q1sjr4 4 12 fa06982dd080f2ceacfda2e0950f2b8dd9e40424 fa06982dd080f2ceacfda2e0950f2b8dd9e40424 NNP cord-307853-m1q1sjr4 4 13 doc_id doc_id CD cord-307853-m1q1sjr4 4 14 : : : cord-307853-m1q1sjr4 4 15 307853 307853 CD cord-307853-m1q1sjr4 4 16 cord_uid cord_uid NNS cord-307853-m1q1sjr4 4 17 : : : cord-307853-m1q1sjr4 4 18 m1q1sjr4 m1q1sjr4 . cord-307853-m1q1sjr4 5 1 COVID-19 COVID-19 NNP cord-307853-m1q1sjr4 5 2 caused cause VBN cord-307853-m1q1sjr4 5 3 by by IN cord-307853-m1q1sjr4 5 4 SARS SARS NNP cord-307853-m1q1sjr4 5 5 - - HYPH cord-307853-m1q1sjr4 5 6 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 5 7 have have VBP cord-307853-m1q1sjr4 5 8 become become VBN cord-307853-m1q1sjr4 5 9 a a DT cord-307853-m1q1sjr4 5 10 global global JJ cord-307853-m1q1sjr4 5 11 pandemic pandemic NN cord-307853-m1q1sjr4 5 12 with with IN cord-307853-m1q1sjr4 5 13 serious serious JJ cord-307853-m1q1sjr4 5 14 rate rate NN cord-307853-m1q1sjr4 5 15 of of IN cord-307853-m1q1sjr4 5 16 fatalities fatality NNS cord-307853-m1q1sjr4 5 17 . . . cord-307853-m1q1sjr4 6 1 SARS SARS NNP cord-307853-m1q1sjr4 6 2 - - HYPH cord-307853-m1q1sjr4 6 3 CoV CoV NNP cord-307853-m1q1sjr4 6 4 and and CC cord-307853-m1q1sjr4 6 5 MERS MERS NNP cord-307853-m1q1sjr4 6 6 - - HYPH cord-307853-m1q1sjr4 6 7 CoV CoV NNP cord-307853-m1q1sjr4 6 8 have have VBP cord-307853-m1q1sjr4 6 9 also also RB cord-307853-m1q1sjr4 6 10 caused cause VBN cord-307853-m1q1sjr4 6 11 serious serious JJ cord-307853-m1q1sjr4 6 12 outbreak outbreak NN cord-307853-m1q1sjr4 6 13 previously previously RB cord-307853-m1q1sjr4 6 14 but but CC cord-307853-m1q1sjr4 6 15 the the DT cord-307853-m1q1sjr4 6 16 intensity intensity NN cord-307853-m1q1sjr4 6 17 was be VBD cord-307853-m1q1sjr4 6 18 much much RB cord-307853-m1q1sjr4 6 19 lower low JJR cord-307853-m1q1sjr4 6 20 than than IN cord-307853-m1q1sjr4 6 21 the the DT cord-307853-m1q1sjr4 6 22 ongoing ongoing JJ cord-307853-m1q1sjr4 6 23 SARS SARS NNP cord-307853-m1q1sjr4 6 24 - - HYPH cord-307853-m1q1sjr4 6 25 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 6 26 . . . cord-307853-m1q1sjr4 7 1 The the DT cord-307853-m1q1sjr4 7 2 main main JJ cord-307853-m1q1sjr4 7 3 infectivity infectivity NN cord-307853-m1q1sjr4 7 4 factor factor NN cord-307853-m1q1sjr4 7 5 of of IN cord-307853-m1q1sjr4 7 6 all all PDT cord-307853-m1q1sjr4 7 7 the the DT cord-307853-m1q1sjr4 7 8 three three CD cord-307853-m1q1sjr4 7 9 viruses virus NNS cord-307853-m1q1sjr4 7 10 is be VBZ cord-307853-m1q1sjr4 7 11 the the DT cord-307853-m1q1sjr4 7 12 spike spike NN cord-307853-m1q1sjr4 7 13 glycoprotein glycoprotein NN cord-307853-m1q1sjr4 7 14 . . . cord-307853-m1q1sjr4 8 1 In in IN cord-307853-m1q1sjr4 8 2 this this DT cord-307853-m1q1sjr4 8 3 study study NN cord-307853-m1q1sjr4 8 4 we -PRON- PRP cord-307853-m1q1sjr4 8 5 have have VBP cord-307853-m1q1sjr4 8 6 examined examine VBN cord-307853-m1q1sjr4 8 7 the the DT cord-307853-m1q1sjr4 8 8 intrinsic intrinsic JJ cord-307853-m1q1sjr4 8 9 dynamics dynamic NNS cord-307853-m1q1sjr4 8 10 of of IN cord-307853-m1q1sjr4 8 11 the the DT cord-307853-m1q1sjr4 8 12 prefusion prefusion NN cord-307853-m1q1sjr4 8 13 , , , cord-307853-m1q1sjr4 8 14 lying lie VBG cord-307853-m1q1sjr4 8 15 state state NN cord-307853-m1q1sjr4 8 16 of of IN cord-307853-m1q1sjr4 8 17 trimeric trimeric NNP cord-307853-m1q1sjr4 8 18 S S NNP cord-307853-m1q1sjr4 8 19 protein protein NN cord-307853-m1q1sjr4 8 20 of of IN cord-307853-m1q1sjr4 8 21 these these DT cord-307853-m1q1sjr4 8 22 viruses virus NNS cord-307853-m1q1sjr4 8 23 through through IN cord-307853-m1q1sjr4 8 24 Normal Normal NNP cord-307853-m1q1sjr4 8 25 Mode Mode NNP cord-307853-m1q1sjr4 8 26 Analysis Analysis NNP cord-307853-m1q1sjr4 8 27 using use VBG cord-307853-m1q1sjr4 8 28 Anisotropic Anisotropic NNP cord-307853-m1q1sjr4 8 29 Network Network NNP cord-307853-m1q1sjr4 8 30 Model Model NNP cord-307853-m1q1sjr4 8 31 . . . cord-307853-m1q1sjr4 9 1 The the DT cord-307853-m1q1sjr4 9 2 dynamic dynamic JJ cord-307853-m1q1sjr4 9 3 modes mode NNS cord-307853-m1q1sjr4 9 4 of of IN cord-307853-m1q1sjr4 9 5 the the DT cord-307853-m1q1sjr4 9 6 S S NNP cord-307853-m1q1sjr4 9 7 proteins protein NNS cord-307853-m1q1sjr4 9 8 of of IN cord-307853-m1q1sjr4 9 9 the the DT cord-307853-m1q1sjr4 9 10 aforementioned aforementioned JJ cord-307853-m1q1sjr4 9 11 viruses virus NNS cord-307853-m1q1sjr4 9 12 were be VBD cord-307853-m1q1sjr4 9 13 compared compare VBN cord-307853-m1q1sjr4 9 14 by by IN cord-307853-m1q1sjr4 9 15 root root NN cord-307853-m1q1sjr4 9 16 mean mean VBP cord-307853-m1q1sjr4 9 17 square square JJ cord-307853-m1q1sjr4 9 18 inner inner JJ cord-307853-m1q1sjr4 9 19 product product NN cord-307853-m1q1sjr4 9 20 ( ( -LRB- cord-307853-m1q1sjr4 9 21 RMSIP RMSIP NNP cord-307853-m1q1sjr4 9 22 ) ) -RRB- cord-307853-m1q1sjr4 9 23 , , , cord-307853-m1q1sjr4 9 24 spectral spectral JJ cord-307853-m1q1sjr4 9 25 overlap overlap NN cord-307853-m1q1sjr4 9 26 and and CC cord-307853-m1q1sjr4 9 27 cosine cosine NN cord-307853-m1q1sjr4 9 28 correlation correlation NN cord-307853-m1q1sjr4 9 29 matrix matrix NN cord-307853-m1q1sjr4 9 30 . . . cord-307853-m1q1sjr4 10 1 S s NN cord-307853-m1q1sjr4 10 2 proteins protein NNS cord-307853-m1q1sjr4 10 3 show show VBP cord-307853-m1q1sjr4 10 4 homogenous homogenous JJ cord-307853-m1q1sjr4 10 5 correlated correlate VBD cord-307853-m1q1sjr4 10 6 or or CC cord-307853-m1q1sjr4 10 7 anticorrelated anticorrelated JJ cord-307853-m1q1sjr4 10 8 motions motion NNS cord-307853-m1q1sjr4 10 9 among among IN cord-307853-m1q1sjr4 10 10 their -PRON- PRP$ cord-307853-m1q1sjr4 10 11 domains domain NNS cord-307853-m1q1sjr4 10 12 but but CC cord-307853-m1q1sjr4 10 13 direction direction NN cord-307853-m1q1sjr4 10 14 of of IN cord-307853-m1q1sjr4 10 15 C(α C(α NNP cord-307853-m1q1sjr4 10 16 ) ) -RRB- cord-307853-m1q1sjr4 10 17 atom atom NN cord-307853-m1q1sjr4 10 18 among among IN cord-307853-m1q1sjr4 10 19 the the DT cord-307853-m1q1sjr4 10 20 spike spike NN cord-307853-m1q1sjr4 10 21 proteins protein NNS cord-307853-m1q1sjr4 10 22 show show VBP cord-307853-m1q1sjr4 10 23 less less JJR cord-307853-m1q1sjr4 10 24 similarity similarity NN cord-307853-m1q1sjr4 10 25 . . . cord-307853-m1q1sjr4 11 1 SARS SARS NNP cord-307853-m1q1sjr4 11 2 - - HYPH cord-307853-m1q1sjr4 11 3 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 11 4 spike spike NN cord-307853-m1q1sjr4 11 5 shows show VBZ cord-307853-m1q1sjr4 11 6 high high RB cord-307853-m1q1sjr4 11 7 vertically vertically RB cord-307853-m1q1sjr4 11 8 upward upward JJ cord-307853-m1q1sjr4 11 9 motion motion NN cord-307853-m1q1sjr4 11 10 of of IN cord-307853-m1q1sjr4 11 11 the the DT cord-307853-m1q1sjr4 11 12 receptor receptor NN cord-307853-m1q1sjr4 11 13 binding bind VBG cord-307853-m1q1sjr4 11 14 motif motif NN cord-307853-m1q1sjr4 11 15 implying imply VBG cord-307853-m1q1sjr4 11 16 its -PRON- PRP$ cord-307853-m1q1sjr4 11 17 propensity propensity NN cord-307853-m1q1sjr4 11 18 for for IN cord-307853-m1q1sjr4 11 19 binding bind VBG cord-307853-m1q1sjr4 11 20 with with IN cord-307853-m1q1sjr4 11 21 the the DT cord-307853-m1q1sjr4 11 22 receptor receptor NN cord-307853-m1q1sjr4 11 23 even even RB cord-307853-m1q1sjr4 11 24 in in IN cord-307853-m1q1sjr4 11 25 the the DT cord-307853-m1q1sjr4 11 26 lying lie VBG cord-307853-m1q1sjr4 11 27 state state NN cord-307853-m1q1sjr4 11 28 . . . cord-307853-m1q1sjr4 12 1 MERS MERS NNP cord-307853-m1q1sjr4 12 2 - - HYPH cord-307853-m1q1sjr4 12 3 CoV cov NN cord-307853-m1q1sjr4 12 4 spike spike NN cord-307853-m1q1sjr4 12 5 shows show VBZ cord-307853-m1q1sjr4 12 6 unique unique JJ cord-307853-m1q1sjr4 12 7 dynamical dynamical JJ cord-307853-m1q1sjr4 12 8 motion motion NN cord-307853-m1q1sjr4 12 9 compared compare VBN cord-307853-m1q1sjr4 12 10 to to IN cord-307853-m1q1sjr4 12 11 the the DT cord-307853-m1q1sjr4 12 12 other other JJ cord-307853-m1q1sjr4 12 13 two two CD cord-307853-m1q1sjr4 12 14 S S NNP cord-307853-m1q1sjr4 12 15 protein protein NN cord-307853-m1q1sjr4 12 16 indicated indicate VBN cord-307853-m1q1sjr4 12 17 by by IN cord-307853-m1q1sjr4 12 18 low low JJ cord-307853-m1q1sjr4 12 19 RMSIP RMSIP NNP cord-307853-m1q1sjr4 12 20 , , , cord-307853-m1q1sjr4 12 21 spectral spectral JJ cord-307853-m1q1sjr4 12 22 overlap overlap NN cord-307853-m1q1sjr4 12 23 and and CC cord-307853-m1q1sjr4 12 24 cosine cosine NN cord-307853-m1q1sjr4 12 25 correlation correlation NN cord-307853-m1q1sjr4 12 26 value value NN cord-307853-m1q1sjr4 12 27 . . . cord-307853-m1q1sjr4 13 1 This this DT cord-307853-m1q1sjr4 13 2 study study NN cord-307853-m1q1sjr4 13 3 will will MD cord-307853-m1q1sjr4 13 4 guide guide VB cord-307853-m1q1sjr4 13 5 in in IN cord-307853-m1q1sjr4 13 6 developing develop VBG cord-307853-m1q1sjr4 13 7 common common JJ cord-307853-m1q1sjr4 13 8 potential potential JJ cord-307853-m1q1sjr4 13 9 inhibitor inhibitor NN cord-307853-m1q1sjr4 13 10 molecules molecule NNS cord-307853-m1q1sjr4 13 11 against against IN cord-307853-m1q1sjr4 13 12 closed closed JJ cord-307853-m1q1sjr4 13 13 state state NN cord-307853-m1q1sjr4 13 14 of of IN cord-307853-m1q1sjr4 13 15 spike spike NN cord-307853-m1q1sjr4 13 16 protein protein NN cord-307853-m1q1sjr4 13 17 of of IN cord-307853-m1q1sjr4 13 18 these these DT cord-307853-m1q1sjr4 13 19 viruses virus NNS cord-307853-m1q1sjr4 13 20 to to TO cord-307853-m1q1sjr4 13 21 prevent prevent VB cord-307853-m1q1sjr4 13 22 conformational conformational JJ cord-307853-m1q1sjr4 13 23 switching switching NN cord-307853-m1q1sjr4 13 24 from from IN cord-307853-m1q1sjr4 13 25 lying lie VBG cord-307853-m1q1sjr4 13 26 to to IN cord-307853-m1q1sjr4 13 27 standing stand VBG cord-307853-m1q1sjr4 13 28 state state NN cord-307853-m1q1sjr4 13 29 . . . cord-307853-m1q1sjr4 14 1 Coronaviruses coronaviruse NNS cord-307853-m1q1sjr4 14 2 are be VBP cord-307853-m1q1sjr4 14 3 zoonotic zoonotic JJ cord-307853-m1q1sjr4 14 4 pathogens pathogen NNS cord-307853-m1q1sjr4 14 5 which which WDT cord-307853-m1q1sjr4 14 6 belong belong VBP cord-307853-m1q1sjr4 14 7 to to IN cord-307853-m1q1sjr4 14 8 the the DT cord-307853-m1q1sjr4 14 9 largest large JJS cord-307853-m1q1sjr4 14 10 group group NN cord-307853-m1q1sjr4 14 11 of of IN cord-307853-m1q1sjr4 14 12 Nidovirales Nidovirales NNP cord-307853-m1q1sjr4 14 13 order order NN cord-307853-m1q1sjr4 14 14 [ [ -LRB- cord-307853-m1q1sjr4 14 15 1 1 CD cord-307853-m1q1sjr4 14 16 ] ] -RRB- cord-307853-m1q1sjr4 14 17 and and CC cord-307853-m1q1sjr4 14 18 has have VBZ cord-307853-m1q1sjr4 14 19 been be VBN cord-307853-m1q1sjr4 14 20 shown show VBN cord-307853-m1q1sjr4 14 21 to to TO cord-307853-m1q1sjr4 14 22 infect infect VB cord-307853-m1q1sjr4 14 23 many many JJ cord-307853-m1q1sjr4 14 24 avian avian JJ cord-307853-m1q1sjr4 14 25 and and CC cord-307853-m1q1sjr4 14 26 mammalian mammalian JJ cord-307853-m1q1sjr4 14 27 species specie NNS cord-307853-m1q1sjr4 14 28 [ [ -LRB- cord-307853-m1q1sjr4 14 29 2 2 CD cord-307853-m1q1sjr4 14 30 ] ] -RRB- cord-307853-m1q1sjr4 14 31 . . . cord-307853-m1q1sjr4 15 1 Severe severe JJ cord-307853-m1q1sjr4 15 2 acute acute JJ cord-307853-m1q1sjr4 15 3 respiratory respiratory JJ cord-307853-m1q1sjr4 15 4 syndrome syndrome NN cord-307853-m1q1sjr4 15 5 coronavirus coronavirus NN cord-307853-m1q1sjr4 15 6 ( ( -LRB- cord-307853-m1q1sjr4 15 7 SARS SARS NNP cord-307853-m1q1sjr4 15 8 - - HYPH cord-307853-m1q1sjr4 15 9 CoV CoV NNP cord-307853-m1q1sjr4 15 10 ) ) -RRB- cord-307853-m1q1sjr4 15 11 , , , cord-307853-m1q1sjr4 15 12 Middle Middle NNP cord-307853-m1q1sjr4 15 13 East East NNP cord-307853-m1q1sjr4 15 14 respiratory respiratory JJ cord-307853-m1q1sjr4 15 15 syndrome syndrome NN cord-307853-m1q1sjr4 15 16 coronavirus coronavirus NN cord-307853-m1q1sjr4 15 17 ( ( -LRB- cord-307853-m1q1sjr4 15 18 MERS MERS NNP cord-307853-m1q1sjr4 15 19 - - HYPH cord-307853-m1q1sjr4 15 20 CoV CoV NNP cord-307853-m1q1sjr4 15 21 ) ) -RRB- cord-307853-m1q1sjr4 15 22 and and CC cord-307853-m1q1sjr4 15 23 novel novel JJ cord-307853-m1q1sjr4 15 24 coronavirus coronavirus NN cord-307853-m1q1sjr4 15 25 ( ( -LRB- cord-307853-m1q1sjr4 15 26 SARS SARS NNP cord-307853-m1q1sjr4 15 27 - - HYPH cord-307853-m1q1sjr4 15 28 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 15 29 ) ) -RRB- cord-307853-m1q1sjr4 15 30 are be VBP cord-307853-m1q1sjr4 15 31 in in IN cord-307853-m1q1sjr4 15 32 betacoronavirus betacoronavirus NN cord-307853-m1q1sjr4 15 33 family family NN cord-307853-m1q1sjr4 15 34 but but CC cord-307853-m1q1sjr4 15 35 with with IN cord-307853-m1q1sjr4 15 36 different different JJ cord-307853-m1q1sjr4 15 37 lineages lineage NNS cord-307853-m1q1sjr4 15 38 . . . cord-307853-m1q1sjr4 16 1 SARS SARS NNP cord-307853-m1q1sjr4 16 2 - - HYPH cord-307853-m1q1sjr4 16 3 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 16 4 , , , cord-307853-m1q1sjr4 16 5 SARS SARS NNP cord-307853-m1q1sjr4 16 6 - - HYPH cord-307853-m1q1sjr4 16 7 CoV CoV NNP cord-307853-m1q1sjr4 16 8 belongs belong VBZ cord-307853-m1q1sjr4 16 9 to to IN cord-307853-m1q1sjr4 16 10 lineage lineage NN cord-307853-m1q1sjr4 16 11 B b NN cord-307853-m1q1sjr4 16 12 whereas whereas IN cord-307853-m1q1sjr4 16 13 MERS MERS NNP cord-307853-m1q1sjr4 16 14 - - HYPH cord-307853-m1q1sjr4 16 15 CoV CoV NNP cord-307853-m1q1sjr4 16 16 belongs belong VBZ cord-307853-m1q1sjr4 16 17 to to IN cord-307853-m1q1sjr4 16 18 lineage lineage NN cord-307853-m1q1sjr4 16 19 C c NN cord-307853-m1q1sjr4 16 20 but but CC cord-307853-m1q1sjr4 16 21 a a DT cord-307853-m1q1sjr4 16 22 common common JJ cord-307853-m1q1sjr4 16 23 factor factor NN cord-307853-m1q1sjr4 17 1 is be VBZ cord-307853-m1q1sjr4 17 2 that that IN cord-307853-m1q1sjr4 17 3 they -PRON- PRP cord-307853-m1q1sjr4 17 4 all all DT cord-307853-m1q1sjr4 17 5 cause cause VBP cord-307853-m1q1sjr4 17 6 acute acute JJ cord-307853-m1q1sjr4 17 7 lung lung NN cord-307853-m1q1sjr4 17 8 injury injury NN cord-307853-m1q1sjr4 17 9 ( ( -LRB- cord-307853-m1q1sjr4 17 10 ALI ALI NNP cord-307853-m1q1sjr4 17 11 ) ) -RRB- cord-307853-m1q1sjr4 17 12 and and CC cord-307853-m1q1sjr4 17 13 acute acute JJ cord-307853-m1q1sjr4 17 14 respiratory respiratory JJ cord-307853-m1q1sjr4 17 15 distress distress NN cord-307853-m1q1sjr4 17 16 syndrome syndrome NN cord-307853-m1q1sjr4 17 17 ( ( -LRB- cord-307853-m1q1sjr4 17 18 ARDS ARDS NNP cord-307853-m1q1sjr4 17 19 ) ) -RRB- cord-307853-m1q1sjr4 17 20 which which WDT cord-307853-m1q1sjr4 17 21 leads lead VBZ cord-307853-m1q1sjr4 17 22 to to IN cord-307853-m1q1sjr4 17 23 pulmonary pulmonary JJ cord-307853-m1q1sjr4 17 24 failure failure NN cord-307853-m1q1sjr4 17 25 and and CC cord-307853-m1q1sjr4 17 26 result result VB cord-307853-m1q1sjr4 17 27 in in IN cord-307853-m1q1sjr4 17 28 fatality fatality NN cord-307853-m1q1sjr4 17 29 . . . cord-307853-m1q1sjr4 18 1 COVID-19 COVID-19 NNP cord-307853-m1q1sjr4 18 2 caused cause VBN cord-307853-m1q1sjr4 18 3 by by IN cord-307853-m1q1sjr4 18 4 novel novel JJ cord-307853-m1q1sjr4 18 5 coronavirus coronavirus NN cord-307853-m1q1sjr4 18 6 ( ( -LRB- cord-307853-m1q1sjr4 18 7 SARS SARS NNP cord-307853-m1q1sjr4 18 8 - - HYPH cord-307853-m1q1sjr4 18 9 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 18 10 ) ) -RRB- cord-307853-m1q1sjr4 18 11 , , , cord-307853-m1q1sjr4 18 12 has have VBZ cord-307853-m1q1sjr4 18 13 now now RB cord-307853-m1q1sjr4 18 14 emerged emerge VBN cord-307853-m1q1sjr4 18 15 as as IN cord-307853-m1q1sjr4 18 16 global global JJ cord-307853-m1q1sjr4 18 17 pandemic pandemic NN cord-307853-m1q1sjr4 18 18 and and CC cord-307853-m1q1sjr4 18 19 high high JJ cord-307853-m1q1sjr4 18 20 rate rate NN cord-307853-m1q1sjr4 18 21 of of IN cord-307853-m1q1sjr4 18 22 fatalities fatality NNS cord-307853-m1q1sjr4 18 23 have have VBP cord-307853-m1q1sjr4 18 24 been be VBN cord-307853-m1q1sjr4 18 25 reported report VBN cord-307853-m1q1sjr4 18 26 globally globally RB cord-307853-m1q1sjr4 18 27 [ [ -LRB- cord-307853-m1q1sjr4 18 28 3 3 CD cord-307853-m1q1sjr4 18 29 , , , cord-307853-m1q1sjr4 18 30 4 4 CD cord-307853-m1q1sjr4 18 31 , , , cord-307853-m1q1sjr4 18 32 5 5 CD cord-307853-m1q1sjr4 18 33 ] ] -RRB- cord-307853-m1q1sjr4 18 34 . . . cord-307853-m1q1sjr4 19 1 The the DT cord-307853-m1q1sjr4 19 2 major major JJ cord-307853-m1q1sjr4 19 3 surface surface NN cord-307853-m1q1sjr4 19 4 protein protein NN cord-307853-m1q1sjr4 19 5 of of IN cord-307853-m1q1sjr4 19 6 all all PDT cord-307853-m1q1sjr4 19 7 these these DT cord-307853-m1q1sjr4 19 8 3 3 CD cord-307853-m1q1sjr4 19 9 coronaviruses coronaviruse NNS cord-307853-m1q1sjr4 19 10 is be VBZ cord-307853-m1q1sjr4 19 11 called call VBN cord-307853-m1q1sjr4 19 12 spike spike NN cord-307853-m1q1sjr4 19 13 glycoprotein glycoprotein NN cord-307853-m1q1sjr4 19 14 ( ( -LRB- cord-307853-m1q1sjr4 19 15 S s NN cord-307853-m1q1sjr4 19 16 ) ) -RRB- cord-307853-m1q1sjr4 19 17 which which WDT cord-307853-m1q1sjr4 19 18 is be VBZ cord-307853-m1q1sjr4 19 19 responsible responsible JJ cord-307853-m1q1sjr4 19 20 for for IN cord-307853-m1q1sjr4 19 21 host host NN cord-307853-m1q1sjr4 19 22 attachment attachment NN cord-307853-m1q1sjr4 19 23 of of IN cord-307853-m1q1sjr4 19 24 the the DT cord-307853-m1q1sjr4 19 25 virus virus NN cord-307853-m1q1sjr4 19 26 and and CC cord-307853-m1q1sjr4 19 27 entry entry NN cord-307853-m1q1sjr4 19 28 into into IN cord-307853-m1q1sjr4 19 29 cell cell NN cord-307853-m1q1sjr4 19 30 by by IN cord-307853-m1q1sjr4 19 31 membrane membrane NN cord-307853-m1q1sjr4 19 32 fusion fusion NN cord-307853-m1q1sjr4 19 33 . . . cord-307853-m1q1sjr4 20 1 The the DT cord-307853-m1q1sjr4 20 2 protein protein NN cord-307853-m1q1sjr4 20 3 protrudes protrude VBZ cord-307853-m1q1sjr4 20 4 out out IN cord-307853-m1q1sjr4 20 5 of of IN cord-307853-m1q1sjr4 20 6 the the DT cord-307853-m1q1sjr4 20 7 surface surface NN cord-307853-m1q1sjr4 20 8 and and CC cord-307853-m1q1sjr4 20 9 is be VBZ cord-307853-m1q1sjr4 20 10 found find VBN cord-307853-m1q1sjr4 20 11 in in IN cord-307853-m1q1sjr4 20 12 a a DT cord-307853-m1q1sjr4 20 13 trimeric trimeric JJ cord-307853-m1q1sjr4 20 14 configuration configuration NN cord-307853-m1q1sjr4 20 15 [ [ -LRB- cord-307853-m1q1sjr4 20 16 6 6 CD cord-307853-m1q1sjr4 20 17 ] ] -RRB- cord-307853-m1q1sjr4 20 18 . . . cord-307853-m1q1sjr4 21 1 The the DT cord-307853-m1q1sjr4 21 2 protein protein NN cord-307853-m1q1sjr4 21 3 has have VBZ cord-307853-m1q1sjr4 21 4 2 2 CD cord-307853-m1q1sjr4 21 5 subunits subunit NNS cord-307853-m1q1sjr4 21 6 called call VBN cord-307853-m1q1sjr4 21 7 S1 S1 NNP cord-307853-m1q1sjr4 21 8 and and CC cord-307853-m1q1sjr4 21 9 S2 S2 NNP cord-307853-m1q1sjr4 21 10 . . . cord-307853-m1q1sjr4 22 1 S1 s1 NN cord-307853-m1q1sjr4 22 2 subunit subunit NN cord-307853-m1q1sjr4 22 3 has have VBZ cord-307853-m1q1sjr4 22 4 the the DT cord-307853-m1q1sjr4 22 5 receptor receptor NN cord-307853-m1q1sjr4 22 6 binding bind VBG cord-307853-m1q1sjr4 22 7 domains domain NNS cord-307853-m1q1sjr4 22 8 ( ( -LRB- cord-307853-m1q1sjr4 22 9 RBD RBD NNP cord-307853-m1q1sjr4 22 10 ) ) -RRB- cord-307853-m1q1sjr4 22 11 which which WDT cord-307853-m1q1sjr4 22 12 help help VBP cord-307853-m1q1sjr4 22 13 to to TO cord-307853-m1q1sjr4 22 14 stabilize stabilize VB cord-307853-m1q1sjr4 22 15 the the DT cord-307853-m1q1sjr4 22 16 prefusion prefusion NN cord-307853-m1q1sjr4 22 17 state state NN cord-307853-m1q1sjr4 22 18 . . . cord-307853-m1q1sjr4 23 1 The the DT cord-307853-m1q1sjr4 23 2 S2 S2 NNP cord-307853-m1q1sjr4 23 3 subunit subunit NN cord-307853-m1q1sjr4 23 4 remains remain VBZ cord-307853-m1q1sjr4 23 5 anchored anchor VBN cord-307853-m1q1sjr4 23 6 to to IN cord-307853-m1q1sjr4 23 7 the the DT cord-307853-m1q1sjr4 23 8 membrane membrane NN cord-307853-m1q1sjr4 23 9 and and CC cord-307853-m1q1sjr4 23 10 contains contain VBZ cord-307853-m1q1sjr4 23 11 the the DT cord-307853-m1q1sjr4 23 12 fusion fusion NN cord-307853-m1q1sjr4 23 13 machinery machinery NN cord-307853-m1q1sjr4 23 14 and and CC cord-307853-m1q1sjr4 23 15 further further RB cord-307853-m1q1sjr4 23 16 cleaved cleave VBN cord-307853-m1q1sjr4 23 17 to to TO cord-307853-m1q1sjr4 23 18 form form VB cord-307853-m1q1sjr4 23 19 S2 S2 NNP cord-307853-m1q1sjr4 23 20 ' ' '' cord-307853-m1q1sjr4 23 21 in in IN cord-307853-m1q1sjr4 23 22 certain certain JJ cord-307853-m1q1sjr4 23 23 coronaviruses coronaviruse NNS cord-307853-m1q1sjr4 23 24 thus thus RB cord-307853-m1q1sjr4 23 25 activating activate VBG cord-307853-m1q1sjr4 23 26 the the DT cord-307853-m1q1sjr4 23 27 membrane membrane NN cord-307853-m1q1sjr4 23 28 fusion fusion NN cord-307853-m1q1sjr4 23 29 cascade cascade NN cord-307853-m1q1sjr4 23 30 [ [ -LRB- cord-307853-m1q1sjr4 23 31 7 7 CD cord-307853-m1q1sjr4 23 32 , , , cord-307853-m1q1sjr4 23 33 8 8 CD cord-307853-m1q1sjr4 23 34 ] ] -RRB- cord-307853-m1q1sjr4 23 35 . . . cord-307853-m1q1sjr4 24 1 The the DT cord-307853-m1q1sjr4 24 2 receptors receptor NNS cord-307853-m1q1sjr4 24 3 recognized recognize VBN cord-307853-m1q1sjr4 24 4 by by IN cord-307853-m1q1sjr4 24 5 the the DT cord-307853-m1q1sjr4 24 6 viruses virus NNS cord-307853-m1q1sjr4 24 7 are be VBP cord-307853-m1q1sjr4 24 8 also also RB cord-307853-m1q1sjr4 24 9 different different JJ cord-307853-m1q1sjr4 24 10 in in IN cord-307853-m1q1sjr4 24 11 case case NN cord-307853-m1q1sjr4 24 12 of of IN cord-307853-m1q1sjr4 24 13 MERS MERS NNP cord-307853-m1q1sjr4 24 14 - - HYPH cord-307853-m1q1sjr4 24 15 CoV CoV NNP cord-307853-m1q1sjr4 25 1 it -PRON- PRP cord-307853-m1q1sjr4 25 2 is be VBZ cord-307853-m1q1sjr4 25 3 5-N 5-n CD cord-307853-m1q1sjr4 25 4 - - HYPH cord-307853-m1q1sjr4 25 5 acetyl-9-O acetyl-9-o NN cord-307853-m1q1sjr4 25 6 - - HYPH cord-307853-m1q1sjr4 25 7 acetyl acetyl NN cord-307853-m1q1sjr4 25 8 - - HYPH cord-307853-m1q1sjr4 25 9 sialosides sialoside NNS cord-307853-m1q1sjr4 25 10 found find VBN cord-307853-m1q1sjr4 25 11 on on IN cord-307853-m1q1sjr4 25 12 glycoproteins glycoprotein NNS cord-307853-m1q1sjr4 25 13 and and CC cord-307853-m1q1sjr4 25 14 glyco glyco NNS cord-307853-m1q1sjr4 25 15 - - HYPH cord-307853-m1q1sjr4 25 16 lipids lipid NNS cord-307853-m1q1sjr4 25 17 at at IN cord-307853-m1q1sjr4 25 18 the the DT cord-307853-m1q1sjr4 25 19 host host NN cord-307853-m1q1sjr4 25 20 cell cell NN cord-307853-m1q1sjr4 25 21 surface surface NN cord-307853-m1q1sjr4 25 22 while while IN cord-307853-m1q1sjr4 25 23 for for IN cord-307853-m1q1sjr4 25 24 SARS SARS NNP cord-307853-m1q1sjr4 25 25 - - HYPH cord-307853-m1q1sjr4 25 26 CoV CoV NNP cord-307853-m1q1sjr4 25 27 and and CC cord-307853-m1q1sjr4 25 28 SARS SARS NNP cord-307853-m1q1sjr4 25 29 - - : cord-307853-m1q1sjr4 25 30 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 25 31 it -PRON- PRP cord-307853-m1q1sjr4 25 32 is be VBZ cord-307853-m1q1sjr4 25 33 hACE2 hace2 ADD cord-307853-m1q1sjr4 25 34 receptor receptor NN cord-307853-m1q1sjr4 25 35 [ [ -LRB- cord-307853-m1q1sjr4 25 36 9 9 CD cord-307853-m1q1sjr4 25 37 , , , cord-307853-m1q1sjr4 25 38 10 10 CD cord-307853-m1q1sjr4 25 39 ] ] -RRB- cord-307853-m1q1sjr4 25 40 . . . cord-307853-m1q1sjr4 26 1 Spike spike NN cord-307853-m1q1sjr4 26 2 glycoprotein glycoprotein NN cord-307853-m1q1sjr4 26 3 undergoes undergo VBZ cord-307853-m1q1sjr4 26 4 conformational conformational JJ cord-307853-m1q1sjr4 26 5 switch switch NN cord-307853-m1q1sjr4 26 6 in in IN cord-307853-m1q1sjr4 26 7 order order NN cord-307853-m1q1sjr4 26 8 to to TO cord-307853-m1q1sjr4 26 9 bind bind VB cord-307853-m1q1sjr4 26 10 with with IN cord-307853-m1q1sjr4 26 11 the the DT cord-307853-m1q1sjr4 26 12 receptor receptor NN cord-307853-m1q1sjr4 26 13 . . . cord-307853-m1q1sjr4 27 1 In in IN cord-307853-m1q1sjr4 27 2 lying lie VBG cord-307853-m1q1sjr4 27 3 or or CC cord-307853-m1q1sjr4 27 4 closed closed JJ cord-307853-m1q1sjr4 27 5 state state NN cord-307853-m1q1sjr4 27 6 the the DT cord-307853-m1q1sjr4 27 7 receptor receptor NN cord-307853-m1q1sjr4 27 8 binding bind VBG cord-307853-m1q1sjr4 27 9 domain domain NN cord-307853-m1q1sjr4 27 10 is be VBZ cord-307853-m1q1sjr4 27 11 buried bury VBN cord-307853-m1q1sjr4 27 12 deeply deeply RB cord-307853-m1q1sjr4 27 13 into into IN cord-307853-m1q1sjr4 27 14 the the DT cord-307853-m1q1sjr4 27 15 trimer trimer NN cord-307853-m1q1sjr4 27 16 core core NN cord-307853-m1q1sjr4 28 1 and and CC cord-307853-m1q1sjr4 28 2 so so RB cord-307853-m1q1sjr4 28 3 it -PRON- PRP cord-307853-m1q1sjr4 28 4 is be VBZ cord-307853-m1q1sjr4 28 5 not not RB cord-307853-m1q1sjr4 28 6 accessible accessible JJ cord-307853-m1q1sjr4 28 7 to to IN cord-307853-m1q1sjr4 28 8 the the DT cord-307853-m1q1sjr4 28 9 receptor receptor NN cord-307853-m1q1sjr4 28 10 making make VBG cord-307853-m1q1sjr4 28 11 the the DT cord-307853-m1q1sjr4 28 12 conformational conformational JJ cord-307853-m1q1sjr4 28 13 switch switch NN cord-307853-m1q1sjr4 28 14 essential essential JJ cord-307853-m1q1sjr4 28 15 . . . cord-307853-m1q1sjr4 29 1 In in IN cord-307853-m1q1sjr4 29 2 standing stand VBG cord-307853-m1q1sjr4 29 3 or or CC cord-307853-m1q1sjr4 29 4 open open JJ cord-307853-m1q1sjr4 29 5 state state NN cord-307853-m1q1sjr4 29 6 one one CD cord-307853-m1q1sjr4 29 7 of of IN cord-307853-m1q1sjr4 29 8 the the DT cord-307853-m1q1sjr4 29 9 RBD RBD NNP cord-307853-m1q1sjr4 29 10 protrudes protrude VBZ cord-307853-m1q1sjr4 29 11 out out IN cord-307853-m1q1sjr4 29 12 of of IN cord-307853-m1q1sjr4 29 13 the the DT cord-307853-m1q1sjr4 29 14 trimer trimer NN cord-307853-m1q1sjr4 29 15 core core NN cord-307853-m1q1sjr4 29 16 and and CC cord-307853-m1q1sjr4 29 17 becomes become VBZ cord-307853-m1q1sjr4 29 18 accessible accessible JJ cord-307853-m1q1sjr4 29 19 to to IN cord-307853-m1q1sjr4 29 20 the the DT cord-307853-m1q1sjr4 29 21 receptor receptor NN cord-307853-m1q1sjr4 29 22 [ [ -LRB- cord-307853-m1q1sjr4 29 23 11 11 CD cord-307853-m1q1sjr4 29 24 ] ] -RRB- cord-307853-m1q1sjr4 29 25 . . . cord-307853-m1q1sjr4 30 1 A a DT cord-307853-m1q1sjr4 30 2 detailed detailed JJ cord-307853-m1q1sjr4 30 3 study study NN cord-307853-m1q1sjr4 30 4 to to TO cord-307853-m1q1sjr4 30 5 explore explore VB cord-307853-m1q1sjr4 30 6 the the DT cord-307853-m1q1sjr4 30 7 intrinsic intrinsic JJ cord-307853-m1q1sjr4 30 8 dynamical dynamical JJ cord-307853-m1q1sjr4 30 9 motion motion NN cord-307853-m1q1sjr4 30 10 of of IN cord-307853-m1q1sjr4 30 11 the the DT cord-307853-m1q1sjr4 30 12 prefusion prefusion NN cord-307853-m1q1sjr4 30 13 lying lie VBG cord-307853-m1q1sjr4 30 14 state state NN cord-307853-m1q1sjr4 30 15 spike spike NN cord-307853-m1q1sjr4 30 16 protein protein NN cord-307853-m1q1sjr4 30 17 trimer trimer NN cord-307853-m1q1sjr4 30 18 is be VBZ cord-307853-m1q1sjr4 30 19 needed need VBN cord-307853-m1q1sjr4 30 20 for for IN cord-307853-m1q1sjr4 30 21 proper proper JJ cord-307853-m1q1sjr4 30 22 understanding understanding NN cord-307853-m1q1sjr4 30 23 of of IN cord-307853-m1q1sjr4 30 24 its -PRON- PRP$ cord-307853-m1q1sjr4 30 25 function function NN cord-307853-m1q1sjr4 30 26 from from IN cord-307853-m1q1sjr4 30 27 conformation conformation NN cord-307853-m1q1sjr4 30 28 perspective perspective NN cord-307853-m1q1sjr4 30 29 . . . cord-307853-m1q1sjr4 31 1 In in IN cord-307853-m1q1sjr4 31 2 recent recent JJ cord-307853-m1q1sjr4 31 3 years year NNS cord-307853-m1q1sjr4 31 4 characterization characterization NN cord-307853-m1q1sjr4 31 5 of of IN cord-307853-m1q1sjr4 31 6 whole whole JJ cord-307853-m1q1sjr4 31 7 protein protein NN cord-307853-m1q1sjr4 31 8 collective collective NN cord-307853-m1q1sjr4 31 9 and and CC cord-307853-m1q1sjr4 31 10 domain domain NN cord-307853-m1q1sjr4 31 11 - - HYPH cord-307853-m1q1sjr4 31 12 specific specific JJ cord-307853-m1q1sjr4 31 13 motions motion NNS cord-307853-m1q1sjr4 31 14 have have VBP cord-307853-m1q1sjr4 31 15 been be VBN cord-307853-m1q1sjr4 31 16 accomplished accomplish VBN cord-307853-m1q1sjr4 31 17 using use VBG cord-307853-m1q1sjr4 31 18 normal normal JJ cord-307853-m1q1sjr4 31 19 mode mode NN cord-307853-m1q1sjr4 31 20 calculations calculation NNS cord-307853-m1q1sjr4 31 21 [ [ -LRB- cord-307853-m1q1sjr4 31 22 12 12 CD cord-307853-m1q1sjr4 31 23 , , , cord-307853-m1q1sjr4 31 24 13 13 CD cord-307853-m1q1sjr4 31 25 ] ] -RRB- cord-307853-m1q1sjr4 31 26 . . . cord-307853-m1q1sjr4 32 1 Coarse coarse JJ cord-307853-m1q1sjr4 32 2 - - HYPH cord-307853-m1q1sjr4 32 3 grained grained JJ cord-307853-m1q1sjr4 32 4 normal normal JJ cord-307853-m1q1sjr4 32 5 mode mode NN cord-307853-m1q1sjr4 32 6 analysis analysis NN cord-307853-m1q1sjr4 33 1 ( ( -LRB- cord-307853-m1q1sjr4 33 2 CG CG NNP cord-307853-m1q1sjr4 33 3 - - HYPH cord-307853-m1q1sjr4 33 4 NMA NMA NNP cord-307853-m1q1sjr4 33 5 ) ) -RRB- cord-307853-m1q1sjr4 33 6 has have VBZ cord-307853-m1q1sjr4 33 7 now now RB cord-307853-m1q1sjr4 33 8 become become VBN cord-307853-m1q1sjr4 33 9 a a DT cord-307853-m1q1sjr4 33 10 valuable valuable JJ cord-307853-m1q1sjr4 33 11 tool tool NN cord-307853-m1q1sjr4 33 12 for for IN cord-307853-m1q1sjr4 33 13 studying study VBG cord-307853-m1q1sjr4 33 14 the the DT cord-307853-m1q1sjr4 33 15 biologically biologically RB cord-307853-m1q1sjr4 33 16 relevant relevant JJ cord-307853-m1q1sjr4 33 17 conformational conformational JJ cord-307853-m1q1sjr4 33 18 motions motion NNS cord-307853-m1q1sjr4 33 19 of of IN cord-307853-m1q1sjr4 33 20 large large JJ cord-307853-m1q1sjr4 33 21 protein protein NN cord-307853-m1q1sjr4 33 22 or or CC cord-307853-m1q1sjr4 33 23 protein protein NN cord-307853-m1q1sjr4 33 24 complex complex NN cord-307853-m1q1sjr4 33 25 . . . cord-307853-m1q1sjr4 34 1 Although although IN cord-307853-m1q1sjr4 34 2 coarse coarse RB cord-307853-m1q1sjr4 34 3 - - HYPH cord-307853-m1q1sjr4 34 4 grained grained JJ cord-307853-m1q1sjr4 34 5 NMA NMA NNP cord-307853-m1q1sjr4 34 6 ( ( -LRB- cord-307853-m1q1sjr4 34 7 CG CG NNP cord-307853-m1q1sjr4 34 8 - - HYPH cord-307853-m1q1sjr4 34 9 NMA NMA NNP cord-307853-m1q1sjr4 34 10 ) ) -RRB- cord-307853-m1q1sjr4 34 11 does do VBZ cord-307853-m1q1sjr4 34 12 not not RB cord-307853-m1q1sjr4 34 13 capture capture VB cord-307853-m1q1sjr4 34 14 the the DT cord-307853-m1q1sjr4 34 15 detailed detailed JJ cord-307853-m1q1sjr4 34 16 local local JJ cord-307853-m1q1sjr4 34 17 dynamics dynamic NNS cord-307853-m1q1sjr4 34 18 that that WDT cord-307853-m1q1sjr4 34 19 are be VBP cord-307853-m1q1sjr4 34 20 obtained obtain VBN cord-307853-m1q1sjr4 34 21 from from IN cord-307853-m1q1sjr4 34 22 all all DT cord-307853-m1q1sjr4 34 23 atom atom NN cord-307853-m1q1sjr4 34 24 molecular molecular JJ cord-307853-m1q1sjr4 34 25 dynamics dynamic NNS cord-307853-m1q1sjr4 34 26 simulation simulation NN cord-307853-m1q1sjr4 34 27 , , , cord-307853-m1q1sjr4 34 28 CG CG NNP cord-307853-m1q1sjr4 34 29 - - HYPH cord-307853-m1q1sjr4 34 30 NMA NMA NNP cord-307853-m1q1sjr4 34 31 has have VBZ cord-307853-m1q1sjr4 34 32 been be VBN cord-307853-m1q1sjr4 34 33 shown show VBN cord-307853-m1q1sjr4 34 34 to to TO cord-307853-m1q1sjr4 34 35 be be VB cord-307853-m1q1sjr4 34 36 equally equally RB cord-307853-m1q1sjr4 34 37 effective effective JJ cord-307853-m1q1sjr4 34 38 in in IN cord-307853-m1q1sjr4 34 39 J J NNP cord-307853-m1q1sjr4 34 40 o o NN cord-307853-m1q1sjr4 34 41 u u NN cord-307853-m1q1sjr4 34 42 r r NN cord-307853-m1q1sjr4 34 43 n n NN cord-307853-m1q1sjr4 34 44 a a DT cord-307853-m1q1sjr4 34 45 l l NN cord-307853-m1q1sjr4 34 46 P p NN cord-307853-m1q1sjr4 34 47 r r NN cord-307853-m1q1sjr4 34 48 e e NN cord-307853-m1q1sjr4 34 49 -p -p NN cord-307853-m1q1sjr4 35 1 r r NN cord-307853-m1q1sjr4 35 2 o o NN cord-307853-m1q1sjr4 35 3 o o NN cord-307853-m1q1sjr4 35 4 f f NN cord-307853-m1q1sjr4 35 5 demonstrating demonstrate VBG cord-307853-m1q1sjr4 35 6 the the DT cord-307853-m1q1sjr4 35 7 global global JJ cord-307853-m1q1sjr4 35 8 functional functional JJ cord-307853-m1q1sjr4 35 9 motions motion NNS cord-307853-m1q1sjr4 35 10 of of IN cord-307853-m1q1sjr4 35 11 proteins protein NNS cord-307853-m1q1sjr4 35 12 [ [ -LRB- cord-307853-m1q1sjr4 35 13 14 14 CD cord-307853-m1q1sjr4 35 14 , , , cord-307853-m1q1sjr4 35 15 15 15 CD cord-307853-m1q1sjr4 35 16 ] ] -RRB- cord-307853-m1q1sjr4 35 17 . . . cord-307853-m1q1sjr4 36 1 NMA NMA NNP cord-307853-m1q1sjr4 36 2 with with IN cord-307853-m1q1sjr4 36 3 anisotropic anisotropic JJ cord-307853-m1q1sjr4 36 4 network network NN cord-307853-m1q1sjr4 36 5 model model NN cord-307853-m1q1sjr4 36 6 ( ( -LRB- cord-307853-m1q1sjr4 36 7 ANM ANM NNP cord-307853-m1q1sjr4 36 8 ) ) -RRB- cord-307853-m1q1sjr4 36 9 , , , cord-307853-m1q1sjr4 36 10 a a DT cord-307853-m1q1sjr4 36 11 variant variant NN cord-307853-m1q1sjr4 36 12 of of IN cord-307853-m1q1sjr4 36 13 elastic elastic JJ cord-307853-m1q1sjr4 36 14 network network NN cord-307853-m1q1sjr4 36 15 model model NN cord-307853-m1q1sjr4 36 16 ( ( -LRB- cord-307853-m1q1sjr4 36 17 ENM ENM NNP cord-307853-m1q1sjr4 36 18 ) ) -RRB- cord-307853-m1q1sjr4 36 19 , , , cord-307853-m1q1sjr4 36 20 has have VBZ cord-307853-m1q1sjr4 36 21 been be VBN cord-307853-m1q1sjr4 36 22 proved prove VBN cord-307853-m1q1sjr4 36 23 to to TO cord-307853-m1q1sjr4 36 24 be be VB cord-307853-m1q1sjr4 36 25 successful successful JJ cord-307853-m1q1sjr4 36 26 in in IN cord-307853-m1q1sjr4 36 27 describing describe VBG cord-307853-m1q1sjr4 36 28 the the DT cord-307853-m1q1sjr4 36 29 collective collective JJ cord-307853-m1q1sjr4 36 30 dynamics dynamic NNS cord-307853-m1q1sjr4 36 31 of of IN cord-307853-m1q1sjr4 36 32 a a DT cord-307853-m1q1sjr4 36 33 wide wide JJ cord-307853-m1q1sjr4 36 34 range range NN cord-307853-m1q1sjr4 36 35 of of IN cord-307853-m1q1sjr4 36 36 biomolecular biomolecular JJ cord-307853-m1q1sjr4 36 37 systems system NNS cord-307853-m1q1sjr4 36 38 [ [ -LRB- cord-307853-m1q1sjr4 36 39 16 16 CD cord-307853-m1q1sjr4 36 40 ] ] -RRB- cord-307853-m1q1sjr4 36 41 [ [ -LRB- cord-307853-m1q1sjr4 36 42 17 17 CD cord-307853-m1q1sjr4 36 43 ] ] -RRB- cord-307853-m1q1sjr4 36 44 [ [ -LRB- cord-307853-m1q1sjr4 36 45 18 18 CD cord-307853-m1q1sjr4 36 46 ] ] -RRB- cord-307853-m1q1sjr4 36 47 . . . cord-307853-m1q1sjr4 37 1 Notable notable JJ cord-307853-m1q1sjr4 37 2 application application NN cord-307853-m1q1sjr4 37 3 of of IN cord-307853-m1q1sjr4 37 4 NMA NMA NNP cord-307853-m1q1sjr4 37 5 using use VBG cord-307853-m1q1sjr4 37 6 ANM ANM NNP cord-307853-m1q1sjr4 37 7 especially especially RB cord-307853-m1q1sjr4 37 8 in in IN cord-307853-m1q1sjr4 37 9 membrane membrane NN cord-307853-m1q1sjr4 37 10 proteins protein NNS cord-307853-m1q1sjr4 37 11 has have VBZ cord-307853-m1q1sjr4 37 12 been be VBN cord-307853-m1q1sjr4 37 13 thoroughly thoroughly RB cord-307853-m1q1sjr4 37 14 mentioned mention VBN cord-307853-m1q1sjr4 37 15 in in IN cord-307853-m1q1sjr4 37 16 the the DT cord-307853-m1q1sjr4 37 17 study study NN cord-307853-m1q1sjr4 37 18 and and CC cord-307853-m1q1sjr4 37 19 review review NN cord-307853-m1q1sjr4 37 20 done do VBN cord-307853-m1q1sjr4 37 21 by by IN cord-307853-m1q1sjr4 37 22 Bahar Bahar NNP cord-307853-m1q1sjr4 37 23 et et FW cord-307853-m1q1sjr4 37 24 al al NNP cord-307853-m1q1sjr4 37 25 [ [ -LRB- cord-307853-m1q1sjr4 37 26 19 19 CD cord-307853-m1q1sjr4 37 27 , , , cord-307853-m1q1sjr4 37 28 20 20 CD cord-307853-m1q1sjr4 37 29 ] ] -RRB- cord-307853-m1q1sjr4 37 30 . . . cord-307853-m1q1sjr4 38 1 In in IN cord-307853-m1q1sjr4 38 2 this this DT cord-307853-m1q1sjr4 38 3 study study NN cord-307853-m1q1sjr4 38 4 we -PRON- PRP cord-307853-m1q1sjr4 38 5 have have VBP cord-307853-m1q1sjr4 38 6 explored explore VBN cord-307853-m1q1sjr4 38 7 the the DT cord-307853-m1q1sjr4 38 8 intrinsic intrinsic JJ cord-307853-m1q1sjr4 38 9 dynamics dynamic NNS cord-307853-m1q1sjr4 38 10 of of IN cord-307853-m1q1sjr4 38 11 the the DT cord-307853-m1q1sjr4 38 12 closed closed JJ cord-307853-m1q1sjr4 38 13 or or CC cord-307853-m1q1sjr4 38 14 lying lie VBG cord-307853-m1q1sjr4 38 15 state state NN cord-307853-m1q1sjr4 38 16 spike spike NN cord-307853-m1q1sjr4 38 17 ( ( -LRB- cord-307853-m1q1sjr4 38 18 S s NN cord-307853-m1q1sjr4 38 19 ) ) -RRB- cord-307853-m1q1sjr4 38 20 glycoprotein glycoprotein NN cord-307853-m1q1sjr4 38 21 of of IN cord-307853-m1q1sjr4 38 22 SARS SARS NNP cord-307853-m1q1sjr4 38 23 - - HYPH cord-307853-m1q1sjr4 38 24 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 38 25 , , , cord-307853-m1q1sjr4 38 26 SARS SARS NNP cord-307853-m1q1sjr4 38 27 - - HYPH cord-307853-m1q1sjr4 38 28 CoV CoV NNP cord-307853-m1q1sjr4 38 29 and and CC cord-307853-m1q1sjr4 38 30 MERS MERS NNP cord-307853-m1q1sjr4 38 31 - - HYPH cord-307853-m1q1sjr4 38 32 CoV CoV NNP cord-307853-m1q1sjr4 38 33 through through IN cord-307853-m1q1sjr4 38 34 NMA NMA NNP cord-307853-m1q1sjr4 38 35 studies study NNS cord-307853-m1q1sjr4 38 36 using use VBG cord-307853-m1q1sjr4 38 37 ANM ANM NNP cord-307853-m1q1sjr4 38 38 . . . cord-307853-m1q1sjr4 39 1 We -PRON- PRP cord-307853-m1q1sjr4 39 2 found find VBD cord-307853-m1q1sjr4 39 3 noticeable noticeable JJ cord-307853-m1q1sjr4 39 4 variations variation NNS cord-307853-m1q1sjr4 39 5 in in IN cord-307853-m1q1sjr4 39 6 the the DT cord-307853-m1q1sjr4 39 7 dynamics dynamic NNS cord-307853-m1q1sjr4 39 8 of of IN cord-307853-m1q1sjr4 39 9 the the DT cord-307853-m1q1sjr4 39 10 proteins protein NNS cord-307853-m1q1sjr4 39 11 in in IN cord-307853-m1q1sjr4 39 12 different different JJ cord-307853-m1q1sjr4 39 13 low low JJ cord-307853-m1q1sjr4 39 14 frequency frequency NN cord-307853-m1q1sjr4 39 15 modes mode NNS cord-307853-m1q1sjr4 39 16 in in IN cord-307853-m1q1sjr4 39 17 terms term NNS cord-307853-m1q1sjr4 39 18 of of IN cord-307853-m1q1sjr4 39 19 both both DT cord-307853-m1q1sjr4 39 20 magnitude magnitude NN cord-307853-m1q1sjr4 39 21 and and CC cord-307853-m1q1sjr4 39 22 direction direction NN cord-307853-m1q1sjr4 39 23 of of IN cord-307853-m1q1sjr4 39 24 displacement displacement NN cord-307853-m1q1sjr4 39 25 vectors vector NNS cord-307853-m1q1sjr4 39 26 . . . cord-307853-m1q1sjr4 40 1 We -PRON- PRP cord-307853-m1q1sjr4 40 2 found find VBD cord-307853-m1q1sjr4 40 3 that that IN cord-307853-m1q1sjr4 40 4 receptor receptor NN cord-307853-m1q1sjr4 40 5 binding bind VBG cord-307853-m1q1sjr4 40 6 motif motif NN cord-307853-m1q1sjr4 40 7 ( ( -LRB- cord-307853-m1q1sjr4 40 8 RBM RBM NNP cord-307853-m1q1sjr4 40 9 ) ) -RRB- cord-307853-m1q1sjr4 40 10 of of IN cord-307853-m1q1sjr4 40 11 a a DT cord-307853-m1q1sjr4 40 12 single single JJ cord-307853-m1q1sjr4 40 13 chain chain NN cord-307853-m1q1sjr4 40 14 of of IN cord-307853-m1q1sjr4 40 15 SARS SARS NNP cord-307853-m1q1sjr4 40 16 - - HYPH cord-307853-m1q1sjr4 40 17 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 40 18 spike spike NN cord-307853-m1q1sjr4 40 19 show show VBP cord-307853-m1q1sjr4 40 20 high high JJ cord-307853-m1q1sjr4 40 21 fluctuation fluctuation NN cord-307853-m1q1sjr4 40 22 in in IN cord-307853-m1q1sjr4 40 23 the the DT cord-307853-m1q1sjr4 40 24 lying lie VBG cord-307853-m1q1sjr4 40 25 state state NN cord-307853-m1q1sjr4 40 26 indicating indicate VBG cord-307853-m1q1sjr4 40 27 its -PRON- PRP$ cord-307853-m1q1sjr4 40 28 high high JJ cord-307853-m1q1sjr4 40 29 probability probability NN cord-307853-m1q1sjr4 40 30 to to TO cord-307853-m1q1sjr4 40 31 bind bind VB cord-307853-m1q1sjr4 40 32 with with IN cord-307853-m1q1sjr4 40 33 the the DT cord-307853-m1q1sjr4 40 34 receptor receptor NN cord-307853-m1q1sjr4 40 35 implying imply VBG cord-307853-m1q1sjr4 40 36 the the DT cord-307853-m1q1sjr4 40 37 high high JJ cord-307853-m1q1sjr4 40 38 infectivity infectivity NN cord-307853-m1q1sjr4 40 39 of of IN cord-307853-m1q1sjr4 40 40 SARS SARS NNP cord-307853-m1q1sjr4 40 41 - - HYPH cord-307853-m1q1sjr4 40 42 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 40 43 than than IN cord-307853-m1q1sjr4 40 44 other other JJ cord-307853-m1q1sjr4 40 45 two two CD cord-307853-m1q1sjr4 40 46 viruses virus NNS cord-307853-m1q1sjr4 40 47 . . . cord-307853-m1q1sjr4 41 1 MERS MERS NNP cord-307853-m1q1sjr4 41 2 - - HYPH cord-307853-m1q1sjr4 41 3 CoV CoV NNP cord-307853-m1q1sjr4 41 4 S S NNP cord-307853-m1q1sjr4 41 5 shows show VBZ cord-307853-m1q1sjr4 41 6 distinct distinct JJ cord-307853-m1q1sjr4 41 7 dynamics dynamic NNS cord-307853-m1q1sjr4 41 8 than than IN cord-307853-m1q1sjr4 41 9 SARS SARS NNP cord-307853-m1q1sjr4 41 10 - - HYPH cord-307853-m1q1sjr4 41 11 CoV CoV NNP cord-307853-m1q1sjr4 41 12 S S NNP cord-307853-m1q1sjr4 41 13 and and CC cord-307853-m1q1sjr4 41 14 SARS SARS NNP cord-307853-m1q1sjr4 41 15 - - HYPH cord-307853-m1q1sjr4 41 16 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 41 17 S S NNP cord-307853-m1q1sjr4 41 18 indicates indicate VBZ cord-307853-m1q1sjr4 41 19 its -PRON- PRP$ cord-307853-m1q1sjr4 41 20 low low JJ cord-307853-m1q1sjr4 41 21 sequence sequence NN cord-307853-m1q1sjr4 41 22 similarity similarity NN cord-307853-m1q1sjr4 41 23 and and CC cord-307853-m1q1sjr4 41 24 distant distant JJ cord-307853-m1q1sjr4 41 25 phylogenetic phylogenetic JJ cord-307853-m1q1sjr4 41 26 relationship relationship NN cord-307853-m1q1sjr4 41 27 with with IN cord-307853-m1q1sjr4 41 28 other other JJ cord-307853-m1q1sjr4 41 29 . . . cord-307853-m1q1sjr4 42 1 Detailed detailed JJ cord-307853-m1q1sjr4 42 2 domain domain NN cord-307853-m1q1sjr4 42 3 - - HYPH cord-307853-m1q1sjr4 42 4 wise wise JJ cord-307853-m1q1sjr4 42 5 motion motion NN cord-307853-m1q1sjr4 42 6 , , , cord-307853-m1q1sjr4 42 7 atomic atomic JJ cord-307853-m1q1sjr4 42 8 fluctuation fluctuation NN cord-307853-m1q1sjr4 42 9 data datum NNS cord-307853-m1q1sjr4 42 10 and and CC cord-307853-m1q1sjr4 42 11 quantitative quantitative JJ cord-307853-m1q1sjr4 42 12 comparison comparison NN cord-307853-m1q1sjr4 42 13 between between IN cord-307853-m1q1sjr4 42 14 S S NNP cord-307853-m1q1sjr4 42 15 protein protein NN cord-307853-m1q1sjr4 42 16 structures structure NNS cord-307853-m1q1sjr4 42 17 of of IN cord-307853-m1q1sjr4 42 18 the the DT cord-307853-m1q1sjr4 42 19 mentioned mention VBN cord-307853-m1q1sjr4 42 20 viruses virus NNS cord-307853-m1q1sjr4 42 21 will will MD cord-307853-m1q1sjr4 42 22 aid aid VB cord-307853-m1q1sjr4 42 23 in in IN cord-307853-m1q1sjr4 42 24 identifying identify VBG cord-307853-m1q1sjr4 42 25 common common JJ cord-307853-m1q1sjr4 42 26 potential potential JJ cord-307853-m1q1sjr4 42 27 drug drug NN cord-307853-m1q1sjr4 42 28 binding bind VBG cord-307853-m1q1sjr4 42 29 hotspots hotspot NNS cord-307853-m1q1sjr4 42 30 in in IN cord-307853-m1q1sjr4 42 31 the the DT cord-307853-m1q1sjr4 42 32 receptor receptor NN cord-307853-m1q1sjr4 42 33 binding bind VBG cord-307853-m1q1sjr4 42 34 domain domain NN cord-307853-m1q1sjr4 42 35 of of IN cord-307853-m1q1sjr4 42 36 the the DT cord-307853-m1q1sjr4 42 37 protein protein NN cord-307853-m1q1sjr4 42 38 which which WDT cord-307853-m1q1sjr4 42 39 will will MD cord-307853-m1q1sjr4 42 40 guide guide VB cord-307853-m1q1sjr4 42 41 in in IN cord-307853-m1q1sjr4 42 42 designing design VBG cord-307853-m1q1sjr4 42 43 common common JJ cord-307853-m1q1sjr4 42 44 inhibitor inhibitor NN cord-307853-m1q1sjr4 42 45 or or CC cord-307853-m1q1sjr4 42 46 modified modify VBN cord-307853-m1q1sjr4 42 47 version version NN cord-307853-m1q1sjr4 42 48 of of IN cord-307853-m1q1sjr4 42 49 these these DT cord-307853-m1q1sjr4 42 50 molecules molecule NNS cord-307853-m1q1sjr4 42 51 through through IN cord-307853-m1q1sjr4 42 52 structure structure NN cord-307853-m1q1sjr4 42 53 - - HYPH cord-307853-m1q1sjr4 42 54 based base VBN cord-307853-m1q1sjr4 42 55 approach approach NN cord-307853-m1q1sjr4 42 56 . . . cord-307853-m1q1sjr4 43 1 J J NNP cord-307853-m1q1sjr4 43 2 o o NN cord-307853-m1q1sjr4 43 3 u u NN cord-307853-m1q1sjr4 43 4 r r NN cord-307853-m1q1sjr4 43 5 n n NN cord-307853-m1q1sjr4 43 6 a a DT cord-307853-m1q1sjr4 43 7 l l NN cord-307853-m1q1sjr4 43 8 P p NN cord-307853-m1q1sjr4 43 9 r r NN cord-307853-m1q1sjr4 43 10 e e NN cord-307853-m1q1sjr4 43 11 -p -p NN cord-307853-m1q1sjr4 44 1 r r LS cord-307853-m1q1sjr4 45 1 o o UH cord-307853-m1q1sjr4 46 1 o o UH cord-307853-m1q1sjr4 46 2 f f NNP cord-307853-m1q1sjr4 47 1 All all PDT cord-307853-m1q1sjr4 47 2 the the DT cord-307853-m1q1sjr4 47 3 X x NN cord-307853-m1q1sjr4 47 4 - - NN cord-307853-m1q1sjr4 47 5 ray ray NN cord-307853-m1q1sjr4 47 6 crystal crystal NN cord-307853-m1q1sjr4 47 7 structures structure NNS cord-307853-m1q1sjr4 47 8 for for IN cord-307853-m1q1sjr4 47 9 SARS SARS NNP cord-307853-m1q1sjr4 47 10 - - HYPH cord-307853-m1q1sjr4 47 11 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 47 12 , , , cord-307853-m1q1sjr4 47 13 SARS SARS NNP cord-307853-m1q1sjr4 47 14 - - HYPH cord-307853-m1q1sjr4 47 15 CoV CoV NNP cord-307853-m1q1sjr4 47 16 and and CC cord-307853-m1q1sjr4 47 17 MERS MERS NNP cord-307853-m1q1sjr4 47 18 - - HYPH cord-307853-m1q1sjr4 47 19 CoV CoV NNP cord-307853-m1q1sjr4 47 20 S S NNP cord-307853-m1q1sjr4 47 21 proteins protein NNS cord-307853-m1q1sjr4 47 22 in in IN cord-307853-m1q1sjr4 47 23 the the DT cord-307853-m1q1sjr4 47 24 lying lie VBG cord-307853-m1q1sjr4 47 25 state state NN cord-307853-m1q1sjr4 47 26 were be VBD cord-307853-m1q1sjr4 47 27 taken take VBN cord-307853-m1q1sjr4 47 28 from from IN cord-307853-m1q1sjr4 47 29 protein protein NN cord-307853-m1q1sjr4 47 30 data data NNP cord-307853-m1q1sjr4 47 31 bank bank NNP cord-307853-m1q1sjr4 47 32 [ [ -LRB- cord-307853-m1q1sjr4 47 33 21 21 CD cord-307853-m1q1sjr4 47 34 ] ] -RRB- cord-307853-m1q1sjr4 47 35 . . . cord-307853-m1q1sjr4 48 1 The the DT cord-307853-m1q1sjr4 48 2 corresponding corresponding JJ cord-307853-m1q1sjr4 48 3 PDB PDB NNP cord-307853-m1q1sjr4 48 4 IDs id NNS cord-307853-m1q1sjr4 48 5 are be VBP cord-307853-m1q1sjr4 48 6 6VXX 6vxx CD cord-307853-m1q1sjr4 48 7 , , , cord-307853-m1q1sjr4 48 8 5X58 5x58 CD cord-307853-m1q1sjr4 48 9 and and CC cord-307853-m1q1sjr4 48 10 6Q05 6q05 CD cord-307853-m1q1sjr4 48 11 respectively respectively RB cord-307853-m1q1sjr4 48 12 [ [ -LRB- cord-307853-m1q1sjr4 48 13 11 11 CD cord-307853-m1q1sjr4 48 14 , , , cord-307853-m1q1sjr4 48 15 22 22 CD cord-307853-m1q1sjr4 48 16 , , , cord-307853-m1q1sjr4 48 17 23 23 CD cord-307853-m1q1sjr4 48 18 ] ] -RRB- cord-307853-m1q1sjr4 48 19 . . . cord-307853-m1q1sjr4 49 1 CHARM charm NN cord-307853-m1q1sjr4 49 2 - - HYPH cord-307853-m1q1sjr4 49 3 GUI GUI NNP cord-307853-m1q1sjr4 49 4 was be VBD cord-307853-m1q1sjr4 49 5 used use VBN cord-307853-m1q1sjr4 49 6 to to TO cord-307853-m1q1sjr4 49 7 prepare prepare VB cord-307853-m1q1sjr4 49 8 the the DT cord-307853-m1q1sjr4 49 9 protein protein NN cord-307853-m1q1sjr4 49 10 ( ( -LRB- cord-307853-m1q1sjr4 50 1 i.e i.e XX cord-307853-m1q1sjr4 50 2 adding add VBG cord-307853-m1q1sjr4 50 3 missing miss VBG cord-307853-m1q1sjr4 50 4 atoms atom NNS cord-307853-m1q1sjr4 50 5 and and CC cord-307853-m1q1sjr4 50 6 assigning assign VBG cord-307853-m1q1sjr4 50 7 correct correct JJ cord-307853-m1q1sjr4 50 8 protonation protonation JJ cord-307853-m1q1sjr4 50 9 states state NNS cord-307853-m1q1sjr4 50 10 ) ) -RRB- cord-307853-m1q1sjr4 51 1 [ [ -LRB- cord-307853-m1q1sjr4 51 2 24 24 CD cord-307853-m1q1sjr4 51 3 ] ] -RRB- cord-307853-m1q1sjr4 51 4 . . . cord-307853-m1q1sjr4 52 1 As as IN cord-307853-m1q1sjr4 52 2 a a DT cord-307853-m1q1sjr4 52 3 large large JJ cord-307853-m1q1sjr4 52 4 part part NN cord-307853-m1q1sjr4 52 5 of of IN cord-307853-m1q1sjr4 52 6 this this DT cord-307853-m1q1sjr4 52 7 study study NN cord-307853-m1q1sjr4 52 8 is be VBZ cord-307853-m1q1sjr4 52 9 involved involve VBN cord-307853-m1q1sjr4 52 10 in in IN cord-307853-m1q1sjr4 52 11 the the DT cord-307853-m1q1sjr4 52 12 comparative comparative JJ cord-307853-m1q1sjr4 52 13 analysis analysis NN cord-307853-m1q1sjr4 52 14 purposes purpose NNS cord-307853-m1q1sjr4 52 15 , , , cord-307853-m1q1sjr4 52 16 we -PRON- PRP cord-307853-m1q1sjr4 52 17 have have VBP cord-307853-m1q1sjr4 52 18 discarded discard VBN cord-307853-m1q1sjr4 52 19 part part NN cord-307853-m1q1sjr4 52 20 of of IN cord-307853-m1q1sjr4 52 21 the the DT cord-307853-m1q1sjr4 52 22 S2 S2 NNP cord-307853-m1q1sjr4 52 23 region region NN cord-307853-m1q1sjr4 52 24 of of IN cord-307853-m1q1sjr4 52 25 S S NNP cord-307853-m1q1sjr4 52 26 protein protein NN cord-307853-m1q1sjr4 52 27 of of IN cord-307853-m1q1sjr4 52 28 all all DT cord-307853-m1q1sjr4 52 29 viral viral JJ cord-307853-m1q1sjr4 52 30 strains strain NNS cord-307853-m1q1sjr4 52 31 so so IN cord-307853-m1q1sjr4 52 32 that that IN cord-307853-m1q1sjr4 52 33 each each DT cord-307853-m1q1sjr4 52 34 protein protein NN cord-307853-m1q1sjr4 52 35 model model NN cord-307853-m1q1sjr4 52 36 has have VBZ cord-307853-m1q1sjr4 52 37 equal equal JJ cord-307853-m1q1sjr4 52 38 number number NN cord-307853-m1q1sjr4 52 39 of of IN cord-307853-m1q1sjr4 52 40 Cα Cα NNP cord-307853-m1q1sjr4 52 41 atoms atom NNS cord-307853-m1q1sjr4 52 42 ( ( -LRB- cord-307853-m1q1sjr4 52 43 1087 1087 CD cord-307853-m1q1sjr4 52 44 in in IN cord-307853-m1q1sjr4 52 45 all all DT cord-307853-m1q1sjr4 52 46 three three CD cord-307853-m1q1sjr4 52 47 chains chain NNS cord-307853-m1q1sjr4 52 48 ) ) -RRB- cord-307853-m1q1sjr4 52 49 . . . cord-307853-m1q1sjr4 53 1 S2 S2 NNP cord-307853-m1q1sjr4 53 2 region region NN cord-307853-m1q1sjr4 53 3 of of IN cord-307853-m1q1sjr4 53 4 the the DT cord-307853-m1q1sjr4 53 5 protein protein NN cord-307853-m1q1sjr4 53 6 does do VBZ cord-307853-m1q1sjr4 53 7 not not RB cord-307853-m1q1sjr4 53 8 take take VB cord-307853-m1q1sjr4 53 9 active active JJ cord-307853-m1q1sjr4 53 10 part part NN cord-307853-m1q1sjr4 53 11 in in IN cord-307853-m1q1sjr4 53 12 receptor receptor NN cord-307853-m1q1sjr4 53 13 interaction interaction NN cord-307853-m1q1sjr4 53 14 . . . cord-307853-m1q1sjr4 54 1 Detailed detailed JJ cord-307853-m1q1sjr4 54 2 mathematical mathematical JJ cord-307853-m1q1sjr4 54 3 description description NN cord-307853-m1q1sjr4 54 4 about about IN cord-307853-m1q1sjr4 54 5 normal normal JJ cord-307853-m1q1sjr4 54 6 mode mode NN cord-307853-m1q1sjr4 54 7 analysis analysis NN cord-307853-m1q1sjr4 54 8 and and CC cord-307853-m1q1sjr4 54 9 how how WRB cord-307853-m1q1sjr4 54 10 it -PRON- PRP cord-307853-m1q1sjr4 54 11 is be VBZ cord-307853-m1q1sjr4 54 12 applicable applicable JJ cord-307853-m1q1sjr4 54 13 to to IN cord-307853-m1q1sjr4 54 14 protein protein NN cord-307853-m1q1sjr4 54 15 molecule molecule NN cord-307853-m1q1sjr4 54 16 is be VBZ cord-307853-m1q1sjr4 54 17 given give VBN cord-307853-m1q1sjr4 54 18 in in IN cord-307853-m1q1sjr4 54 19 many many JJ cord-307853-m1q1sjr4 54 20 studies study NNS cord-307853-m1q1sjr4 54 21 [ [ -LRB- cord-307853-m1q1sjr4 54 22 20 20 CD cord-307853-m1q1sjr4 54 23 , , , cord-307853-m1q1sjr4 54 24 [ [ -LRB- cord-307853-m1q1sjr4 54 25 25 25 CD cord-307853-m1q1sjr4 54 26 ] ] -RRB- cord-307853-m1q1sjr4 54 27 [ [ -LRB- cord-307853-m1q1sjr4 54 28 26 26 CD cord-307853-m1q1sjr4 54 29 ] ] -RRB- cord-307853-m1q1sjr4 54 30 [ [ -LRB- cord-307853-m1q1sjr4 54 31 27 27 CD cord-307853-m1q1sjr4 54 32 ] ] -RRB- cord-307853-m1q1sjr4 54 33 . . . cord-307853-m1q1sjr4 55 1 NMA NMA NNP cord-307853-m1q1sjr4 55 2 is be VBZ cord-307853-m1q1sjr4 55 3 a a DT cord-307853-m1q1sjr4 55 4 technique technique NN cord-307853-m1q1sjr4 55 5 to to TO cord-307853-m1q1sjr4 55 6 study study VB cord-307853-m1q1sjr4 55 7 vibrational vibrational JJ cord-307853-m1q1sjr4 55 8 motion motion NN cord-307853-m1q1sjr4 55 9 of of IN cord-307853-m1q1sjr4 55 10 harmonic harmonic JJ cord-307853-m1q1sjr4 55 11 oscillating oscillating JJ cord-307853-m1q1sjr4 55 12 system system NN cord-307853-m1q1sjr4 55 13 near near IN cord-307853-m1q1sjr4 55 14 the the DT cord-307853-m1q1sjr4 55 15 equilibrium equilibrium NN cord-307853-m1q1sjr4 55 16 state state NN cord-307853-m1q1sjr4 55 17 . . . cord-307853-m1q1sjr4 56 1 The the DT cord-307853-m1q1sjr4 56 2 motions motion NNS cord-307853-m1q1sjr4 56 3 are be VBP cord-307853-m1q1sjr4 56 4 of of IN cord-307853-m1q1sjr4 56 5 small small JJ cord-307853-m1q1sjr4 56 6 amplitude amplitude NN cord-307853-m1q1sjr4 56 7 in in IN cord-307853-m1q1sjr4 56 8 a a DT cord-307853-m1q1sjr4 56 9 potential potential JJ cord-307853-m1q1sjr4 56 10 well well NN cord-307853-m1q1sjr4 56 11 and and CC cord-307853-m1q1sjr4 56 12 can can MD cord-307853-m1q1sjr4 56 13 not not RB cord-307853-m1q1sjr4 56 14 cross cross VB cord-307853-m1q1sjr4 56 15 energy energy NN cord-307853-m1q1sjr4 56 16 barriers barrier NNS cord-307853-m1q1sjr4 56 17 . . . cord-307853-m1q1sjr4 57 1 At at IN cord-307853-m1q1sjr4 57 2 a a DT cord-307853-m1q1sjr4 57 3 minimum minimum JJ cord-307853-m1q1sjr4 57 4 state state NN cord-307853-m1q1sjr4 57 5 , , , cord-307853-m1q1sjr4 57 6 the the DT cord-307853-m1q1sjr4 57 7 potential potential JJ cord-307853-m1q1sjr4 57 8 energy energy NN cord-307853-m1q1sjr4 57 9 V v NN cord-307853-m1q1sjr4 57 10 can can MD cord-307853-m1q1sjr4 57 11 be be VB cord-307853-m1q1sjr4 57 12 obtained obtain VBN cord-307853-m1q1sjr4 57 13 from from IN cord-307853-m1q1sjr4 57 14 the the DT cord-307853-m1q1sjr4 57 15 approximation approximation NN cord-307853-m1q1sjr4 57 16 of of IN cord-307853-m1q1sjr4 57 17 Taylor Taylor NNP cord-307853-m1q1sjr4 57 18 series series NN cord-307853-m1q1sjr4 57 19 expansion expansion NN cord-307853-m1q1sjr4 57 20 . . . cord-307853-m1q1sjr4 58 1 For for IN cord-307853-m1q1sjr4 58 2 the the DT cord-307853-m1q1sjr4 58 3 generalized generalized JJ cord-307853-m1q1sjr4 58 4 coordinates coordinate NNS cord-307853-m1q1sjr4 58 5 : : : cord-307853-m1q1sjr4 58 6 Where where WRB cord-307853-m1q1sjr4 58 7 specifies specify VBZ cord-307853-m1q1sjr4 58 8 the the DT cord-307853-m1q1sjr4 58 9 deviation deviation NN cord-307853-m1q1sjr4 58 10 from from IN cord-307853-m1q1sjr4 58 11 equilibrium equilibrium NN cord-307853-m1q1sjr4 58 12 ( ( -LRB- cord-307853-m1q1sjr4 58 13 = = NN cord-307853-m1q1sjr4 58 14 + + NN cord-307853-m1q1sjr4 58 15 ) ) -RRB- cord-307853-m1q1sjr4 58 16 . . . cord-307853-m1q1sjr4 59 1 The the DT cord-307853-m1q1sjr4 59 2 kinetic kinetic JJ cord-307853-m1q1sjr4 59 3 energy energy NN cord-307853-m1q1sjr4 59 4 T T NNP cord-307853-m1q1sjr4 59 5 also also RB cord-307853-m1q1sjr4 59 6 approximated approximate VBD cord-307853-m1q1sjr4 59 7 from from IN cord-307853-m1q1sjr4 59 8 Taylor Taylor NNP cord-307853-m1q1sjr4 59 9 expansion expansion NN cord-307853-m1q1sjr4 59 10 . . . cord-307853-m1q1sjr4 60 1 The the DT cord-307853-m1q1sjr4 60 2 resulting result VBG cord-307853-m1q1sjr4 60 3 Lagrangian Lagrangian NNP cord-307853-m1q1sjr4 60 4 is be VBZ cord-307853-m1q1sjr4 60 5 L l NN cord-307853-m1q1sjr4 60 6 = = SYM cord-307853-m1q1sjr4 60 7 T t NN cord-307853-m1q1sjr4 60 8 - - HYPH cord-307853-m1q1sjr4 60 9 V V NNP cord-307853-m1q1sjr4 60 10 , , , cord-307853-m1q1sjr4 60 11 which which WDT cord-307853-m1q1sjr4 60 12 results result VBZ cord-307853-m1q1sjr4 60 13 in in IN cord-307853-m1q1sjr4 60 14 linear linear JJ cord-307853-m1q1sjr4 60 15 differential differential JJ cord-307853-m1q1sjr4 60 16 equations equation NNS cord-307853-m1q1sjr4 60 17 of of IN cord-307853-m1q1sjr4 60 18 motion motion NN cord-307853-m1q1sjr4 60 19 : : : cord-307853-m1q1sjr4 61 1 Assuming assume VBG cord-307853-m1q1sjr4 61 2 oscillatory oscillatory JJ cord-307853-m1q1sjr4 61 3 solution solution NN cord-307853-m1q1sjr4 61 4 , , , cord-307853-m1q1sjr4 61 5 = = FW cord-307853-m1q1sjr4 61 6 cos cos NNP cord-307853-m1q1sjr4 61 7 ( ( -LRB- cord-307853-m1q1sjr4 61 8 + + CC cord-307853-m1q1sjr4 61 9 ) ) -RRB- cord-307853-m1q1sjr4 61 10 and and CC cord-307853-m1q1sjr4 61 11 substituting substitute VBG cord-307853-m1q1sjr4 61 12 it -PRON- PRP cord-307853-m1q1sjr4 61 13 in in IN cord-307853-m1q1sjr4 61 14 equation equation NN cord-307853-m1q1sjr4 61 15 2 2 CD cord-307853-m1q1sjr4 61 16 results result NNS cord-307853-m1q1sjr4 61 17 in in IN cord-307853-m1q1sjr4 61 18 eigenvalue eigenvalue NN cord-307853-m1q1sjr4 61 19 problem problem NN cord-307853-m1q1sjr4 62 1 : : : cord-307853-m1q1sjr4 62 2 A a DT cord-307853-m1q1sjr4 62 3 is be VBZ cord-307853-m1q1sjr4 62 4 the the DT cord-307853-m1q1sjr4 62 5 matrix matrix NN cord-307853-m1q1sjr4 62 6 of of IN cord-307853-m1q1sjr4 62 7 amplitudes amplitude NNS cord-307853-m1q1sjr4 62 8 , , , cord-307853-m1q1sjr4 62 9 and and CC cord-307853-m1q1sjr4 62 10 V v NN cord-307853-m1q1sjr4 62 11 is be VBZ cord-307853-m1q1sjr4 62 12 the the DT cord-307853-m1q1sjr4 62 13 matrix matrix NN cord-307853-m1q1sjr4 62 14 of of IN cord-307853-m1q1sjr4 62 15 the the DT cord-307853-m1q1sjr4 62 16 second second JJ cord-307853-m1q1sjr4 62 17 derivative derivative NN cord-307853-m1q1sjr4 62 18 of of IN cord-307853-m1q1sjr4 62 19 the the DT cord-307853-m1q1sjr4 62 20 potential potential JJ cord-307853-m1q1sjr4 62 21 energy energy NN cord-307853-m1q1sjr4 62 22 and and CC cord-307853-m1q1sjr4 62 23 is be VBZ cord-307853-m1q1sjr4 62 24 referred refer VBN cord-307853-m1q1sjr4 62 25 to to IN cord-307853-m1q1sjr4 62 26 as as IN cord-307853-m1q1sjr4 62 27 Hessian Hessian NNP cord-307853-m1q1sjr4 62 28 . . . cord-307853-m1q1sjr4 63 1 $ $ $ cord-307853-m1q1sjr4 63 2 is be VBZ cord-307853-m1q1sjr4 63 3 a a DT cord-307853-m1q1sjr4 63 4 diagonal diagonal JJ cord-307853-m1q1sjr4 63 5 matrix matrix NN cord-307853-m1q1sjr4 63 6 of of IN cord-307853-m1q1sjr4 63 7 eigenvalues eigenvalue NNS cord-307853-m1q1sjr4 63 8 . . . cord-307853-m1q1sjr4 64 1 The the DT cord-307853-m1q1sjr4 64 2 pattern pattern NN cord-307853-m1q1sjr4 64 3 of of IN cord-307853-m1q1sjr4 64 4 motions motion NNS cord-307853-m1q1sjr4 64 5 is be VBZ cord-307853-m1q1sjr4 64 6 fully fully RB cord-307853-m1q1sjr4 64 7 specified specify VBN cord-307853-m1q1sjr4 64 8 by by IN cord-307853-m1q1sjr4 64 9 the the DT cord-307853-m1q1sjr4 64 10 vibrational vibrational JJ cord-307853-m1q1sjr4 64 11 normal normal JJ cord-307853-m1q1sjr4 64 12 modes mode NNS cord-307853-m1q1sjr4 64 13 , , , cord-307853-m1q1sjr4 64 14 i.e. i.e. FW cord-307853-m1q1sjr4 64 15 the the DT cord-307853-m1q1sjr4 64 16 eigenvectors eigenvector NNS cord-307853-m1q1sjr4 64 17 ( ( -LRB- cord-307853-m1q1sjr4 64 18 % % NN cord-307853-m1q1sjr4 64 19 ) ) -RRB- cord-307853-m1q1sjr4 64 20 and and CC cord-307853-m1q1sjr4 64 21 their -PRON- PRP$ cord-307853-m1q1sjr4 64 22 associated associate VBN cord-307853-m1q1sjr4 64 23 eigenvalues eigenvalue NNS cord-307853-m1q1sjr4 64 24 ( ( -LRB- cord-307853-m1q1sjr4 64 25 $ $ $ cord-307853-m1q1sjr4 64 26 ) ) -RRB- cord-307853-m1q1sjr4 64 27 . . . cord-307853-m1q1sjr4 65 1 The the DT cord-307853-m1q1sjr4 65 2 vector vector NN cord-307853-m1q1sjr4 65 3 describes describe VBZ cord-307853-m1q1sjr4 65 4 the the DT cord-307853-m1q1sjr4 65 5 directionality directionality NN cord-307853-m1q1sjr4 65 6 and and CC cord-307853-m1q1sjr4 65 7 magnitude magnitude NN cord-307853-m1q1sjr4 65 8 of of IN cord-307853-m1q1sjr4 65 9 motion motion NN cord-307853-m1q1sjr4 65 10 of of IN cord-307853-m1q1sjr4 65 11 each each DT cord-307853-m1q1sjr4 65 12 particle particle NN cord-307853-m1q1sjr4 65 13 relative relative JJ cord-307853-m1q1sjr4 65 14 to to IN cord-307853-m1q1sjr4 65 15 other other JJ cord-307853-m1q1sjr4 65 16 particles particle NNS cord-307853-m1q1sjr4 65 17 . . . cord-307853-m1q1sjr4 65 18 _SP cord-307853-m1q1sjr4 66 1 Here here RB cord-307853-m1q1sjr4 66 2 . . . cord-307853-m1q1sjr4 67 1 and and CC cord-307853-m1q1sjr4 67 2 . . . cord-307853-m1q1sjr4 68 1 are be VBP cord-307853-m1q1sjr4 68 2 instantaneous instantaneous JJ cord-307853-m1q1sjr4 68 3 and and CC cord-307853-m1q1sjr4 68 4 equilibrium equilibrium JJ cord-307853-m1q1sjr4 68 5 distances distance NNS cord-307853-m1q1sjr4 68 6 between between IN cord-307853-m1q1sjr4 68 7 the the DT cord-307853-m1q1sjr4 68 8 nodes node NNS cord-307853-m1q1sjr4 68 9 i i PRP cord-307853-m1q1sjr4 68 10 and and CC cord-307853-m1q1sjr4 68 11 j j NNP cord-307853-m1q1sjr4 68 12 , , , cord-307853-m1q1sjr4 68 13 ( ( -LRB- cord-307853-m1q1sjr4 68 14 is be VBZ cord-307853-m1q1sjr4 68 15 _SP cord-307853-m1q1sjr4 69 1 Here here RB cord-307853-m1q1sjr4 69 2 we -PRON- PRP cord-307853-m1q1sjr4 69 3 consider consider VBP cord-307853-m1q1sjr4 69 4 ( ( -LRB- cord-307853-m1q1sjr4 69 5 3N 3n CD cord-307853-m1q1sjr4 69 6 -6 -6 CD cord-307853-m1q1sjr4 69 7 ) ) -RRB- cord-307853-m1q1sjr4 69 8 non non JJ cord-307853-m1q1sjr4 69 9 zero zero CD cord-307853-m1q1sjr4 69 10 modes mode NNS cord-307853-m1q1sjr4 69 11 , , , cord-307853-m1q1sjr4 69 12 $ $ $ cord-307853-m1q1sjr4 69 13 corresponds correspond VBZ cord-307853-m1q1sjr4 69 14 to to IN cord-307853-m1q1sjr4 69 15 eigenvalues eigenvalue NNS cord-307853-m1q1sjr4 69 16 and and CC cord-307853-m1q1sjr4 69 17 the the DT cord-307853-m1q1sjr4 69 18 corresponding correspond VBG cord-307853-m1q1sjr4 69 19 eigenvectors eigenvector NNS cord-307853-m1q1sjr4 69 20 are be VBP cord-307853-m1q1sjr4 69 21 7 7 CD cord-307853-m1q1sjr4 69 22 . . . cord-307853-m1q1sjr4 70 1 The the DT cord-307853-m1q1sjr4 70 2 inverse inverse NN cord-307853-m1q1sjr4 70 3 H h NN cord-307853-m1q1sjr4 70 4 -1 -1 NN cord-307853-m1q1sjr4 70 5 is be VBZ cord-307853-m1q1sjr4 70 6 also also RB cord-307853-m1q1sjr4 70 7 organized organize VBN cord-307853-m1q1sjr4 70 8 in in IN cord-307853-m1q1sjr4 70 9 N N NNP cord-307853-m1q1sjr4 70 10 x x SYM cord-307853-m1q1sjr4 70 11 N n CD cord-307853-m1q1sjr4 70 12 submatrices submatrice NNS cord-307853-m1q1sjr4 70 13 of of IN cord-307853-m1q1sjr4 70 14 size size NN cord-307853-m1q1sjr4 70 15 3 3 CD cord-307853-m1q1sjr4 70 16 x x SYM cord-307853-m1q1sjr4 70 17 3 3 CD cord-307853-m1q1sjr4 70 18 , , , cord-307853-m1q1sjr4 70 19 each each DT cord-307853-m1q1sjr4 70 20 . . . cord-307853-m1q1sjr4 71 1 The the DT cord-307853-m1q1sjr4 71 2 ij ij NN cord-307853-m1q1sjr4 71 3 th th XX cord-307853-m1q1sjr4 71 4 submatrix submatrix NNP cord-307853-m1q1sjr4 71 5 H H NNP cord-307853-m1q1sjr4 71 6 ij ij NN cord-307853-m1q1sjr4 71 7 -1 -1 NNP cord-307853-m1q1sjr4 71 8 defines define VBZ cord-307853-m1q1sjr4 71 9 the the DT cord-307853-m1q1sjr4 71 10 covariance covariance NN cord-307853-m1q1sjr4 71 11 between between IN cord-307853-m1q1sjr4 71 12 the the DT cord-307853-m1q1sjr4 71 13 fluctuations fluctuation NNS cord-307853-m1q1sjr4 71 14 of of IN cord-307853-m1q1sjr4 71 15 residues residue NNS cord-307853-m1q1sjr4 71 16 i i PRP cord-307853-m1q1sjr4 71 17 and and CC cord-307853-m1q1sjr4 71 18 j. j. NNP cord-307853-m1q1sjr4 71 19 The the DT cord-307853-m1q1sjr4 71 20 cross cross JJ cord-307853-m1q1sjr4 71 21 - - JJ cord-307853-m1q1sjr4 71 22 correlation correlation NN cord-307853-m1q1sjr4 71 23 ( ( -LRB- cord-307853-m1q1sjr4 71 24 CC cc NN cord-307853-m1q1sjr4 71 25 ) ) -RRB- cord-307853-m1q1sjr4 71 26 between between IN cord-307853-m1q1sjr4 71 27 the the DT cord-307853-m1q1sjr4 71 28 equilibrium equilibrium NN cord-307853-m1q1sjr4 71 29 fluctuations fluctuation NNS cord-307853-m1q1sjr4 71 30 of of IN cord-307853-m1q1sjr4 71 31 residues residue NNS cord-307853-m1q1sjr4 71 32 i i PRP cord-307853-m1q1sjr4 71 33 and and CC cord-307853-m1q1sjr4 71 34 j j NNP cord-307853-m1q1sjr4 71 35 , , , cord-307853-m1q1sjr4 71 36 8Δ9 8δ9 CD cord-307853-m1q1sjr4 71 37 • • NN cord-307853-m1q1sjr4 71 38 Δ9 δ9 NN cord-307853-m1q1sjr4 71 39 ; ; : cord-307853-m1q1sjr4 71 40 is be VBZ cord-307853-m1q1sjr4 71 41 expressed express VBN cord-307853-m1q1sjr4 71 42 in in IN cord-307853-m1q1sjr4 71 43 terms term NNS cord-307853-m1q1sjr4 71 44 of of IN cord-307853-m1q1sjr4 71 45 the the DT cord-307853-m1q1sjr4 71 46 trace trace NN cord-307853-m1q1sjr4 71 47 ( ( -LRB- cord-307853-m1q1sjr4 71 48 tr tr NN cord-307853-m1q1sjr4 71 49 ) ) -RRB- cord-307853-m1q1sjr4 71 50 of of IN cord-307853-m1q1sjr4 71 51 these these DT cord-307853-m1q1sjr4 71 52 submatrices submatrice NNS cord-307853-m1q1sjr4 71 53 as as IN cord-307853-m1q1sjr4 71 54 : : : cord-307853-m1q1sjr4 71 55 We -PRON- PRP cord-307853-m1q1sjr4 71 56 have have VBP cord-307853-m1q1sjr4 71 57 performed perform VBN cord-307853-m1q1sjr4 71 58 the the DT cord-307853-m1q1sjr4 71 59 NMA NMA NNP cord-307853-m1q1sjr4 71 60 and and CC cord-307853-m1q1sjr4 71 61 all all PDT cord-307853-m1q1sjr4 71 62 the the DT cord-307853-m1q1sjr4 71 63 analysis analysis NN cord-307853-m1q1sjr4 71 64 functions function NNS cord-307853-m1q1sjr4 71 65 including include VBG cord-307853-m1q1sjr4 71 66 root root NN cord-307853-m1q1sjr4 71 67 mean mean NN cord-307853-m1q1sjr4 71 68 squared squared JJ cord-307853-m1q1sjr4 71 69 inner inner JJ cord-307853-m1q1sjr4 71 70 product product NN cord-307853-m1q1sjr4 71 71 ( ( -LRB- cord-307853-m1q1sjr4 71 72 RMSIP RMSIP NNP cord-307853-m1q1sjr4 71 73 ) ) -RRB- cord-307853-m1q1sjr4 71 74 [ [ -LRB- cord-307853-m1q1sjr4 71 75 28 28 CD cord-307853-m1q1sjr4 71 76 ] ] -RRB- cord-307853-m1q1sjr4 71 77 , , , cord-307853-m1q1sjr4 71 78 spectral spectral JJ cord-307853-m1q1sjr4 71 79 overlap overlap NN cord-307853-m1q1sjr4 71 80 [ [ -LRB- cord-307853-m1q1sjr4 71 81 29 29 CD cord-307853-m1q1sjr4 71 82 ] ] -RRB- cord-307853-m1q1sjr4 71 83 and and CC cord-307853-m1q1sjr4 71 84 cosine cosine NN cord-307853-m1q1sjr4 71 85 correlation correlation NN cord-307853-m1q1sjr4 71 86 or or CC cord-307853-m1q1sjr4 71 87 overlap overlap VBP cord-307853-m1q1sjr4 71 88 [ [ -LRB- cord-307853-m1q1sjr4 71 89 30 30 CD cord-307853-m1q1sjr4 71 90 ] ] -RRB- cord-307853-m1q1sjr4 71 91 using use VBG cord-307853-m1q1sjr4 71 92 ProDy ProDy NNP cord-307853-m1q1sjr4 71 93 python python NN cord-307853-m1q1sjr4 71 94 package package NN cord-307853-m1q1sjr4 71 95 [ [ -LRB- cord-307853-m1q1sjr4 71 96 31 31 CD cord-307853-m1q1sjr4 71 97 ] ] -RRB- cord-307853-m1q1sjr4 71 98 . . . cord-307853-m1q1sjr4 72 1 RMSIP RMSIP NNP cord-307853-m1q1sjr4 72 2 computes compute VBZ cord-307853-m1q1sjr4 72 3 quantitative quantitative JJ cord-307853-m1q1sjr4 72 4 comparison comparison NN cord-307853-m1q1sjr4 72 5 value value NN cord-307853-m1q1sjr4 72 6 between between IN cord-307853-m1q1sjr4 72 7 the the DT cord-307853-m1q1sjr4 72 8 sets set NNS cord-307853-m1q1sjr4 72 9 of of IN cord-307853-m1q1sjr4 72 10 normal normal JJ cord-307853-m1q1sjr4 72 11 modes mode NNS cord-307853-m1q1sjr4 72 12 and and CC cord-307853-m1q1sjr4 72 13 expressed express VBD cord-307853-m1q1sjr4 72 14 as as IN cord-307853-m1q1sjr4 72 15 : : : cord-307853-m1q1sjr4 72 16 Structural structural JJ cord-307853-m1q1sjr4 72 17 alignments alignment NNS cord-307853-m1q1sjr4 72 18 of of IN cord-307853-m1q1sjr4 72 19 the the DT cord-307853-m1q1sjr4 72 20 models model NNS cord-307853-m1q1sjr4 72 21 were be VBD cord-307853-m1q1sjr4 72 22 done do VBN cord-307853-m1q1sjr4 72 23 using use VBG cord-307853-m1q1sjr4 72 24 PyMol PyMol NNP cord-307853-m1q1sjr4 72 25 . . . cord-307853-m1q1sjr4 73 1 We -PRON- PRP cord-307853-m1q1sjr4 73 2 have have VBP cord-307853-m1q1sjr4 73 3 computed compute VBN cord-307853-m1q1sjr4 73 4 the the DT cord-307853-m1q1sjr4 73 5 eigenvalues eigenvalue NNS cord-307853-m1q1sjr4 73 6 of of IN cord-307853-m1q1sjr4 73 7 first first JJ cord-307853-m1q1sjr4 73 8 hundred hundred CD cord-307853-m1q1sjr4 73 9 non non JJ cord-307853-m1q1sjr4 73 10 - - JJ cord-307853-m1q1sjr4 73 11 zero zero CD cord-307853-m1q1sjr4 73 12 normal normal JJ cord-307853-m1q1sjr4 73 13 modes mode NNS cord-307853-m1q1sjr4 73 14 of of IN cord-307853-m1q1sjr4 73 15 the the DT cord-307853-m1q1sjr4 73 16 SARS SARS NNP cord-307853-m1q1sjr4 73 17 - - HYPH cord-307853-m1q1sjr4 73 18 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 73 19 , , , cord-307853-m1q1sjr4 73 20 SARS SARS NNP cord-307853-m1q1sjr4 73 21 - - HYPH cord-307853-m1q1sjr4 73 22 CoV CoV NNP cord-307853-m1q1sjr4 73 23 , , , cord-307853-m1q1sjr4 73 24 and and CC cord-307853-m1q1sjr4 73 25 MERS MERS NNP cord-307853-m1q1sjr4 73 26 - - HYPH cord-307853-m1q1sjr4 73 27 CoV cov NN cord-307853-m1q1sjr4 73 28 spike spike NN cord-307853-m1q1sjr4 73 29 ( ( -LRB- cord-307853-m1q1sjr4 73 30 S s NN cord-307853-m1q1sjr4 73 31 ) ) -RRB- cord-307853-m1q1sjr4 73 32 proteins protein NNS cord-307853-m1q1sjr4 73 33 in in IN cord-307853-m1q1sjr4 73 34 the the DT cord-307853-m1q1sjr4 73 35 lying lying NN cord-307853-m1q1sjr4 73 36 state state NN cord-307853-m1q1sjr4 74 1 ( ( -LRB- cord-307853-m1q1sjr4 74 2 Fig Fig NNP cord-307853-m1q1sjr4 74 3 . . NNP cord-307853-m1q1sjr4 74 4 1 1 CD cord-307853-m1q1sjr4 74 5 ) ) -RRB- cord-307853-m1q1sjr4 74 6 . . . cord-307853-m1q1sjr4 75 1 The the DT cord-307853-m1q1sjr4 75 2 energy energy NN cord-307853-m1q1sjr4 75 3 associated associate VBN cord-307853-m1q1sjr4 75 4 with with IN cord-307853-m1q1sjr4 75 5 a a DT cord-307853-m1q1sjr4 75 6 given give VBN cord-307853-m1q1sjr4 75 7 normal normal JJ cord-307853-m1q1sjr4 75 8 mode mode NN cord-307853-m1q1sjr4 75 9 is be VBZ cord-307853-m1q1sjr4 75 10 directly directly RB cord-307853-m1q1sjr4 75 11 proportional proportional JJ cord-307853-m1q1sjr4 75 12 to to IN cord-307853-m1q1sjr4 75 13 its -PRON- PRP$ cord-307853-m1q1sjr4 75 14 eigenvalue eigenvalue NN cord-307853-m1q1sjr4 75 15 [ [ -LRB- cord-307853-m1q1sjr4 75 16 28 28 CD cord-307853-m1q1sjr4 75 17 ] ] -RRB- cord-307853-m1q1sjr4 75 18 . . . cord-307853-m1q1sjr4 76 1 We -PRON- PRP cord-307853-m1q1sjr4 76 2 have have VBP cord-307853-m1q1sjr4 76 3 discarded discard VBN cord-307853-m1q1sjr4 77 1 the the DT cord-307853-m1q1sjr4 77 2 _SP cord-307853-m1q1sjr4 77 3 We -PRON- PRP cord-307853-m1q1sjr4 77 4 have have VBP cord-307853-m1q1sjr4 77 5 assessed assess VBN cord-307853-m1q1sjr4 77 6 the the DT cord-307853-m1q1sjr4 77 7 extent extent NN cord-307853-m1q1sjr4 77 8 to to TO cord-307853-m1q1sjr4 77 9 which which WDT cord-307853-m1q1sjr4 77 10 the the DT cord-307853-m1q1sjr4 77 11 trimer trimer NN cord-307853-m1q1sjr4 77 12 conformation conformation NN cord-307853-m1q1sjr4 77 13 influences influence VBZ cord-307853-m1q1sjr4 77 14 the the DT cord-307853-m1q1sjr4 77 15 dynamics dynamic NNS cord-307853-m1q1sjr4 77 16 of of IN cord-307853-m1q1sjr4 77 17 each each DT cord-307853-m1q1sjr4 77 18 S S NNP cord-307853-m1q1sjr4 77 19 protein protein NN cord-307853-m1q1sjr4 77 20 chain chain NN cord-307853-m1q1sjr4 77 21 ( ( -LRB- cord-307853-m1q1sjr4 77 22 Fig Fig NNP cord-307853-m1q1sjr4 77 23 . . . cord-307853-m1q1sjr4 77 24 3 3 CD cord-307853-m1q1sjr4 77 25 ) ) -RRB- cord-307853-m1q1sjr4 77 26 . . . cord-307853-m1q1sjr4 78 1 Overall overall RB cord-307853-m1q1sjr4 78 2 the the DT cord-307853-m1q1sjr4 78 3 pattern pattern NN cord-307853-m1q1sjr4 78 4 of of IN cord-307853-m1q1sjr4 78 5 the the DT cord-307853-m1q1sjr4 78 6 cross cross NN cord-307853-m1q1sjr4 78 7 correlation correlation NN cord-307853-m1q1sjr4 78 8 matrix matrix NN cord-307853-m1q1sjr4 78 9 ( ( -LRB- cord-307853-m1q1sjr4 78 10 CCM CCM NNP cord-307853-m1q1sjr4 78 11 ) ) -RRB- cord-307853-m1q1sjr4 78 12 looks look VBZ cord-307853-m1q1sjr4 78 13 similar similar JJ cord-307853-m1q1sjr4 78 14 for for IN cord-307853-m1q1sjr4 78 15 three three CD cord-307853-m1q1sjr4 78 16 models model NNS cord-307853-m1q1sjr4 78 17 and and CC cord-307853-m1q1sjr4 78 18 have have VBP cord-307853-m1q1sjr4 78 19 similar similar JJ cord-307853-m1q1sjr4 78 20 domain domain NN cord-307853-m1q1sjr4 78 21 wise wise JJ cord-307853-m1q1sjr4 78 22 correlated correlate VBN cord-307853-m1q1sjr4 78 23 movement movement NN cord-307853-m1q1sjr4 78 24 but but CC cord-307853-m1q1sjr4 78 25 the the DT cord-307853-m1q1sjr4 78 26 magnitude magnitude NN cord-307853-m1q1sjr4 78 27 of of IN cord-307853-m1q1sjr4 78 28 correlation correlation NN cord-307853-m1q1sjr4 78 29 coefficients coefficient NNS cord-307853-m1q1sjr4 78 30 ( ( -LRB- cord-307853-m1q1sjr4 78 31 CC CC NNP cord-307853-m1q1sjr4 78 32 ) ) -RRB- cord-307853-m1q1sjr4 78 33 are be VBP cord-307853-m1q1sjr4 78 34 different different JJ cord-307853-m1q1sjr4 78 35 to to IN cord-307853-m1q1sjr4 78 36 some some DT cord-307853-m1q1sjr4 78 37 extent extent NN cord-307853-m1q1sjr4 78 38 . . . cord-307853-m1q1sjr4 79 1 According accord VBG cord-307853-m1q1sjr4 79 2 to to IN cord-307853-m1q1sjr4 79 3 PDB PDB NNP cord-307853-m1q1sjr4 79 4 and and CC cord-307853-m1q1sjr4 79 5 Uniprot Uniprot NNP cord-307853-m1q1sjr4 79 6 protein protein NN cord-307853-m1q1sjr4 79 7 feature feature NN cord-307853-m1q1sjr4 79 8 view view NN cord-307853-m1q1sjr4 79 9 , , , cord-307853-m1q1sjr4 79 10 the the DT cord-307853-m1q1sjr4 79 11 position position NN cord-307853-m1q1sjr4 79 12 of of IN cord-307853-m1q1sjr4 79 13 S1 S1 NNP cord-307853-m1q1sjr4 79 14 NTD NTD NNP cord-307853-m1q1sjr4 79 15 , , , cord-307853-m1q1sjr4 79 16 S1 S1 NNP cord-307853-m1q1sjr4 79 17 CTD CTD NNP cord-307853-m1q1sjr4 79 18 and and CC cord-307853-m1q1sjr4 79 19 RBD RBD NNP cord-307853-m1q1sjr4 79 20 for for IN cord-307853-m1q1sjr4 79 21 the the DT cord-307853-m1q1sjr4 79 22 protein protein NN cord-307853-m1q1sjr4 79 23 models model NNS cord-307853-m1q1sjr4 79 24 are be VBP cord-307853-m1q1sjr4 79 25 as as IN cord-307853-m1q1sjr4 79 26 follows follow VBZ cord-307853-m1q1sjr4 79 27 : : : cord-307853-m1q1sjr4 80 1 SARS SARS NNP cord-307853-m1q1sjr4 80 2 - - HYPH cord-307853-m1q1sjr4 80 3 CoV CoV NNP cord-307853-m1q1sjr4 80 4 : : : cord-307853-m1q1sjr4 80 5 14 14 CD cord-307853-m1q1sjr4 80 6 - - SYM cord-307853-m1q1sjr4 80 7 290 290 CD cord-307853-m1q1sjr4 80 8 is be VBZ cord-307853-m1q1sjr4 80 9 S1 S1 NNP cord-307853-m1q1sjr4 80 10 NTD NTD NNP cord-307853-m1q1sjr4 80 11 ( ( -LRB- cord-307853-m1q1sjr4 80 12 N n CD cord-307853-m1q1sjr4 80 13 - - HYPH cord-307853-m1q1sjr4 80 14 terminal terminal NN cord-307853-m1q1sjr4 80 15 domain domain NN cord-307853-m1q1sjr4 80 16 ) ) -RRB- cord-307853-m1q1sjr4 80 17 , , , cord-307853-m1q1sjr4 80 18 321 321 CD cord-307853-m1q1sjr4 80 19 - - SYM cord-307853-m1q1sjr4 80 20 513 513 CD cord-307853-m1q1sjr4 80 21 is be VBZ cord-307853-m1q1sjr4 80 22 S1 S1 NNP cord-307853-m1q1sjr4 80 23 CTD CTD NNP cord-307853-m1q1sjr4 80 24 ( ( -LRB- cord-307853-m1q1sjr4 80 25 C C NNP cord-307853-m1q1sjr4 80 26 terminal terminal NN cord-307853-m1q1sjr4 80 27 domain domain NN cord-307853-m1q1sjr4 80 28 ) ) -RRB- cord-307853-m1q1sjr4 80 29 , , . cord-307853-m1q1sjr4 81 1 306 306 LS cord-307853-m1q1sjr4 81 2 - - SYM cord-307853-m1q1sjr4 81 3 527 527 CD cord-307853-m1q1sjr4 81 4 is be VBZ cord-307853-m1q1sjr4 81 5 RBD RBD NNP cord-307853-m1q1sjr4 81 6 ( ( -LRB- cord-307853-m1q1sjr4 81 7 binding bind VBG cord-307853-m1q1sjr4 81 8 motif motif NN cord-307853-m1q1sjr4 81 9 is be VBZ cord-307853-m1q1sjr4 81 10 424 424 CD cord-307853-m1q1sjr4 81 11 - - SYM cord-307853-m1q1sjr4 81 12 494 494 CD cord-307853-m1q1sjr4 81 13 ) ) -RRB- cord-307853-m1q1sjr4 81 14 ; ; : cord-307853-m1q1sjr4 81 15 SARS SARS NNP cord-307853-m1q1sjr4 81 16 - - HYPH cord-307853-m1q1sjr4 81 17 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 81 18 : : : cord-307853-m1q1sjr4 81 19 13 13 CD cord-307853-m1q1sjr4 81 20 - - SYM cord-307853-m1q1sjr4 81 21 303 303 CD cord-307853-m1q1sjr4 81 22 is be VBZ cord-307853-m1q1sjr4 81 23 S1 S1 NNP cord-307853-m1q1sjr4 81 24 NTD NTD NNP cord-307853-m1q1sjr4 81 25 , , , cord-307853-m1q1sjr4 81 26 334 334 CD cord-307853-m1q1sjr4 81 27 - - HYPH cord-307853-m1q1sjr4 81 28 527 527 CD cord-307853-m1q1sjr4 82 1 is be VBZ cord-307853-m1q1sjr4 82 2 S1 S1 NNP cord-307853-m1q1sjr4 82 3 CTD CTD NNP cord-307853-m1q1sjr4 82 4 , , , cord-307853-m1q1sjr4 82 5 319 319 CD cord-307853-m1q1sjr4 82 6 - - SYM cord-307853-m1q1sjr4 82 7 541 541 CD cord-307853-m1q1sjr4 83 1 is be VBZ cord-307853-m1q1sjr4 83 2 RBD RBD NNP cord-307853-m1q1sjr4 83 3 ( ( -LRB- cord-307853-m1q1sjr4 83 4 binding bind VBG cord-307853-m1q1sjr4 83 5 motif motif NN cord-307853-m1q1sjr4 83 6 is be VBZ cord-307853-m1q1sjr4 83 7 437 437 CD cord-307853-m1q1sjr4 83 8 - - SYM cord-307853-m1q1sjr4 83 9 508 508 CD cord-307853-m1q1sjr4 83 10 ) ) -RRB- cord-307853-m1q1sjr4 83 11 ; ; : cord-307853-m1q1sjr4 83 12 MERS MERS NNP cord-307853-m1q1sjr4 83 13 - - HYPH cord-307853-m1q1sjr4 83 14 CoV CoV NNP cord-307853-m1q1sjr4 83 15 : : : cord-307853-m1q1sjr4 83 16 18 18 CD cord-307853-m1q1sjr4 83 17 - - SYM cord-307853-m1q1sjr4 83 18 350 350 CD cord-307853-m1q1sjr4 83 19 is be VBZ cord-307853-m1q1sjr4 83 20 S1 S1 NNP cord-307853-m1q1sjr4 83 21 NTD NTD NNP cord-307853-m1q1sjr4 83 22 , , , cord-307853-m1q1sjr4 83 23 381 381 CD cord-307853-m1q1sjr4 83 24 - - SYM cord-307853-m1q1sjr4 83 25 588 588 CD cord-307853-m1q1sjr4 83 26 is be VBZ cord-307853-m1q1sjr4 84 1 J J NNP cord-307853-m1q1sjr4 84 2 o o NN cord-307853-m1q1sjr4 84 3 u u NN cord-307853-m1q1sjr4 84 4 r r NN cord-307853-m1q1sjr4 84 5 n n NN cord-307853-m1q1sjr4 84 6 a a DT cord-307853-m1q1sjr4 84 7 l l NN cord-307853-m1q1sjr4 84 8 P p NN cord-307853-m1q1sjr4 84 9 r r NN cord-307853-m1q1sjr4 84 10 e e NN cord-307853-m1q1sjr4 84 11 -p -p NN cord-307853-m1q1sjr4 84 12 r r NN cord-307853-m1q1sjr4 84 13 o o NN cord-307853-m1q1sjr4 85 1 o o UH cord-307853-m1q1sjr4 85 2 f f NN cord-307853-m1q1sjr4 85 3 spike spike NN cord-307853-m1q1sjr4 85 4 proteins protein NNS cord-307853-m1q1sjr4 85 5 are be VBP cord-307853-m1q1sjr4 85 6 shown show VBN cord-307853-m1q1sjr4 85 7 . . . cord-307853-m1q1sjr4 86 1 Color color NN cord-307853-m1q1sjr4 86 2 coding coding NN cord-307853-m1q1sjr4 86 3 is be VBZ cord-307853-m1q1sjr4 86 4 as as IN cord-307853-m1q1sjr4 86 5 follows follow VBZ cord-307853-m1q1sjr4 86 6 : : : cord-307853-m1q1sjr4 87 1 Orange orange NN cord-307853-m1q1sjr4 87 2 : : : cord-307853-m1q1sjr4 87 3 S1 S1 NNP cord-307853-m1q1sjr4 87 4 NTD NTD NNP cord-307853-m1q1sjr4 87 5 , , , cord-307853-m1q1sjr4 87 6 Violet violet NN cord-307853-m1q1sjr4 87 7 : : : cord-307853-m1q1sjr4 87 8 S1 S1 NNP cord-307853-m1q1sjr4 87 9 CTD CTD NNP cord-307853-m1q1sjr4 87 10 , , , cord-307853-m1q1sjr4 87 11 Cyan Cyan NNP cord-307853-m1q1sjr4 87 12 : : : cord-307853-m1q1sjr4 87 13 S2 s2 NN cord-307853-m1q1sjr4 87 14 region region NN cord-307853-m1q1sjr4 87 15 and and CC cord-307853-m1q1sjr4 87 16 Blue Blue NNP cord-307853-m1q1sjr4 87 17 : : : cord-307853-m1q1sjr4 87 18 RBD RBD NNP cord-307853-m1q1sjr4 87 19 . . . cord-307853-m1q1sjr4 88 1 Multiple multiple JJ cord-307853-m1q1sjr4 88 2 sequence sequence NN cord-307853-m1q1sjr4 88 3 alignment alignment NN cord-307853-m1q1sjr4 88 4 of of IN cord-307853-m1q1sjr4 88 5 the the DT cord-307853-m1q1sjr4 88 6 proteins protein NNS cord-307853-m1q1sjr4 88 7 is be VBZ cord-307853-m1q1sjr4 88 8 given give VBN cord-307853-m1q1sjr4 88 9 in in IN cord-307853-m1q1sjr4 88 10 supplementary supplementary JJ cord-307853-m1q1sjr4 88 11 . . . cord-307853-m1q1sjr4 89 1 Emphasizing emphasize VBG cord-307853-m1q1sjr4 89 2 the the DT cord-307853-m1q1sjr4 89 3 motions motion NNS cord-307853-m1q1sjr4 89 4 among among IN cord-307853-m1q1sjr4 89 5 the the DT cord-307853-m1q1sjr4 89 6 domains domain NNS cord-307853-m1q1sjr4 89 7 , , , cord-307853-m1q1sjr4 89 8 it -PRON- PRP cord-307853-m1q1sjr4 89 9 was be VBD cord-307853-m1q1sjr4 89 10 found find VBN cord-307853-m1q1sjr4 89 11 that that IN cord-307853-m1q1sjr4 89 12 SARS SARS NNP cord-307853-m1q1sjr4 89 13 - - HYPH cord-307853-m1q1sjr4 89 14 CoV CoV NNP cord-307853-m1q1sjr4 89 15 and and CC cord-307853-m1q1sjr4 89 16 SARS SARS NNP cord-307853-m1q1sjr4 89 17 - - HYPH cord-307853-m1q1sjr4 89 18 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 89 19 S S NNP cord-307853-m1q1sjr4 89 20 proteins protein NNS cord-307853-m1q1sjr4 89 21 have have VBP cord-307853-m1q1sjr4 89 22 homogenous homogenous JJ cord-307853-m1q1sjr4 89 23 correlated correlate VBN cord-307853-m1q1sjr4 89 24 displacements displacement NNS cord-307853-m1q1sjr4 89 25 . . . cord-307853-m1q1sjr4 90 1 S1 S1 NNP cord-307853-m1q1sjr4 90 2 CTD CTD NNP cord-307853-m1q1sjr4 90 3 and and CC cord-307853-m1q1sjr4 90 4 NTD NTD NNP cord-307853-m1q1sjr4 90 5 of of IN cord-307853-m1q1sjr4 90 6 each each DT cord-307853-m1q1sjr4 90 7 chain chain NN cord-307853-m1q1sjr4 90 8 have have VBP cord-307853-m1q1sjr4 90 9 weak weak JJ cord-307853-m1q1sjr4 90 10 negative negative JJ cord-307853-m1q1sjr4 90 11 correlation correlation NN cord-307853-m1q1sjr4 90 12 with with IN cord-307853-m1q1sjr4 90 13 each each DT cord-307853-m1q1sjr4 90 14 other other JJ cord-307853-m1q1sjr4 90 15 ( ( -LRB- cord-307853-m1q1sjr4 90 16 -0.1 -0.1 CD cord-307853-m1q1sjr4 90 17 to to IN cord-307853-m1q1sjr4 90 18 -0.4 -0.4 CD cord-307853-m1q1sjr4 90 19 ) ) -RRB- cord-307853-m1q1sjr4 90 20 . . . cord-307853-m1q1sjr4 91 1 S1 S1 NNP cord-307853-m1q1sjr4 91 2 CTD CTD NNP cord-307853-m1q1sjr4 91 3 of of IN cord-307853-m1q1sjr4 91 4 one one CD cord-307853-m1q1sjr4 91 5 chain chain NN cord-307853-m1q1sjr4 91 6 has have VBZ cord-307853-m1q1sjr4 91 7 weak weak JJ cord-307853-m1q1sjr4 91 8 negative negative JJ cord-307853-m1q1sjr4 91 9 correlation correlation NN cord-307853-m1q1sjr4 91 10 with with IN cord-307853-m1q1sjr4 91 11 CTD CTD NNP cord-307853-m1q1sjr4 91 12 of of IN cord-307853-m1q1sjr4 91 13 other other JJ cord-307853-m1q1sjr4 91 14 chains chain NNS cord-307853-m1q1sjr4 91 15 and and CC cord-307853-m1q1sjr4 91 16 same same JJ cord-307853-m1q1sjr4 91 17 scenario scenario NN cord-307853-m1q1sjr4 91 18 is be VBZ cord-307853-m1q1sjr4 91 19 seen see VBN cord-307853-m1q1sjr4 91 20 with with IN cord-307853-m1q1sjr4 91 21 the the DT cord-307853-m1q1sjr4 91 22 NTD NTD NNP cord-307853-m1q1sjr4 91 23 . . . cord-307853-m1q1sjr4 92 1 S1 S1 NNP cord-307853-m1q1sjr4 92 2 CTD CTD NNP cord-307853-m1q1sjr4 92 3 and and CC cord-307853-m1q1sjr4 92 4 NTD NTD NNP cord-307853-m1q1sjr4 92 5 in in IN cord-307853-m1q1sjr4 92 6 each each DT cord-307853-m1q1sjr4 92 7 chain chain NN cord-307853-m1q1sjr4 92 8 are be VBP cord-307853-m1q1sjr4 92 9 negatively negatively RB cord-307853-m1q1sjr4 92 10 correlated correlate VBN cord-307853-m1q1sjr4 92 11 with with IN cord-307853-m1q1sjr4 92 12 each each DT cord-307853-m1q1sjr4 92 13 other other JJ cord-307853-m1q1sjr4 92 14 implying imply VBG cord-307853-m1q1sjr4 92 15 the the DT cord-307853-m1q1sjr4 92 16 RBM RBM NNP cord-307853-m1q1sjr4 92 17 tries try VBZ cord-307853-m1q1sjr4 92 18 to to TO cord-307853-m1q1sjr4 92 19 move move VB cord-307853-m1q1sjr4 92 20 further further RB cord-307853-m1q1sjr4 92 21 from from IN cord-307853-m1q1sjr4 92 22 NTD NTD NNP cord-307853-m1q1sjr4 92 23 in in IN cord-307853-m1q1sjr4 92 24 order order NN cord-307853-m1q1sjr4 92 25 to to TO cord-307853-m1q1sjr4 92 26 be be VB cord-307853-m1q1sjr4 92 27 accessible accessible JJ cord-307853-m1q1sjr4 92 28 by by IN cord-307853-m1q1sjr4 92 29 the the DT cord-307853-m1q1sjr4 92 30 receptor receptor NN cord-307853-m1q1sjr4 92 31 . . . cord-307853-m1q1sjr4 93 1 One one CD cord-307853-m1q1sjr4 93 2 of of IN cord-307853-m1q1sjr4 93 3 the the DT cord-307853-m1q1sjr4 93 4 interesting interesting JJ cord-307853-m1q1sjr4 93 5 facts fact NNS cord-307853-m1q1sjr4 93 6 is be VBZ cord-307853-m1q1sjr4 93 7 that that IN cord-307853-m1q1sjr4 93 8 S1 S1 NNP cord-307853-m1q1sjr4 93 9 NTD NTD NNP cord-307853-m1q1sjr4 93 10 of of IN cord-307853-m1q1sjr4 93 11 one one CD cord-307853-m1q1sjr4 93 12 chain chain NN cord-307853-m1q1sjr4 93 13 shows show VBZ cord-307853-m1q1sjr4 93 14 strong strong JJ cord-307853-m1q1sjr4 93 15 positive positive JJ cord-307853-m1q1sjr4 93 16 correlation correlation NN cord-307853-m1q1sjr4 93 17 with with IN cord-307853-m1q1sjr4 93 18 CTD CTD NNP cord-307853-m1q1sjr4 93 19 of of IN cord-307853-m1q1sjr4 93 20 at at RB cord-307853-m1q1sjr4 93 21 least least RBS cord-307853-m1q1sjr4 93 22 one one CD cord-307853-m1q1sjr4 93 23 of of IN cord-307853-m1q1sjr4 93 24 the the DT cord-307853-m1q1sjr4 93 25 two two CD cord-307853-m1q1sjr4 93 26 other other JJ cord-307853-m1q1sjr4 93 27 chains chain NNS cord-307853-m1q1sjr4 93 28 which which WDT cord-307853-m1q1sjr4 93 29 is be VBZ cord-307853-m1q1sjr4 93 30 true true JJ cord-307853-m1q1sjr4 93 31 for for IN cord-307853-m1q1sjr4 93 32 both both DT cord-307853-m1q1sjr4 93 33 SARS SARS NNP cord-307853-m1q1sjr4 93 34 - - HYPH cord-307853-m1q1sjr4 93 35 CoV CoV NNP cord-307853-m1q1sjr4 93 36 and and CC cord-307853-m1q1sjr4 93 37 SARS SARS NNP cord-307853-m1q1sjr4 93 38 - - HYPH cord-307853-m1q1sjr4 93 39 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 93 40 S S NNP cord-307853-m1q1sjr4 93 41 protein protein NN cord-307853-m1q1sjr4 93 42 but but CC cord-307853-m1q1sjr4 93 43 variation variation NN cord-307853-m1q1sjr4 93 44 is be VBZ cord-307853-m1q1sjr4 93 45 seen see VBN cord-307853-m1q1sjr4 93 46 in in IN cord-307853-m1q1sjr4 93 47 the the DT cord-307853-m1q1sjr4 93 48 CCM CCM NNS cord-307853-m1q1sjr4 93 49 of of IN cord-307853-m1q1sjr4 93 50 MERS MERS NNP cord-307853-m1q1sjr4 93 51 - - HYPH cord-307853-m1q1sjr4 93 52 CoV CoV NNP cord-307853-m1q1sjr4 93 53 S S NNP cord-307853-m1q1sjr4 93 54 protein protein NN cord-307853-m1q1sjr4 93 55 ( ( -LRB- cord-307853-m1q1sjr4 93 56 Fig Fig NNP cord-307853-m1q1sjr4 93 57 . . . cord-307853-m1q1sjr4 93 58 3C 3C NNP cord-307853-m1q1sjr4 93 59 ) ) -RRB- cord-307853-m1q1sjr4 93 60 . . . cord-307853-m1q1sjr4 94 1 S1 S1 NNP cord-307853-m1q1sjr4 94 2 NTD NTD NNP cord-307853-m1q1sjr4 94 3 of of IN cord-307853-m1q1sjr4 94 4 each each DT cord-307853-m1q1sjr4 94 5 chain chain NN cord-307853-m1q1sjr4 94 6 is be VBZ cord-307853-m1q1sjr4 94 7 negatively negatively RB cord-307853-m1q1sjr4 94 8 correlated correlate VBN cord-307853-m1q1sjr4 94 9 with with IN cord-307853-m1q1sjr4 94 10 NTD NTD NNP cord-307853-m1q1sjr4 94 11 of of IN cord-307853-m1q1sjr4 94 12 other other JJ cord-307853-m1q1sjr4 94 13 chains chain NNS cord-307853-m1q1sjr4 94 14 with with IN cord-307853-m1q1sjr4 94 15 magnitude magnitude NN cord-307853-m1q1sjr4 94 16 range range NN cord-307853-m1q1sjr4 94 17 -0 -0 NNP cord-307853-m1q1sjr4 94 18 . . . cord-307853-m1q1sjr4 95 1 around around IN cord-307853-m1q1sjr4 95 2 the the DT cord-307853-m1q1sjr4 95 3 interfaces interface NNS cord-307853-m1q1sjr4 95 4 of of IN cord-307853-m1q1sjr4 95 5 domains domain NNS cord-307853-m1q1sjr4 95 6 [ [ -LRB- cord-307853-m1q1sjr4 95 7 32 32 CD cord-307853-m1q1sjr4 95 8 ] ] -RRB- cord-307853-m1q1sjr4 95 9 . . . cord-307853-m1q1sjr4 96 1 In in IN cord-307853-m1q1sjr4 96 2 order order NN cord-307853-m1q1sjr4 96 3 to to TO cord-307853-m1q1sjr4 96 4 comprehensibly comprehensibly RB cord-307853-m1q1sjr4 96 5 describe describe VB cord-307853-m1q1sjr4 96 6 the the DT cord-307853-m1q1sjr4 96 7 motion motion NN cord-307853-m1q1sjr4 96 8 of of IN cord-307853-m1q1sjr4 96 9 the the DT cord-307853-m1q1sjr4 96 10 trimer trimer NN cord-307853-m1q1sjr4 96 11 chains chain NNS cord-307853-m1q1sjr4 96 12 of of IN cord-307853-m1q1sjr4 96 13 the the DT cord-307853-m1q1sjr4 96 14 first first JJ cord-307853-m1q1sjr4 96 15 four four CD cord-307853-m1q1sjr4 96 16 low low JJ cord-307853-m1q1sjr4 96 17 frequency frequency NN cord-307853-m1q1sjr4 96 18 ( ( -LRB- cord-307853-m1q1sjr4 96 19 low low JJ cord-307853-m1q1sjr4 96 20 eigenvalue eigenvalue NN cord-307853-m1q1sjr4 96 21 ) ) -RRB- cord-307853-m1q1sjr4 96 22 modes mode NNS cord-307853-m1q1sjr4 96 23 ( ( -LRB- cord-307853-m1q1sjr4 96 24 λ7 λ7 NNP cord-307853-m1q1sjr4 96 25 , , , cord-307853-m1q1sjr4 96 26 λ8 λ8 NN cord-307853-m1q1sjr4 96 27 , , , cord-307853-m1q1sjr4 96 28 λ9 λ9 NNP cord-307853-m1q1sjr4 96 29 , , , cord-307853-m1q1sjr4 96 30 λ10 λ10 NN cord-307853-m1q1sjr4 96 31 ) ) -RRB- cord-307853-m1q1sjr4 96 32 , , , cord-307853-m1q1sjr4 96 33 first first RB cord-307853-m1q1sjr4 96 34 we -PRON- PRP cord-307853-m1q1sjr4 96 35 have have VBP cord-307853-m1q1sjr4 96 36 computed compute VBN cord-307853-m1q1sjr4 96 37 three three CD cord-307853-m1q1sjr4 96 38 unique unique JJ cord-307853-m1q1sjr4 96 39 symmetry symmetry NN cord-307853-m1q1sjr4 96 40 axis axis NN cord-307853-m1q1sjr4 96 41 of of IN cord-307853-m1q1sjr4 96 42 the the DT cord-307853-m1q1sjr4 96 43 spike spike NN cord-307853-m1q1sjr4 96 44 trimer trimer NN cord-307853-m1q1sjr4 96 45 using use VBG cord-307853-m1q1sjr4 96 46 VMD VMD NNP cord-307853-m1q1sjr4 96 47 Symmetry Symmetry NNP cord-307853-m1q1sjr4 96 48 Tool Tool NNP cord-307853-m1q1sjr4 96 49 . . . cord-307853-m1q1sjr4 97 1 Among among IN cord-307853-m1q1sjr4 97 2 the the DT cord-307853-m1q1sjr4 97 3 three three CD cord-307853-m1q1sjr4 97 4 symmetry symmetry NN cord-307853-m1q1sjr4 97 5 axis axis NN cord-307853-m1q1sjr4 97 6 , , , cord-307853-m1q1sjr4 97 7 one one CD cord-307853-m1q1sjr4 97 8 pointed point VBD cord-307853-m1q1sjr4 97 9 outward outward RB cord-307853-m1q1sjr4 97 10 through through IN cord-307853-m1q1sjr4 97 11 the the DT cord-307853-m1q1sjr4 97 12 trimer trimer NN cord-307853-m1q1sjr4 97 13 core core NN cord-307853-m1q1sjr4 97 14 , , , cord-307853-m1q1sjr4 97 15 which which WDT cord-307853-m1q1sjr4 97 16 we -PRON- PRP cord-307853-m1q1sjr4 97 17 have have VBP cord-307853-m1q1sjr4 97 18 named name VBN cord-307853-m1q1sjr4 97 19 the the DT cord-307853-m1q1sjr4 97 20 Z z NN cord-307853-m1q1sjr4 97 21 axis axis NN cord-307853-m1q1sjr4 97 22 ( ( -LRB- cord-307853-m1q1sjr4 97 23 default default NN cord-307853-m1q1sjr4 97 24 2 2 CD cord-307853-m1q1sjr4 97 25 in in IN cord-307853-m1q1sjr4 97 26 VMD VMD NNP cord-307853-m1q1sjr4 97 27 nomenclature nomenclature NN cord-307853-m1q1sjr4 97 28 ) ) -RRB- cord-307853-m1q1sjr4 97 29 and and CC cord-307853-m1q1sjr4 97 30 the the DT cord-307853-m1q1sjr4 97 31 other other JJ cord-307853-m1q1sjr4 97 32 two two CD cord-307853-m1q1sjr4 97 33 axis axis NN cord-307853-m1q1sjr4 97 34 were be VBD cord-307853-m1q1sjr4 97 35 named name VBN cord-307853-m1q1sjr4 97 36 as as IN cord-307853-m1q1sjr4 97 37 X X NNP cord-307853-m1q1sjr4 97 38 and and CC cord-307853-m1q1sjr4 97 39 Y Y NNP cord-307853-m1q1sjr4 97 40 axis axis NN cord-307853-m1q1sjr4 97 41 ( ( -LRB- cord-307853-m1q1sjr4 97 42 default default NN cord-307853-m1q1sjr4 97 43 VMD VMD NNP cord-307853-m1q1sjr4 97 44 nomenclature nomenclature NN cord-307853-m1q1sjr4 97 45 1 1 CD cord-307853-m1q1sjr4 97 46 and and CC cord-307853-m1q1sjr4 97 47 0 0 CD cord-307853-m1q1sjr4 97 48 respectively respectively RB cord-307853-m1q1sjr4 97 49 ) ) -RRB- cord-307853-m1q1sjr4 97 50 . . . cord-307853-m1q1sjr4 98 1 We -PRON- PRP cord-307853-m1q1sjr4 98 2 have have VBP cord-307853-m1q1sjr4 98 3 used use VBN cord-307853-m1q1sjr4 98 4 default default NN cord-307853-m1q1sjr4 98 5 PDB PDB NNP cord-307853-m1q1sjr4 98 6 chain chain NN cord-307853-m1q1sjr4 98 7 ids id NNS cord-307853-m1q1sjr4 98 8 of of IN cord-307853-m1q1sjr4 98 9 the the DT cord-307853-m1q1sjr4 98 10 three three CD cord-307853-m1q1sjr4 98 11 spike spike NN cord-307853-m1q1sjr4 98 12 protein protein NN cord-307853-m1q1sjr4 98 13 structures structure NNS cord-307853-m1q1sjr4 98 14 to to TO cord-307853-m1q1sjr4 98 15 address address VB cord-307853-m1q1sjr4 98 16 the the DT cord-307853-m1q1sjr4 98 17 chain chain NN cord-307853-m1q1sjr4 98 18 and and CC cord-307853-m1q1sjr4 98 19 trimer trimer NN cord-307853-m1q1sjr4 98 20 motion motion NN cord-307853-m1q1sjr4 98 21 individually individually RB cord-307853-m1q1sjr4 98 22 . . . cord-307853-m1q1sjr4 99 1 As as IN cord-307853-m1q1sjr4 99 2 previously previously RB cord-307853-m1q1sjr4 99 3 described describe VBN cord-307853-m1q1sjr4 99 4 we -PRON- PRP cord-307853-m1q1sjr4 99 5 will will MD cord-307853-m1q1sjr4 99 6 confined confined VB cord-307853-m1q1sjr4 99 7 ourselves -PRON- PRP cord-307853-m1q1sjr4 99 8 to to TO cord-307853-m1q1sjr4 99 9 discuss discuss VB cord-307853-m1q1sjr4 99 10 the the DT cord-307853-m1q1sjr4 99 11 motion motion NN cord-307853-m1q1sjr4 99 12 of of IN cord-307853-m1q1sjr4 99 13 S1 S1 NNP cord-307853-m1q1sjr4 99 14 domain domain NN cord-307853-m1q1sjr4 99 15 of of IN cord-307853-m1q1sjr4 99 16 the the DT cord-307853-m1q1sjr4 99 17 three three CD cord-307853-m1q1sjr4 99 18 chains chain NNS cord-307853-m1q1sjr4 99 19 as as IN cord-307853-m1q1sjr4 99 20 it -PRON- PRP cord-307853-m1q1sjr4 99 21 harbors harbor VBZ cord-307853-m1q1sjr4 99 22 the the DT cord-307853-m1q1sjr4 99 23 functional functional JJ cord-307853-m1q1sjr4 99 24 receptor receptor NN cord-307853-m1q1sjr4 99 25 binding bind VBG cord-307853-m1q1sjr4 99 26 domain domain NN cord-307853-m1q1sjr4 99 27 . . . cord-307853-m1q1sjr4 100 1 In in IN cord-307853-m1q1sjr4 100 2 all all PDT cord-307853-m1q1sjr4 100 3 the the DT cord-307853-m1q1sjr4 100 4 structures structure NNS cord-307853-m1q1sjr4 100 5 , , , cord-307853-m1q1sjr4 100 6 the the DT cord-307853-m1q1sjr4 100 7 β β NN cord-307853-m1q1sjr4 100 8 - - HYPH cord-307853-m1q1sjr4 100 9 strand strand NN cord-307853-m1q1sjr4 100 10 region region NN cord-307853-m1q1sjr4 100 11 ( ( -LRB- cord-307853-m1q1sjr4 100 12 BSR BSR NNP cord-307853-m1q1sjr4 100 13 ) ) -RRB- cord-307853-m1q1sjr4 100 14 of of IN cord-307853-m1q1sjr4 100 15 S1 S1 NNP cord-307853-m1q1sjr4 100 16 dominates dominate VBZ cord-307853-m1q1sjr4 100 17 overall overall JJ cord-307853-m1q1sjr4 100 18 motions motion NNS cord-307853-m1q1sjr4 100 19 of of IN cord-307853-m1q1sjr4 100 20 the the DT cord-307853-m1q1sjr4 100 21 trimer trimer NN cord-307853-m1q1sjr4 100 22 in in IN cord-307853-m1q1sjr4 100 23 first first JJ cord-307853-m1q1sjr4 100 24 four four CD cord-307853-m1q1sjr4 100 25 low low JJ cord-307853-m1q1sjr4 100 26 frequency frequency NN cord-307853-m1q1sjr4 100 27 non non JJ cord-307853-m1q1sjr4 100 28 - - JJ cord-307853-m1q1sjr4 100 29 zero zero JJ cord-307853-m1q1sjr4 100 30 modes mode NNS cord-307853-m1q1sjr4 100 31 ( ( -LRB- cord-307853-m1q1sjr4 100 32 supplementary supplementary JJ cord-307853-m1q1sjr4 100 33 4 4 CD cord-307853-m1q1sjr4 100 34 , , , cord-307853-m1q1sjr4 100 35 5 5 CD cord-307853-m1q1sjr4 100 36 and and CC cord-307853-m1q1sjr4 100 37 6 6 CD cord-307853-m1q1sjr4 100 38 ) ) -RRB- cord-307853-m1q1sjr4 100 39 . . . cord-307853-m1q1sjr4 101 1 We -PRON- PRP cord-307853-m1q1sjr4 101 2 did do VBD cord-307853-m1q1sjr4 101 3 not not RB cord-307853-m1q1sjr4 101 4 notice notice VB cord-307853-m1q1sjr4 101 5 any any DT cord-307853-m1q1sjr4 101 6 concerted concerted JJ cord-307853-m1q1sjr4 101 7 motion motion NN cord-307853-m1q1sjr4 101 8 of of IN cord-307853-m1q1sjr4 101 9 the the DT cord-307853-m1q1sjr4 101 10 three three CD cord-307853-m1q1sjr4 101 11 chains chain NNS cord-307853-m1q1sjr4 101 12 _SP cord-307853-m1q1sjr4 102 1 We -PRON- PRP cord-307853-m1q1sjr4 102 2 have have VBP cord-307853-m1q1sjr4 102 3 computed compute VBN cord-307853-m1q1sjr4 102 4 the the DT cord-307853-m1q1sjr4 102 5 squared squared NNP cord-307853-m1q1sjr4 102 6 atomic atomic JJ cord-307853-m1q1sjr4 102 7 fluctuations fluctuation NNS cord-307853-m1q1sjr4 102 8 of of IN cord-307853-m1q1sjr4 102 9 the the DT cord-307853-m1q1sjr4 102 10 S S NNP cord-307853-m1q1sjr4 102 11 protein protein NN cord-307853-m1q1sjr4 102 12 models model NNS cord-307853-m1q1sjr4 102 13 using use VBG cord-307853-m1q1sjr4 102 14 first first RB cord-307853-m1q1sjr4 102 15 10 10 CD cord-307853-m1q1sjr4 102 16 nonzero nonzero JJ cord-307853-m1q1sjr4 102 17 normal normal JJ cord-307853-m1q1sjr4 102 18 modes mode NNS cord-307853-m1q1sjr4 102 19 ( ( -LRB- cord-307853-m1q1sjr4 102 20 Fig Fig NNP cord-307853-m1q1sjr4 102 21 . . . cord-307853-m1q1sjr4 102 22 6 6 CD cord-307853-m1q1sjr4 102 23 ) ) -RRB- cord-307853-m1q1sjr4 102 24 . . . cord-307853-m1q1sjr4 103 1 The the DT cord-307853-m1q1sjr4 103 2 amplitude amplitude NN cord-307853-m1q1sjr4 103 3 of of IN cord-307853-m1q1sjr4 103 4 the the DT cord-307853-m1q1sjr4 103 5 fluctuations fluctuation NNS cord-307853-m1q1sjr4 103 6 shows show VBZ cord-307853-m1q1sjr4 103 7 variation variation NN cord-307853-m1q1sjr4 103 8 within within IN cord-307853-m1q1sjr4 103 9 the the DT cord-307853-m1q1sjr4 103 10 models model NNS cord-307853-m1q1sjr4 103 11 . . . cord-307853-m1q1sjr4 104 1 In in IN cord-307853-m1q1sjr4 104 2 _SP cord-307853-m1q1sjr4 104 3 In in IN cord-307853-m1q1sjr4 104 4 order order NN cord-307853-m1q1sjr4 104 5 to to TO cord-307853-m1q1sjr4 104 6 compare compare VB cord-307853-m1q1sjr4 104 7 the the DT cord-307853-m1q1sjr4 104 8 normal normal JJ cord-307853-m1q1sjr4 104 9 modes mode NNS cord-307853-m1q1sjr4 104 10 between between IN cord-307853-m1q1sjr4 104 11 the the DT cord-307853-m1q1sjr4 104 12 structures structure NNS cord-307853-m1q1sjr4 104 13 , , , cord-307853-m1q1sjr4 104 14 we -PRON- PRP cord-307853-m1q1sjr4 104 15 have have VBP cord-307853-m1q1sjr4 104 16 calculated calculate VBN cord-307853-m1q1sjr4 104 17 the the DT cord-307853-m1q1sjr4 104 18 RMSIP RMSIP NNP cord-307853-m1q1sjr4 104 19 , , , cord-307853-m1q1sjr4 104 20 _SP cord-307853-m1q1sjr4 104 21 Normal normal JJ cord-307853-m1q1sjr4 104 22 mode mode NN cord-307853-m1q1sjr4 104 23 analysis analysis NN cord-307853-m1q1sjr4 104 24 of of IN cord-307853-m1q1sjr4 104 25 equilibrium equilibrium NN cord-307853-m1q1sjr4 104 26 structures structure NNS cord-307853-m1q1sjr4 104 27 falls fall VBZ cord-307853-m1q1sjr4 104 28 in in IN cord-307853-m1q1sjr4 104 29 the the DT cord-307853-m1q1sjr4 104 30 category category NN cord-307853-m1q1sjr4 104 31 of of IN cord-307853-m1q1sjr4 104 32 principal principal JJ cord-307853-m1q1sjr4 104 33 component component NN cord-307853-m1q1sjr4 104 34 analysis analysis NN cord-307853-m1q1sjr4 104 35 - - HYPH cord-307853-m1q1sjr4 104 36 based base VBN cord-307853-m1q1sjr4 104 37 methods method NNS cord-307853-m1q1sjr4 104 38 like like IN cord-307853-m1q1sjr4 104 39 singular singular JJ cord-307853-m1q1sjr4 104 40 value value NN cord-307853-m1q1sjr4 104 41 decomposition decomposition NN cord-307853-m1q1sjr4 104 42 of of IN cord-307853-m1q1sjr4 104 43 molecular molecular JJ cord-307853-m1q1sjr4 104 44 dynamics dynamic NNS cord-307853-m1q1sjr4 104 45 or or CC cord-307853-m1q1sjr4 104 46 Monte Monte NNP cord-307853-m1q1sjr4 104 47 Carlo Carlo NNP cord-307853-m1q1sjr4 104 48 trajectories trajectory NNS cord-307853-m1q1sjr4 104 49 or or CC cord-307853-m1q1sjr4 104 50 essential essential JJ cord-307853-m1q1sjr4 104 51 dynamics dynamic NNS cord-307853-m1q1sjr4 104 52 analysis analysis NN cord-307853-m1q1sjr4 104 53 of of IN cord-307853-m1q1sjr4 104 54 the the DT cord-307853-m1q1sjr4 104 55 covariance covariance NN cord-307853-m1q1sjr4 104 56 matrices matrix NNS cord-307853-m1q1sjr4 104 57 retrieved retrieve VBD cord-307853-m1q1sjr4 104 58 from from IN cord-307853-m1q1sjr4 104 59 MD MD NNP cord-307853-m1q1sjr4 104 60 runs run VBZ cord-307853-m1q1sjr4 104 61 [ [ -LRB- cord-307853-m1q1sjr4 104 62 20 20 CD cord-307853-m1q1sjr4 104 63 ] ] -RRB- cord-307853-m1q1sjr4 104 64 . . . cord-307853-m1q1sjr4 105 1 These these DT cord-307853-m1q1sjr4 105 2 studies study NNS cord-307853-m1q1sjr4 105 3 have have VBP cord-307853-m1q1sjr4 105 4 proven prove VBN cord-307853-m1q1sjr4 105 5 to to TO cord-307853-m1q1sjr4 105 6 be be VB cord-307853-m1q1sjr4 105 7 useful useful JJ cord-307853-m1q1sjr4 105 8 in in IN cord-307853-m1q1sjr4 105 9 studying study VBG cord-307853-m1q1sjr4 105 10 the the DT cord-307853-m1q1sjr4 105 11 equilibrium equilibrium NN cord-307853-m1q1sjr4 105 12 dynamics dynamic NNS cord-307853-m1q1sjr4 105 13 of of IN cord-307853-m1q1sjr4 105 14 proteins protein NNS cord-307853-m1q1sjr4 105 15 which which WDT cord-307853-m1q1sjr4 105 16 are be VBP cord-307853-m1q1sjr4 105 17 spanned span VBN cord-307853-m1q1sjr4 105 18 by by IN cord-307853-m1q1sjr4 105 19 low low JJ cord-307853-m1q1sjr4 105 20 frequency frequency NN cord-307853-m1q1sjr4 105 21 end end NN cord-307853-m1q1sjr4 105 22 of of IN cord-307853-m1q1sjr4 105 23 the the DT cord-307853-m1q1sjr4 105 24 mode mode NN cord-307853-m1q1sjr4 105 25 spectrum spectrum NN cord-307853-m1q1sjr4 105 26 [ [ -LRB- cord-307853-m1q1sjr4 105 27 33 33 CD cord-307853-m1q1sjr4 105 28 ] ] -RRB- cord-307853-m1q1sjr4 105 29 . . . cord-307853-m1q1sjr4 106 1 Anisotropic Anisotropic NNP cord-307853-m1q1sjr4 106 2 , , , cord-307853-m1q1sjr4 106 3 which which WDT cord-307853-m1q1sjr4 106 4 is be VBZ cord-307853-m1q1sjr4 106 5 proportional proportional JJ cord-307853-m1q1sjr4 106 6 to to IN cord-307853-m1q1sjr4 106 7 energy energy NN cord-307853-m1q1sjr4 106 8 , , , cord-307853-m1q1sjr4 106 9 will will MD cord-307853-m1q1sjr4 106 10 lead lead VB cord-307853-m1q1sjr4 106 11 to to IN cord-307853-m1q1sjr4 106 12 energetically energetically RB cord-307853-m1q1sjr4 106 13 unfavorable unfavorable JJ cord-307853-m1q1sjr4 106 14 motions motion NNS cord-307853-m1q1sjr4 106 15 [ [ -LRB- cord-307853-m1q1sjr4 106 16 20 20 CD cord-307853-m1q1sjr4 106 17 ] ] -RRB- cord-307853-m1q1sjr4 106 18 . . . cord-307853-m1q1sjr4 107 1 Spectra Spectra NNP cord-307853-m1q1sjr4 107 2 of of IN cord-307853-m1q1sjr4 107 3 eigenvalues eigenvalue NNS cord-307853-m1q1sjr4 107 4 shows show VBZ cord-307853-m1q1sjr4 107 5 that that IN cord-307853-m1q1sjr4 107 6 SARS SARS NNP cord-307853-m1q1sjr4 107 7 - - HYPH cord-307853-m1q1sjr4 107 8 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 107 9 S S NNP cord-307853-m1q1sjr4 107 10 has have VBZ cord-307853-m1q1sjr4 107 11 more more JJR cord-307853-m1q1sjr4 107 12 collective collective JJ cord-307853-m1q1sjr4 107 13 motion motion NN cord-307853-m1q1sjr4 107 14 than than IN cord-307853-m1q1sjr4 107 15 other other JJ cord-307853-m1q1sjr4 107 16 two two CD cord-307853-m1q1sjr4 107 17 S s NN cord-307853-m1q1sjr4 107 18 protein protein NN cord-307853-m1q1sjr4 107 19 implying imply VBG cord-307853-m1q1sjr4 108 1 SARS SARS NNP cord-307853-m1q1sjr4 108 2 - - HYPH cord-307853-m1q1sjr4 108 3 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 108 4 S S NNP cord-307853-m1q1sjr4 108 5 protein protein NN cord-307853-m1q1sjr4 108 6 has have VBZ cord-307853-m1q1sjr4 108 7 higher high JJR cord-307853-m1q1sjr4 108 8 stability stability NN cord-307853-m1q1sjr4 108 9 [ [ -LRB- cord-307853-m1q1sjr4 108 10 32 32 CD cord-307853-m1q1sjr4 108 11 ] ] -RRB- cord-307853-m1q1sjr4 108 12 and and CC cord-307853-m1q1sjr4 108 13 has have VBZ cord-307853-m1q1sjr4 108 14 lower low JJR cord-307853-m1q1sjr4 108 15 energetically energetically RB cord-307853-m1q1sjr4 108 16 expensive expensive JJ cord-307853-m1q1sjr4 108 17 motion motion NN cord-307853-m1q1sjr4 108 18 than than IN cord-307853-m1q1sjr4 108 19 the the DT cord-307853-m1q1sjr4 108 20 latter latter JJ cord-307853-m1q1sjr4 108 21 . . . cord-307853-m1q1sjr4 109 1 This this DT cord-307853-m1q1sjr4 109 2 stability stability NN cord-307853-m1q1sjr4 109 3 of of IN cord-307853-m1q1sjr4 109 4 the the DT cord-307853-m1q1sjr4 109 5 S S NNP cord-307853-m1q1sjr4 109 6 trimer trimer NN cord-307853-m1q1sjr4 109 7 of of IN cord-307853-m1q1sjr4 109 8 SARS SARS NNP cord-307853-m1q1sjr4 109 9 - - HYPH cord-307853-m1q1sjr4 109 10 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 109 11 in in IN cord-307853-m1q1sjr4 109 12 terms term NNS cord-307853-m1q1sjr4 109 13 of of IN cord-307853-m1q1sjr4 109 14 eigenvalue eigenvalue NN cord-307853-m1q1sjr4 109 15 frequency frequency NN cord-307853-m1q1sjr4 109 16 may may MD cord-307853-m1q1sjr4 109 17 give give VB cord-307853-m1q1sjr4 109 18 a a DT cord-307853-m1q1sjr4 109 19 part part NN cord-307853-m1q1sjr4 109 20 of of IN cord-307853-m1q1sjr4 109 21 the the DT cord-307853-m1q1sjr4 109 22 explanation explanation NN cord-307853-m1q1sjr4 109 23 about about IN cord-307853-m1q1sjr4 109 24 why why WRB cord-307853-m1q1sjr4 109 25 SARS SARS NNP cord-307853-m1q1sjr4 109 26 - - HYPH cord-307853-m1q1sjr4 109 27 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 109 28 is be VBZ cord-307853-m1q1sjr4 109 29 more more RBR cord-307853-m1q1sjr4 109 30 infective infective JJ cord-307853-m1q1sjr4 109 31 than than IN cord-307853-m1q1sjr4 109 32 other other JJ cord-307853-m1q1sjr4 109 33 two two CD cord-307853-m1q1sjr4 109 34 but but CC cord-307853-m1q1sjr4 109 35 do do VBP cord-307853-m1q1sjr4 109 36 not not RB cord-307853-m1q1sjr4 109 37 provide provide VB cord-307853-m1q1sjr4 109 38 detailed detailed JJ cord-307853-m1q1sjr4 109 39 description description NN cord-307853-m1q1sjr4 109 40 . . . cord-307853-m1q1sjr4 110 1 It -PRON- PRP cord-307853-m1q1sjr4 110 2 is be VBZ cord-307853-m1q1sjr4 110 3 shown show VBN cord-307853-m1q1sjr4 110 4 that that IN cord-307853-m1q1sjr4 110 5 in in IN cord-307853-m1q1sjr4 110 6 SARS SARS NNP cord-307853-m1q1sjr4 110 7 - - HYPH cord-307853-m1q1sjr4 110 8 CoV CoV NNP cord-307853-m1q1sjr4 110 9 S S NNP cord-307853-m1q1sjr4 110 10 , , , cord-307853-m1q1sjr4 110 11 which which WDT cord-307853-m1q1sjr4 110 12 is be VBZ cord-307853-m1q1sjr4 110 13 the the DT cord-307853-m1q1sjr4 110 14 lying lie VBG cord-307853-m1q1sjr4 110 15 state state NN cord-307853-m1q1sjr4 110 16 , , , cord-307853-m1q1sjr4 110 17 the the DT cord-307853-m1q1sjr4 110 18 RBD RBD NNP cord-307853-m1q1sjr4 110 19 is be VBZ cord-307853-m1q1sjr4 110 20 buried bury VBN cord-307853-m1q1sjr4 110 21 in in IN cord-307853-m1q1sjr4 110 22 the the DT cord-307853-m1q1sjr4 110 23 S S NNP cord-307853-m1q1sjr4 110 24 protein protein NN cord-307853-m1q1sjr4 110 25 trimer trimer NN cord-307853-m1q1sjr4 110 26 therefore therefore RB cord-307853-m1q1sjr4 110 27 interaction interaction NN cord-307853-m1q1sjr4 110 28 with with IN cord-307853-m1q1sjr4 110 29 ACE ace NN cord-307853-m1q1sjr4 110 30 receptor receptor NN cord-307853-m1q1sjr4 110 31 is be VBZ cord-307853-m1q1sjr4 110 32 hindered hinder VBN cord-307853-m1q1sjr4 110 33 . . . cord-307853-m1q1sjr4 111 1 In in IN cord-307853-m1q1sjr4 111 2 order order NN cord-307853-m1q1sjr4 111 3 to to TO cord-307853-m1q1sjr4 111 4 bind bind VB cord-307853-m1q1sjr4 111 5 with with IN cord-307853-m1q1sjr4 111 6 receptor receptor NN cord-307853-m1q1sjr4 111 7 , , , cord-307853-m1q1sjr4 111 8 S S NNP cord-307853-m1q1sjr4 111 9 protein protein NN cord-307853-m1q1sjr4 111 10 must must MD cord-307853-m1q1sjr4 111 11 switch switch VB cord-307853-m1q1sjr4 111 12 to to IN cord-307853-m1q1sjr4 111 13 standing stand VBG cord-307853-m1q1sjr4 111 14 state state NN cord-307853-m1q1sjr4 111 15 where where WRB cord-307853-m1q1sjr4 111 16 RBD RBD NNP cord-307853-m1q1sjr4 111 17 of of IN cord-307853-m1q1sjr4 111 18 any any DT cord-307853-m1q1sjr4 111 19 one one CD cord-307853-m1q1sjr4 111 20 of of IN cord-307853-m1q1sjr4 111 21 the the DT cord-307853-m1q1sjr4 111 22 chains chain NNS cord-307853-m1q1sjr4 111 23 is be VBZ cord-307853-m1q1sjr4 111 24 exposed expose VBN cord-307853-m1q1sjr4 111 25 and and CC cord-307853-m1q1sjr4 111 26 binds bind VBZ cord-307853-m1q1sjr4 111 27 with with IN cord-307853-m1q1sjr4 111 28 receptor receptor NN cord-307853-m1q1sjr4 111 29 [ [ -LRB- cord-307853-m1q1sjr4 111 30 8 8 CD cord-307853-m1q1sjr4 111 31 ] ] -RRB- cord-307853-m1q1sjr4 112 1 ( ( -LRB- cord-307853-m1q1sjr4 112 2 Fig Fig NNP cord-307853-m1q1sjr4 112 3 . . . cord-307853-m1q1sjr4 112 4 8) 8) NNP cord-307853-m1q1sjr4 112 5 . . . cord-307853-m1q1sjr4 113 1 From from IN cord-307853-m1q1sjr4 113 2 the the DT cord-307853-m1q1sjr4 113 3 homogenous homogenous JJ cord-307853-m1q1sjr4 113 4 CCM CCM NNP cord-307853-m1q1sjr4 113 5 plot plot NN cord-307853-m1q1sjr4 113 6 of of IN cord-307853-m1q1sjr4 113 7 whole whole JJ cord-307853-m1q1sjr4 113 8 trimer trimer NN cord-307853-m1q1sjr4 113 9 ( ( -LRB- cord-307853-m1q1sjr4 113 10 Fig Fig NNP cord-307853-m1q1sjr4 113 11 . . NNP cord-307853-m1q1sjr4 113 12 2 2 CD cord-307853-m1q1sjr4 113 13 ) ) -RRB- cord-307853-m1q1sjr4 113 14 , , , cord-307853-m1q1sjr4 113 15 we -PRON- PRP cord-307853-m1q1sjr4 113 16 hypothesize hypothesize VBP cord-307853-m1q1sjr4 113 17 that that IN cord-307853-m1q1sjr4 113 18 the the DT cord-307853-m1q1sjr4 113 19 molecular molecular JJ cord-307853-m1q1sjr4 113 20 mechanism mechanism NN cord-307853-m1q1sjr4 113 21 of of IN cord-307853-m1q1sjr4 113 22 this this DT cord-307853-m1q1sjr4 113 23 conformational conformational JJ cord-307853-m1q1sjr4 113 24 switching switch VBG cord-307853-m1q1sjr4 113 25 at at IN cord-307853-m1q1sjr4 113 26 atomic atomic JJ cord-307853-m1q1sjr4 113 27 scale scale NN cord-307853-m1q1sjr4 113 28 may may MD cord-307853-m1q1sjr4 113 29 be be VB cord-307853-m1q1sjr4 113 30 similar similar JJ cord-307853-m1q1sjr4 113 31 in in IN cord-307853-m1q1sjr4 113 32 nature nature NN cord-307853-m1q1sjr4 113 33 in in IN cord-307853-m1q1sjr4 113 34 the the DT cord-307853-m1q1sjr4 113 35 three three CD cord-307853-m1q1sjr4 113 36 viruses virus NNS cord-307853-m1q1sjr4 113 37 but but CC cord-307853-m1q1sjr4 113 38 the the DT cord-307853-m1q1sjr4 113 39 variation variation NN cord-307853-m1q1sjr4 113 40 seen see VBN cord-307853-m1q1sjr4 113 41 in in IN cord-307853-m1q1sjr4 113 42 the the DT cord-307853-m1q1sjr4 113 43 CCM ccm NN cord-307853-m1q1sjr4 113 44 of of IN cord-307853-m1q1sjr4 113 45 RBM RBM NNP cord-307853-m1q1sjr4 113 46 and and CC cord-307853-m1q1sjr4 113 47 RBD RBD NNP cord-307853-m1q1sjr4 113 48 are be VBP cord-307853-m1q1sjr4 113 49 responsible responsible JJ cord-307853-m1q1sjr4 113 50 for for IN cord-307853-m1q1sjr4 113 51 the the DT cord-307853-m1q1sjr4 113 52 difference difference NN cord-307853-m1q1sjr4 113 53 in in IN cord-307853-m1q1sjr4 113 54 infectivity infectivity NN cord-307853-m1q1sjr4 113 55 . . . cord-307853-m1q1sjr4 114 1 It -PRON- PRP cord-307853-m1q1sjr4 114 2 can can MD cord-307853-m1q1sjr4 114 3 be be VB cord-307853-m1q1sjr4 114 4 said say VBN cord-307853-m1q1sjr4 114 5 from from IN cord-307853-m1q1sjr4 114 6 the the DT cord-307853-m1q1sjr4 114 7 CCM CCM NNP cord-307853-m1q1sjr4 114 8 that that WDT cord-307853-m1q1sjr4 114 9 RBD RBD NNP cord-307853-m1q1sjr4 114 10 of of IN cord-307853-m1q1sjr4 114 11 all all DT cord-307853-m1q1sjr4 114 12 three three CD cord-307853-m1q1sjr4 114 13 chains chain NNS cord-307853-m1q1sjr4 114 14 have have VBP cord-307853-m1q1sjr4 114 15 equal equal JJ cord-307853-m1q1sjr4 114 16 probability probability NN cord-307853-m1q1sjr4 114 17 to to TO cord-307853-m1q1sjr4 114 18 be be VB cord-307853-m1q1sjr4 114 19 switched switch VBN cord-307853-m1q1sjr4 114 20 into into IN cord-307853-m1q1sjr4 114 21 standing stand VBG cord-307853-m1q1sjr4 114 22 state state NN cord-307853-m1q1sjr4 114 23 . . . cord-307853-m1q1sjr4 115 1 From from IN cord-307853-m1q1sjr4 115 2 the the DT cord-307853-m1q1sjr4 115 3 first first JJ cord-307853-m1q1sjr4 115 4 four four CD cord-307853-m1q1sjr4 115 5 low low JJ cord-307853-m1q1sjr4 115 6 frequency frequency NN cord-307853-m1q1sjr4 115 7 non non JJ cord-307853-m1q1sjr4 115 8 - - JJ cord-307853-m1q1sjr4 115 9 zero zero JJ cord-307853-m1q1sjr4 115 10 modes mode NNS cord-307853-m1q1sjr4 115 11 ( ( -LRB- cord-307853-m1q1sjr4 115 12 λ λ NNP cord-307853-m1q1sjr4 115 13 7 7 CD cord-307853-m1q1sjr4 115 14 , , , cord-307853-m1q1sjr4 115 15 λ λ NNP cord-307853-m1q1sjr4 115 16 8 8 CD cord-307853-m1q1sjr4 115 17 , , , cord-307853-m1q1sjr4 115 18 λ λ NNP cord-307853-m1q1sjr4 115 19 9 9 CD cord-307853-m1q1sjr4 115 20 , , , cord-307853-m1q1sjr4 115 21 λ λ NNP cord-307853-m1q1sjr4 115 22 10 10 CD cord-307853-m1q1sjr4 115 23 ) ) -RRB- cord-307853-m1q1sjr4 115 24 localized localize VBN cord-307853-m1q1sjr4 115 25 variation variation NN cord-307853-m1q1sjr4 115 26 in in IN cord-307853-m1q1sjr4 115 27 the the DT cord-307853-m1q1sjr4 115 28 direction direction NN cord-307853-m1q1sjr4 115 29 of of IN cord-307853-m1q1sjr4 115 30 C C NNP cord-307853-m1q1sjr4 115 31 α α NN cord-307853-m1q1sjr4 115 32 atom atom NN cord-307853-m1q1sjr4 115 33 motion motion NN cord-307853-m1q1sjr4 115 34 in in IN cord-307853-m1q1sjr4 115 35 the the DT cord-307853-m1q1sjr4 115 36 models model NNS cord-307853-m1q1sjr4 115 37 are be VBP cord-307853-m1q1sjr4 115 38 worth worth JJ cord-307853-m1q1sjr4 115 39 noticeable noticeable JJ cord-307853-m1q1sjr4 116 1 ( ( -LRB- cord-307853-m1q1sjr4 116 2 Fig Fig NNP cord-307853-m1q1sjr4 116 3 . . NNP cord-307853-m1q1sjr4 116 4 5 5 CD cord-307853-m1q1sjr4 116 5 ) ) -RRB- cord-307853-m1q1sjr4 116 6 . . . cord-307853-m1q1sjr4 117 1 We -PRON- PRP cord-307853-m1q1sjr4 117 2 have have VBP cord-307853-m1q1sjr4 117 3 also also RB cord-307853-m1q1sjr4 117 4 described describe VBN cord-307853-m1q1sjr4 117 5 the the DT cord-307853-m1q1sjr4 117 6 motions motion NNS cord-307853-m1q1sjr4 117 7 of of IN cord-307853-m1q1sjr4 117 8 the the DT cord-307853-m1q1sjr4 117 9 C c NN cord-307853-m1q1sjr4 117 10 α α NN cord-307853-m1q1sjr4 117 11 respect respect NN cord-307853-m1q1sjr4 117 12 to to IN cord-307853-m1q1sjr4 117 13 the the DT cord-307853-m1q1sjr4 117 14 symmetry symmetry NN cord-307853-m1q1sjr4 117 15 axis axis NN cord-307853-m1q1sjr4 117 16 of of IN cord-307853-m1q1sjr4 117 17 the the DT cord-307853-m1q1sjr4 117 18 trimer trimer NN cord-307853-m1q1sjr4 117 19 ( ( -LRB- cord-307853-m1q1sjr4 117 20 supplementary supplementary JJ cord-307853-m1q1sjr4 117 21 receptor receptor NN cord-307853-m1q1sjr4 117 22 . . . cord-307853-m1q1sjr4 118 1 This this DT cord-307853-m1q1sjr4 118 2 leads lead VBZ cord-307853-m1q1sjr4 118 3 to to IN cord-307853-m1q1sjr4 118 4 more more RBR cord-307853-m1q1sjr4 118 5 tight tight JJ cord-307853-m1q1sjr4 118 6 binding binding NN cord-307853-m1q1sjr4 118 7 of of IN cord-307853-m1q1sjr4 118 8 SARS SARS NNP cord-307853-m1q1sjr4 118 9 - - HYPH cord-307853-m1q1sjr4 118 10 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 118 11 S S NNP cord-307853-m1q1sjr4 118 12 protein protein NN cord-307853-m1q1sjr4 118 13 RBD RBD NNP cord-307853-m1q1sjr4 118 14 to to IN cord-307853-m1q1sjr4 118 15 the the DT cord-307853-m1q1sjr4 118 16 receptor receptor NN cord-307853-m1q1sjr4 118 17 than than IN cord-307853-m1q1sjr4 118 18 SARS SARS NNP cord-307853-m1q1sjr4 118 19 - - HYPH cord-307853-m1q1sjr4 118 20 CoV CoV NNP cord-307853-m1q1sjr4 118 21 and and CC cord-307853-m1q1sjr4 118 22 it -PRON- PRP cord-307853-m1q1sjr4 118 23 explains explain VBZ cord-307853-m1q1sjr4 118 24 partially partially RB cord-307853-m1q1sjr4 118 25 , , , cord-307853-m1q1sjr4 118 26 why why WRB cord-307853-m1q1sjr4 118 27 SARS SARS NNP cord-307853-m1q1sjr4 118 28 - - HYPH cord-307853-m1q1sjr4 118 29 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 118 30 is be VBZ cord-307853-m1q1sjr4 118 31 10 10 CD cord-307853-m1q1sjr4 118 32 to to TO cord-307853-m1q1sjr4 118 33 15 15 CD cord-307853-m1q1sjr4 118 34 times time NNS cord-307853-m1q1sjr4 118 35 more more RBR cord-307853-m1q1sjr4 118 36 infective infective JJ cord-307853-m1q1sjr4 118 37 than than IN cord-307853-m1q1sjr4 118 38 SARS SARS NNP cord-307853-m1q1sjr4 118 39 - - HYPH cord-307853-m1q1sjr4 118 40 CoV CoV NNP cord-307853-m1q1sjr4 118 41 [ [ -LRB- cord-307853-m1q1sjr4 118 42 31 31 CD cord-307853-m1q1sjr4 118 43 ] ] -RRB- cord-307853-m1q1sjr4 118 44 . . . cord-307853-m1q1sjr4 119 1 Cryo cryo NN cord-307853-m1q1sjr4 119 2 - - HYPH cord-307853-m1q1sjr4 119 3 EM EM NNP cord-307853-m1q1sjr4 119 4 studies study NNS cord-307853-m1q1sjr4 119 5 have have VBP cord-307853-m1q1sjr4 119 6 shown show VBN cord-307853-m1q1sjr4 119 7 that that IN cord-307853-m1q1sjr4 119 8 , , , cord-307853-m1q1sjr4 119 9 in in IN cord-307853-m1q1sjr4 119 10 SARS SARS NNP cord-307853-m1q1sjr4 119 11 - - HYPH cord-307853-m1q1sjr4 119 12 CoV CoV NNP cord-307853-m1q1sjr4 119 13 spike spike NN cord-307853-m1q1sjr4 119 14 , , , cord-307853-m1q1sjr4 119 15 the the DT cord-307853-m1q1sjr4 119 16 RBD RBD NNP cord-307853-m1q1sjr4 119 17 is be VBZ cord-307853-m1q1sjr4 119 18 mostly mostly RB cord-307853-m1q1sjr4 119 19 in in IN cord-307853-m1q1sjr4 119 20 the the DT cord-307853-m1q1sjr4 119 21 standing stand VBG cord-307853-m1q1sjr4 119 22 state state NN cord-307853-m1q1sjr4 119 23 [ [ -LRB- cord-307853-m1q1sjr4 119 24 8 8 CD cord-307853-m1q1sjr4 119 25 , , , cord-307853-m1q1sjr4 119 26 11 11 CD cord-307853-m1q1sjr4 119 27 ] ] -RRB- cord-307853-m1q1sjr4 119 28 however however RB cord-307853-m1q1sjr4 119 29 , , , cord-307853-m1q1sjr4 119 30 in in IN cord-307853-m1q1sjr4 119 31 SARS SARS NNP cord-307853-m1q1sjr4 119 32 - - HYPH cord-307853-m1q1sjr4 119 33 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 119 34 spike spike NN cord-307853-m1q1sjr4 119 35 , , , cord-307853-m1q1sjr4 119 36 the the DT cord-307853-m1q1sjr4 119 37 RBD RBD NNP cord-307853-m1q1sjr4 119 38 is be VBZ cord-307853-m1q1sjr4 119 39 mostly mostly RB cord-307853-m1q1sjr4 119 40 in in IN cord-307853-m1q1sjr4 119 41 the the DT cord-307853-m1q1sjr4 119 42 lying lie VBG cord-307853-m1q1sjr4 119 43 state state NN cord-307853-m1q1sjr4 119 44 _SP cord-307853-m1q1sjr4 120 1 The the DT cord-307853-m1q1sjr4 120 2 present present JJ cord-307853-m1q1sjr4 120 3 comprehensive comprehensive JJ cord-307853-m1q1sjr4 120 4 study study NN cord-307853-m1q1sjr4 120 5 demonstrated demonstrate VBD cord-307853-m1q1sjr4 120 6 the the DT cord-307853-m1q1sjr4 120 7 intrinsic intrinsic JJ cord-307853-m1q1sjr4 120 8 dynamics dynamic NNS cord-307853-m1q1sjr4 120 9 of of IN cord-307853-m1q1sjr4 120 10 the the DT cord-307853-m1q1sjr4 120 11 S S NNP cord-307853-m1q1sjr4 120 12 proteins protein NNS cord-307853-m1q1sjr4 120 13 from from IN cord-307853-m1q1sjr4 120 14 SARS SARS NNP cord-307853-m1q1sjr4 120 15 - - HYPH cord-307853-m1q1sjr4 120 16 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 120 17 , , , cord-307853-m1q1sjr4 120 18 SARS SARS NNP cord-307853-m1q1sjr4 120 19 - - HYPH cord-307853-m1q1sjr4 120 20 CoV CoV NNP cord-307853-m1q1sjr4 120 21 and and CC cord-307853-m1q1sjr4 120 22 MERS MERS NNP cord-307853-m1q1sjr4 120 23 - - HYPH cord-307853-m1q1sjr4 120 24 CoV CoV NNP cord-307853-m1q1sjr4 120 25 and and CC cord-307853-m1q1sjr4 120 26 their -PRON- PRP$ cord-307853-m1q1sjr4 120 27 inter inter JJ cord-307853-m1q1sjr4 120 28 - - JJ cord-307853-m1q1sjr4 120 29 relationship relationship NN cord-307853-m1q1sjr4 120 30 through through IN cord-307853-m1q1sjr4 120 31 normal normal JJ cord-307853-m1q1sjr4 120 32 mode mode NN cord-307853-m1q1sjr4 120 33 analysis analysis NN cord-307853-m1q1sjr4 120 34 using use VBG cord-307853-m1q1sjr4 120 35 ANM ANM NNP cord-307853-m1q1sjr4 120 36 . . . cord-307853-m1q1sjr4 121 1 High high JJ cord-307853-m1q1sjr4 121 2 fluctuation fluctuation NN cord-307853-m1q1sjr4 121 3 of of IN cord-307853-m1q1sjr4 121 4 the the DT cord-307853-m1q1sjr4 121 5 RBM RBM NNP cord-307853-m1q1sjr4 121 6 of of IN cord-307853-m1q1sjr4 121 7 SARS SARS NNP cord-307853-m1q1sjr4 121 8 - - HYPH cord-307853-m1q1sjr4 121 9 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 121 10 spike spike NN cord-307853-m1q1sjr4 121 11 indicates indicate VBZ cord-307853-m1q1sjr4 121 12 its -PRON- PRP$ cord-307853-m1q1sjr4 121 13 propensity propensity NN cord-307853-m1q1sjr4 121 14 to to TO cord-307853-m1q1sjr4 121 15 bind bind VB cord-307853-m1q1sjr4 121 16 with with IN cord-307853-m1q1sjr4 121 17 ACE2 ACE2 NNP cord-307853-m1q1sjr4 121 18 even even RB cord-307853-m1q1sjr4 121 19 in in IN cord-307853-m1q1sjr4 121 20 the the DT cord-307853-m1q1sjr4 121 21 lying lie VBG cord-307853-m1q1sjr4 121 22 state state NN cord-307853-m1q1sjr4 121 23 inferring infer VBG cord-307853-m1q1sjr4 121 24 its -PRON- PRP$ cord-307853-m1q1sjr4 121 25 higher high JJR cord-307853-m1q1sjr4 121 26 infectivity infectivity NN cord-307853-m1q1sjr4 121 27 than than IN cord-307853-m1q1sjr4 121 28 SARS SARS NNP cord-307853-m1q1sjr4 121 29 - - HYPH cord-307853-m1q1sjr4 121 30 CoV CoV NNP cord-307853-m1q1sjr4 121 31 and and CC cord-307853-m1q1sjr4 121 32 MERS- MERS- NNP cord-307853-m1q1sjr4 122 1 CoV. CoV. NNP cord-307853-m1q1sjr4 123 1 The the DT cord-307853-m1q1sjr4 123 2 distant distant JJ cord-307853-m1q1sjr4 123 3 relationship relationship NN cord-307853-m1q1sjr4 123 4 of of IN cord-307853-m1q1sjr4 123 5 MERS MERS NNP cord-307853-m1q1sjr4 123 6 - - HYPH cord-307853-m1q1sjr4 123 7 CoV CoV NNP cord-307853-m1q1sjr4 123 8 with with IN cord-307853-m1q1sjr4 123 9 the the DT cord-307853-m1q1sjr4 123 10 SARS SARS NNP cord-307853-m1q1sjr4 123 11 - - HYPH cord-307853-m1q1sjr4 123 12 CoV CoV NNP cord-307853-m1q1sjr4 123 13 and and CC cord-307853-m1q1sjr4 123 14 SARS SARS NNP cord-307853-m1q1sjr4 123 15 - - HYPH cord-307853-m1q1sjr4 123 16 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 123 17 in in IN cord-307853-m1q1sjr4 123 18 phylogenetic phylogenetic JJ cord-307853-m1q1sjr4 123 19 tree tree NN cord-307853-m1q1sjr4 123 20 at at IN cord-307853-m1q1sjr4 123 21 sequence sequence NN cord-307853-m1q1sjr4 123 22 level level NN cord-307853-m1q1sjr4 123 23 resembles resemble VBZ cord-307853-m1q1sjr4 123 24 that that IN cord-307853-m1q1sjr4 123 25 at at IN cord-307853-m1q1sjr4 123 26 the the DT cord-307853-m1q1sjr4 123 27 dynamics dynamic NNS cord-307853-m1q1sjr4 123 28 level level NN cord-307853-m1q1sjr4 123 29 due due IN cord-307853-m1q1sjr4 123 30 to to IN cord-307853-m1q1sjr4 123 31 its -PRON- PRP$ cord-307853-m1q1sjr4 123 32 unique unique JJ cord-307853-m1q1sjr4 123 33 dynamical dynamical JJ cord-307853-m1q1sjr4 123 34 motion motion NN cord-307853-m1q1sjr4 123 35 . . . cord-307853-m1q1sjr4 124 1 Sites site NNS cord-307853-m1q1sjr4 124 2 of of IN cord-307853-m1q1sjr4 124 3 very very RB cord-307853-m1q1sjr4 124 4 low low JJ cord-307853-m1q1sjr4 124 5 atomic atomic JJ cord-307853-m1q1sjr4 124 6 fluctuation fluctuation NN cord-307853-m1q1sjr4 124 7 at at IN cord-307853-m1q1sjr4 124 8 the the DT cord-307853-m1q1sjr4 124 9 S1 S1 NNP cord-307853-m1q1sjr4 124 10 site site NN cord-307853-m1q1sjr4 124 11 which which WDT cord-307853-m1q1sjr4 124 12 harbours harbour VBZ cord-307853-m1q1sjr4 124 13 the the DT cord-307853-m1q1sjr4 124 14 RBD RBD NNP cord-307853-m1q1sjr4 124 15 could could MD cord-307853-m1q1sjr4 124 16 serve serve VB cord-307853-m1q1sjr4 124 17 as as IN cord-307853-m1q1sjr4 124 18 the the DT cord-307853-m1q1sjr4 124 19 potential potential JJ cord-307853-m1q1sjr4 124 20 drug drug NN cord-307853-m1q1sjr4 124 21 binding binding NN cord-307853-m1q1sjr4 124 22 site site NN cord-307853-m1q1sjr4 124 23 . . . cord-307853-m1q1sjr4 125 1 Our -PRON- PRP$ cord-307853-m1q1sjr4 125 2 study study NN cord-307853-m1q1sjr4 125 3 could could MD cord-307853-m1q1sjr4 125 4 serve serve VB cord-307853-m1q1sjr4 125 5 as as IN cord-307853-m1q1sjr4 125 6 the the DT cord-307853-m1q1sjr4 125 7 basis basis NN cord-307853-m1q1sjr4 125 8 for for IN cord-307853-m1q1sjr4 125 9 J J NNP cord-307853-m1q1sjr4 125 10 o o NNP cord-307853-m1q1sjr4 125 11 u u NN cord-307853-m1q1sjr4 125 12 r r NN cord-307853-m1q1sjr4 125 13 n n NN cord-307853-m1q1sjr4 125 14 a a DT cord-307853-m1q1sjr4 125 15 l l NN cord-307853-m1q1sjr4 125 16 P p NN cord-307853-m1q1sjr4 125 17 r r NN cord-307853-m1q1sjr4 125 18 e e NN cord-307853-m1q1sjr4 125 19 -p -p NN cord-307853-m1q1sjr4 126 1 r r NN cord-307853-m1q1sjr4 126 2 o o NN cord-307853-m1q1sjr4 126 3 o o NN cord-307853-m1q1sjr4 126 4 f f NN cord-307853-m1q1sjr4 126 5 designing design VBG cord-307853-m1q1sjr4 126 6 common common JJ cord-307853-m1q1sjr4 126 7 potential potential JJ cord-307853-m1q1sjr4 126 8 drugs drug NNS cord-307853-m1q1sjr4 126 9 against against IN cord-307853-m1q1sjr4 126 10 the the DT cord-307853-m1q1sjr4 126 11 spike spike NN cord-307853-m1q1sjr4 126 12 of of IN cord-307853-m1q1sjr4 126 13 the the DT cord-307853-m1q1sjr4 126 14 three three CD cord-307853-m1q1sjr4 126 15 mentioned mention VBN cord-307853-m1q1sjr4 126 16 viruses virus NNS cord-307853-m1q1sjr4 126 17 which which WDT cord-307853-m1q1sjr4 126 18 may may MD cord-307853-m1q1sjr4 126 19 inhibit inhibit VB cord-307853-m1q1sjr4 126 20 the the DT cord-307853-m1q1sjr4 126 21 conformational conformational JJ cord-307853-m1q1sjr4 126 22 changes change NNS cord-307853-m1q1sjr4 126 23 from from IN cord-307853-m1q1sjr4 126 24 lying lie VBG cord-307853-m1q1sjr4 126 25 to to IN cord-307853-m1q1sjr4 126 26 standing stand VBG cord-307853-m1q1sjr4 126 27 state state NN cord-307853-m1q1sjr4 126 28 . . . cord-307853-m1q1sjr4 127 1 COVID-19 covid-19 JJ cord-307853-m1q1sjr4 127 2 infection infection NN cord-307853-m1q1sjr4 127 3 : : : cord-307853-m1q1sjr4 127 4 Origin origin NN cord-307853-m1q1sjr4 127 5 , , , cord-307853-m1q1sjr4 127 6 transmission transmission NN cord-307853-m1q1sjr4 127 7 , , , cord-307853-m1q1sjr4 127 8 and and CC cord-307853-m1q1sjr4 127 9 characteristics characteristic NNS cord-307853-m1q1sjr4 127 10 of of IN cord-307853-m1q1sjr4 127 11 human human JJ cord-307853-m1q1sjr4 127 12 coronaviruses coronaviruse NNS cord-307853-m1q1sjr4 127 13 Jumping jump VBG cord-307853-m1q1sjr4 127 14 species specie NNS cord-307853-m1q1sjr4 127 15 - - : cord-307853-m1q1sjr4 127 16 a a DT cord-307853-m1q1sjr4 127 17 mechanism mechanism NN cord-307853-m1q1sjr4 127 18 for for IN cord-307853-m1q1sjr4 127 19 coronavirus coronavirus NN cord-307853-m1q1sjr4 127 20 persistence persistence NN cord-307853-m1q1sjr4 127 21 and and CC cord-307853-m1q1sjr4 127 22 survival survival NN cord-307853-m1q1sjr4 127 23 WHO who WP cord-307853-m1q1sjr4 127 24 | | NNP cord-307853-m1q1sjr4 127 25 Summary Summary NNP cord-307853-m1q1sjr4 127 26 of of IN cord-307853-m1q1sjr4 127 27 probable probable JJ cord-307853-m1q1sjr4 127 28 SARS SARS NNP cord-307853-m1q1sjr4 127 29 cases case NNS cord-307853-m1q1sjr4 127 30 with with IN cord-307853-m1q1sjr4 127 31 onset onset NN cord-307853-m1q1sjr4 127 32 of of IN cord-307853-m1q1sjr4 127 33 illness illness NN cord-307853-m1q1sjr4 127 34 from from IN cord-307853-m1q1sjr4 127 35 1 1 CD cord-307853-m1q1sjr4 127 36 Middle Middle NNP cord-307853-m1q1sjr4 127 37 East East NNP cord-307853-m1q1sjr4 127 38 respiratory respiratory JJ cord-307853-m1q1sjr4 127 39 syndrome syndrome NN cord-307853-m1q1sjr4 127 40 coronavirus coronavirus NN cord-307853-m1q1sjr4 127 41 ( ( -LRB- cord-307853-m1q1sjr4 127 42 MERS MERS NNP cord-307853-m1q1sjr4 127 43 - - HYPH cord-307853-m1q1sjr4 127 44 CoV CoV NNP cord-307853-m1q1sjr4 127 45 ) ) -RRB- cord-307853-m1q1sjr4 128 1 Immunogenicity immunogenicity NN cord-307853-m1q1sjr4 128 2 of of IN cord-307853-m1q1sjr4 128 3 a a DT cord-307853-m1q1sjr4 128 4 DNA dna NN cord-307853-m1q1sjr4 128 5 vaccine vaccine NN cord-307853-m1q1sjr4 128 6 candidate candidate NN cord-307853-m1q1sjr4 128 7 for for IN cord-307853-m1q1sjr4 128 8 COVID-19 COVID-19 NNP cord-307853-m1q1sjr4 128 9 Structural structural JJ cord-307853-m1q1sjr4 128 10 insights insight NNS cord-307853-m1q1sjr4 128 11 into into IN cord-307853-m1q1sjr4 128 12 coronavirus coronavirus NN cord-307853-m1q1sjr4 128 13 entry entry NN cord-307853-m1q1sjr4 128 14 Pre pre JJ cord-307853-m1q1sjr4 128 15 - - JJ cord-307853-m1q1sjr4 128 16 fusion fusion JJ cord-307853-m1q1sjr4 128 17 structure structure NN cord-307853-m1q1sjr4 128 18 of of IN cord-307853-m1q1sjr4 128 19 a a DT cord-307853-m1q1sjr4 128 20 human human JJ cord-307853-m1q1sjr4 128 21 coronavirus coronavirus NN cord-307853-m1q1sjr4 128 22 spike spike NN cord-307853-m1q1sjr4 128 23 protein protein NN cord-307853-m1q1sjr4 128 24 Cryo cryo NN cord-307853-m1q1sjr4 128 25 - - HYPH cord-307853-m1q1sjr4 128 26 electron electron NN cord-307853-m1q1sjr4 128 27 microscopy microscopy NN cord-307853-m1q1sjr4 128 28 structures structure NNS cord-307853-m1q1sjr4 128 29 of of IN cord-307853-m1q1sjr4 128 30 the the DT cord-307853-m1q1sjr4 128 31 SARS SARS NNP cord-307853-m1q1sjr4 128 32 - - HYPH cord-307853-m1q1sjr4 128 33 CoV CoV NNP cord-307853-m1q1sjr4 128 34 spike spike NN cord-307853-m1q1sjr4 128 35 glycoprotein glycoprotein NN cord-307853-m1q1sjr4 128 36 reveal reveal VBP cord-307853-m1q1sjr4 128 37 a a DT cord-307853-m1q1sjr4 128 38 prerequisite prerequisite JJ cord-307853-m1q1sjr4 128 39 conformational conformational JJ cord-307853-m1q1sjr4 128 40 state state NN cord-307853-m1q1sjr4 128 41 for for IN cord-307853-m1q1sjr4 128 42 receptor receptor NN cord-307853-m1q1sjr4 128 43 binding bind VBG cord-307853-m1q1sjr4 128 44 Isolation isolation NN cord-307853-m1q1sjr4 128 45 and and CC cord-307853-m1q1sjr4 128 46 characterization characterization NN cord-307853-m1q1sjr4 128 47 of of IN cord-307853-m1q1sjr4 128 48 a a DT cord-307853-m1q1sjr4 128 49 bat bat NN cord-307853-m1q1sjr4 128 50 SARS SARS NNP cord-307853-m1q1sjr4 128 51 - - HYPH cord-307853-m1q1sjr4 128 52 like like JJ cord-307853-m1q1sjr4 128 53 coronavirus coronavirus NN cord-307853-m1q1sjr4 128 54 that that WDT cord-307853-m1q1sjr4 128 55 uses use VBZ cord-307853-m1q1sjr4 128 56 the the DT cord-307853-m1q1sjr4 128 57 ACE2 ACE2 NNP cord-307853-m1q1sjr4 128 58 receptor receptor NN cord-307853-m1q1sjr4 128 59 Stabilized stabilize VBD cord-307853-m1q1sjr4 128 60 coronavirus coronavirus NN cord-307853-m1q1sjr4 128 61 spikes spike NNS cord-307853-m1q1sjr4 128 62 are be VBP cord-307853-m1q1sjr4 128 63 resistant resistant JJ cord-307853-m1q1sjr4 128 64 to to TO cord-307853-m1q1sjr4 128 65 conformational conformational JJ cord-307853-m1q1sjr4 128 66 changes change NNS cord-307853-m1q1sjr4 128 67 induced induce VBN cord-307853-m1q1sjr4 128 68 by by IN cord-307853-m1q1sjr4 128 69 receptor receptor NN cord-307853-m1q1sjr4 128 70 recognition recognition NN cord-307853-m1q1sjr4 128 71 or or CC cord-307853-m1q1sjr4 128 72 proteolysis proteolysis NN cord-307853-m1q1sjr4 128 73 Cryo Cryo NNP cord-307853-m1q1sjr4 128 74 - - HYPH cord-307853-m1q1sjr4 128 75 EM EM NNP cord-307853-m1q1sjr4 128 76 structures structure NNS cord-307853-m1q1sjr4 128 77 of of IN cord-307853-m1q1sjr4 128 78 MERS MERS NNP cord-307853-m1q1sjr4 128 79 - - HYPH cord-307853-m1q1sjr4 128 80 CoV CoV NNP cord-307853-m1q1sjr4 128 81 and and CC cord-307853-m1q1sjr4 128 82 SARS SARS NNP cord-307853-m1q1sjr4 128 83 - - HYPH cord-307853-m1q1sjr4 128 84 CoV CoV NNP cord-307853-m1q1sjr4 128 85 spike spike NN cord-307853-m1q1sjr4 128 86 glycoproteins glycoprotein NNS cord-307853-m1q1sjr4 128 87 reveal reveal VBP cord-307853-m1q1sjr4 128 88 the the DT cord-307853-m1q1sjr4 128 89 dynamic dynamic JJ cord-307853-m1q1sjr4 128 90 receptor receptor NN cord-307853-m1q1sjr4 128 91 binding bind VBG cord-307853-m1q1sjr4 128 92 domains domain NNS cord-307853-m1q1sjr4 128 93 Analysis Analysis NNP cord-307853-m1q1sjr4 128 94 of of IN cord-307853-m1q1sjr4 128 95 domain domain NN cord-307853-m1q1sjr4 128 96 motions motion NNS cord-307853-m1q1sjr4 128 97 in in IN cord-307853-m1q1sjr4 128 98 large large JJ cord-307853-m1q1sjr4 128 99 proteins protein NNS cord-307853-m1q1sjr4 128 100 Analysis Analysis NNP cord-307853-m1q1sjr4 128 101 of of IN cord-307853-m1q1sjr4 128 102 domain domain NN cord-307853-m1q1sjr4 128 103 motions motion NNS cord-307853-m1q1sjr4 128 104 by by IN cord-307853-m1q1sjr4 128 105 approximate approximate JJ cord-307853-m1q1sjr4 128 106 normal normal JJ cord-307853-m1q1sjr4 128 107 mode mode NN cord-307853-m1q1sjr4 128 108 calculations calculation NNS cord-307853-m1q1sjr4 128 109 Global Global NNP cord-307853-m1q1sjr4 128 110 Dynamics Dynamics NNPS cord-307853-m1q1sjr4 128 111 of of IN cord-307853-m1q1sjr4 128 112 Proteins protein NNS cord-307853-m1q1sjr4 128 113 : : : cord-307853-m1q1sjr4 129 1 Bridging bridge VBG cord-307853-m1q1sjr4 129 2 Between between IN cord-307853-m1q1sjr4 129 3 Structure Structure NNP cord-307853-m1q1sjr4 129 4 and and CC cord-307853-m1q1sjr4 129 5 Function Function NNP cord-307853-m1q1sjr4 129 6 Probing probe VBG cord-307853-m1q1sjr4 129 7 the the DT cord-307853-m1q1sjr4 129 8 global global JJ cord-307853-m1q1sjr4 129 9 and and CC cord-307853-m1q1sjr4 129 10 local local JJ cord-307853-m1q1sjr4 129 11 dynamics dynamic NNS cord-307853-m1q1sjr4 129 12 of of IN cord-307853-m1q1sjr4 129 13 aminoacyl aminoacyl NNP cord-307853-m1q1sjr4 129 14 - - HYPH cord-307853-m1q1sjr4 129 15 tRNA trna NN cord-307853-m1q1sjr4 129 16 synthetases synthetase NNS cord-307853-m1q1sjr4 129 17 using use VBG cord-307853-m1q1sjr4 129 18 all all DT cord-307853-m1q1sjr4 129 19 - - HYPH cord-307853-m1q1sjr4 129 20 atom atom NN cord-307853-m1q1sjr4 129 21 and and CC cord-307853-m1q1sjr4 129 22 coarse coarse RB cord-307853-m1q1sjr4 129 23 - - HYPH cord-307853-m1q1sjr4 129 24 grained grained JJ cord-307853-m1q1sjr4 129 25 simulations simulation NNS cord-307853-m1q1sjr4 129 26 Insights Insights NNPS cord-307853-m1q1sjr4 129 27 into into IN cord-307853-m1q1sjr4 129 28 Equilibrium Equilibrium NNP cord-307853-m1q1sjr4 129 29 Dynamics Dynamics NNPS cord-307853-m1q1sjr4 129 30 of of IN cord-307853-m1q1sjr4 129 31 Proteins protein NNS cord-307853-m1q1sjr4 129 32 from from IN cord-307853-m1q1sjr4 129 33 Comparison Comparison NNP cord-307853-m1q1sjr4 129 34 of of IN cord-307853-m1q1sjr4 129 35 NMR NMR NNP cord-307853-m1q1sjr4 129 36 and and CC cord-307853-m1q1sjr4 129 37 X X NNP cord-307853-m1q1sjr4 129 38 - - NNP cord-307853-m1q1sjr4 129 39 Ray Ray NNP cord-307853-m1q1sjr4 129 40 Data Data NNP cord-307853-m1q1sjr4 129 41 with with IN cord-307853-m1q1sjr4 129 42 Computational Computational NNP cord-307853-m1q1sjr4 129 43 Predictions Predictions NNPS cord-307853-m1q1sjr4 129 44 Coarse coarse RB cord-307853-m1q1sjr4 129 45 - - HYPH cord-307853-m1q1sjr4 129 46 grained grained JJ cord-307853-m1q1sjr4 129 47 normal normal JJ cord-307853-m1q1sjr4 129 48 mode mode NN cord-307853-m1q1sjr4 129 49 analysis analysis NN cord-307853-m1q1sjr4 129 50 in in IN cord-307853-m1q1sjr4 129 51 structural structural JJ cord-307853-m1q1sjr4 129 52 biology biology NN cord-307853-m1q1sjr4 129 53 Normal Normal NNP cord-307853-m1q1sjr4 129 54 Mode Mode NNP cord-307853-m1q1sjr4 129 55 Analysis Analysis NNP cord-307853-m1q1sjr4 129 56 : : : cord-307853-m1q1sjr4 129 57 Theory Theory NNP cord-307853-m1q1sjr4 129 58 and and CC cord-307853-m1q1sjr4 129 59 Applications Applications NNPS cord-307853-m1q1sjr4 129 60 to to IN cord-307853-m1q1sjr4 129 61 Biological Biological NNP cord-307853-m1q1sjr4 129 62 and and CC cord-307853-m1q1sjr4 129 63 Chemic Chemic NNP cord-307853-m1q1sjr4 129 64 Anisotropic Anisotropic NNP cord-307853-m1q1sjr4 129 65 network network NN cord-307853-m1q1sjr4 129 66 model model NN cord-307853-m1q1sjr4 129 67 : : : cord-307853-m1q1sjr4 129 68 systematic systematic JJ cord-307853-m1q1sjr4 129 69 evaluation evaluation NN cord-307853-m1q1sjr4 129 70 and and CC cord-307853-m1q1sjr4 129 71 a a DT cord-307853-m1q1sjr4 129 72 new new JJ cord-307853-m1q1sjr4 129 73 web web NN cord-307853-m1q1sjr4 129 74 interface interface NN cord-307853-m1q1sjr4 129 75 Normal normal JJ cord-307853-m1q1sjr4 129 76 mode mode NN cord-307853-m1q1sjr4 129 77 analysis analysis NN cord-307853-m1q1sjr4 129 78 of of IN cord-307853-m1q1sjr4 129 79 biomolecular biomolecular JJ cord-307853-m1q1sjr4 129 80 structures structure NNS cord-307853-m1q1sjr4 129 81 : : : cord-307853-m1q1sjr4 129 82 Functional functional JJ cord-307853-m1q1sjr4 129 83 mechanisms mechanism NNS cord-307853-m1q1sjr4 129 84 of of IN cord-307853-m1q1sjr4 129 85 membrane membrane NN cord-307853-m1q1sjr4 129 86 proteins protein NNS cord-307853-m1q1sjr4 130 1 Protein Protein NNP cord-307853-m1q1sjr4 130 2 Data Data NNP cord-307853-m1q1sjr4 130 3 Bank Bank NNP cord-307853-m1q1sjr4 130 4 | | NNP cord-307853-m1q1sjr4 131 1 Nucleic Nucleic NNP cord-307853-m1q1sjr4 131 2 Acids Acids NNPS cord-307853-m1q1sjr4 131 3 Research Research NNP cord-307853-m1q1sjr4 131 4 | | NNP cord-307853-m1q1sjr4 131 5 Oxford Oxford NNP cord-307853-m1q1sjr4 131 6 Academic Academic NNP cord-307853-m1q1sjr4 131 7 Structures Structures NNPS cord-307853-m1q1sjr4 131 8 of of IN cord-307853-m1q1sjr4 131 9 MERS MERS NNP cord-307853-m1q1sjr4 131 10 - - HYPH cord-307853-m1q1sjr4 131 11 CoV cov NN cord-307853-m1q1sjr4 131 12 spike spike NN cord-307853-m1q1sjr4 131 13 glycoprotein glycoprotein NN cord-307853-m1q1sjr4 131 14 in in IN cord-307853-m1q1sjr4 131 15 complex complex NN cord-307853-m1q1sjr4 131 16 with with IN cord-307853-m1q1sjr4 131 17 receptors receptor NNS cord-307853-m1q1sjr4 131 18 Structure Structure NNP cord-307853-m1q1sjr4 131 19 , , , cord-307853-m1q1sjr4 131 20 Function Function NNP cord-307853-m1q1sjr4 131 21 , , , cord-307853-m1q1sjr4 131 22 and and CC cord-307853-m1q1sjr4 131 23 Antigenicity Antigenicity NNP cord-307853-m1q1sjr4 131 24 of of IN cord-307853-m1q1sjr4 131 25 the the DT cord-307853-m1q1sjr4 131 26 SARS SARS NNP cord-307853-m1q1sjr4 131 27 - - HYPH cord-307853-m1q1sjr4 131 28 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 131 29 Spike Spike NNP cord-307853-m1q1sjr4 131 30 Glycoprotein Glycoprotein NNP cord-307853-m1q1sjr4 131 31 CHARMM CHARMM NNP cord-307853-m1q1sjr4 131 32 - - HYPH cord-307853-m1q1sjr4 131 33 GUI GUI NNP cord-307853-m1q1sjr4 131 34 : : : cord-307853-m1q1sjr4 132 1 A a DT cord-307853-m1q1sjr4 132 2 web web NN cord-307853-m1q1sjr4 132 3 - - HYPH cord-307853-m1q1sjr4 132 4 based base VBN cord-307853-m1q1sjr4 132 5 graphical graphical JJ cord-307853-m1q1sjr4 132 6 user user NN cord-307853-m1q1sjr4 132 7 interface interface NN cord-307853-m1q1sjr4 132 8 for for IN cord-307853-m1q1sjr4 132 9 CHARMM CHARMM NNP cord-307853-m1q1sjr4 132 10 Normal normal JJ cord-307853-m1q1sjr4 132 11 mode mode NN cord-307853-m1q1sjr4 132 12 analysis analysis NN cord-307853-m1q1sjr4 132 13 as as IN cord-307853-m1q1sjr4 132 14 a a DT cord-307853-m1q1sjr4 132 15 method method NN cord-307853-m1q1sjr4 132 16 to to TO cord-307853-m1q1sjr4 132 17 derive derive VB cord-307853-m1q1sjr4 132 18 protein protein NN cord-307853-m1q1sjr4 132 19 dynamics dynamic NNS cord-307853-m1q1sjr4 132 20 information information NN cord-307853-m1q1sjr4 132 21 from from IN cord-307853-m1q1sjr4 132 22 the the DT cord-307853-m1q1sjr4 132 23 Protein Protein NNP cord-307853-m1q1sjr4 132 24 Data Data NNP cord-307853-m1q1sjr4 132 25 Bank Bank NNP cord-307853-m1q1sjr4 132 26 Comparing compare VBG cord-307853-m1q1sjr4 132 27 the the DT cord-307853-m1q1sjr4 132 28 intrinsic intrinsic JJ cord-307853-m1q1sjr4 132 29 dynamics dynamic NNS cord-307853-m1q1sjr4 132 30 of of IN cord-307853-m1q1sjr4 132 31 multiple multiple JJ cord-307853-m1q1sjr4 132 32 protein protein NN cord-307853-m1q1sjr4 132 33 structures structure NNS cord-307853-m1q1sjr4 132 34 using use VBG cord-307853-m1q1sjr4 132 35 elastic elastic JJ cord-307853-m1q1sjr4 132 36 network network NN cord-307853-m1q1sjr4 132 37 models model NNS cord-307853-m1q1sjr4 132 38 Comparison comparison NN cord-307853-m1q1sjr4 132 39 of of IN cord-307853-m1q1sjr4 132 40 intrinsic intrinsic JJ cord-307853-m1q1sjr4 132 41 dynamics dynamic NNS cord-307853-m1q1sjr4 132 42 of of IN cord-307853-m1q1sjr4 132 43 cytochrome cytochrome NN cord-307853-m1q1sjr4 132 44 p450 p450 NN cord-307853-m1q1sjr4 132 45 proteins protein NNS cord-307853-m1q1sjr4 132 46 using use VBG cord-307853-m1q1sjr4 132 47 normal normal JJ cord-307853-m1q1sjr4 132 48 mode mode NN cord-307853-m1q1sjr4 132 49 analysis analysis NN cord-307853-m1q1sjr4 132 50 On on IN cord-307853-m1q1sjr4 132 51 the the DT cord-307853-m1q1sjr4 132 52 convergence convergence NN cord-307853-m1q1sjr4 132 53 of of IN cord-307853-m1q1sjr4 132 54 the the DT cord-307853-m1q1sjr4 132 55 conformational conformational JJ cord-307853-m1q1sjr4 132 56 coordinates coordinate VBZ cord-307853-m1q1sjr4 132 57 basis basis NN cord-307853-m1q1sjr4 132 58 set set VBN cord-307853-m1q1sjr4 132 59 obtained obtain VBN cord-307853-m1q1sjr4 132 60 by by IN cord-307853-m1q1sjr4 132 61 the the DT cord-307853-m1q1sjr4 132 62 essential essential JJ cord-307853-m1q1sjr4 132 63 dynamics dynamic NNS cord-307853-m1q1sjr4 132 64 analysis analysis NN cord-307853-m1q1sjr4 132 65 of of IN cord-307853-m1q1sjr4 132 66 proteins protein NNS cord-307853-m1q1sjr4 132 67 ' ' POS cord-307853-m1q1sjr4 132 68 molecular molecular JJ cord-307853-m1q1sjr4 132 69 dynamics dynamic NNS cord-307853-m1q1sjr4 132 70 simulations simulation NNS cord-307853-m1q1sjr4 132 71 Convergence Convergence NNP cord-307853-m1q1sjr4 132 72 of of IN cord-307853-m1q1sjr4 132 73 sampling sampling NN cord-307853-m1q1sjr4 132 74 in in IN cord-307853-m1q1sjr4 132 75 protein protein NN cord-307853-m1q1sjr4 132 76 simulations simulation NNS cord-307853-m1q1sjr4 133 1 Cosine Cosine NNP cord-307853-m1q1sjr4 133 2 Similarity similarity NN cord-307853-m1q1sjr4 133 3 -an -an HYPH cord-307853-m1q1sjr4 133 4 overview overview NN cord-307853-m1q1sjr4 133 5 | | NNS cord-307853-m1q1sjr4 134 1 ScienceDirect ScienceDirect NNP cord-307853-m1q1sjr4 134 2 Topics topic NNS cord-307853-m1q1sjr4 135 1 ProDy ProDy NNP cord-307853-m1q1sjr4 135 2 : : : cord-307853-m1q1sjr4 135 3 Protein Protein NNP cord-307853-m1q1sjr4 135 4 Dynamics dynamic NNS cord-307853-m1q1sjr4 136 1 Inferred infer VBN cord-307853-m1q1sjr4 136 2 From from IN cord-307853-m1q1sjr4 136 3 Theory Theory NNP cord-307853-m1q1sjr4 136 4 and and CC cord-307853-m1q1sjr4 136 5 Experiments experiment NNS cord-307853-m1q1sjr4 137 1 -PubMed -PubMed NNP cord-307853-m1q1sjr4 137 2 Enhanced enhanced JJ cord-307853-m1q1sjr4 137 3 receptor receptor NN cord-307853-m1q1sjr4 137 4 binding binding NN cord-307853-m1q1sjr4 137 5 of of IN cord-307853-m1q1sjr4 137 6 SARS SARS NNP cord-307853-m1q1sjr4 137 7 - - HYPH cord-307853-m1q1sjr4 137 8 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 137 9 through through IN cord-307853-m1q1sjr4 137 10 networks network NNS cord-307853-m1q1sjr4 137 11 of of IN cord-307853-m1q1sjr4 137 12 hydrogen hydrogen NN cord-307853-m1q1sjr4 137 13 - - HYPH cord-307853-m1q1sjr4 137 14 bonding bonding NN cord-307853-m1q1sjr4 137 15 and and CC cord-307853-m1q1sjr4 137 16 hydrophobic hydrophobic JJ cord-307853-m1q1sjr4 137 17 interactions interaction NNS cord-307853-m1q1sjr4 137 18 Investigating investigate VBG cord-307853-m1q1sjr4 137 19 protein protein NN cord-307853-m1q1sjr4 137 20 dynamics dynamic NNS cord-307853-m1q1sjr4 137 21 in in IN cord-307853-m1q1sjr4 137 22 collective collective JJ cord-307853-m1q1sjr4 137 23 coordinate coordinate NN cord-307853-m1q1sjr4 137 24 space space NN cord-307853-m1q1sjr4 137 25 Anisotropic Anisotropic NNP cord-307853-m1q1sjr4 137 26 Network Network NNP cord-307853-m1q1sjr4 137 27 Model Model NNP cord-307853-m1q1sjr4 137 28 : : : cord-307853-m1q1sjr4 138 1 Systematic Systematic NNP cord-307853-m1q1sjr4 138 2 Evaluation Evaluation NNP cord-307853-m1q1sjr4 138 3 and and CC cord-307853-m1q1sjr4 138 4 a a DT cord-307853-m1q1sjr4 138 5 New New NNP cord-307853-m1q1sjr4 138 6 Web web NN cord-307853-m1q1sjr4 138 7 Interface interface NN cord-307853-m1q1sjr4 138 8 -PubMed -PubMed NNP cord-307853-m1q1sjr4 138 9 Phylogenetic Phylogenetic NNP cord-307853-m1q1sjr4 138 10 Analysis Analysis NNP cord-307853-m1q1sjr4 138 11 and and CC cord-307853-m1q1sjr4 138 12 Structural Structural NNP cord-307853-m1q1sjr4 138 13 Modeling Modeling NNP cord-307853-m1q1sjr4 138 14 of of IN cord-307853-m1q1sjr4 138 15 SARS SARS NNP cord-307853-m1q1sjr4 138 16 - - HYPH cord-307853-m1q1sjr4 138 17 CoV-2 CoV-2 NNP cord-307853-m1q1sjr4 138 18 Spike Spike NNP cord-307853-m1q1sjr4 138 19 Protein Protein NNP cord-307853-m1q1sjr4 138 20 Reveals reveal VBZ cord-307853-m1q1sjr4 138 21 an an DT cord-307853-m1q1sjr4 138 22 Evolutionary Evolutionary NNP cord-307853-m1q1sjr4 138 23 Distinct Distinct NNP cord-307853-m1q1sjr4 138 24 and and CC cord-307853-m1q1sjr4 138 25 Proteolytically Proteolytically NNP cord-307853-m1q1sjr4 138 26 Sensitive Sensitive NNP cord-307853-m1q1sjr4 138 27 Activation Activation NNP cord-307853-m1q1sjr4 138 28 Loop Loop NNP cord-307853-m1q1sjr4 139 1 This this DT cord-307853-m1q1sjr4 139 2 study study NN cord-307853-m1q1sjr4 139 3 was be VBD cord-307853-m1q1sjr4 139 4 supported support VBN cord-307853-m1q1sjr4 139 5 by by IN cord-307853-m1q1sjr4 139 6 FRPDF FRPDF NNP cord-307853-m1q1sjr4 139 7 grant grant NN cord-307853-m1q1sjr4 139 8 of of IN cord-307853-m1q1sjr4 139 9 Presidency Presidency NNP cord-307853-m1q1sjr4 139 10 University University NNP cord-307853-m1q1sjr4 139 11 . . . cord-307853-m1q1sjr4 140 1 Protocol protocol NN cord-307853-m1q1sjr4 140 2 designed design VBN cord-307853-m1q1sjr4 140 3 , , , cord-307853-m1q1sjr4 140 4 conceptualized conceptualize VBN cord-307853-m1q1sjr4 140 5 and and CC cord-307853-m1q1sjr4 140 6 analyzed analyze VBN cord-307853-m1q1sjr4 140 7 by by IN cord-307853-m1q1sjr4 140 8 S.M. S.M. NNP cord-307853-m1q1sjr4 140 9 , , , cord-307853-m1q1sjr4 140 10 manuscript manuscript NN cord-307853-m1q1sjr4 140 11 preparation preparation NN cord-307853-m1q1sjr4 140 12 done do VBN cord-307853-m1q1sjr4 140 13 by by IN cord-307853-m1q1sjr4 140 14 D.C. D.C. NNP cord-307853-m1q1sjr4 140 15 and and CC cord-307853-m1q1sjr4 140 16 J.D. J.D. NNP cord-307853-m1q1sjr4 140 17 Project Project NNP cord-307853-m1q1sjr4 140 18 was be VBD cord-307853-m1q1sjr4 140 19 done do VBN cord-307853-m1q1sjr4 140 20 under under IN cord-307853-m1q1sjr4 140 21 the the DT cord-307853-m1q1sjr4 140 22 supervision supervision NN cord-307853-m1q1sjr4 140 23 of of IN cord-307853-m1q1sjr4 140 24 K.G. K.G. NNP cord-307853-m1q1sjr4 141 1 The the DT cord-307853-m1q1sjr4 141 2 manuscript manuscript NN cord-307853-m1q1sjr4 141 3 was be VBD cord-307853-m1q1sjr4 141 4 reviewed review VBN cord-307853-m1q1sjr4 141 5 and and CC cord-307853-m1q1sjr4 141 6 approved approve VBN cord-307853-m1q1sjr4 141 7 by by IN cord-307853-m1q1sjr4 141 8 all all DT cord-307853-m1q1sjr4 141 9 authors author NNS cord-307853-m1q1sjr4 141 10 . . . cord-307853-m1q1sjr4 142 1 The the DT cord-307853-m1q1sjr4 142 2 authors author NNS cord-307853-m1q1sjr4 142 3 declare declare VBP cord-307853-m1q1sjr4 142 4 no no DT cord-307853-m1q1sjr4 142 5 conflict conflict NN cord-307853-m1q1sjr4 142 6 of of IN cord-307853-m1q1sjr4 142 7 interest interest NN cord-307853-m1q1sjr4 142 8 . . .