id sid tid token lemma pos cord-297652-ut6e1ysz 1 1 key key NN cord-297652-ut6e1ysz 1 2 : : : cord-297652-ut6e1ysz 1 3 cord-297652-ut6e1ysz cord-297652-ut6e1ysz NNP cord-297652-ut6e1ysz 1 4 authors author NNS cord-297652-ut6e1ysz 1 5 : : : cord-297652-ut6e1ysz 1 6 Vanden Vanden NNP cord-297652-ut6e1ysz 1 7 Eynde Eynde NNP cord-297652-ut6e1ysz 1 8 , , , cord-297652-ut6e1ysz 1 9 Jean Jean NNP cord-297652-ut6e1ysz 1 10 Jacques Jacques NNP cord-297652-ut6e1ysz 1 11 title title NN cord-297652-ut6e1ysz 1 12 : : : cord-297652-ut6e1ysz 2 1 COVID-19 covid-19 VB cord-297652-ut6e1ysz 2 2 : : : cord-297652-ut6e1ysz 2 3 A a DT cord-297652-ut6e1ysz 2 4 Brief Brief NNP cord-297652-ut6e1ysz 2 5 Overview Overview NNP cord-297652-ut6e1ysz 2 6 of of IN cord-297652-ut6e1ysz 2 7 the the DT cord-297652-ut6e1ysz 2 8 Discovery Discovery NNP cord-297652-ut6e1ysz 2 9 Clinical Clinical NNP cord-297652-ut6e1ysz 2 10 Trial Trial NNP cord-297652-ut6e1ysz 2 11 date date NN cord-297652-ut6e1ysz 2 12 : : : cord-297652-ut6e1ysz 2 13 2020 2020 CD cord-297652-ut6e1ysz 2 14 - - HYPH cord-297652-ut6e1ysz 2 15 04 04 CD cord-297652-ut6e1ysz 2 16 - - SYM cord-297652-ut6e1ysz 2 17 10 10 CD cord-297652-ut6e1ysz 2 18 journal journal NN cord-297652-ut6e1ysz 2 19 : : : cord-297652-ut6e1ysz 3 1 Pharmaceuticals pharmaceutical NNS cord-297652-ut6e1ysz 3 2 ( ( -LRB- cord-297652-ut6e1ysz 3 3 Basel Basel NNP cord-297652-ut6e1ysz 3 4 ) ) -RRB- cord-297652-ut6e1ysz 3 5 DOI DOI NNP cord-297652-ut6e1ysz 3 6 : : : cord-297652-ut6e1ysz 3 7 10.3390 10.3390 CD cord-297652-ut6e1ysz 3 8 / / SYM cord-297652-ut6e1ysz 3 9 ph13040065 ph13040065 NNP cord-297652-ut6e1ysz 3 10 sha sha NNP cord-297652-ut6e1ysz 3 11 : : : cord-297652-ut6e1ysz 3 12 9c4f2427952aeac0d4852c3a08e28b85fe2bf3dd 9c4f2427952aeac0d4852c3a08e28b85fe2bf3dd CD cord-297652-ut6e1ysz 3 13 doc_id doc_id CD cord-297652-ut6e1ysz 3 14 : : : cord-297652-ut6e1ysz 4 1 297652 297652 CD cord-297652-ut6e1ysz 4 2 cord_uid cord_uid NNS cord-297652-ut6e1ysz 4 3 : : : cord-297652-ut6e1ysz 5 1 ut6e1ysz ut6e1ysz NNP cord-297652-ut6e1ysz 6 1 The the DT cord-297652-ut6e1ysz 6 2 outbreak outbreak NN cord-297652-ut6e1ysz 6 3 of of IN cord-297652-ut6e1ysz 6 4 COVID-19 COVID-19 NNP cord-297652-ut6e1ysz 6 5 is be VBZ cord-297652-ut6e1ysz 6 6 leading lead VBG cord-297652-ut6e1ysz 6 7 to to IN cord-297652-ut6e1ysz 6 8 a a DT cord-297652-ut6e1ysz 6 9 tremendous tremendous JJ cord-297652-ut6e1ysz 6 10 search search NN cord-297652-ut6e1ysz 6 11 for for IN cord-297652-ut6e1ysz 6 12 curative curative JJ cord-297652-ut6e1ysz 6 13 treatments treatment NNS cord-297652-ut6e1ysz 6 14 . . . cord-297652-ut6e1ysz 7 1 The the DT cord-297652-ut6e1ysz 7 2 urgency urgency NN cord-297652-ut6e1ysz 7 3 of of IN cord-297652-ut6e1ysz 7 4 the the DT cord-297652-ut6e1ysz 7 5 situation situation NN cord-297652-ut6e1ysz 7 6 favors favor VBZ cord-297652-ut6e1ysz 7 7 a a DT cord-297652-ut6e1ysz 7 8 repurposing repurposing NN cord-297652-ut6e1ysz 7 9 of of IN cord-297652-ut6e1ysz 7 10 active active JJ cord-297652-ut6e1ysz 7 11 drugs drug NNS cord-297652-ut6e1ysz 7 12 but but CC cord-297652-ut6e1ysz 7 13 not not RB cord-297652-ut6e1ysz 7 14 only only RB cord-297652-ut6e1ysz 7 15 antivirals antiviral NNS cord-297652-ut6e1ysz 7 16 . . . cord-297652-ut6e1ysz 8 1 This this DT cord-297652-ut6e1ysz 8 2 short short JJ cord-297652-ut6e1ysz 8 3 communication communication NN cord-297652-ut6e1ysz 8 4 focuses focus VBZ cord-297652-ut6e1ysz 8 5 on on IN cord-297652-ut6e1ysz 8 6 four four CD cord-297652-ut6e1ysz 8 7 treatments treatment NNS cord-297652-ut6e1ysz 8 8 recommended recommend VBN cord-297652-ut6e1ysz 8 9 by by IN cord-297652-ut6e1ysz 8 10 WHO who WP cord-297652-ut6e1ysz 8 11 and and CC cord-297652-ut6e1ysz 8 12 included include VBN cord-297652-ut6e1ysz 8 13 in in IN cord-297652-ut6e1ysz 8 14 the the DT cord-297652-ut6e1ysz 8 15 first first JJ cord-297652-ut6e1ysz 8 16 clinical clinical JJ cord-297652-ut6e1ysz 8 17 trial trial NN cord-297652-ut6e1ysz 8 18 of of IN cord-297652-ut6e1ysz 8 19 the the DT cord-297652-ut6e1ysz 8 20 European European NNP cord-297652-ut6e1ysz 8 21 Discovery Discovery NNP cord-297652-ut6e1ysz 8 22 project project NN cord-297652-ut6e1ysz 8 23 . . . cord-297652-ut6e1ysz 9 1 COVID-19 COVID-19 NNP cord-297652-ut6e1ysz 9 2 ( ( -LRB- cord-297652-ut6e1ysz 9 3 coronavirus coronavirus NN cord-297652-ut6e1ysz 9 4 disease disease NN cord-297652-ut6e1ysz 9 5 2019 2019 CD cord-297652-ut6e1ysz 9 6 ) ) -RRB- cord-297652-ut6e1ysz 9 7 is be VBZ cord-297652-ut6e1ysz 9 8 a a DT cord-297652-ut6e1ysz 9 9 worldwide worldwide JJ cord-297652-ut6e1ysz 9 10 outbreak outbreak NN cord-297652-ut6e1ysz 9 11 of of IN cord-297652-ut6e1ysz 9 12 pneumonia pneumonia NN cord-297652-ut6e1ysz 9 13 and and CC cord-297652-ut6e1ysz 9 14 acute acute JJ cord-297652-ut6e1ysz 9 15 respiratory respiratory JJ cord-297652-ut6e1ysz 9 16 distress distress NN cord-297652-ut6e1ysz 9 17 syndrome syndrome NN cord-297652-ut6e1ysz 9 18 . . . cord-297652-ut6e1ysz 10 1 It -PRON- PRP cord-297652-ut6e1ysz 10 2 is be VBZ cord-297652-ut6e1ysz 10 3 unambiguously unambiguously RB cord-297652-ut6e1ysz 10 4 linked link VBN cord-297652-ut6e1ysz 10 5 to to IN cord-297652-ut6e1ysz 10 6 the the DT cord-297652-ut6e1ysz 10 7 human human JJ cord-297652-ut6e1ysz 10 8 - - HYPH cord-297652-ut6e1ysz 10 9 human human JJ cord-297652-ut6e1ysz 10 10 transmission transmission NN cord-297652-ut6e1ysz 10 11 of of IN cord-297652-ut6e1ysz 10 12 a a DT cord-297652-ut6e1ysz 10 13 novel novel JJ cord-297652-ut6e1ysz 10 14 coronavirus coronavirus NN cord-297652-ut6e1ysz 10 15 . . . cord-297652-ut6e1ysz 11 1 Mutagenomic mutagenomic JJ cord-297652-ut6e1ysz 11 2 analyses analyse VBZ cord-297652-ut6e1ysz 11 3 [ [ -LRB- cord-297652-ut6e1ysz 11 4 1 1 CD cord-297652-ut6e1ysz 11 5 ] ] -RRB- cord-297652-ut6e1ysz 11 6 demonstrated demonstrate VBD cord-297652-ut6e1ysz 11 7 that that IN cord-297652-ut6e1ysz 11 8 79.6 79.6 CD cord-297652-ut6e1ysz 11 9 % % NN cord-297652-ut6e1ysz 11 10 of of IN cord-297652-ut6e1ysz 11 11 the the DT cord-297652-ut6e1ysz 11 12 genome genome NN cord-297652-ut6e1ysz 11 13 sequences sequence NNS cord-297652-ut6e1ysz 11 14 were be VBD cord-297652-ut6e1ysz 11 15 identical identical JJ cord-297652-ut6e1ysz 11 16 to to IN cord-297652-ut6e1ysz 11 17 those those DT cord-297652-ut6e1ysz 11 18 found find VBN cord-297652-ut6e1ysz 11 19 in in IN cord-297652-ut6e1ysz 11 20 the the DT cord-297652-ut6e1ysz 11 21 coronavirus coronavirus NN cord-297652-ut6e1ysz 11 22 responsible responsible JJ cord-297652-ut6e1ysz 11 23 for for IN cord-297652-ut6e1ysz 11 24 the the DT cord-297652-ut6e1ysz 11 25 severe severe JJ cord-297652-ut6e1ysz 11 26 acute acute JJ cord-297652-ut6e1ysz 11 27 respiratory respiratory JJ cord-297652-ut6e1ysz 11 28 syndrome syndrome NN cord-297652-ut6e1ysz 11 29 ( ( -LRB- cord-297652-ut6e1ysz 11 30 SARS SARS NNP cord-297652-ut6e1ysz 11 31 ) ) -RRB- cord-297652-ut6e1ysz 11 32 , , , cord-297652-ut6e1ysz 11 33 which which WDT cord-297652-ut6e1ysz 11 34 spread spread VBD cord-297652-ut6e1ysz 11 35 in in IN cord-297652-ut6e1ysz 11 36 2002 2002 CD cord-297652-ut6e1ysz 11 37 . . . cord-297652-ut6e1ysz 12 1 Hence hence RB cord-297652-ut6e1ysz 12 2 the the DT cord-297652-ut6e1ysz 12 3 classification classification NN cord-297652-ut6e1ysz 12 4 as as IN cord-297652-ut6e1ysz 12 5 2019-nCoV 2019-ncov CD cord-297652-ut6e1ysz 12 6 ( ( -LRB- cord-297652-ut6e1ysz 12 7 n n NN cord-297652-ut6e1ysz 12 8 for for IN cord-297652-ut6e1ysz 12 9 novel novel NN cord-297652-ut6e1ysz 12 10 ) ) -RRB- cord-297652-ut6e1ysz 12 11 and and CC cord-297652-ut6e1ysz 12 12 the the DT cord-297652-ut6e1ysz 12 13 name name NN cord-297652-ut6e1ysz 12 14 SARS SARS NNP cord-297652-ut6e1ysz 12 15 - - HYPH cord-297652-ut6e1ysz 12 16 CoV-2 CoV-2 NNP cord-297652-ut6e1ysz 12 17 [ [ -LRB- cord-297652-ut6e1ysz 12 18 2 2 CD cord-297652-ut6e1ysz 12 19 ] ] -RRB- cord-297652-ut6e1ysz 12 20 . . . cord-297652-ut6e1ysz 13 1 Combatting combat VBG cord-297652-ut6e1ysz 13 2 SARS SARS NNP cord-297652-ut6e1ysz 13 3 - - HYPH cord-297652-ut6e1ysz 13 4 CoV-2 CoV-2 NNP cord-297652-ut6e1ysz 13 5 has have VBZ cord-297652-ut6e1ysz 13 6 emerged emerge VBN cord-297652-ut6e1ysz 13 7 as as IN cord-297652-ut6e1ysz 13 8 a a DT cord-297652-ut6e1ysz 13 9 tremendous tremendous JJ cord-297652-ut6e1ysz 13 10 challenge challenge NN cord-297652-ut6e1ysz 13 11 , , , cord-297652-ut6e1ysz 13 12 gathering gather VBG cord-297652-ut6e1ysz 13 13 efforts effort NNS cord-297652-ut6e1ysz 13 14 from from IN cord-297652-ut6e1ysz 13 15 academia academia NN cord-297652-ut6e1ysz 13 16 , , , cord-297652-ut6e1ysz 13 17 pharmaceutical pharmaceutical NN cord-297652-ut6e1ysz 13 18 companies company NNS cord-297652-ut6e1ysz 13 19 , , , cord-297652-ut6e1ysz 13 20 hospitals hospital NNS cord-297652-ut6e1ysz 13 21 , , , cord-297652-ut6e1ysz 13 22 international international JJ cord-297652-ut6e1ysz 13 23 organizations organization NNS cord-297652-ut6e1ysz 13 24 , , , cord-297652-ut6e1ysz 13 25 as as RB cord-297652-ut6e1ysz 13 26 well well RB cord-297652-ut6e1ysz 13 27 as as IN cord-297652-ut6e1ysz 13 28 governments government NNS cord-297652-ut6e1ysz 13 29 and and CC cord-297652-ut6e1ysz 13 30 philanthropic philanthropic JJ cord-297652-ut6e1ysz 13 31 associations association NNS cord-297652-ut6e1ysz 13 32 ( ( -LRB- cord-297652-ut6e1ysz 13 33 e.g. e.g. RB cord-297652-ut6e1ysz 13 34 , , , cord-297652-ut6e1ysz 13 35 The the DT cord-297652-ut6e1ysz 13 36 Council Council NNP cord-297652-ut6e1ysz 13 37 on on IN cord-297652-ut6e1ysz 13 38 Foundations Foundations NNPS cord-297652-ut6e1ysz 13 39 [ [ -LRB- cord-297652-ut6e1ysz 13 40 3 3 CD cord-297652-ut6e1ysz 13 41 ] ] -RRB- cord-297652-ut6e1ysz 13 42 ) ) -RRB- cord-297652-ut6e1ysz 13 43 . . . cord-297652-ut6e1ysz 14 1 In in IN cord-297652-ut6e1ysz 14 2 this this DT cord-297652-ut6e1ysz 14 3 Opinion opinion NN cord-297652-ut6e1ysz 14 4 , , , cord-297652-ut6e1ysz 14 5 we -PRON- PRP cord-297652-ut6e1ysz 14 6 give give VBP cord-297652-ut6e1ysz 14 7 a a DT cord-297652-ut6e1ysz 14 8 brief brief JJ cord-297652-ut6e1ysz 14 9 overview overview NN cord-297652-ut6e1ysz 14 10 of of IN cord-297652-ut6e1ysz 14 11 some some DT cord-297652-ut6e1ysz 14 12 current current JJ cord-297652-ut6e1ysz 14 13 and and CC cord-297652-ut6e1ysz 14 14 future future JJ cord-297652-ut6e1ysz 14 15 clinical clinical JJ cord-297652-ut6e1ysz 14 16 trials trial NNS cord-297652-ut6e1ysz 14 17 , , , cord-297652-ut6e1ysz 14 18 as as IN cord-297652-ut6e1ysz 14 19 they -PRON- PRP cord-297652-ut6e1ysz 14 20 can can MD cord-297652-ut6e1ysz 14 21 be be VB cord-297652-ut6e1ysz 14 22 found find VBN cord-297652-ut6e1ysz 14 23 in in IN cord-297652-ut6e1ysz 14 24 the the DT cord-297652-ut6e1ysz 14 25 U.S. U.S. NNP cord-297652-ut6e1ysz 14 26 National National NNP cord-297652-ut6e1ysz 14 27 Library Library NNP cord-297652-ut6e1ysz 14 28 of of IN cord-297652-ut6e1ysz 14 29 Medicine Medicine NNP cord-297652-ut6e1ysz 14 30 of of IN cord-297652-ut6e1ysz 14 31 the the DT cord-297652-ut6e1ysz 14 32 National National NNP cord-297652-ut6e1ysz 14 33 Institutes Institutes NNPS cord-297652-ut6e1ysz 14 34 of of IN cord-297652-ut6e1ysz 14 35 Health Health NNP cord-297652-ut6e1ysz 14 36 ( ( -LRB- cord-297652-ut6e1ysz 14 37 Bethesda Bethesda NNP cord-297652-ut6e1ysz 14 38 , , , cord-297652-ut6e1ysz 14 39 MD MD NNP cord-297652-ut6e1ysz 14 40 , , , cord-297652-ut6e1ysz 14 41 USA USA NNP cord-297652-ut6e1ysz 14 42 ) ) -RRB- cord-297652-ut6e1ysz 14 43 [ [ -LRB- cord-297652-ut6e1ysz 14 44 4 4 CD cord-297652-ut6e1ysz 14 45 ] ] -RRB- cord-297652-ut6e1ysz 14 46 . . . cord-297652-ut6e1ysz 15 1 As as IN cord-297652-ut6e1ysz 15 2 of of IN cord-297652-ut6e1ysz 15 3 March March NNP cord-297652-ut6e1ysz 15 4 28 28 CD cord-297652-ut6e1ysz 15 5 , , , cord-297652-ut6e1ysz 15 6 202 202 CD cord-297652-ut6e1ysz 15 7 clinical clinical JJ cord-297652-ut6e1ysz 15 8 trials trial NNS cord-297652-ut6e1ysz 15 9 could could MD cord-297652-ut6e1ysz 15 10 be be VB cord-297652-ut6e1ysz 15 11 retrieved retrieve VBN cord-297652-ut6e1ysz 15 12 with with IN cord-297652-ut6e1ysz 15 13 the the DT cord-297652-ut6e1ysz 15 14 search search NN cord-297652-ut6e1ysz 15 15 term term NN cord-297652-ut6e1ysz 15 16 " " '' cord-297652-ut6e1ysz 15 17 COVID- covid- NN cord-297652-ut6e1ysz 15 18 19 19 CD cord-297652-ut6e1ysz 15 19 More More JJR cord-297652-ut6e1ysz 15 20 than than IN cord-297652-ut6e1ysz 15 21 100 100 CD cord-297652-ut6e1ysz 15 22 studies study NNS cord-297652-ut6e1ysz 15 23 involving involve VBG cord-297652-ut6e1ysz 15 24 other other JJ cord-297652-ut6e1ysz 15 25 small small JJ cord-297652-ut6e1ysz 15 26 molecules molecule NNS cord-297652-ut6e1ysz 15 27 . . . cord-297652-ut6e1ysz 16 1 A a DT cord-297652-ut6e1ysz 16 2 quick quick JJ cord-297652-ut6e1ysz 16 3 reading reading NN cord-297652-ut6e1ysz 16 4 of of IN cord-297652-ut6e1ysz 16 5 these these DT cord-297652-ut6e1ysz 16 6 projects project NNS cord-297652-ut6e1ysz 16 7 [ [ -LRB- cord-297652-ut6e1ysz 16 8 4 4 CD cord-297652-ut6e1ysz 16 9 ] ] -RRB- cord-297652-ut6e1ysz 16 10 allows allow VBZ cord-297652-ut6e1ysz 16 11 one one PRP cord-297652-ut6e1ysz 16 12 to to TO cord-297652-ut6e1ysz 16 13 sort sort VB cord-297652-ut6e1ysz 16 14 out out RP cord-297652-ut6e1ysz 16 15 the the DT cord-297652-ut6e1ysz 16 16 monoclonal monoclonal JJ cord-297652-ut6e1ysz 16 17 antibodies antibody NNS cord-297652-ut6e1ysz 16 18 , , , cord-297652-ut6e1ysz 16 19 antiviral antiviral JJ cord-297652-ut6e1ysz 16 20 drugs drug NNS cord-297652-ut6e1ysz 16 21 , , , cord-297652-ut6e1ysz 16 22 and and CC cord-297652-ut6e1ysz 16 23 other other JJ cord-297652-ut6e1ysz 16 24 small small JJ cord-297652-ut6e1ysz 16 25 molecules molecule NNS cord-297652-ut6e1ysz 16 26 that that WDT cord-297652-ut6e1ysz 16 27 are be VBP cord-297652-ut6e1ysz 16 28 most most RBS cord-297652-ut6e1ysz 16 29 cited cite VBN cord-297652-ut6e1ysz 16 30 in in IN cord-297652-ut6e1ysz 16 31 the the DT cord-297652-ut6e1ysz 16 32 trials trial NNS cord-297652-ut6e1ysz 16 33 . . . cord-297652-ut6e1ysz 17 1 The the DT cord-297652-ut6e1ysz 17 2 list list NN cord-297652-ut6e1ysz 17 3 can can MD cord-297652-ut6e1ysz 17 4 be be VB cord-297652-ut6e1ysz 17 5 found find VBN cord-297652-ut6e1ysz 17 6 in in IN cord-297652-ut6e1ysz 17 7 Table Table NNP cord-297652-ut6e1ysz 17 8 1 1 CD cord-297652-ut6e1ysz 17 9 . . . cord-297652-ut6e1ysz 17 10 _SP cord-297652-ut6e1ysz 18 1 On on IN cord-297652-ut6e1ysz 18 2 March March NNP cord-297652-ut6e1ysz 18 3 13 13 CD cord-297652-ut6e1ysz 18 4 , , , cord-297652-ut6e1ysz 18 5 the the DT cord-297652-ut6e1ysz 18 6 United United NNP cord-297652-ut6e1ysz 18 7 Nations Nations NNP cord-297652-ut6e1ysz 18 8 Foundation Foundation NNP cord-297652-ut6e1ysz 18 9 , , , cord-297652-ut6e1ysz 18 10 the the DT cord-297652-ut6e1ysz 18 11 Swiss Swiss NNP cord-297652-ut6e1ysz 18 12 Philanthropy Philanthropy NNP cord-297652-ut6e1ysz 18 13 Foundation Foundation NNP cord-297652-ut6e1ysz 18 14 , , , cord-297652-ut6e1ysz 18 15 and and CC cord-297652-ut6e1ysz 18 16 the the DT cord-297652-ut6e1ysz 18 17 World World NNP cord-297652-ut6e1ysz 18 18 Health Health NNP cord-297652-ut6e1ysz 18 19 Organization Organization NNP cord-297652-ut6e1ysz 18 20 ( ( -LRB- cord-297652-ut6e1ysz 18 21 WHO who WP cord-297652-ut6e1ysz 18 22 ) ) -RRB- cord-297652-ut6e1ysz 18 23 have have VBP cord-297652-ut6e1ysz 18 24 created create VBN cord-297652-ut6e1ysz 18 25 the the DT cord-297652-ut6e1ysz 18 26 SOLIDARITY SOLIDARITY NNP cord-297652-ut6e1ysz 18 27 Response Response NNP cord-297652-ut6e1ysz 18 28 Fund Fund NNP cord-297652-ut6e1ysz 18 29 in in IN cord-297652-ut6e1ysz 18 30 order order NN cord-297652-ut6e1ysz 18 31 to to TO cord-297652-ut6e1ysz 18 32 raise raise VB cord-297652-ut6e1ysz 18 33 money money NN cord-297652-ut6e1ysz 18 34 to to TO cord-297652-ut6e1ysz 18 35 support support VB cord-297652-ut6e1ysz 18 36 studies study NNS cord-297652-ut6e1ysz 18 37 on on IN cord-297652-ut6e1ysz 18 38 COVID-19 COVID-19 NNP cord-297652-ut6e1ysz 18 39 [ [ -LRB- cord-297652-ut6e1ysz 18 40 5 5 CD cord-297652-ut6e1ysz 18 41 ] ] -RRB- cord-297652-ut6e1ysz 18 42 . . . cord-297652-ut6e1ysz 19 1 On on IN cord-297652-ut6e1ysz 19 2 March March NNP cord-297652-ut6e1ysz 19 3 18 18 CD cord-297652-ut6e1ysz 19 4 , , , cord-297652-ut6e1ysz 19 5 WHO who WP cord-297652-ut6e1ysz 19 6 indicated indicate VBD cord-297652-ut6e1ysz 19 7 that that IN cord-297652-ut6e1ysz 19 8 the the DT cord-297652-ut6e1ysz 19 9 first first JJ cord-297652-ut6e1ysz 19 10 trial trial NN cord-297652-ut6e1ysz 19 11 supported support VBN cord-297652-ut6e1ysz 19 12 by by IN cord-297652-ut6e1ysz 19 13 the the DT cord-297652-ut6e1ysz 19 14 Fund Fund NNP cord-297652-ut6e1ysz 19 15 would would MD cord-297652-ut6e1ysz 19 16 be be VB cord-297652-ut6e1ysz 19 17 an an DT cord-297652-ut6e1ysz 19 18 adaptative adaptative JJ cord-297652-ut6e1ysz 19 19 study study NN cord-297652-ut6e1ysz 19 20 performed perform VBN cord-297652-ut6e1ysz 19 21 in in IN cord-297652-ut6e1ysz 19 22 ten ten CD cord-297652-ut6e1ysz 19 23 countries country NNS cord-297652-ut6e1ysz 19 24 , , , cord-297652-ut6e1ysz 19 25 namely namely RB cord-297652-ut6e1ysz 19 26 Argentina Argentina NNP cord-297652-ut6e1ysz 19 27 , , , cord-297652-ut6e1ysz 19 28 Bahrain Bahrain NNP cord-297652-ut6e1ysz 19 29 , , , cord-297652-ut6e1ysz 19 30 Canada Canada NNP cord-297652-ut6e1ysz 19 31 , , , cord-297652-ut6e1ysz 19 32 France France NNP cord-297652-ut6e1ysz 19 33 , , , cord-297652-ut6e1ysz 19 34 Iran Iran NNP cord-297652-ut6e1ysz 19 35 , , , cord-297652-ut6e1ysz 19 36 Norway Norway NNP cord-297652-ut6e1ysz 19 37 , , , cord-297652-ut6e1ysz 19 38 South South NNP cord-297652-ut6e1ysz 19 39 Africa Africa NNP cord-297652-ut6e1ysz 19 40 , , , cord-297652-ut6e1ysz 19 41 Spain Spain NNP cord-297652-ut6e1ysz 19 42 , , , cord-297652-ut6e1ysz 19 43 Switzerland Switzerland NNP cord-297652-ut6e1ysz 19 44 , , , cord-297652-ut6e1ysz 19 45 Thailand Thailand NNP cord-297652-ut6e1ysz 19 46 . . . cord-297652-ut6e1ysz 20 1 India India NNP cord-297652-ut6e1ysz 20 2 joined join VBD cord-297652-ut6e1ysz 20 3 the the DT cord-297652-ut6e1ysz 20 4 trial trial NN cord-297652-ut6e1ysz 20 5 on on IN cord-297652-ut6e1ysz 20 6 March March NNP cord-297652-ut6e1ysz 20 7 27 27 CD cord-297652-ut6e1ysz 20 8 . . . cord-297652-ut6e1ysz 21 1 On on IN cord-297652-ut6e1ysz 21 2 March March NNP cord-297652-ut6e1ysz 21 3 22 22 CD cord-297652-ut6e1ysz 21 4 , , , cord-297652-ut6e1ysz 21 5 the the DT cord-297652-ut6e1ysz 21 6 French french JJ cord-297652-ut6e1ysz 21 7 Institut Institut NNP cord-297652-ut6e1ysz 21 8 National National NNP cord-297652-ut6e1ysz 21 9 de de NNP cord-297652-ut6e1ysz 21 10 la la FW cord-297652-ut6e1ysz 21 11 Santé Santé NNP cord-297652-ut6e1ysz 21 12 Et Et NNP cord-297652-ut6e1ysz 21 13 de de FW cord-297652-ut6e1ysz 21 14 la la FW cord-297652-ut6e1ysz 21 15 Recherche Recherche NNP cord-297652-ut6e1ysz 21 16 Médicale Médicale NNP cord-297652-ut6e1ysz 21 17 ( ( -LRB- cord-297652-ut6e1ysz 21 18 INSERM INSERM NNP cord-297652-ut6e1ysz 21 19 ) ) -RRB- cord-297652-ut6e1ysz 21 20 announced announce VBD cord-297652-ut6e1ysz 21 21 a a DT cord-297652-ut6e1ysz 21 22 European european JJ cord-297652-ut6e1ysz 21 23 counterpart counterpart NN cord-297652-ut6e1ysz 21 24 , , , cord-297652-ut6e1ysz 21 25 named name VBN cord-297652-ut6e1ysz 21 26 Discovery Discovery NNP cord-297652-ut6e1ysz 21 27 , , , cord-297652-ut6e1ysz 21 28 and and CC cord-297652-ut6e1ysz 21 29 aimed aim VBN cord-297652-ut6e1ysz 21 30 at at IN cord-297652-ut6e1ysz 21 31 a a DT cord-297652-ut6e1ysz 21 32 study study NN cord-297652-ut6e1ysz 21 33 of of IN cord-297652-ut6e1ysz 21 34 four four CD cord-297652-ut6e1ysz 21 35 treatments treatment NNS cord-297652-ut6e1ysz 21 36 on on IN cord-297652-ut6e1ysz 21 37 3100 3100 CD cord-297652-ut6e1ysz 21 38 patients patient NNS cord-297652-ut6e1ysz 21 39 in in IN cord-297652-ut6e1ysz 21 40 seven seven CD cord-297652-ut6e1ysz 21 41 countries country NNS cord-297652-ut6e1ysz 21 42 , , , cord-297652-ut6e1ysz 21 43 namely namely RB cord-297652-ut6e1ysz 21 44 France France NNP cord-297652-ut6e1ysz 21 45 , , , cord-297652-ut6e1ysz 21 46 Spain Spain NNP cord-297652-ut6e1ysz 21 47 , , , cord-297652-ut6e1ysz 21 48 the the DT cord-297652-ut6e1ysz 21 49 United United NNP cord-297652-ut6e1ysz 21 50 Kingdom Kingdom NNP cord-297652-ut6e1ysz 21 51 , , , cord-297652-ut6e1ysz 21 52 Germany Germany NNP cord-297652-ut6e1ysz 21 53 , , , cord-297652-ut6e1ysz 21 54 Luxembourg Luxembourg NNP cord-297652-ut6e1ysz 21 55 , , , cord-297652-ut6e1ysz 21 56 the the DT cord-297652-ut6e1ysz 21 57 Netherlands Netherlands NNP cord-297652-ut6e1ysz 21 58 , , , cord-297652-ut6e1ysz 21 59 and and CC cord-297652-ut6e1ysz 21 60 Belgium Belgium NNP cord-297652-ut6e1ysz 21 61 [ [ -LRB- cord-297652-ut6e1ysz 21 62 6 6 CD cord-297652-ut6e1ysz 21 63 ] ] -RRB- cord-297652-ut6e1ysz 21 64 . . . cord-297652-ut6e1ysz 22 1 The the DT cord-297652-ut6e1ysz 22 2 four four CD cord-297652-ut6e1ysz 22 3 treatments treatment NNS cord-297652-ut6e1ysz 22 4 to to TO cord-297652-ut6e1ysz 22 5 be be VB cord-297652-ut6e1ysz 22 6 analyzed analyze VBN cord-297652-ut6e1ysz 22 7 are be VBP cord-297652-ut6e1ysz 22 8 : : : cord-297652-ut6e1ysz 22 9 The the DT cord-297652-ut6e1ysz 22 10 combination combination NN cord-297652-ut6e1ysz 22 11 lopinavir lopinavir NNS cord-297652-ut6e1ysz 22 12 / / SYM cord-297652-ut6e1ysz 22 13 ritonavir ritonavir NNS cord-297652-ut6e1ysz 22 14 ; ; : cord-297652-ut6e1ysz 22 15 • • NNP cord-297652-ut6e1ysz 23 1 The the DT cord-297652-ut6e1ysz 23 2 combination combination NN cord-297652-ut6e1ysz 23 3 lopinavir lopinavir NNS cord-297652-ut6e1ysz 23 4 / / SYM cord-297652-ut6e1ysz 23 5 ritonavir ritonavir NNS cord-297652-ut6e1ysz 23 6 with with IN cord-297652-ut6e1ysz 23 7 the the DT cord-297652-ut6e1ysz 23 8 addition addition NN cord-297652-ut6e1ysz 23 9 of of IN cord-297652-ut6e1ysz 23 10 interferon interferon NNP cord-297652-ut6e1ysz 23 11 β-1a β-1a NNP cord-297652-ut6e1ysz 23 12 ; ; : cord-297652-ut6e1ysz 23 13 • • NNP cord-297652-ut6e1ysz 23 14 Hydroxychloroquine Hydroxychloroquine NNP cord-297652-ut6e1ysz 23 15 , , , cord-297652-ut6e1ysz 23 16 eventually eventually RB cord-297652-ut6e1ysz 23 17 associated associate VBN cord-297652-ut6e1ysz 23 18 with with IN cord-297652-ut6e1ysz 23 19 an an DT cord-297652-ut6e1ysz 23 20 antibiotic antibiotic NN cord-297652-ut6e1ysz 23 21 ( ( -LRB- cord-297652-ut6e1ysz 23 22 azithromycin azithromycin NN cord-297652-ut6e1ysz 23 23 ) ) -RRB- cord-297652-ut6e1ysz 23 24 in in IN cord-297652-ut6e1ysz 23 25 add add NN cord-297652-ut6e1ysz 23 26 - - HYPH cord-297652-ut6e1ysz 23 27 on on RP cord-297652-ut6e1ysz 23 28 studies study NNS cord-297652-ut6e1ysz 23 29 . . . cord-297652-ut6e1ysz 24 1 The the DT cord-297652-ut6e1ysz 24 2 study study NN cord-297652-ut6e1ysz 24 3 is be VBZ cord-297652-ut6e1ysz 24 4 entitled entitle VBN cord-297652-ut6e1ysz 24 5 " " `` cord-297652-ut6e1ysz 24 6 Trial Trial NNP cord-297652-ut6e1ysz 24 7 of of IN cord-297652-ut6e1ysz 24 8 Treatments Treatments NNPS cord-297652-ut6e1ysz 24 9 for for IN cord-297652-ut6e1ysz 24 10 COVID-19 covid-19 CD cord-297652-ut6e1ysz 24 11 in in IN cord-297652-ut6e1ysz 24 12 Hospitalized Hospitalized NNP cord-297652-ut6e1ysz 24 13 Adults Adults NNPS cord-297652-ut6e1ysz 24 14 ( ( -LRB- cord-297652-ut6e1ysz 24 15 DisCoVeRy DisCoVeRy NNP cord-297652-ut6e1ysz 24 16 ) ) -RRB- cord-297652-ut6e1ysz 24 17 " " '' cord-297652-ut6e1ysz 24 18 ( ( -LRB- cord-297652-ut6e1ysz 24 19 NCT04315948 NCT04315948 NNP cord-297652-ut6e1ysz 24 20 ) ) -RRB- cord-297652-ut6e1ysz 24 21 [ [ -LRB- cord-297652-ut6e1ysz 24 22 4 4 CD cord-297652-ut6e1ysz 24 23 ] ] -RRB- cord-297652-ut6e1ysz 24 24 . . . cord-297652-ut6e1ysz 25 1 It -PRON- PRP cord-297652-ut6e1ysz 25 2 started start VBD cord-297652-ut6e1ysz 25 3 in in IN cord-297652-ut6e1ysz 25 4 three three CD cord-297652-ut6e1ysz 25 5 French french JJ cord-297652-ut6e1ysz 25 6 hospitals hospital NNS cord-297652-ut6e1ysz 25 7 : : : cord-297652-ut6e1ysz 25 8 Centre Centre NNP cord-297652-ut6e1ysz 25 9 Hospitalier Hospitalier NNP cord-297652-ut6e1ysz 25 10 Régional Régional NNP cord-297652-ut6e1ysz 25 11 Universitaire Universitaire NNP cord-297652-ut6e1ysz 25 12 de de FW cord-297652-ut6e1ysz 25 13 Lille Lille NNP cord-297652-ut6e1ysz 25 14 ( ( -LRB- cord-297652-ut6e1ysz 25 15 Lille Lille NNP cord-297652-ut6e1ysz 25 16 , , , cord-297652-ut6e1ysz 25 17 France France NNP cord-297652-ut6e1ysz 25 18 ) ) -RRB- cord-297652-ut6e1ysz 25 19 , , , cord-297652-ut6e1ysz 25 20 Centre Centre NNP cord-297652-ut6e1ysz 25 21 Hospitalier Hospitalier NNP cord-297652-ut6e1ysz 25 22 Universitaire Universitaire NNP cord-297652-ut6e1ysz 25 23 de de IN cord-297652-ut6e1ysz 25 24 Nantes Nantes NNP cord-297652-ut6e1ysz 25 25 ( ( -LRB- cord-297652-ut6e1ysz 25 26 Nantes Nantes NNP cord-297652-ut6e1ysz 25 27 , , , cord-297652-ut6e1ysz 25 28 France France NNP cord-297652-ut6e1ysz 25 29 ) ) -RRB- cord-297652-ut6e1ysz 25 30 , , , cord-297652-ut6e1ysz 25 31 and and CC cord-297652-ut6e1ysz 25 32 Assistance Assistance NNP cord-297652-ut6e1ysz 25 33 Publique Publique NNP cord-297652-ut6e1ysz 25 34 Hôpitaux Hôpitaux NNP cord-297652-ut6e1ysz 25 35 de de NNP cord-297652-ut6e1ysz 25 36 Paris Paris NNP cord-297652-ut6e1ysz 26 1 -Bichat -bichat WDT cord-297652-ut6e1ysz 26 2 Claude Claude NNP cord-297652-ut6e1ysz 26 3 Bernard Bernard NNP cord-297652-ut6e1ysz 26 4 ( ( -LRB- cord-297652-ut6e1ysz 26 5 Paris Paris NNP cord-297652-ut6e1ysz 26 6 , , , cord-297652-ut6e1ysz 26 7 France France NNP cord-297652-ut6e1ysz 26 8 ) ) -RRB- cord-297652-ut6e1ysz 26 9 . . . cord-297652-ut6e1ysz 27 1 The the DT cord-297652-ut6e1ysz 27 2 structure structure NN cord-297652-ut6e1ysz 27 3 and and CC cord-297652-ut6e1ysz 27 4 some some DT cord-297652-ut6e1ysz 27 5 characteristics characteristic NNS cord-297652-ut6e1ysz 27 6 of of IN cord-297652-ut6e1ysz 27 7 the the DT cord-297652-ut6e1ysz 27 8 four four CD cord-297652-ut6e1ysz 27 9 small small JJ cord-297652-ut6e1ysz 27 10 molecules molecule NNS cord-297652-ut6e1ysz 27 11 involved involve VBN cord-297652-ut6e1ysz 27 12 in in IN cord-297652-ut6e1ysz 27 13 that that DT cord-297652-ut6e1ysz 27 14 clinical clinical JJ cord-297652-ut6e1ysz 27 15 trial trial NN cord-297652-ut6e1ysz 27 16 are be VBP cord-297652-ut6e1ysz 27 17 collected collect VBN cord-297652-ut6e1ysz 27 18 in in IN cord-297652-ut6e1ysz 27 19 Figure figure NN cord-297652-ut6e1ysz 27 20 1 1 CD cord-297652-ut6e1ysz 27 21 . . . cord-297652-ut6e1ysz 28 1 The the DT cord-297652-ut6e1ysz 28 2 formula formula NN cord-297652-ut6e1ysz 28 3 of of IN cord-297652-ut6e1ysz 28 4 chloroquine chloroquine NN cord-297652-ut6e1ysz 28 5 is be VBZ cord-297652-ut6e1ysz 28 6 added add VBN cord-297652-ut6e1ysz 28 7 for for IN cord-297652-ut6e1ysz 28 8 comparison comparison NN cord-297652-ut6e1ysz 28 9 . . . cord-297652-ut6e1ysz 29 1 Lille Lille NNP cord-297652-ut6e1ysz 29 2 ( ( -LRB- cord-297652-ut6e1ysz 29 3 Lille Lille NNP cord-297652-ut6e1ysz 29 4 , , , cord-297652-ut6e1ysz 29 5 France France NNP cord-297652-ut6e1ysz 29 6 ) ) -RRB- cord-297652-ut6e1ysz 29 7 , , , cord-297652-ut6e1ysz 29 8 Centre Centre NNP cord-297652-ut6e1ysz 29 9 Hospitalier Hospitalier NNP cord-297652-ut6e1ysz 29 10 Universitaire Universitaire NNP cord-297652-ut6e1ysz 29 11 de de IN cord-297652-ut6e1ysz 29 12 Nantes Nantes NNP cord-297652-ut6e1ysz 29 13 ( ( -LRB- cord-297652-ut6e1ysz 29 14 Nantes Nantes NNP cord-297652-ut6e1ysz 29 15 , , , cord-297652-ut6e1ysz 29 16 France France NNP cord-297652-ut6e1ysz 29 17 ) ) -RRB- cord-297652-ut6e1ysz 29 18 , , , cord-297652-ut6e1ysz 29 19 and and CC cord-297652-ut6e1ysz 29 20 Assistance Assistance NNP cord-297652-ut6e1ysz 29 21 Publique Publique NNP cord-297652-ut6e1ysz 29 22 Hôpitaux Hôpitaux NNP cord-297652-ut6e1ysz 29 23 de de NNP cord-297652-ut6e1ysz 29 24 Paris Paris NNP cord-297652-ut6e1ysz 30 1 -Bichat -bichat WDT cord-297652-ut6e1ysz 30 2 Claude Claude NNP cord-297652-ut6e1ysz 30 3 Bernard Bernard NNP cord-297652-ut6e1ysz 30 4 ( ( -LRB- cord-297652-ut6e1ysz 30 5 Paris Paris NNP cord-297652-ut6e1ysz 30 6 , , , cord-297652-ut6e1ysz 30 7 France France NNP cord-297652-ut6e1ysz 30 8 ) ) -RRB- cord-297652-ut6e1ysz 30 9 . . . cord-297652-ut6e1ysz 31 1 The the DT cord-297652-ut6e1ysz 31 2 structure structure NN cord-297652-ut6e1ysz 31 3 and and CC cord-297652-ut6e1ysz 31 4 some some DT cord-297652-ut6e1ysz 31 5 characteristics characteristic NNS cord-297652-ut6e1ysz 31 6 of of IN cord-297652-ut6e1ysz 31 7 the the DT cord-297652-ut6e1ysz 31 8 four four CD cord-297652-ut6e1ysz 31 9 small small JJ cord-297652-ut6e1ysz 31 10 molecules molecule NNS cord-297652-ut6e1ysz 31 11 involved involve VBN cord-297652-ut6e1ysz 31 12 in in IN cord-297652-ut6e1ysz 31 13 that that DT cord-297652-ut6e1ysz 31 14 clinical clinical JJ cord-297652-ut6e1ysz 31 15 trial trial NN cord-297652-ut6e1ysz 31 16 are be VBP cord-297652-ut6e1ysz 31 17 collected collect VBN cord-297652-ut6e1ysz 31 18 in in IN cord-297652-ut6e1ysz 31 19 Figure figure NN cord-297652-ut6e1ysz 31 20 1 1 CD cord-297652-ut6e1ysz 31 21 . . . cord-297652-ut6e1ysz 32 1 The the DT cord-297652-ut6e1ysz 32 2 formula formula NN cord-297652-ut6e1ysz 32 3 of of IN cord-297652-ut6e1ysz 32 4 chloroquine chloroquine NN cord-297652-ut6e1ysz 32 5 is be VBZ cord-297652-ut6e1ysz 32 6 added add VBN cord-297652-ut6e1ysz 32 7 for for IN cord-297652-ut6e1ysz 32 8 comparison comparison NN cord-297652-ut6e1ysz 32 9 . . . cord-297652-ut6e1ysz 32 10 _SP cord-297652-ut6e1ysz 33 1 It -PRON- PRP cord-297652-ut6e1ysz 33 2 has have VBZ cord-297652-ut6e1ysz 33 3 been be VBN cord-297652-ut6e1ysz 33 4 announced announce VBN cord-297652-ut6e1ysz 33 5 that that IN cord-297652-ut6e1ysz 33 6 the the DT cord-297652-ut6e1ysz 33 7 Discovery Discovery NNP cord-297652-ut6e1ysz 33 8 project project NN cord-297652-ut6e1ysz 33 9 is be VBZ cord-297652-ut6e1ysz 33 10 an an DT cord-297652-ut6e1ysz 33 11 adaptive adaptive JJ cord-297652-ut6e1ysz 33 12 study study NN cord-297652-ut6e1ysz 33 13 . . . cord-297652-ut6e1ysz 34 1 That that DT cord-297652-ut6e1ysz 34 2 means mean VBZ cord-297652-ut6e1ysz 34 3 that that IN cord-297652-ut6e1ysz 34 4 some some DT cord-297652-ut6e1ysz 34 5 treatments treatment NNS cord-297652-ut6e1ysz 34 6 can can MD cord-297652-ut6e1ysz 34 7 be be VB cord-297652-ut6e1ysz 34 8 abandoned abandon VBN cord-297652-ut6e1ysz 34 9 during during IN cord-297652-ut6e1ysz 34 10 the the DT cord-297652-ut6e1ysz 34 11 study study NN cord-297652-ut6e1ysz 34 12 if if IN cord-297652-ut6e1ysz 34 13 results result NNS cord-297652-ut6e1ysz 34 14 are be VBP cord-297652-ut6e1ysz 34 15 not not RB cord-297652-ut6e1ysz 34 16 encouraging encouraging JJ cord-297652-ut6e1ysz 34 17 , , , cord-297652-ut6e1ysz 34 18 whereas whereas IN cord-297652-ut6e1ysz 34 19 new new JJ cord-297652-ut6e1ysz 34 20 treatments treatment NNS cord-297652-ut6e1ysz 34 21 could could MD cord-297652-ut6e1ysz 34 22 be be VB cord-297652-ut6e1ysz 34 23 added add VBN cord-297652-ut6e1ysz 34 24 . . . cord-297652-ut6e1ysz 35 1 Some some DT cord-297652-ut6e1ysz 35 2 noticeable noticeable JJ cord-297652-ut6e1ysz 35 3 characteristics characteristic NNS cord-297652-ut6e1ysz 35 4 of of IN cord-297652-ut6e1ysz 35 5 each each DT cord-297652-ut6e1ysz 35 6 of of IN cord-297652-ut6e1ysz 35 7 the the DT cord-297652-ut6e1ysz 35 8 four four CD cord-297652-ut6e1ysz 35 9 actual actual JJ cord-297652-ut6e1ysz 35 10 treatments treatment NNS cord-297652-ut6e1ysz 35 11 are be VBP cord-297652-ut6e1ysz 35 12 given give VBN cord-297652-ut6e1ysz 35 13 in in IN cord-297652-ut6e1ysz 35 14 Table Table NNP cord-297652-ut6e1ysz 35 15 2 2 CD cord-297652-ut6e1ysz 35 16 . . . cord-297652-ut6e1ysz 36 1 Remdesivir Remdesivir NNP cord-297652-ut6e1ysz 36 2 is be VBZ cord-297652-ut6e1ysz 36 3 an an DT cord-297652-ut6e1ysz 36 4 investigational investigational JJ cord-297652-ut6e1ysz 36 5 drug drug NN cord-297652-ut6e1ysz 36 6 developed develop VBN cord-297652-ut6e1ysz 36 7 by by IN cord-297652-ut6e1ysz 36 8 Gilead Gilead NNP cord-297652-ut6e1ysz 36 9 Sciences Sciences NNPS cord-297652-ut6e1ysz 36 10 . . . cord-297652-ut6e1ysz 37 1 Before before IN cord-297652-ut6e1ysz 37 2 the the DT cord-297652-ut6e1ysz 37 3 outbreak outbreak NN cord-297652-ut6e1ysz 37 4 of of IN cord-297652-ut6e1ysz 37 5 SARS SARS NNP cord-297652-ut6e1ysz 37 6 - - HYPH cord-297652-ut6e1ysz 37 7 CoV-2 CoV-2 NNP cord-297652-ut6e1ysz 37 8 , , , cord-297652-ut6e1ysz 37 9 it -PRON- PRP cord-297652-ut6e1ysz 37 10 has have VBZ cord-297652-ut6e1ysz 37 11 been be VBN cord-297652-ut6e1ysz 37 12 the the DT cord-297652-ut6e1ysz 37 13 subject subject NN cord-297652-ut6e1ysz 37 14 of of IN cord-297652-ut6e1ysz 37 15 only only RB cord-297652-ut6e1ysz 37 16 one one CD cord-297652-ut6e1ysz 37 17 clinical clinical JJ cord-297652-ut6e1ysz 37 18 trial trial NN cord-297652-ut6e1ysz 37 19 , , , cord-297652-ut6e1ysz 37 20 following follow VBG cord-297652-ut6e1ysz 37 21 the the DT cord-297652-ut6e1ysz 37 22 U.S. U.S. NNP cord-297652-ut6e1ysz 37 23 National National NNP cord-297652-ut6e1ysz 37 24 Library Library NNP cord-297652-ut6e1ysz 37 25 of of IN cord-297652-ut6e1ysz 37 26 Medicine Medicine NNP cord-297652-ut6e1ysz 37 27 of of IN cord-297652-ut6e1ysz 37 28 the the DT cord-297652-ut6e1ysz 37 29 National National NNP cord-297652-ut6e1ysz 37 30 Institutes Institutes NNPS cord-297652-ut6e1ysz 37 31 of of IN cord-297652-ut6e1ysz 37 32 Health Health NNP cord-297652-ut6e1ysz 37 33 [ [ -LRB- cord-297652-ut6e1ysz 37 34 4 4 CD cord-297652-ut6e1ysz 37 35 ] ] -RRB- cord-297652-ut6e1ysz 37 36 . . . cord-297652-ut6e1ysz 38 1 That that DT cord-297652-ut6e1ysz 38 2 study study NN cord-297652-ut6e1ysz 38 3 ( ( -LRB- cord-297652-ut6e1ysz 38 4 NCT03719586 NCT03719586 NNP cord-297652-ut6e1ysz 38 5 ) ) -RRB- cord-297652-ut6e1ysz 38 6 was be VBD cord-297652-ut6e1ysz 38 7 entitled entitle VBN cord-297652-ut6e1ysz 38 8 " " `` cord-297652-ut6e1ysz 38 9 Investigational Investigational NNP cord-297652-ut6e1ysz 38 10 Therapeutics Therapeutics NNPS cord-297652-ut6e1ysz 38 11 for for IN cord-297652-ut6e1ysz 38 12 the the DT cord-297652-ut6e1ysz 38 13 Treatment Treatment NNP cord-297652-ut6e1ysz 38 14 of of IN cord-297652-ut6e1ysz 38 15 People People NNPS cord-297652-ut6e1ysz 38 16 with with IN cord-297652-ut6e1ysz 38 17 Ebola Ebola NNP cord-297652-ut6e1ysz 38 18 Virus Virus NNP cord-297652-ut6e1ysz 38 19 Disease Disease NNP cord-297652-ut6e1ysz 38 20 " " '' cord-297652-ut6e1ysz 38 21 and and CC cord-297652-ut6e1ysz 38 22 started start VBD cord-297652-ut6e1ysz 38 23 on on IN cord-297652-ut6e1ysz 38 24 November November NNP cord-297652-ut6e1ysz 38 25 21 21 CD cord-297652-ut6e1ysz 38 26 , , , cord-297652-ut6e1ysz 38 27 2018 2018 CD cord-297652-ut6e1ysz 38 28 . . . cord-297652-ut6e1ysz 39 1 Three three CD cord-297652-ut6e1ysz 39 2 monoclonal monoclonal JJ cord-297652-ut6e1ysz 39 3 antibodies antibody NNS cord-297652-ut6e1ysz 39 4 ( ( -LRB- cord-297652-ut6e1ysz 39 5 ZMapp ZMapp NNP cord-297652-ut6e1ysz 39 6 for for IN cord-297652-ut6e1ysz 39 7 the the DT cord-297652-ut6e1ysz 39 8 control control NN cord-297652-ut6e1ysz 39 9 group group NN cord-297652-ut6e1ysz 39 10 , , , cord-297652-ut6e1ysz 39 11 REGN REGN NNP cord-297652-ut6e1ysz 39 12 - - HYPH cord-297652-ut6e1ysz 39 13 EB3 EB3 NNP cord-297652-ut6e1ysz 39 14 , , , cord-297652-ut6e1ysz 39 15 Mab114 Mab114 NNP cord-297652-ut6e1ysz 39 16 ) ) -RRB- cord-297652-ut6e1ysz 39 17 and and CC cord-297652-ut6e1ysz 39 18 remdesivir remdesivir NNP cord-297652-ut6e1ysz 39 19 were be VBD cord-297652-ut6e1ysz 39 20 separately separately RB cord-297652-ut6e1ysz 39 21 administered administer VBN cord-297652-ut6e1ysz 39 22 to to IN cord-297652-ut6e1ysz 39 23 a a DT cord-297652-ut6e1ysz 39 24 total total NN cord-297652-ut6e1ysz 39 25 of of IN cord-297652-ut6e1ysz 39 26 673 673 CD cord-297652-ut6e1ysz 39 27 participants participant NNS cord-297652-ut6e1ysz 39 28 . . . cord-297652-ut6e1ysz 40 1 An an DT cord-297652-ut6e1ysz 40 2 initial initial JJ cord-297652-ut6e1ysz 40 3 dose dose NN cord-297652-ut6e1ysz 40 4 of of IN cord-297652-ut6e1ysz 40 5 200 200 CD cord-297652-ut6e1ysz 40 6 mg mg NN cord-297652-ut6e1ysz 40 7 of of IN cord-297652-ut6e1ysz 40 8 remdesivir remdesivir NNP cord-297652-ut6e1ysz 40 9 was be VBD cord-297652-ut6e1ysz 40 10 administered administer VBN cord-297652-ut6e1ysz 40 11 on on IN cord-297652-ut6e1ysz 40 12 day day NN cord-297652-ut6e1ysz 40 13 1 1 CD cord-297652-ut6e1ysz 40 14 , , , cord-297652-ut6e1ysz 40 15 followed follow VBN cord-297652-ut6e1ysz 40 16 by by IN cord-297652-ut6e1ysz 40 17 a a DT cord-297652-ut6e1ysz 40 18 daily daily JJ cord-297652-ut6e1ysz 40 19 maintenance maintenance NN cord-297652-ut6e1ysz 40 20 dose dose NN cord-297652-ut6e1ysz 40 21 of of IN cord-297652-ut6e1ysz 40 22 100 100 CD cord-297652-ut6e1ysz 40 23 mg mg NN cord-297652-ut6e1ysz 40 24 for for IN cord-297652-ut6e1ysz 40 25 9 9 CD cord-297652-ut6e1ysz 40 26 - - SYM cord-297652-ut6e1ysz 40 27 13 13 CD cord-297652-ut6e1ysz 40 28 days day NNS cord-297652-ut6e1ysz 40 29 . . . cord-297652-ut6e1ysz 41 1 Results result NNS cord-297652-ut6e1ysz 41 2 were be VBD cord-297652-ut6e1ysz 41 3 disappointing disappointing JJ cord-297652-ut6e1ysz 41 4 . . . cord-297652-ut6e1ysz 42 1 After after IN cord-297652-ut6e1ysz 42 2 28 28 CD cord-297652-ut6e1ysz 42 3 days day NNS cord-297652-ut6e1ysz 42 4 , , , cord-297652-ut6e1ysz 42 5 the the DT cord-297652-ut6e1ysz 42 6 highest high JJS cord-297652-ut6e1ysz 42 7 number number NN cord-297652-ut6e1ysz 42 8 of of IN cord-297652-ut6e1ysz 42 9 deaths death NNS cord-297652-ut6e1ysz 42 10 ( ( -LRB- cord-297652-ut6e1ysz 42 11 53.1 53.1 CD cord-297652-ut6e1ysz 42 12 % % NN cord-297652-ut6e1ysz 42 13 ) ) -RRB- cord-297652-ut6e1ysz 42 14 was be VBD cord-297652-ut6e1ysz 42 15 _SP cord-297652-ut6e1ysz 43 1 It -PRON- PRP cord-297652-ut6e1ysz 43 2 has have VBZ cord-297652-ut6e1ysz 43 3 been be VBN cord-297652-ut6e1ysz 43 4 announced announce VBN cord-297652-ut6e1ysz 43 5 that that IN cord-297652-ut6e1ysz 43 6 the the DT cord-297652-ut6e1ysz 43 7 Discovery Discovery NNP cord-297652-ut6e1ysz 43 8 project project NN cord-297652-ut6e1ysz 43 9 is be VBZ cord-297652-ut6e1ysz 43 10 an an DT cord-297652-ut6e1ysz 43 11 adaptive adaptive JJ cord-297652-ut6e1ysz 43 12 study study NN cord-297652-ut6e1ysz 43 13 . . . cord-297652-ut6e1ysz 44 1 That that DT cord-297652-ut6e1ysz 44 2 means mean VBZ cord-297652-ut6e1ysz 44 3 that that IN cord-297652-ut6e1ysz 44 4 some some DT cord-297652-ut6e1ysz 44 5 treatments treatment NNS cord-297652-ut6e1ysz 44 6 can can MD cord-297652-ut6e1ysz 44 7 be be VB cord-297652-ut6e1ysz 44 8 abandoned abandon VBN cord-297652-ut6e1ysz 44 9 during during IN cord-297652-ut6e1ysz 44 10 the the DT cord-297652-ut6e1ysz 44 11 study study NN cord-297652-ut6e1ysz 44 12 if if IN cord-297652-ut6e1ysz 44 13 results result NNS cord-297652-ut6e1ysz 44 14 are be VBP cord-297652-ut6e1ysz 44 15 not not RB cord-297652-ut6e1ysz 44 16 encouraging encouraging JJ cord-297652-ut6e1ysz 44 17 , , , cord-297652-ut6e1ysz 44 18 whereas whereas IN cord-297652-ut6e1ysz 44 19 new new JJ cord-297652-ut6e1ysz 44 20 treatments treatment NNS cord-297652-ut6e1ysz 44 21 could could MD cord-297652-ut6e1ysz 44 22 be be VB cord-297652-ut6e1ysz 44 23 added add VBN cord-297652-ut6e1ysz 44 24 . . . cord-297652-ut6e1ysz 45 1 Some some DT cord-297652-ut6e1ysz 45 2 noticeable noticeable JJ cord-297652-ut6e1ysz 45 3 characteristics characteristic NNS cord-297652-ut6e1ysz 45 4 of of IN cord-297652-ut6e1ysz 45 5 each each DT cord-297652-ut6e1ysz 45 6 of of IN cord-297652-ut6e1ysz 45 7 the the DT cord-297652-ut6e1ysz 45 8 four four CD cord-297652-ut6e1ysz 45 9 actual actual JJ cord-297652-ut6e1ysz 45 10 treatments treatment NNS cord-297652-ut6e1ysz 45 11 are be VBP cord-297652-ut6e1ysz 45 12 given give VBN cord-297652-ut6e1ysz 45 13 in in IN cord-297652-ut6e1ysz 45 14 Table Table NNP cord-297652-ut6e1ysz 45 15 2 2 CD cord-297652-ut6e1ysz 45 16 . . . cord-297652-ut6e1ysz 46 1 Remdesivir Remdesivir NNP cord-297652-ut6e1ysz 46 2 is be VBZ cord-297652-ut6e1ysz 46 3 an an DT cord-297652-ut6e1ysz 46 4 investigational investigational JJ cord-297652-ut6e1ysz 46 5 drug drug NN cord-297652-ut6e1ysz 46 6 developed develop VBN cord-297652-ut6e1ysz 46 7 by by IN cord-297652-ut6e1ysz 46 8 Gilead Gilead NNP cord-297652-ut6e1ysz 46 9 Sciences Sciences NNPS cord-297652-ut6e1ysz 46 10 . . . cord-297652-ut6e1ysz 47 1 Before before IN cord-297652-ut6e1ysz 47 2 the the DT cord-297652-ut6e1ysz 47 3 outbreak outbreak NN cord-297652-ut6e1ysz 47 4 of of IN cord-297652-ut6e1ysz 47 5 SARS SARS NNP cord-297652-ut6e1ysz 47 6 - - HYPH cord-297652-ut6e1ysz 47 7 CoV-2 CoV-2 NNP cord-297652-ut6e1ysz 47 8 , , , cord-297652-ut6e1ysz 47 9 it -PRON- PRP cord-297652-ut6e1ysz 47 10 has have VBZ cord-297652-ut6e1ysz 47 11 been be VBN cord-297652-ut6e1ysz 47 12 the the DT cord-297652-ut6e1ysz 47 13 subject subject NN cord-297652-ut6e1ysz 47 14 of of IN cord-297652-ut6e1ysz 47 15 only only RB cord-297652-ut6e1ysz 47 16 one one CD cord-297652-ut6e1ysz 47 17 clinical clinical JJ cord-297652-ut6e1ysz 47 18 trial trial NN cord-297652-ut6e1ysz 47 19 , , , cord-297652-ut6e1ysz 47 20 following follow VBG cord-297652-ut6e1ysz 47 21 the the DT cord-297652-ut6e1ysz 47 22 U.S. U.S. NNP cord-297652-ut6e1ysz 47 23 National National NNP cord-297652-ut6e1ysz 47 24 Library Library NNP cord-297652-ut6e1ysz 47 25 of of IN cord-297652-ut6e1ysz 47 26 Medicine Medicine NNP cord-297652-ut6e1ysz 47 27 of of IN cord-297652-ut6e1ysz 47 28 the the DT cord-297652-ut6e1ysz 47 29 National National NNP cord-297652-ut6e1ysz 47 30 Institutes Institutes NNPS cord-297652-ut6e1ysz 47 31 of of IN cord-297652-ut6e1ysz 47 32 Health Health NNP cord-297652-ut6e1ysz 47 33 [ [ -LRB- cord-297652-ut6e1ysz 47 34 4 4 CD cord-297652-ut6e1ysz 47 35 ] ] -RRB- cord-297652-ut6e1ysz 47 36 . . . cord-297652-ut6e1ysz 48 1 That that DT cord-297652-ut6e1ysz 48 2 study study NN cord-297652-ut6e1ysz 48 3 ( ( -LRB- cord-297652-ut6e1ysz 48 4 NCT03719586 NCT03719586 NNP cord-297652-ut6e1ysz 48 5 ) ) -RRB- cord-297652-ut6e1ysz 48 6 was be VBD cord-297652-ut6e1ysz 48 7 entitled entitle VBN cord-297652-ut6e1ysz 48 8 " " `` cord-297652-ut6e1ysz 48 9 Investigational Investigational NNP cord-297652-ut6e1ysz 48 10 Therapeutics Therapeutics NNPS cord-297652-ut6e1ysz 48 11 for for IN cord-297652-ut6e1ysz 48 12 the the DT cord-297652-ut6e1ysz 48 13 Treatment Treatment NNP cord-297652-ut6e1ysz 48 14 of of IN cord-297652-ut6e1ysz 48 15 People People NNPS cord-297652-ut6e1ysz 48 16 with with IN cord-297652-ut6e1ysz 48 17 Ebola Ebola NNP cord-297652-ut6e1ysz 48 18 Virus Virus NNP cord-297652-ut6e1ysz 48 19 Disease Disease NNP cord-297652-ut6e1ysz 48 20 " " '' cord-297652-ut6e1ysz 48 21 and and CC cord-297652-ut6e1ysz 48 22 started start VBD cord-297652-ut6e1ysz 48 23 on on IN cord-297652-ut6e1ysz 48 24 November November NNP cord-297652-ut6e1ysz 48 25 21 21 CD cord-297652-ut6e1ysz 48 26 , , , cord-297652-ut6e1ysz 48 27 2018 2018 CD cord-297652-ut6e1ysz 48 28 . . . cord-297652-ut6e1ysz 49 1 Three three CD cord-297652-ut6e1ysz 49 2 monoclonal monoclonal JJ cord-297652-ut6e1ysz 49 3 antibodies antibody NNS cord-297652-ut6e1ysz 49 4 ( ( -LRB- cord-297652-ut6e1ysz 49 5 ZMapp ZMapp NNP cord-297652-ut6e1ysz 49 6 for for IN cord-297652-ut6e1ysz 49 7 the the DT cord-297652-ut6e1ysz 49 8 control control NN cord-297652-ut6e1ysz 49 9 group group NN cord-297652-ut6e1ysz 49 10 , , , cord-297652-ut6e1ysz 49 11 REGN REGN NNP cord-297652-ut6e1ysz 49 12 - - HYPH cord-297652-ut6e1ysz 49 13 EB3 EB3 NNP cord-297652-ut6e1ysz 49 14 , , , cord-297652-ut6e1ysz 49 15 Mab114 Mab114 NNP cord-297652-ut6e1ysz 49 16 ) ) -RRB- cord-297652-ut6e1ysz 49 17 and and CC cord-297652-ut6e1ysz 49 18 remdesivir remdesivir NNP cord-297652-ut6e1ysz 49 19 were be VBD cord-297652-ut6e1ysz 49 20 separately separately RB cord-297652-ut6e1ysz 49 21 administered administer VBN cord-297652-ut6e1ysz 49 22 to to IN cord-297652-ut6e1ysz 49 23 a a DT cord-297652-ut6e1ysz 49 24 total total NN cord-297652-ut6e1ysz 49 25 of of IN cord-297652-ut6e1ysz 49 26 673 673 CD cord-297652-ut6e1ysz 49 27 participants participant NNS cord-297652-ut6e1ysz 49 28 . . . cord-297652-ut6e1ysz 50 1 An an DT cord-297652-ut6e1ysz 50 2 initial initial JJ cord-297652-ut6e1ysz 50 3 dose dose NN cord-297652-ut6e1ysz 50 4 of of IN cord-297652-ut6e1ysz 50 5 200 200 CD cord-297652-ut6e1ysz 50 6 mg mg NN cord-297652-ut6e1ysz 50 7 of of IN cord-297652-ut6e1ysz 50 8 remdesivir remdesivir NNP cord-297652-ut6e1ysz 50 9 was be VBD cord-297652-ut6e1ysz 50 10 administered administer VBN cord-297652-ut6e1ysz 50 11 on on IN cord-297652-ut6e1ysz 50 12 day day NN cord-297652-ut6e1ysz 50 13 1 1 CD cord-297652-ut6e1ysz 50 14 , , , cord-297652-ut6e1ysz 50 15 followed follow VBN cord-297652-ut6e1ysz 50 16 by by IN cord-297652-ut6e1ysz 50 17 a a DT cord-297652-ut6e1ysz 50 18 daily daily JJ cord-297652-ut6e1ysz 50 19 maintenance maintenance NN cord-297652-ut6e1ysz 50 20 dose dose NN cord-297652-ut6e1ysz 50 21 of of IN cord-297652-ut6e1ysz 50 22 100 100 CD cord-297652-ut6e1ysz 50 23 mg mg NN cord-297652-ut6e1ysz 50 24 for for IN cord-297652-ut6e1ysz 50 25 9 9 CD cord-297652-ut6e1ysz 50 26 - - SYM cord-297652-ut6e1ysz 50 27 13 13 CD cord-297652-ut6e1ysz 50 28 days day NNS cord-297652-ut6e1ysz 50 29 . . . cord-297652-ut6e1ysz 51 1 Results result NNS cord-297652-ut6e1ysz 51 2 were be VBD cord-297652-ut6e1ysz 51 3 disappointing disappointing JJ cord-297652-ut6e1ysz 51 4 . . . cord-297652-ut6e1ysz 52 1 After after IN cord-297652-ut6e1ysz 52 2 28 28 CD cord-297652-ut6e1ysz 52 3 days day NNS cord-297652-ut6e1ysz 52 4 , , , cord-297652-ut6e1ysz 52 5 the the DT cord-297652-ut6e1ysz 52 6 highest high JJS cord-297652-ut6e1ysz 52 7 number number NN cord-297652-ut6e1ysz 52 8 of of IN cord-297652-ut6e1ysz 52 9 deaths death NNS cord-297652-ut6e1ysz 52 10 ( ( -LRB- cord-297652-ut6e1ysz 52 11 53.1 53.1 CD cord-297652-ut6e1ysz 52 12 % % NN cord-297652-ut6e1ysz 52 13 ) ) -RRB- cord-297652-ut6e1ysz 52 14 was be VBD cord-297652-ut6e1ysz 52 15 observed observe VBN cord-297652-ut6e1ysz 52 16 in in IN cord-297652-ut6e1ysz 52 17 the the DT cord-297652-ut6e1ysz 52 18 group group NN cord-297652-ut6e1ysz 52 19 treated treat VBN cord-297652-ut6e1ysz 52 20 with with IN cord-297652-ut6e1ysz 52 21 remdesivir remdesivir NNP cord-297652-ut6e1ysz 52 22 , , , cord-297652-ut6e1ysz 52 23 a a DT cord-297652-ut6e1ysz 52 24 bit bit NN cord-297652-ut6e1ysz 52 25 more more JJR cord-297652-ut6e1ysz 52 26 than than IN cord-297652-ut6e1ysz 52 27 in in IN cord-297652-ut6e1ysz 52 28 the the DT cord-297652-ut6e1ysz 52 29 control control NN cord-297652-ut6e1ysz 52 30 group group NN cord-297652-ut6e1ysz 52 31 ( ( -LRB- cord-297652-ut6e1ysz 52 32 49.7 49.7 CD cord-297652-ut6e1ysz 52 33 % % NN cord-297652-ut6e1ysz 52 34 ) ) -RRB- cord-297652-ut6e1ysz 52 35 . . . cord-297652-ut6e1ysz 53 1 More more RBR cord-297652-ut6e1ysz 53 2 encouraging encouraging JJ cord-297652-ut6e1ysz 53 3 results result NNS cord-297652-ut6e1ysz 53 4 were be VBD cord-297652-ut6e1ysz 53 5 obtained obtain VBN cord-297652-ut6e1ysz 53 6 in in IN cord-297652-ut6e1ysz 53 7 the the DT cord-297652-ut6e1ysz 53 8 two two CD cord-297652-ut6e1ysz 53 9 other other JJ cord-297652-ut6e1ysz 53 10 groups group NNS cord-297652-ut6e1ysz 53 11 ( ( -LRB- cord-297652-ut6e1ysz 53 12 REGN REGN NNP cord-297652-ut6e1ysz 53 13 - - HYPH cord-297652-ut6e1ysz 53 14 EB3 EB3 NNP cord-297652-ut6e1ysz 53 15 : : : cord-297652-ut6e1ysz 53 16 33.5 33.5 CD cord-297652-ut6e1ysz 53 17 % % NN cord-297652-ut6e1ysz 53 18 ; ; . cord-297652-ut6e1ysz 54 1 Mab114 Mab114 NNS cord-297652-ut6e1ysz 54 2 : : : cord-297652-ut6e1ysz 54 3 35.1 35.1 CD cord-297652-ut6e1ysz 54 4 % % NN cord-297652-ut6e1ysz 54 5 ) ) -RRB- cord-297652-ut6e1ysz 54 6 [ [ -LRB- cord-297652-ut6e1ysz 54 7 7 7 CD cord-297652-ut6e1ysz 54 8 ] ] -RRB- cord-297652-ut6e1ysz 54 9 . . . cord-297652-ut6e1ysz 55 1 In in IN cord-297652-ut6e1ysz 55 2 contrast contrast NN cord-297652-ut6e1ysz 55 3 , , , cord-297652-ut6e1ysz 55 4 in in IN cord-297652-ut6e1ysz 55 5 the the DT cord-297652-ut6e1ysz 55 6 cases case NNS cord-297652-ut6e1ysz 55 7 of of IN cord-297652-ut6e1ysz 55 8 SARS SARS NNP cord-297652-ut6e1ysz 55 9 - - HYPH cord-297652-ut6e1ysz 55 10 CoV CoV NNP cord-297652-ut6e1ysz 55 11 and and CC cord-297652-ut6e1ysz 55 12 MERS MERS NNP cord-297652-ut6e1ysz 55 13 - - HYPH cord-297652-ut6e1ysz 55 14 CoV CoV NNP cord-297652-ut6e1ysz 55 15 , , , cord-297652-ut6e1ysz 55 16 remdesivir remdesivir NNP cord-297652-ut6e1ysz 55 17 exhibited exhibit VBD cord-297652-ut6e1ysz 55 18 an an DT cord-297652-ut6e1ysz 55 19 excellent excellent JJ cord-297652-ut6e1ysz 55 20 activity activity NN cord-297652-ut6e1ysz 55 21 , , , cord-297652-ut6e1ysz 55 22 in in IN cord-297652-ut6e1ysz 55 23 vitro vitro FW cord-297652-ut6e1ysz 55 24 , , , cord-297652-ut6e1ysz 55 25 in in IN cord-297652-ut6e1ysz 55 26 the the DT cord-297652-ut6e1ysz 55 27 submicromolar submicromolar NN cord-297652-ut6e1ysz 55 28 range range NN cord-297652-ut6e1ysz 55 29 with with IN cord-297652-ut6e1ysz 55 30 EC EC NNP cord-297652-ut6e1ysz 55 31 50 50 CD cord-297652-ut6e1ysz 55 32 values value NNS cord-297652-ut6e1ysz 55 33 of of IN cord-297652-ut6e1ysz 55 34 0.07 0.07 CD cord-297652-ut6e1ysz 55 35 µM µM NFP cord-297652-ut6e1ysz 55 36 for for IN cord-297652-ut6e1ysz 55 37 both both DT cord-297652-ut6e1ysz 55 38 coronaviruses coronaviruse NNS cord-297652-ut6e1ysz 55 39 [ [ -LRB- cord-297652-ut6e1ysz 55 40 8 8 CD cord-297652-ut6e1ysz 55 41 ] ] -RRB- cord-297652-ut6e1ysz 55 42 . . . cord-297652-ut6e1ysz 56 1 Results result NNS cord-297652-ut6e1ysz 56 2 were be VBD cord-297652-ut6e1ysz 56 3 confirmed confirm VBN cord-297652-ut6e1ysz 56 4 in in IN cord-297652-ut6e1ysz 56 5 vivo vivo NN cord-297652-ut6e1ysz 56 6 in in IN cord-297652-ut6e1ysz 56 7 the the DT cord-297652-ut6e1ysz 56 8 case case NN cord-297652-ut6e1ysz 56 9 of of IN cord-297652-ut6e1ysz 56 10 an an DT cord-297652-ut6e1ysz 56 11 infection infection NN cord-297652-ut6e1ysz 56 12 by by IN cord-297652-ut6e1ysz 56 13 MERS MERS NNP cord-297652-ut6e1ysz 56 14 - - HYPH cord-297652-ut6e1ysz 56 15 CoV CoV NNP cord-297652-ut6e1ysz 56 16 in in IN cord-297652-ut6e1ysz 56 17 mice mouse NNS cord-297652-ut6e1ysz 56 18 [ [ -LRB- cord-297652-ut6e1ysz 56 19 9 9 CD cord-297652-ut6e1ysz 56 20 ] ] -RRB- cord-297652-ut6e1ysz 56 21 and and CC cord-297652-ut6e1ysz 56 22 rhesus rhesus NN cord-297652-ut6e1ysz 56 23 macaque macaque NN cord-297652-ut6e1ysz 56 24 models model NNS cord-297652-ut6e1ysz 56 25 [ [ -LRB- cord-297652-ut6e1ysz 56 26 10 10 CD cord-297652-ut6e1ysz 56 27 ] ] -RRB- cord-297652-ut6e1ysz 56 28 . . . cord-297652-ut6e1ysz 57 1 However however RB cord-297652-ut6e1ysz 57 2 , , , cord-297652-ut6e1ysz 57 3 Pharmaceuticals Pharmaceuticals NNP cord-297652-ut6e1ysz 57 4 2020 2020 CD cord-297652-ut6e1ysz 57 5 , , , cord-297652-ut6e1ysz 57 6 13 13 CD cord-297652-ut6e1ysz 57 7 , , , cord-297652-ut6e1ysz 57 8 65 65 CD cord-297652-ut6e1ysz 57 9 4 4 CD cord-297652-ut6e1ysz 57 10 of of IN cord-297652-ut6e1ysz 57 11 8 8 CD cord-297652-ut6e1ysz 57 12 the the DT cord-297652-ut6e1ysz 57 13 conclusion conclusion NN cord-297652-ut6e1ysz 57 14 of of IN cord-297652-ut6e1ysz 57 15 Sheahan Sheahan NNP cord-297652-ut6e1ysz 57 16 [ [ -LRB- cord-297652-ut6e1ysz 57 17 9 9 CD cord-297652-ut6e1ysz 57 18 ] ] -RRB- cord-297652-ut6e1ysz 57 19 regarding regard VBG cord-297652-ut6e1ysz 57 20 SARS SARS NNP cord-297652-ut6e1ysz 57 21 - - HYPH cord-297652-ut6e1ysz 57 22 CoV CoV NNP cord-297652-ut6e1ysz 57 23 in in IN cord-297652-ut6e1ysz 57 24 a a DT cord-297652-ut6e1ysz 57 25 mouse mouse NN cord-297652-ut6e1ysz 57 26 model model NN cord-297652-ut6e1ysz 57 27 warned warn VBD cord-297652-ut6e1ysz 57 28 that that IN cord-297652-ut6e1ysz 57 29 " " `` cord-297652-ut6e1ysz 57 30 These these DT cord-297652-ut6e1ysz 57 31 data datum NNS cord-297652-ut6e1ysz 57 32 suggest suggest VBP cord-297652-ut6e1ysz 57 33 that that IN cord-297652-ut6e1ysz 57 34 reductions reduction NNS cord-297652-ut6e1ysz 57 35 in in IN cord-297652-ut6e1ysz 57 36 viral viral JJ cord-297652-ut6e1ysz 57 37 load load NN cord-297652-ut6e1ysz 57 38 after after IN cord-297652-ut6e1ysz 57 39 peak peak NN cord-297652-ut6e1ysz 57 40 lung lung NN cord-297652-ut6e1ysz 57 41 titers titer NNS cord-297652-ut6e1ysz 57 42 were be VBD cord-297652-ut6e1ysz 57 43 achieved achieve VBN cord-297652-ut6e1ysz 57 44 were be VBD cord-297652-ut6e1ysz 57 45 insufficient insufficient JJ cord-297652-ut6e1ysz 57 46 to to TO cord-297652-ut6e1ysz 57 47 improve improve VB cord-297652-ut6e1ysz 57 48 outcomes outcome NNS cord-297652-ut6e1ysz 57 49 after after IN cord-297652-ut6e1ysz 57 50 the the DT cord-297652-ut6e1ysz 57 51 immunopathological immunopathological JJ cord-297652-ut6e1ysz 57 52 phase phase NN cord-297652-ut6e1ysz 57 53 of of IN cord-297652-ut6e1ysz 57 54 disease disease NN cord-297652-ut6e1ysz 57 55 had have VBD cord-297652-ut6e1ysz 57 56 been be VBN cord-297652-ut6e1ysz 57 57 initiated initiate VBN cord-297652-ut6e1ysz 57 58 . . . cord-297652-ut6e1ysz 58 1 Thus thus RB cord-297652-ut6e1ysz 58 2 , , , cord-297652-ut6e1ysz 58 3 in in IN cord-297652-ut6e1ysz 58 4 the the DT cord-297652-ut6e1ysz 58 5 mouse mouse NN cord-297652-ut6e1ysz 58 6 , , , cord-297652-ut6e1ysz 58 7 if if IN cord-297652-ut6e1ysz 58 8 given give VBN cord-297652-ut6e1ysz 58 9 prior prior RB cord-297652-ut6e1ysz 58 10 to to IN cord-297652-ut6e1ysz 58 11 the the DT cord-297652-ut6e1ysz 58 12 peak peak NN cord-297652-ut6e1ysz 58 13 of of IN cord-297652-ut6e1ysz 58 14 SARS SARS NNP cord-297652-ut6e1ysz 58 15 - - HYPH cord-297652-ut6e1ysz 58 16 CoV CoV NNP cord-297652-ut6e1ysz 58 17 replication replication NN cord-297652-ut6e1ysz 58 18 and and CC cord-297652-ut6e1ysz 58 19 peak peak NN cord-297652-ut6e1ysz 58 20 damage damage NN cord-297652-ut6e1ysz 58 21 to to IN cord-297652-ut6e1ysz 58 22 the the DT cord-297652-ut6e1ysz 58 23 airway airway NN cord-297652-ut6e1ysz 58 24 epithelium epithelium NN cord-297652-ut6e1ysz 58 25 , , , cord-297652-ut6e1ysz 58 26 GS-5734 GS-5734 NNP cord-297652-ut6e1ysz 58 27 ( ( -LRB- cord-297652-ut6e1ysz 58 28 remdesivir remdesivir NNP cord-297652-ut6e1ysz 58 29 ) ) -RRB- cord-297652-ut6e1ysz 58 30 can can MD cord-297652-ut6e1ysz 58 31 improve improve VB cord-297652-ut6e1ysz 58 32 pulmonary pulmonary JJ cord-297652-ut6e1ysz 58 33 function function NN cord-297652-ut6e1ysz 58 34 , , , cord-297652-ut6e1ysz 58 35 reduce reduce VB cord-297652-ut6e1ysz 58 36 viral viral JJ cord-297652-ut6e1ysz 58 37 loads load NNS cord-297652-ut6e1ysz 58 38 and and CC cord-297652-ut6e1ysz 58 39 diminish diminish VB cord-297652-ut6e1ysz 58 40 disease disease NN cord-297652-ut6e1ysz 58 41 . . . cord-297652-ut6e1ysz 58 42 " " '' cord-297652-ut6e1ysz 59 1 An an DT cord-297652-ut6e1ysz 59 2 EC EC NNP cord-297652-ut6e1ysz 59 3 50 50 CD cord-297652-ut6e1ysz 59 4 value value NN cord-297652-ut6e1ysz 59 5 of of IN cord-297652-ut6e1ysz 59 6 1.76 1.76 CD cord-297652-ut6e1ysz 59 7 µM µm CD cord-297652-ut6e1ysz 59 8 for for IN cord-297652-ut6e1ysz 59 9 remdesivir remdesivir NNP cord-297652-ut6e1ysz 59 10 against against IN cord-297652-ut6e1ysz 59 11 SARS SARS NNP cord-297652-ut6e1ysz 59 12 - - HYPH cord-297652-ut6e1ysz 59 13 CoV-2 CoV-2 NNP cord-297652-ut6e1ysz 59 14 in in IN cord-297652-ut6e1ysz 59 15 Vero Vero NNP cord-297652-ut6e1ysz 59 16 E6 E6 NNP cord-297652-ut6e1ysz 59 17 cells cell NNS cord-297652-ut6e1ysz 59 18 has have VBZ cord-297652-ut6e1ysz 59 19 been be VBN cord-297652-ut6e1ysz 59 20 measured measure VBN cord-297652-ut6e1ysz 59 21 by by IN cord-297652-ut6e1ysz 59 22 Wang Wang NNP cord-297652-ut6e1ysz 59 23 et et NNP cord-297652-ut6e1ysz 59 24 al al NNP cord-297652-ut6e1ysz 59 25 . . . cord-297652-ut6e1ysz 60 1 [ [ -LRB- cord-297652-ut6e1ysz 60 2 11 11 CD cord-297652-ut6e1ysz 60 3 ] ] -RRB- cord-297652-ut6e1ysz 60 4 . . . cord-297652-ut6e1ysz 61 1 There there EX cord-297652-ut6e1ysz 61 2 is be VBZ cord-297652-ut6e1ysz 61 3 a a DT cord-297652-ut6e1ysz 61 4 study study NN cord-297652-ut6e1ysz 61 5 involving involve VBG cord-297652-ut6e1ysz 61 6 only only RB cord-297652-ut6e1ysz 61 7 one one CD cord-297652-ut6e1ysz 61 8 human human NN cord-297652-ut6e1ysz 61 9 : : : cord-297652-ut6e1ysz 61 10 the the DT cord-297652-ut6e1ysz 61 11 first first JJ cord-297652-ut6e1ysz 61 12 patient patient NN cord-297652-ut6e1ysz 61 13 suffering suffer VBG cord-297652-ut6e1ysz 61 14 from from IN cord-297652-ut6e1ysz 61 15 COVID-19 COVID-19 NNP cord-297652-ut6e1ysz 61 16 in in IN cord-297652-ut6e1ysz 61 17 the the DT cord-297652-ut6e1ysz 61 18 United United NNP cord-297652-ut6e1ysz 61 19 States States NNP cord-297652-ut6e1ysz 61 20 [ [ -LRB- cord-297652-ut6e1ysz 61 21 12 12 CD cord-297652-ut6e1ysz 61 22 ] ] -RRB- cord-297652-ut6e1ysz 61 23 . . . cord-297652-ut6e1ysz 62 1 He -PRON- PRP cord-297652-ut6e1ysz 62 2 was be VBD cord-297652-ut6e1ysz 62 3 hospitalized hospitalize VBN cord-297652-ut6e1ysz 62 4 on on IN cord-297652-ut6e1ysz 62 5 January January NNP cord-297652-ut6e1ysz 62 6 19 19 CD cord-297652-ut6e1ysz 62 7 in in IN cord-297652-ut6e1ysz 62 8 the the DT cord-297652-ut6e1ysz 62 9 State State NNP cord-297652-ut6e1ysz 62 10 of of IN cord-297652-ut6e1ysz 62 11 Washington Washington NNP cord-297652-ut6e1ysz 62 12 . . . cord-297652-ut6e1ysz 63 1 For for IN cord-297652-ut6e1ysz 63 2 the the DT cord-297652-ut6e1ysz 63 3 first first JJ cord-297652-ut6e1ysz 63 4 6 6 CD cord-297652-ut6e1ysz 63 5 days day NNS cord-297652-ut6e1ysz 63 6 of of IN cord-297652-ut6e1ysz 63 7 hospitalization hospitalization NN cord-297652-ut6e1ysz 63 8 ( ( -LRB- cord-297652-ut6e1ysz 63 9 days day NNS cord-297652-ut6e1ysz 63 10 5 5 CD cord-297652-ut6e1ysz 63 11 - - SYM cord-297652-ut6e1ysz 63 12 10 10 CD cord-297652-ut6e1ysz 63 13 of of IN cord-297652-ut6e1ysz 63 14 the the DT cord-297652-ut6e1ysz 63 15 illness illness NN cord-297652-ut6e1ysz 63 16 ) ) -RRB- cord-297652-ut6e1ysz 63 17 , , , cord-297652-ut6e1ysz 63 18 he -PRON- PRP cord-297652-ut6e1ysz 63 19 received receive VBD cord-297652-ut6e1ysz 63 20 650 650 CD cord-297652-ut6e1ysz 63 21 mg mg NN cord-297652-ut6e1ysz 63 22 of of IN cord-297652-ut6e1ysz 63 23 acetaminophen acetaminophen NN cord-297652-ut6e1ysz 63 24 every every DT cord-297652-ut6e1ysz 63 25 4 4 CD cord-297652-ut6e1ysz 63 26 h h NN cord-297652-ut6e1ysz 63 27 , , , cord-297652-ut6e1ysz 63 28 600 600 CD cord-297652-ut6e1ysz 63 29 mg mg NN cord-297652-ut6e1ysz 63 30 of of IN cord-297652-ut6e1ysz 63 31 ibuprofen ibuprofen NNP cord-297652-ut6e1ysz 63 32 every every DT cord-297652-ut6e1ysz 63 33 6 6 CD cord-297652-ut6e1ysz 63 34 h h NN cord-297652-ut6e1ysz 63 35 , , , cord-297652-ut6e1ysz 63 36 600 600 CD cord-297652-ut6e1ysz 63 37 mg mg NN cord-297652-ut6e1ysz 63 38 of of IN cord-297652-ut6e1ysz 63 39 guaifenesin guaifenesin NNP cord-297652-ut6e1ysz 63 40 and and CC cord-297652-ut6e1ysz 63 41 6 6 CD cord-297652-ut6e1ysz 63 42 liters liter NNS cord-297652-ut6e1ysz 63 43 of of IN cord-297652-ut6e1ysz 63 44 normal normal JJ cord-297652-ut6e1ysz 63 45 saline saline NN cord-297652-ut6e1ysz 63 46 . . . cord-297652-ut6e1ysz 64 1 On on IN cord-297652-ut6e1ysz 64 2 day day NN cord-297652-ut6e1ysz 64 3 6 6 CD cord-297652-ut6e1ysz 64 4 of of IN cord-297652-ut6e1ysz 64 5 hospitalization hospitalization NN cord-297652-ut6e1ysz 64 6 , , , cord-297652-ut6e1ysz 64 7 he -PRON- PRP cord-297652-ut6e1ysz 64 8 was be VBD cord-297652-ut6e1ysz 64 9 treated treat VBN cord-297652-ut6e1ysz 64 10 with with IN cord-297652-ut6e1ysz 64 11 vancomycin vancomycin NN cord-297652-ut6e1ysz 64 12 ( ( -LRB- cord-297652-ut6e1ysz 64 13 1750 1750 CD cord-297652-ut6e1ysz 64 14 mg mg NN cord-297652-ut6e1ysz 64 15 then then RB cord-297652-ut6e1ysz 64 16 1 1 CD cord-297652-ut6e1ysz 64 17 g g NN cord-297652-ut6e1ysz 64 18 every every DT cord-297652-ut6e1ysz 64 19 8 8 CD cord-297652-ut6e1ysz 64 20 h h NN cord-297652-ut6e1ysz 64 21 ) ) -RRB- cord-297652-ut6e1ysz 64 22 and and CC cord-297652-ut6e1ysz 64 23 cefepime cefepime NNP cord-297652-ut6e1ysz 64 24 ( ( -LRB- cord-297652-ut6e1ysz 64 25 every every DT cord-297652-ut6e1ysz 64 26 8 8 CD cord-297652-ut6e1ysz 64 27 h h NN cord-297652-ut6e1ysz 64 28 ) ) -RRB- cord-297652-ut6e1ysz 64 29 . . . cord-297652-ut6e1ysz 65 1 The the DT cord-297652-ut6e1ysz 65 2 next next JJ cord-297652-ut6e1ysz 65 3 day day NN cord-297652-ut6e1ysz 65 4 , , , cord-297652-ut6e1ysz 65 5 remdesivir remdesivir NNP cord-297652-ut6e1ysz 65 6 was be VBD cord-297652-ut6e1ysz 65 7 administered administer VBN cord-297652-ut6e1ysz 65 8 for for IN cord-297652-ut6e1ysz 65 9 compassionate compassionate JJ cord-297652-ut6e1ysz 65 10 use use NN cord-297652-ut6e1ysz 65 11 , , , cord-297652-ut6e1ysz 65 12 whereas whereas IN cord-297652-ut6e1ysz 65 13 the the DT cord-297652-ut6e1ysz 65 14 antibiotics antibiotic NNS cord-297652-ut6e1ysz 65 15 were be VBD cord-297652-ut6e1ysz 65 16 discontinued discontinue VBN cord-297652-ut6e1ysz 65 17 . . . cord-297652-ut6e1ysz 66 1 The the DT cord-297652-ut6e1ysz 66 2 authors author NNS cord-297652-ut6e1ysz 66 3 concluded conclude VBD cord-297652-ut6e1ysz 66 4 their -PRON- PRP$ cord-297652-ut6e1ysz 66 5 article article NN cord-297652-ut6e1ysz 66 6 by by IN cord-297652-ut6e1ysz 66 7 writing write VBG cord-297652-ut6e1ysz 66 8 [ [ -LRB- cord-297652-ut6e1ysz 66 9 12 12 CD cord-297652-ut6e1ysz 66 10 ] ] -RRB- cord-297652-ut6e1ysz 66 11 : : : cord-297652-ut6e1ysz 66 12 " " `` cord-297652-ut6e1ysz 66 13 On on IN cord-297652-ut6e1ysz 66 14 hospital hospital NN cord-297652-ut6e1ysz 66 15 day day NN cord-297652-ut6e1ysz 66 16 8 8 CD cord-297652-ut6e1ysz 66 17 ( ( -LRB- cord-297652-ut6e1ysz 66 18 illness illness NN cord-297652-ut6e1ysz 66 19 day day NN cord-297652-ut6e1ysz 66 20 12 12 CD cord-297652-ut6e1ysz 66 21 ) ) -RRB- cord-297652-ut6e1ysz 66 22 , , , cord-297652-ut6e1ysz 66 23 the the DT cord-297652-ut6e1ysz 66 24 patient patient NN cord-297652-ut6e1ysz 66 25 's 's POS cord-297652-ut6e1ysz 66 26 clinical clinical JJ cord-297652-ut6e1ysz 66 27 condition condition NN cord-297652-ut6e1ysz 66 28 improved improve VBN cord-297652-ut6e1ysz 66 29 . . . cord-297652-ut6e1ysz 67 1 Supplemental supplemental JJ cord-297652-ut6e1ysz 67 2 oxygen oxygen NN cord-297652-ut6e1ysz 67 3 was be VBD cord-297652-ut6e1ysz 67 4 discontinued discontinue VBN cord-297652-ut6e1ysz 67 5 , , , cord-297652-ut6e1ysz 67 6 and and CC cord-297652-ut6e1ysz 67 7 his -PRON- PRP$ cord-297652-ut6e1ysz 67 8 oxygen oxygen NN cord-297652-ut6e1ysz 67 9 saturation saturation NN cord-297652-ut6e1ysz 67 10 values value NNS cord-297652-ut6e1ysz 67 11 improved improve VBD cord-297652-ut6e1ysz 67 12 to to IN cord-297652-ut6e1ysz 67 13 94 94 CD cord-297652-ut6e1ysz 67 14 % % NN cord-297652-ut6e1ysz 67 15 to to TO cord-297652-ut6e1ysz 67 16 96 96 CD cord-297652-ut6e1ysz 67 17 % % NN cord-297652-ut6e1ysz 67 18 while while IN cord-297652-ut6e1ysz 67 19 he -PRON- PRP cord-297652-ut6e1ysz 67 20 was be VBD cord-297652-ut6e1ysz 67 21 breathing breathe VBG cord-297652-ut6e1ysz 67 22 ambient ambient JJ cord-297652-ut6e1ysz 67 23 air air NN cord-297652-ut6e1ysz 67 24 . . . cord-297652-ut6e1ysz 68 1 The the DT cord-297652-ut6e1ysz 68 2 previous previous JJ cord-297652-ut6e1ysz 68 3 bilateral bilateral JJ cord-297652-ut6e1ysz 68 4 lower low JJR cord-297652-ut6e1ysz 68 5 - - HYPH cord-297652-ut6e1ysz 68 6 lobe lobe NN cord-297652-ut6e1ysz 68 7 rales rale NNS cord-297652-ut6e1ysz 68 8 were be VBD cord-297652-ut6e1ysz 68 9 no no RB cord-297652-ut6e1ysz 68 10 longer long RBR cord-297652-ut6e1ysz 68 11 present present JJ cord-297652-ut6e1ysz 68 12 . . . cord-297652-ut6e1ysz 69 1 His -PRON- PRP$ cord-297652-ut6e1ysz 69 2 appetite appetite NN cord-297652-ut6e1ysz 69 3 improved improve VBD cord-297652-ut6e1ysz 69 4 , , , cord-297652-ut6e1ysz 69 5 and and CC cord-297652-ut6e1ysz 69 6 he -PRON- PRP cord-297652-ut6e1ysz 69 7 was be VBD cord-297652-ut6e1ysz 69 8 asymptomatic asymptomatic JJ cord-297652-ut6e1ysz 69 9 aside aside RB cord-297652-ut6e1ysz 69 10 from from IN cord-297652-ut6e1ysz 69 11 intermittent intermittent JJ cord-297652-ut6e1ysz 69 12 dry dry JJ cord-297652-ut6e1ysz 69 13 cough cough NN cord-297652-ut6e1ysz 69 14 and and CC cord-297652-ut6e1ysz 69 15 rhinorrhea rhinorrhea NN cord-297652-ut6e1ysz 69 16 . . . cord-297652-ut6e1ysz 70 1 As as IN cord-297652-ut6e1ysz 70 2 of of IN cord-297652-ut6e1ysz 70 3 January January NNP cord-297652-ut6e1ysz 70 4 30 30 CD cord-297652-ut6e1ysz 70 5 , , , cord-297652-ut6e1ysz 70 6 2020 2020 CD cord-297652-ut6e1ysz 70 7 , , , cord-297652-ut6e1ysz 70 8 the the DT cord-297652-ut6e1ysz 70 9 patient patient NN cord-297652-ut6e1ysz 70 10 remains remain VBZ cord-297652-ut6e1ysz 70 11 hospitalized hospitalize VBN cord-297652-ut6e1ysz 70 12 . . . cord-297652-ut6e1ysz 71 1 He -PRON- PRP cord-297652-ut6e1ysz 71 2 is be VBZ cord-297652-ut6e1ysz 71 3 afebrile afebrile JJ cord-297652-ut6e1ysz 71 4 , , , cord-297652-ut6e1ysz 71 5 and and CC cord-297652-ut6e1ysz 71 6 all all DT cord-297652-ut6e1ysz 71 7 symptoms symptom NNS cord-297652-ut6e1ysz 71 8 have have VBP cord-297652-ut6e1ysz 71 9 resolved resolve VBN cord-297652-ut6e1ysz 71 10 with with IN cord-297652-ut6e1ysz 71 11 the the DT cord-297652-ut6e1ysz 71 12 exception exception NN cord-297652-ut6e1ysz 71 13 of of IN cord-297652-ut6e1ysz 71 14 his -PRON- PRP$ cord-297652-ut6e1ysz 71 15 cough cough NN cord-297652-ut6e1ysz 71 16 , , , cord-297652-ut6e1ysz 71 17 which which WDT cord-297652-ut6e1ysz 71 18 is be VBZ cord-297652-ut6e1ysz 71 19 decreasing decrease VBG cord-297652-ut6e1ysz 71 20 in in IN cord-297652-ut6e1ysz 71 21 severity severity NN cord-297652-ut6e1ysz 71 22 . . . cord-297652-ut6e1ysz 71 23 . . . cord-297652-ut6e1ysz 71 24 . . . cord-297652-ut6e1ysz 71 25 . . . cord-297652-ut6e1ysz 72 1 Although although IN cord-297652-ut6e1ysz 72 2 a a DT cord-297652-ut6e1ysz 72 3 decision decision NN cord-297652-ut6e1ysz 72 4 to to TO cord-297652-ut6e1ysz 72 5 administer administer VB cord-297652-ut6e1ysz 72 6 remdesivir remdesivir NNP cord-297652-ut6e1ysz 72 7 for for IN cord-297652-ut6e1ysz 72 8 compassionate compassionate JJ cord-297652-ut6e1ysz 72 9 use use NN cord-297652-ut6e1ysz 72 10 was be VBD cord-297652-ut6e1ysz 72 11 based base VBN cord-297652-ut6e1ysz 72 12 on on IN cord-297652-ut6e1ysz 72 13 the the DT cord-297652-ut6e1ysz 72 14 case case NN cord-297652-ut6e1ysz 72 15 patient patient NN cord-297652-ut6e1ysz 72 16 's 's POS cord-297652-ut6e1ysz 72 17 worsening worsen VBG cord-297652-ut6e1ysz 72 18 clinical clinical JJ cord-297652-ut6e1ysz 72 19 status status NN cord-297652-ut6e1ysz 72 20 , , , cord-297652-ut6e1ysz 72 21 randomized randomized JJ cord-297652-ut6e1ysz 72 22 controlled control VBN cord-297652-ut6e1ysz 72 23 trials trial NNS cord-297652-ut6e1ysz 72 24 are be VBP cord-297652-ut6e1ysz 72 25 needed need VBN cord-297652-ut6e1ysz 72 26 to to TO cord-297652-ut6e1ysz 72 27 determine determine VB cord-297652-ut6e1ysz 72 28 the the DT cord-297652-ut6e1ysz 72 29 safety safety NN cord-297652-ut6e1ysz 72 30 and and CC cord-297652-ut6e1ysz 72 31 efficacy efficacy NN cord-297652-ut6e1ysz 72 32 of of IN cord-297652-ut6e1ysz 72 33 remdesivir remdesivir NNP cord-297652-ut6e1ysz 72 34 and and CC cord-297652-ut6e1ysz 72 35 any any DT cord-297652-ut6e1ysz 72 36 other other JJ cord-297652-ut6e1ysz 72 37 investigational investigational JJ cord-297652-ut6e1ysz 72 38 agents agent NNS cord-297652-ut6e1ysz 72 39 for for IN cord-297652-ut6e1ysz 72 40 treatment treatment NN cord-297652-ut6e1ysz 72 41 of of IN cord-297652-ut6e1ysz 72 42 patients patient NNS cord-297652-ut6e1ysz 72 43 with with IN cord-297652-ut6e1ysz 72 44 2019-nCoV 2019-ncov CD cord-297652-ut6e1ysz 72 45 infection infection NN cord-297652-ut6e1ysz 72 46 . . . cord-297652-ut6e1ysz 72 47 " " '' cord-297652-ut6e1ysz 72 48 . . . cord-297652-ut6e1ysz 73 1 It -PRON- PRP cord-297652-ut6e1ysz 73 2 is be VBZ cord-297652-ut6e1ysz 73 3 actually actually RB cord-297652-ut6e1ysz 73 4 too too RB cord-297652-ut6e1ysz 73 5 early early JJ cord-297652-ut6e1ysz 73 6 to to TO cord-297652-ut6e1ysz 73 7 calculate calculate VB cord-297652-ut6e1ysz 73 8 the the DT cord-297652-ut6e1ysz 73 9 price price NN cord-297652-ut6e1ysz 73 10 of of IN cord-297652-ut6e1ysz 73 11 an an DT cord-297652-ut6e1ysz 73 12 eventual eventual JJ cord-297652-ut6e1ysz 73 13 treatment treatment NN cord-297652-ut6e1ysz 73 14 of of IN cord-297652-ut6e1ysz 73 15 COVID-19 COVID-19 NNP cord-297652-ut6e1ysz 73 16 with with IN cord-297652-ut6e1ysz 73 17 remdesivir remdesivir NNP cord-297652-ut6e1ysz 73 18 , , , cord-297652-ut6e1ysz 73 19 but but CC cord-297652-ut6e1ysz 73 20 some some DT cord-297652-ut6e1ysz 73 21 thoughts thought NNS cord-297652-ut6e1ysz 73 22 can can MD cord-297652-ut6e1ysz 73 23 be be VB cord-297652-ut6e1ysz 73 24 explored explore VBN cord-297652-ut6e1ysz 73 25 . . . cord-297652-ut6e1ysz 74 1 The the DT cord-297652-ut6e1ysz 74 2 dosage dosage NN cord-297652-ut6e1ysz 74 3 that that WDT cord-297652-ut6e1ysz 74 4 will will MD cord-297652-ut6e1ysz 74 5 be be VB cord-297652-ut6e1ysz 74 6 evaluated evaluate VBN cord-297652-ut6e1ysz 74 7 in in IN cord-297652-ut6e1ysz 74 8 the the DT cord-297652-ut6e1ysz 74 9 Discovery Discovery NNP cord-297652-ut6e1ysz 74 10 project project NN cord-297652-ut6e1ysz 74 11 ( ( -LRB- cord-297652-ut6e1ysz 74 12 NCT04315948 NCT04315948 NNP cord-297652-ut6e1ysz 74 13 [ [ -LRB- cord-297652-ut6e1ysz 74 14 4,13 4,13 CD cord-297652-ut6e1ysz 74 15 ] ] -RRB- cord-297652-ut6e1ysz 74 16 ) ) -RRB- cord-297652-ut6e1ysz 74 17 is be VBZ cord-297652-ut6e1ysz 74 18 200 200 CD cord-297652-ut6e1ysz 74 19 mg mg NNP cord-297652-ut6e1ysz 74 20 IV IV NNP cord-297652-ut6e1ysz 74 21 initially initially RB cord-297652-ut6e1ysz 74 22 , , , cord-297652-ut6e1ysz 74 23 then then RB cord-297652-ut6e1ysz 74 24 100 100 CD cord-297652-ut6e1ysz 74 25 mg mg NNP cord-297652-ut6e1ysz 74 26 OD OD NNP cord-297652-ut6e1ysz 74 27 for for IN cord-297652-ut6e1ysz 74 28 2 2 CD cord-297652-ut6e1ysz 74 29 - - SYM cord-297652-ut6e1ysz 74 30 10 10 CD cord-297652-ut6e1ysz 74 31 days day NNS cord-297652-ut6e1ysz 74 32 . . . cord-297652-ut6e1ysz 75 1 The the DT cord-297652-ut6e1ysz 75 2 product product NN cord-297652-ut6e1ysz 75 3 , , , cord-297652-ut6e1ysz 75 4 as as IN cord-297652-ut6e1ysz 75 5 a a DT cord-297652-ut6e1ysz 75 6 research research NN cord-297652-ut6e1ysz 75 7 derivative derivative NN cord-297652-ut6e1ysz 75 8 , , , cord-297652-ut6e1ysz 75 9 is be VBZ cord-297652-ut6e1ysz 75 10 actually actually RB cord-297652-ut6e1ysz 75 11 sold sell VBN cord-297652-ut6e1ysz 75 12 at at IN cord-297652-ut6e1ysz 75 13 854 854 CD cord-297652-ut6e1ysz 75 14 USD usd NN cord-297652-ut6e1ysz 75 15 for for IN cord-297652-ut6e1ysz 75 16 10 10 CD cord-297652-ut6e1ysz 75 17 mg mg NNS cord-297652-ut6e1ysz 75 18 by by IN cord-297652-ut6e1ysz 75 19 MedChemExpress MedChemExpress NNP cord-297652-ut6e1ysz 75 20 ( ( -LRB- cord-297652-ut6e1ysz 75 21 Monmouth Monmouth NNP cord-297652-ut6e1ysz 75 22 Junction Junction NNP cord-297652-ut6e1ysz 75 23 , , , cord-297652-ut6e1ysz 75 24 NJ NJ NNP cord-297652-ut6e1ysz 75 25 , , , cord-297652-ut6e1ysz 75 26 USA USA NNP cord-297652-ut6e1ysz 75 27 ; ; : cord-297652-ut6e1ysz 75 28 cat cat NN cord-297652-ut6e1ysz 75 29 # # NN cord-297652-ut6e1ysz 75 30 HY-104077 hy-104077 NN cord-297652-ut6e1ysz 75 31 ) ) -RRB- cord-297652-ut6e1ysz 76 1 [ [ -LRB- cord-297652-ut6e1ysz 76 2 14 14 CD cord-297652-ut6e1ysz 76 3 ] ] -RRB- cord-297652-ut6e1ysz 76 4 and and CC cord-297652-ut6e1ysz 77 1 330 330 CD cord-297652-ut6e1ysz 77 2 USD usd NN cord-297652-ut6e1ysz 77 3 for for IN cord-297652-ut6e1ysz 77 4 1 1 CD cord-297652-ut6e1ysz 77 5 mg mg NN cord-297652-ut6e1ysz 77 6 by by IN cord-297652-ut6e1ysz 77 7 BioVision BioVision NNP cord-297652-ut6e1ysz 77 8 Inc Inc NNP cord-297652-ut6e1ysz 77 9 ( ( -LRB- cord-297652-ut6e1ysz 77 10 Milpitas Milpitas NNP cord-297652-ut6e1ysz 77 11 , , , cord-297652-ut6e1ysz 77 12 CA CA NNP cord-297652-ut6e1ysz 77 13 , , , cord-297652-ut6e1ysz 77 14 USA USA NNP cord-297652-ut6e1ysz 77 15 ; ; : cord-297652-ut6e1ysz 77 16 cat cat NN cord-297652-ut6e1ysz 77 17 # # $ cord-297652-ut6e1ysz 77 18 B2997 b2997 NN cord-297652-ut6e1ysz 77 19 - - HYPH cord-297652-ut6e1ysz 77 20 1000 1000 CD cord-297652-ut6e1ysz 77 21 ) ) -RRB- cord-297652-ut6e1ysz 78 1 [ [ -LRB- cord-297652-ut6e1ysz 78 2 15 15 CD cord-297652-ut6e1ysz 78 3 ] ] -RRB- cord-297652-ut6e1ysz 78 4 , , , cord-297652-ut6e1ysz 78 5 it -PRON- PRP cord-297652-ut6e1ysz 78 6 is be VBZ cord-297652-ut6e1ysz 78 7 not not RB cord-297652-ut6e1ysz 78 8 pessimistic pessimistic JJ cord-297652-ut6e1ysz 78 9 to to TO cord-297652-ut6e1ysz 78 10 suggest suggest VB cord-297652-ut6e1ysz 78 11 a a DT cord-297652-ut6e1ysz 78 12 retail retail JJ cord-297652-ut6e1ysz 78 13 price price NN cord-297652-ut6e1ysz 78 14 higher high JJR cord-297652-ut6e1ysz 78 15 than than IN cord-297652-ut6e1ysz 78 16 5000 5000 CD cord-297652-ut6e1ysz 78 17 USD usd NN cord-297652-ut6e1ysz 78 18 . . . cord-297652-ut6e1ysz 79 1 The the DT cord-297652-ut6e1ysz 79 2 commercial commercial JJ cord-297652-ut6e1ysz 79 3 combination combination NN cord-297652-ut6e1ysz 79 4 ( ( -LRB- cord-297652-ut6e1ysz 79 5 Kelatra Kelatra NNP cord-297652-ut6e1ysz 79 6 ® ® . cord-297652-ut6e1ysz 79 7 ) ) -RRB- cord-297652-ut6e1ysz 79 8 comprises comprise VBZ cord-297652-ut6e1ysz 79 9 lopinavir lopinavir NNP cord-297652-ut6e1ysz 79 10 and and CC cord-297652-ut6e1ysz 79 11 ritonavir ritonavir NNS cord-297652-ut6e1ysz 79 12 in in IN cord-297652-ut6e1ysz 79 13 a a DT cord-297652-ut6e1ysz 79 14 weight weight NN cord-297652-ut6e1ysz 79 15 ratio ratio NN cord-297652-ut6e1ysz 79 16 4:1 4:1 CD cord-297652-ut6e1ysz 79 17 ; ; : cord-297652-ut6e1ysz 79 18 it -PRON- PRP cord-297652-ut6e1ysz 79 19 is be VBZ cord-297652-ut6e1ysz 79 20 available available JJ cord-297652-ut6e1ysz 79 21 for for IN cord-297652-ut6e1ysz 79 22 the the DT cord-297652-ut6e1ysz 79 23 treatment treatment NN cord-297652-ut6e1ysz 79 24 of of IN cord-297652-ut6e1ysz 79 25 HIV HIV NNP cord-297652-ut6e1ysz 79 26 infection infection NN cord-297652-ut6e1ysz 79 27 . . . cord-297652-ut6e1ysz 80 1 It -PRON- PRP cord-297652-ut6e1ysz 80 2 has have VBZ cord-297652-ut6e1ysz 80 3 been be VBN cord-297652-ut6e1ysz 80 4 the the DT cord-297652-ut6e1ysz 80 5 subject subject NN cord-297652-ut6e1ysz 80 6 of of IN cord-297652-ut6e1ysz 80 7 more more JJR cord-297652-ut6e1ysz 80 8 than than IN cord-297652-ut6e1ysz 80 9 400 400 CD cord-297652-ut6e1ysz 80 10 registered register VBN cord-297652-ut6e1ysz 80 11 clinical clinical JJ cord-297652-ut6e1ysz 80 12 trials trial NNS cord-297652-ut6e1ysz 80 13 [ [ -LRB- cord-297652-ut6e1ysz 80 14 4 4 CD cord-297652-ut6e1ysz 80 15 ] ] -RRB- cord-297652-ut6e1ysz 80 16 . . . cord-297652-ut6e1ysz 81 1 In in IN cord-297652-ut6e1ysz 81 2 vitro vitro FW cord-297652-ut6e1ysz 81 3 , , , cord-297652-ut6e1ysz 81 4 the the DT cord-297652-ut6e1ysz 81 5 combination combination NN cord-297652-ut6e1ysz 81 6 is be VBZ cord-297652-ut6e1ysz 81 7 more more JJR cord-297652-ut6e1ysz 81 8 than than IN cord-297652-ut6e1ysz 81 9 100-fold 100-fold CD cord-297652-ut6e1ysz 81 10 less less RBR cord-297652-ut6e1ysz 81 11 effective effective JJ cord-297652-ut6e1ysz 81 12 than than IN cord-297652-ut6e1ysz 81 13 remdesivir remdesivir NNP cord-297652-ut6e1ysz 81 14 against against IN cord-297652-ut6e1ysz 81 15 strains strain NNS cord-297652-ut6e1ysz 81 16 of of IN cord-297652-ut6e1ysz 81 17 SARS SARS NNP cord-297652-ut6e1ysz 81 18 - - HYPH cord-297652-ut6e1ysz 81 19 CoV CoV NNP cord-297652-ut6e1ysz 81 20 ( ( -LRB- cord-297652-ut6e1ysz 81 21 EC EC NNP cord-297652-ut6e1ysz 81 22 50 50 CD cord-297652-ut6e1ysz 81 23 = = SYM cord-297652-ut6e1ysz 81 24 17.1 17.1 CD cord-297652-ut6e1ysz 81 25 µM µM NFP cord-297652-ut6e1ysz 81 26 [ [ -LRB- cord-297652-ut6e1ysz 81 27 16 16 CD cord-297652-ut6e1ysz 81 28 ] ] -RRB- cord-297652-ut6e1ysz 81 29 ) ) -RRB- cord-297652-ut6e1ysz 81 30 and and CC cord-297652-ut6e1ysz 81 31 MERS MERS NNP cord-297652-ut6e1ysz 81 32 - - HYPH cord-297652-ut6e1ysz 81 33 CoV CoV NNP cord-297652-ut6e1ysz 81 34 ( ( -LRB- cord-297652-ut6e1ysz 81 35 EC EC NNP cord-297652-ut6e1ysz 81 36 50 50 CD cord-297652-ut6e1ysz 81 37 = = SYM cord-297652-ut6e1ysz 81 38 8.0 8.0 CD cord-297652-ut6e1ysz 81 39 µM µM NFP cord-297652-ut6e1ysz 81 40 [ [ -LRB- cord-297652-ut6e1ysz 81 41 16 16 CD cord-297652-ut6e1ysz 81 42 ] ] -RRB- cord-297652-ut6e1ysz 81 43 ) ) -RRB- cord-297652-ut6e1ysz 81 44 . . . cord-297652-ut6e1ysz 82 1 Other other JJ cord-297652-ut6e1ysz 82 2 data datum NNS cord-297652-ut6e1ysz 82 3 indicated indicate VBD cord-297652-ut6e1ysz 82 4 some some DT cord-297652-ut6e1ysz 82 5 success success NN cord-297652-ut6e1ysz 82 6 regarding regard VBG cord-297652-ut6e1ysz 82 7 the the DT cord-297652-ut6e1ysz 82 8 use use NN cord-297652-ut6e1ysz 82 9 of of IN cord-297652-ut6e1ysz 82 10 the the DT cord-297652-ut6e1ysz 82 11 combination combination NN cord-297652-ut6e1ysz 82 12 in in IN cord-297652-ut6e1ysz 82 13 marmosets marmoset NNS cord-297652-ut6e1ysz 82 14 ( ( -LRB- cord-297652-ut6e1ysz 82 15 MERS MERS NNP cord-297652-ut6e1ysz 82 16 ) ) -RRB- cord-297652-ut6e1ysz 82 17 [ [ -LRB- cord-297652-ut6e1ysz 82 18 17 17 CD cord-297652-ut6e1ysz 82 19 ] ] -RRB- cord-297652-ut6e1ysz 82 20 and and CC cord-297652-ut6e1ysz 82 21 in in IN cord-297652-ut6e1ysz 82 22 infected infected JJ cord-297652-ut6e1ysz 82 23 human human JJ cord-297652-ut6e1ysz 82 24 patients patient NNS cord-297652-ut6e1ysz 82 25 ( ( -LRB- cord-297652-ut6e1ysz 82 26 SARS SARS NNP cord-297652-ut6e1ysz 82 27 as as RB cord-297652-ut6e1ysz 82 28 well well RB cord-297652-ut6e1ysz 82 29 as as IN cord-297652-ut6e1ysz 82 30 MERS MERS NNP cord-297652-ut6e1ysz 82 31 ) ) -RRB- cord-297652-ut6e1ysz 82 32 [ [ -LRB- cord-297652-ut6e1ysz 82 33 18 18 CD cord-297652-ut6e1ysz 82 34 ] ] -RRB- cord-297652-ut6e1ysz 82 35 . . . cord-297652-ut6e1ysz 83 1 However however RB cord-297652-ut6e1ysz 83 2 , , , cord-297652-ut6e1ysz 83 3 some some DT cord-297652-ut6e1ysz 83 4 authors author NNS cord-297652-ut6e1ysz 83 5 remain remain VBP cord-297652-ut6e1ysz 83 6 skeptical skeptical JJ cord-297652-ut6e1ysz 83 7 and and CC cord-297652-ut6e1ysz 83 8 are be VBP cord-297652-ut6e1ysz 83 9 not not RB cord-297652-ut6e1ysz 83 10 confident confident JJ cord-297652-ut6e1ysz 83 11 in in IN cord-297652-ut6e1ysz 83 12 the the DT cord-297652-ut6e1ysz 83 13 success success NN cord-297652-ut6e1ysz 83 14 of of IN cord-297652-ut6e1ysz 83 15 Kelatra Kelatra NNP cord-297652-ut6e1ysz 84 1 ® ® VB cord-297652-ut6e1ysz 84 2 for for IN cord-297652-ut6e1ysz 84 3 treating treat VBG cord-297652-ut6e1ysz 84 4 COVID-19 covid-19 ADD cord-297652-ut6e1ysz 84 5 [ [ -LRB- cord-297652-ut6e1ysz 84 6 19 19 CD cord-297652-ut6e1ysz 84 7 ] ] -RRB- cord-297652-ut6e1ysz 84 8 [ [ -LRB- cord-297652-ut6e1ysz 84 9 20 20 CD cord-297652-ut6e1ysz 84 10 ] ] -RRB- cord-297652-ut6e1ysz 84 11 [ [ -LRB- cord-297652-ut6e1ysz 84 12 21 21 CD cord-297652-ut6e1ysz 84 13 ] ] -RRB- cord-297652-ut6e1ysz 84 14 [ [ -LRB- cord-297652-ut6e1ysz 84 15 22 22 CD cord-297652-ut6e1ysz 84 16 ] ] -RRB- cord-297652-ut6e1ysz 84 17 . . . cord-297652-ut6e1ysz 85 1 In in IN cord-297652-ut6e1ysz 85 2 the the DT cord-297652-ut6e1ysz 85 3 Discovery Discovery NNP cord-297652-ut6e1ysz 85 4 project project NN cord-297652-ut6e1ysz 85 5 ( ( -LRB- cord-297652-ut6e1ysz 85 6 NCT04315948 NCT04315948 NNP cord-297652-ut6e1ysz 85 7 [ [ -LRB- cord-297652-ut6e1ysz 85 8 4,13 4,13 CD cord-297652-ut6e1ysz 85 9 ] ] -RRB- cord-297652-ut6e1ysz 85 10 ) ) -RRB- cord-297652-ut6e1ysz 86 1 , , , cord-297652-ut6e1ysz 86 2 the the DT cord-297652-ut6e1ysz 86 3 suggested suggested JJ cord-297652-ut6e1ysz 86 4 dose dose NN cord-297652-ut6e1ysz 86 5 of of IN cord-297652-ut6e1ysz 86 6 the the DT cord-297652-ut6e1ysz 86 7 combination combination NN cord-297652-ut6e1ysz 86 8 is be VBZ cord-297652-ut6e1ysz 86 9 500 500 CD cord-297652-ut6e1ysz 86 10 mg mg NN cord-297652-ut6e1ysz 86 11 ( ( -LRB- cord-297652-ut6e1ysz 87 1 400 400 CD cord-297652-ut6e1ysz 87 2 mg mg NNP cord-297652-ut6e1ysz 87 3 lopinavir lopinavir NNS cord-297652-ut6e1ysz 87 4 + + CC cord-297652-ut6e1ysz 88 1 100 100 CD cord-297652-ut6e1ysz 88 2 mg mg NNP cord-297652-ut6e1ysz 88 3 ritonavir ritonavir NNP cord-297652-ut6e1ysz 88 4 ) ) -RRB- cord-297652-ut6e1ysz 89 1 every every DT cord-297652-ut6e1ysz 89 2 12 12 CD cord-297652-ut6e1ysz 89 3 h h NN cord-297652-ut6e1ysz 89 4 for for IN cord-297652-ut6e1ysz 89 5 14 14 CD cord-297652-ut6e1ysz 89 6 days day NNS cord-297652-ut6e1ysz 89 7 . . . cord-297652-ut6e1ysz 90 1 On on IN cord-297652-ut6e1ysz 90 2 the the DT cord-297652-ut6e1ysz 90 3 basis basis NN cord-297652-ut6e1ysz 90 4 of of IN cord-297652-ut6e1ysz 90 5 the the DT cord-297652-ut6e1ysz 90 6 lowest low JJS cord-297652-ut6e1ysz 90 7 retail retail JJ cord-297652-ut6e1ysz 90 8 price price NN cord-297652-ut6e1ysz 90 9 found find VBN cord-297652-ut6e1ysz 90 10 on on IN cord-297652-ut6e1ysz 90 11 the the DT cord-297652-ut6e1ysz 90 12 website website NN cord-297652-ut6e1ysz 90 13 PharmacyChercker.com PharmacyChercker.com NNP cord-297652-ut6e1ysz 90 14 [ [ -LRB- cord-297652-ut6e1ysz 90 15 23 23 CD cord-297652-ut6e1ysz 90 16 ] ] -RRB- cord-297652-ut6e1ysz 90 17 , , , cord-297652-ut6e1ysz 90 18 the the DT cord-297652-ut6e1ysz 90 19 cost cost NN cord-297652-ut6e1ysz 90 20 of of IN cord-297652-ut6e1ysz 90 21 the the DT cord-297652-ut6e1ysz 90 22 treatment treatment NN cord-297652-ut6e1ysz 90 23 , , , cord-297652-ut6e1ysz 90 24 if if IN cord-297652-ut6e1ysz 90 25 the the DT cord-297652-ut6e1ysz 90 26 drug drug NN cord-297652-ut6e1ysz 90 27 combination combination NN cord-297652-ut6e1ysz 90 28 proves prove VBZ cord-297652-ut6e1ysz 90 29 to to TO cord-297652-ut6e1ysz 90 30 be be VB cord-297652-ut6e1ysz 90 31 efficacious efficacious JJ cord-297652-ut6e1ysz 90 32 in in IN cord-297652-ut6e1ysz 90 33 humans human NNS cord-297652-ut6e1ysz 90 34 , , , cord-297652-ut6e1ysz 90 35 should should MD cord-297652-ut6e1ysz 90 36 be be VB cord-297652-ut6e1ysz 90 37 estimated estimate VBN cord-297652-ut6e1ysz 90 38 at at IN cord-297652-ut6e1ysz 90 39 61 61 CD cord-297652-ut6e1ysz 90 40 USD usd NN cord-297652-ut6e1ysz 90 41 for for IN cord-297652-ut6e1ysz 90 42 the the DT cord-297652-ut6e1ysz 90 43 generic generic JJ cord-297652-ut6e1ysz 90 44 and and CC cord-297652-ut6e1ysz 90 45 215 215 CD cord-297652-ut6e1ysz 90 46 USD usd NN cord-297652-ut6e1ysz 90 47 for for IN cord-297652-ut6e1ysz 90 48 the the DT cord-297652-ut6e1ysz 90 49 original original JJ cord-297652-ut6e1ysz 90 50 brand brand NN cord-297652-ut6e1ysz 90 51 . . . cord-297652-ut6e1ysz 91 1 Interferon Interferon NNP cord-297652-ut6e1ysz 91 2 β-1a β-1a NN cord-297652-ut6e1ysz 91 3 is be VBZ cord-297652-ut6e1ysz 91 4 an an DT cord-297652-ut6e1ysz 91 5 efficient efficient JJ cord-297652-ut6e1ysz 91 6 inhibitor inhibitor NN cord-297652-ut6e1ysz 91 7 of of IN cord-297652-ut6e1ysz 91 8 the the DT cord-297652-ut6e1ysz 91 9 multiplication multiplication NN cord-297652-ut6e1ysz 91 10 of of IN cord-297652-ut6e1ysz 91 11 SARS SARS NNP cord-297652-ut6e1ysz 91 12 - - HYPH cord-297652-ut6e1ysz 91 13 CoV CoV NNP cord-297652-ut6e1ysz 91 14 [ [ -LRB- cord-297652-ut6e1ysz 91 15 24 24 CD cord-297652-ut6e1ysz 91 16 , , , cord-297652-ut6e1ysz 91 17 25 25 CD cord-297652-ut6e1ysz 91 18 ] ] -RRB- cord-297652-ut6e1ysz 91 19 and and CC cord-297652-ut6e1ysz 91 20 MERS MERS NNP cord-297652-ut6e1ysz 91 21 - - HYPH cord-297652-ut6e1ysz 91 22 CoV CoV NNP cord-297652-ut6e1ysz 91 23 [ [ -LRB- cord-297652-ut6e1ysz 91 24 26 26 CD cord-297652-ut6e1ysz 91 25 ] ] -RRB- cord-297652-ut6e1ysz 91 26 in in IN cord-297652-ut6e1ysz 91 27 cell cell NN cord-297652-ut6e1ysz 91 28 cultures culture NNS cord-297652-ut6e1ysz 91 29 . . . cord-297652-ut6e1ysz 92 1 In in IN cord-297652-ut6e1ysz 92 2 a a DT cord-297652-ut6e1ysz 92 3 MERS MERS NNP cord-297652-ut6e1ysz 92 4 - - HYPH cord-297652-ut6e1ysz 92 5 CoV CoV NNP cord-297652-ut6e1ysz 92 6 mouse mouse NN cord-297652-ut6e1ysz 92 7 model model NN cord-297652-ut6e1ysz 92 8 , , , cord-297652-ut6e1ysz 92 9 the the DT cord-297652-ut6e1ysz 92 10 combination combination NN cord-297652-ut6e1ysz 92 11 lopinavir lopinavir NNP cord-297652-ut6e1ysz 92 12 / / SYM cord-297652-ut6e1ysz 92 13 ritonavir ritonavir NNP cord-297652-ut6e1ysz 92 14 / / SYM cord-297652-ut6e1ysz 92 15 interferon interferon NNP cord-297652-ut6e1ysz 92 16 β-1a β-1a NNP cord-297652-ut6e1ysz 92 17 , , , cord-297652-ut6e1ysz 92 18 used use VBN cord-297652-ut6e1ysz 92 19 as as IN cord-297652-ut6e1ysz 92 20 prophylactic prophylactic JJ cord-297652-ut6e1ysz 92 21 and and CC cord-297652-ut6e1ysz 92 22 curative curative JJ cord-297652-ut6e1ysz 92 23 treatments treatment NNS cord-297652-ut6e1ysz 92 24 , , , cord-297652-ut6e1ysz 92 25 revealed reveal VBD cord-297652-ut6e1ysz 92 26 no no DT cord-297652-ut6e1ysz 92 27 significant significant JJ cord-297652-ut6e1ysz 92 28 decrease decrease NN cord-297652-ut6e1ysz 92 29 in in IN cord-297652-ut6e1ysz 92 30 the the DT cord-297652-ut6e1ysz 92 31 viral viral JJ cord-297652-ut6e1ysz 92 32 load load NN cord-297652-ut6e1ysz 92 33 [ [ -LRB- cord-297652-ut6e1ysz 92 34 9 9 CD cord-297652-ut6e1ysz 92 35 ] ] -RRB- cord-297652-ut6e1ysz 92 36 . . . cord-297652-ut6e1ysz 93 1 In in IN cord-297652-ut6e1ysz 93 2 a a DT cord-297652-ut6e1ysz 93 3 marmoset marmoset JJ cord-297652-ut6e1ysz 93 4 model model NN cord-297652-ut6e1ysz 93 5 [ [ -LRB- cord-297652-ut6e1ysz 93 6 17 17 CD cord-297652-ut6e1ysz 93 7 ] ] -RRB- cord-297652-ut6e1ysz 93 8 , , , cord-297652-ut6e1ysz 93 9 the the DT cord-297652-ut6e1ysz 93 10 combination combination NN cord-297652-ut6e1ysz 93 11 lopinavir lopinavir NNP cord-297652-ut6e1ysz 93 12 / / SYM cord-297652-ut6e1ysz 93 13 ritonavir ritonavir NNP cord-297652-ut6e1ysz 93 14 / / SYM cord-297652-ut6e1ysz 93 15 interferon interferon NNP cord-297652-ut6e1ysz 93 16 β-1b β-1b NNP cord-297652-ut6e1ysz 93 17 ( ( -LRB- cord-297652-ut6e1ysz 93 18 bacterial bacterial JJ cord-297652-ut6e1ysz 93 19 origin origin NN cord-297652-ut6e1ysz 93 20 , , , cord-297652-ut6e1ysz 93 21 whereas whereas IN cord-297652-ut6e1ysz 93 22 interferon interferon NNP cord-297652-ut6e1ysz 93 23 β-1a β-1a NNP cord-297652-ut6e1ysz 93 24 is be VBZ cord-297652-ut6e1ysz 93 25 produced produce VBN cord-297652-ut6e1ysz 93 26 by by IN cord-297652-ut6e1ysz 93 27 Chinese chinese JJ cord-297652-ut6e1ysz 93 28 hamster hamster NN cord-297652-ut6e1ysz 93 29 ovary ovary NN cord-297652-ut6e1ysz 93 30 cells cell NNS cord-297652-ut6e1ysz 93 31 [ [ -LRB- cord-297652-ut6e1ysz 93 32 27 27 CD cord-297652-ut6e1ysz 93 33 ] ] -RRB- cord-297652-ut6e1ysz 93 34 ) ) -RRB- cord-297652-ut6e1ysz 93 35 opened open VBD cord-297652-ut6e1ysz 93 36 some some DT cord-297652-ut6e1ysz 93 37 hope hope NN cord-297652-ut6e1ysz 93 38 for for IN cord-297652-ut6e1ysz 93 39 curing cure VBG cord-297652-ut6e1ysz 93 40 MERS MERS NNP cord-297652-ut6e1ysz 93 41 - - HYPH cord-297652-ut6e1ysz 93 42 CoV cov NN cord-297652-ut6e1ysz 93 43 - - HYPH cord-297652-ut6e1ysz 93 44 infected infect VBN cord-297652-ut6e1ysz 93 45 animals animal NNS cord-297652-ut6e1ysz 93 46 . . . cord-297652-ut6e1ysz 94 1 The the DT cord-297652-ut6e1ysz 94 2 results result NNS cord-297652-ut6e1ysz 94 3 of of IN cord-297652-ut6e1ysz 94 4 an an DT cord-297652-ut6e1ysz 94 5 ongoing ongoing JJ cord-297652-ut6e1ysz 94 6 clinical clinical JJ cord-297652-ut6e1ysz 94 7 trial trial NN cord-297652-ut6e1ysz 94 8 ( ( -LRB- cord-297652-ut6e1ysz 94 9 NCT NCT NNP cord-297652-ut6e1ysz 94 10 Pharmaceuticals Pharmaceuticals NNPS cord-297652-ut6e1ysz 94 11 2020 2020 CD cord-297652-ut6e1ysz 94 12 , , , cord-297652-ut6e1ysz 94 13 13 13 CD cord-297652-ut6e1ysz 94 14 , , , cord-297652-ut6e1ysz 94 15 65 65 CD cord-297652-ut6e1ysz 94 16 5 5 CD cord-297652-ut6e1ysz 94 17 of of IN cord-297652-ut6e1ysz 94 18 8 8 CD cord-297652-ut6e1ysz 94 19 02845843 02845843 CD cord-297652-ut6e1ysz 94 20 [ [ -LRB- cord-297652-ut6e1ysz 94 21 4 4 CD cord-297652-ut6e1ysz 94 22 ] ] -RRB- cord-297652-ut6e1ysz 94 23 ) ) -RRB- cord-297652-ut6e1ysz 94 24 , , , cord-297652-ut6e1ysz 94 25 entitled entitle VBN cord-297652-ut6e1ysz 94 26 " " `` cord-297652-ut6e1ysz 94 27 MERS MERS NNP cord-297652-ut6e1ysz 94 28 - - HYPH cord-297652-ut6e1ysz 94 29 CoV cov NN cord-297652-ut6e1ysz 94 30 infection infection NN cord-297652-ut6e1ysz 94 31 treated treat VBN cord-297652-ut6e1ysz 94 32 with with IN cord-297652-ut6e1ysz 94 33 a a DT cord-297652-ut6e1ysz 94 34 combination combination NN cord-297652-ut6e1ysz 94 35 of of IN cord-297652-ut6e1ysz 94 36 lopinavir lopinavir NNS cord-297652-ut6e1ysz 94 37 / / SYM cord-297652-ut6e1ysz 94 38 ritonavir ritonavir NNS cord-297652-ut6e1ysz 94 39 and and CC cord-297652-ut6e1ysz 94 40 interferon interferon NN cord-297652-ut6e1ysz 94 41 Beta-1b Beta-1b NNP cord-297652-ut6e1ysz 94 42 " " '' cord-297652-ut6e1ysz 94 43 , , , cord-297652-ut6e1ysz 94 44 are be VBP cord-297652-ut6e1ysz 94 45 eagerly eagerly RB cord-297652-ut6e1ysz 94 46 awaited await VBN cord-297652-ut6e1ysz 94 47 , , , cord-297652-ut6e1ysz 94 48 but but CC cord-297652-ut6e1ysz 94 49 will will MD cord-297652-ut6e1ysz 94 50 not not RB cord-297652-ut6e1ysz 94 51 be be VB cord-297652-ut6e1ysz 94 52 disclosed disclose VBN cord-297652-ut6e1ysz 94 53 before before IN cord-297652-ut6e1ysz 94 54 2021 2021 CD cord-297652-ut6e1ysz 94 55 . . . cord-297652-ut6e1ysz 95 1 The the DT cord-297652-ut6e1ysz 95 2 study study NN cord-297652-ut6e1ysz 95 3 suggested suggest VBD cord-297652-ut6e1ysz 95 4 a a DT cord-297652-ut6e1ysz 95 5 dose dose NN cord-297652-ut6e1ysz 95 6 of of IN cord-297652-ut6e1ysz 95 7 lopinavir lopinavir NNS cord-297652-ut6e1ysz 95 8 / / SYM cord-297652-ut6e1ysz 95 9 ritonavir ritonavir NNP cord-297652-ut6e1ysz 95 10 ( ( -LRB- cord-297652-ut6e1ysz 95 11 400/100 400/100 CD cord-297652-ut6e1ysz 95 12 mg mg NNP cord-297652-ut6e1ysz 95 13 ) ) -RRB- cord-297652-ut6e1ysz 95 14 twice twice RB cord-297652-ut6e1ysz 95 15 daily daily RB cord-297652-ut6e1ysz 95 16 for for IN cord-297652-ut6e1ysz 95 17 14 14 CD cord-297652-ut6e1ysz 95 18 days day NNS cord-297652-ut6e1ysz 95 19 , , , cord-297652-ut6e1ysz 95 20 and and CC cord-297652-ut6e1ysz 95 21 interferon interferon NN cord-297652-ut6e1ysz 95 22 β-1b β-1b . cord-297652-ut6e1ysz 96 1 0.25 0.25 CD cord-297652-ut6e1ysz 96 2 mg mg NN cord-297652-ut6e1ysz 96 3 subcutaneous subcutaneous JJ cord-297652-ut6e1ysz 96 4 every every DT cord-297652-ut6e1ysz 96 5 alternate alternate JJ cord-297652-ut6e1ysz 96 6 day day NN cord-297652-ut6e1ysz 96 7 for for IN cord-297652-ut6e1ysz 96 8 14 14 CD cord-297652-ut6e1ysz 96 9 days day NNS cord-297652-ut6e1ysz 96 10 [ [ -LRB- cord-297652-ut6e1ysz 96 11 4 4 CD cord-297652-ut6e1ysz 96 12 ] ] -RRB- cord-297652-ut6e1ysz 96 13 . . . cord-297652-ut6e1ysz 97 1 Interferon interferon NN cord-297652-ut6e1ysz 97 2 β-1a β-1a NN cord-297652-ut6e1ysz 97 3 is be VBZ cord-297652-ut6e1ysz 97 4 clinically clinically RB cord-297652-ut6e1ysz 97 5 used use VBN cord-297652-ut6e1ysz 97 6 for for IN cord-297652-ut6e1ysz 97 7 the the DT cord-297652-ut6e1ysz 97 8 treatment treatment NN cord-297652-ut6e1ysz 97 9 of of IN cord-297652-ut6e1ysz 97 10 relapsing relapse VBG cord-297652-ut6e1ysz 97 11 multiple multiple JJ cord-297652-ut6e1ysz 97 12 sclerosis sclerosis NN cord-297652-ut6e1ysz 97 13 . . . cord-297652-ut6e1ysz 98 1 It -PRON- PRP cord-297652-ut6e1ysz 98 2 was be VBD cord-297652-ut6e1ysz 98 3 approved approve VBN cord-297652-ut6e1ysz 98 4 by by IN cord-297652-ut6e1ysz 98 5 the the DT cord-297652-ut6e1ysz 98 6 FDA FDA NNP cord-297652-ut6e1ysz 98 7 on on IN cord-297652-ut6e1ysz 98 8 05/17/1996 05/17/1996 CD cord-297652-ut6e1ysz 98 9 under under IN cord-297652-ut6e1ysz 98 10 the the DT cord-297652-ut6e1ysz 98 11 brand brand NN cord-297652-ut6e1ysz 98 12 name name NN cord-297652-ut6e1ysz 98 13 Avonex Avonex NNP cord-297652-ut6e1ysz 98 14 ® ® , cord-297652-ut6e1ysz 98 15 and and CC cord-297652-ut6e1ysz 98 16 is be VBZ cord-297652-ut6e1ysz 98 17 sold sell VBN cord-297652-ut6e1ysz 98 18 by by IN cord-297652-ut6e1ysz 98 19 Biogen Biogen NNP cord-297652-ut6e1ysz 98 20 under under IN cord-297652-ut6e1ysz 98 21 the the DT cord-297652-ut6e1ysz 98 22 Orphan Orphan NNP cord-297652-ut6e1ysz 98 23 Drug Drug NNP cord-297652-ut6e1ysz 98 24 designation designation NN cord-297652-ut6e1ysz 98 25 . . . cord-297652-ut6e1ysz 99 1 It -PRON- PRP cord-297652-ut6e1ysz 99 2 is be VBZ cord-297652-ut6e1ysz 99 3 also also RB cord-297652-ut6e1ysz 99 4 known know VBN cord-297652-ut6e1ysz 99 5 as as IN cord-297652-ut6e1ysz 99 6 Rebif Rebif NNP cord-297652-ut6e1ysz 100 1 ® ® VBG cord-297652-ut6e1ysz 100 2 from from IN cord-297652-ut6e1ysz 100 3 Serono Serono NNP cord-297652-ut6e1ysz 100 4 Inc Inc NNP cord-297652-ut6e1ysz 100 5 ( ( -LRB- cord-297652-ut6e1ysz 100 6 FDA FDA NNP cord-297652-ut6e1ysz 100 7 - - HYPH cord-297652-ut6e1ysz 100 8 approved approve VBN cord-297652-ut6e1ysz 100 9 on on IN cord-297652-ut6e1ysz 100 10 03/07/2002 03/07/2002 CD cord-297652-ut6e1ysz 100 11 ) ) -RRB- cord-297652-ut6e1ysz 100 12 . . . cord-297652-ut6e1ysz 101 1 In in IN cord-297652-ut6e1ysz 101 2 the the DT cord-297652-ut6e1ysz 101 3 Discovery Discovery NNP cord-297652-ut6e1ysz 101 4 project project NN cord-297652-ut6e1ysz 101 5 , , , cord-297652-ut6e1ysz 101 6 interferon interferon NNP cord-297652-ut6e1ysz 101 7 β-1a β-1a NNP cord-297652-ut6e1ysz 101 8 will will MD cord-297652-ut6e1ysz 101 9 be be VB cord-297652-ut6e1ysz 101 10 added add VBN cord-297652-ut6e1ysz 101 11 to to IN cord-297652-ut6e1ysz 101 12 the the DT cord-297652-ut6e1ysz 101 13 treatment treatment NN cord-297652-ut6e1ysz 101 14 lopinavir lopinavir NNS cord-297652-ut6e1ysz 101 15 / / SYM cord-297652-ut6e1ysz 101 16 ritonavir ritonavir NNP cord-297652-ut6e1ysz 101 17 ( ( -LRB- cord-297652-ut6e1ysz 101 18 see see VB cord-297652-ut6e1ysz 101 19 Section section NN cord-297652-ut6e1ysz 101 20 4.2 4.2 CD cord-297652-ut6e1ysz 101 21 ) ) -RRB- cord-297652-ut6e1ysz 101 22 and and CC cord-297652-ut6e1ysz 101 23 administered administer VBD cord-297652-ut6e1ysz 101 24 subcutaneously subcutaneously RB cord-297652-ut6e1ysz 101 25 at at IN cord-297652-ut6e1ysz 101 26 the the DT cord-297652-ut6e1ysz 101 27 dose dose NN cord-297652-ut6e1ysz 101 28 of of IN cord-297652-ut6e1ysz 101 29 44 44 CD cord-297652-ut6e1ysz 101 30 µg µg NNS cord-297652-ut6e1ysz 101 31 for for IN cord-297652-ut6e1ysz 101 32 a a DT cord-297652-ut6e1ysz 101 33 total total NN cord-297652-ut6e1ysz 101 34 of of IN cord-297652-ut6e1ysz 101 35 three three CD cord-297652-ut6e1ysz 101 36 doses dose NNS cord-297652-ut6e1ysz 101 37 in in IN cord-297652-ut6e1ysz 101 38 6 6 CD cord-297652-ut6e1ysz 101 39 days day NNS cord-297652-ut6e1ysz 101 40 . . . cord-297652-ut6e1ysz 102 1 That that DT cord-297652-ut6e1ysz 102 2 will will MD cord-297652-ut6e1ysz 102 3 represent represent VB cord-297652-ut6e1ysz 102 4 an an DT cord-297652-ut6e1ysz 102 5 additional additional JJ cord-297652-ut6e1ysz 102 6 cost cost NN cord-297652-ut6e1ysz 102 7 of of IN cord-297652-ut6e1ysz 102 8 almost almost RB cord-297652-ut6e1ysz 102 9 2000 2000 CD cord-297652-ut6e1ysz 102 10 USD usd NN cord-297652-ut6e1ysz 102 11 for for IN cord-297652-ut6e1ysz 102 12 Rebif Rebif NNP cord-297652-ut6e1ysz 103 1 ® ® NNP cord-297652-ut6e1ysz 103 2 , , , cord-297652-ut6e1ysz 103 3 following follow VBG cord-297652-ut6e1ysz 103 4 [ [ -LRB- cord-297652-ut6e1ysz 103 5 23 23 CD cord-297652-ut6e1ysz 103 6 ] ] -RRB- cord-297652-ut6e1ysz 103 7 . . . cord-297652-ut6e1ysz 104 1 There there EX cord-297652-ut6e1ysz 104 2 is be VBZ cord-297652-ut6e1ysz 104 3 a a DT cord-297652-ut6e1ysz 104 4 huge huge JJ cord-297652-ut6e1ysz 104 5 confusion confusion NN cord-297652-ut6e1ysz 104 6 in in IN cord-297652-ut6e1ysz 104 7 the the DT cord-297652-ut6e1ysz 104 8 public public NN cord-297652-ut6e1ysz 104 9 , , , cord-297652-ut6e1ysz 104 10 as as RB cord-297652-ut6e1ysz 104 11 well well RB cord-297652-ut6e1ysz 104 12 as as IN cord-297652-ut6e1ysz 104 13 among among IN cord-297652-ut6e1ysz 104 14 politicians politician NNS cord-297652-ut6e1ysz 104 15 and and CC cord-297652-ut6e1ysz 104 16 even even RB cord-297652-ut6e1ysz 104 17 some some DT cord-297652-ut6e1ysz 104 18 scientists scientist NNS cord-297652-ut6e1ysz 104 19 , , , cord-297652-ut6e1ysz 104 20 about about IN cord-297652-ut6e1ysz 104 21 those those DT cord-297652-ut6e1ysz 104 22 two two CD cord-297652-ut6e1ysz 104 23 molecules molecule NNS cord-297652-ut6e1ysz 104 24 . . . cord-297652-ut6e1ysz 105 1 That that DT cord-297652-ut6e1ysz 105 2 confusion confusion NN cord-297652-ut6e1ysz 105 3 ultimately ultimately RB cord-297652-ut6e1ysz 105 4 led lead VBD cord-297652-ut6e1ysz 105 5 to to IN cord-297652-ut6e1ysz 105 6 people people NNS cord-297652-ut6e1ysz 105 7 accidently accidently RB cord-297652-ut6e1ysz 105 8 overdosing overdose VBG cord-297652-ut6e1ysz 105 9 [ [ -LRB- cord-297652-ut6e1ysz 105 10 28 28 CD cord-297652-ut6e1ysz 105 11 ] ] -RRB- cord-297652-ut6e1ysz 105 12 . . . cord-297652-ut6e1ysz 106 1 Both both DT cord-297652-ut6e1ysz 106 2 molecules molecule NNS cord-297652-ut6e1ysz 106 3 can can MD cord-297652-ut6e1ysz 106 4 be be VB cord-297652-ut6e1ysz 106 5 classified classify VBN cord-297652-ut6e1ysz 106 6 as as IN cord-297652-ut6e1ysz 106 7 4-aminoquinolines 4-aminoquinolines CD cord-297652-ut6e1ysz 106 8 , , , cord-297652-ut6e1ysz 106 9 and and CC cord-297652-ut6e1ysz 106 10 both both DT cord-297652-ut6e1ysz 106 11 have have VBP cord-297652-ut6e1ysz 106 12 anti anti JJ cord-297652-ut6e1ysz 106 13 - - JJ cord-297652-ut6e1ysz 106 14 plasmodial plasmodial JJ cord-297652-ut6e1ysz 106 15 activities activity NNS cord-297652-ut6e1ysz 106 16 , , , cord-297652-ut6e1ysz 106 17 but but CC cord-297652-ut6e1ysz 106 18 they -PRON- PRP cord-297652-ut6e1ysz 106 19 remain remain VBP cord-297652-ut6e1ysz 106 20 two two CD cord-297652-ut6e1ysz 106 21 different different JJ cord-297652-ut6e1ysz 106 22 molecules molecule NNS cord-297652-ut6e1ysz 106 23 with with IN cord-297652-ut6e1ysz 106 24 some some DT cord-297652-ut6e1ysz 106 25 different different JJ cord-297652-ut6e1ysz 106 26 metabolites metabolite NNS cord-297652-ut6e1ysz 106 27 . . . cord-297652-ut6e1ysz 107 1 Chloroquine Chloroquine NNP cord-297652-ut6e1ysz 107 2 has have VBZ cord-297652-ut6e1ysz 107 3 been be VBN cord-297652-ut6e1ysz 107 4 widely widely RB cord-297652-ut6e1ysz 107 5 used use VBN cord-297652-ut6e1ysz 107 6 since since IN cord-297652-ut6e1ysz 107 7 the the DT cord-297652-ut6e1ysz 107 8 1950s 1950 NNS cord-297652-ut6e1ysz 107 9 for for IN cord-297652-ut6e1ysz 107 10 prophylactic prophylactic JJ cord-297652-ut6e1ysz 107 11 and and CC cord-297652-ut6e1ysz 107 12 curative curative JJ cord-297652-ut6e1ysz 107 13 treatments treatment NNS cord-297652-ut6e1ysz 107 14 of of IN cord-297652-ut6e1ysz 107 15 malaria malaria NN cord-297652-ut6e1ysz 107 16 . . . cord-297652-ut6e1ysz 108 1 Its -PRON- PRP$ cord-297652-ut6e1ysz 108 2 extensive extensive JJ cord-297652-ut6e1ysz 108 3 use use NN cord-297652-ut6e1ysz 108 4 has have VBZ cord-297652-ut6e1ysz 108 5 led lead VBN cord-297652-ut6e1ysz 108 6 to to IN cord-297652-ut6e1ysz 108 7 the the DT cord-297652-ut6e1ysz 108 8 emergence emergence NN cord-297652-ut6e1ysz 108 9 of of IN cord-297652-ut6e1ysz 108 10 chloroquine chloroquine NN cord-297652-ut6e1ysz 108 11 - - HYPH cord-297652-ut6e1ysz 108 12 resistant resistant JJ cord-297652-ut6e1ysz 108 13 strains strain NNS cord-297652-ut6e1ysz 108 14 of of IN cord-297652-ut6e1ysz 108 15 Plasmodium Plasmodium NNP cord-297652-ut6e1ysz 108 16 falciparum falciparum NN cord-297652-ut6e1ysz 108 17 , , , cord-297652-ut6e1ysz 108 18 the the DT cord-297652-ut6e1ysz 108 19 parasite parasite NN cord-297652-ut6e1ysz 108 20 responsible responsible JJ cord-297652-ut6e1ysz 108 21 for for IN cord-297652-ut6e1ysz 108 22 the the DT cord-297652-ut6e1ysz 108 23 severest severe JJS cord-297652-ut6e1ysz 108 24 form form NN cord-297652-ut6e1ysz 108 25 of of IN cord-297652-ut6e1ysz 108 26 malaria malaria NN cord-297652-ut6e1ysz 108 27 . . . cord-297652-ut6e1ysz 109 1 Such such JJ cord-297652-ut6e1ysz 109 2 strains strain NNS cord-297652-ut6e1ysz 109 3 are be VBP cord-297652-ut6e1ysz 109 4 also also RB cord-297652-ut6e1ysz 109 5 resistant resistant JJ cord-297652-ut6e1ysz 109 6 to to IN cord-297652-ut6e1ysz 109 7 the the DT cord-297652-ut6e1ysz 109 8 structurally structurally RB cord-297652-ut6e1ysz 109 9 related relate VBN cord-297652-ut6e1ysz 109 10 hydroxychloroquine hydroxychloroquine NN cord-297652-ut6e1ysz 109 11 . . . cord-297652-ut6e1ysz 110 1 Regardless regardless RB cord-297652-ut6e1ysz 110 2 , , , cord-297652-ut6e1ysz 110 3 the the DT cord-297652-ut6e1ysz 110 4 latter latter JJ cord-297652-ut6e1ysz 110 5 is be VBZ cord-297652-ut6e1ysz 110 6 sometimes sometimes RB cord-297652-ut6e1ysz 110 7 preferred prefer VBN cord-297652-ut6e1ysz 110 8 because because IN cord-297652-ut6e1ysz 110 9 of of IN cord-297652-ut6e1ysz 110 10 its -PRON- PRP$ cord-297652-ut6e1ysz 110 11 lower low JJR cord-297652-ut6e1ysz 110 12 ( ( -LRB- cord-297652-ut6e1ysz 110 13 retinal retinal JJ cord-297652-ut6e1ysz 110 14 ) ) -RRB- cord-297652-ut6e1ysz 110 15 toxicity toxicity NN cord-297652-ut6e1ysz 110 16 [ [ -LRB- cord-297652-ut6e1ysz 110 17 29 29 CD cord-297652-ut6e1ysz 110 18 , , , cord-297652-ut6e1ysz 110 19 30 30 CD cord-297652-ut6e1ysz 110 20 ] ] -RRB- cord-297652-ut6e1ysz 110 21 . . . cord-297652-ut6e1ysz 111 1 Chloroquine Chloroquine NNP cord-297652-ut6e1ysz 111 2 ( ( -LRB- cord-297652-ut6e1ysz 111 3 Aralen Aralen NNP cord-297652-ut6e1ysz 111 4 ® ® NNP cord-297652-ut6e1ysz 111 5 ) ) -RRB- cord-297652-ut6e1ysz 111 6 is be VBZ cord-297652-ut6e1ysz 111 7 indicated indicate VBN cord-297652-ut6e1ysz 111 8 for for IN cord-297652-ut6e1ysz 111 9 the the DT cord-297652-ut6e1ysz 111 10 treatment treatment NN cord-297652-ut6e1ysz 111 11 of of IN cord-297652-ut6e1ysz 111 12 malaria malaria NN cord-297652-ut6e1ysz 111 13 and and CC cord-297652-ut6e1ysz 111 14 extraintestinal extraintestinal NNP cord-297652-ut6e1ysz 111 15 amebiasis amebiasis NNP cord-297652-ut6e1ysz 111 16 . . . cord-297652-ut6e1ysz 112 1 Hydroxychloroquine Hydroxychloroquine NNP cord-297652-ut6e1ysz 113 1 ( ( -LRB- cord-297652-ut6e1ysz 113 2 Plaquenil Plaquenil NNP cord-297652-ut6e1ysz 113 3 ® ® . cord-297652-ut6e1ysz 113 4 ) ) -RRB- cord-297652-ut6e1ysz 113 5 is be VBZ cord-297652-ut6e1ysz 113 6 also also RB cord-297652-ut6e1ysz 113 7 prescribed prescribe VBN cord-297652-ut6e1ysz 113 8 for for IN cord-297652-ut6e1ysz 113 9 the the DT cord-297652-ut6e1ysz 113 10 treatment treatment NN cord-297652-ut6e1ysz 113 11 of of IN cord-297652-ut6e1ysz 113 12 malaria malaria NN cord-297652-ut6e1ysz 113 13 . . . cord-297652-ut6e1ysz 114 1 It -PRON- PRP cord-297652-ut6e1ysz 114 2 is be VBZ cord-297652-ut6e1ysz 114 3 also also RB cord-297652-ut6e1ysz 114 4 used use VBN cord-297652-ut6e1ysz 114 5 successfully successfully RB cord-297652-ut6e1ysz 114 6 to to TO cord-297652-ut6e1ysz 114 7 treat treat VB cord-297652-ut6e1ysz 114 8 lupus lupus NN cord-297652-ut6e1ysz 114 9 erythematosus erythematosus NN cord-297652-ut6e1ysz 114 10 and and CC cord-297652-ut6e1ysz 114 11 rheumatoid rheumatoid NN cord-297652-ut6e1ysz 114 12 arthritis arthritis NN cord-297652-ut6e1ysz 114 13 [ [ -LRB- cord-297652-ut6e1ysz 114 14 27 27 CD cord-297652-ut6e1ysz 114 15 ] ] -RRB- cord-297652-ut6e1ysz 114 16 . . . cord-297652-ut6e1ysz 115 1 In in IN cord-297652-ut6e1ysz 115 2 addition addition NN cord-297652-ut6e1ysz 115 3 , , , cord-297652-ut6e1ysz 115 4 it -PRON- PRP cord-297652-ut6e1ysz 115 5 should should MD cord-297652-ut6e1ysz 115 6 be be VB cord-297652-ut6e1ysz 115 7 noted note VBN cord-297652-ut6e1ysz 115 8 that that IN cord-297652-ut6e1ysz 115 9 chloroquine chloroquine NN cord-297652-ut6e1ysz 115 10 , , , cord-297652-ut6e1ysz 115 11 essentially essentially RB cord-297652-ut6e1ysz 115 12 , , , cord-297652-ut6e1ysz 115 13 and and CC cord-297652-ut6e1ysz 115 14 hydroxychloroquine hydroxychloroquine UH cord-297652-ut6e1ysz 115 15 , , , cord-297652-ut6e1ysz 115 16 to to IN cord-297652-ut6e1ysz 115 17 a a DT cord-297652-ut6e1ysz 115 18 lesser less JJR cord-297652-ut6e1ysz 115 19 extent extent NN cord-297652-ut6e1ysz 115 20 , , , cord-297652-ut6e1ysz 115 21 have have VBP cord-297652-ut6e1ysz 115 22 been be VBN cord-297652-ut6e1ysz 115 23 clinically clinically RB cord-297652-ut6e1ysz 115 24 tested test VBN cord-297652-ut6e1ysz 115 25 for for IN cord-297652-ut6e1ysz 115 26 their -PRON- PRP$ cord-297652-ut6e1ysz 115 27 anti anti JJ cord-297652-ut6e1ysz 115 28 - - JJ cord-297652-ut6e1ysz 115 29 HIV hiv JJ cord-297652-ut6e1ysz 115 30 activity activity NN cord-297652-ut6e1ysz 115 31 [ [ -LRB- cord-297652-ut6e1ysz 115 32 4 4 CD cord-297652-ut6e1ysz 115 33 , , , cord-297652-ut6e1ysz 115 34 31 31 CD cord-297652-ut6e1ysz 115 35 ] ] -RRB- cord-297652-ut6e1ysz 115 36 . . . cord-297652-ut6e1ysz 116 1 As as RB cord-297652-ut6e1ysz 116 2 recently recently RB cord-297652-ut6e1ysz 116 3 as as IN cord-297652-ut6e1ysz 116 4 2006 2006 CD cord-297652-ut6e1ysz 116 5 , , , cord-297652-ut6e1ysz 116 6 the the DT cord-297652-ut6e1ysz 116 7 anti anti JJ cord-297652-ut6e1ysz 116 8 - - JJ cord-297652-ut6e1ysz 116 9 coronavirus coronavirus JJ cord-297652-ut6e1ysz 116 10 properties property NNS cord-297652-ut6e1ysz 116 11 of of IN cord-297652-ut6e1ysz 116 12 hydroxychloroquine hydroxychloroquine NN cord-297652-ut6e1ysz 116 13 and and CC cord-297652-ut6e1ysz 116 14 chloroquine chloroquine NNP cord-297652-ut6e1ysz 116 15 were be VBD cord-297652-ut6e1ysz 116 16 reported report VBN cord-297652-ut6e1ysz 116 17 by by IN cord-297652-ut6e1ysz 116 18 Biot Biot NNP cord-297652-ut6e1ysz 116 19 et et NNP cord-297652-ut6e1ysz 116 20 al al NNP cord-297652-ut6e1ysz 116 21 . . . cord-297652-ut6e1ysz 117 1 [ [ -LRB- cord-297652-ut6e1ysz 117 2 32 32 CD cord-297652-ut6e1ysz 117 3 ] ] -RRB- cord-297652-ut6e1ysz 117 4 . . . cord-297652-ut6e1ysz 118 1 Those those DT cord-297652-ut6e1ysz 118 2 authors author NNS cord-297652-ut6e1ysz 118 3 observed observe VBD cord-297652-ut6e1ysz 118 4 that that IN cord-297652-ut6e1ysz 118 5 , , , cord-297652-ut6e1ysz 118 6 in in IN cord-297652-ut6e1ysz 118 7 vitro vitro FW cord-297652-ut6e1ysz 118 8 , , , cord-297652-ut6e1ysz 118 9 both both DT cord-297652-ut6e1ysz 118 10 molecules molecule NNS cord-297652-ut6e1ysz 118 11 were be VBD cord-297652-ut6e1ysz 118 12 active active JJ cord-297652-ut6e1ysz 118 13 against against IN cord-297652-ut6e1ysz 118 14 SARS SARS NNP cord-297652-ut6e1ysz 118 15 - - HYPH cord-297652-ut6e1ysz 118 16 CoV CoV NNP cord-297652-ut6e1ysz 118 17 with with IN cord-297652-ut6e1ysz 118 18 EC EC NNP cord-297652-ut6e1ysz 118 19 50 50 CD cord-297652-ut6e1ysz 118 20 values value NNS cord-297652-ut6e1ysz 118 21 of of IN cord-297652-ut6e1ysz 118 22 34 34 CD cord-297652-ut6e1ysz 118 23 and and CC cord-297652-ut6e1ysz 118 24 6.5 6.5 CD cord-297652-ut6e1ysz 118 25 µM µm XX cord-297652-ut6e1ysz 118 26 , , , cord-297652-ut6e1ysz 118 27 for for IN cord-297652-ut6e1ysz 118 28 hydroxyquinoline hydroxyquinoline NNP cord-297652-ut6e1ysz 118 29 ( ( -LRB- cord-297652-ut6e1ysz 118 30 4 4 CD cord-297652-ut6e1ysz 118 31 ) ) -RRB- cord-297652-ut6e1ysz 118 32 and and CC cord-297652-ut6e1ysz 118 33 chloroquine chloroquine NNP cord-297652-ut6e1ysz 118 34 ( ( -LRB- cord-297652-ut6e1ysz 118 35 5 5 CD cord-297652-ut6e1ysz 118 36 ) ) -RRB- cord-297652-ut6e1ysz 118 37 , , , cord-297652-ut6e1ysz 118 38 respectively respectively RB cord-297652-ut6e1ysz 118 39 . . . cord-297652-ut6e1ysz 119 1 The the DT cord-297652-ut6e1ysz 119 2 difference difference NN cord-297652-ut6e1ysz 119 3 is be VBZ cord-297652-ut6e1ysz 119 4 less less RBR cord-297652-ut6e1ysz 119 5 marked mark VBN cord-297652-ut6e1ysz 119 6 in in IN cord-297652-ut6e1ysz 119 7 the the DT cord-297652-ut6e1ysz 119 8 study study NN cord-297652-ut6e1ysz 119 9 of of IN cord-297652-ut6e1ysz 119 10 Dyall Dyall NNP cord-297652-ut6e1ysz 119 11 et et FW cord-297652-ut6e1ysz 119 12 al al NNP cord-297652-ut6e1ysz 119 13 . . . cord-297652-ut6e1ysz 120 1 [ [ -LRB- cord-297652-ut6e1ysz 120 2 33 33 CD cord-297652-ut6e1ysz 120 3 ] ] -RRB- cord-297652-ut6e1ysz 120 4 who who WP cord-297652-ut6e1ysz 120 5 reported report VBD cord-297652-ut6e1ysz 120 6 EC EC NNP cord-297652-ut6e1ysz 120 7 50 50 CD cord-297652-ut6e1ysz 120 8 values value NNS cord-297652-ut6e1ysz 120 9 of of IN cord-297652-ut6e1ysz 120 10 7.97 7.97 CD cord-297652-ut6e1ysz 120 11 µM µm XX cord-297652-ut6e1ysz 120 12 ( ( -LRB- cord-297652-ut6e1ysz 120 13 4 4 CD cord-297652-ut6e1ysz 120 14 ) ) -RRB- cord-297652-ut6e1ysz 120 15 and and CC cord-297652-ut6e1ysz 120 16 6.54 6.54 CD cord-297652-ut6e1ysz 120 17 µM µm XX cord-297652-ut6e1ysz 120 18 ( ( -LRB- cord-297652-ut6e1ysz 120 19 5 5 CD cord-297652-ut6e1ysz 120 20 ) ) -RRB- cord-297652-ut6e1ysz 120 21 against against IN cord-297652-ut6e1ysz 120 22 SARS SARS NNP cord-297652-ut6e1ysz 120 23 - - HYPH cord-297652-ut6e1ysz 120 24 CoV CoV NNP cord-297652-ut6e1ysz 120 25 and and CC cord-297652-ut6e1ysz 120 26 8.28 8.28 CD cord-297652-ut6e1ysz 120 27 µM µm NN cord-297652-ut6e1ysz 120 28 ( ( -LRB- cord-297652-ut6e1ysz 120 29 4 4 CD cord-297652-ut6e1ysz 120 30 ) ) -RRB- cord-297652-ut6e1ysz 120 31 and and CC cord-297652-ut6e1ysz 120 32 6.28 6.28 CD cord-297652-ut6e1ysz 120 33 µM µm NN cord-297652-ut6e1ysz 120 34 ( ( -LRB- cord-297652-ut6e1ysz 120 35 5 5 CD cord-297652-ut6e1ysz 120 36 ) ) -RRB- cord-297652-ut6e1ysz 120 37 against against IN cord-297652-ut6e1ysz 120 38 MERS- MERS- NNP cord-297652-ut6e1ysz 121 1 CoV. CoV. NNP cord-297652-ut6e1ysz 122 1 The the DT cord-297652-ut6e1ysz 122 2 trend trend NN cord-297652-ut6e1ysz 122 3 is be VBZ cord-297652-ut6e1ysz 122 4 reversed reverse VBN cord-297652-ut6e1ysz 122 5 when when WRB cord-297652-ut6e1ysz 122 6 dealing deal VBG cord-297652-ut6e1ysz 122 7 with with IN cord-297652-ut6e1ysz 122 8 SARS SARS NNP cord-297652-ut6e1ysz 122 9 - - HYPH cord-297652-ut6e1ysz 122 10 CoV-2 CoV-2 NNP cord-297652-ut6e1ysz 122 11 , , , cord-297652-ut6e1ysz 122 12 as as IN cord-297652-ut6e1ysz 122 13 values value NNS cord-297652-ut6e1ysz 122 14 related relate VBN cord-297652-ut6e1ysz 122 15 by by IN cord-297652-ut6e1ysz 122 16 Yao Yao NNP cord-297652-ut6e1ysz 122 17 et et FW cord-297652-ut6e1ysz 122 18 al al NNP cord-297652-ut6e1ysz 122 19 . . . cord-297652-ut6e1ysz 123 1 [ [ -LRB- cord-297652-ut6e1ysz 123 2 34 34 CD cord-297652-ut6e1ysz 123 3 ] ] -RRB- cord-297652-ut6e1ysz 123 4 were be VBD cord-297652-ut6e1ysz 123 5 0.72 0.72 CD cord-297652-ut6e1ysz 123 6 µM µm NN cord-297652-ut6e1ysz 123 7 ( ( -LRB- cord-297652-ut6e1ysz 123 8 4 4 CD cord-297652-ut6e1ysz 123 9 ) ) -RRB- cord-297652-ut6e1ysz 123 10 and and CC cord-297652-ut6e1ysz 123 11 5.47 5.47 CD cord-297652-ut6e1ysz 123 12 µM µm NN cord-297652-ut6e1ysz 123 13 ( ( -LRB- cord-297652-ut6e1ysz 123 14 5 5 CD cord-297652-ut6e1ysz 123 15 ) ) -RRB- cord-297652-ut6e1ysz 123 16 . . . cord-297652-ut6e1ysz 124 1 A a DT cord-297652-ut6e1ysz 124 2 comparable comparable JJ cord-297652-ut6e1ysz 124 3 efficacy efficacy NN cord-297652-ut6e1ysz 124 4 of of IN cord-297652-ut6e1ysz 124 5 6.9 6.9 CD cord-297652-ut6e1ysz 124 6 µM µm NN cord-297652-ut6e1ysz 124 7 was be VBD cord-297652-ut6e1ysz 124 8 measured measure VBN cord-297652-ut6e1ysz 124 9 by by IN cord-297652-ut6e1ysz 124 10 Wang Wang NNP cord-297652-ut6e1ysz 124 11 et et NNP cord-297652-ut6e1ysz 124 12 al al NNP cord-297652-ut6e1ysz 124 13 . . . cord-297652-ut6e1ysz 125 1 [ [ -LRB- cord-297652-ut6e1ysz 125 2 11 11 CD cord-297652-ut6e1ysz 125 3 ] ] -RRB- cord-297652-ut6e1ysz 125 4 for for IN cord-297652-ut6e1ysz 125 5 chloroquine chloroquine NN cord-297652-ut6e1ysz 125 6 ( ( -LRB- cord-297652-ut6e1ysz 125 7 5 5 CD cord-297652-ut6e1ysz 125 8 ) ) -RRB- cord-297652-ut6e1ysz 125 9 . . . cord-297652-ut6e1ysz 126 1 On on IN cord-297652-ut6e1ysz 126 2 February February NNP cord-297652-ut6e1ysz 126 3 19 19 CD cord-297652-ut6e1ysz 126 4 , , , cord-297652-ut6e1ysz 126 5 Gao Gao NNP cord-297652-ut6e1ysz 126 6 et et NNP cord-297652-ut6e1ysz 126 7 al al NNP cord-297652-ut6e1ysz 126 8 . . . cord-297652-ut6e1ysz 127 1 [ [ -LRB- cord-297652-ut6e1ysz 127 2 35 35 CD cord-297652-ut6e1ysz 127 3 ] ] -RRB- cord-297652-ut6e1ysz 127 4 recorded record VBN cord-297652-ut6e1ysz 127 5 , , , cord-297652-ut6e1ysz 127 6 in in IN cord-297652-ut6e1ysz 127 7 China China NNP cord-297652-ut6e1ysz 127 8 , , , cord-297652-ut6e1ysz 127 9 15 15 CD cord-297652-ut6e1ysz 127 10 clinical clinical JJ cord-297652-ut6e1ysz 127 11 trials trial NNS cord-297652-ut6e1ysz 127 12 involving involve VBG cord-297652-ut6e1ysz 127 13 chloroquine chloroquine NN cord-297652-ut6e1ysz 127 14 . . . cord-297652-ut6e1ysz 128 1 On on IN cord-297652-ut6e1ysz 128 2 March March NNP cord-297652-ut6e1ysz 128 3 28 28 CD cord-297652-ut6e1ysz 128 4 , , , cord-297652-ut6e1ysz 128 5 the the DT cord-297652-ut6e1ysz 128 6 FDA FDA NNP cord-297652-ut6e1ysz 128 7 issued issue VBD cord-297652-ut6e1ysz 128 8 an an DT cord-297652-ut6e1ysz 128 9 Emergency Emergency NNP cord-297652-ut6e1ysz 128 10 Use Use NNP cord-297652-ut6e1ysz 128 11 Authorization Authorization NNP cord-297652-ut6e1ysz 128 12 for for IN cord-297652-ut6e1ysz 128 13 use use NN cord-297652-ut6e1ysz 128 14 of of IN cord-297652-ut6e1ysz 128 15 hydroxychloroquine hydroxychloroquine NN cord-297652-ut6e1ysz 128 16 and and CC cord-297652-ut6e1ysz 128 17 chloroquine chloroquine NN cord-297652-ut6e1ysz 128 18 for for IN cord-297652-ut6e1ysz 128 19 patients patient NNS cord-297652-ut6e1ysz 128 20 who who WP cord-297652-ut6e1ysz 128 21 do do VBP cord-297652-ut6e1ysz 128 22 not not RB cord-297652-ut6e1ysz 128 23 have have VB cord-297652-ut6e1ysz 128 24 access access NN cord-297652-ut6e1ysz 128 25 to to IN cord-297652-ut6e1ysz 128 26 the the DT cord-297652-ut6e1ysz 128 27 drugs drug NNS cord-297652-ut6e1ysz 128 28 via via IN cord-297652-ut6e1ysz 128 29 clinical clinical JJ cord-297652-ut6e1ysz 128 30 trials trial NNS cord-297652-ut6e1ysz 128 31 [ [ -LRB- cord-297652-ut6e1ysz 128 32 36 36 CD cord-297652-ut6e1ysz 128 33 ] ] -RRB- cord-297652-ut6e1ysz 128 34 . . . cord-297652-ut6e1ysz 129 1 As as IN cord-297652-ut6e1ysz 129 2 underlined underline VBN cord-297652-ut6e1ysz 129 3 by by IN cord-297652-ut6e1ysz 129 4 a a DT cord-297652-ut6e1ysz 129 5 reviewer reviewer NN cord-297652-ut6e1ysz 129 6 of of IN cord-297652-ut6e1ysz 129 7 this this DT cord-297652-ut6e1ysz 129 8 manuscript manuscript NN cord-297652-ut6e1ysz 129 9 , , , cord-297652-ut6e1ysz 129 10 this this DT cord-297652-ut6e1ysz 129 11 essentially essentially RB cord-297652-ut6e1ysz 129 12 means mean VBZ cord-297652-ut6e1ysz 129 13 that that IN cord-297652-ut6e1ysz 129 14 lots lot NNS cord-297652-ut6e1ysz 129 15 of of IN cord-297652-ut6e1ysz 129 16 anecdotal anecdotal JJ cord-297652-ut6e1ysz 129 17 testimonies testimony NNS cord-297652-ut6e1ysz 129 18 as as IN cord-297652-ut6e1ysz 129 19 to to IN cord-297652-ut6e1ysz 129 20 the the DT cord-297652-ut6e1ysz 129 21 effects effect NNS cord-297652-ut6e1ysz 129 22 of of IN cord-297652-ut6e1ysz 129 23 these these DT cord-297652-ut6e1ysz 129 24 two two CD cord-297652-ut6e1ysz 129 25 drugs drug NNS cord-297652-ut6e1ysz 129 26 will will MD cord-297652-ut6e1ysz 129 27 be be VB cord-297652-ut6e1ysz 129 28 released release VBN cord-297652-ut6e1ysz 129 29 until until IN cord-297652-ut6e1ysz 129 30 properly properly RB cord-297652-ut6e1ysz 129 31 controlled control VBN cord-297652-ut6e1ysz 129 32 clinical clinical JJ cord-297652-ut6e1ysz 129 33 trials trial NNS cord-297652-ut6e1ysz 129 34 are be VBP cord-297652-ut6e1ysz 129 35 done do VBN cord-297652-ut6e1ysz 129 36 . . . cord-297652-ut6e1ysz 130 1 As as IN cord-297652-ut6e1ysz 130 2 of of IN cord-297652-ut6e1ysz 130 3 8 8 CD cord-297652-ut6e1ysz 130 4 April April NNP cord-297652-ut6e1ysz 130 5 , , , cord-297652-ut6e1ysz 130 6 58 58 CD cord-297652-ut6e1ysz 130 7 clinical clinical JJ cord-297652-ut6e1ysz 130 8 trials trial NNS cord-297652-ut6e1ysz 130 9 concern concern NN cord-297652-ut6e1ysz 130 10 hydroxychloroquine hydroxychloroquine NN cord-297652-ut6e1ysz 130 11 , , , cord-297652-ut6e1ysz 130 12 compared compare VBN cord-297652-ut6e1ysz 130 13 to to IN cord-297652-ut6e1ysz 130 14 19 19 CD cord-297652-ut6e1ysz 130 15 on on IN cord-297652-ut6e1ysz 130 16 March March NNP cord-297652-ut6e1ysz 130 17 28 28 CD cord-297652-ut6e1ysz 130 18 [ [ -LRB- cord-297652-ut6e1ysz 130 19 4 4 CD cord-297652-ut6e1ysz 130 20 ] ] -RRB- cord-297652-ut6e1ysz 130 21 . . . cord-297652-ut6e1ysz 131 1 In in IN cord-297652-ut6e1ysz 131 2 France France NNP cord-297652-ut6e1ysz 131 3 , , , cord-297652-ut6e1ysz 131 4 controversial controversial JJ cord-297652-ut6e1ysz 131 5 results result NNS cord-297652-ut6e1ysz 131 6 have have VBP cord-297652-ut6e1ysz 131 7 been be VBN cord-297652-ut6e1ysz 131 8 published publish VBN cord-297652-ut6e1ysz 131 9 , , , cord-297652-ut6e1ysz 131 10 in in IN cord-297652-ut6e1ysz 131 11 March March NNP cord-297652-ut6e1ysz 131 12 , , , cord-297652-ut6e1ysz 131 13 on on IN cord-297652-ut6e1ysz 131 14 a a DT cord-297652-ut6e1ysz 131 15 treatment treatment NN cord-297652-ut6e1ysz 131 16 associating associate VBG cord-297652-ut6e1ysz 131 17 the the DT cord-297652-ut6e1ysz 131 18 same same JJ cord-297652-ut6e1ysz 131 19 dosing dosing NN cord-297652-ut6e1ysz 131 20 regimen regimen NN cord-297652-ut6e1ysz 131 21 of of IN cord-297652-ut6e1ysz 131 22 hydroxychloroquine hydroxychloroquine NN cord-297652-ut6e1ysz 131 23 and and CC cord-297652-ut6e1ysz 131 24 azithromycin azithromycin NNP cord-297652-ut6e1ysz 131 25 . . . cord-297652-ut6e1ysz 132 1 The the DT cord-297652-ut6e1ysz 132 2 treatment treatment NN cord-297652-ut6e1ysz 132 3 was be VBD cord-297652-ut6e1ysz 132 4 administered administer VBN cord-297652-ut6e1ysz 132 5 to to IN cord-297652-ut6e1ysz 132 6 small small JJ cord-297652-ut6e1ysz 132 7 cohorts cohort NNS cord-297652-ut6e1ysz 132 8 ( ( -LRB- cord-297652-ut6e1ysz 132 9 less less JJR cord-297652-ut6e1ysz 132 10 than than IN cord-297652-ut6e1ysz 132 11 25 25 CD cord-297652-ut6e1ysz 132 12 people people NNS cord-297652-ut6e1ysz 132 13 ) ) -RRB- cord-297652-ut6e1ysz 132 14 of of IN cord-297652-ut6e1ysz 132 15 patients patient NNS cord-297652-ut6e1ysz 132 16 hospitalized hospitalize VBN cord-297652-ut6e1ysz 132 17 for for IN cord-297652-ut6e1ysz 132 18 severe severe JJ cord-297652-ut6e1ysz 132 19 COVID-19 covid-19 CD cord-297652-ut6e1ysz 132 20 infection infection NN cord-297652-ut6e1ysz 132 21 [ [ -LRB- cord-297652-ut6e1ysz 132 22 37 37 CD cord-297652-ut6e1ysz 132 23 , , , cord-297652-ut6e1ysz 132 24 38 38 CD cord-297652-ut6e1ysz 132 25 ] ] -RRB- cord-297652-ut6e1ysz 132 26 . . . cord-297652-ut6e1ysz 133 1 Due due IN cord-297652-ut6e1ysz 133 2 to to IN cord-297652-ut6e1ysz 133 3 such such JJ cord-297652-ut6e1ysz 133 4 confusion confusion NN cord-297652-ut6e1ysz 133 5 , , , cord-297652-ut6e1ysz 133 6 in in IN cord-297652-ut6e1ysz 133 7 France France NNP cord-297652-ut6e1ysz 133 8 and and CC cord-297652-ut6e1ysz 133 9 Belgium Belgium NNP cord-297652-ut6e1ysz 133 10 ( ( -LRB- cord-297652-ut6e1ysz 133 11 and and CC cord-297652-ut6e1ysz 133 12 probably probably RB cord-297652-ut6e1ysz 133 13 in in IN cord-297652-ut6e1ysz 133 14 other other JJ cord-297652-ut6e1ysz 133 15 countries country NNS cord-297652-ut6e1ysz 133 16 ) ) -RRB- cord-297652-ut6e1ysz 133 17 , , , cord-297652-ut6e1ysz 133 18 politicians politician NNS cord-297652-ut6e1ysz 133 19 , , , cord-297652-ut6e1ysz 133 20 their -PRON- PRP$ cord-297652-ut6e1ysz 133 21 advisors advisor NNS cord-297652-ut6e1ysz 133 22 , , , cord-297652-ut6e1ysz 133 23 and and CC cord-297652-ut6e1ysz 133 24 even even RB cord-297652-ut6e1ysz 133 25 some some DT cord-297652-ut6e1ysz 133 26 physicians physician NNS cord-297652-ut6e1ysz 133 27 called call VBD cord-297652-ut6e1ysz 133 28 for for IN cord-297652-ut6e1ysz 133 29 caution caution NN cord-297652-ut6e1ysz 133 30 . . . cord-297652-ut6e1ysz 134 1 They -PRON- PRP cord-297652-ut6e1ysz 134 2 suggested suggest VBD cord-297652-ut6e1ysz 134 3 that that IN cord-297652-ut6e1ysz 134 4 preliminary preliminary JJ cord-297652-ut6e1ysz 134 5 reports report NNS cord-297652-ut6e1ysz 134 6 describing describe VBG cord-297652-ut6e1ysz 134 7 successful successful JJ cord-297652-ut6e1ysz 134 8 outcomes outcome NNS cord-297652-ut6e1ysz 134 9 in in IN cord-297652-ut6e1ysz 134 10 the the DT cord-297652-ut6e1ysz 134 11 use use NN cord-297652-ut6e1ysz 134 12 of of IN cord-297652-ut6e1ysz 134 13 hydroxychloroquine hydroxychloroquine NN cord-297652-ut6e1ysz 134 14 or or CC cord-297652-ut6e1ysz 134 15 chloroquine chloroquine NN cord-297652-ut6e1ysz 134 16 in in IN cord-297652-ut6e1ysz 134 17 hospitals hospital NNS cord-297652-ut6e1ysz 134 18 must must MD cord-297652-ut6e1ysz 134 19 be be VB cord-297652-ut6e1ysz 134 20 carefully carefully RB cord-297652-ut6e1ysz 134 21 considered consider VBN cord-297652-ut6e1ysz 134 22 , , , cord-297652-ut6e1ysz 134 23 either either CC cord-297652-ut6e1ysz 134 24 because because IN cord-297652-ut6e1ysz 134 25 those those DT cord-297652-ut6e1ysz 134 26 two two CD cord-297652-ut6e1ysz 134 27 molecules molecule NNS cord-297652-ut6e1ysz 134 28 are be VBP cord-297652-ut6e1ysz 134 29 plagued plague VBN cord-297652-ut6e1ysz 134 30 by by IN cord-297652-ut6e1ysz 134 31 side side NN cord-297652-ut6e1ysz 134 32 - - HYPH cord-297652-ut6e1ysz 134 33 effects effect NNS cord-297652-ut6e1ysz 134 34 or or CC cord-297652-ut6e1ysz 134 35 because because IN cord-297652-ut6e1ysz 134 36 of of IN cord-297652-ut6e1ysz 134 37 a a DT cord-297652-ut6e1ysz 134 38 lack lack NN cord-297652-ut6e1ysz 134 39 of of IN cord-297652-ut6e1ysz 134 40 scientific scientific JJ cord-297652-ut6e1ysz 134 41 rigor rigor NN cord-297652-ut6e1ysz 134 42 in in IN cord-297652-ut6e1ysz 134 43 the the DT cord-297652-ut6e1ysz 134 44 studies study NNS cord-297652-ut6e1ysz 134 45 . . . cord-297652-ut6e1ysz 135 1 Contrastingly contrastingly RB cord-297652-ut6e1ysz 135 2 , , , cord-297652-ut6e1ysz 135 3 The the DT cord-297652-ut6e1ysz 135 4 Bill Bill NNP cord-297652-ut6e1ysz 135 5 and and CC cord-297652-ut6e1ysz 135 6 Melinda Melinda NNP cord-297652-ut6e1ysz 135 7 Gates Gates NNP cord-297652-ut6e1ysz 135 8 foundation foundation NN cord-297652-ut6e1ysz 135 9 announced announce VBD cord-297652-ut6e1ysz 135 10 that that IN cord-297652-ut6e1ysz 135 11 it -PRON- PRP cord-297652-ut6e1ysz 135 12 had have VBD cord-297652-ut6e1ysz 135 13 launched launch VBN cord-297652-ut6e1ysz 135 14 and and CC cord-297652-ut6e1ysz 135 15 financially financially RB cord-297652-ut6e1ysz 135 16 supported support VBD cord-297652-ut6e1ysz 135 17 two two CD cord-297652-ut6e1ysz 135 18 trials trial NNS cord-297652-ut6e1ysz 135 19 aiming aim VBG cord-297652-ut6e1ysz 135 20 at at IN cord-297652-ut6e1ysz 135 21 a a DT cord-297652-ut6e1ysz 135 22 study study NN cord-297652-ut6e1ysz 135 23 on on IN cord-297652-ut6e1ysz 135 24 the the DT cord-297652-ut6e1ysz 135 25 use use NN cord-297652-ut6e1ysz 135 26 of of IN cord-297652-ut6e1ysz 135 27 hydroxychloroquine hydroxychloroquine NN cord-297652-ut6e1ysz 135 28 as as IN cord-297652-ut6e1ysz 135 29 a a DT cord-297652-ut6e1ysz 135 30 prophylactic prophylactic JJ cord-297652-ut6e1ysz 135 31 agent agent NN cord-297652-ut6e1ysz 135 32 for for IN cord-297652-ut6e1ysz 135 33 COVID-19 COVID-19 NNP cord-297652-ut6e1ysz 135 34 [ [ -LRB- cord-297652-ut6e1ysz 135 35 39 39 CD cord-297652-ut6e1ysz 135 36 ] ] -RRB- cord-297652-ut6e1ysz 135 37 . . . cord-297652-ut6e1ysz 136 1 In in IN cord-297652-ut6e1ysz 136 2 the the DT cord-297652-ut6e1ysz 136 3 Discovery Discovery NNP cord-297652-ut6e1ysz 136 4 project project NN cord-297652-ut6e1ysz 136 5 , , , cord-297652-ut6e1ysz 136 6 the the DT cord-297652-ut6e1ysz 136 7 suggested suggest VBN cord-297652-ut6e1ysz 136 8 dosage dosage NN cord-297652-ut6e1ysz 136 9 for for IN cord-297652-ut6e1ysz 136 10 hydroxychloroquine hydroxychloroquine NNP cord-297652-ut6e1ysz 136 11 is be VBZ cord-297652-ut6e1ysz 136 12 400 400 CD cord-297652-ut6e1ysz 136 13 mg mg NN cord-297652-ut6e1ysz 136 14 for for IN cord-297652-ut6e1ysz 136 15 the the DT cord-297652-ut6e1ysz 136 16 initial initial JJ cord-297652-ut6e1ysz 136 17 dose dose NN cord-297652-ut6e1ysz 136 18 , , , cord-297652-ut6e1ysz 136 19 followed follow VBN cord-297652-ut6e1ysz 136 20 by by IN cord-297652-ut6e1ysz 136 21 400 400 CD cord-297652-ut6e1ysz 136 22 mg mg NN cord-297652-ut6e1ysz 136 23 12 12 CD cord-297652-ut6e1ysz 136 24 h h NNP cord-297652-ut6e1ysz 136 25 later later RB cord-297652-ut6e1ysz 137 1 and and CC cord-297652-ut6e1ysz 137 2 then then RB cord-297652-ut6e1ysz 137 3 200 200 CD cord-297652-ut6e1ysz 137 4 mg mg NN cord-297652-ut6e1ysz 137 5 BID BID VBN cord-297652-ut6e1ysz 137 6 for for IN cord-297652-ut6e1ysz 137 7 up up IN cord-297652-ut6e1ysz 137 8 to to TO cord-297652-ut6e1ysz 137 9 4 4 CD cord-297652-ut6e1ysz 137 10 days day NNS cord-297652-ut6e1ysz 137 11 . . . cord-297652-ut6e1ysz 138 1 Using use VBG cord-297652-ut6e1ysz 138 2 the the DT cord-297652-ut6e1ysz 138 3 same same JJ cord-297652-ut6e1ysz 138 4 metric metric NN cord-297652-ut6e1ysz 138 5 [ [ -LRB- cord-297652-ut6e1ysz 138 6 23 23 CD cord-297652-ut6e1ysz 138 7 ] ] -RRB- cord-297652-ut6e1ysz 138 8 to to TO cord-297652-ut6e1ysz 138 9 evaluate evaluate VB cord-297652-ut6e1ysz 138 10 the the DT cord-297652-ut6e1ysz 138 11 cost cost NN cord-297652-ut6e1ysz 138 12 of of IN cord-297652-ut6e1ysz 138 13 the the DT cord-297652-ut6e1ysz 138 14 treatment treatment NN cord-297652-ut6e1ysz 138 15 , , , cord-297652-ut6e1ysz 138 16 the the DT cord-297652-ut6e1ysz 138 17 price price NN cord-297652-ut6e1ysz 138 18 should should MD cord-297652-ut6e1ysz 138 19 not not RB cord-297652-ut6e1ysz 138 20 exceed exceed VB cord-297652-ut6e1ysz 138 21 4.1 4.1 CD cord-297652-ut6e1ysz 138 22 USD usd NN cord-297652-ut6e1ysz 138 23 . . . cord-297652-ut6e1ysz 139 1 Alternatively alternatively RB cord-297652-ut6e1ysz 139 2 , , , cord-297652-ut6e1ysz 139 3 a a DT cord-297652-ut6e1ysz 139 4 higher high JJR cord-297652-ut6e1ysz 139 5 dosage dosage NN cord-297652-ut6e1ysz 139 6 is be VBZ cord-297652-ut6e1ysz 139 7 proposed propose VBN cord-297652-ut6e1ysz 139 8 for for IN cord-297652-ut6e1ysz 139 9 chloroquine chloroquine NN cord-297652-ut6e1ysz 139 10 : : : cord-297652-ut6e1ysz 139 11 600 600 CD cord-297652-ut6e1ysz 139 12 mg mg NN cord-297652-ut6e1ysz 139 13 for for IN cord-297652-ut6e1ysz 139 14 the the DT cord-297652-ut6e1ysz 139 15 initial initial JJ cord-297652-ut6e1ysz 139 16 dose dose NN cord-297652-ut6e1ysz 139 17 , , , cord-297652-ut6e1ysz 139 18 followed follow VBN cord-297652-ut6e1ysz 139 19 by by IN cord-297652-ut6e1ysz 139 20 600 600 CD cord-297652-ut6e1ysz 139 21 mg mg CD cord-297652-ut6e1ysz 139 22 12 12 CD cord-297652-ut6e1ysz 139 23 h h NNP cord-297652-ut6e1ysz 139 24 later later RB cord-297652-ut6e1ysz 140 1 and and CC cord-297652-ut6e1ysz 140 2 then then RB cord-297652-ut6e1ysz 140 3 300 300 CD cord-297652-ut6e1ysz 140 4 mg mg NN cord-297652-ut6e1ysz 140 5 BID BID VBD cord-297652-ut6e1ysz 140 6 for for IN cord-297652-ut6e1ysz 140 7 up up IN cord-297652-ut6e1ysz 140 8 to to TO cord-297652-ut6e1ysz 140 9 4 4 CD cord-297652-ut6e1ysz 140 10 days day NNS cord-297652-ut6e1ysz 140 11 . . . cord-297652-ut6e1ysz 141 1 Considering consider VBG cord-297652-ut6e1ysz 141 2 the the DT cord-297652-ut6e1ysz 141 3 commercial commercial JJ cord-297652-ut6e1ysz 141 4 availability availability NN cord-297652-ut6e1ysz 141 5 of of IN cord-297652-ut6e1ysz 141 6 chloroquine chloroquine NN cord-297652-ut6e1ysz 141 7 as as IN cord-297652-ut6e1ysz 141 8 a a DT cord-297652-ut6e1ysz 141 9 diphosphate diphosphate NN cord-297652-ut6e1ysz 141 10 salt salt NN cord-297652-ut6e1ysz 141 11 , , , cord-297652-ut6e1ysz 141 12 the the DT cord-297652-ut6e1ysz 141 13 retail retail JJ cord-297652-ut6e1ysz 141 14 price price NN cord-297652-ut6e1ysz 141 15 would would MD cord-297652-ut6e1ysz 141 16 not not RB cord-297652-ut6e1ysz 141 17 exceed exceed VB cord-297652-ut6e1ysz 141 18 6.6 6.6 CD cord-297652-ut6e1ysz 141 19 USD usd NN cord-297652-ut6e1ysz 141 20 [ [ -LRB- cord-297652-ut6e1ysz 141 21 23 23 CD cord-297652-ut6e1ysz 141 22 ] ] -RRB- cord-297652-ut6e1ysz 141 23 . . . cord-297652-ut6e1ysz 142 1 The the DT cord-297652-ut6e1ysz 142 2 first first JJ cord-297652-ut6e1ysz 142 3 cases case NNS cord-297652-ut6e1ysz 142 4 of of IN cord-297652-ut6e1ysz 142 5 COVID-19 COVID-19 NNP cord-297652-ut6e1ysz 142 6 emerged emerge VBD cord-297652-ut6e1ysz 142 7 in in IN cord-297652-ut6e1ysz 142 8 Wuhan Wuhan NNP cord-297652-ut6e1ysz 142 9 , , , cord-297652-ut6e1ysz 142 10 China China NNP cord-297652-ut6e1ysz 142 11 , , , cord-297652-ut6e1ysz 142 12 in in IN cord-297652-ut6e1ysz 142 13 late late JJ cord-297652-ut6e1ysz 142 14 2019 2019 CD cord-297652-ut6e1ysz 142 15 , , , cord-297652-ut6e1ysz 142 16 and and CC cord-297652-ut6e1ysz 142 17 to to IN cord-297652-ut6e1ysz 142 18 date date NN cord-297652-ut6e1ysz 142 19 there there EX cord-297652-ut6e1ysz 142 20 is be VBZ cord-297652-ut6e1ysz 142 21 no no DT cord-297652-ut6e1ysz 142 22 approved approve VBN cord-297652-ut6e1ysz 142 23 specific specific JJ cord-297652-ut6e1ysz 142 24 drug drug NN cord-297652-ut6e1ysz 142 25 to to TO cord-297652-ut6e1ysz 142 26 cure cure VB cord-297652-ut6e1ysz 142 27 patients patient NNS cord-297652-ut6e1ysz 142 28 infected infect VBN cord-297652-ut6e1ysz 142 29 by by IN cord-297652-ut6e1ysz 142 30 SARS SARS NNP cord-297652-ut6e1ysz 142 31 - - HYPH cord-297652-ut6e1ysz 142 32 CoV-2 CoV-2 NNP cord-297652-ut6e1ysz 142 33 . . . cord-297652-ut6e1ysz 143 1 Politicians politician NNS cord-297652-ut6e1ysz 143 2 and and CC cord-297652-ut6e1ysz 143 3 physicians physician NNS cord-297652-ut6e1ysz 143 4 suggest suggest VBP cord-297652-ut6e1ysz 143 5 that that IN cord-297652-ut6e1ysz 143 6 we -PRON- PRP cord-297652-ut6e1ysz 143 7 should should MD cord-297652-ut6e1ysz 143 8 wait wait VB cord-297652-ut6e1ysz 143 9 for for IN cord-297652-ut6e1ysz 143 10 clinical clinical JJ cord-297652-ut6e1ysz 143 11 trials trial NNS cord-297652-ut6e1ysz 143 12 ' ' POS cord-297652-ut6e1ysz 143 13 data datum NNS cord-297652-ut6e1ysz 143 14 before before IN cord-297652-ut6e1ysz 143 15 considering consider VBG cord-297652-ut6e1ysz 143 16 an an DT cord-297652-ut6e1ysz 143 17 eventual eventual JJ cord-297652-ut6e1ysz 143 18 treatment treatment NN cord-297652-ut6e1ysz 143 19 . . . cord-297652-ut6e1ysz 144 1 In in IN cord-297652-ut6e1ysz 144 2 Europe Europe NNP cord-297652-ut6e1ysz 144 3 , , , cord-297652-ut6e1ysz 144 4 the the DT cord-297652-ut6e1ysz 144 5 Discovery Discovery NNP cord-297652-ut6e1ysz 144 6 project project NN cord-297652-ut6e1ysz 144 7 ( ( -LRB- cord-297652-ut6e1ysz 144 8 NCT04315948 NCT04315948 NNP cord-297652-ut6e1ysz 144 9 ) ) -RRB- cord-297652-ut6e1ysz 144 10 has have VBZ cord-297652-ut6e1ysz 144 11 a a DT cord-297652-ut6e1ysz 144 12 study study NN cord-297652-ut6e1ysz 144 13 start start VB cord-297652-ut6e1ysz 144 14 date date NN cord-297652-ut6e1ysz 144 15 of of IN cord-297652-ut6e1ysz 144 16 March March NNP cord-297652-ut6e1ysz 144 17 22 22 CD cord-297652-ut6e1ysz 144 18 , , , cord-297652-ut6e1ysz 144 19 2020 2020 CD cord-297652-ut6e1ysz 144 20 and and CC cord-297652-ut6e1ysz 144 21 will will MD cord-297652-ut6e1ysz 144 22 enroll enroll VB cord-297652-ut6e1ysz 144 23 3100 3100 CD cord-297652-ut6e1ysz 144 24 patients patient NNS cord-297652-ut6e1ysz 144 25 . . . cord-297652-ut6e1ysz 145 1 The the DT cord-297652-ut6e1ysz 145 2 first first JJ cord-297652-ut6e1ysz 145 3 results result NNS cord-297652-ut6e1ysz 145 4 should should MD cord-297652-ut6e1ysz 145 5 be be VB cord-297652-ut6e1ysz 145 6 available available JJ cord-297652-ut6e1ysz 145 7 within within IN cord-297652-ut6e1ysz 145 8 time time NN cord-297652-ut6e1ysz 145 9 frames frame NNS cord-297652-ut6e1ysz 145 10 of of IN cord-297652-ut6e1ysz 145 11 15 15 CD cord-297652-ut6e1ysz 145 12 and and CC cord-297652-ut6e1ysz 145 13 29 29 CD cord-297652-ut6e1ysz 145 14 days day NNS cord-297652-ut6e1ysz 145 15 , , , cord-297652-ut6e1ysz 145 16 but but CC cord-297652-ut6e1ysz 145 17 no no DT cord-297652-ut6e1ysz 145 18 publication publication NN cord-297652-ut6e1ysz 145 19 date date NN cord-297652-ut6e1ysz 145 20 has have VBZ cord-297652-ut6e1ysz 145 21 been be VBN cord-297652-ut6e1ysz 145 22 announced announce VBN cord-297652-ut6e1ysz 145 23 . . . cord-297652-ut6e1ysz 146 1 The the DT cord-297652-ut6e1ysz 146 2 estimated estimated JJ cord-297652-ut6e1ysz 146 3 study study NN cord-297652-ut6e1ysz 146 4 completion completion NN cord-297652-ut6e1ysz 146 5 date date NN cord-297652-ut6e1ysz 146 6 has have VBZ cord-297652-ut6e1ysz 146 7 been be VBN cord-297652-ut6e1ysz 146 8 set set VBN cord-297652-ut6e1ysz 146 9 in in IN cord-297652-ut6e1ysz 146 10 March March NNP cord-297652-ut6e1ysz 146 11 2023 2023 CD cord-297652-ut6e1ysz 146 12 . . . cord-297652-ut6e1ysz 147 1 As as IN cord-297652-ut6e1ysz 147 2 of of IN cord-297652-ut6e1ysz 147 3 April April NNP cord-297652-ut6e1ysz 147 4 8 8 CD cord-297652-ut6e1ysz 147 5 , , , cord-297652-ut6e1ysz 147 6 there there EX cord-297652-ut6e1ysz 147 7 are be VBP cord-297652-ut6e1ysz 147 8 388 388 CD cord-297652-ut6e1ysz 147 9 ongoing ongoing JJ cord-297652-ut6e1ysz 147 10 studies study NNS cord-297652-ut6e1ysz 147 11 on on IN cord-297652-ut6e1ysz 147 12 COVID-19 COVID-19 NNP cord-297652-ut6e1ysz 147 13 that that WDT cord-297652-ut6e1ysz 147 14 are be VBP cord-297652-ut6e1ysz 147 15 recorded record VBN cord-297652-ut6e1ysz 147 16 in in IN cord-297652-ut6e1ysz 147 17 the the DT cord-297652-ut6e1ysz 147 18 U.S. U.S. NNP cord-297652-ut6e1ysz 147 19 National National NNP cord-297652-ut6e1ysz 147 20 Library Library NNP cord-297652-ut6e1ysz 147 21 of of IN cord-297652-ut6e1ysz 147 22 Medicine Medicine NNP cord-297652-ut6e1ysz 147 23 of of IN cord-297652-ut6e1ysz 147 24 the the DT cord-297652-ut6e1ysz 147 25 National National NNP cord-297652-ut6e1ysz 147 26 Institutes Institutes NNPS cord-297652-ut6e1ysz 147 27 of of IN cord-297652-ut6e1ysz 147 28 Health Health NNP cord-297652-ut6e1ysz 147 29 [ [ -LRB- cord-297652-ut6e1ysz 147 30 4 4 CD cord-297652-ut6e1ysz 147 31 ] ] -RRB- cord-297652-ut6e1ysz 147 32 : : : cord-297652-ut6e1ysz 147 33 a a DT cord-297652-ut6e1ysz 147 34 breath breath NN cord-297652-ut6e1ysz 147 35 of of IN cord-297652-ut6e1ysz 147 36 hope hope NN cord-297652-ut6e1ysz 147 37 . . . cord-297652-ut6e1ysz 148 1 A a DT cord-297652-ut6e1ysz 148 2 novel novel JJ cord-297652-ut6e1ysz 148 3 coronavirus coronavirus NN cord-297652-ut6e1ysz 148 4 from from IN cord-297652-ut6e1ysz 148 5 patients patient NNS cord-297652-ut6e1ysz 148 6 with with IN cord-297652-ut6e1ysz 148 7 pneumonia pneumonia NN cord-297652-ut6e1ysz 148 8 in in IN cord-297652-ut6e1ysz 148 9 China China NNP cord-297652-ut6e1ysz 149 1 The the DT cord-297652-ut6e1ysz 149 2 species specie NNS cord-297652-ut6e1ysz 149 3 Severe severe JJ cord-297652-ut6e1ysz 149 4 acute acute JJ cord-297652-ut6e1ysz 149 5 respiratory respiratory JJ cord-297652-ut6e1ysz 149 6 syndrome syndrome NN cord-297652-ut6e1ysz 149 7 related relate VBN cord-297652-ut6e1ysz 149 8 coronavirus coronavirus NN cord-297652-ut6e1ysz 149 9 : : : cord-297652-ut6e1ysz 149 10 Classifying classify VBG cord-297652-ut6e1ysz 149 11 2019-nCoV 2019-ncov CD cord-297652-ut6e1ysz 149 12 and and CC cord-297652-ut6e1ysz 149 13 naming name VBG cord-297652-ut6e1ysz 149 14 it -PRON- PRP cord-297652-ut6e1ysz 149 15 SARS SARS NNP cord-297652-ut6e1ysz 149 16 - - HYPH cord-297652-ut6e1ysz 149 17 CoV-2 CoV-2 NNP cord-297652-ut6e1ysz 150 1 A a DT cord-297652-ut6e1ysz 150 2 Call call NN cord-297652-ut6e1ysz 150 3 to to IN cord-297652-ut6e1ysz 150 4 Action action NN cord-297652-ut6e1ysz 150 5 : : : cord-297652-ut6e1ysz 151 1 Philanthropy Philanthropy NNP cord-297652-ut6e1ysz 151 2 's 's POS cord-297652-ut6e1ysz 151 3 Commitment Commitment NNP cord-297652-ut6e1ysz 151 4 during during IN cord-297652-ut6e1ysz 151 5 COVID-19 COVID-19 NNP cord-297652-ut6e1ysz 151 6 Foundation Foundation NNP cord-297652-ut6e1ysz 151 7 and and CC cord-297652-ut6e1ysz 151 8 Partners Partners NNPS cord-297652-ut6e1ysz 151 9 Launch launch VBP cord-297652-ut6e1ysz 152 1 First first JJ cord-297652-ut6e1ysz 152 2 - - HYPH cord-297652-ut6e1ysz 152 3 of of IN cord-297652-ut6e1ysz 152 4 - - HYPH cord-297652-ut6e1ysz 152 5 its -PRON- PRP$ cord-297652-ut6e1ysz 152 6 - - HYPH cord-297652-ut6e1ysz 152 7 kind kind NN cord-297652-ut6e1ysz 152 8 COVID-19 COVID-19 NNP cord-297652-ut6e1ysz 152 9 Solidarity Solidarity NNP cord-297652-ut6e1ysz 152 10 Response Response NNP cord-297652-ut6e1ysz 152 11 Fund Fund NNP cord-297652-ut6e1ysz 153 1 A a DT cord-297652-ut6e1ysz 153 2 randomized randomized JJ cord-297652-ut6e1ysz 153 3 , , , cord-297652-ut6e1ysz 153 4 controlled control VBN cord-297652-ut6e1ysz 153 5 trial trial NN cord-297652-ut6e1ysz 153 6 of of IN cord-297652-ut6e1ysz 153 7 Ebola Ebola NNP cord-297652-ut6e1ysz 153 8 virus virus NN cord-297652-ut6e1ysz 153 9 disease disease NN cord-297652-ut6e1ysz 153 10 therapeutics therapeutics NNP cord-297652-ut6e1ysz 153 11 Broad Broad NNP cord-297652-ut6e1ysz 153 12 - - HYPH cord-297652-ut6e1ysz 153 13 spectrum spectrum NN cord-297652-ut6e1ysz 153 14 antiviral antiviral JJ cord-297652-ut6e1ysz 153 15 GS-5734 GS-5734 NNS cord-297652-ut6e1ysz 153 16 inhibits inhibit VBZ cord-297652-ut6e1ysz 153 17 both both DT cord-297652-ut6e1ysz 153 18 epidemic epidemic NN cord-297652-ut6e1ysz 153 19 and and CC cord-297652-ut6e1ysz 153 20 zoonotic zoonotic JJ cord-297652-ut6e1ysz 153 21 coronaviruses coronaviruse NNS cord-297652-ut6e1ysz 154 1 Comparative comparative JJ cord-297652-ut6e1ysz 154 2 therapeutic therapeutic JJ cord-297652-ut6e1ysz 154 3 efficacy efficacy NN cord-297652-ut6e1ysz 154 4 of of IN cord-297652-ut6e1ysz 154 5 remdesivir remdesivir NNP cord-297652-ut6e1ysz 154 6 and and CC cord-297652-ut6e1ysz 154 7 combination combination NN cord-297652-ut6e1ysz 154 8 lopinavir lopinavir NNS cord-297652-ut6e1ysz 154 9 , , , cord-297652-ut6e1ysz 154 10 ritonavir ritonavir NNP cord-297652-ut6e1ysz 154 11 , , , cord-297652-ut6e1ysz 154 12 and and CC cord-297652-ut6e1ysz 154 13 interferon interferon NN cord-297652-ut6e1ysz 154 14 beta beta NN cord-297652-ut6e1ysz 154 15 against against IN cord-297652-ut6e1ysz 154 16 MERS MERS NNP cord-297652-ut6e1ysz 154 17 - - HYPH cord-297652-ut6e1ysz 154 18 CoV CoV NNP cord-297652-ut6e1ysz 154 19 Prophylactic Prophylactic NNP cord-297652-ut6e1ysz 154 20 and and CC cord-297652-ut6e1ysz 154 21 therapeutic therapeutic JJ cord-297652-ut6e1ysz 154 22 Remdesivir Remdesivir NNP cord-297652-ut6e1ysz 154 23 ( ( -LRB- cord-297652-ut6e1ysz 154 24 GS-5734 GS-5734 NNP cord-297652-ut6e1ysz 154 25 ) ) -RRB- cord-297652-ut6e1ysz 154 26 treatment treatment NN cord-297652-ut6e1ysz 154 27 in in IN cord-297652-ut6e1ysz 154 28 the the DT cord-297652-ut6e1ysz 154 29 rhesus rhesus NNP cord-297652-ut6e1ysz 154 30 macaque macaque NN cord-297652-ut6e1ysz 154 31 model model NN cord-297652-ut6e1ysz 154 32 of of IN cord-297652-ut6e1ysz 154 33 MERS MERS NNP cord-297652-ut6e1ysz 154 34 - - HYPH cord-297652-ut6e1ysz 154 35 CoV CoV NNP cord-297652-ut6e1ysz 154 36 infection infection NN cord-297652-ut6e1ysz 154 37 Remdesivir Remdesivir NNP cord-297652-ut6e1ysz 154 38 and and CC cord-297652-ut6e1ysz 154 39 chloroquine chloroquine NN cord-297652-ut6e1ysz 154 40 effectively effectively RB cord-297652-ut6e1ysz 154 41 inhibit inhibit VBP cord-297652-ut6e1ysz 154 42 the the DT cord-297652-ut6e1ysz 154 43 recently recently RB cord-297652-ut6e1ysz 154 44 emerged emerge VBN cord-297652-ut6e1ysz 154 45 novel novel JJ cord-297652-ut6e1ysz 154 46 coronavirus coronavirus NN cord-297652-ut6e1ysz 154 47 ( ( -LRB- cord-297652-ut6e1ysz 154 48 2019-nCoV 2019-ncov CD cord-297652-ut6e1ysz 154 49 ) ) -RRB- cord-297652-ut6e1ysz 154 50 in in IN cord-297652-ut6e1ysz 154 51 vitro vitro FW cord-297652-ut6e1ysz 154 52 First First NNP cord-297652-ut6e1ysz 154 53 Case Case NNP cord-297652-ut6e1ysz 154 54 of of IN cord-297652-ut6e1ysz 154 55 2019 2019 CD cord-297652-ut6e1ysz 154 56 Novel Novel NNP cord-297652-ut6e1ysz 154 57 Coronavirus Coronavirus NNP cord-297652-ut6e1ysz 154 58 in in IN cord-297652-ut6e1ysz 154 59 the the DT cord-297652-ut6e1ysz 154 60 United United NNP cord-297652-ut6e1ysz 154 61 States States NNP cord-297652-ut6e1ysz 154 62 Sciensano Sciensano NNP cord-297652-ut6e1ysz 154 63 Epidemiologie Epidemiologie NNP cord-297652-ut6e1ysz 154 64 des des FW cord-297652-ut6e1ysz 154 65 Maladies Maladies NNP cord-297652-ut6e1ysz 154 66 Infectieuses Infectieuses NNP cord-297652-ut6e1ysz 154 67 . . . cord-297652-ut6e1ysz 155 1 Available available JJ cord-297652-ut6e1ysz 155 2 online online JJ cord-297652-ut6e1ysz 155 3 Screening screening NN cord-297652-ut6e1ysz 155 4 of of IN cord-297652-ut6e1ysz 155 5 an an DT cord-297652-ut6e1ysz 155 6 FDA FDA NNP cord-297652-ut6e1ysz 155 7 - - HYPH cord-297652-ut6e1ysz 155 8 approved approve VBN cord-297652-ut6e1ysz 155 9 compound compound NN cord-297652-ut6e1ysz 155 10 library library NN cord-297652-ut6e1ysz 155 11 identifies identify VBZ cord-297652-ut6e1ysz 155 12 four four CD cord-297652-ut6e1ysz 155 13 small small JJ cord-297652-ut6e1ysz 155 14 - - HYPH cord-297652-ut6e1ysz 155 15 molecule molecule NN cord-297652-ut6e1ysz 155 16 inhibitors inhibitor NNS cord-297652-ut6e1ysz 155 17 of of IN cord-297652-ut6e1ysz 155 18 Middle Middle NNP cord-297652-ut6e1ysz 155 19 East East NNP cord-297652-ut6e1ysz 155 20 respiratory respiratory JJ cord-297652-ut6e1ysz 155 21 syndrome syndrome NN cord-297652-ut6e1ysz 155 22 coronavirus coronavirus NN cord-297652-ut6e1ysz 155 23 replication replication NN cord-297652-ut6e1ysz 155 24 in in IN cord-297652-ut6e1ysz 155 25 cell cell NN cord-297652-ut6e1ysz 155 26 culture culture NN cord-297652-ut6e1ysz 155 27 Treatment treatment NN cord-297652-ut6e1ysz 155 28 with with IN cord-297652-ut6e1ysz 155 29 Lopinavir Lopinavir NNP cord-297652-ut6e1ysz 155 30 / / SYM cord-297652-ut6e1ysz 155 31 Ritonavir Ritonavir NNP cord-297652-ut6e1ysz 155 32 or or CC cord-297652-ut6e1ysz 155 33 Interferon Interferon NNP cord-297652-ut6e1ysz 155 34 - - HYPH cord-297652-ut6e1ysz 155 35 β1b β1b NNP cord-297652-ut6e1ysz 155 36 improves improve VBZ cord-297652-ut6e1ysz 155 37 outcome outcome NN cord-297652-ut6e1ysz 155 38 of of IN cord-297652-ut6e1ysz 155 39 MERS MERS NNP cord-297652-ut6e1ysz 155 40 - - HYPH cord-297652-ut6e1ysz 155 41 CoV cov NN cord-297652-ut6e1ysz 155 42 infection infection NN cord-297652-ut6e1ysz 155 43 in in IN cord-297652-ut6e1ysz 155 44 a a DT cord-297652-ut6e1ysz 155 45 nonhuman nonhuman NN cord-297652-ut6e1ysz 155 46 primate primate NN cord-297652-ut6e1ysz 155 47 model model NN cord-297652-ut6e1ysz 155 48 of of IN cord-297652-ut6e1ysz 155 49 common common JJ cord-297652-ut6e1ysz 155 50 marmoset marmoset NN cord-297652-ut6e1ysz 155 51 A a DT cord-297652-ut6e1ysz 155 52 systematic systematic JJ cord-297652-ut6e1ysz 155 53 review review NN cord-297652-ut6e1ysz 155 54 of of IN cord-297652-ut6e1ysz 155 55 lopinavir lopinavir NNP cord-297652-ut6e1ysz 155 56 therapy therapy NN cord-297652-ut6e1ysz 155 57 for for IN cord-297652-ut6e1ysz 155 58 SARS SARS NNP cord-297652-ut6e1ysz 155 59 coronavirus coronavirus NN cord-297652-ut6e1ysz 155 60 and and CC cord-297652-ut6e1ysz 155 61 MERS MERS NNP cord-297652-ut6e1ysz 155 62 coronavirus coronavirus NN cord-297652-ut6e1ysz 155 63 - - : cord-297652-ut6e1ysz 155 64 A a DT cord-297652-ut6e1ysz 155 65 possible possible JJ cord-297652-ut6e1ysz 155 66 reference reference NN cord-297652-ut6e1ysz 155 67 for for IN cord-297652-ut6e1ysz 155 68 coronavirus coronavirus NN cord-297652-ut6e1ysz 155 69 disease-19 disease-19 CD cord-297652-ut6e1ysz 155 70 treatment treatment NN cord-297652-ut6e1ysz 155 71 option option NN cord-297652-ut6e1ysz 156 1 Systematic systematic JJ cord-297652-ut6e1ysz 156 2 review review NN cord-297652-ut6e1ysz 156 3 of of IN cord-297652-ut6e1ysz 156 4 treatment treatment NN cord-297652-ut6e1ysz 156 5 effects effect NNS cord-297652-ut6e1ysz 156 6 COVID-19-The COVID-19-The NFP cord-297652-ut6e1ysz 156 7 search search VBP cord-297652-ut6e1ysz 156 8 for for IN cord-297652-ut6e1ysz 156 9 effective effective JJ cord-297652-ut6e1ysz 156 10 therapy therapy NN cord-297652-ut6e1ysz 157 1 A a DT cord-297652-ut6e1ysz 157 2 trial trial NN cord-297652-ut6e1ysz 157 3 of of IN cord-297652-ut6e1ysz 157 4 Lopinavir Lopinavir NNP cord-297652-ut6e1ysz 157 5 - - HYPH cord-297652-ut6e1ysz 157 6 Ritonavir Ritonavir NNP cord-297652-ut6e1ysz 157 7 in in IN cord-297652-ut6e1ysz 157 8 adults adult NNS cord-297652-ut6e1ysz 157 9 hospitalized hospitalize VBN cord-297652-ut6e1ysz 157 10 with with IN cord-297652-ut6e1ysz 157 11 severe severe JJ cord-297652-ut6e1ysz 157 12 Covid-19 covid-19 NN cord-297652-ut6e1ysz 157 13 Why Why NNPS cord-297652-ut6e1ysz 157 14 re re JJ cord-297652-ut6e1ysz 157 15 - - JJ cord-297652-ut6e1ysz 157 16 purposing purpose VBG cord-297652-ut6e1ysz 157 17 HIV HIV NNP cord-297652-ut6e1ysz 157 18 drugs drug NNS cord-297652-ut6e1ysz 157 19 Lopinavir Lopinavir NNP cord-297652-ut6e1ysz 157 20 / / SYM cord-297652-ut6e1ysz 157 21 ritonavir ritonavir NNS cord-297652-ut6e1ysz 157 22 to to TO cord-297652-ut6e1ysz 157 23 inhibit inhibit VB cord-297652-ut6e1ysz 157 24 the the DT cord-297652-ut6e1ysz 157 25 SARS SARS NNP cord-297652-ut6e1ysz 157 26 - - HYPH cord-297652-ut6e1ysz 157 27 Cov2 Cov2 NNP cord-297652-ut6e1ysz 157 28 protease protease NN cord-297652-ut6e1ysz 157 29 probably probably RB cord-297652-ut6e1ysz 157 30 wo will MD cord-297652-ut6e1ysz 157 31 n't not RB cord-297652-ut6e1ysz 157 32 work- work- VB cord-297652-ut6e1ysz 158 1 but but CC cord-297652-ut6e1ysz 158 2 re re JJ cord-297652-ut6e1ysz 158 3 - - NN cord-297652-ut6e1ysz 158 4 purposing purposing JJ cord-297652-ut6e1ysz 158 5 Ribavirin Ribavirin NNP cord-297652-ut6e1ysz 158 6 might may MD cord-297652-ut6e1ysz 158 7 since since IN cord-297652-ut6e1ysz 158 8 it -PRON- PRP cord-297652-ut6e1ysz 158 9 has have VBZ cord-297652-ut6e1ysz 158 10 a a DT cord-297652-ut6e1ysz 158 11 very very RB cord-297652-ut6e1ysz 158 12 similar similar JJ cord-297652-ut6e1ysz 158 13 binding binding NN cord-297652-ut6e1ysz 158 14 site site NN cord-297652-ut6e1ysz 158 15 within within IN cord-297652-ut6e1ysz 158 16 the the DT cord-297652-ut6e1ysz 158 17 RNA RNA NNP cord-297652-ut6e1ysz 158 18 - - HYPH cord-297652-ut6e1ysz 158 19 polymerase polymerase NN cord-297652-ut6e1ysz 158 20 Pharmacy pharmacy NN cord-297652-ut6e1ysz 158 21 Checker Checker NNP cord-297652-ut6e1ysz 158 22 Helping help VBG cord-297652-ut6e1ysz 158 23 People People NNS cord-297652-ut6e1ysz 158 24 Safely safely RB cord-297652-ut6e1ysz 158 25 Find find VB cord-297652-ut6e1ysz 158 26 More More JJR cord-297652-ut6e1ysz 158 27 Affordable affordable JJ cord-297652-ut6e1ysz 158 28 Medicine medicine NN cord-297652-ut6e1ysz 159 1 The the DT cord-297652-ut6e1ysz 159 2 antiviral antiviral JJ cord-297652-ut6e1ysz 159 3 effect effect NN cord-297652-ut6e1ysz 159 4 of of IN cord-297652-ut6e1ysz 159 5 interferon interferon NN cord-297652-ut6e1ysz 159 6 - - HYPH cord-297652-ut6e1ysz 159 7 beta beta NN cord-297652-ut6e1ysz 159 8 against against IN cord-297652-ut6e1ysz 159 9 SARS SARS NNP cord-297652-ut6e1ysz 159 10 - - HYPH cord-297652-ut6e1ysz 159 11 Coronavirus Coronavirus NNP cord-297652-ut6e1ysz 159 12 is be VBZ cord-297652-ut6e1ysz 159 13 not not RB cord-297652-ut6e1ysz 159 14 mediated mediate VBN cord-297652-ut6e1ysz 159 15 by by IN cord-297652-ut6e1ysz 159 16 MxA MxA NNP cord-297652-ut6e1ysz 159 17 protein protein NN cord-297652-ut6e1ysz 160 1 Interferon interferon NN cord-297652-ut6e1ysz 160 2 - - HYPH cord-297652-ut6e1ysz 160 3 β β NNP cord-297652-ut6e1ysz 161 1 1a 1a NNP cord-297652-ut6e1ysz 161 2 and and CC cord-297652-ut6e1ysz 161 3 SARS SARS NNP cord-297652-ut6e1ysz 161 4 coronavirus coronavirus NN cord-297652-ut6e1ysz 161 5 replication replication NN cord-297652-ut6e1ysz 162 1 Interferon Interferon NNP cord-297652-ut6e1ysz 162 2 - - HYPH cord-297652-ut6e1ysz 162 3 β β NNP cord-297652-ut6e1ysz 162 4 and and CC cord-297652-ut6e1ysz 162 5 mycophenolic mycophenolic JJ cord-297652-ut6e1ysz 162 6 acid acid NN cord-297652-ut6e1ysz 162 7 are be VBP cord-297652-ut6e1ysz 162 8 potent potent JJ cord-297652-ut6e1ysz 162 9 inhibitors inhibitor NNS cord-297652-ut6e1ysz 162 10 of of IN cord-297652-ut6e1ysz 162 11 Middle Middle NNP cord-297652-ut6e1ysz 162 12 East East NNP cord-297652-ut6e1ysz 162 13 respiratory respiratory JJ cord-297652-ut6e1ysz 162 14 syndrome syndrome NN cord-297652-ut6e1ysz 162 15 coronavirus coronavirus NN cord-297652-ut6e1ysz 162 16 in in IN cord-297652-ut6e1ysz 162 17 cell cell NN cord-297652-ut6e1ysz 162 18 - - HYPH cord-297652-ut6e1ysz 162 19 based base VBN cord-297652-ut6e1ysz 162 20 assays assay NNS cord-297652-ut6e1ysz 162 21 Husband husband NN cord-297652-ut6e1ysz 162 22 and and CC cord-297652-ut6e1ysz 162 23 Wife Wife NNP cord-297652-ut6e1ysz 162 24 Poison poison NN cord-297652-ut6e1ysz 162 25 Themselves -PRON- PRP cord-297652-ut6e1ysz 162 26 Trying try VBG cord-297652-ut6e1ysz 162 27 to to IN cord-297652-ut6e1ysz 162 28 Self self NN cord-297652-ut6e1ysz 162 29 - - HYPH cord-297652-ut6e1ysz 162 30 medicate medicate VB cord-297652-ut6e1ysz 162 31 with with IN cord-297652-ut6e1ysz 162 32 Chloroquine Chloroquine NNP cord-297652-ut6e1ysz 162 33 Comparison Comparison NNP cord-297652-ut6e1ysz 162 34 of of IN cord-297652-ut6e1ysz 162 35 hydroxychloroquine hydroxychloroquine NNP cord-297652-ut6e1ysz 162 36 and and CC cord-297652-ut6e1ysz 162 37 chloroquine chloroquine NN cord-297652-ut6e1ysz 162 38 use use NN cord-297652-ut6e1ysz 162 39 and and CC cord-297652-ut6e1ysz 162 40 the the DT cord-297652-ut6e1ysz 162 41 development development NN cord-297652-ut6e1ysz 162 42 of of IN cord-297652-ut6e1ysz 162 43 retinal retinal JJ cord-297652-ut6e1ysz 162 44 toxicity toxicity NN cord-297652-ut6e1ysz 162 45 Pharmacokinetics Pharmacokinetics NNP cord-297652-ut6e1ysz 162 46 of of IN cord-297652-ut6e1ysz 162 47 Hydroxychloroquine Hydroxychloroquine NNP cord-297652-ut6e1ysz 162 48 and and CC cord-297652-ut6e1ysz 162 49 its -PRON- PRP$ cord-297652-ut6e1ysz 162 50 clinical clinical JJ cord-297652-ut6e1ysz 162 51 implications implication NNS cord-297652-ut6e1ysz 162 52 in in IN cord-297652-ut6e1ysz 162 53 chemoprophylaxis chemoprophylaxis NNP cord-297652-ut6e1ysz 162 54 against against IN cord-297652-ut6e1ysz 162 55 calaria calaria NNP cord-297652-ut6e1ysz 162 56 caused cause VBN cord-297652-ut6e1ysz 162 57 by by IN cord-297652-ut6e1ysz 162 58 Plasmodium Plasmodium NNP cord-297652-ut6e1ysz 162 59 vivax vivax NN cord-297652-ut6e1ysz 162 60 Chloroquine Chloroquine NNP cord-297652-ut6e1ysz 162 61 and and CC cord-297652-ut6e1ysz 162 62 beyond beyond IN cord-297652-ut6e1ysz 162 63 : : : cord-297652-ut6e1ysz 163 1 Exploring explore VBG cord-297652-ut6e1ysz 163 2 anti anti JJ cord-297652-ut6e1ysz 163 3 - - JJ cord-297652-ut6e1ysz 163 4 rheumatic rheumatic JJ cord-297652-ut6e1ysz 163 5 drugs drug NNS cord-297652-ut6e1ysz 163 6 to to TO cord-297652-ut6e1ysz 163 7 reduce reduce VB cord-297652-ut6e1ysz 163 8 immune immune JJ cord-297652-ut6e1ysz 163 9 hyperactivation hyperactivation NN cord-297652-ut6e1ysz 163 10 in in IN cord-297652-ut6e1ysz 163 11 HIV HIV NNP cord-297652-ut6e1ysz 163 12 / / SYM cord-297652-ut6e1ysz 163 13 AIDS AIDS NNP cord-297652-ut6e1ysz 163 14 Design Design NNP cord-297652-ut6e1ysz 163 15 and and CC cord-297652-ut6e1ysz 163 16 synthesis synthesis NN cord-297652-ut6e1ysz 163 17 of of IN cord-297652-ut6e1ysz 163 18 hydroxyferroquine hydroxyferroquine NNP cord-297652-ut6e1ysz 163 19 derivatives derivative NNS cord-297652-ut6e1ysz 163 20 with with IN cord-297652-ut6e1ysz 163 21 antimalarial antimalarial JJ cord-297652-ut6e1ysz 163 22 and and CC cord-297652-ut6e1ysz 163 23 antiviral antiviral JJ cord-297652-ut6e1ysz 163 24 activities activity NNS cord-297652-ut6e1ysz 163 25 Repurposing repurposing NN cord-297652-ut6e1ysz 163 26 of of IN cord-297652-ut6e1ysz 163 27 clinically clinically RB cord-297652-ut6e1ysz 163 28 developed develop VBN cord-297652-ut6e1ysz 163 29 drugs drug NNS cord-297652-ut6e1ysz 163 30 for for IN cord-297652-ut6e1ysz 163 31 Tteatment Tteatment NNP cord-297652-ut6e1ysz 163 32 of of IN cord-297652-ut6e1ysz 163 33 Middle Middle NNP cord-297652-ut6e1ysz 163 34 East East NNP cord-297652-ut6e1ysz 163 35 respiratory respiratory JJ cord-297652-ut6e1ysz 163 36 syndrome syndrome NN cord-297652-ut6e1ysz 163 37 coronavirus coronavirus NN cord-297652-ut6e1ysz 163 38 infection infection NN cord-297652-ut6e1ysz 163 39 In in IN cord-297652-ut6e1ysz 163 40 Vitro Vitro NNP cord-297652-ut6e1ysz 163 41 Antiviral antiviral JJ cord-297652-ut6e1ysz 163 42 activity activity NN cord-297652-ut6e1ysz 163 43 and and CC cord-297652-ut6e1ysz 163 44 projection projection NN cord-297652-ut6e1ysz 163 45 of of IN cord-297652-ut6e1ysz 163 46 optimized optimize VBN cord-297652-ut6e1ysz 163 47 dosing dosing NN cord-297652-ut6e1ysz 163 48 design design NN cord-297652-ut6e1ysz 163 49 of of IN cord-297652-ut6e1ysz 163 50 hydroxychloroquine hydroxychloroquine NN cord-297652-ut6e1ysz 163 51 for for IN cord-297652-ut6e1ysz 163 52 the the DT cord-297652-ut6e1ysz 163 53 treatment treatment NN cord-297652-ut6e1ysz 163 54 of of IN cord-297652-ut6e1ysz 163 55 severe severe JJ cord-297652-ut6e1ysz 163 56 acute acute JJ cord-297652-ut6e1ysz 163 57 respiratory respiratory JJ cord-297652-ut6e1ysz 163 58 syndrome syndrome NN cord-297652-ut6e1ysz 163 59 coronavirus coronavirus NN cord-297652-ut6e1ysz 163 60 2 2 CD cord-297652-ut6e1ysz 164 1 ( ( -LRB- cord-297652-ut6e1ysz 164 2 SARS SARS NNP cord-297652-ut6e1ysz 164 3 - - HYPH cord-297652-ut6e1ysz 164 4 CoV-2 CoV-2 NNP cord-297652-ut6e1ysz 165 1 ) ) -RRB- cord-297652-ut6e1ysz 165 2 Breakthrough Breakthrough NNP cord-297652-ut6e1ysz 165 3 : : : cord-297652-ut6e1ysz 165 4 Chloroquine chloroquine NN cord-297652-ut6e1ysz 165 5 phosphate phosphate NN cord-297652-ut6e1ysz 165 6 has have VBZ cord-297652-ut6e1ysz 165 7 shown show VBN cord-297652-ut6e1ysz 165 8 apparent apparent JJ cord-297652-ut6e1ysz 165 9 efficacy efficacy NN cord-297652-ut6e1ysz 165 10 in in IN cord-297652-ut6e1ysz 165 11 treatment treatment NN cord-297652-ut6e1ysz 165 12 of of IN cord-297652-ut6e1ysz 165 13 COVID-19 covid-19 JJ cord-297652-ut6e1ysz 165 14 associated associated JJ cord-297652-ut6e1ysz 165 15 pneumonia pneumonia NN cord-297652-ut6e1ysz 165 16 in in IN cord-297652-ut6e1ysz 165 17 clinical clinical JJ cord-297652-ut6e1ysz 165 18 studies study NNS cord-297652-ut6e1ysz 165 19 Request request NN cord-297652-ut6e1ysz 165 20 for for IN cord-297652-ut6e1ysz 165 21 Emergency Emergency NNP cord-297652-ut6e1ysz 165 22 Use Use NNP cord-297652-ut6e1ysz 165 23 Authorization Authorization NNP cord-297652-ut6e1ysz 165 24 Hydroxychloroquine Hydroxychloroquine NNP cord-297652-ut6e1ysz 165 25 and and CC cord-297652-ut6e1ysz 165 26 azithromycin azithromycin NNP cord-297652-ut6e1ysz 165 27 as as IN cord-297652-ut6e1ysz 165 28 a a DT cord-297652-ut6e1ysz 165 29 treatment treatment NN cord-297652-ut6e1ysz 165 30 of of IN cord-297652-ut6e1ysz 165 31 COVID-19 covid-19 NN cord-297652-ut6e1ysz 165 32 : : : cord-297652-ut6e1ysz 165 33 Results result NNS cord-297652-ut6e1ysz 165 34 of of IN cord-297652-ut6e1ysz 165 35 an an DT cord-297652-ut6e1ysz 165 36 open open JJ cord-297652-ut6e1ysz 165 37 - - HYPH cord-297652-ut6e1ysz 165 38 label label NN cord-297652-ut6e1ysz 165 39 non non JJ cord-297652-ut6e1ysz 165 40 - - JJ cord-297652-ut6e1ysz 165 41 randomized randomized JJ cord-297652-ut6e1ysz 165 42 clinical clinical JJ cord-297652-ut6e1ysz 165 43 trial trial NN cord-297652-ut6e1ysz 165 44 No no DT cord-297652-ut6e1ysz 165 45 evidence evidence NN cord-297652-ut6e1ysz 165 46 of of IN cord-297652-ut6e1ysz 165 47 rapid rapid JJ cord-297652-ut6e1ysz 165 48 antiviral antiviral JJ cord-297652-ut6e1ysz 165 49 clearance clearance NN cord-297652-ut6e1ysz 165 50 or or CC cord-297652-ut6e1ysz 165 51 clinical clinical JJ cord-297652-ut6e1ysz 165 52 benefit benefit NN cord-297652-ut6e1ysz 165 53 with with IN cord-297652-ut6e1ysz 165 54 the the DT cord-297652-ut6e1ysz 165 55 combination combination NN cord-297652-ut6e1ysz 165 56 of of IN cord-297652-ut6e1ysz 165 57 hydroxychloroquine hydroxychloroquine NN cord-297652-ut6e1ysz 165 58 and and CC cord-297652-ut6e1ysz 165 59 azithromycin azithromycin NNP cord-297652-ut6e1ysz 165 60 in in IN cord-297652-ut6e1ysz 165 61 patients patient NNS cord-297652-ut6e1ysz 165 62 with with IN cord-297652-ut6e1ysz 165 63 severe severe JJ cord-297652-ut6e1ysz 165 64 COVID-19 covid-19 JJ cord-297652-ut6e1ysz 165 65 infection infection NN cord-297652-ut6e1ysz 165 66 The the DT cord-297652-ut6e1ysz 165 67 Bill Bill NNP cord-297652-ut6e1ysz 165 68 and and CC cord-297652-ut6e1ysz 165 69 Melinda Melinda NNP cord-297652-ut6e1ysz 165 70 Gates Gates NNP cord-297652-ut6e1ysz 165 71 Foundation Foundation NNP cord-297652-ut6e1ysz 165 72 . . . cord-297652-ut6e1ysz 166 1 Three three CD cord-297652-ut6e1ysz 166 2 Weeks Weeks NNPS cord-297652-ut6e1ysz 166 3 , , , cord-297652-ut6e1ysz 166 4 Two two CD cord-297652-ut6e1ysz 166 5 Drug Drug NNP cord-297652-ut6e1ysz 166 6 Trials Trials NNPS cord-297652-ut6e1ysz 166 7 : : : cord-297652-ut6e1ysz 166 8 An an DT cord-297652-ut6e1ysz 166 9 Update update NN cord-297652-ut6e1ysz 166 10 on on IN cord-297652-ut6e1ysz 166 11 the the DT cord-297652-ut6e1ysz 166 12 Therapeutics Therapeutics NNP cord-297652-ut6e1ysz 166 13 Accelerator Accelerator NNP cord-297652-ut6e1ysz 166 14 with with IN cord-297652-ut6e1ysz 166 15 Trevor Trevor NNP cord-297652-ut6e1ysz 166 16 Mundel Mundel NNP cord-297652-ut6e1ysz 166 17 Funding Funding NNP cord-297652-ut6e1ysz 166 18 : : : cord-297652-ut6e1ysz 166 19 This this DT cord-297652-ut6e1ysz 166 20 research research NN cord-297652-ut6e1ysz 166 21 received receive VBD cord-297652-ut6e1ysz 166 22 no no DT cord-297652-ut6e1ysz 166 23 external external JJ cord-297652-ut6e1ysz 166 24 funding funding NN cord-297652-ut6e1ysz 166 25 . . . cord-297652-ut6e1ysz 167 1 The the DT cord-297652-ut6e1ysz 167 2 author author NN cord-297652-ut6e1ysz 167 3 declares declare VBZ cord-297652-ut6e1ysz 167 4 no no DT cord-297652-ut6e1ysz 167 5 conflict conflict NN cord-297652-ut6e1ysz 167 6 of of IN cord-297652-ut6e1ysz 167 7 interest interest NN cord-297652-ut6e1ysz 167 8 . . .