id sid tid token lemma pos cord-294854-rvrgcugn 1 1 key key NN cord-294854-rvrgcugn 1 2 : : : cord-294854-rvrgcugn 1 3 cord-294854-rvrgcugn cord-294854-rvrgcugn ADD cord-294854-rvrgcugn 2 1 authors author NNS cord-294854-rvrgcugn 2 2 : : : cord-294854-rvrgcugn 2 3 Hu Hu NNP cord-294854-rvrgcugn 2 4 , , , cord-294854-rvrgcugn 2 5 Biying Biying NNP cord-294854-rvrgcugn 2 6 ; ; : cord-294854-rvrgcugn 2 7 Huang Huang NNP cord-294854-rvrgcugn 2 8 , , , cord-294854-rvrgcugn 2 9 Shaoying Shaoying NNP cord-294854-rvrgcugn 2 10 ; ; : cord-294854-rvrgcugn 2 11 Yin Yin NNP cord-294854-rvrgcugn 2 12 , , , cord-294854-rvrgcugn 3 1 Lianghong Lianghong NNP cord-294854-rvrgcugn 3 2 title title NN cord-294854-rvrgcugn 3 3 : : : cord-294854-rvrgcugn 4 1 The the DT cord-294854-rvrgcugn 4 2 cytokine cytokine NN cord-294854-rvrgcugn 4 3 storm storm NN cord-294854-rvrgcugn 4 4 and and CC cord-294854-rvrgcugn 4 5 COVID‐19 covid‐19 NN cord-294854-rvrgcugn 4 6 date date NN cord-294854-rvrgcugn 4 7 : : : cord-294854-rvrgcugn 4 8 2020 2020 CD cord-294854-rvrgcugn 4 9 - - HYPH cord-294854-rvrgcugn 4 10 06 06 CD cord-294854-rvrgcugn 4 11 - - SYM cord-294854-rvrgcugn 4 12 27 27 CD cord-294854-rvrgcugn 4 13 journal journal NN cord-294854-rvrgcugn 4 14 : : : cord-294854-rvrgcugn 4 15 J J NNP cord-294854-rvrgcugn 4 16 Med Med NNP cord-294854-rvrgcugn 4 17 Virol Virol NNP cord-294854-rvrgcugn 4 18 DOI DOI NNP cord-294854-rvrgcugn 4 19 : : : cord-294854-rvrgcugn 4 20 10.1002 10.1002 CD cord-294854-rvrgcugn 4 21 / / SYM cord-294854-rvrgcugn 4 22 jmv.26232 jmv.26232 NNP cord-294854-rvrgcugn 5 1 sha sha NNP cord-294854-rvrgcugn 5 2 : : : cord-294854-rvrgcugn 6 1 25a76995eafe9c76f8320c72efe97a3461dcba30 25a76995eafe9c76f8320c72efe97a3461dcba30 CD cord-294854-rvrgcugn 6 2 doc_id doc_id CD cord-294854-rvrgcugn 6 3 : : : cord-294854-rvrgcugn 6 4 294854 294854 CD cord-294854-rvrgcugn 6 5 cord_uid cord_uid NNS cord-294854-rvrgcugn 6 6 : : : cord-294854-rvrgcugn 7 1 rvrgcugn rvrgcugn NNP cord-294854-rvrgcugn 7 2 Coronavirus Coronavirus NNP cord-294854-rvrgcugn 7 3 disease disease NN cord-294854-rvrgcugn 7 4 2019 2019 CD cord-294854-rvrgcugn 8 1 ( ( -LRB- cord-294854-rvrgcugn 8 2 COVID‐19 COVID‐19 NNP cord-294854-rvrgcugn 8 3 ) ) -RRB- cord-294854-rvrgcugn 8 4 , , , cord-294854-rvrgcugn 8 5 which which WDT cord-294854-rvrgcugn 8 6 began begin VBD cord-294854-rvrgcugn 8 7 in in IN cord-294854-rvrgcugn 8 8 Wuhan Wuhan NNP cord-294854-rvrgcugn 8 9 , , , cord-294854-rvrgcugn 8 10 China China NNP cord-294854-rvrgcugn 8 11 in in IN cord-294854-rvrgcugn 8 12 December December NNP cord-294854-rvrgcugn 8 13 2019 2019 CD cord-294854-rvrgcugn 8 14 has have VBZ cord-294854-rvrgcugn 8 15 caused cause VBN cord-294854-rvrgcugn 8 16 a a DT cord-294854-rvrgcugn 8 17 large large JJ cord-294854-rvrgcugn 8 18 global global JJ cord-294854-rvrgcugn 8 19 pandemic pandemic NN cord-294854-rvrgcugn 8 20 and and CC cord-294854-rvrgcugn 8 21 poses pose VBZ cord-294854-rvrgcugn 8 22 a a DT cord-294854-rvrgcugn 8 23 serious serious JJ cord-294854-rvrgcugn 8 24 threat threat NN cord-294854-rvrgcugn 8 25 to to IN cord-294854-rvrgcugn 8 26 public public JJ cord-294854-rvrgcugn 8 27 health health NN cord-294854-rvrgcugn 8 28 . . . cord-294854-rvrgcugn 9 1 More More JJR cord-294854-rvrgcugn 9 2 than than IN cord-294854-rvrgcugn 9 3 four four CD cord-294854-rvrgcugn 9 4 million million CD cord-294854-rvrgcugn 9 5 cases case NNS cord-294854-rvrgcugn 9 6 of of IN cord-294854-rvrgcugn 9 7 COVID‐19 covid‐19 NN cord-294854-rvrgcugn 9 8 , , , cord-294854-rvrgcugn 9 9 which which WDT cord-294854-rvrgcugn 9 10 is be VBZ cord-294854-rvrgcugn 9 11 caused cause VBN cord-294854-rvrgcugn 9 12 by by IN cord-294854-rvrgcugn 9 13 the the DT cord-294854-rvrgcugn 9 14 severe severe JJ cord-294854-rvrgcugn 9 15 acute acute JJ cord-294854-rvrgcugn 9 16 respiratory respiratory JJ cord-294854-rvrgcugn 9 17 syndrome syndrome NN cord-294854-rvrgcugn 9 18 coronavirus coronavirus NN cord-294854-rvrgcugn 9 19 2 2 CD cord-294854-rvrgcugn 9 20 ( ( -LRB- cord-294854-rvrgcugn 9 21 SARS‐CoV‐2 SARS‐CoV‐2 NNP cord-294854-rvrgcugn 9 22 ) ) -RRB- cord-294854-rvrgcugn 9 23 , , , cord-294854-rvrgcugn 9 24 have have VBP cord-294854-rvrgcugn 9 25 been be VBN cord-294854-rvrgcugn 9 26 confirmed confirm VBN cord-294854-rvrgcugn 9 27 as as IN cord-294854-rvrgcugn 9 28 of of IN cord-294854-rvrgcugn 9 29 May May NNP cord-294854-rvrgcugn 9 30 11 11 CD cord-294854-rvrgcugn 9 31 , , , cord-294854-rvrgcugn 9 32 2020 2020 CD cord-294854-rvrgcugn 9 33 . . . cord-294854-rvrgcugn 10 1 SARS‐CoV‐2 SARS‐CoV‐2 NNP cord-294854-rvrgcugn 10 2 is be VBZ cord-294854-rvrgcugn 10 3 a a DT cord-294854-rvrgcugn 10 4 highly highly RB cord-294854-rvrgcugn 10 5 pathogenic pathogenic JJ cord-294854-rvrgcugn 10 6 and and CC cord-294854-rvrgcugn 10 7 transmissible transmissible JJ cord-294854-rvrgcugn 10 8 coronavirus coronavirus NN cord-294854-rvrgcugn 10 9 that that WDT cord-294854-rvrgcugn 10 10 primarily primarily RB cord-294854-rvrgcugn 10 11 spreads spread VBZ cord-294854-rvrgcugn 10 12 through through IN cord-294854-rvrgcugn 10 13 respiratory respiratory JJ cord-294854-rvrgcugn 10 14 droplets droplet NNS cord-294854-rvrgcugn 10 15 and and CC cord-294854-rvrgcugn 10 16 close close JJ cord-294854-rvrgcugn 10 17 contact contact NN cord-294854-rvrgcugn 10 18 . . . cord-294854-rvrgcugn 11 1 A a DT cord-294854-rvrgcugn 11 2 growing grow VBG cord-294854-rvrgcugn 11 3 body body NN cord-294854-rvrgcugn 11 4 of of IN cord-294854-rvrgcugn 11 5 clinical clinical JJ cord-294854-rvrgcugn 11 6 data data NN cord-294854-rvrgcugn 11 7 suggests suggest VBZ cord-294854-rvrgcugn 11 8 that that IN cord-294854-rvrgcugn 11 9 a a DT cord-294854-rvrgcugn 11 10 cytokine cytokine NN cord-294854-rvrgcugn 11 11 storm storm NN cord-294854-rvrgcugn 11 12 is be VBZ cord-294854-rvrgcugn 11 13 associated associate VBN cord-294854-rvrgcugn 11 14 with with IN cord-294854-rvrgcugn 11 15 COVID‐19 covid‐19 JJ cord-294854-rvrgcugn 11 16 severity severity NN cord-294854-rvrgcugn 11 17 and and CC cord-294854-rvrgcugn 11 18 is be VBZ cord-294854-rvrgcugn 11 19 also also RB cord-294854-rvrgcugn 11 20 a a DT cord-294854-rvrgcugn 11 21 crucial crucial JJ cord-294854-rvrgcugn 11 22 cause cause NN cord-294854-rvrgcugn 11 23 of of IN cord-294854-rvrgcugn 11 24 death death NN cord-294854-rvrgcugn 11 25 from from IN cord-294854-rvrgcugn 11 26 COVID‐19 COVID‐19 NNP cord-294854-rvrgcugn 11 27 . . . cord-294854-rvrgcugn 12 1 In in IN cord-294854-rvrgcugn 12 2 the the DT cord-294854-rvrgcugn 12 3 absence absence NN cord-294854-rvrgcugn 12 4 of of IN cord-294854-rvrgcugn 12 5 antivirals antiviral NNS cord-294854-rvrgcugn 12 6 and and CC cord-294854-rvrgcugn 12 7 vaccines vaccine NNS cord-294854-rvrgcugn 12 8 for for IN cord-294854-rvrgcugn 12 9 COVID‐19 covid‐19 NN cord-294854-rvrgcugn 12 10 , , , cord-294854-rvrgcugn 12 11 there there EX cord-294854-rvrgcugn 12 12 is be VBZ cord-294854-rvrgcugn 12 13 an an DT cord-294854-rvrgcugn 12 14 urgent urgent JJ cord-294854-rvrgcugn 12 15 need need NN cord-294854-rvrgcugn 12 16 to to TO cord-294854-rvrgcugn 12 17 understand understand VB cord-294854-rvrgcugn 12 18 the the DT cord-294854-rvrgcugn 12 19 cytokine cytokine NN cord-294854-rvrgcugn 12 20 storm storm NN cord-294854-rvrgcugn 12 21 in in IN cord-294854-rvrgcugn 12 22 COVID‐19 COVID‐19 NNP cord-294854-rvrgcugn 12 23 . . . cord-294854-rvrgcugn 13 1 Here here RB cord-294854-rvrgcugn 13 2 , , , cord-294854-rvrgcugn 13 3 we -PRON- PRP cord-294854-rvrgcugn 13 4 have have VBP cord-294854-rvrgcugn 13 5 reviewed review VBN cord-294854-rvrgcugn 13 6 the the DT cord-294854-rvrgcugn 13 7 current current JJ cord-294854-rvrgcugn 13 8 understanding understanding NN cord-294854-rvrgcugn 13 9 of of IN cord-294854-rvrgcugn 13 10 the the DT cord-294854-rvrgcugn 13 11 features feature NNS cord-294854-rvrgcugn 13 12 of of IN cord-294854-rvrgcugn 13 13 SARS‐CoV‐2 sars‐cov‐2 NN cord-294854-rvrgcugn 13 14 and and CC cord-294854-rvrgcugn 13 15 the the DT cord-294854-rvrgcugn 13 16 pathological pathological JJ cord-294854-rvrgcugn 13 17 features feature NNS cord-294854-rvrgcugn 13 18 , , , cord-294854-rvrgcugn 13 19 pathophysiological pathophysiological JJ cord-294854-rvrgcugn 13 20 mechanisms mechanism NNS cord-294854-rvrgcugn 13 21 , , , cord-294854-rvrgcugn 13 22 and and CC cord-294854-rvrgcugn 13 23 treatments treatment NNS cord-294854-rvrgcugn 13 24 of of IN cord-294854-rvrgcugn 13 25 the the DT cord-294854-rvrgcugn 13 26 cytokine cytokine NN cord-294854-rvrgcugn 13 27 storm storm NN cord-294854-rvrgcugn 13 28 induced induce VBN cord-294854-rvrgcugn 13 29 by by IN cord-294854-rvrgcugn 13 30 COVID‐19 COVID‐19 NNP cord-294854-rvrgcugn 13 31 . . . cord-294854-rvrgcugn 14 1 Additionally additionally RB cord-294854-rvrgcugn 14 2 , , , cord-294854-rvrgcugn 14 3 we -PRON- PRP cord-294854-rvrgcugn 14 4 suggest suggest VBP cord-294854-rvrgcugn 14 5 that that IN cord-294854-rvrgcugn 14 6 the the DT cord-294854-rvrgcugn 14 7 identification identification NN cord-294854-rvrgcugn 14 8 and and CC cord-294854-rvrgcugn 14 9 treatment treatment NN cord-294854-rvrgcugn 14 10 of of IN cord-294854-rvrgcugn 14 11 the the DT cord-294854-rvrgcugn 14 12 cytokine cytokine NN cord-294854-rvrgcugn 14 13 storm storm NN cord-294854-rvrgcugn 14 14 are be VBP cord-294854-rvrgcugn 14 15 important important JJ cord-294854-rvrgcugn 14 16 components component NNS cord-294854-rvrgcugn 14 17 for for IN cord-294854-rvrgcugn 14 18 rescuing rescue VBG cord-294854-rvrgcugn 14 19 patients patient NNS cord-294854-rvrgcugn 14 20 with with IN cord-294854-rvrgcugn 14 21 severe severe JJ cord-294854-rvrgcugn 14 22 COVID‐19 covid‐19 NN cord-294854-rvrgcugn 14 23 . . . cord-294854-rvrgcugn 15 1 This this DT cord-294854-rvrgcugn 15 2 article article NN cord-294854-rvrgcugn 15 3 is be VBZ cord-294854-rvrgcugn 15 4 protected protect VBN cord-294854-rvrgcugn 15 5 by by IN cord-294854-rvrgcugn 15 6 copyright copyright NN cord-294854-rvrgcugn 15 7 . . . cord-294854-rvrgcugn 16 1 All all DT cord-294854-rvrgcugn 16 2 rights right NNS cord-294854-rvrgcugn 16 3 reserved reserve VBN cord-294854-rvrgcugn 16 4 . . . cord-294854-rvrgcugn 17 1 An an DT cord-294854-rvrgcugn 17 2 outbreak outbreak NN cord-294854-rvrgcugn 17 3 of of IN cord-294854-rvrgcugn 17 4 coronavirus coronavirus NN cord-294854-rvrgcugn 17 5 disease disease NN cord-294854-rvrgcugn 17 6 2019 2019 CD cord-294854-rvrgcugn 17 7 ( ( -LRB- cord-294854-rvrgcugn 17 8 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 17 9 ) ) -RRB- cord-294854-rvrgcugn 17 10 caused cause VBN cord-294854-rvrgcugn 17 11 by by IN cord-294854-rvrgcugn 17 12 severe severe JJ cord-294854-rvrgcugn 17 13 acute acute JJ cord-294854-rvrgcugn 17 14 respiratory respiratory JJ cord-294854-rvrgcugn 17 15 syndrome syndrome NN cord-294854-rvrgcugn 17 16 coronavirus coronavirus NN cord-294854-rvrgcugn 17 17 2 2 CD cord-294854-rvrgcugn 18 1 ( ( -LRB- cord-294854-rvrgcugn 18 2 SARS SARS NNP cord-294854-rvrgcugn 18 3 - - HYPH cord-294854-rvrgcugn 18 4 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 18 5 ) ) -RRB- cord-294854-rvrgcugn 18 6 has have VBZ cord-294854-rvrgcugn 18 7 rapidly rapidly RB cord-294854-rvrgcugn 18 8 spread spread VBN cord-294854-rvrgcugn 18 9 throughout throughout IN cord-294854-rvrgcugn 18 10 the the DT cord-294854-rvrgcugn 18 11 world world NN cord-294854-rvrgcugn 18 12 1 1 CD cord-294854-rvrgcugn 18 13 . . . cord-294854-rvrgcugn 19 1 The the DT cord-294854-rvrgcugn 19 2 initial initial JJ cord-294854-rvrgcugn 19 3 symptoms symptom NNS cord-294854-rvrgcugn 19 4 of of IN cord-294854-rvrgcugn 19 5 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 19 6 mainly mainly RB cord-294854-rvrgcugn 19 7 include include VBP cord-294854-rvrgcugn 19 8 fever fever NN cord-294854-rvrgcugn 19 9 , , , cord-294854-rvrgcugn 19 10 cough cough NN cord-294854-rvrgcugn 19 11 , , , cord-294854-rvrgcugn 19 12 myalgia myalgia NN cord-294854-rvrgcugn 19 13 , , , cord-294854-rvrgcugn 19 14 fatigue fatigue NN cord-294854-rvrgcugn 19 15 , , , cord-294854-rvrgcugn 19 16 or or CC cord-294854-rvrgcugn 19 17 dyspnea dyspnea NN cord-294854-rvrgcugn 19 18 . . . cord-294854-rvrgcugn 20 1 In in IN cord-294854-rvrgcugn 20 2 the the DT cord-294854-rvrgcugn 20 3 later later JJ cord-294854-rvrgcugn 20 4 stages stage NNS cord-294854-rvrgcugn 20 5 of of IN cord-294854-rvrgcugn 20 6 the the DT cord-294854-rvrgcugn 20 7 disease disease NN cord-294854-rvrgcugn 20 8 , , , cord-294854-rvrgcugn 20 9 dyspnea dyspnea NN cord-294854-rvrgcugn 20 10 may may MD cord-294854-rvrgcugn 20 11 occur occur VB cord-294854-rvrgcugn 20 12 and and CC cord-294854-rvrgcugn 20 13 gradually gradually RB cord-294854-rvrgcugn 20 14 develop develop VB cord-294854-rvrgcugn 20 15 into into IN cord-294854-rvrgcugn 20 16 acute acute JJ cord-294854-rvrgcugn 20 17 respiratory respiratory JJ cord-294854-rvrgcugn 20 18 distress distress NN cord-294854-rvrgcugn 20 19 syndrome syndrome NN cord-294854-rvrgcugn 20 20 ( ( -LRB- cord-294854-rvrgcugn 20 21 ARDS ARDS NNP cord-294854-rvrgcugn 20 22 ) ) -RRB- cord-294854-rvrgcugn 20 23 or or CC cord-294854-rvrgcugn 20 24 multiple multiple JJ cord-294854-rvrgcugn 20 25 organ organ NN cord-294854-rvrgcugn 20 26 failure failure NN cord-294854-rvrgcugn 20 27 ( ( -LRB- cord-294854-rvrgcugn 20 28 MOF MOF NNP cord-294854-rvrgcugn 20 29 ) ) -RRB- cord-294854-rvrgcugn 20 30 2 2 CD cord-294854-rvrgcugn 20 31 . . . cord-294854-rvrgcugn 21 1 It -PRON- PRP cord-294854-rvrgcugn 21 2 has have VBZ cord-294854-rvrgcugn 21 3 been be VBN cord-294854-rvrgcugn 21 4 reported report VBN cord-294854-rvrgcugn 21 5 that that IN cord-294854-rvrgcugn 21 6 a a DT cord-294854-rvrgcugn 21 7 cytokine cytokine NN cord-294854-rvrgcugn 21 8 storm storm NN cord-294854-rvrgcugn 21 9 is be VBZ cord-294854-rvrgcugn 21 10 Accepted accept VBN cord-294854-rvrgcugn 21 11 Article Article NNP cord-294854-rvrgcugn 21 12 associated associate VBN cord-294854-rvrgcugn 21 13 with with IN cord-294854-rvrgcugn 21 14 the the DT cord-294854-rvrgcugn 21 15 deterioration deterioration NN cord-294854-rvrgcugn 21 16 of of IN cord-294854-rvrgcugn 21 17 many many JJ cord-294854-rvrgcugn 21 18 infectious infectious JJ cord-294854-rvrgcugn 21 19 diseases disease NNS cord-294854-rvrgcugn 21 20 , , , cord-294854-rvrgcugn 21 21 including include VBG cord-294854-rvrgcugn 21 22 severe severe JJ cord-294854-rvrgcugn 21 23 acute acute JJ cord-294854-rvrgcugn 21 24 respiratory respiratory JJ cord-294854-rvrgcugn 21 25 syndrome syndrome NN cord-294854-rvrgcugn 21 26 ( ( -LRB- cord-294854-rvrgcugn 21 27 SARS SARS NNP cord-294854-rvrgcugn 21 28 ) ) -RRB- cord-294854-rvrgcugn 21 29 3 3 CD cord-294854-rvrgcugn 21 30 and and CC cord-294854-rvrgcugn 21 31 Middle Middle NNP cord-294854-rvrgcugn 21 32 East East NNP cord-294854-rvrgcugn 21 33 respiratory respiratory JJ cord-294854-rvrgcugn 21 34 syndrome syndrome NN cord-294854-rvrgcugn 21 35 ( ( -LRB- cord-294854-rvrgcugn 21 36 MERS MERS NNP cord-294854-rvrgcugn 21 37 ) ) -RRB- cord-294854-rvrgcugn 21 38 4 4 CD cord-294854-rvrgcugn 21 39 . . . cord-294854-rvrgcugn 22 1 The the DT cord-294854-rvrgcugn 22 2 cytokine cytokine NN cord-294854-rvrgcugn 22 3 storm storm NN cord-294854-rvrgcugn 22 4 caused cause VBN cord-294854-rvrgcugn 22 5 by by IN cord-294854-rvrgcugn 22 6 has have VBZ cord-294854-rvrgcugn 22 7 been be VBN cord-294854-rvrgcugn 22 8 suggested suggest VBN cord-294854-rvrgcugn 22 9 to to TO cord-294854-rvrgcugn 22 10 be be VB cord-294854-rvrgcugn 22 11 associated associate VBN cord-294854-rvrgcugn 22 12 with with IN cord-294854-rvrgcugn 22 13 COVID-19 covid-19 JJ cord-294854-rvrgcugn 22 14 severity severity NN cord-294854-rvrgcugn 22 15 2 2 CD cord-294854-rvrgcugn 22 16 , , , cord-294854-rvrgcugn 22 17 5 5 CD cord-294854-rvrgcugn 22 18 . . . cord-294854-rvrgcugn 23 1 However however RB cord-294854-rvrgcugn 23 2 , , , cord-294854-rvrgcugn 23 3 there there EX cord-294854-rvrgcugn 23 4 is be VBZ cord-294854-rvrgcugn 23 5 currently currently RB cord-294854-rvrgcugn 23 6 a a DT cord-294854-rvrgcugn 23 7 limited limited JJ cord-294854-rvrgcugn 23 8 understanding understanding NN cord-294854-rvrgcugn 23 9 of of IN cord-294854-rvrgcugn 23 10 the the DT cord-294854-rvrgcugn 23 11 cytokine cytokine NN cord-294854-rvrgcugn 23 12 storm storm NN cord-294854-rvrgcugn 23 13 in in IN cord-294854-rvrgcugn 23 14 severe severe JJ cord-294854-rvrgcugn 23 15 COVID-19 covid-19 NN cord-294854-rvrgcugn 23 16 . . . cord-294854-rvrgcugn 24 1 Therefore therefore RB cord-294854-rvrgcugn 24 2 , , , cord-294854-rvrgcugn 24 3 here here RB cord-294854-rvrgcugn 24 4 , , , cord-294854-rvrgcugn 24 5 we -PRON- PRP cord-294854-rvrgcugn 24 6 have have VBP cord-294854-rvrgcugn 24 7 discussed discuss VBN cord-294854-rvrgcugn 24 8 the the DT cord-294854-rvrgcugn 24 9 current current JJ cord-294854-rvrgcugn 24 10 findings finding NNS cord-294854-rvrgcugn 24 11 and and CC cord-294854-rvrgcugn 24 12 treatment treatment NN cord-294854-rvrgcugn 24 13 strategies strategy NNS cord-294854-rvrgcugn 24 14 for for IN cord-294854-rvrgcugn 24 15 the the DT cord-294854-rvrgcugn 24 16 cytokine cytokine NN cord-294854-rvrgcugn 24 17 storm storm NN cord-294854-rvrgcugn 24 18 in in IN cord-294854-rvrgcugn 24 19 severe severe JJ cord-294854-rvrgcugn 24 20 COVID-19 covid-19 NN cord-294854-rvrgcugn 24 21 . . . cord-294854-rvrgcugn 25 1 SARS SARS NNP cord-294854-rvrgcugn 25 2 - - HYPH cord-294854-rvrgcugn 25 3 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 25 4 is be VBZ cord-294854-rvrgcugn 25 5 the the DT cord-294854-rvrgcugn 25 6 newest new JJS cord-294854-rvrgcugn 25 7 coronavirus coronavirus NN cord-294854-rvrgcugn 25 8 known know VBN cord-294854-rvrgcugn 25 9 to to TO cord-294854-rvrgcugn 25 10 infect infect VB cord-294854-rvrgcugn 25 11 humans human NNS cord-294854-rvrgcugn 25 12 . . . cord-294854-rvrgcugn 26 1 SARS SARS NNP cord-294854-rvrgcugn 26 2 - - HYPH cord-294854-rvrgcugn 26 3 CoV CoV NNP cord-294854-rvrgcugn 26 4 , , , cord-294854-rvrgcugn 26 5 MERS MERS NNP cord-294854-rvrgcugn 26 6 - - HYPH cord-294854-rvrgcugn 26 7 CoV CoV NNP cord-294854-rvrgcugn 26 8 , , , cord-294854-rvrgcugn 26 9 and and CC cord-294854-rvrgcugn 26 10 SARS SARS NNP cord-294854-rvrgcugn 26 11 - - HYPH cord-294854-rvrgcugn 26 12 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 26 13 cause cause VB cord-294854-rvrgcugn 26 14 severe severe JJ cord-294854-rvrgcugn 26 15 pneumonia pneumonia NN cord-294854-rvrgcugn 26 16 , , , cord-294854-rvrgcugn 26 17 while while IN cord-294854-rvrgcugn 26 18 other other JJ cord-294854-rvrgcugn 26 19 human human JJ cord-294854-rvrgcugn 26 20 coronaviruses coronaviruse NNS cord-294854-rvrgcugn 26 21 , , , cord-294854-rvrgcugn 26 22 including include VBG cord-294854-rvrgcugn 26 23 229E 229e CD cord-294854-rvrgcugn 26 24 , , , cord-294854-rvrgcugn 26 25 OC43 OC43 NNP cord-294854-rvrgcugn 26 26 , , , cord-294854-rvrgcugn 26 27 HKU1 HKU1 NNP cord-294854-rvrgcugn 26 28 , , , cord-294854-rvrgcugn 26 29 and and CC cord-294854-rvrgcugn 26 30 NL63 NL63 NNP cord-294854-rvrgcugn 26 31 , , , cord-294854-rvrgcugn 26 32 cause cause VB cord-294854-rvrgcugn 26 33 only only RB cord-294854-rvrgcugn 26 34 the the DT cord-294854-rvrgcugn 26 35 common common JJ cord-294854-rvrgcugn 26 36 cold cold JJ cord-294854-rvrgcugn 26 37 6 6 CD cord-294854-rvrgcugn 26 38 . . . cord-294854-rvrgcugn 27 1 SARS SARS NNP cord-294854-rvrgcugn 27 2 - - HYPH cord-294854-rvrgcugn 27 3 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 27 4 belongs belong VBZ cord-294854-rvrgcugn 27 5 to to IN cord-294854-rvrgcugn 27 6 the the DT cord-294854-rvrgcugn 27 7 genus genus NN cord-294854-rvrgcugn 27 8 Betacoronavirus Betacoronavirus NNP cord-294854-rvrgcugn 27 9 , , , cord-294854-rvrgcugn 27 10 which which WDT cord-294854-rvrgcugn 27 11 also also RB cord-294854-rvrgcugn 27 12 includes include VBZ cord-294854-rvrgcugn 27 13 SARS SARS NNP cord-294854-rvrgcugn 27 14 - - HYPH cord-294854-rvrgcugn 27 15 CoV CoV NNP cord-294854-rvrgcugn 27 16 and and CC cord-294854-rvrgcugn 27 17 MERS MERS NNP cord-294854-rvrgcugn 27 18 - - HYPH cord-294854-rvrgcugn 27 19 CoV CoV NNP cord-294854-rvrgcugn 27 20 , , , cord-294854-rvrgcugn 27 21 both both DT cord-294854-rvrgcugn 27 22 of of IN cord-294854-rvrgcugn 27 23 which which WDT cord-294854-rvrgcugn 27 24 have have VBP cord-294854-rvrgcugn 27 25 caused cause VBN cord-294854-rvrgcugn 27 26 SARS SARS NNP cord-294854-rvrgcugn 27 27 and and CC cord-294854-rvrgcugn 27 28 MERS MERS NNP cord-294854-rvrgcugn 27 29 , , , cord-294854-rvrgcugn 27 30 respectively respectively RB cord-294854-rvrgcugn 27 31 7 7 CD cord-294854-rvrgcugn 27 32 . . . cord-294854-rvrgcugn 28 1 SARS SARS NNP cord-294854-rvrgcugn 28 2 - - HYPH cord-294854-rvrgcugn 28 3 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 28 4 , , , cord-294854-rvrgcugn 28 5 SARS SARS NNP cord-294854-rvrgcugn 28 6 - - HYPH cord-294854-rvrgcugn 28 7 CoV CoV NNP cord-294854-rvrgcugn 28 8 , , , cord-294854-rvrgcugn 28 9 and and CC cord-294854-rvrgcugn 28 10 MERS MERS NNP cord-294854-rvrgcugn 28 11 - - HYPH cord-294854-rvrgcugn 28 12 CoV CoV NNP cord-294854-rvrgcugn 28 13 have have VBP cord-294854-rvrgcugn 28 14 similarities similarity NNS cord-294854-rvrgcugn 28 15 and and CC cord-294854-rvrgcugn 28 16 differences difference NNS cord-294854-rvrgcugn 28 17 . . . cord-294854-rvrgcugn 29 1 Genetic genetic JJ cord-294854-rvrgcugn 29 2 sequence sequence NN cord-294854-rvrgcugn 29 3 analysis analysis NN cord-294854-rvrgcugn 29 4 has have VBZ cord-294854-rvrgcugn 29 5 revealed reveal VBN cord-294854-rvrgcugn 29 6 that that IN cord-294854-rvrgcugn 29 7 SARS SARS NNP cord-294854-rvrgcugn 29 8 - - HYPH cord-294854-rvrgcugn 29 9 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 29 10 shares share VBZ cord-294854-rvrgcugn 29 11 79 79 CD cord-294854-rvrgcugn 29 12 % % NN cord-294854-rvrgcugn 29 13 sequence sequence NN cord-294854-rvrgcugn 29 14 identity identity NN cord-294854-rvrgcugn 29 15 with with IN cord-294854-rvrgcugn 29 16 SARS SARS NNP cord-294854-rvrgcugn 29 17 - - HYPH cord-294854-rvrgcugn 29 18 CoV CoV NNP cord-294854-rvrgcugn 29 19 and and CC cord-294854-rvrgcugn 29 20 50 50 CD cord-294854-rvrgcugn 29 21 % % NN cord-294854-rvrgcugn 29 22 identity identity NN cord-294854-rvrgcugn 29 23 with with IN cord-294854-rvrgcugn 29 24 MERS MERS NNP cord-294854-rvrgcugn 29 25 - - HYPH cord-294854-rvrgcugn 29 26 CoV CoV NNP cord-294854-rvrgcugn 29 27 8 8 CD cord-294854-rvrgcugn 29 28 . . . cord-294854-rvrgcugn 30 1 The the DT cord-294854-rvrgcugn 30 2 genomes genome NNS cord-294854-rvrgcugn 30 3 of of IN cord-294854-rvrgcugn 30 4 SARS SARS NNP cord-294854-rvrgcugn 30 5 - - HYPH cord-294854-rvrgcugn 30 6 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 30 7 and and CC cord-294854-rvrgcugn 30 8 the the DT cord-294854-rvrgcugn 30 9 bat bat NN cord-294854-rvrgcugn 30 10 coronavirus coronavirus NN cord-294854-rvrgcugn 30 11 RaTG13 ratg13 NN cord-294854-rvrgcugn 30 12 are be VBP cord-294854-rvrgcugn 30 13 96.2 96.2 CD cord-294854-rvrgcugn 30 14 % % NN cord-294854-rvrgcugn 30 15 homologous homologous JJ cord-294854-rvrgcugn 30 16 9 9 CD cord-294854-rvrgcugn 30 17 . . . cord-294854-rvrgcugn 31 1 As as IN cord-294854-rvrgcugn 31 2 of of IN cord-294854-rvrgcugn 31 3 May May NNP cord-294854-rvrgcugn 31 4 11 11 CD cord-294854-rvrgcugn 31 5 , , , cord-294854-rvrgcugn 31 6 2020 2020 CD cord-294854-rvrgcugn 31 7 , , , cord-294854-rvrgcugn 31 8 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 31 9 has have VBZ cord-294854-rvrgcugn 31 10 resulted result VBN cord-294854-rvrgcugn 31 11 in in IN cord-294854-rvrgcugn 31 12 278,892 278,892 CD cord-294854-rvrgcugn 31 13 deaths death NNS cord-294854-rvrgcugn 31 14 and and CC cord-294854-rvrgcugn 31 15 4,006,257 4,006,257 CD cord-294854-rvrgcugn 31 16 cases case NNS cord-294854-rvrgcugn 31 17 , , , cord-294854-rvrgcugn 31 18 with with IN cord-294854-rvrgcugn 31 19 an an DT cord-294854-rvrgcugn 31 20 approximate approximate JJ cord-294854-rvrgcugn 31 21 case case NN cord-294854-rvrgcugn 31 22 fatality fatality NN cord-294854-rvrgcugn 31 23 rate rate NN cord-294854-rvrgcugn 31 24 of of IN cord-294854-rvrgcugn 31 25 7.0 7.0 CD cord-294854-rvrgcugn 31 26 % % NN cord-294854-rvrgcugn 31 27 10 10 CD cord-294854-rvrgcugn 31 28 . . . cord-294854-rvrgcugn 32 1 SARS SARS NNP cord-294854-rvrgcugn 32 2 - - HYPH cord-294854-rvrgcugn 32 3 CoV CoV NNP cord-294854-rvrgcugn 32 4 and and CC cord-294854-rvrgcugn 32 5 MERS MERS NNP cord-294854-rvrgcugn 32 6 - - HYPH cord-294854-rvrgcugn 32 7 CoV CoV NNP cord-294854-rvrgcugn 32 8 had have VBD cord-294854-rvrgcugn 32 9 a a DT cord-294854-rvrgcugn 32 10 case case NN cord-294854-rvrgcugn 32 11 fatality fatality NN cord-294854-rvrgcugn 32 12 rate rate NN cord-294854-rvrgcugn 32 13 of of IN cord-294854-rvrgcugn 32 14 9.6 9.6 CD cord-294854-rvrgcugn 32 15 % % NN cord-294854-rvrgcugn 32 16 ( ( -LRB- cord-294854-rvrgcugn 32 17 774/8,096 774/8,096 NN cord-294854-rvrgcugn 32 18 ) ) -RRB- cord-294854-rvrgcugn 32 19 and and CC cord-294854-rvrgcugn 32 20 34.4 34.4 CD cord-294854-rvrgcugn 32 21 % % NN cord-294854-rvrgcugn 32 22 ( ( -LRB- cord-294854-rvrgcugn 32 23 858/2,494 858/2,494 NN cord-294854-rvrgcugn 32 24 ) ) -RRB- cord-294854-rvrgcugn 32 25 , , , cord-294854-rvrgcugn 32 26 respectively respectively RB cord-294854-rvrgcugn 32 27 11 11 CD cord-294854-rvrgcugn 32 28 . . . cord-294854-rvrgcugn 33 1 The the DT cord-294854-rvrgcugn 33 2 reproduction reproduction NN cord-294854-rvrgcugn 33 3 number number NN cord-294854-rvrgcugn 33 4 ( ( -LRB- cord-294854-rvrgcugn 33 5 R0 R0 NNP cord-294854-rvrgcugn 33 6 ) ) -RRB- cord-294854-rvrgcugn 33 7 of of IN cord-294854-rvrgcugn 33 8 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 33 9 is be VBZ cord-294854-rvrgcugn 33 10 thought think VBN cord-294854-rvrgcugn 33 11 to to TO cord-294854-rvrgcugn 33 12 be be VB cord-294854-rvrgcugn 33 13 This this DT cord-294854-rvrgcugn 33 14 article article NN cord-294854-rvrgcugn 33 15 is be VBZ cord-294854-rvrgcugn 33 16 protected protect VBN cord-294854-rvrgcugn 33 17 by by IN cord-294854-rvrgcugn 33 18 copyright copyright NN cord-294854-rvrgcugn 33 19 . . . cord-294854-rvrgcugn 34 1 All all DT cord-294854-rvrgcugn 34 2 rights right NNS cord-294854-rvrgcugn 34 3 reserved reserve VBN cord-294854-rvrgcugn 34 4 . . . cord-294854-rvrgcugn 35 1 Accepted accepted JJ cord-294854-rvrgcugn 35 2 Article Article NNP cord-294854-rvrgcugn 35 3 between between IN cord-294854-rvrgcugn 35 4 2 2 CD cord-294854-rvrgcugn 35 5 and and CC cord-294854-rvrgcugn 35 6 2.5 2.5 CD cord-294854-rvrgcugn 35 7 12 12 CD cord-294854-rvrgcugn 35 8 , , , cord-294854-rvrgcugn 35 9 which which WDT cord-294854-rvrgcugn 35 10 is be VBZ cord-294854-rvrgcugn 35 11 slightly slightly RB cord-294854-rvrgcugn 35 12 higher high JJR cord-294854-rvrgcugn 35 13 than than IN cord-294854-rvrgcugn 35 14 of of IN cord-294854-rvrgcugn 35 15 SARS SARS NNP cord-294854-rvrgcugn 35 16 ( ( -LRB- cord-294854-rvrgcugn 35 17 1.7.1.9 1.7.1.9 CD cord-294854-rvrgcugn 35 18 ) ) -RRB- cord-294854-rvrgcugn 35 19 and and CC cord-294854-rvrgcugn 35 20 MERS MERS NNP cord-294854-rvrgcugn 35 21 ( ( -LRB- cord-294854-rvrgcugn 35 22 < < NNP cord-294854-rvrgcugn 35 23 1 1 CD cord-294854-rvrgcugn 35 24 ) ) -RRB- cord-294854-rvrgcugn 35 25 13 13 CD cord-294854-rvrgcugn 35 26 . . . cord-294854-rvrgcugn 36 1 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 36 2 appears appear VBZ cord-294854-rvrgcugn 36 3 to to TO cord-294854-rvrgcugn 36 4 be be VB cord-294854-rvrgcugn 36 5 more more RBR cord-294854-rvrgcugn 36 6 infectious infectious JJ cord-294854-rvrgcugn 36 7 than than IN cord-294854-rvrgcugn 36 8 SARS SARS NNP cord-294854-rvrgcugn 36 9 and and CC cord-294854-rvrgcugn 36 10 MERS MERS NNP cord-294854-rvrgcugn 36 11 , , , cord-294854-rvrgcugn 36 12 but but CC cord-294854-rvrgcugn 36 13 may may MD cord-294854-rvrgcugn 36 14 be be VB cord-294854-rvrgcugn 36 15 less less RBR cord-294854-rvrgcugn 36 16 severe severe JJ cord-294854-rvrgcugn 36 17 . . . cord-294854-rvrgcugn 37 1 The the DT cord-294854-rvrgcugn 37 2 origins origin NNS cord-294854-rvrgcugn 37 3 of of IN cord-294854-rvrgcugn 37 4 SARS SARS NNP cord-294854-rvrgcugn 37 5 - - HYPH cord-294854-rvrgcugn 37 6 CoV CoV NNP cord-294854-rvrgcugn 37 7 , , , cord-294854-rvrgcugn 37 8 MERS MERS NNP cord-294854-rvrgcugn 37 9 - - HYPH cord-294854-rvrgcugn 37 10 CoV CoV NNP cord-294854-rvrgcugn 37 11 , , , cord-294854-rvrgcugn 37 12 and and CC cord-294854-rvrgcugn 37 13 SARS SARS NNP cord-294854-rvrgcugn 37 14 - - HYPH cord-294854-rvrgcugn 37 15 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 37 16 are be VBP cord-294854-rvrgcugn 37 17 considered consider VBN cord-294854-rvrgcugn 37 18 to to TO cord-294854-rvrgcugn 37 19 be be VB cord-294854-rvrgcugn 37 20 zoonotic zoonotic JJ cord-294854-rvrgcugn 37 21 . . . cord-294854-rvrgcugn 38 1 Both both DT cord-294854-rvrgcugn 38 2 SARS SARS NNP cord-294854-rvrgcugn 38 3 - - HYPH cord-294854-rvrgcugn 38 4 CoV CoV NNP cord-294854-rvrgcugn 38 5 and and CC cord-294854-rvrgcugn 38 6 MERS MERS NNP cord-294854-rvrgcugn 38 7 - - HYPH cord-294854-rvrgcugn 38 8 CoV CoV NNP cord-294854-rvrgcugn 38 9 originated originate VBD cord-294854-rvrgcugn 38 10 in in IN cord-294854-rvrgcugn 38 11 bats bat NNS cord-294854-rvrgcugn 38 12 and and CC cord-294854-rvrgcugn 38 13 spread spread VBD cord-294854-rvrgcugn 38 14 directly directly RB cord-294854-rvrgcugn 38 15 to to IN cord-294854-rvrgcugn 38 16 humans human NNS cord-294854-rvrgcugn 38 17 from from IN cord-294854-rvrgcugn 38 18 marked marked JJ cord-294854-rvrgcugn 38 19 palm palm NN cord-294854-rvrgcugn 38 20 civets civet NNS cord-294854-rvrgcugn 38 21 and and CC cord-294854-rvrgcugn 38 22 dromedary dromedary NN cord-294854-rvrgcugn 38 23 camels camel NNS cord-294854-rvrgcugn 38 24 , , , cord-294854-rvrgcugn 38 25 respectively respectively RB cord-294854-rvrgcugn 38 26 14 14 CD cord-294854-rvrgcugn 38 27 . . . cord-294854-rvrgcugn 39 1 However however RB cord-294854-rvrgcugn 39 2 , , , cord-294854-rvrgcugn 39 3 the the DT cord-294854-rvrgcugn 39 4 origin origin NN cord-294854-rvrgcugn 39 5 of of IN cord-294854-rvrgcugn 39 6 SARS SARS NNP cord-294854-rvrgcugn 39 7 - - HYPH cord-294854-rvrgcugn 39 8 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 39 9 remains remain VBZ cord-294854-rvrgcugn 39 10 unclear unclear JJ cord-294854-rvrgcugn 39 11 . . . cord-294854-rvrgcugn 40 1 SARS SARS NNP cord-294854-rvrgcugn 40 2 - - HYPH cord-294854-rvrgcugn 40 3 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 40 4 has have VBZ cord-294854-rvrgcugn 40 5 been be VBN cord-294854-rvrgcugn 40 6 reported report VBN cord-294854-rvrgcugn 40 7 to to TO cord-294854-rvrgcugn 40 8 be be VB cord-294854-rvrgcugn 40 9 transmitted transmit VBN cord-294854-rvrgcugn 40 10 between between IN cord-294854-rvrgcugn 40 11 humans human NNS cord-294854-rvrgcugn 40 12 through through IN cord-294854-rvrgcugn 40 13 direct direct JJ cord-294854-rvrgcugn 40 14 contact contact NN cord-294854-rvrgcugn 40 15 , , , cord-294854-rvrgcugn 40 16 aerosol aerosol NN cord-294854-rvrgcugn 40 17 droplets droplet NNS cord-294854-rvrgcugn 40 18 , , , cord-294854-rvrgcugn 40 19 the the DT cord-294854-rvrgcugn 40 20 fecal fecal JJ cord-294854-rvrgcugn 40 21 - - HYPH cord-294854-rvrgcugn 40 22 oral oral JJ cord-294854-rvrgcugn 40 23 route route NN cord-294854-rvrgcugn 40 24 , , , cord-294854-rvrgcugn 40 25 and and CC cord-294854-rvrgcugn 40 26 intermediate intermediate JJ cord-294854-rvrgcugn 40 27 viruses virus NNS cord-294854-rvrgcugn 40 28 from from IN cord-294854-rvrgcugn 40 29 symptomatic symptomatic JJ cord-294854-rvrgcugn 40 30 and and CC cord-294854-rvrgcugn 40 31 asymptomatic asymptomatic JJ cord-294854-rvrgcugn 40 32 patients patient NNS cord-294854-rvrgcugn 40 33 15 15 CD cord-294854-rvrgcugn 40 34 . . . cord-294854-rvrgcugn 41 1 SARS SARS NNP cord-294854-rvrgcugn 41 2 - - HYPH cord-294854-rvrgcugn 41 3 CoV CoV NNP cord-294854-rvrgcugn 41 4 and and CC cord-294854-rvrgcugn 41 5 MERS MERS NNP cord-294854-rvrgcugn 41 6 - - HYPH cord-294854-rvrgcugn 41 7 CoV CoV NNP cord-294854-rvrgcugn 41 8 are be VBP cord-294854-rvrgcugn 41 9 also also RB cord-294854-rvrgcugn 41 10 thought think VBN cord-294854-rvrgcugn 41 11 to to TO cord-294854-rvrgcugn 41 12 spread spread VB cord-294854-rvrgcugn 41 13 from from IN cord-294854-rvrgcugn 41 14 infected infect VBN cord-294854-rvrgcugn 41 15 to to IN cord-294854-rvrgcugn 41 16 non non JJ cord-294854-rvrgcugn 41 17 - - JJ cord-294854-rvrgcugn 41 18 infected infected JJ cord-294854-rvrgcugn 41 19 individuals individual NNS cord-294854-rvrgcugn 41 20 through through IN cord-294854-rvrgcugn 41 21 direct direct JJ cord-294854-rvrgcugn 41 22 or or CC cord-294854-rvrgcugn 41 23 indirect indirect JJ cord-294854-rvrgcugn 41 24 contact contact NN cord-294854-rvrgcugn 41 25 15 15 CD cord-294854-rvrgcugn 41 26 19 19 CD cord-294854-rvrgcugn 41 27 proposed propose VBD cord-294854-rvrgcugn 41 28 that that IN cord-294854-rvrgcugn 41 29 SARS SARS NNP cord-294854-rvrgcugn 41 30 - - HYPH cord-294854-rvrgcugn 41 31 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 41 32 infection infection NN cord-294854-rvrgcugn 41 33 triggers trigger VBZ cord-294854-rvrgcugn 41 34 an an DT cord-294854-rvrgcugn 41 35 excessive excessive JJ cord-294854-rvrgcugn 41 36 immune immune JJ cord-294854-rvrgcugn 41 37 response response NN cord-294854-rvrgcugn 41 38 known know VBN cord-294854-rvrgcugn 41 39 as as IN cord-294854-rvrgcugn 41 40 a a DT cord-294854-rvrgcugn 41 41 cytokine cytokine NN cord-294854-rvrgcugn 41 42 storm storm NN cord-294854-rvrgcugn 41 43 in in IN cord-294854-rvrgcugn 41 44 cases case NNS cord-294854-rvrgcugn 41 45 of of IN cord-294854-rvrgcugn 41 46 severe severe JJ cord-294854-rvrgcugn 41 47 COVID-19 covid-19 NN cord-294854-rvrgcugn 41 48 . . . cord-294854-rvrgcugn 42 1 A a DT cord-294854-rvrgcugn 42 2 cytokine cytokine NN cord-294854-rvrgcugn 42 3 storm storm NN cord-294854-rvrgcugn 42 4 is be VBZ cord-294854-rvrgcugn 42 5 a a DT cord-294854-rvrgcugn 42 6 potentially potentially RB cord-294854-rvrgcugn 42 7 fatal fatal JJ cord-294854-rvrgcugn 42 8 immune immune JJ cord-294854-rvrgcugn 42 9 disease disease NN cord-294854-rvrgcugn 42 10 characterized characterize VBN cord-294854-rvrgcugn 42 11 by by IN cord-294854-rvrgcugn 42 12 the the DT cord-294854-rvrgcugn 42 13 high high JJ cord-294854-rvrgcugn 42 14 - - HYPH cord-294854-rvrgcugn 42 15 level level NN cord-294854-rvrgcugn 42 16 activation activation NN cord-294854-rvrgcugn 42 17 of of IN cord-294854-rvrgcugn 42 18 immune immune JJ cord-294854-rvrgcugn 42 19 cells cell NNS cord-294854-rvrgcugn 42 20 and and CC cord-294854-rvrgcugn 42 21 excessive excessive JJ cord-294854-rvrgcugn 42 22 production production NN cord-294854-rvrgcugn 42 23 of of IN cord-294854-rvrgcugn 42 24 massive massive JJ cord-294854-rvrgcugn 42 25 inflammatory inflammatory JJ cord-294854-rvrgcugn 42 26 cytokines cytokine NNS cord-294854-rvrgcugn 42 27 and and CC cord-294854-rvrgcugn 42 28 chemical chemical NN cord-294854-rvrgcugn 42 29 mediators mediator NNS cord-294854-rvrgcugn 42 30 20 20 CD cord-294854-rvrgcugn 42 31 . . . cord-294854-rvrgcugn 43 1 It -PRON- PRP cord-294854-rvrgcugn 43 2 is be VBZ cord-294854-rvrgcugn 43 3 considered consider VBN cord-294854-rvrgcugn 43 4 to to TO cord-294854-rvrgcugn 43 5 be be VB cord-294854-rvrgcugn 43 6 the the DT cord-294854-rvrgcugn 43 7 main main JJ cord-294854-rvrgcugn 43 8 cause cause NN cord-294854-rvrgcugn 43 9 of of IN cord-294854-rvrgcugn 43 10 disease disease NN cord-294854-rvrgcugn 43 11 severity severity NN cord-294854-rvrgcugn 43 12 and and CC cord-294854-rvrgcugn 43 13 death death NN cord-294854-rvrgcugn 43 14 in in IN cord-294854-rvrgcugn 43 15 Accepted Accepted NNP cord-294854-rvrgcugn 43 16 Article Article NNP cord-294854-rvrgcugn 44 1 COVID-19 covid-19 JJ cord-294854-rvrgcugn 44 2 patients patient NNS cord-294854-rvrgcugn 44 3 5 5 CD cord-294854-rvrgcugn 44 4 , , , cord-294854-rvrgcugn 44 5 and and CC cord-294854-rvrgcugn 44 6 is be VBZ cord-294854-rvrgcugn 44 7 related relate VBN cord-294854-rvrgcugn 44 8 to to IN cord-294854-rvrgcugn 44 9 high high JJ cord-294854-rvrgcugn 44 10 levels level NNS cord-294854-rvrgcugn 44 11 of of IN cord-294854-rvrgcugn 44 12 circulating circulate VBG cord-294854-rvrgcugn 44 13 cytokines cytokine NNS cord-294854-rvrgcugn 44 14 , , , cord-294854-rvrgcugn 44 15 severe severe JJ cord-294854-rvrgcugn 44 16 lymphopenia lymphopenia NNP cord-294854-rvrgcugn 44 17 , , , cord-294854-rvrgcugn 44 18 thrombosis thrombosis NN cord-294854-rvrgcugn 44 19 , , , cord-294854-rvrgcugn 44 20 and and CC cord-294854-rvrgcugn 44 21 massive massive JJ cord-294854-rvrgcugn 44 22 mononuclear mononuclear JJ cord-294854-rvrgcugn 44 23 cell cell NN cord-294854-rvrgcugn 44 24 infiltration infiltration NN cord-294854-rvrgcugn 44 25 in in IN cord-294854-rvrgcugn 44 26 multiple multiple JJ cord-294854-rvrgcugn 44 27 organs organ NNS cord-294854-rvrgcugn 44 28 21 21 CD cord-294854-rvrgcugn 44 29 . . . cord-294854-rvrgcugn 45 1 It -PRON- PRP cord-294854-rvrgcugn 45 2 has have VBZ cord-294854-rvrgcugn 45 3 been be VBN cord-294854-rvrgcugn 45 4 found find VBN cord-294854-rvrgcugn 45 5 that that IN cord-294854-rvrgcugn 45 6 SARS SARS NNP cord-294854-rvrgcugn 45 7 - - HYPH cord-294854-rvrgcugn 45 8 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 45 9 genomes genome NNS cord-294854-rvrgcugn 45 10 from from IN cord-294854-rvrgcugn 45 11 different different JJ cord-294854-rvrgcugn 45 12 parts part NNS cord-294854-rvrgcugn 45 13 of of IN cord-294854-rvrgcugn 45 14 the the DT cord-294854-rvrgcugn 45 15 world world NN cord-294854-rvrgcugn 45 16 have have VBP cord-294854-rvrgcugn 45 17 evolved evolve VBN cord-294854-rvrgcugn 45 18 in in IN cord-294854-rvrgcugn 45 19 different different JJ cord-294854-rvrgcugn 45 20 clusters cluster NNS cord-294854-rvrgcugn 45 21 22 22 CD cord-294854-rvrgcugn 45 22 , , , cord-294854-rvrgcugn 45 23 23 23 CD cord-294854-rvrgcugn 45 24 . . . cord-294854-rvrgcugn 46 1 Forster Forster NNP cord-294854-rvrgcugn 46 2 et et NNP cord-294854-rvrgcugn 46 3 al al NNP cord-294854-rvrgcugn 46 4 . . . cord-294854-rvrgcugn 47 1 23 23 CD cord-294854-rvrgcugn 47 2 reported report VBD cord-294854-rvrgcugn 47 3 there there RB cord-294854-rvrgcugn 47 4 to to TO cord-294854-rvrgcugn 47 5 be be VB cord-294854-rvrgcugn 47 6 at at RB cord-294854-rvrgcugn 47 7 least least RBS cord-294854-rvrgcugn 47 8 three three CD cord-294854-rvrgcugn 47 9 central central JJ cord-294854-rvrgcugn 47 10 variants variant NNS cord-294854-rvrgcugn 47 11 of of IN cord-294854-rvrgcugn 47 12 SARS SARS NNP cord-294854-rvrgcugn 47 13 - - : cord-294854-rvrgcugn 47 14 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 47 15 globally globally RB cord-294854-rvrgcugn 47 16 , , , cord-294854-rvrgcugn 47 17 named name VBN cord-294854-rvrgcugn 47 18 A A NNP cord-294854-rvrgcugn 47 19 , , , cord-294854-rvrgcugn 47 20 B b NN cord-294854-rvrgcugn 47 21 , , , cord-294854-rvrgcugn 47 22 and and CC cord-294854-rvrgcugn 47 23 C. C. NNP cord-294854-rvrgcugn 48 1 The the DT cord-294854-rvrgcugn 48 2 A a DT cord-294854-rvrgcugn 48 3 type type NN cord-294854-rvrgcugn 48 4 is be VBZ cord-294854-rvrgcugn 48 5 the the DT cord-294854-rvrgcugn 48 6 most most RBS cord-294854-rvrgcugn 48 7 similar similar JJ cord-294854-rvrgcugn 48 8 to to IN cord-294854-rvrgcugn 48 9 the the DT cord-294854-rvrgcugn 48 10 bat bat NN cord-294854-rvrgcugn 48 11 coronavirus coronavirus NN cord-294854-rvrgcugn 48 12 and and CC cord-294854-rvrgcugn 48 13 is be VBZ cord-294854-rvrgcugn 48 14 mainly mainly RB cord-294854-rvrgcugn 48 15 found find VBN cord-294854-rvrgcugn 48 16 in in IN cord-294854-rvrgcugn 48 17 the the DT cord-294854-rvrgcugn 48 18 United United NNP cord-294854-rvrgcugn 48 19 States States NNP cord-294854-rvrgcugn 48 20 and and CC cord-294854-rvrgcugn 48 21 Australia Australia NNP cord-294854-rvrgcugn 48 22 . . . cord-294854-rvrgcugn 49 1 The the DT cord-294854-rvrgcugn 49 2 B b NN cord-294854-rvrgcugn 49 3 type type NN cord-294854-rvrgcugn 49 4 is be VBZ cord-294854-rvrgcugn 49 5 more more RBR cord-294854-rvrgcugn 49 6 common common JJ cord-294854-rvrgcugn 49 7 in in IN cord-294854-rvrgcugn 49 8 East East NNP cord-294854-rvrgcugn 49 9 Asia Asia NNP cord-294854-rvrgcugn 49 10 and and CC cord-294854-rvrgcugn 49 11 has have VBZ cord-294854-rvrgcugn 49 12 evolved evolve VBN cord-294854-rvrgcugn 49 13 through through IN cord-294854-rvrgcugn 49 14 several several JJ cord-294854-rvrgcugn 49 15 mutations mutation NNS cord-294854-rvrgcugn 49 16 . . . cord-294854-rvrgcugn 50 1 The the DT cord-294854-rvrgcugn 50 2 C c NN cord-294854-rvrgcugn 50 3 type type NN cord-294854-rvrgcugn 50 4 is be VBZ cord-294854-rvrgcugn 50 5 primarily primarily RB cord-294854-rvrgcugn 50 6 found find VBN cord-294854-rvrgcugn 50 7 in in IN cord-294854-rvrgcugn 50 8 Europe Europe NNP cord-294854-rvrgcugn 50 9 . . . cord-294854-rvrgcugn 51 1 Different different JJ cord-294854-rvrgcugn 51 2 viral viral JJ cord-294854-rvrgcugn 51 3 isolates isolate NNS cord-294854-rvrgcugn 51 4 exhibit exhibit VBP cord-294854-rvrgcugn 51 5 significant significant JJ cord-294854-rvrgcugn 51 6 differences difference NNS cord-294854-rvrgcugn 51 7 in in IN cord-294854-rvrgcugn 51 8 pathogenicity pathogenicity NN cord-294854-rvrgcugn 51 9 and and CC cord-294854-rvrgcugn 51 10 viral viral JJ cord-294854-rvrgcugn 51 11 load load NN cord-294854-rvrgcugn 51 12 24 24 CD cord-294854-rvrgcugn 51 13 . . . cord-294854-rvrgcugn 52 1 Notably notably RB cord-294854-rvrgcugn 52 2 , , , cord-294854-rvrgcugn 52 3 given give VBN cord-294854-rvrgcugn 52 4 the the DT cord-294854-rvrgcugn 52 5 diverse diverse JJ cord-294854-rvrgcugn 52 6 clinical clinical JJ cord-294854-rvrgcugn 52 7 symptoms symptom NNS cord-294854-rvrgcugn 52 8 of of IN cord-294854-rvrgcugn 52 9 patients patient NNS cord-294854-rvrgcugn 52 10 , , , cord-294854-rvrgcugn 52 11 it -PRON- PRP cord-294854-rvrgcugn 52 12 will will MD cord-294854-rvrgcugn 52 13 be be VB cord-294854-rvrgcugn 52 14 challenging challenge VBG cord-294854-rvrgcugn 52 15 to to TO cord-294854-rvrgcugn 52 16 establish establish VB cord-294854-rvrgcugn 52 17 a a DT cord-294854-rvrgcugn 52 18 genotype genotype NN cord-294854-rvrgcugn 52 19 - - HYPH cord-294854-rvrgcugn 52 20 phenotype phenotype NN cord-294854-rvrgcugn 52 21 relationship relationship NN cord-294854-rvrgcugn 52 22 . . . cord-294854-rvrgcugn 53 1 With with IN cord-294854-rvrgcugn 53 2 new new JJ cord-294854-rvrgcugn 53 3 sequences sequence NNS cord-294854-rvrgcugn 53 4 being be VBG cord-294854-rvrgcugn 53 5 uploaded upload VBN cord-294854-rvrgcugn 53 6 to to IN cord-294854-rvrgcugn 53 7 the the DT cord-294854-rvrgcugn 53 8 GIASID GIASID NNP cord-294854-rvrgcugn 53 9 ( ( -LRB- cord-294854-rvrgcugn 53 10 Global global JJ cord-294854-rvrgcugn 53 11 initiative initiative NN cord-294854-rvrgcugn 53 12 on on IN cord-294854-rvrgcugn 53 13 sharing share VBG cord-294854-rvrgcugn 53 14 all all DT cord-294854-rvrgcugn 53 15 influenza influenza NN cord-294854-rvrgcugn 53 16 data datum NNS cord-294854-rvrgcugn 53 17 ) ) -RRB- cord-294854-rvrgcugn 53 18 every every DT cord-294854-rvrgcugn 53 19 day day NN cord-294854-rvrgcugn 53 20 , , , cord-294854-rvrgcugn 53 21 new new JJ cord-294854-rvrgcugn 53 22 results result NNS cord-294854-rvrgcugn 53 23 may may MD cord-294854-rvrgcugn 53 24 be be VB cord-294854-rvrgcugn 53 25 produced produce VBN cord-294854-rvrgcugn 53 26 as as IN cord-294854-rvrgcugn 53 27 more more JJR cord-294854-rvrgcugn 53 28 data datum NNS cord-294854-rvrgcugn 53 29 become become VBP cord-294854-rvrgcugn 53 30 available available JJ cord-294854-rvrgcugn 53 31 . . . cord-294854-rvrgcugn 54 1 The the DT cord-294854-rvrgcugn 54 2 emergence emergence NN cord-294854-rvrgcugn 54 3 of of IN cord-294854-rvrgcugn 54 4 variants variant NNS cord-294854-rvrgcugn 54 5 may may MD cord-294854-rvrgcugn 54 6 add add VB cord-294854-rvrgcugn 54 7 to to IN cord-294854-rvrgcugn 54 8 the the DT cord-294854-rvrgcugn 54 9 challenges challenge NNS cord-294854-rvrgcugn 54 10 of of IN cord-294854-rvrgcugn 54 11 vaccine vaccine NN cord-294854-rvrgcugn 54 12 development development NN cord-294854-rvrgcugn 54 13 . . . cord-294854-rvrgcugn 55 1 Pathological pathological JJ cord-294854-rvrgcugn 55 2 alterations alteration NNS cord-294854-rvrgcugn 55 3 in in IN cord-294854-rvrgcugn 55 4 COVID-19 covid-19 JJ cord-294854-rvrgcugn 55 5 patients patient NNS cord-294854-rvrgcugn 55 6 include include VBP cord-294854-rvrgcugn 55 7 pulmonary pulmonary JJ cord-294854-rvrgcugn 55 8 edema edema NN cord-294854-rvrgcugn 55 9 , , , cord-294854-rvrgcugn 55 10 diffuse diffuse VB cord-294854-rvrgcugn 55 11 alveolar alveolar NN cord-294854-rvrgcugn 55 12 injury injury NN cord-294854-rvrgcugn 55 13 with with IN cord-294854-rvrgcugn 55 14 the the DT cord-294854-rvrgcugn 55 15 formation formation NN cord-294854-rvrgcugn 55 16 of of IN cord-294854-rvrgcugn 55 17 hyaline hyaline JJ cord-294854-rvrgcugn 55 18 membranes membrane NNS cord-294854-rvrgcugn 55 19 , , , cord-294854-rvrgcugn 55 20 the the DT cord-294854-rvrgcugn 55 21 presence presence NN cord-294854-rvrgcugn 55 22 of of IN cord-294854-rvrgcugn 55 23 reactive reactive JJ cord-294854-rvrgcugn 55 24 type type NN cord-294854-rvrgcugn 55 25 II II NNP cord-294854-rvrgcugn 55 26 pneumocyte pneumocyte NNP cord-294854-rvrgcugn 55 27 hyperplasia hyperplasia NN cord-294854-rvrgcugn 55 28 , , , cord-294854-rvrgcugn 55 29 proteinaceous proteinaceous JJ cord-294854-rvrgcugn 55 30 aggregates aggregate NNS cord-294854-rvrgcugn 55 31 , , , cord-294854-rvrgcugn 55 32 fibrinous fibrinous NNP cord-294854-rvrgcugn 55 33 Accepted Accepted NNP cord-294854-rvrgcugn 55 34 Article Article NNP cord-294854-rvrgcugn 55 35 exudates exudate NNS cord-294854-rvrgcugn 55 36 , , , cord-294854-rvrgcugn 55 37 monocytes monocyte NNS cord-294854-rvrgcugn 55 38 and and CC cord-294854-rvrgcugn 55 39 macrophages macrophage NNS cord-294854-rvrgcugn 55 40 within within IN cord-294854-rvrgcugn 55 41 alveolar alveolar JJ cord-294854-rvrgcugn 55 42 spaces space NNS cord-294854-rvrgcugn 55 43 , , , cord-294854-rvrgcugn 55 44 and and CC cord-294854-rvrgcugn 55 45 inflammatory inflammatory JJ cord-294854-rvrgcugn 55 46 infiltration infiltration NN cord-294854-rvrgcugn 55 47 of of IN cord-294854-rvrgcugn 55 48 interstitial interstitial JJ cord-294854-rvrgcugn 55 49 mononuclear mononuclear NN cord-294854-rvrgcugn 55 50 cells cell NNS cord-294854-rvrgcugn 55 51 [ [ -LRB- cord-294854-rvrgcugn 55 52 25 25 CD cord-294854-rvrgcugn 55 53 ] ] -RRB- cord-294854-rvrgcugn 55 54 [ [ -LRB- cord-294854-rvrgcugn 55 55 26 26 CD cord-294854-rvrgcugn 55 56 ] ] -RRB- cord-294854-rvrgcugn 55 57 [ [ -LRB- cord-294854-rvrgcugn 55 58 27 27 CD cord-294854-rvrgcugn 55 59 ] ] -RRB- cord-294854-rvrgcugn 55 60 [ [ -LRB- cord-294854-rvrgcugn 55 61 28 28 CD cord-294854-rvrgcugn 55 62 ] ] -RRB- cord-294854-rvrgcugn 55 63 . . . cord-294854-rvrgcugn 56 1 Electron electron NN cord-294854-rvrgcugn 56 2 microscopy microscopy NN cord-294854-rvrgcugn 56 3 has have VBZ cord-294854-rvrgcugn 56 4 revealed reveal VBN cord-294854-rvrgcugn 56 5 the the DT cord-294854-rvrgcugn 56 6 presence presence NN cord-294854-rvrgcugn 56 7 of of IN cord-294854-rvrgcugn 56 8 SARS SARS NNP cord-294854-rvrgcugn 56 9 - - HYPH cord-294854-rvrgcugn 56 10 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 56 11 virus virus NN cord-294854-rvrgcugn 56 12 particles particle NNS cord-294854-rvrgcugn 56 13 in in IN cord-294854-rvrgcugn 56 14 bronchial bronchial JJ cord-294854-rvrgcugn 56 15 and and CC cord-294854-rvrgcugn 56 16 alveolar alveolar JJ cord-294854-rvrgcugn 56 17 type type NN cord-294854-rvrgcugn 56 18 II ii CD cord-294854-rvrgcugn 56 19 epithelial epithelial JJ cord-294854-rvrgcugn 56 20 cells cell NNS cord-294854-rvrgcugn 56 21 , , , cord-294854-rvrgcugn 56 22 but but CC cord-294854-rvrgcugn 56 23 not not RB cord-294854-rvrgcugn 56 24 in in IN cord-294854-rvrgcugn 56 25 other other JJ cord-294854-rvrgcugn 56 26 tissues tissue NNS cord-294854-rvrgcugn 56 27 26 26 CD cord-294854-rvrgcugn 56 28 , , , cord-294854-rvrgcugn 56 29 27 27 CD cord-294854-rvrgcugn 56 30 . . . cord-294854-rvrgcugn 57 1 Therefore therefore RB cord-294854-rvrgcugn 57 2 , , , cord-294854-rvrgcugn 57 3 although although IN cord-294854-rvrgcugn 57 4 a a DT cord-294854-rvrgcugn 57 5 PCR PCR NNP cord-294854-rvrgcugn 57 6 test test NN cord-294854-rvrgcugn 57 7 may may MD cord-294854-rvrgcugn 57 8 be be VB cord-294854-rvrgcugn 57 9 negative negative JJ cord-294854-rvrgcugn 57 10 from from IN cord-294854-rvrgcugn 57 11 blood blood NN cord-294854-rvrgcugn 57 12 or or CC cord-294854-rvrgcugn 57 13 throat throat NN cord-294854-rvrgcugn 57 14 swabs swab NNS cord-294854-rvrgcugn 57 15 , , , cord-294854-rvrgcugn 57 16 SARS SARS NNP cord-294854-rvrgcugn 57 17 - - HYPH cord-294854-rvrgcugn 57 18 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 57 19 viral viral JJ cord-294854-rvrgcugn 57 20 inclusions inclusion NNS cord-294854-rvrgcugn 57 21 may may MD cord-294854-rvrgcugn 57 22 be be VB cord-294854-rvrgcugn 57 23 detected detect VBN cord-294854-rvrgcugn 57 24 in in IN cord-294854-rvrgcugn 57 25 the the DT cord-294854-rvrgcugn 57 26 lungs lung NNS cord-294854-rvrgcugn 57 27 . . . cord-294854-rvrgcugn 58 1 Immunohistochemical immunohistochemical JJ cord-294854-rvrgcugn 58 2 staining staining NN cord-294854-rvrgcugn 58 3 indicated indicate VBD cord-294854-rvrgcugn 58 4 that that IN cord-294854-rvrgcugn 58 5 CD68 CD68 NNS cord-294854-rvrgcugn 58 6 + + CC cord-294854-rvrgcugn 58 7 macrophages macrophage NNS cord-294854-rvrgcugn 58 8 , , , cord-294854-rvrgcugn 58 9 CD20 cd20 NN cord-294854-rvrgcugn 58 10 + + CC cord-294854-rvrgcugn 58 11 B b NN cord-294854-rvrgcugn 58 12 cells cell NNS cord-294854-rvrgcugn 58 13 , , , cord-294854-rvrgcugn 58 14 and and CC cord-294854-rvrgcugn 58 15 CD8 CD8 NNP cord-294854-rvrgcugn 58 16 + + CC cord-294854-rvrgcugn 58 17 T T NNP cord-294854-rvrgcugn 58 18 cells cell NNS cord-294854-rvrgcugn 58 19 infiltrated infiltrate VBD cord-294854-rvrgcugn 58 20 the the DT cord-294854-rvrgcugn 58 21 alveolar alveolar NN cord-294854-rvrgcugn 58 22 cavity cavity NN cord-294854-rvrgcugn 58 23 and and CC cord-294854-rvrgcugn 58 24 alveoli alveolus NNS cord-294854-rvrgcugn 58 25 26 26 CD cord-294854-rvrgcugn 58 26 . . . cord-294854-rvrgcugn 59 1 The the DT cord-294854-rvrgcugn 59 2 levels level NNS cord-294854-rvrgcugn 59 3 of of IN cord-294854-rvrgcugn 59 4 CD8 CD8 NNP cord-294854-rvrgcugn 59 5 + + NNP cord-294854-rvrgcugn 59 6 T T NNP cord-294854-rvrgcugn 59 7 cells cell NNS cord-294854-rvrgcugn 59 8 may may MD cord-294854-rvrgcugn 59 9 be be VB cord-294854-rvrgcugn 59 10 slightly slightly RB cord-294854-rvrgcugn 59 11 higher high JJR cord-294854-rvrgcugn 59 12 than than IN cord-294854-rvrgcugn 59 13 that that DT cord-294854-rvrgcugn 59 14 of of IN cord-294854-rvrgcugn 59 15 CD4 CD4 NNP cord-294854-rvrgcugn 59 16 + + NNP cord-294854-rvrgcugn 59 17 T T NNP cord-294854-rvrgcugn 59 18 cells cell NNS cord-294854-rvrgcugn 59 19 within within IN cord-294854-rvrgcugn 59 20 the the DT cord-294854-rvrgcugn 59 21 alveolar alveolar JJ cord-294854-rvrgcugn 59 22 septa septa NNP cord-294854-rvrgcugn 59 23 29 29 CD cord-294854-rvrgcugn 59 24 _SP cord-294854-rvrgcugn 59 25 Cellular Cellular NNP cord-294854-rvrgcugn 59 26 entry entry NN cord-294854-rvrgcugn 59 27 of of IN cord-294854-rvrgcugn 59 28 SARS SARS NNP cord-294854-rvrgcugn 59 29 - - HYPH cord-294854-rvrgcugn 59 30 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 59 31 depends depend VBZ cord-294854-rvrgcugn 59 32 on on IN cord-294854-rvrgcugn 59 33 the the DT cord-294854-rvrgcugn 59 34 binding binding NN cord-294854-rvrgcugn 59 35 of of IN cord-294854-rvrgcugn 59 36 S S NNP cord-294854-rvrgcugn 59 37 proteins protein NNS cord-294854-rvrgcugn 59 38 covering cover VBG cord-294854-rvrgcugn 59 39 the the DT cord-294854-rvrgcugn 59 40 surface surface NN cord-294854-rvrgcugn 59 41 of of IN cord-294854-rvrgcugn 59 42 the the DT cord-294854-rvrgcugn 59 43 virion virion NN cord-294854-rvrgcugn 59 44 to to IN cord-294854-rvrgcugn 59 45 the the DT cord-294854-rvrgcugn 59 46 cellular cellular JJ cord-294854-rvrgcugn 59 47 ACE2 ACE2 NNP cord-294854-rvrgcugn 59 48 receptor receptor NN cord-294854-rvrgcugn 59 49 9 9 CD cord-294854-rvrgcugn 59 50 , , , cord-294854-rvrgcugn 59 51 33 33 CD cord-294854-rvrgcugn 59 52 and and CC cord-294854-rvrgcugn 59 53 on on IN cord-294854-rvrgcugn 59 54 S s NN cord-294854-rvrgcugn 59 55 protein protein NN cord-294854-rvrgcugn 60 1 This this DT cord-294854-rvrgcugn 60 2 article article NN cord-294854-rvrgcugn 60 3 is be VBZ cord-294854-rvrgcugn 60 4 protected protect VBN cord-294854-rvrgcugn 60 5 by by IN cord-294854-rvrgcugn 60 6 copyright copyright NN cord-294854-rvrgcugn 60 7 . . . cord-294854-rvrgcugn 61 1 All all DT cord-294854-rvrgcugn 61 2 rights right NNS cord-294854-rvrgcugn 61 3 reserved reserve VBN cord-294854-rvrgcugn 61 4 . . . cord-294854-rvrgcugn 62 1 priming prime VBG cord-294854-rvrgcugn 62 2 by by IN cord-294854-rvrgcugn 62 3 TMPRSS2 TMPRSS2 NNP cord-294854-rvrgcugn 62 4 , , , cord-294854-rvrgcugn 62 5 a a DT cord-294854-rvrgcugn 62 6 host host NN cord-294854-rvrgcugn 62 7 membrane membrane NN cord-294854-rvrgcugn 62 8 serine serine NN cord-294854-rvrgcugn 62 9 protease protease NN cord-294854-rvrgcugn 62 10 33 33 CD cord-294854-rvrgcugn 62 11 Table table NN cord-294854-rvrgcugn 62 12 1 1 CD cord-294854-rvrgcugn 62 13 , , , cord-294854-rvrgcugn 62 14 and and CC cord-294854-rvrgcugn 62 15 cytokine cytokine JJ cord-294854-rvrgcugn 62 16 secretion secretion NN cord-294854-rvrgcugn 62 17 patterns pattern NNS cord-294854-rvrgcugn 62 18 based base VBN cord-294854-rvrgcugn 62 19 on on IN cord-294854-rvrgcugn 62 20 COVID-19 covid-19 JJ cord-294854-rvrgcugn 62 21 severity severity NN cord-294854-rvrgcugn 62 22 are be VBP cord-294854-rvrgcugn 62 23 shown show VBN cord-294854-rvrgcugn 62 24 in in IN cord-294854-rvrgcugn 62 25 Table Table NNP cord-294854-rvrgcugn 62 26 2 2 CD cord-294854-rvrgcugn 62 27 . . . cord-294854-rvrgcugn 63 1 Prevention prevention NN cord-294854-rvrgcugn 63 2 and and CC cord-294854-rvrgcugn 63 3 mitigation mitigation NN cord-294854-rvrgcugn 63 4 of of IN cord-294854-rvrgcugn 63 5 the the DT cord-294854-rvrgcugn 63 6 cytokine cytokine NN cord-294854-rvrgcugn 63 7 storm storm NN cord-294854-rvrgcugn 63 8 may may MD cord-294854-rvrgcugn 63 9 be be VB cord-294854-rvrgcugn 63 10 the the DT cord-294854-rvrgcugn 63 11 crux crux NN cord-294854-rvrgcugn 63 12 to to IN cord-294854-rvrgcugn 63 13 saving save VBG cord-294854-rvrgcugn 63 14 patients patient NNS cord-294854-rvrgcugn 63 15 with with IN cord-294854-rvrgcugn 63 16 severe severe JJ cord-294854-rvrgcugn 63 17 COVID-19 covid-19 NN cord-294854-rvrgcugn 63 18 . . . cord-294854-rvrgcugn 64 1 Currently currently RB cord-294854-rvrgcugn 64 2 , , , cord-294854-rvrgcugn 64 3 many many JJ cord-294854-rvrgcugn 64 4 therapies therapy NNS cord-294854-rvrgcugn 64 5 are be VBP cord-294854-rvrgcugn 64 6 being be VBG cord-294854-rvrgcugn 64 7 evaluated evaluate VBN cord-294854-rvrgcugn 64 8 in in IN cord-294854-rvrgcugn 64 9 clinical clinical JJ cord-294854-rvrgcugn 64 10 trials trial NNS cord-294854-rvrgcugn 64 11 due due JJ cord-294854-rvrgcugn 64 12 to to IN cord-294854-rvrgcugn 64 13 a a DT cord-294854-rvrgcugn 64 14 lack lack NN cord-294854-rvrgcugn 64 15 of of IN cord-294854-rvrgcugn 64 16 high high JJ cord-294854-rvrgcugn 64 17 - - HYPH cord-294854-rvrgcugn 64 18 quality quality NN cord-294854-rvrgcugn 64 19 evidence evidence NN cord-294854-rvrgcugn 64 20 . . . cord-294854-rvrgcugn 65 1 Corticosteroids corticosteroid NNS cord-294854-rvrgcugn 65 2 inhibit inhibit VBP cord-294854-rvrgcugn 65 3 the the DT cord-294854-rvrgcugn 65 4 host host NN cord-294854-rvrgcugn 65 5 inflammatory inflammatory JJ cord-294854-rvrgcugn 65 6 response response NN cord-294854-rvrgcugn 65 7 and and CC cord-294854-rvrgcugn 65 8 suppress suppress VB cord-294854-rvrgcugn 65 9 the the DT cord-294854-rvrgcugn 65 10 immune immune JJ cord-294854-rvrgcugn 65 11 response response NN cord-294854-rvrgcugn 65 12 and and CC cord-294854-rvrgcugn 65 13 pathogen pathogen NN cord-294854-rvrgcugn 65 14 clearance clearance NN cord-294854-rvrgcugn 65 15 46 46 CD cord-294854-rvrgcugn 66 1 Overall overall RB cord-294854-rvrgcugn 66 2 , , , cord-294854-rvrgcugn 66 3 although although IN cord-294854-rvrgcugn 66 4 evidence evidence NN cord-294854-rvrgcugn 66 5 indicates indicate VBZ cord-294854-rvrgcugn 66 6 a a DT cord-294854-rvrgcugn 66 7 potential potential JJ cord-294854-rvrgcugn 66 8 role role NN cord-294854-rvrgcugn 66 9 for for IN cord-294854-rvrgcugn 66 10 the the DT cord-294854-rvrgcugn 66 11 use use NN cord-294854-rvrgcugn 66 12 of of IN cord-294854-rvrgcugn 66 13 corticosteroids corticosteroid NNS cord-294854-rvrgcugn 66 14 This this DT cord-294854-rvrgcugn 66 15 article article NN cord-294854-rvrgcugn 66 16 is be VBZ cord-294854-rvrgcugn 66 17 protected protect VBN cord-294854-rvrgcugn 66 18 by by IN cord-294854-rvrgcugn 66 19 copyright copyright NN cord-294854-rvrgcugn 66 20 . . . cord-294854-rvrgcugn 67 1 All all DT cord-294854-rvrgcugn 67 2 rights right NNS cord-294854-rvrgcugn 67 3 reserved reserve VBN cord-294854-rvrgcugn 67 4 . . . cord-294854-rvrgcugn 68 1 in in IN cord-294854-rvrgcugn 68 2 patients patient NNS cord-294854-rvrgcugn 68 3 with with IN cord-294854-rvrgcugn 68 4 severe severe JJ cord-294854-rvrgcugn 68 5 COVID-19 covid-19 NN cord-294854-rvrgcugn 68 6 , , , cord-294854-rvrgcugn 68 7 caution caution NN cord-294854-rvrgcugn 68 8 should should MD cord-294854-rvrgcugn 68 9 be be VB cord-294854-rvrgcugn 68 10 exercised exercise VBN cord-294854-rvrgcugn 68 11 given give VBN cord-294854-rvrgcugn 68 12 the the DT cord-294854-rvrgcugn 68 13 possibilities possibility NNS cord-294854-rvrgcugn 68 14 of of IN cord-294854-rvrgcugn 68 15 viral viral JJ cord-294854-rvrgcugn 68 16 rebound rebound NN cord-294854-rvrgcugn 68 17 and and CC cord-294854-rvrgcugn 68 18 adverse adverse JJ cord-294854-rvrgcugn 68 19 events event NNS cord-294854-rvrgcugn 68 20 . . . cord-294854-rvrgcugn 69 1 Given give VBN cord-294854-rvrgcugn 69 2 their -PRON- PRP$ cord-294854-rvrgcugn 69 3 in in IN cord-294854-rvrgcugn 69 4 vitro vitro FW cord-294854-rvrgcugn 69 5 antiviral antiviral JJ cord-294854-rvrgcugn 69 6 effects effect NNS cord-294854-rvrgcugn 69 7 and and CC cord-294854-rvrgcugn 69 8 anti anti JJ cord-294854-rvrgcugn 69 9 - - JJ cord-294854-rvrgcugn 69 10 inflammatory inflammatory JJ cord-294854-rvrgcugn 69 11 properties property NNS cord-294854-rvrgcugn 69 12 , , , cord-294854-rvrgcugn 69 13 CQ CQ NNP cord-294854-rvrgcugn 69 14 and and CC cord-294854-rvrgcugn 69 15 its -PRON- PRP$ cord-294854-rvrgcugn 69 16 analog analog JJ cord-294854-rvrgcugn 69 17 HCQ HCQ NNP cord-294854-rvrgcugn 69 18 are be VBP cord-294854-rvrgcugn 69 19 considered consider VBN cord-294854-rvrgcugn 69 20 to to TO cord-294854-rvrgcugn 69 21 be be VB cord-294854-rvrgcugn 69 22 potential potential JJ cord-294854-rvrgcugn 69 23 therapies therapy NNS cord-294854-rvrgcugn 69 24 for for IN cord-294854-rvrgcugn 69 25 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 69 26 . . . cord-294854-rvrgcugn 70 1 Considering consider VBG cord-294854-rvrgcugn 70 2 the the DT cord-294854-rvrgcugn 70 3 severe severe JJ cord-294854-rvrgcugn 70 4 side side NN cord-294854-rvrgcugn 70 5 effects effect NNS cord-294854-rvrgcugn 70 6 of of IN cord-294854-rvrgcugn 70 7 CQ CQ NNP cord-294854-rvrgcugn 70 8 , , , cord-294854-rvrgcugn 70 9 HCQ HCQ NNP cord-294854-rvrgcugn 70 10 may may MD cord-294854-rvrgcugn 70 11 be be VB cord-294854-rvrgcugn 70 12 a a DT cord-294854-rvrgcugn 70 13 better well RBR cord-294854-rvrgcugn 70 14 therapeutic therapeutic JJ cord-294854-rvrgcugn 70 15 option option NN cord-294854-rvrgcugn 70 16 . . . cord-294854-rvrgcugn 71 1 CQ CQ NNP cord-294854-rvrgcugn 71 2 and and CC cord-294854-rvrgcugn 71 3 HCQ HCQ NNP cord-294854-rvrgcugn 71 4 are be VBP cord-294854-rvrgcugn 71 5 able able JJ cord-294854-rvrgcugn 71 6 to to TO cord-294854-rvrgcugn 71 7 reduce reduce VB cord-294854-rvrgcugn 71 8 CD154 cd154 CD cord-294854-rvrgcugn 71 9 expression expression NN cord-294854-rvrgcugn 71 10 in in IN cord-294854-rvrgcugn 71 11 T T NNP cord-294854-rvrgcugn 71 12 cells cell NNS cord-294854-rvrgcugn 71 13 52 52 CD cord-294854-rvrgcugn 72 1 However however RB cord-294854-rvrgcugn 72 2 , , , cord-294854-rvrgcugn 72 3 the the DT cord-294854-rvrgcugn 72 4 risks risk NNS cord-294854-rvrgcugn 72 5 associated associate VBN cord-294854-rvrgcugn 72 6 with with IN cord-294854-rvrgcugn 72 7 TCZ tcz NN cord-294854-rvrgcugn 72 8 ( ( -LRB- cord-294854-rvrgcugn 72 9 e.g. e.g. RB cord-294854-rvrgcugn 72 10 , , , cord-294854-rvrgcugn 72 11 severe severe JJ cord-294854-rvrgcugn 72 12 infections infection NNS cord-294854-rvrgcugn 72 13 , , , cord-294854-rvrgcugn 72 14 thrombocytopenia thrombocytopenia NN cord-294854-rvrgcugn 72 15 , , , cord-294854-rvrgcugn 72 16 neutropenia neutropenia NN cord-294854-rvrgcugn 72 17 , , , cord-294854-rvrgcugn 72 18 liver liver NN cord-294854-rvrgcugn 72 19 damage damage NN cord-294854-rvrgcugn 72 20 ) ) -RRB- cord-294854-rvrgcugn 72 21 should should MD cord-294854-rvrgcugn 72 22 also also RB cord-294854-rvrgcugn 72 23 be be VB cord-294854-rvrgcugn 72 24 noted note VBN cord-294854-rvrgcugn 72 25 64 64 CD cord-294854-rvrgcugn 72 26 . . . cord-294854-rvrgcugn 73 1 It -PRON- PRP cord-294854-rvrgcugn 73 2 is be VBZ cord-294854-rvrgcugn 73 3 unclear unclear JJ cord-294854-rvrgcugn 73 4 whether whether IN cord-294854-rvrgcugn 73 5 there there EX cord-294854-rvrgcugn 73 6 are be VBP cord-294854-rvrgcugn 73 7 different different JJ cord-294854-rvrgcugn 73 8 effects effect NNS cord-294854-rvrgcugn 73 9 between between IN cord-294854-rvrgcugn 73 10 IL-6 IL-6 NNP cord-294854-rvrgcugn 73 11 antagonists antagonist NNS cord-294854-rvrgcugn 73 12 ( ( -LRB- cord-294854-rvrgcugn 73 13 siltuximab siltuximab NNP cord-294854-rvrgcugn 73 14 ) ) -RRB- cord-294854-rvrgcugn 73 15 and and CC cord-294854-rvrgcugn 73 16 IL-6R IL-6R NNP cord-294854-rvrgcugn 73 17 antagonists antagonist NNS cord-294854-rvrgcugn 73 18 ( ( -LRB- cord-294854-rvrgcugn 73 19 TCZ TCZ NNP cord-294854-rvrgcugn 73 20 ) ) -RRB- cord-294854-rvrgcugn 73 21 . . . cord-294854-rvrgcugn 74 1 Siltuximab Siltuximab NNP cord-294854-rvrgcugn 74 2 binds bind VBZ cord-294854-rvrgcugn 74 3 to to IN cord-294854-rvrgcugn 74 4 sIL-6 sIL-6 NNP cord-294854-rvrgcugn 74 5 and and CC cord-294854-rvrgcugn 74 6 inhibits inhibit VBZ cord-294854-rvrgcugn 74 7 only only RB cord-294854-rvrgcugn 74 8 cis cis NNP cord-294854-rvrgcugn 74 9 and and CC cord-294854-rvrgcugn 74 10 trans trans NNP cord-294854-rvrgcugn 74 11 signaling signal VBG cord-294854-rvrgcugn 74 12 . . . cord-294854-rvrgcugn 75 1 TCZ tcz NN cord-294854-rvrgcugn 75 2 binds bind VBZ cord-294854-rvrgcugn 75 3 to to IN cord-294854-rvrgcugn 75 4 both both DT cord-294854-rvrgcugn 75 5 mIL-6R mIL-6R NNP cord-294854-rvrgcugn 75 6 and and CC cord-294854-rvrgcugn 75 7 sIL-6R sIL-6R NNP cord-294854-rvrgcugn 75 8 and and CC cord-294854-rvrgcugn 75 9 inhibits inhibit VBZ cord-294854-rvrgcugn 75 10 both both DT cord-294854-rvrgcugn 75 11 cis cis NNP cord-294854-rvrgcugn 75 12 and and CC cord-294854-rvrgcugn 75 13 trans trans NNP cord-294854-rvrgcugn 75 14 signaling signal VBG cord-294854-rvrgcugn 75 15 and and CC cord-294854-rvrgcugn 75 16 trans trans NNP cord-294854-rvrgcugn 75 17 presentation presentation NN cord-294854-rvrgcugn 75 18 40 40 CD cord-294854-rvrgcugn 75 19 , , , cord-294854-rvrgcugn 75 20 65 65 CD cord-294854-rvrgcugn 75 21 . . . cord-294854-rvrgcugn 76 1 Of of IN cord-294854-rvrgcugn 76 2 note note NN cord-294854-rvrgcugn 76 3 , , , cord-294854-rvrgcugn 76 4 IL-6 IL-6 NNP cord-294854-rvrgcugn 76 5 inhibitors inhibitor NNS cord-294854-rvrgcugn 76 6 are be VBP cord-294854-rvrgcugn 76 7 not not RB cord-294854-rvrgcugn 76 8 able able JJ cord-294854-rvrgcugn 76 9 to to TO cord-294854-rvrgcugn 76 10 bind bind VB cord-294854-rvrgcugn 76 11 to to IN cord-294854-rvrgcugn 76 12 IL-6 IL-6 NNP cord-294854-rvrgcugn 76 13 produced produce VBN cord-294854-rvrgcugn 76 14 by by IN cord-294854-rvrgcugn 76 15 viruses virus NNS cord-294854-rvrgcugn 76 16 such such JJ cord-294854-rvrgcugn 76 17 as as IN cord-294854-rvrgcugn 76 18 HIV HIV NNP cord-294854-rvrgcugn 76 19 and and CC cord-294854-rvrgcugn 76 20 human human JJ cord-294854-rvrgcugn 76 21 herpesvirus-8 herpesvirus-8 NNP cord-294854-rvrgcugn 76 22 65 65 CD cord-294854-rvrgcugn 76 23 . . . cord-294854-rvrgcugn 77 1 Currently currently RB cord-294854-rvrgcugn 77 2 , , , cord-294854-rvrgcugn 77 3 the the DT cord-294854-rvrgcugn 77 4 application application NN cord-294854-rvrgcugn 77 5 of of IN cord-294854-rvrgcugn 77 6 TCZ TCZ NNP cord-294854-rvrgcugn 77 7 for for IN cord-294854-rvrgcugn 77 8 COVID-19 covid-19 JJ cord-294854-rvrgcugn 77 9 treatment treatment NN cord-294854-rvrgcugn 77 10 is be VBZ cord-294854-rvrgcugn 77 11 under under IN cord-294854-rvrgcugn 77 12 study study NN cord-294854-rvrgcugn 77 13 . . . cord-294854-rvrgcugn 78 1 The the DT cord-294854-rvrgcugn 78 2 three three CD cord-294854-rvrgcugn 78 3 drugs drug NNS cord-294854-rvrgcugn 78 4 mentioned mention VBN cord-294854-rvrgcugn 78 5 above above RB cord-294854-rvrgcugn 78 6 ( ( -LRB- cord-294854-rvrgcugn 78 7 corticosteroids corticosteroid NNS cord-294854-rvrgcugn 78 8 , , , cord-294854-rvrgcugn 78 9 HCQ HCQ NNP cord-294854-rvrgcugn 78 10 , , , cord-294854-rvrgcugn 78 11 TCZ TCZ NNP cord-294854-rvrgcugn 78 12 ) ) -RRB- cord-294854-rvrgcugn 78 13 are be VBP cord-294854-rvrgcugn 78 14 immunosuppressants immunosuppressant NNS cord-294854-rvrgcugn 78 15 . . . cord-294854-rvrgcugn 79 1 Owing owe VBG cord-294854-rvrgcugn 79 2 to to IN cord-294854-rvrgcugn 79 3 overall overall JJ cord-294854-rvrgcugn 79 4 damage damage NN cord-294854-rvrgcugn 79 5 to to IN cord-294854-rvrgcugn 79 6 the the DT cord-294854-rvrgcugn 79 7 immune immune JJ cord-294854-rvrgcugn 79 8 system system NN cord-294854-rvrgcugn 79 9 caused cause VBN cord-294854-rvrgcugn 79 10 by by IN cord-294854-rvrgcugn 79 11 autoimmune autoimmune JJ cord-294854-rvrgcugn 79 12 diseases disease NNS cord-294854-rvrgcugn 79 13 and and CC cord-294854-rvrgcugn 79 14 the the DT cord-294854-rvrgcugn 79 15 iatrogenic iatrogenic JJ cord-294854-rvrgcugn 79 16 effects effect NNS cord-294854-rvrgcugn 79 17 of of IN cord-294854-rvrgcugn 79 18 immunosuppressants immunosuppressant NNS cord-294854-rvrgcugn 79 19 , , , cord-294854-rvrgcugn 79 20 the the DT cord-294854-rvrgcugn 79 21 risk risk NN cord-294854-rvrgcugn 79 22 of of IN cord-294854-rvrgcugn 79 23 infection infection NN cord-294854-rvrgcugn 79 24 in in IN cord-294854-rvrgcugn 79 25 patients patient NNS cord-294854-rvrgcugn 79 26 with with IN cord-294854-rvrgcugn 79 27 autoimmune autoimmune JJ cord-294854-rvrgcugn 79 28 diseases disease NNS cord-294854-rvrgcugn 79 29 will will MD cord-294854-rvrgcugn 79 30 be be VB cord-294854-rvrgcugn 79 31 increased increase VBN cord-294854-rvrgcugn 79 32 compared compare VBN cord-294854-rvrgcugn 79 33 to to IN cord-294854-rvrgcugn 79 34 the the DT cord-294854-rvrgcugn 79 35 general general JJ cord-294854-rvrgcugn 79 36 population population NN cord-294854-rvrgcugn 79 37 . . . cord-294854-rvrgcugn 80 1 Currently currently RB cord-294854-rvrgcugn 80 2 , , , cord-294854-rvrgcugn 80 3 rheumatology rheumatology NN cord-294854-rvrgcugn 80 4 societies society NNS cord-294854-rvrgcugn 80 5 66 66 CD cord-294854-rvrgcugn 80 6 - - SYM cord-294854-rvrgcugn 80 7 69 69 CD cord-294854-rvrgcugn 80 8 recommend recommend VBP cord-294854-rvrgcugn 80 9 the the DT cord-294854-rvrgcugn 80 10 use use NN cord-294854-rvrgcugn 80 11 of of IN cord-294854-rvrgcugn 80 12 immunosuppressive immunosuppressive JJ cord-294854-rvrgcugn 80 13 drugs drug NNS cord-294854-rvrgcugn 80 14 ( ( -LRB- cord-294854-rvrgcugn 80 15 except except IN cord-294854-rvrgcugn 80 16 glucocorticoids glucocorticoid NNS cord-294854-rvrgcugn 80 17 ) ) -RRB- cord-294854-rvrgcugn 80 18 to to TO cord-294854-rvrgcugn 80 19 be be VB cord-294854-rvrgcugn 80 20 suspended suspend VBN cord-294854-rvrgcugn 80 21 in in IN cord-294854-rvrgcugn 80 22 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 80 23 patients patient NNS cord-294854-rvrgcugn 80 24 . . . cord-294854-rvrgcugn 81 1 MSCs msc NNS cord-294854-rvrgcugn 81 2 have have VBP cord-294854-rvrgcugn 81 3 a a DT cord-294854-rvrgcugn 81 4 wide wide JJ cord-294854-rvrgcugn 81 5 range range NN cord-294854-rvrgcugn 81 6 of of IN cord-294854-rvrgcugn 81 7 immune immune JJ cord-294854-rvrgcugn 81 8 regulatory regulatory JJ cord-294854-rvrgcugn 81 9 functions function NNS cord-294854-rvrgcugn 81 10 and and CC cord-294854-rvrgcugn 81 11 can can MD cord-294854-rvrgcugn 81 12 inhibit inhibit VB cord-294854-rvrgcugn 81 13 the the DT cord-294854-rvrgcugn 81 14 abnormal abnormal JJ cord-294854-rvrgcugn 81 15 activation activation NN cord-294854-rvrgcugn 81 16 of of IN cord-294854-rvrgcugn 81 17 T T NNP cord-294854-rvrgcugn 81 18 lymphocytes lymphocyte NNS cord-294854-rvrgcugn 81 19 and and CC cord-294854-rvrgcugn 81 20 macrophages macrophage NNS cord-294854-rvrgcugn 81 21 and and CC cord-294854-rvrgcugn 81 22 the the DT cord-294854-rvrgcugn 81 23 secretion secretion NN cord-294854-rvrgcugn 81 24 of of IN cord-294854-rvrgcugn 81 25 pro pro JJ cord-294854-rvrgcugn 81 26 - - JJ cord-294854-rvrgcugn 81 27 inflammatory inflammatory JJ cord-294854-rvrgcugn 81 28 cytokines cytokine NNS cord-294854-rvrgcugn 81 29 70 70 CD cord-294854-rvrgcugn 81 30 . . . cord-294854-rvrgcugn 82 1 MSC MSC NNP cord-294854-rvrgcugn 82 2 therapy therapy NN cord-294854-rvrgcugn 82 3 was be VBD cord-294854-rvrgcugn 82 4 found find VBN cord-294854-rvrgcugn 82 5 to to TO cord-294854-rvrgcugn 82 6 significantly significantly RB cord-294854-rvrgcugn 82 7 reduce reduce VB cord-294854-rvrgcugn 82 8 the the DT cord-294854-rvrgcugn 82 9 mortality mortality NN cord-294854-rvrgcugn 82 10 of of IN cord-294854-rvrgcugn 82 11 patients patient NNS cord-294854-rvrgcugn 82 12 with with IN cord-294854-rvrgcugn 82 13 H7N9-induced H7N9-induced NNP cord-294854-rvrgcugn 82 14 ARDS ARDS NNP cord-294854-rvrgcugn 82 15 and and CC cord-294854-rvrgcugn 82 16 had have VBD cord-294854-rvrgcugn 82 17 no no DT cord-294854-rvrgcugn 82 18 harmful harmful JJ cord-294854-rvrgcugn 82 19 side side NN cord-294854-rvrgcugn 82 20 effects effect NNS cord-294854-rvrgcugn 82 21 71 71 CD cord-294854-rvrgcugn 82 22 . . . cord-294854-rvrgcugn 83 1 A a DT cord-294854-rvrgcugn 83 2 clinical clinical JJ cord-294854-rvrgcugn 83 3 trial trial NN cord-294854-rvrgcugn 83 4 of of IN cord-294854-rvrgcugn 83 5 MSC MSC NNP cord-294854-rvrgcugn 83 6 therapy therapy NN cord-294854-rvrgcugn 83 7 revealed reveal VBD cord-294854-rvrgcugn 83 8 that that IN cord-294854-rvrgcugn 83 9 MSCs msc NNS cord-294854-rvrgcugn 83 10 were be VBD cord-294854-rvrgcugn 83 11 able able JJ cord-294854-rvrgcugn 83 12 to to TO cord-294854-rvrgcugn 83 13 rapidly rapidly RB cord-294854-rvrgcugn 83 14 and and CC cord-294854-rvrgcugn 83 15 significantly significantly RB cord-294854-rvrgcugn 83 16 improve improve VB cord-294854-rvrgcugn 83 17 the the DT cord-294854-rvrgcugn 83 18 clinical clinical JJ cord-294854-rvrgcugn 83 19 symptoms symptom NNS cord-294854-rvrgcugn 83 20 of of IN cord-294854-rvrgcugn 83 21 COVID-19 covid-19 NN cord-294854-rvrgcugn 83 22 without without IN cord-294854-rvrgcugn 83 23 any any DT cord-294854-rvrgcugn 83 24 observed observed JJ cord-294854-rvrgcugn 83 25 adverse adverse JJ cord-294854-rvrgcugn 83 26 effects effect NNS cord-294854-rvrgcugn 83 27 72 72 CD cord-294854-rvrgcugn 83 28 . . . cord-294854-rvrgcugn 84 1 Although although IN cord-294854-rvrgcugn 84 2 side side JJ cord-294854-rvrgcugn 84 3 effects effect NNS cord-294854-rvrgcugn 84 4 of of IN cord-294854-rvrgcugn 84 5 MSC MSC NNP cord-294854-rvrgcugn 84 6 treatment treatment NN cord-294854-rvrgcugn 84 7 are be VBP cord-294854-rvrgcugn 84 8 rarely rarely RB cord-294854-rvrgcugn 84 9 reported report VBN cord-294854-rvrgcugn 84 10 , , , cord-294854-rvrgcugn 84 11 the the DT cord-294854-rvrgcugn 84 12 safety safety NN cord-294854-rvrgcugn 84 13 and and CC cord-294854-rvrgcugn 84 14 effectiveness effectiveness NN cord-294854-rvrgcugn 84 15 of of IN cord-294854-rvrgcugn 84 16 this this DT cord-294854-rvrgcugn 84 17 treatment treatment NN cord-294854-rvrgcugn 84 18 require require VBP cord-294854-rvrgcugn 84 19 further further JJ cord-294854-rvrgcugn 84 20 investigation investigation NN cord-294854-rvrgcugn 84 21 . . . cord-294854-rvrgcugn 85 1 Anakinra Anakinra NNP cord-294854-rvrgcugn 85 2 , , , cord-294854-rvrgcugn 85 3 an an DT cord-294854-rvrgcugn 85 4 IL-1 IL-1 NNP cord-294854-rvrgcugn 85 5 receptor receptor NN cord-294854-rvrgcugn 85 6 antagonist antagonist NN cord-294854-rvrgcugn 85 7 that that WDT cord-294854-rvrgcugn 85 8 blocks block VBZ cord-294854-rvrgcugn 85 9 the the DT cord-294854-rvrgcugn 85 10 activity activity NN cord-294854-rvrgcugn 85 11 of of IN cord-294854-rvrgcugn 85 12 pro pro JJ cord-294854-rvrgcugn 85 13 - - JJ cord-294854-rvrgcugn 85 14 inflammatory inflammatory JJ cord-294854-rvrgcugn 85 15 cytokines cytokine NNS cord-294854-rvrgcugn 85 16 IL-1α il-1α NN cord-294854-rvrgcugn 85 17 and and CC cord-294854-rvrgcugn 85 18 IL-1β IL-1β NNP cord-294854-rvrgcugn 85 19 , , , cord-294854-rvrgcugn 85 20 has have VBZ cord-294854-rvrgcugn 85 21 been be VBN cord-294854-rvrgcugn 85 22 reported report VBN cord-294854-rvrgcugn 85 23 to to TO cord-294854-rvrgcugn 85 24 improve improve VB cord-294854-rvrgcugn 85 25 respiratory respiratory JJ cord-294854-rvrgcugn 85 26 function function NN cord-294854-rvrgcugn 85 27 and and CC cord-294854-rvrgcugn 85 28 increase increase VB cord-294854-rvrgcugn 85 29 the the DT cord-294854-rvrgcugn 85 30 survival survival NN cord-294854-rvrgcugn 85 31 rate rate NN cord-294854-rvrgcugn 85 32 of of IN cord-294854-rvrgcugn 85 33 COVID-19 covid-19 CD cord-294854-rvrgcugn 85 34 patients patient NNS cord-294854-rvrgcugn 85 35 73 73 CD cord-294854-rvrgcugn 85 36 . . . cord-294854-rvrgcugn 86 1 IL-1 IL-1 NNP cord-294854-rvrgcugn 87 1 receptor receptor NN cord-294854-rvrgcugn 87 2 antagonists antagonist NNS cord-294854-rvrgcugn 87 3 increase increase VBP cord-294854-rvrgcugn 87 4 the the DT cord-294854-rvrgcugn 87 5 risk risk NN cord-294854-rvrgcugn 87 6 of of IN cord-294854-rvrgcugn 87 7 bacterial bacterial JJ cord-294854-rvrgcugn 87 8 infections infection NNS cord-294854-rvrgcugn 87 9 , , , cord-294854-rvrgcugn 87 10 but but CC cord-294854-rvrgcugn 87 11 this this DT cord-294854-rvrgcugn 87 12 is be VBZ cord-294854-rvrgcugn 87 13 extremely extremely RB cord-294854-rvrgcugn 87 14 rare rare JJ cord-294854-rvrgcugn 87 15 for for IN cord-294854-rvrgcugn 87 16 anakinra anakinra NNP cord-294854-rvrgcugn 87 17 65 65 CD cord-294854-rvrgcugn 87 18 . . . cord-294854-rvrgcugn 88 1 Janus Janus NNP cord-294854-rvrgcugn 88 2 kinase kinase NN cord-294854-rvrgcugn 88 3 ( ( -LRB- cord-294854-rvrgcugn 88 4 JAK JAK NNP cord-294854-rvrgcugn 88 5 ) ) -RRB- cord-294854-rvrgcugn 88 6 inhibitors inhibitor NNS cord-294854-rvrgcugn 88 7 can can MD cord-294854-rvrgcugn 88 8 inhibit inhibit VB cord-294854-rvrgcugn 88 9 inflammatory inflammatory JJ cord-294854-rvrgcugn 88 10 cytokines cytokine NNS cord-294854-rvrgcugn 88 11 and and CC cord-294854-rvrgcugn 88 12 reduce reduce VB cord-294854-rvrgcugn 88 13 the the DT cord-294854-rvrgcugn 88 14 ability ability NN cord-294854-rvrgcugn 88 15 of of IN cord-294854-rvrgcugn 88 16 viruses virus NNS cord-294854-rvrgcugn 88 17 to to TO cord-294854-rvrgcugn 88 18 infect infect VB cord-294854-rvrgcugn 88 19 cells cell NNS cord-294854-rvrgcugn 88 20 74 74 CD cord-294854-rvrgcugn 88 21 Table table NN cord-294854-rvrgcugn 88 22 3 3 CD cord-294854-rvrgcugn 88 23 . . . cord-294854-rvrgcugn 89 1 The the DT cord-294854-rvrgcugn 89 2 cytokine cytokine NN cord-294854-rvrgcugn 89 3 storm storm NN cord-294854-rvrgcugn 89 4 leads lead VBZ cord-294854-rvrgcugn 89 5 to to IN cord-294854-rvrgcugn 89 6 deleterious deleterious JJ cord-294854-rvrgcugn 89 7 clinical clinical JJ cord-294854-rvrgcugn 89 8 manifestations manifestation NNS cord-294854-rvrgcugn 89 9 or or CC cord-294854-rvrgcugn 89 10 even even RB cord-294854-rvrgcugn 89 11 acute acute JJ cord-294854-rvrgcugn 89 12 mortality mortality NN cord-294854-rvrgcugn 89 13 in in IN cord-294854-rvrgcugn 89 14 critically critically RB cord-294854-rvrgcugn 89 15 ill ill JJ cord-294854-rvrgcugn 89 16 patients patient NNS cord-294854-rvrgcugn 89 17 with with IN cord-294854-rvrgcugn 89 18 COVD-19 COVD-19 NNP cord-294854-rvrgcugn 89 19 . . . cord-294854-rvrgcugn 90 1 Impaired impair VBN cord-294854-rvrgcugn 90 2 acquired acquire VBN cord-294854-rvrgcugn 90 3 immune immune JJ cord-294854-rvrgcugn 91 1 This this DT cord-294854-rvrgcugn 91 2 article article NN cord-294854-rvrgcugn 91 3 is be VBZ cord-294854-rvrgcugn 91 4 protected protect VBN cord-294854-rvrgcugn 91 5 by by IN cord-294854-rvrgcugn 91 6 copyright copyright NN cord-294854-rvrgcugn 91 7 . . . cord-294854-rvrgcugn 92 1 All all DT cord-294854-rvrgcugn 92 2 rights right NNS cord-294854-rvrgcugn 92 3 reserved reserve VBN cord-294854-rvrgcugn 92 4 . . . cord-294854-rvrgcugn 93 1 responses response NNS cord-294854-rvrgcugn 93 2 and and CC cord-294854-rvrgcugn 93 3 uncontrolled uncontrolled JJ cord-294854-rvrgcugn 93 4 inflammatory inflammatory JJ cord-294854-rvrgcugn 93 5 innate innate JJ cord-294854-rvrgcugn 93 6 responses response NNS cord-294854-rvrgcugn 93 7 may may MD cord-294854-rvrgcugn 93 8 be be VB cord-294854-rvrgcugn 93 9 associated associate VBN cord-294854-rvrgcugn 93 10 with with IN cord-294854-rvrgcugn 93 11 the the DT cord-294854-rvrgcugn 93 12 mechanism mechanism NN cord-294854-rvrgcugn 93 13 of of IN cord-294854-rvrgcugn 93 14 the the DT cord-294854-rvrgcugn 93 15 cytokine cytokine NN cord-294854-rvrgcugn 93 16 storm storm NN cord-294854-rvrgcugn 93 17 in in IN cord-294854-rvrgcugn 93 18 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 93 19 . . . cord-294854-rvrgcugn 94 1 Early early JJ cord-294854-rvrgcugn 94 2 control control NN cord-294854-rvrgcugn 94 3 of of IN cord-294854-rvrgcugn 94 4 the the DT cord-294854-rvrgcugn 94 5 cytokine cytokine NN cord-294854-rvrgcugn 94 6 storm storm NN cord-294854-rvrgcugn 94 7 through through IN cord-294854-rvrgcugn 94 8 therapies therapy NNS cord-294854-rvrgcugn 94 9 such such JJ cord-294854-rvrgcugn 94 10 as as IN cord-294854-rvrgcugn 94 11 immunomodulators immunomodulator NNS cord-294854-rvrgcugn 94 12 and and CC cord-294854-rvrgcugn 94 13 cytokine cytokine NN cord-294854-rvrgcugn 94 14 antagonists antagonist NNS cord-294854-rvrgcugn 94 15 is be VBZ cord-294854-rvrgcugn 94 16 essential essential JJ cord-294854-rvrgcugn 94 17 to to TO cord-294854-rvrgcugn 94 18 improve improve VB cord-294854-rvrgcugn 94 19 the the DT cord-294854-rvrgcugn 94 20 survival survival NN cord-294854-rvrgcugn 94 21 rate rate NN cord-294854-rvrgcugn 94 22 of of IN cord-294854-rvrgcugn 94 23 COVID-19 covid-19 JJ cord-294854-rvrgcugn 94 24 patients patient NNS cord-294854-rvrgcugn 94 25 . . . cord-294854-rvrgcugn 95 1 Although although IN cord-294854-rvrgcugn 95 2 many many JJ cord-294854-rvrgcugn 95 3 research research NN cord-294854-rvrgcugn 95 4 articles article NNS cord-294854-rvrgcugn 95 5 are be VBP cord-294854-rvrgcugn 95 6 published publish VBN cord-294854-rvrgcugn 95 7 each each DT cord-294854-rvrgcugn 95 8 month month NN cord-294854-rvrgcugn 95 9 , , , cord-294854-rvrgcugn 95 10 majority majority NN cord-294854-rvrgcugn 95 11 of of IN cord-294854-rvrgcugn 95 12 the the DT cord-294854-rvrgcugn 95 13 existing exist VBG cord-294854-rvrgcugn 95 14 literature literature NN cord-294854-rvrgcugn 95 15 about about IN cord-294854-rvrgcugn 95 16 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 95 17 comes come VBZ cord-294854-rvrgcugn 95 18 from from IN cord-294854-rvrgcugn 95 19 descriptive descriptive JJ cord-294854-rvrgcugn 95 20 works work NNS cord-294854-rvrgcugn 95 21 . . . cord-294854-rvrgcugn 96 1 Additionally additionally RB cord-294854-rvrgcugn 96 2 , , , cord-294854-rvrgcugn 96 3 high high JJ cord-294854-rvrgcugn 96 4 - - HYPH cord-294854-rvrgcugn 96 5 quality quality NN cord-294854-rvrgcugn 96 6 evidence evidence NN cord-294854-rvrgcugn 96 7 will will MD cord-294854-rvrgcugn 96 8 be be VB cord-294854-rvrgcugn 96 9 necessary necessary JJ cord-294854-rvrgcugn 96 10 to to TO cord-294854-rvrgcugn 96 11 understand understand VB cord-294854-rvrgcugn 96 12 and and CC cord-294854-rvrgcugn 96 13 treat treat VB cord-294854-rvrgcugn 96 14 the the DT cord-294854-rvrgcugn 96 15 cytokine cytokine NN cord-294854-rvrgcugn 96 16 storm storm NN cord-294854-rvrgcugn 96 17 of of IN cord-294854-rvrgcugn 96 18 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 96 19 . . . cord-294854-rvrgcugn 96 20 _SP cord-294854-rvrgcugn 97 1 Potential potential JJ cord-294854-rvrgcugn 97 2 for for IN cord-294854-rvrgcugn 97 3 global global JJ cord-294854-rvrgcugn 97 4 spread spread NN cord-294854-rvrgcugn 97 5 of of IN cord-294854-rvrgcugn 97 6 a a DT cord-294854-rvrgcugn 97 7 novel novel JJ cord-294854-rvrgcugn 97 8 coronavirus coronavirus NN cord-294854-rvrgcugn 97 9 from from IN cord-294854-rvrgcugn 97 10 China China NNP cord-294854-rvrgcugn 97 11 Clinical clinical JJ cord-294854-rvrgcugn 97 12 features feature NNS cord-294854-rvrgcugn 97 13 of of IN cord-294854-rvrgcugn 97 14 patients patient NNS cord-294854-rvrgcugn 97 15 infected infect VBN cord-294854-rvrgcugn 97 16 with with IN cord-294854-rvrgcugn 97 17 2019 2019 CD cord-294854-rvrgcugn 97 18 novel novel JJ cord-294854-rvrgcugn 97 19 coronavirus coronavirus NN cord-294854-rvrgcugn 97 20 in in IN cord-294854-rvrgcugn 97 21 Wuhan Wuhan NNP cord-294854-rvrgcugn 98 1 An an DT cord-294854-rvrgcugn 98 2 interferon interferon NN cord-294854-rvrgcugn 98 3 - - HYPH cord-294854-rvrgcugn 98 4 gamma gamma NN cord-294854-rvrgcugn 98 5 - - HYPH cord-294854-rvrgcugn 98 6 related relate VBN cord-294854-rvrgcugn 98 7 cytokine cytokine NN cord-294854-rvrgcugn 98 8 storm storm NN cord-294854-rvrgcugn 98 9 in in IN cord-294854-rvrgcugn 98 10 SARS SARS NNP cord-294854-rvrgcugn 98 11 patients patient NNS cord-294854-rvrgcugn 98 12 Active active JJ cord-294854-rvrgcugn 98 13 replication replication NN cord-294854-rvrgcugn 98 14 of of IN cord-294854-rvrgcugn 98 15 Middle Middle NNP cord-294854-rvrgcugn 98 16 East East NNP cord-294854-rvrgcugn 98 17 respiratory respiratory JJ cord-294854-rvrgcugn 98 18 syndrome syndrome NN cord-294854-rvrgcugn 98 19 coronavirus coronavirus NN cord-294854-rvrgcugn 98 20 and and CC cord-294854-rvrgcugn 98 21 aberrant aberrant JJ cord-294854-rvrgcugn 98 22 induction induction NN cord-294854-rvrgcugn 98 23 of of IN cord-294854-rvrgcugn 98 24 inflammatory inflammatory JJ cord-294854-rvrgcugn 98 25 cytokines cytokine NNS cord-294854-rvrgcugn 98 26 and and CC cord-294854-rvrgcugn 98 27 chemokines chemokine NNS cord-294854-rvrgcugn 98 28 in in IN cord-294854-rvrgcugn 98 29 human human JJ cord-294854-rvrgcugn 98 30 macrophages macrophage NNS cord-294854-rvrgcugn 98 31 : : : cord-294854-rvrgcugn 98 32 implications implication NNS cord-294854-rvrgcugn 98 33 for for IN cord-294854-rvrgcugn 98 34 pathogenesis pathogenesis NN cord-294854-rvrgcugn 98 35 COVID-19 covid-19 NN cord-294854-rvrgcugn 98 36 : : : cord-294854-rvrgcugn 98 37 consider consider VB cord-294854-rvrgcugn 98 38 cytokine cytokine JJ cord-294854-rvrgcugn 98 39 storm storm NN cord-294854-rvrgcugn 98 40 syndromes syndrome NNS cord-294854-rvrgcugn 98 41 and and CC cord-294854-rvrgcugn 98 42 immunosuppression immunosuppression NN cord-294854-rvrgcugn 98 43 Chapter chapter NN cord-294854-rvrgcugn 98 44 Eight eight CD cord-294854-rvrgcugn 99 1 -Hosts -host NNS cord-294854-rvrgcugn 100 1 and and CC cord-294854-rvrgcugn 100 2 Sources source NNS cord-294854-rvrgcugn 100 3 of of IN cord-294854-rvrgcugn 100 4 Endemic Endemic NNP cord-294854-rvrgcugn 100 5 Human Human NNP cord-294854-rvrgcugn 100 6 Coronaviruses Coronaviruses NNPS cord-294854-rvrgcugn 100 7 Coronaviridae Coronaviridae NNP cord-294854-rvrgcugn 100 8 Study Study NNP cord-294854-rvrgcugn 100 9 Group Group NNP cord-294854-rvrgcugn 100 10 of of IN cord-294854-rvrgcugn 100 11 the the DT cord-294854-rvrgcugn 100 12 International International NNP cord-294854-rvrgcugn 100 13 Committee Committee NNP cord-294854-rvrgcugn 100 14 on on IN cord-294854-rvrgcugn 100 15 Taxonomy Taxonomy NNP cord-294854-rvrgcugn 100 16 of of IN cord-294854-rvrgcugn 100 17 Viruses Viruses NNPS cord-294854-rvrgcugn 100 18 . . . cord-294854-rvrgcugn 101 1 The the DT cord-294854-rvrgcugn 101 2 species specie NNS cord-294854-rvrgcugn 101 3 Severe severe JJ cord-294854-rvrgcugn 101 4 acute acute JJ cord-294854-rvrgcugn 101 5 respiratory respiratory JJ cord-294854-rvrgcugn 101 6 syndrome syndrome NN cord-294854-rvrgcugn 101 7 - - HYPH cord-294854-rvrgcugn 101 8 related relate VBN cord-294854-rvrgcugn 101 9 coronavirus coronavirus NN cord-294854-rvrgcugn 101 10 : : : cord-294854-rvrgcugn 101 11 classifying classify VBG cord-294854-rvrgcugn 101 12 2019-nCoV 2019-ncov CD cord-294854-rvrgcugn 101 13 and and CC cord-294854-rvrgcugn 101 14 naming name VBG cord-294854-rvrgcugn 101 15 it -PRON- PRP cord-294854-rvrgcugn 101 16 SARS SARS NNP cord-294854-rvrgcugn 101 17 - - HYPH cord-294854-rvrgcugn 101 18 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 101 19 Genomic genomic JJ cord-294854-rvrgcugn 101 20 characterisation characterisation NN cord-294854-rvrgcugn 101 21 and and CC cord-294854-rvrgcugn 101 22 epidemiology epidemiology NN cord-294854-rvrgcugn 101 23 of of IN cord-294854-rvrgcugn 101 24 2019 2019 CD cord-294854-rvrgcugn 101 25 novel novel JJ cord-294854-rvrgcugn 101 26 coronavirus coronavirus NN cord-294854-rvrgcugn 101 27 : : : cord-294854-rvrgcugn 101 28 implications implication NNS cord-294854-rvrgcugn 101 29 for for IN cord-294854-rvrgcugn 101 30 virus virus NN cord-294854-rvrgcugn 101 31 origins origin NNS cord-294854-rvrgcugn 101 32 and and CC cord-294854-rvrgcugn 101 33 receptor receptor NN cord-294854-rvrgcugn 101 34 binding bind VBG cord-294854-rvrgcugn 101 35 A a DT cord-294854-rvrgcugn 101 36 pneumonia pneumonia NN cord-294854-rvrgcugn 101 37 outbreak outbreak NN cord-294854-rvrgcugn 101 38 associated associate VBN cord-294854-rvrgcugn 101 39 with with IN cord-294854-rvrgcugn 101 40 a a DT cord-294854-rvrgcugn 101 41 new new JJ cord-294854-rvrgcugn 101 42 coronavirus coronavirus NN cord-294854-rvrgcugn 101 43 of of IN cord-294854-rvrgcugn 101 44 probable probable JJ cord-294854-rvrgcugn 101 45 bat bat NN cord-294854-rvrgcugn 101 46 origin origin NN cord-294854-rvrgcugn 101 47 World World NNP cord-294854-rvrgcugn 101 48 Health Health NNP cord-294854-rvrgcugn 101 49 Organization Organization NNP cord-294854-rvrgcugn 101 50 W. W. NNP cord-294854-rvrgcugn 101 51 Coronavirus Coronavirus NNP cord-294854-rvrgcugn 101 52 disease disease NN cord-294854-rvrgcugn 101 53 ( ( -LRB- cord-294854-rvrgcugn 101 54 COVID-19)Situation COVID-19)Situation NNP cord-294854-rvrgcugn 101 55 Report Report NNP cord-294854-rvrgcugn 101 56 -112 -112 NNP cord-294854-rvrgcugn 101 57 Genetic Genetic NNP cord-294854-rvrgcugn 101 58 Recombination Recombination NNP cord-294854-rvrgcugn 101 59 , , , cord-294854-rvrgcugn 101 60 and and CC cord-294854-rvrgcugn 101 61 Pathogenesis Pathogenesis NNP cord-294854-rvrgcugn 101 62 of of IN cord-294854-rvrgcugn 101 63 Coronaviruses Coronaviruses NNP cord-294854-rvrgcugn 101 64 Report Report NNP cord-294854-rvrgcugn 101 65 of of IN cord-294854-rvrgcugn 101 66 the the DT cord-294854-rvrgcugn 101 67 WHO WHO NNP cord-294854-rvrgcugn 101 68 - - HYPH cord-294854-rvrgcugn 101 69 China China NNP cord-294854-rvrgcugn 101 70 joint joint JJ cord-294854-rvrgcugn 101 71 mission mission NN cord-294854-rvrgcugn 101 72 on on IN cord-294854-rvrgcugn 101 73 coronavirus coronavirus NN cord-294854-rvrgcugn 101 74 disease disease NN cord-294854-rvrgcugn 101 75 2019 2019 CD cord-294854-rvrgcugn 101 76 ( ( -LRB- cord-294854-rvrgcugn 102 1 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 102 2 ) ) -RRB- cord-294854-rvrgcugn 102 3 2020 2020 CD cord-294854-rvrgcugn 102 4 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 102 5 , , , cord-294854-rvrgcugn 102 6 SARS SARS NNP cord-294854-rvrgcugn 102 7 and and CC cord-294854-rvrgcugn 102 8 MERS MERS NNP cord-294854-rvrgcugn 102 9 : : : cord-294854-rvrgcugn 102 10 are be VBP cord-294854-rvrgcugn 102 11 they -PRON- PRP cord-294854-rvrgcugn 102 12 closely closely RB cord-294854-rvrgcugn 102 13 related relate VBN cord-294854-rvrgcugn 102 14 ? ? . cord-294854-rvrgcugn 103 1 Origin origin NN cord-294854-rvrgcugn 103 2 and and CC cord-294854-rvrgcugn 103 3 evolution evolution NN cord-294854-rvrgcugn 103 4 of of IN cord-294854-rvrgcugn 103 5 pathogenic pathogenic JJ cord-294854-rvrgcugn 103 6 coronaviruses coronaviruse NNS cord-294854-rvrgcugn 104 1 The the DT cord-294854-rvrgcugn 104 2 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 104 3 Pandemic Pandemic NNP cord-294854-rvrgcugn 104 4 : : : cord-294854-rvrgcugn 105 1 A a DT cord-294854-rvrgcugn 105 2 Comprehensive Comprehensive NNP cord-294854-rvrgcugn 105 3 Review Review NNP cord-294854-rvrgcugn 105 4 of of IN cord-294854-rvrgcugn 105 5 Coronaviruses Coronaviruses NNP cord-294854-rvrgcugn 105 6 -drug -drug NNP cord-294854-rvrgcugn 105 7 discovery discovery NN cord-294854-rvrgcugn 105 8 and and CC cord-294854-rvrgcugn 105 9 therapeutic therapeutic JJ cord-294854-rvrgcugn 105 10 options option NNS cord-294854-rvrgcugn 105 11 Pathogenic pathogenic JJ cord-294854-rvrgcugn 105 12 human human JJ cord-294854-rvrgcugn 105 13 coronavirus coronavirus NN cord-294854-rvrgcugn 105 14 infections infection NNS cord-294854-rvrgcugn 105 15 : : : cord-294854-rvrgcugn 105 16 causes cause NNS cord-294854-rvrgcugn 105 17 and and CC cord-294854-rvrgcugn 105 18 consequences consequence NNS cord-294854-rvrgcugn 105 19 of of IN cord-294854-rvrgcugn 105 20 cytokine cytokine NN cord-294854-rvrgcugn 105 21 storm storm NN cord-294854-rvrgcugn 105 22 and and CC cord-294854-rvrgcugn 105 23 immunopathology immunopathology VBG cord-294854-rvrgcugn 105 24 Clinical clinical JJ cord-294854-rvrgcugn 105 25 Characteristics Characteristics NNPS cord-294854-rvrgcugn 105 26 of of IN cord-294854-rvrgcugn 105 27 Coronavirus Coronavirus NNP cord-294854-rvrgcugn 105 28 Disease Disease NNP cord-294854-rvrgcugn 105 29 2019 2019 CD cord-294854-rvrgcugn 105 30 in in IN cord-294854-rvrgcugn 105 31 China China NNP cord-294854-rvrgcugn 105 32 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 105 33 with with IN cord-294854-rvrgcugn 105 34 Different different JJ cord-294854-rvrgcugn 105 35 Severity severity NN cord-294854-rvrgcugn 105 36 : : : cord-294854-rvrgcugn 105 37 A a DT cord-294854-rvrgcugn 105 38 Multi multi JJ cord-294854-rvrgcugn 105 39 - - JJ cord-294854-rvrgcugn 105 40 center center JJ cord-294854-rvrgcugn 105 41 Study Study NNP cord-294854-rvrgcugn 105 42 of of IN cord-294854-rvrgcugn 105 43 Clinical Clinical NNP cord-294854-rvrgcugn 105 44 Features Features NNPS cord-294854-rvrgcugn 105 45 Mapping map VBG cord-294854-rvrgcugn 105 46 the the DT cord-294854-rvrgcugn 105 47 innate innate JJ cord-294854-rvrgcugn 105 48 signaling signal VBG cord-294854-rvrgcugn 105 49 cascade cascade NN cord-294854-rvrgcugn 105 50 essential essential NN cord-294854-rvrgcugn 105 51 for for IN cord-294854-rvrgcugn 105 52 cytokine cytokine JJ cord-294854-rvrgcugn 105 53 storm storm NN cord-294854-rvrgcugn 105 54 during during IN cord-294854-rvrgcugn 105 55 influenza influenza NN cord-294854-rvrgcugn 105 56 virus virus NN cord-294854-rvrgcugn 105 57 infection infection NN cord-294854-rvrgcugn 105 58 Pathological pathological JJ cord-294854-rvrgcugn 105 59 inflammation inflammation NN cord-294854-rvrgcugn 105 60 in in IN cord-294854-rvrgcugn 105 61 patients patient NNS cord-294854-rvrgcugn 105 62 with with IN cord-294854-rvrgcugn 105 63 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 105 64 : : : cord-294854-rvrgcugn 105 65 a a DT cord-294854-rvrgcugn 105 66 key key JJ cord-294854-rvrgcugn 105 67 role role NN cord-294854-rvrgcugn 105 68 for for IN cord-294854-rvrgcugn 105 69 monocytes monocyte NNS cord-294854-rvrgcugn 105 70 and and CC cord-294854-rvrgcugn 105 71 macrophages macrophage NNS cord-294854-rvrgcugn 105 72 Analysis Analysis NNP cord-294854-rvrgcugn 105 73 of of IN cord-294854-rvrgcugn 105 74 the the DT cord-294854-rvrgcugn 105 75 mutation mutation NN cord-294854-rvrgcugn 105 76 dynamics dynamic NNS cord-294854-rvrgcugn 105 77 of of IN cord-294854-rvrgcugn 105 78 SARS SARS NNP cord-294854-rvrgcugn 105 79 - - HYPH cord-294854-rvrgcugn 105 80 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 105 81 reveals reveal VBZ cord-294854-rvrgcugn 105 82 the the DT cord-294854-rvrgcugn 105 83 spread spread NN cord-294854-rvrgcugn 105 84 history history NN cord-294854-rvrgcugn 105 85 and and CC cord-294854-rvrgcugn 105 86 emergence emergence NN cord-294854-rvrgcugn 105 87 of of IN cord-294854-rvrgcugn 105 88 RBD RBD NNP cord-294854-rvrgcugn 105 89 mutant mutant JJ cord-294854-rvrgcugn 105 90 with with IN cord-294854-rvrgcugn 105 91 lower low JJR cord-294854-rvrgcugn 105 92 ACE2 ACE2 NNP cord-294854-rvrgcugn 105 93 binding bind VBG cord-294854-rvrgcugn 105 94 affinity affinity NN cord-294854-rvrgcugn 105 95 Phylogenetic Phylogenetic NNP cord-294854-rvrgcugn 105 96 network network NN cord-294854-rvrgcugn 105 97 analysis analysis NN cord-294854-rvrgcugn 105 98 of of IN cord-294854-rvrgcugn 105 99 SARS SARS NNP cord-294854-rvrgcugn 105 100 - - HYPH cord-294854-rvrgcugn 105 101 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 105 102 genomes genome NNS cord-294854-rvrgcugn 105 103 Patient patient NN cord-294854-rvrgcugn 105 104 - - HYPH cord-294854-rvrgcugn 105 105 derived derive VBN cord-294854-rvrgcugn 105 106 mutations mutation NNS cord-294854-rvrgcugn 105 107 impact impact NN cord-294854-rvrgcugn 105 108 pathogenicity pathogenicity NN cord-294854-rvrgcugn 105 109 of of IN cord-294854-rvrgcugn 105 110 SARS SARS NNP cord-294854-rvrgcugn 105 111 - - HYPH cord-294854-rvrgcugn 105 112 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 105 113 Pathological pathological JJ cord-294854-rvrgcugn 105 114 findings finding NNS cord-294854-rvrgcugn 105 115 of of IN cord-294854-rvrgcugn 105 116 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 105 117 associated associate VBN cord-294854-rvrgcugn 105 118 with with IN cord-294854-rvrgcugn 105 119 acute acute JJ cord-294854-rvrgcugn 105 120 respiratory respiratory JJ cord-294854-rvrgcugn 105 121 distress distress NN cord-294854-rvrgcugn 105 122 syndrome syndrome NN cord-294854-rvrgcugn 106 1 Pathological pathological JJ cord-294854-rvrgcugn 106 2 evidence evidence NN cord-294854-rvrgcugn 106 3 for for IN cord-294854-rvrgcugn 106 4 residual residual JJ cord-294854-rvrgcugn 106 5 SARS SARS NNP cord-294854-rvrgcugn 106 6 - - HYPH cord-294854-rvrgcugn 106 7 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 106 8 in in IN cord-294854-rvrgcugn 106 9 pulmonary pulmonary JJ cord-294854-rvrgcugn 106 10 tissues tissue NNS cord-294854-rvrgcugn 106 11 of of IN cord-294854-rvrgcugn 106 12 a a DT cord-294854-rvrgcugn 106 13 ready ready JJ cord-294854-rvrgcugn 106 14 - - HYPH cord-294854-rvrgcugn 106 15 for for IN cord-294854-rvrgcugn 106 16 - - HYPH cord-294854-rvrgcugn 106 17 discharge discharge NN cord-294854-rvrgcugn 106 18 patient patient NN cord-294854-rvrgcugn 106 19 SARS SARS NNP cord-294854-rvrgcugn 106 20 - - HYPH cord-294854-rvrgcugn 106 21 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 106 22 and and CC cord-294854-rvrgcugn 106 23 viral viral JJ cord-294854-rvrgcugn 106 24 sepsis sepsis NN cord-294854-rvrgcugn 106 25 : : : cord-294854-rvrgcugn 107 1 observations observation NNS cord-294854-rvrgcugn 107 2 and and CC cord-294854-rvrgcugn 107 3 hypotheses hypothesis NNS cord-294854-rvrgcugn 108 1 Histopathologic Histopathologic NNP cord-294854-rvrgcugn 108 2 Changes Changes NNPS cord-294854-rvrgcugn 108 3 and and CC cord-294854-rvrgcugn 108 4 SARS SARS NNP cord-294854-rvrgcugn 108 5 - - HYPH cord-294854-rvrgcugn 108 6 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 109 1 Immunostaining immunostaine VBG cord-294854-rvrgcugn 109 2 in in IN cord-294854-rvrgcugn 109 3 the the DT cord-294854-rvrgcugn 109 4 Lung Lung NNP cord-294854-rvrgcugn 109 5 of of IN cord-294854-rvrgcugn 109 6 a a DT cord-294854-rvrgcugn 109 7 Patient patient NN cord-294854-rvrgcugn 109 8 With with IN cord-294854-rvrgcugn 110 1 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 110 2 Immune Immune NNP cord-294854-rvrgcugn 110 3 response response NN cord-294854-rvrgcugn 110 4 to to IN cord-294854-rvrgcugn 110 5 SARS SARS NNP cord-294854-rvrgcugn 110 6 - - HYPH cord-294854-rvrgcugn 110 7 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 110 8 and and CC cord-294854-rvrgcugn 110 9 mechanisms mechanism NNS cord-294854-rvrgcugn 110 10 of of IN cord-294854-rvrgcugn 110 11 immunopathological immunopathological JJ cord-294854-rvrgcugn 110 12 changes change NNS cord-294854-rvrgcugn 110 13 in in IN cord-294854-rvrgcugn 110 14 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 110 15 The the DT cord-294854-rvrgcugn 110 16 clinical clinical JJ cord-294854-rvrgcugn 110 17 pathology pathology NN cord-294854-rvrgcugn 110 18 of of IN cord-294854-rvrgcugn 110 19 severe severe JJ cord-294854-rvrgcugn 110 20 acute acute JJ cord-294854-rvrgcugn 110 21 respiratory respiratory JJ cord-294854-rvrgcugn 110 22 syndrome syndrome NN cord-294854-rvrgcugn 110 23 ( ( -LRB- cord-294854-rvrgcugn 110 24 SARS SARS NNP cord-294854-rvrgcugn 110 25 ) ) -RRB- cord-294854-rvrgcugn 110 26 : : : cord-294854-rvrgcugn 111 1 a a DT cord-294854-rvrgcugn 111 2 report report NN cord-294854-rvrgcugn 111 3 from from IN cord-294854-rvrgcugn 111 4 Immunohistochemical Immunohistochemical NNP cord-294854-rvrgcugn 111 5 , , , cord-294854-rvrgcugn 111 6 and and CC cord-294854-rvrgcugn 111 7 Ultrastructural Ultrastructural NNP cord-294854-rvrgcugn 111 8 Findings Findings NNPS cord-294854-rvrgcugn 111 9 of of IN cord-294854-rvrgcugn 111 10 a a DT cord-294854-rvrgcugn 111 11 Fatal Fatal NNP cord-294854-rvrgcugn 111 12 Case Case NNP cord-294854-rvrgcugn 111 13 of of IN cord-294854-rvrgcugn 111 14 Middle Middle NNP cord-294854-rvrgcugn 111 15 East East NNP cord-294854-rvrgcugn 111 16 Respiratory Respiratory NNP cord-294854-rvrgcugn 111 17 Syndrome Syndrome NNP cord-294854-rvrgcugn 111 18 Coronavirus Coronavirus NNP cord-294854-rvrgcugn 111 19 Infection infection NN cord-294854-rvrgcugn 111 20 in in IN cord-294854-rvrgcugn 111 21 the the DT cord-294854-rvrgcugn 111 22 United United NNP cord-294854-rvrgcugn 111 23 Arab Arab NNP cord-294854-rvrgcugn 111 24 Emirates Emirates NNPS cord-294854-rvrgcugn 111 25 Lower lower RBR cord-294854-rvrgcugn 111 26 tidal tidal JJ cord-294854-rvrgcugn 111 27 volume volume NN cord-294854-rvrgcugn 111 28 ventilation ventilation NN cord-294854-rvrgcugn 111 29 and and CC cord-294854-rvrgcugn 111 30 plasma plasma NN cord-294854-rvrgcugn 111 31 cytokine cytokine NN cord-294854-rvrgcugn 111 32 markers marker NNS cord-294854-rvrgcugn 111 33 of of IN cord-294854-rvrgcugn 111 34 inflammation inflammation NN cord-294854-rvrgcugn 111 35 in in IN cord-294854-rvrgcugn 111 36 patients patient NNS cord-294854-rvrgcugn 111 37 with with IN cord-294854-rvrgcugn 111 38 acute acute JJ cord-294854-rvrgcugn 111 39 lung lung NN cord-294854-rvrgcugn 111 40 injury injury NN cord-294854-rvrgcugn 111 41 SARS SARS NNP cord-294854-rvrgcugn 111 42 - - HYPH cord-294854-rvrgcugn 111 43 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 111 44 Cell Cell NNP cord-294854-rvrgcugn 111 45 Entry entry NN cord-294854-rvrgcugn 111 46 Depends depend VBZ cord-294854-rvrgcugn 111 47 on on IN cord-294854-rvrgcugn 111 48 ACE2 ACE2 NNP cord-294854-rvrgcugn 111 49 and and CC cord-294854-rvrgcugn 111 50 TMPRSS2 TMPRSS2 NNP cord-294854-rvrgcugn 111 51 and and CC cord-294854-rvrgcugn 111 52 Is be VBZ cord-294854-rvrgcugn 111 53 Blocked block VBN cord-294854-rvrgcugn 111 54 by by IN cord-294854-rvrgcugn 111 55 a a DT cord-294854-rvrgcugn 111 56 Clinically clinically RB cord-294854-rvrgcugn 111 57 Proven prove VBN cord-294854-rvrgcugn 111 58 Protease Protease NNP cord-294854-rvrgcugn 111 59 Inhibitor Inhibitor NNP cord-294854-rvrgcugn 111 60 Cellular Cellular NNP cord-294854-rvrgcugn 111 61 and and CC cord-294854-rvrgcugn 111 62 molecular molecular JJ cord-294854-rvrgcugn 111 63 pathways pathway NNS cord-294854-rvrgcugn 111 64 of of IN cord-294854-rvrgcugn 111 65 COVID-19 covid-19 JJ cord-294854-rvrgcugn 111 66 and and CC cord-294854-rvrgcugn 111 67 potential potential JJ cord-294854-rvrgcugn 111 68 points point NNS cord-294854-rvrgcugn 111 69 of of IN cord-294854-rvrgcugn 111 70 therapeutic therapeutic JJ cord-294854-rvrgcugn 111 71 intervention intervention NN cord-294854-rvrgcugn 111 72 Aberrant aberrant JJ cord-294854-rvrgcugn 111 73 pathogenic pathogenic JJ cord-294854-rvrgcugn 111 74 GM GM NNP cord-294854-rvrgcugn 111 75 - - HYPH cord-294854-rvrgcugn 111 76 CSF+ CSF+ NNP cord-294854-rvrgcugn 111 77 T T NNP cord-294854-rvrgcugn 111 78 cells cell NNS cord-294854-rvrgcugn 111 79 and and CC cord-294854-rvrgcugn 111 80 inflammatory inflammatory JJ cord-294854-rvrgcugn 111 81 CD14+CD16 CD14+CD16 NNP cord-294854-rvrgcugn 111 82 + + CC cord-294854-rvrgcugn 111 83 monocytes monocyte NNS cord-294854-rvrgcugn 111 84 in in IN cord-294854-rvrgcugn 111 85 severe severe JJ cord-294854-rvrgcugn 111 86 pulmonary pulmonary JJ cord-294854-rvrgcugn 111 87 syndrome syndrome NN cord-294854-rvrgcugn 111 88 patients patient NNS cord-294854-rvrgcugn 111 89 of of IN cord-294854-rvrgcugn 111 90 a a DT cord-294854-rvrgcugn 111 91 new new JJ cord-294854-rvrgcugn 111 92 coronavirus coronavirus NN cord-294854-rvrgcugn 111 93 Neutrophil Neutrophil NNP cord-294854-rvrgcugn 111 94 extracellular extracellular JJ cord-294854-rvrgcugn 111 95 traps trap NNS cord-294854-rvrgcugn 111 96 in in IN cord-294854-rvrgcugn 111 97 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 111 98 . . . cord-294854-rvrgcugn 112 1 JCI JCI NNP cord-294854-rvrgcugn 112 2 insight insight NN cord-294854-rvrgcugn 113 1 COVID-19 covid-19 VB cord-294854-rvrgcugn 113 2 : : : cord-294854-rvrgcugn 113 3 A a DT cord-294854-rvrgcugn 113 4 New New NNP cord-294854-rvrgcugn 113 5 Virus virus NN cord-294854-rvrgcugn 113 6 , , , cord-294854-rvrgcugn 113 7 but but CC cord-294854-rvrgcugn 113 8 a a DT cord-294854-rvrgcugn 113 9 Familiar familiar JJ cord-294854-rvrgcugn 113 10 Receptor receptor NN cord-294854-rvrgcugn 113 11 and and CC cord-294854-rvrgcugn 113 12 Cytokine Cytokine NNP cord-294854-rvrgcugn 113 13 Release Release NNP cord-294854-rvrgcugn 113 14 Syndrome syndrome NN cord-294854-rvrgcugn 114 1 Understanding understand VBG cord-294854-rvrgcugn 114 2 Angiotensin Angiotensin NNP cord-294854-rvrgcugn 114 3 II II NNP cord-294854-rvrgcugn 114 4 Type Type NNP cord-294854-rvrgcugn 114 5 1 1 CD cord-294854-rvrgcugn 114 6 Receptor receptor NN cord-294854-rvrgcugn 114 7 Signaling Signaling NNP cord-294854-rvrgcugn 114 8 in in IN cord-294854-rvrgcugn 114 9 Vascular Vascular NNP cord-294854-rvrgcugn 114 10 Pathophysiology Pathophysiology NNP cord-294854-rvrgcugn 114 11 . . . cord-294854-rvrgcugn 115 1 Hypertension hypertension NN cord-294854-rvrgcugn 115 2 ( ( -LRB- cord-294854-rvrgcugn 115 3 Dallas Dallas NNP cord-294854-rvrgcugn 115 4 , , , cord-294854-rvrgcugn 115 5 Tex Tex NNP cord-294854-rvrgcugn 115 6 : : : cord-294854-rvrgcugn 115 7 1979 1979 CD cord-294854-rvrgcugn 115 8 ) ) -RRB- cord-294854-rvrgcugn 116 1 Pleiotropy Pleiotropy NNP cord-294854-rvrgcugn 116 2 and and CC cord-294854-rvrgcugn 116 3 Specificity Specificity NNP cord-294854-rvrgcugn 116 4 : : : cord-294854-rvrgcugn 117 1 Insights insight NNS cord-294854-rvrgcugn 117 2 from from IN cord-294854-rvrgcugn 117 3 the the DT cord-294854-rvrgcugn 117 4 Interleukin Interleukin NNP cord-294854-rvrgcugn 117 5 6 6 CD cord-294854-rvrgcugn 117 6 Family Family NNP cord-294854-rvrgcugn 117 7 of of IN cord-294854-rvrgcugn 117 8 Cytokines Cytokines NNP cord-294854-rvrgcugn 117 9 Cytokine Cytokine NNP cord-294854-rvrgcugn 117 10 release release NN cord-294854-rvrgcugn 117 11 syndrome syndrome NN cord-294854-rvrgcugn 117 12 in in IN cord-294854-rvrgcugn 117 13 severe severe JJ cord-294854-rvrgcugn 117 14 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 117 15 Plasma Plasma NNP cord-294854-rvrgcugn 117 16 inflammatory inflammatory JJ cord-294854-rvrgcugn 117 17 cytokines cytokine NNS cord-294854-rvrgcugn 117 18 and and CC cord-294854-rvrgcugn 117 19 chemokines chemokine NNS cord-294854-rvrgcugn 117 20 in in IN cord-294854-rvrgcugn 117 21 severe severe JJ cord-294854-rvrgcugn 117 22 acute acute JJ cord-294854-rvrgcugn 117 23 respiratory respiratory JJ cord-294854-rvrgcugn 117 24 syndrome syndrome NN cord-294854-rvrgcugn 117 25 MERS MERS NNP cord-294854-rvrgcugn 117 26 - - HYPH cord-294854-rvrgcugn 117 27 CoV cov NN cord-294854-rvrgcugn 117 28 infection infection NN cord-294854-rvrgcugn 117 29 in in IN cord-294854-rvrgcugn 117 30 humans human NNS cord-294854-rvrgcugn 117 31 is be VBZ cord-294854-rvrgcugn 117 32 associated associate VBN cord-294854-rvrgcugn 117 33 with with IN cord-294854-rvrgcugn 117 34 a a DT cord-294854-rvrgcugn 117 35 pro pro JJ cord-294854-rvrgcugn 117 36 - - JJ cord-294854-rvrgcugn 117 37 inflammatory inflammatory JJ cord-294854-rvrgcugn 117 38 Th1 th1 NN cord-294854-rvrgcugn 117 39 and and CC cord-294854-rvrgcugn 117 40 Th17 Th17 NNP cord-294854-rvrgcugn 117 41 cytokine cytokine NN cord-294854-rvrgcugn 117 42 profile profile NN cord-294854-rvrgcugn 117 43 Clinical clinical JJ cord-294854-rvrgcugn 117 44 and and CC cord-294854-rvrgcugn 117 45 immunological immunological JJ cord-294854-rvrgcugn 117 46 features feature NNS cord-294854-rvrgcugn 117 47 of of IN cord-294854-rvrgcugn 117 48 severe severe JJ cord-294854-rvrgcugn 117 49 and and CC cord-294854-rvrgcugn 117 50 moderate moderate JJ cord-294854-rvrgcugn 117 51 coronavirus coronavirus NN cord-294854-rvrgcugn 117 52 disease disease NN cord-294854-rvrgcugn 117 53 2019 2019 CD cord-294854-rvrgcugn 117 54 Longitudinal longitudinal JJ cord-294854-rvrgcugn 117 55 characteristics characteristic NNS cord-294854-rvrgcugn 117 56 of of IN cord-294854-rvrgcugn 117 57 lymphocyte lymphocyte NN cord-294854-rvrgcugn 117 58 responses response NNS cord-294854-rvrgcugn 117 59 and and CC cord-294854-rvrgcugn 117 60 cytokine cytokine NN cord-294854-rvrgcugn 117 61 profiles profile NNS cord-294854-rvrgcugn 117 62 in in IN cord-294854-rvrgcugn 117 63 the the DT cord-294854-rvrgcugn 117 64 peripheral peripheral JJ cord-294854-rvrgcugn 117 65 blood blood NN cord-294854-rvrgcugn 117 66 of of IN cord-294854-rvrgcugn 117 67 SARS SARS NNP cord-294854-rvrgcugn 117 68 - - HYPH cord-294854-rvrgcugn 117 69 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 117 70 infected infect VBN cord-294854-rvrgcugn 117 71 patients patient NNS cord-294854-rvrgcugn 118 1 A a DT cord-294854-rvrgcugn 118 2 Dynamic dynamic JJ cord-294854-rvrgcugn 118 3 Immune Immune NNP cord-294854-rvrgcugn 118 4 Response response NN cord-294854-rvrgcugn 118 5 Shapes Shapes NNPS cord-294854-rvrgcugn 118 6 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 118 7 Cell Cell NNP cord-294854-rvrgcugn 118 8 host host NN cord-294854-rvrgcugn 118 9 & & CC cord-294854-rvrgcugn 118 10 microbe microbe NN cord-294854-rvrgcugn 118 11 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 118 12 infection infection NN cord-294854-rvrgcugn 118 13 and and CC cord-294854-rvrgcugn 118 14 rheumatoid rheumatoid NN cord-294854-rvrgcugn 118 15 arthritis arthritis NN cord-294854-rvrgcugn 118 16 : : : cord-294854-rvrgcugn 119 1 Faraway faraway RB cord-294854-rvrgcugn 119 2 , , , cord-294854-rvrgcugn 119 3 so so RB cord-294854-rvrgcugn 119 4 close close RB cord-294854-rvrgcugn 119 5 ! ! . cord-294854-rvrgcugn 120 1 Autoimmun Autoimmun NNP cord-294854-rvrgcugn 120 2 Rev Rev NNP cord-294854-rvrgcugn 120 3 Treatment Treatment NNP cord-294854-rvrgcugn 120 4 of of IN cord-294854-rvrgcugn 120 5 severe severe JJ cord-294854-rvrgcugn 120 6 acute acute JJ cord-294854-rvrgcugn 120 7 respiratory respiratory JJ cord-294854-rvrgcugn 120 8 syndrome syndrome NN cord-294854-rvrgcugn 120 9 with with IN cord-294854-rvrgcugn 120 10 glucosteroids glucosteroid NNS cord-294854-rvrgcugn 120 11 : : : cord-294854-rvrgcugn 121 1 the the DT cord-294854-rvrgcugn 121 2 Guangzhou Guangzhou NNP cord-294854-rvrgcugn 121 3 experience experience NN cord-294854-rvrgcugn 121 4 On on IN cord-294854-rvrgcugn 121 5 the the DT cord-294854-rvrgcugn 121 6 use use NN cord-294854-rvrgcugn 121 7 of of IN cord-294854-rvrgcugn 121 8 corticosteroids corticosteroid NNS cord-294854-rvrgcugn 121 9 for for IN cord-294854-rvrgcugn 121 10 2019-nCoV 2019-ncov CD cord-294854-rvrgcugn 121 11 pneumonia pneumonia NN cord-294854-rvrgcugn 121 12 Clinical clinical JJ cord-294854-rvrgcugn 121 13 evidence evidence NN cord-294854-rvrgcugn 121 14 does do VBZ cord-294854-rvrgcugn 121 15 not not RB cord-294854-rvrgcugn 121 16 support support VB cord-294854-rvrgcugn 121 17 corticosteroid corticosteroid NN cord-294854-rvrgcugn 121 18 treatment treatment NN cord-294854-rvrgcugn 121 19 for for IN cord-294854-rvrgcugn 121 20 2019-nCoV 2019-ncov CD cord-294854-rvrgcugn 121 21 lung lung NN cord-294854-rvrgcugn 121 22 injury injury NN cord-294854-rvrgcugn 122 1 The the DT cord-294854-rvrgcugn 122 2 effect effect NN cord-294854-rvrgcugn 122 3 of of IN cord-294854-rvrgcugn 122 4 corticosteroid corticosteroid NN cord-294854-rvrgcugn 122 5 treatment treatment NN cord-294854-rvrgcugn 122 6 on on IN cord-294854-rvrgcugn 122 7 patients patient NNS cord-294854-rvrgcugn 122 8 with with IN cord-294854-rvrgcugn 122 9 coronavirus coronavirus NN cord-294854-rvrgcugn 122 10 infection infection NN cord-294854-rvrgcugn 122 11 : : : cord-294854-rvrgcugn 122 12 a a DT cord-294854-rvrgcugn 122 13 systematic systematic JJ cord-294854-rvrgcugn 122 14 review review NN cord-294854-rvrgcugn 122 15 and and CC cord-294854-rvrgcugn 122 16 meta meta NNP cord-294854-rvrgcugn 122 17 - - HYPH cord-294854-rvrgcugn 122 18 analysis analysis NN cord-294854-rvrgcugn 122 19 . . . cord-294854-rvrgcugn 123 1 The the DT cord-294854-rvrgcugn 123 2 Journal Journal NNP cord-294854-rvrgcugn 123 3 of of IN cord-294854-rvrgcugn 123 4 infection infection NN cord-294854-rvrgcugn 123 5 Hydroxychloroquine Hydroxychloroquine NNP cord-294854-rvrgcugn 123 6 inhibits inhibit VBZ cord-294854-rvrgcugn 123 7 CD154 cd154 CD cord-294854-rvrgcugn 123 8 expression expression NN cord-294854-rvrgcugn 123 9 in in IN cord-294854-rvrgcugn 123 10 CD4 CD4 NNP cord-294854-rvrgcugn 123 11 T T NNP cord-294854-rvrgcugn 123 12 lymphocytes lymphocyte NNS cord-294854-rvrgcugn 123 13 of of IN cord-294854-rvrgcugn 123 14 systemic systemic JJ cord-294854-rvrgcugn 123 15 lupus lupus NN cord-294854-rvrgcugn 123 16 erythematosus erythematosus NN cord-294854-rvrgcugn 123 17 through through IN cord-294854-rvrgcugn 123 18 NFAT NFAT NNP cord-294854-rvrgcugn 123 19 , , , cord-294854-rvrgcugn 123 20 but but CC cord-294854-rvrgcugn 123 21 not not RB cord-294854-rvrgcugn 123 22 STAT5 stat5 RB cord-294854-rvrgcugn 123 23 , , , cord-294854-rvrgcugn 123 24 signaling signal VBG cord-294854-rvrgcugn 123 25 Effects effect NNS cord-294854-rvrgcugn 123 26 of of IN cord-294854-rvrgcugn 123 27 chloroquine chloroquine NN cord-294854-rvrgcugn 123 28 on on IN cord-294854-rvrgcugn 123 29 viral viral JJ cord-294854-rvrgcugn 123 30 infections infection NNS cord-294854-rvrgcugn 123 31 : : : cord-294854-rvrgcugn 123 32 an an DT cord-294854-rvrgcugn 123 33 old old JJ cord-294854-rvrgcugn 123 34 drug drug NN cord-294854-rvrgcugn 123 35 against against IN cord-294854-rvrgcugn 123 36 today today NN cord-294854-rvrgcugn 123 37 's 's POS cord-294854-rvrgcugn 123 38 diseases disease NNS cord-294854-rvrgcugn 123 39 ? ? . cord-294854-rvrgcugn 124 1 In in IN cord-294854-rvrgcugn 124 2 Vitro Vitro NNP cord-294854-rvrgcugn 124 3 Antiviral Antiviral NNP cord-294854-rvrgcugn 124 4 Activity Activity NNP cord-294854-rvrgcugn 124 5 and and CC cord-294854-rvrgcugn 124 6 Projection Projection NNP cord-294854-rvrgcugn 124 7 of of IN cord-294854-rvrgcugn 124 8 Optimized Optimized NNP cord-294854-rvrgcugn 124 9 Dosing Dosing NNP cord-294854-rvrgcugn 124 10 Design Design NNP cord-294854-rvrgcugn 124 11 of of IN cord-294854-rvrgcugn 124 12 Hydroxychloroquine Hydroxychloroquine NNP cord-294854-rvrgcugn 124 13 for for IN cord-294854-rvrgcugn 124 14 the the DT cord-294854-rvrgcugn 124 15 Treatment Treatment NNP cord-294854-rvrgcugn 124 16 of of IN cord-294854-rvrgcugn 124 17 Severe severe JJ cord-294854-rvrgcugn 124 18 Acute acute JJ cord-294854-rvrgcugn 124 19 Respiratory Respiratory NNP cord-294854-rvrgcugn 124 20 Syndrome Syndrome NNP cord-294854-rvrgcugn 124 21 Coronavirus Coronavirus NNP cord-294854-rvrgcugn 124 22 2 2 CD cord-294854-rvrgcugn 125 1 ( ( -LRB- cord-294854-rvrgcugn 125 2 SARS SARS NNP cord-294854-rvrgcugn 125 3 - - HYPH cord-294854-rvrgcugn 125 4 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 125 5 ) ) -RRB- cord-294854-rvrgcugn 125 6 Hydroxychloroquine Hydroxychloroquine NNP cord-294854-rvrgcugn 125 7 and and CC cord-294854-rvrgcugn 125 8 azithromycin azithromycin NNP cord-294854-rvrgcugn 125 9 as as IN cord-294854-rvrgcugn 125 10 a a DT cord-294854-rvrgcugn 125 11 treatment treatment NN cord-294854-rvrgcugn 125 12 of of IN cord-294854-rvrgcugn 125 13 COVID-19 covid-19 NN cord-294854-rvrgcugn 125 14 : : : cord-294854-rvrgcugn 125 15 results result NNS cord-294854-rvrgcugn 125 16 of of IN cord-294854-rvrgcugn 125 17 an an DT cord-294854-rvrgcugn 125 18 open open JJ cord-294854-rvrgcugn 125 19 - - HYPH cord-294854-rvrgcugn 125 20 label label NN cord-294854-rvrgcugn 125 21 non non JJ cord-294854-rvrgcugn 125 22 - - JJ cord-294854-rvrgcugn 125 23 randomized randomized JJ cord-294854-rvrgcugn 125 24 clinical clinical JJ cord-294854-rvrgcugn 125 25 trial trial NN cord-294854-rvrgcugn 125 26 Hydroxychloroquine Hydroxychloroquine NNP cord-294854-rvrgcugn 126 1 Versus versus IN cord-294854-rvrgcugn 127 1 COVID-19 covid-19 VB cord-294854-rvrgcugn 127 2 : : : cord-294854-rvrgcugn 127 3 A a DT cord-294854-rvrgcugn 127 4 Rapid Rapid NNP cord-294854-rvrgcugn 127 5 Systematic Systematic NNP cord-294854-rvrgcugn 127 6 Review Review NNP cord-294854-rvrgcugn 127 7 and and CC cord-294854-rvrgcugn 127 8 Meta Meta NNP cord-294854-rvrgcugn 127 9 - - HYPH cord-294854-rvrgcugn 127 10 Analysis Analysis NNP cord-294854-rvrgcugn 127 11 Chloroquine Chloroquine NNP cord-294854-rvrgcugn 127 12 analogues analogue NNS cord-294854-rvrgcugn 127 13 in in IN cord-294854-rvrgcugn 127 14 drug drug NN cord-294854-rvrgcugn 127 15 discovery discovery NN cord-294854-rvrgcugn 127 16 : : : cord-294854-rvrgcugn 128 1 new new JJ cord-294854-rvrgcugn 128 2 directions direction NNS cord-294854-rvrgcugn 128 3 of of IN cord-294854-rvrgcugn 128 4 uses use NNS cord-294854-rvrgcugn 128 5 , , , cord-294854-rvrgcugn 128 6 mechanisms mechanism NNS cord-294854-rvrgcugn 128 7 of of IN cord-294854-rvrgcugn 128 8 actions action NNS cord-294854-rvrgcugn 128 9 and and CC cord-294854-rvrgcugn 128 10 toxic toxic JJ cord-294854-rvrgcugn 128 11 manifestations manifestation NNS cord-294854-rvrgcugn 128 12 from from IN cord-294854-rvrgcugn 128 13 malaria malaria NN cord-294854-rvrgcugn 128 14 to to IN cord-294854-rvrgcugn 128 15 multifarious multifarious JJ cord-294854-rvrgcugn 128 16 diseases disease NNS cord-294854-rvrgcugn 128 17 Chloroquine Chloroquine NNP cord-294854-rvrgcugn 128 18 diphosphate diphosphate JJ cord-294854-rvrgcugn 128 19 in in IN cord-294854-rvrgcugn 128 20 two two CD cord-294854-rvrgcugn 128 21 different different JJ cord-294854-rvrgcugn 128 22 dosages dosage NNS cord-294854-rvrgcugn 128 23 as as IN cord-294854-rvrgcugn 128 24 adjunctive adjunctive JJ cord-294854-rvrgcugn 128 25 therapy therapy NN cord-294854-rvrgcugn 128 26 of of IN cord-294854-rvrgcugn 128 27 hospitalized hospitalize VBN cord-294854-rvrgcugn 128 28 patients patient NNS cord-294854-rvrgcugn 128 29 with with IN cord-294854-rvrgcugn 128 30 severe severe JJ cord-294854-rvrgcugn 128 31 respiratory respiratory JJ cord-294854-rvrgcugn 128 32 syndrome syndrome NN cord-294854-rvrgcugn 128 33 in in IN cord-294854-rvrgcugn 128 34 the the DT cord-294854-rvrgcugn 128 35 context context NN cord-294854-rvrgcugn 128 36 of of IN cord-294854-rvrgcugn 128 37 Accepted Accepted NNP cord-294854-rvrgcugn 128 38 Article Article NNP cord-294854-rvrgcugn 128 39 coronavirus coronavirus NN cord-294854-rvrgcugn 128 40 ( ( -LRB- cord-294854-rvrgcugn 128 41 SARS SARS NNP cord-294854-rvrgcugn 128 42 - - HYPH cord-294854-rvrgcugn 128 43 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 128 44 ) ) -RRB- cord-294854-rvrgcugn 128 45 infection infection NN cord-294854-rvrgcugn 128 46 : : : cord-294854-rvrgcugn 128 47 Preliminary preliminary JJ cord-294854-rvrgcugn 128 48 safety safety NN cord-294854-rvrgcugn 128 49 results result NNS cord-294854-rvrgcugn 128 50 of of IN cord-294854-rvrgcugn 128 51 a a DT cord-294854-rvrgcugn 128 52 randomized randomized JJ cord-294854-rvrgcugn 128 53 , , , cord-294854-rvrgcugn 128 54 double double JJ cord-294854-rvrgcugn 128 55 - - HYPH cord-294854-rvrgcugn 128 56 blinded blinded JJ cord-294854-rvrgcugn 128 57 , , , cord-294854-rvrgcugn 128 58 phase phase NN cord-294854-rvrgcugn 128 59 IIb iib JJ cord-294854-rvrgcugn 128 60 clinical clinical JJ cord-294854-rvrgcugn 128 61 trial trial NN cord-294854-rvrgcugn 128 62 ( ( -LRB- cord-294854-rvrgcugn 128 63 CloroCovid-19 CloroCovid-19 NNP cord-294854-rvrgcugn 128 64 Study Study NNP cord-294854-rvrgcugn 128 65 ) ) -RRB- cord-294854-rvrgcugn 128 66 Safety Safety NNP cord-294854-rvrgcugn 128 67 of of IN cord-294854-rvrgcugn 128 68 hydroxychloroquine hydroxychloroquine NN cord-294854-rvrgcugn 128 69 , , , cord-294854-rvrgcugn 128 70 alone alone JJ cord-294854-rvrgcugn 128 71 and and CC cord-294854-rvrgcugn 128 72 in in IN cord-294854-rvrgcugn 128 73 combination combination NN cord-294854-rvrgcugn 128 74 with with IN cord-294854-rvrgcugn 128 75 azithromycin azithromycin NNP cord-294854-rvrgcugn 128 76 , , , cord-294854-rvrgcugn 128 77 in in IN cord-294854-rvrgcugn 128 78 light light NN cord-294854-rvrgcugn 128 79 of of IN cord-294854-rvrgcugn 128 80 rapid rapid JJ cord-294854-rvrgcugn 128 81 wide wide JJ cord-294854-rvrgcugn 128 82 - - HYPH cord-294854-rvrgcugn 128 83 spread spread VBN cord-294854-rvrgcugn 128 84 use use NN cord-294854-rvrgcugn 128 85 for for IN cord-294854-rvrgcugn 128 86 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 128 87 : : : cord-294854-rvrgcugn 128 88 a a DT cord-294854-rvrgcugn 128 89 multinational multinational JJ cord-294854-rvrgcugn 128 90 , , , cord-294854-rvrgcugn 128 91 network network NN cord-294854-rvrgcugn 128 92 cohort cohort NN cord-294854-rvrgcugn 128 93 and and CC cord-294854-rvrgcugn 128 94 self self NN cord-294854-rvrgcugn 128 95 - - HYPH cord-294854-rvrgcugn 128 96 controlled control VBN cord-294854-rvrgcugn 128 97 case case NN cord-294854-rvrgcugn 128 98 series series NN cord-294854-rvrgcugn 128 99 study study NN cord-294854-rvrgcugn 128 100 The the DT cord-294854-rvrgcugn 128 101 cytokine cytokine NN cord-294854-rvrgcugn 128 102 release release NN cord-294854-rvrgcugn 128 103 syndrome syndrome NN cord-294854-rvrgcugn 128 104 ( ( -LRB- cord-294854-rvrgcugn 128 105 CRS CRS NNP cord-294854-rvrgcugn 128 106 ) ) -RRB- cord-294854-rvrgcugn 128 107 of of IN cord-294854-rvrgcugn 128 108 severe severe JJ cord-294854-rvrgcugn 128 109 COVID-19 covid-19 NN cord-294854-rvrgcugn 128 110 and and CC cord-294854-rvrgcugn 128 111 Interleukin-6 Interleukin-6 NNP cord-294854-rvrgcugn 129 1 receptor receptor NN cord-294854-rvrgcugn 129 2 ( ( -LRB- cord-294854-rvrgcugn 129 3 IL-6R IL-6R NNP cord-294854-rvrgcugn 129 4 ) ) -RRB- cord-294854-rvrgcugn 129 5 antagonist antagonist NN cord-294854-rvrgcugn 130 1 Tocilizumab Tocilizumab NNP cord-294854-rvrgcugn 130 2 may may MD cord-294854-rvrgcugn 130 3 be be VB cord-294854-rvrgcugn 130 4 the the DT cord-294854-rvrgcugn 130 5 key key NN cord-294854-rvrgcugn 130 6 to to TO cord-294854-rvrgcugn 130 7 reduce reduce VB cord-294854-rvrgcugn 130 8 the the DT cord-294854-rvrgcugn 130 9 mortality mortality NN cord-294854-rvrgcugn 130 10 Chinese Chinese NNP cord-294854-rvrgcugn 130 11 Clinical Clinical NNP cord-294854-rvrgcugn 130 12 Trail Trail NNP cord-294854-rvrgcugn 130 13 Registry Registry NNP cord-294854-rvrgcugn 130 14 . . . cord-294854-rvrgcugn 131 1 A a DT cord-294854-rvrgcugn 131 2 multicenter multicenter NN cord-294854-rvrgcugn 131 3 , , , cord-294854-rvrgcugn 131 4 randomized randomized JJ cord-294854-rvrgcugn 131 5 controlled control VBN cord-294854-rvrgcugn 131 6 trial trial NN cord-294854-rvrgcugn 131 7 for for IN cord-294854-rvrgcugn 131 8 the the DT cord-294854-rvrgcugn 131 9 efficacy efficacy NN cord-294854-rvrgcugn 131 10 and and CC cord-294854-rvrgcugn 131 11 safety safety NN cord-294854-rvrgcugn 131 12 of of IN cord-294854-rvrgcugn 131 13 tocilizumab tocilizumab NNP cord-294854-rvrgcugn 131 14 in in IN cord-294854-rvrgcugn 131 15 the the DT cord-294854-rvrgcugn 131 16 treatment treatment NN cord-294854-rvrgcugn 131 17 of of IN cord-294854-rvrgcugn 131 18 new new JJ cord-294854-rvrgcugn 131 19 coronavirus coronavirus NN cord-294854-rvrgcugn 131 20 pneumonia pneumonia NN cord-294854-rvrgcugn 131 21 Effective effective JJ cord-294854-rvrgcugn 131 22 treatment treatment NN cord-294854-rvrgcugn 131 23 of of IN cord-294854-rvrgcugn 131 24 severe severe JJ cord-294854-rvrgcugn 131 25 COVID-19 covid-19 JJ cord-294854-rvrgcugn 131 26 patients patient NNS cord-294854-rvrgcugn 131 27 with with IN cord-294854-rvrgcugn 131 28 tocilizumab tocilizumab NNP cord-294854-rvrgcugn 131 29 Improved Improved NNP cord-294854-rvrgcugn 131 30 survival survival NN cord-294854-rvrgcugn 131 31 outcome outcome NN cord-294854-rvrgcugn 131 32 in in IN cord-294854-rvrgcugn 131 33 SARs SARs NNP cord-294854-rvrgcugn 131 34 - - HYPH cord-294854-rvrgcugn 131 35 CoV-2 CoV-2 NNP cord-294854-rvrgcugn 131 36 ( ( -LRB- cord-294854-rvrgcugn 131 37 COVID-19 covid-19 VB cord-294854-rvrgcugn 131 38 ) ) -RRB- cord-294854-rvrgcugn 131 39 Acute acute JJ cord-294854-rvrgcugn 131 40 Respiratory Respiratory NNP cord-294854-rvrgcugn 131 41 Distress Distress NNP cord-294854-rvrgcugn 131 42 Syndrome Syndrome NNP cord-294854-rvrgcugn 131 43 patients patient NNS cord-294854-rvrgcugn 131 44 with with IN cord-294854-rvrgcugn 131 45 Tocilizumab tocilizumab JJ cord-294854-rvrgcugn 131 46 administration administration NN cord-294854-rvrgcugn 131 47 Rational rational JJ cord-294854-rvrgcugn 131 48 Use Use NNP cord-294854-rvrgcugn 131 49 of of IN cord-294854-rvrgcugn 131 50 Tocilizumab Tocilizumab NNP cord-294854-rvrgcugn 131 51 in in IN cord-294854-rvrgcugn 131 52 the the DT cord-294854-rvrgcugn 131 53 Treatment Treatment NNP cord-294854-rvrgcugn 131 54 of of IN cord-294854-rvrgcugn 131 55 Novel Novel NNP cord-294854-rvrgcugn 131 56 Coronavirus Coronavirus NNP cord-294854-rvrgcugn 131 57 Pneumonia Pneumonia NNP cord-294854-rvrgcugn 132 1 The the DT cord-294854-rvrgcugn 132 2 Society Society NNP cord-294854-rvrgcugn 132 3 for for IN cord-294854-rvrgcugn 132 4 Immunotherapy Immunotherapy NNP cord-294854-rvrgcugn 132 5 of of IN cord-294854-rvrgcugn 132 6 Cancer Cancer NNP cord-294854-rvrgcugn 132 7 perspective perspective NN cord-294854-rvrgcugn 132 8 on on IN cord-294854-rvrgcugn 132 9 regulation regulation NN cord-294854-rvrgcugn 132 10 of of IN cord-294854-rvrgcugn 132 11 interleukin-6 interleukin-6 NNP cord-294854-rvrgcugn 132 12 signaling signal VBG cord-294854-rvrgcugn 132 13 in in IN cord-294854-rvrgcugn 132 14 COVID-19-related covid-19-related JJ cord-294854-rvrgcugn 132 15 systemic systemic JJ cord-294854-rvrgcugn 132 16 inflammatory inflammatory JJ cord-294854-rvrgcugn 132 17 response response NN cord-294854-rvrgcugn 132 18 BSR BSR NNP cord-294854-rvrgcugn 132 19 guidance guidance NN cord-294854-rvrgcugn 132 20 for for IN cord-294854-rvrgcugn 132 21 patients patient NNS cord-294854-rvrgcugn 132 22 during during IN cord-294854-rvrgcugn 132 23 Covid-19 covid-19 JJ cord-294854-rvrgcugn 132 24 outbreak outbreak NN cord-294854-rvrgcugn 132 25 ACR ACR NNP cord-294854-rvrgcugn 132 26 guidance guidance NN cord-294854-rvrgcugn 132 27 for for IN cord-294854-rvrgcugn 132 28 patients patient NNS cord-294854-rvrgcugn 132 29 during during IN cord-294854-rvrgcugn 132 30 Covid-19 covid-19 JJ cord-294854-rvrgcugn 132 31 outbreak outbreak NN cord-294854-rvrgcugn 132 32 2020 2020 CD cord-294854-rvrgcugn 132 33 Australian Australian NNP cord-294854-rvrgcugn 132 34 Rheumatology Rheumatology NNP cord-294854-rvrgcugn 132 35 Association Association NNP cord-294854-rvrgcugn 132 36 guidance guidance NN cord-294854-rvrgcugn 132 37 for for IN cord-294854-rvrgcugn 132 38 patients patient NNS cord-294854-rvrgcugn 132 39 during during IN cord-294854-rvrgcugn 132 40 Covid-19 covid-19 JJ cord-294854-rvrgcugn 132 41 outbreak outbreak NN cord-294854-rvrgcugn 132 42 2020 2020 CD cord-294854-rvrgcugn 133 1 The the DT cord-294854-rvrgcugn 133 2 immunomodulatory immunomodulatory JJ cord-294854-rvrgcugn 133 3 function function NN cord-294854-rvrgcugn 133 4 of of IN cord-294854-rvrgcugn 133 5 mesenchymal mesenchymal JJ cord-294854-rvrgcugn 133 6 stem stem NN cord-294854-rvrgcugn 133 7 cells cell NNS cord-294854-rvrgcugn 133 8 : : : cord-294854-rvrgcugn 133 9 mode mode NN cord-294854-rvrgcugn 133 10 of of IN cord-294854-rvrgcugn 133 11 action action NN cord-294854-rvrgcugn 133 12 and and CC cord-294854-rvrgcugn 133 13 pathways pathway NNS cord-294854-rvrgcugn 133 14 Clinical clinical JJ cord-294854-rvrgcugn 133 15 study study NN cord-294854-rvrgcugn 133 16 of of IN cord-294854-rvrgcugn 133 17 mesenchymal mesenchymal JJ cord-294854-rvrgcugn 133 18 stem stem NN cord-294854-rvrgcugn 133 19 cell cell NN cord-294854-rvrgcugn 133 20 treating treat VBG cord-294854-rvrgcugn 133 21 acute acute JJ cord-294854-rvrgcugn 133 22 respiratory respiratory JJ cord-294854-rvrgcugn 133 23 distress distress NN cord-294854-rvrgcugn 133 24 syndrome syndrome NN cord-294854-rvrgcugn 133 25 induced induce VBN cord-294854-rvrgcugn 133 26 by by IN cord-294854-rvrgcugn 133 27 epidemic epidemic NN cord-294854-rvrgcugn 133 28 Influenza Influenza NNP cord-294854-rvrgcugn 133 29 A A NNP cord-294854-rvrgcugn 133 30 ( ( -LRB- cord-294854-rvrgcugn 133 31 H7N9 H7N9 NNP cord-294854-rvrgcugn 133 32 ) ) -RRB- cord-294854-rvrgcugn 133 33 infection infection NN cord-294854-rvrgcugn 133 34 , , , cord-294854-rvrgcugn 133 35 a a DT cord-294854-rvrgcugn 133 36 hint hint NN cord-294854-rvrgcugn 133 37 for for IN cord-294854-rvrgcugn 133 38 COVID-19 covid-19 JJ cord-294854-rvrgcugn 133 39 treatment treatment NN cord-294854-rvrgcugn 133 40 Transplantation transplantation NN cord-294854-rvrgcugn 133 41 of of IN cord-294854-rvrgcugn 133 42 ACE2(- ace2(- NN cord-294854-rvrgcugn 133 43 ) ) -RRB- cord-294854-rvrgcugn 134 1 Mesenchymal Mesenchymal NNP cord-294854-rvrgcugn 134 2 Stem Stem NNP cord-294854-rvrgcugn 134 3 Cells cell NNS cord-294854-rvrgcugn 134 4 Improves improve VBZ cord-294854-rvrgcugn 134 5 the the DT cord-294854-rvrgcugn 134 6 Outcome outcome NN cord-294854-rvrgcugn 134 7 of of IN cord-294854-rvrgcugn 134 8 Patients patient NNS cord-294854-rvrgcugn 134 9 with with IN cord-294854-rvrgcugn 134 10 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 134 11 Pneumonia Pneumonia NNP cord-294854-rvrgcugn 134 12 Interleukin-1 Interleukin-1 NNP cord-294854-rvrgcugn 134 13 blockade blockade NN cord-294854-rvrgcugn 134 14 with with IN cord-294854-rvrgcugn 134 15 high high JJ cord-294854-rvrgcugn 134 16 - - HYPH cord-294854-rvrgcugn 134 17 dose dose NN cord-294854-rvrgcugn 134 18 anakinra anakinra NN cord-294854-rvrgcugn 134 19 in in IN cord-294854-rvrgcugn 134 20 patients patient NNS cord-294854-rvrgcugn 134 21 with with IN cord-294854-rvrgcugn 134 22 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 134 23 , , , cord-294854-rvrgcugn 134 24 acute acute JJ cord-294854-rvrgcugn 134 25 respiratory respiratory JJ cord-294854-rvrgcugn 134 26 distress distress NN cord-294854-rvrgcugn 134 27 syndrome syndrome NN cord-294854-rvrgcugn 134 28 , , , cord-294854-rvrgcugn 134 29 and and CC cord-294854-rvrgcugn 134 30 hyperinflammation hyperinflammation NN cord-294854-rvrgcugn 134 31 : : : cord-294854-rvrgcugn 134 32 a a DT cord-294854-rvrgcugn 134 33 retrospective retrospective JJ cord-294854-rvrgcugn 134 34 cohort cohort NN cord-294854-rvrgcugn 134 35 study study NN cord-294854-rvrgcugn 134 36 Ribavirin Ribavirin NNP cord-294854-rvrgcugn 134 37 and and CC cord-294854-rvrgcugn 134 38 Interferon Interferon NNP cord-294854-rvrgcugn 134 39 Therapy Therapy NNP cord-294854-rvrgcugn 134 40 for for IN cord-294854-rvrgcugn 134 41 Critically Critically NNP cord-294854-rvrgcugn 134 42 Ill Ill NNP cord-294854-rvrgcugn 134 43 Patients patient NNS cord-294854-rvrgcugn 134 44 With with IN cord-294854-rvrgcugn 134 45 Middle Middle NNP cord-294854-rvrgcugn 134 46 East East NNP cord-294854-rvrgcugn 134 47 Respiratory Respiratory NNP cord-294854-rvrgcugn 134 48 Syndrome Syndrome NNP cord-294854-rvrgcugn 134 49 : : : cord-294854-rvrgcugn 134 50 A a DT cord-294854-rvrgcugn 134 51 Multicenter Multicenter NNP cord-294854-rvrgcugn 134 52 Observational Observational NNP cord-294854-rvrgcugn 134 53 Study Study NNP cord-294854-rvrgcugn 134 54 Baricitinib Baricitinib NNP cord-294854-rvrgcugn 134 55 therapy therapy NN cord-294854-rvrgcugn 134 56 in in IN cord-294854-rvrgcugn 134 57 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 134 58 : : : cord-294854-rvrgcugn 135 1 A a DT cord-294854-rvrgcugn 135 2 pilot pilot NN cord-294854-rvrgcugn 135 3 study study NN cord-294854-rvrgcugn 135 4 on on IN cord-294854-rvrgcugn 135 5 safety safety NN cord-294854-rvrgcugn 135 6 and and CC cord-294854-rvrgcugn 135 7 clinical clinical JJ cord-294854-rvrgcugn 135 8 impact impact NN cord-294854-rvrgcugn 135 9 . . . cord-294854-rvrgcugn 136 1 The the DT cord-294854-rvrgcugn 136 2 Journal Journal NNP cord-294854-rvrgcugn 136 3 of of IN cord-294854-rvrgcugn 136 4 infection infection NN cord-294854-rvrgcugn 136 5 Baricitinib Baricitinib NNP cord-294854-rvrgcugn 136 6 as as IN cord-294854-rvrgcugn 136 7 potential potential JJ cord-294854-rvrgcugn 136 8 treatment treatment NN cord-294854-rvrgcugn 136 9 for for IN cord-294854-rvrgcugn 136 10 2019-nCoV 2019-ncov CD cord-294854-rvrgcugn 136 11 acute acute JJ cord-294854-rvrgcugn 136 12 respiratory respiratory JJ cord-294854-rvrgcugn 136 13 disease disease NN cord-294854-rvrgcugn 137 1 The the DT cord-294854-rvrgcugn 137 2 cytokine cytokine NN cord-294854-rvrgcugn 137 3 storm storm NN cord-294854-rvrgcugn 137 4 of of IN cord-294854-rvrgcugn 137 5 severe severe JJ cord-294854-rvrgcugn 137 6 influenza influenza NN cord-294854-rvrgcugn 137 7 and and CC cord-294854-rvrgcugn 137 8 development development NN cord-294854-rvrgcugn 137 9 of of IN cord-294854-rvrgcugn 137 10 immunomodulatory immunomodulatory NNP cord-294854-rvrgcugn 137 11 therapy therapy NN cord-294854-rvrgcugn 137 12 Epidemiological epidemiological JJ cord-294854-rvrgcugn 137 13 and and CC cord-294854-rvrgcugn 137 14 clinical clinical JJ cord-294854-rvrgcugn 137 15 characteristics characteristic NNS cord-294854-rvrgcugn 137 16 of of IN cord-294854-rvrgcugn 137 17 99 99 CD cord-294854-rvrgcugn 137 18 cases case NNS cord-294854-rvrgcugn 137 19 of of IN cord-294854-rvrgcugn 137 20 2019 2019 CD cord-294854-rvrgcugn 137 21 novel novel JJ cord-294854-rvrgcugn 137 22 coronavirus coronavirus NN cord-294854-rvrgcugn 137 23 pneumonia pneumonia NN cord-294854-rvrgcugn 137 24 in in IN cord-294854-rvrgcugn 137 25 Wuhan Wuhan NNP cord-294854-rvrgcugn 137 26 , , , cord-294854-rvrgcugn 137 27 China China NNP cord-294854-rvrgcugn 137 28 : : : cord-294854-rvrgcugn 137 29 a a DT cord-294854-rvrgcugn 137 30 descriptive descriptive JJ cord-294854-rvrgcugn 137 31 study study NN cord-294854-rvrgcugn 137 32 Immunomodulatory Immunomodulatory NNP cord-294854-rvrgcugn 137 33 therapy therapy NN cord-294854-rvrgcugn 137 34 for for IN cord-294854-rvrgcugn 137 35 the the DT cord-294854-rvrgcugn 137 36 management management NN cord-294854-rvrgcugn 137 37 of of IN cord-294854-rvrgcugn 137 38 severe severe JJ cord-294854-rvrgcugn 137 39 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 137 40 . . . cord-294854-rvrgcugn 138 1 Beyond beyond IN cord-294854-rvrgcugn 138 2 the the DT cord-294854-rvrgcugn 138 3 anti anti JJ cord-294854-rvrgcugn 138 4 - - JJ cord-294854-rvrgcugn 138 5 viral viral JJ cord-294854-rvrgcugn 138 6 therapy therapy NN cord-294854-rvrgcugn 138 7 : : : cord-294854-rvrgcugn 138 8 A a DT cord-294854-rvrgcugn 138 9 comprehensive comprehensive JJ cord-294854-rvrgcugn 138 10 review review NN cord-294854-rvrgcugn 139 1 The the DT cord-294854-rvrgcugn 139 2 effectiveness effectiveness NN cord-294854-rvrgcugn 139 3 of of IN cord-294854-rvrgcugn 139 4 convalescent convalescent JJ cord-294854-rvrgcugn 139 5 plasma plasma NN cord-294854-rvrgcugn 139 6 and and CC cord-294854-rvrgcugn 139 7 hyperimmune hyperimmune NNP cord-294854-rvrgcugn 139 8 immunoglobulin immunoglobulin NN cord-294854-rvrgcugn 139 9 for for IN cord-294854-rvrgcugn 139 10 the the DT cord-294854-rvrgcugn 139 11 treatment treatment NN cord-294854-rvrgcugn 139 12 of of IN cord-294854-rvrgcugn 139 13 severe severe JJ cord-294854-rvrgcugn 139 14 acute acute JJ cord-294854-rvrgcugn 139 15 respiratory respiratory JJ cord-294854-rvrgcugn 139 16 infections infection NNS cord-294854-rvrgcugn 139 17 of of IN cord-294854-rvrgcugn 139 18 viral viral JJ cord-294854-rvrgcugn 139 19 etiology etiology NN cord-294854-rvrgcugn 139 20 : : : cord-294854-rvrgcugn 139 21 a a DT cord-294854-rvrgcugn 139 22 systematic systematic JJ cord-294854-rvrgcugn 139 23 review review NN cord-294854-rvrgcugn 139 24 and and CC cord-294854-rvrgcugn 139 25 exploratory exploratory JJ cord-294854-rvrgcugn 139 26 meta meta JJ cord-294854-rvrgcugn 139 27 - - HYPH cord-294854-rvrgcugn 139 28 analysis analysis NN cord-294854-rvrgcugn 139 29 Convalescent convalescent JJ cord-294854-rvrgcugn 139 30 plasma plasma NN cord-294854-rvrgcugn 139 31 treatment treatment NN cord-294854-rvrgcugn 139 32 reduced reduce VBN cord-294854-rvrgcugn 139 33 mortality mortality NN cord-294854-rvrgcugn 139 34 in in IN cord-294854-rvrgcugn 139 35 patients patient NNS cord-294854-rvrgcugn 139 36 with with IN cord-294854-rvrgcugn 139 37 severe severe JJ cord-294854-rvrgcugn 139 38 pandemic pandemic NN cord-294854-rvrgcugn 139 39 influenza influenza NN cord-294854-rvrgcugn 139 40 A a NN cord-294854-rvrgcugn 139 41 ( ( -LRB- cord-294854-rvrgcugn 139 42 H1N1 H1N1 NNP cord-294854-rvrgcugn 139 43 ) ) -RRB- cord-294854-rvrgcugn 139 44 2009 2009 CD cord-294854-rvrgcugn 139 45 virus virus NN cord-294854-rvrgcugn 139 46 infection infection NN cord-294854-rvrgcugn 140 1 We -PRON- PRP cord-294854-rvrgcugn 140 2 thank thank VBP cord-294854-rvrgcugn 140 3 all all PDT cord-294854-rvrgcugn 140 4 the the DT cord-294854-rvrgcugn 140 5 doctors doctor NNS cord-294854-rvrgcugn 140 6 and and CC cord-294854-rvrgcugn 140 7 nurses nurse NNS cord-294854-rvrgcugn 140 8 who who WP cord-294854-rvrgcugn 140 9 have have VBP cord-294854-rvrgcugn 140 10 bravely bravely RB cord-294854-rvrgcugn 140 11 fought fight VBN cord-294854-rvrgcugn 140 12 the the DT cord-294854-rvrgcugn 140 13 virus virus NN cord-294854-rvrgcugn 140 14 during during IN cord-294854-rvrgcugn 140 15 the the DT cord-294854-rvrgcugn 140 16 COVID-19 COVID-19 NNP cord-294854-rvrgcugn 140 17 pandemic pandemic NN cord-294854-rvrgcugn 140 18 . . . cord-294854-rvrgcugn 141 1 The the DT cord-294854-rvrgcugn 141 2 authors author NNS cord-294854-rvrgcugn 141 3 declare declare VBP cord-294854-rvrgcugn 141 4 no no DT cord-294854-rvrgcugn 141 5 conflicts conflict NNS cord-294854-rvrgcugn 141 6 of of IN cord-294854-rvrgcugn 141 7 interest interest NN cord-294854-rvrgcugn 141 8 . . . cord-294854-rvrgcugn 142 1 1 1 CD cord-294854-rvrgcugn 142 2 _SP