id	sid	tid	token	lemma	pos
cord-288670-1vlowf2n	1	1	key	key	NN
cord-288670-1vlowf2n	1	2	:	:	:
cord-288670-1vlowf2n	2	1	cord-288670	cord-288670	NNS
cord-288670-1vlowf2n	2	2	-	-	HYPH
cord-288670-1vlowf2n	2	3	1vlowf2n	1vlowf2n	CD
cord-288670-1vlowf2n	2	4	authors	author	NNS
cord-288670-1vlowf2n	2	5	:	:	:
cord-288670-1vlowf2n	2	6	Yang	Yang	NNP
cord-288670-1vlowf2n	2	7	,	,	,
cord-288670-1vlowf2n	2	8	Naidi	Naidi	NNP
cord-288670-1vlowf2n	2	9	;	;	:
cord-288670-1vlowf2n	2	10	Shen	Shen	NNP
cord-288670-1vlowf2n	2	11	,	,	,
cord-288670-1vlowf2n	2	12	Han	Han	NNP
cord-288670-1vlowf2n	2	13	-	-	HYPH
cord-288670-1vlowf2n	2	14	Ming	Ming	NNP
cord-288670-1vlowf2n	2	15	title	title	NN
cord-288670-1vlowf2n	2	16	:	:	:
cord-288670-1vlowf2n	3	1	Targeting	target	VBG
cord-288670-1vlowf2n	3	2	the	the	DT
cord-288670-1vlowf2n	3	3	Endocytic	Endocytic	NNP
cord-288670-1vlowf2n	3	4	Pathway	Pathway	NNP
cord-288670-1vlowf2n	3	5	and	and	CC
cord-288670-1vlowf2n	3	6	Autophagy	Autophagy	NNP
cord-288670-1vlowf2n	3	7	Process	Process	NNP
cord-288670-1vlowf2n	3	8	as	as	IN
cord-288670-1vlowf2n	3	9	a	a	DT
cord-288670-1vlowf2n	3	10	Novel	Novel	NNP
cord-288670-1vlowf2n	3	11	Therapeutic	Therapeutic	NNP
cord-288670-1vlowf2n	3	12	Strategy	Strategy	NNP
cord-288670-1vlowf2n	3	13	in	in	IN
cord-288670-1vlowf2n	3	14	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	3	15	date	date	NN
cord-288670-1vlowf2n	3	16	:	:	:
cord-288670-1vlowf2n	3	17	2020	2020	CD
cord-288670-1vlowf2n	3	18	-	-	HYPH
cord-288670-1vlowf2n	3	19	03	03	CD
cord-288670-1vlowf2n	3	20	-	-	SYM
cord-288670-1vlowf2n	3	21	15	15	CD
cord-288670-1vlowf2n	3	22	journal	journal	NN
cord-288670-1vlowf2n	3	23	:	:	:
cord-288670-1vlowf2n	4	1	Int	Int	NNP
cord-288670-1vlowf2n	4	2	J	J	NNP
cord-288670-1vlowf2n	4	3	Biol	Biol	NNP
cord-288670-1vlowf2n	5	1	Sci	Sci	NNP
cord-288670-1vlowf2n	5	2	DOI	DOI	NNP
cord-288670-1vlowf2n	6	1	:	:	:
cord-288670-1vlowf2n	6	2	10.7150	10.7150	CD
cord-288670-1vlowf2n	6	3	/	/	SYM
cord-288670-1vlowf2n	6	4	ijbs.45498	ijbs.45498	NNP
cord-288670-1vlowf2n	6	5	sha	sha	NNP
cord-288670-1vlowf2n	6	6	:	:	:
cord-288670-1vlowf2n	7	1	cb41121acc53429b7c16b8351051a42a3066757a	cb41121acc53429b7c16b8351051a42a3066757a	NNP
cord-288670-1vlowf2n	7	2	doc_id	doc_id	CD
cord-288670-1vlowf2n	7	3	:	:	:
cord-288670-1vlowf2n	7	4	288670	288670	CD
cord-288670-1vlowf2n	7	5	cord_uid	cord_uid	NNS
cord-288670-1vlowf2n	7	6	:	:	:
cord-288670-1vlowf2n	8	1	1vlowf2n	1vlowf2n	LS
cord-288670-1vlowf2n	8	2	Coronaviruses	Coronaviruses	NNP
cord-288670-1vlowf2n	8	3	(	(	-LRB-
cord-288670-1vlowf2n	8	4	CoVs	CoVs	NNP
cord-288670-1vlowf2n	8	5	)	)	-RRB-
cord-288670-1vlowf2n	8	6	are	be	VBP
cord-288670-1vlowf2n	8	7	a	a	DT
cord-288670-1vlowf2n	8	8	group	group	NN
cord-288670-1vlowf2n	8	9	of	of	IN
cord-288670-1vlowf2n	8	10	enveloped	envelop	VBN
cord-288670-1vlowf2n	8	11	,	,	,
cord-288670-1vlowf2n	8	12	single	single	RB
cord-288670-1vlowf2n	8	13	-	-	HYPH
cord-288670-1vlowf2n	8	14	stranded	strand	VBN
cord-288670-1vlowf2n	8	15	positive	positive	JJ
cord-288670-1vlowf2n	8	16	genomic	genomic	JJ
cord-288670-1vlowf2n	8	17	RNA	rna	NN
cord-288670-1vlowf2n	8	18	viruses	virus	NNS
cord-288670-1vlowf2n	8	19	and	and	CC
cord-288670-1vlowf2n	8	20	some	some	DT
cord-288670-1vlowf2n	8	21	of	of	IN
cord-288670-1vlowf2n	8	22	them	-PRON-	PRP
cord-288670-1vlowf2n	8	23	are	be	VBP
cord-288670-1vlowf2n	8	24	known	know	VBN
cord-288670-1vlowf2n	8	25	to	to	TO
cord-288670-1vlowf2n	8	26	cause	cause	VB
cord-288670-1vlowf2n	8	27	severe	severe	JJ
cord-288670-1vlowf2n	8	28	respiratory	respiratory	JJ
cord-288670-1vlowf2n	8	29	diseases	disease	NNS
cord-288670-1vlowf2n	8	30	in	in	IN
cord-288670-1vlowf2n	8	31	human	human	NN
cord-288670-1vlowf2n	8	32	,	,	,
cord-288670-1vlowf2n	8	33	including	include	VBG
cord-288670-1vlowf2n	8	34	Severe	severe	JJ
cord-288670-1vlowf2n	8	35	Acute	acute	JJ
cord-288670-1vlowf2n	8	36	Respiratory	Respiratory	NNP
cord-288670-1vlowf2n	8	37	Syndrome	Syndrome	NNP
cord-288670-1vlowf2n	8	38	(	(	-LRB-
cord-288670-1vlowf2n	8	39	SARS	SARS	NNP
cord-288670-1vlowf2n	8	40	)	)	-RRB-
cord-288670-1vlowf2n	8	41	,	,	,
cord-288670-1vlowf2n	8	42	Middle	Middle	NNP
cord-288670-1vlowf2n	8	43	East	East	NNP
cord-288670-1vlowf2n	8	44	Respiratory	Respiratory	NNP
cord-288670-1vlowf2n	8	45	Syndrome	Syndrome	NNP
cord-288670-1vlowf2n	8	46	(	(	-LRB-
cord-288670-1vlowf2n	8	47	MERS	MERS	NNP
cord-288670-1vlowf2n	8	48	)	)	-RRB-
cord-288670-1vlowf2n	8	49	and	and	CC
cord-288670-1vlowf2n	8	50	the	the	DT
cord-288670-1vlowf2n	8	51	ongoing	ongoing	JJ
cord-288670-1vlowf2n	8	52	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	8	53	disease-19	disease-19	,
cord-288670-1vlowf2n	8	54	(	(	-LRB-
cord-288670-1vlowf2n	8	55	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	8	56	)	)	-RRB-
cord-288670-1vlowf2n	8	57	.	.	.
cord-288670-1vlowf2n	9	1	One	one	CD
cord-288670-1vlowf2n	9	2	key	key	JJ
cord-288670-1vlowf2n	9	3	element	element	NN
cord-288670-1vlowf2n	9	4	in	in	IN
cord-288670-1vlowf2n	9	5	viral	viral	JJ
cord-288670-1vlowf2n	9	6	infection	infection	NN
cord-288670-1vlowf2n	9	7	is	be	VBZ
cord-288670-1vlowf2n	9	8	the	the	DT
cord-288670-1vlowf2n	9	9	process	process	NN
cord-288670-1vlowf2n	9	10	of	of	IN
cord-288670-1vlowf2n	9	11	viral	viral	JJ
cord-288670-1vlowf2n	9	12	entry	entry	NN
cord-288670-1vlowf2n	9	13	into	into	IN
cord-288670-1vlowf2n	9	14	the	the	DT
cord-288670-1vlowf2n	9	15	host	host	NN
cord-288670-1vlowf2n	9	16	cells	cell	NNS
cord-288670-1vlowf2n	9	17	.	.	.
cord-288670-1vlowf2n	10	1	In	in	IN
cord-288670-1vlowf2n	10	2	the	the	DT
cord-288670-1vlowf2n	10	3	last	last	JJ
cord-288670-1vlowf2n	10	4	two	two	CD
cord-288670-1vlowf2n	10	5	decades	decade	NNS
cord-288670-1vlowf2n	10	6	,	,	,
cord-288670-1vlowf2n	10	7	there	there	EX
cord-288670-1vlowf2n	10	8	is	be	VBZ
cord-288670-1vlowf2n	10	9	increasing	increase	VBG
cord-288670-1vlowf2n	10	10	understanding	understanding	NN
cord-288670-1vlowf2n	10	11	on	on	IN
cord-288670-1vlowf2n	10	12	the	the	DT
cord-288670-1vlowf2n	10	13	importance	importance	NN
cord-288670-1vlowf2n	10	14	of	of	IN
cord-288670-1vlowf2n	10	15	the	the	DT
cord-288670-1vlowf2n	10	16	endocytic	endocytic	JJ
cord-288670-1vlowf2n	10	17	pathway	pathway	NN
cord-288670-1vlowf2n	10	18	and	and	CC
cord-288670-1vlowf2n	10	19	the	the	DT
cord-288670-1vlowf2n	10	20	autophagy	autophagy	NN
cord-288670-1vlowf2n	10	21	process	process	NN
cord-288670-1vlowf2n	10	22	in	in	IN
cord-288670-1vlowf2n	10	23	viral	viral	JJ
cord-288670-1vlowf2n	10	24	entry	entry	NN
cord-288670-1vlowf2n	10	25	and	and	CC
cord-288670-1vlowf2n	10	26	replication	replication	NN
cord-288670-1vlowf2n	10	27	.	.	.
cord-288670-1vlowf2n	11	1	As	as	IN
cord-288670-1vlowf2n	11	2	a	a	DT
cord-288670-1vlowf2n	11	3	result	result	NN
cord-288670-1vlowf2n	11	4	,	,	,
cord-288670-1vlowf2n	11	5	the	the	DT
cord-288670-1vlowf2n	11	6	endocytic	endocytic	JJ
cord-288670-1vlowf2n	11	7	pathway	pathway	NN
cord-288670-1vlowf2n	11	8	including	include	VBG
cord-288670-1vlowf2n	11	9	endosome	endosome	NN
cord-288670-1vlowf2n	11	10	and	and	CC
cord-288670-1vlowf2n	11	11	lysosome	lysosome	NN
cord-288670-1vlowf2n	11	12	has	have	VBZ
cord-288670-1vlowf2n	11	13	become	become	VBN
cord-288670-1vlowf2n	11	14	important	important	JJ
cord-288670-1vlowf2n	11	15	targets	target	NNS
cord-288670-1vlowf2n	11	16	for	for	IN
cord-288670-1vlowf2n	11	17	development	development	NN
cord-288670-1vlowf2n	11	18	of	of	IN
cord-288670-1vlowf2n	11	19	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	11	20	strategies	strategy	NNS
cord-288670-1vlowf2n	11	21	in	in	IN
cord-288670-1vlowf2n	11	22	combating	combat	VBG
cord-288670-1vlowf2n	11	23	diseases	disease	NNS
cord-288670-1vlowf2n	11	24	caused	cause	VBN
cord-288670-1vlowf2n	11	25	by	by	IN
cord-288670-1vlowf2n	11	26	CoVs	CoVs	NNP
cord-288670-1vlowf2n	11	27	.	.	.
cord-288670-1vlowf2n	12	1	In	in	IN
cord-288670-1vlowf2n	12	2	this	this	DT
cord-288670-1vlowf2n	12	3	mini	mini	JJ
cord-288670-1vlowf2n	12	4	-	-	NN
cord-288670-1vlowf2n	12	5	review	review	NN
cord-288670-1vlowf2n	12	6	,	,	,
cord-288670-1vlowf2n	12	7	we	-PRON-	PRP
cord-288670-1vlowf2n	12	8	will	will	MD
cord-288670-1vlowf2n	12	9	focus	focus	VB
cord-288670-1vlowf2n	12	10	on	on	IN
cord-288670-1vlowf2n	12	11	the	the	DT
cord-288670-1vlowf2n	12	12	importance	importance	NN
cord-288670-1vlowf2n	12	13	of	of	IN
cord-288670-1vlowf2n	12	14	the	the	DT
cord-288670-1vlowf2n	12	15	endocytic	endocytic	JJ
cord-288670-1vlowf2n	12	16	pathway	pathway	NN
cord-288670-1vlowf2n	12	17	as	as	RB
cord-288670-1vlowf2n	12	18	well	well	RB
cord-288670-1vlowf2n	12	19	as	as	IN
cord-288670-1vlowf2n	12	20	the	the	DT
cord-288670-1vlowf2n	12	21	autophagy	autophagy	NN
cord-288670-1vlowf2n	12	22	process	process	NN
cord-288670-1vlowf2n	12	23	in	in	IN
cord-288670-1vlowf2n	12	24	viral	viral	JJ
cord-288670-1vlowf2n	12	25	infection	infection	NN
cord-288670-1vlowf2n	12	26	of	of	IN
cord-288670-1vlowf2n	12	27	several	several	JJ
cord-288670-1vlowf2n	12	28	pathogenic	pathogenic	JJ
cord-288670-1vlowf2n	12	29	CoVs	CoVs	NNP
cord-288670-1vlowf2n	12	30	inclusive	inclusive	JJ
cord-288670-1vlowf2n	12	31	of	of	IN
cord-288670-1vlowf2n	12	32	SARS	SARS	NNP
cord-288670-1vlowf2n	12	33	-	-	HYPH
cord-288670-1vlowf2n	12	34	CoV	CoV	NNP
cord-288670-1vlowf2n	12	35	,	,	,
cord-288670-1vlowf2n	12	36	MERS	MERS	NNP
cord-288670-1vlowf2n	12	37	-	-	HYPH
cord-288670-1vlowf2n	12	38	CoV	CoV	NNP
cord-288670-1vlowf2n	12	39	and	and	CC
cord-288670-1vlowf2n	12	40	the	the	DT
cord-288670-1vlowf2n	12	41	new	new	JJ
cord-288670-1vlowf2n	12	42	CoV	cov	NN
cord-288670-1vlowf2n	12	43	named	name	VBN
cord-288670-1vlowf2n	12	44	as	as	IN
cord-288670-1vlowf2n	12	45	severe	severe	JJ
cord-288670-1vlowf2n	12	46	acute	acute	JJ
cord-288670-1vlowf2n	12	47	respiratory	respiratory	JJ
cord-288670-1vlowf2n	12	48	syndrome	syndrome	NN
cord-288670-1vlowf2n	12	49	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	12	50	2	2	CD
cord-288670-1vlowf2n	12	51	(	(	-LRB-
cord-288670-1vlowf2n	12	52	SARS	SARS	NNP
cord-288670-1vlowf2n	12	53	-	-	HYPH
cord-288670-1vlowf2n	12	54	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	12	55	)	)	-RRB-
cord-288670-1vlowf2n	12	56	,	,	,
cord-288670-1vlowf2n	12	57	and	and	CC
cord-288670-1vlowf2n	12	58	discuss	discuss	VB
cord-288670-1vlowf2n	12	59	the	the	DT
cord-288670-1vlowf2n	12	60	development	development	NN
cord-288670-1vlowf2n	12	61	of	of	IN
cord-288670-1vlowf2n	12	62	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	12	63	agents	agent	NNS
cord-288670-1vlowf2n	12	64	by	by	IN
cord-288670-1vlowf2n	12	65	targeting	target	VBG
cord-288670-1vlowf2n	12	66	these	these	DT
cord-288670-1vlowf2n	12	67	processes	process	NNS
cord-288670-1vlowf2n	12	68	.	.	.
cord-288670-1vlowf2n	13	1	Such	such	JJ
cord-288670-1vlowf2n	13	2	knowledge	knowledge	NN
cord-288670-1vlowf2n	13	3	will	will	MD
cord-288670-1vlowf2n	13	4	provide	provide	VB
cord-288670-1vlowf2n	13	5	important	important	JJ
cord-288670-1vlowf2n	13	6	clues	clue	NNS
cord-288670-1vlowf2n	13	7	for	for	IN
cord-288670-1vlowf2n	13	8	control	control	NN
cord-288670-1vlowf2n	13	9	of	of	IN
cord-288670-1vlowf2n	13	10	the	the	DT
cord-288670-1vlowf2n	13	11	ongoing	ongoing	JJ
cord-288670-1vlowf2n	13	12	epidemic	epidemic	NN
cord-288670-1vlowf2n	13	13	of	of	IN
cord-288670-1vlowf2n	13	14	SARS	SARS	NNP
cord-288670-1vlowf2n	13	15	-	-	HYPH
cord-288670-1vlowf2n	13	16	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	13	17	infection	infection	NN
cord-288670-1vlowf2n	13	18	and	and	CC
cord-288670-1vlowf2n	13	19	treatment	treatment	NN
cord-288670-1vlowf2n	13	20	of	of	IN
cord-288670-1vlowf2n	14	1	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	14	2	.	.	.
cord-288670-1vlowf2n	15	1	Coronaviruses	Coronaviruses	NNP
cord-288670-1vlowf2n	15	2	(	(	-LRB-
cord-288670-1vlowf2n	15	3	CoVs	CoVs	NNP
cord-288670-1vlowf2n	15	4	)	)	-RRB-
cord-288670-1vlowf2n	15	5	are	be	VBP
cord-288670-1vlowf2n	15	6	enveloped	envelop	VBN
cord-288670-1vlowf2n	15	7	viruses	virus	NNS
cord-288670-1vlowf2n	15	8	with	with	IN
cord-288670-1vlowf2n	15	9	a	a	DT
cord-288670-1vlowf2n	15	10	long	long	JJ
cord-288670-1vlowf2n	15	11	single	single	RB
cord-288670-1vlowf2n	15	12	-	-	HYPH
cord-288670-1vlowf2n	15	13	stranded	strand	VBN
cord-288670-1vlowf2n	15	14	RNA	RNA	NNP
cord-288670-1vlowf2n	15	15	ranging	range	VBG
cord-288670-1vlowf2n	15	16	from	from	IN
cord-288670-1vlowf2n	15	17	26	26	CD
cord-288670-1vlowf2n	15	18	to	to	TO
cord-288670-1vlowf2n	15	19	32	32	CD
cord-288670-1vlowf2n	15	20	kilobases	kilobase	NNS
cord-288670-1vlowf2n	15	21	(	(	-LRB-
cord-288670-1vlowf2n	15	22	kb	kb	NNP
cord-288670-1vlowf2n	15	23	)	)	-RRB-
cord-288670-1vlowf2n	15	24	in	in	IN
cord-288670-1vlowf2n	15	25	size	size	NN
cord-288670-1vlowf2n	15	26	[	[	-LRB-
cord-288670-1vlowf2n	15	27	1	1	CD
cord-288670-1vlowf2n	15	28	]	]	-RRB-
cord-288670-1vlowf2n	15	29	.	.	.
cord-288670-1vlowf2n	16	1	CoVs	CoVs	NNP
cord-288670-1vlowf2n	16	2	belong	belong	VBP
cord-288670-1vlowf2n	16	3	to	to	IN
cord-288670-1vlowf2n	16	4	the	the	DT
cord-288670-1vlowf2n	16	5	family	family	NN
cord-288670-1vlowf2n	16	6	Coronaviridae	Coronaviridae	NNP
cord-288670-1vlowf2n	16	7	in	in	IN
cord-288670-1vlowf2n	16	8	the	the	DT
cord-288670-1vlowf2n	16	9	order	order	NN
cord-288670-1vlowf2n	16	10	Nidovirales	Nidovirales	NNP
cord-288670-1vlowf2n	16	11	,	,	,
cord-288670-1vlowf2n	16	12	and	and	CC
cord-288670-1vlowf2n	16	13	have	have	VBP
cord-288670-1vlowf2n	16	14	been	be	VBN
cord-288670-1vlowf2n	16	15	organised	organise	VBN
cord-288670-1vlowf2n	16	16	into	into	IN
cord-288670-1vlowf2n	16	17	3	3	CD
cord-288670-1vlowf2n	16	18	groups	group	NNS
cord-288670-1vlowf2n	16	19	:	:	:
cord-288670-1vlowf2n	16	20	α	α	NN
cord-288670-1vlowf2n	16	21	-	-	HYPH
cord-288670-1vlowf2n	16	22	CoVs	CoVs	NNP
cord-288670-1vlowf2n	16	23	,	,	,
cord-288670-1vlowf2n	16	24	β	β	NN
cord-288670-1vlowf2n	16	25	-	-	HYPH
cord-288670-1vlowf2n	16	26	CoVs	CoVs	NNP
cord-288670-1vlowf2n	16	27	,	,	,
cord-288670-1vlowf2n	16	28	and	and	CC
cord-288670-1vlowf2n	16	29	γ	γ	NN
cord-288670-1vlowf2n	16	30	-	-	HYPH
cord-288670-1vlowf2n	16	31	CoVs	CoVs	NNP
cord-288670-1vlowf2n	16	32	[	[	-LRB-
cord-288670-1vlowf2n	16	33	2	2	CD
cord-288670-1vlowf2n	16	34	]	]	-RRB-
cord-288670-1vlowf2n	16	35	.	.	.
cord-288670-1vlowf2n	17	1	Two	two	CD
cord-288670-1vlowf2n	17	2	of	of	IN
cord-288670-1vlowf2n	17	3	the	the	DT
cord-288670-1vlowf2n	17	4	β	β	NN
cord-288670-1vlowf2n	17	5	-	-	HYPH
cord-288670-1vlowf2n	17	6	CoVs	CoVs	NNP
cord-288670-1vlowf2n	17	7	including	include	VBG
cord-288670-1vlowf2n	17	8	severe	severe	JJ
cord-288670-1vlowf2n	17	9	acute	acute	JJ
cord-288670-1vlowf2n	17	10	respiratory	respiratory	JJ
cord-288670-1vlowf2n	17	11	syndrome	syndrome	NN
cord-288670-1vlowf2n	17	12	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	17	13	(	(	-LRB-
cord-288670-1vlowf2n	17	14	SARS	SARS	NNP
cord-288670-1vlowf2n	17	15	-	-	HYPH
cord-288670-1vlowf2n	17	16	CoV	CoV	NNP
cord-288670-1vlowf2n	17	17	)	)	-RRB-
cord-288670-1vlowf2n	17	18	and	and	CC
cord-288670-1vlowf2n	17	19	Middle	Middle	NNP
cord-288670-1vlowf2n	17	20	East	East	NNP
cord-288670-1vlowf2n	17	21	respiratory	respiratory	JJ
cord-288670-1vlowf2n	17	22	syndrome	syndrome	NN
cord-288670-1vlowf2n	17	23	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	17	24	(	(	-LRB-
cord-288670-1vlowf2n	17	25	MERS	MERS	NNP
cord-288670-1vlowf2n	17	26	-	-	HYPH
cord-288670-1vlowf2n	17	27	CoV	CoV	NNP
cord-288670-1vlowf2n	17	28	)	)	-RRB-
cord-288670-1vlowf2n	17	29	caused	cause	VBD
cord-288670-1vlowf2n	17	30	severe	severe	JJ
cord-288670-1vlowf2n	17	31	acute	acute	JJ
cord-288670-1vlowf2n	17	32	respiratory	respiratory	JJ
cord-288670-1vlowf2n	17	33	disease	disease	NN
cord-288670-1vlowf2n	17	34	outbreaks	outbreak	NNS
cord-288670-1vlowf2n	17	35	in	in	IN
cord-288670-1vlowf2n	17	36	China	China	NNP
cord-288670-1vlowf2n	17	37	in	in	IN
cord-288670-1vlowf2n	17	38	[	[	-LRB-
cord-288670-1vlowf2n	17	39	2002	2002	CD
cord-288670-1vlowf2n	17	40	]	]	-RRB-
cord-288670-1vlowf2n	18	1	[	[	-LRB-
cord-288670-1vlowf2n	18	2	2003	2003	CD
cord-288670-1vlowf2n	18	3	]	]	-RRB-
cord-288670-1vlowf2n	18	4	and	and	CC
cord-288670-1vlowf2n	18	5	in	in	IN
cord-288670-1vlowf2n	18	6	the	the	DT
cord-288670-1vlowf2n	18	7	Middle	Middle	NNP
cord-288670-1vlowf2n	18	8	East	East	NNP
cord-288670-1vlowf2n	18	9	in	in	IN
cord-288670-1vlowf2n	18	10	2012	2012	CD
cord-288670-1vlowf2n	18	11	,	,	,
cord-288670-1vlowf2n	18	12	respectively	respectively	RB
cord-288670-1vlowf2n	18	13	[	[	-LRB-
cord-288670-1vlowf2n	18	14	3	3	CD
cord-288670-1vlowf2n	18	15	]	]	-RRB-
cord-288670-1vlowf2n	18	16	.	.	.
cord-288670-1vlowf2n	19	1	In	in	IN
cord-288670-1vlowf2n	19	2	December	December	NNP
cord-288670-1vlowf2n	19	3	2019	2019	CD
cord-288670-1vlowf2n	19	4	,	,	,
cord-288670-1vlowf2n	19	5	a	a	DT
cord-288670-1vlowf2n	19	6	novel	novel	JJ
cord-288670-1vlowf2n	19	7	CoV	cov	NN
cord-288670-1vlowf2n	19	8	outbreak	outbreak	NN
cord-288670-1vlowf2n	19	9	,	,	,
cord-288670-1vlowf2n	19	10	identified	identify	VBN
cord-288670-1vlowf2n	19	11	and	and	CC
cord-288670-1vlowf2n	19	12	named	name	VBN
cord-288670-1vlowf2n	19	13	as	as	IN
cord-288670-1vlowf2n	19	14	severe	severe	JJ
cord-288670-1vlowf2n	19	15	acute	acute	JJ
cord-288670-1vlowf2n	19	16	respiratory	respiratory	JJ
cord-288670-1vlowf2n	19	17	syndrome	syndrome	NN
cord-288670-1vlowf2n	19	18	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	19	19	2	2	CD
cord-288670-1vlowf2n	19	20	(	(	-LRB-
cord-288670-1vlowf2n	19	21	SARS	SARS	NNP
cord-288670-1vlowf2n	19	22	-	-	HYPH
cord-288670-1vlowf2n	19	23	Cov-2	Cov-2	NNP
cord-288670-1vlowf2n	19	24	)	)	-RRB-
cord-288670-1vlowf2n	19	25	started	start	VBD
cord-288670-1vlowf2n	19	26	in	in	IN
cord-288670-1vlowf2n	19	27	Wuhan	Wuhan	NNP
cord-288670-1vlowf2n	19	28	,	,	,
cord-288670-1vlowf2n	19	29	Hubei	Hubei	NNP
cord-288670-1vlowf2n	19	30	province	province	NN
cord-288670-1vlowf2n	19	31	,	,	,
cord-288670-1vlowf2n	19	32	China	China	NNP
cord-288670-1vlowf2n	19	33	.	.	.
cord-288670-1vlowf2n	20	1	The	the	DT
cord-288670-1vlowf2n	20	2	SARS	SARS	NNP
cord-288670-1vlowf2n	20	3	-	-	HYPH
cord-288670-1vlowf2n	20	4	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	20	5	spread	spread	VBD
cord-288670-1vlowf2n	20	6	very	very	RB
cord-288670-1vlowf2n	20	7	quickly	quickly	RB
cord-288670-1vlowf2n	20	8	in	in	IN
cord-288670-1vlowf2n	20	9	China	China	NNP
cord-288670-1vlowf2n	20	10	and	and	CC
cord-288670-1vlowf2n	20	11	then	then	RB
cord-288670-1vlowf2n	20	12	to	to	IN
cord-288670-1vlowf2n	20	13	the	the	DT
cord-288670-1vlowf2n	20	14	many	many	JJ
cord-288670-1vlowf2n	20	15	other	other	JJ
cord-288670-1vlowf2n	20	16	countries	country	NNS
cord-288670-1vlowf2n	20	17	,	,	,
cord-288670-1vlowf2n	20	18	causing	cause	VBG
cord-288670-1vlowf2n	20	19	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	20	20	disease-19	disease-19	CD
cord-288670-1vlowf2n	20	21	.	.	.
cord-288670-1vlowf2n	21	1	The	the	DT
cord-288670-1vlowf2n	21	2	clinical	clinical	JJ
cord-288670-1vlowf2n	21	3	futures	future	NNS
cord-288670-1vlowf2n	21	4	of	of	IN
cord-288670-1vlowf2n	21	5	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	21	6	mainly	mainly	RB
cord-288670-1vlowf2n	21	7	include	include	VBP
cord-288670-1vlowf2n	21	8	fever	fever	NN
cord-288670-1vlowf2n	21	9	,	,	,
cord-288670-1vlowf2n	21	10	cough	cough	NN
cord-288670-1vlowf2n	21	11	and	and	CC
cord-288670-1vlowf2n	21	12	pneumonia	pneumonia	NN
cord-288670-1vlowf2n	21	13	[	[	-LRB-
cord-288670-1vlowf2n	21	14	4	4	CD
cord-288670-1vlowf2n	21	15	]	]	-RRB-
cord-288670-1vlowf2n	21	16	.	.	.
cord-288670-1vlowf2n	22	1	Up	up	IN
cord-288670-1vlowf2n	22	2	to	to	IN
cord-288670-1vlowf2n	22	3	date	date	NN
cord-288670-1vlowf2n	22	4	,	,	,
cord-288670-1vlowf2n	22	5	it	-PRON-	PRP
cord-288670-1vlowf2n	22	6	has	have	VBZ
cord-288670-1vlowf2n	22	7	already	already	RB
cord-288670-1vlowf2n	22	8	infected	infect	VBN
cord-288670-1vlowf2n	22	9	more	more	JJR
cord-288670-1vlowf2n	22	10	than	than	IN
cord-288670-1vlowf2n	22	11	90,000	90,000	CD
cord-288670-1vlowf2n	22	12	people	people	NNS
cord-288670-1vlowf2n	22	13	worldwide	worldwide	RB
cord-288670-1vlowf2n	22	14	and	and	CC
cord-288670-1vlowf2n	22	15	killed	kill	VBD
cord-288670-1vlowf2n	22	16	more	more	JJR
cord-288670-1vlowf2n	22	17	than	than	IN
cord-288670-1vlowf2n	22	18	three	three	CD
cord-288670-1vlowf2n	22	19	thousand	thousand	CD
cord-288670-1vlowf2n	22	20	patients	patient	NNS
cord-288670-1vlowf2n	22	21	,	,	,
cord-288670-1vlowf2n	22	22	mainly	mainly	RB
cord-288670-1vlowf2n	22	23	in	in	IN
cord-288670-1vlowf2n	22	24	Wuhan	Wuhan	NNP
cord-288670-1vlowf2n	22	25	,	,	,
cord-288670-1vlowf2n	22	26	China	China	NNP
cord-288670-1vlowf2n	22	27	.	.	.
cord-288670-1vlowf2n	23	1	SARS	SARS	NNP
cord-288670-1vlowf2n	23	2	-	-	HYPH
cord-288670-1vlowf2n	23	3	Cov-2	Cov-2	NNP
cord-288670-1vlowf2n	23	4	shares	share	VBZ
cord-288670-1vlowf2n	23	5	a	a	DT
cord-288670-1vlowf2n	23	6	high	high	JJ
cord-288670-1vlowf2n	23	7	sequence	sequence	NN
cord-288670-1vlowf2n	23	8	identity	identity	NN
cord-288670-1vlowf2n	23	9	(	(	-LRB-
cord-288670-1vlowf2n	23	10	around	around	IN
cord-288670-1vlowf2n	23	11	80	80	CD
cord-288670-1vlowf2n	23	12	%	%	NN
cord-288670-1vlowf2n	23	13	)	)	-RRB-
cord-288670-1vlowf2n	23	14	with	with	IN
cord-288670-1vlowf2n	23	15	SARS	SARS	NNP
cord-288670-1vlowf2n	23	16	-	-	HYPH
cord-288670-1vlowf2n	23	17	CoV	CoV	NNP
cord-288670-1vlowf2n	23	18	and	and	CC
cord-288670-1vlowf2n	23	19	a	a	DT
cord-288670-1vlowf2n	23	20	96.2	96.2	CD
cord-288670-1vlowf2n	23	21	%	%	NN
cord-288670-1vlowf2n	23	22	sequence	sequence	NN
cord-288670-1vlowf2n	23	23	identity	identity	NN
cord-288670-1vlowf2n	23	24	with	with	IN
cord-288670-1vlowf2n	23	25	BatCoV	BatCoV	NNP
cord-288670-1vlowf2n	23	26	RaTG13	RaTG13	NNP
cord-288670-1vlowf2n	23	27	,	,	,
cord-288670-1vlowf2n	23	28	a	a	DT
cord-288670-1vlowf2n	23	29	bat	bat	NN
cord-288670-1vlowf2n	23	30	CoV	cov	NN
cord-288670-1vlowf2n	23	31	[	[	-LRB-
cord-288670-1vlowf2n	23	32	5	5	CD
cord-288670-1vlowf2n	23	33	]	]	-RRB-
cord-288670-1vlowf2n	23	34	.	.	.
cord-288670-1vlowf2n	24	1	Although	although	IN
cord-288670-1vlowf2n	24	2	some	some	DT
cord-288670-1vlowf2n	24	3	initial	initial	JJ
cord-288670-1vlowf2n	24	4	cases	case	NNS
cord-288670-1vlowf2n	24	5	were	be	VBD
cord-288670-1vlowf2n	24	6	linked	link	VBN
cord-288670-1vlowf2n	24	7	to	to	IN
cord-288670-1vlowf2n	24	8	a	a	DT
cord-288670-1vlowf2n	24	9	local	local	JJ
cord-288670-1vlowf2n	24	10	seafood	seafood	NN
cord-288670-1vlowf2n	24	11	market	market	NN
cord-288670-1vlowf2n	24	12	in	in	IN
cord-288670-1vlowf2n	24	13	Wuhan	Wuhan	NNP
cord-288670-1vlowf2n	24	14	,	,	,
cord-288670-1vlowf2n	24	15	its	-PRON-	PRP$
cord-288670-1vlowf2n	24	16	origin	origin	NN
cord-288670-1vlowf2n	24	17	,	,	,
cord-288670-1vlowf2n	24	18	intermediate	intermediate	JJ
cord-288670-1vlowf2n	24	19	hosts	host	NNS
cord-288670-1vlowf2n	24	20	and	and	CC
cord-288670-1vlowf2n	24	21	how	how	WRB
cord-288670-1vlowf2n	24	22	it	-PRON-	PRP
cord-288670-1vlowf2n	24	23	was	be	VBD
cord-288670-1vlowf2n	24	24	transmitted	transmit	VBN
cord-288670-1vlowf2n	24	25	to	to	IN
cord-288670-1vlowf2n	24	26	humans	human	NNS
cord-288670-1vlowf2n	24	27	are	be	VBP
cord-288670-1vlowf2n	24	28	still	still	RB
cord-288670-1vlowf2n	24	29	largely	largely	RB
cord-288670-1vlowf2n	24	30	unknown	unknown	JJ
cord-288670-1vlowf2n	24	31	[	[	-LRB-
cord-288670-1vlowf2n	24	32	4	4	CD
cord-288670-1vlowf2n	24	33	]	]	-RRB-
cord-288670-1vlowf2n	24	34	.	.	.
cord-288670-1vlowf2n	25	1	In	in	IN
cord-288670-1vlowf2n	25	2	this	this	DT
cord-288670-1vlowf2n	25	3	mini	mini	JJ
cord-288670-1vlowf2n	25	4	-	-	NN
cord-288670-1vlowf2n	25	5	review	review	NN
cord-288670-1vlowf2n	25	6	,	,	,
cord-288670-1vlowf2n	25	7	we	-PRON-	PRP
cord-288670-1vlowf2n	25	8	will	will	MD
cord-288670-1vlowf2n	25	9	mainly	mainly	RB
cord-288670-1vlowf2n	25	10	focus	focus	VB
cord-288670-1vlowf2n	25	11	on	on	IN
cord-288670-1vlowf2n	25	12	β	β	NNP
cord-288670-1vlowf2n	25	13	-	-	HYPH
cord-288670-1vlowf2n	25	14	CoV	CoV	NNP
cord-288670-1vlowf2n	25	15	,	,	,
cord-288670-1vlowf2n	25	16	which	which	WDT
cord-288670-1vlowf2n	25	17	is	be	VBZ
cord-288670-1vlowf2n	25	18	inclusive	inclusive	JJ
cord-288670-1vlowf2n	25	19	of	of	IN
cord-288670-1vlowf2n	25	20	SARS	SARS	NNP
cord-288670-1vlowf2n	25	21	-	-	HYPH
cord-288670-1vlowf2n	25	22	CoV	CoV	NNP
cord-288670-1vlowf2n	25	23	,	,	,
cord-288670-1vlowf2n	25	24	MERS	MERS	NNP
cord-288670-1vlowf2n	25	25	-	-	HYPH
cord-288670-1vlowf2n	25	26	CoV	CoV	NNP
cord-288670-1vlowf2n	25	27	,	,	,
cord-288670-1vlowf2n	25	28	and	and	CC
cord-288670-1vlowf2n	25	29	the	the	DT
cord-288670-1vlowf2n	25	30	current	current	JJ
cord-288670-1vlowf2n	25	31	emerging	emerge	VBG
cord-288670-1vlowf2n	25	32	SARS	SARS	NNP
cord-288670-1vlowf2n	25	33	-	-	HYPH
cord-288670-1vlowf2n	25	34	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	25	35	to	to	TO
cord-288670-1vlowf2n	25	36	discuss	discuss	VB
cord-288670-1vlowf2n	25	37	the	the	DT
cord-288670-1vlowf2n	25	38	implication	implication	NN
cord-288670-1vlowf2n	25	39	of	of	IN
cord-288670-1vlowf2n	25	40	the	the	DT
cord-288670-1vlowf2n	25	41	endocytic	endocytic	JJ
cord-288670-1vlowf2n	25	42	pathway	pathway	NN
cord-288670-1vlowf2n	25	43	and	and	CC
cord-288670-1vlowf2n	25	44	autophagy	autophagy	NN
cord-288670-1vlowf2n	25	45	process	process	NN
cord-288670-1vlowf2n	25	46	in	in	IN
cord-288670-1vlowf2n	25	47	the	the	DT
cord-288670-1vlowf2n	25	48	infection	infection	NN
cord-288670-1vlowf2n	25	49	of	of	IN
cord-288670-1vlowf2n	25	50	these	these	DT
cord-288670-1vlowf2n	25	51	pathogenic	pathogenic	JJ
cord-288670-1vlowf2n	25	52	CoVs	covs	NN
cord-288670-1vlowf2n	25	53	and	and	CC
cord-288670-1vlowf2n	25	54	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	25	55	potential	potential	NN
cord-288670-1vlowf2n	25	56	of	of	IN
cord-288670-1vlowf2n	25	57	targeting	target	VBG
cord-288670-1vlowf2n	25	58	these	these	DT
cord-288670-1vlowf2n	25	59	processes	process	NNS
cord-288670-1vlowf2n	25	60	.	.	.
cord-288670-1vlowf2n	26	1	This	this	DT
cord-288670-1vlowf2n	26	2	review	review	NN
cord-288670-1vlowf2n	26	3	will	will	MD
cord-288670-1vlowf2n	26	4	also	also	RB
cord-288670-1vlowf2n	26	5	include	include	VB
cord-288670-1vlowf2n	26	6	the	the	DT
cord-288670-1vlowf2n	26	7	well	well	RB
cord-288670-1vlowf2n	26	8	-	-	HYPH
cord-288670-1vlowf2n	26	9	studied	study	VBN
cord-288670-1vlowf2n	26	10	mouse	mouse	NN
cord-288670-1vlowf2n	26	11	hepatitis	hepatitis	NN
cord-288670-1vlowf2n	26	12	virus	virus	NN
cord-288670-1vlowf2n	26	13	(	(	-LRB-
cord-288670-1vlowf2n	26	14	MHV	MHV	NNP
cord-288670-1vlowf2n	26	15	)	)	-RRB-
cord-288670-1vlowf2n	26	16	since	since	IN
cord-288670-1vlowf2n	26	17	it	-PRON-	PRP
cord-288670-1vlowf2n	26	18	is	be	VBZ
cord-288670-1vlowf2n	26	19	often	often	RB
cord-288670-1vlowf2n	26	20	used	use	VBN
cord-288670-1vlowf2n	26	21	as	as	IN
cord-288670-1vlowf2n	26	22	a	a	DT
cord-288670-1vlowf2n	26	23	safe	safe	JJ
cord-288670-1vlowf2n	26	24	mode	mode	NN
cord-288670-1vlowf2n	26	25	to	to	TO
cord-288670-1vlowf2n	26	26	study	study	VB
cord-288670-1vlowf2n	26	27	CoV	cov	NN
cord-288670-1vlowf2n	26	28	infection	infection	NN
cord-288670-1vlowf2n	26	29	.	.	.
cord-288670-1vlowf2n	27	1	Macroautophagy	Macroautophagy	NNS
cord-288670-1vlowf2n	27	2	or	or	CC
cord-288670-1vlowf2n	27	3	autophagy	autophagy	NN
cord-288670-1vlowf2n	27	4	refers	refer	VBZ
cord-288670-1vlowf2n	27	5	to	to	IN
cord-288670-1vlowf2n	27	6	an	an	DT
cord-288670-1vlowf2n	27	7	evolutionarily	evolutionarily	RB
cord-288670-1vlowf2n	27	8	conserved	conserved	JJ
cord-288670-1vlowf2n	27	9	process	process	NN
cord-288670-1vlowf2n	27	10	in	in	IN
cord-288670-1vlowf2n	27	11	which	which	WDT
cord-288670-1vlowf2n	27	12	the	the	DT
cord-288670-1vlowf2n	27	13	intracellular	intracellular	JJ
cord-288670-1vlowf2n	27	14	components	component	NNS
cord-288670-1vlowf2n	27	15	such	such	JJ
cord-288670-1vlowf2n	27	16	as	as	IN
cord-288670-1vlowf2n	27	17	protein	protein	NN
cord-288670-1vlowf2n	27	18	aggregates	aggregate	NNS
cord-288670-1vlowf2n	27	19	and	and	CC
cord-288670-1vlowf2n	27	20	damaged	damage	VBN
cord-288670-1vlowf2n	27	21	organelles	organelle	NNS
cord-288670-1vlowf2n	27	22	are	be	VBP
cord-288670-1vlowf2n	27	23	engulfed	engulf	VBN
cord-288670-1vlowf2n	27	24	into	into	IN
cord-288670-1vlowf2n	27	25	a	a	DT
cord-288670-1vlowf2n	27	26	double	double	JJ
cord-288670-1vlowf2n	27	27	-	-	HYPH
cord-288670-1vlowf2n	27	28	membrane	membrane	NN
cord-288670-1vlowf2n	27	29	structure	structure	NN
cord-288670-1vlowf2n	27	30	called	call	VBN
cord-288670-1vlowf2n	27	31	autophagosome	autophagosome	NNP
cord-288670-1vlowf2n	27	32	,	,	,
cord-288670-1vlowf2n	27	33	which	which	WDT
cord-288670-1vlowf2n	27	34	eventually	eventually	RB
cord-288670-1vlowf2n	27	35	fuses	fuse	VBZ
cord-288670-1vlowf2n	27	36	with	with	IN
cord-288670-1vlowf2n	27	37	lysosome	lysosome	NN
cord-288670-1vlowf2n	27	38	to	to	TO
cord-288670-1vlowf2n	27	39	form	form	VB
cord-288670-1vlowf2n	27	40	autolysosome	autolysosome	NN
cord-288670-1vlowf2n	27	41	for	for	IN
cord-288670-1vlowf2n	27	42	degradation	degradation	NN
cord-288670-1vlowf2n	27	43	[	[	-LRB-
cord-288670-1vlowf2n	27	44	6	6	CD
cord-288670-1vlowf2n	27	45	,	,	,
cord-288670-1vlowf2n	27	46	7	7	CD
cord-288670-1vlowf2n	27	47	]	]	-RRB-
cord-288670-1vlowf2n	28	1	(	(	-LRB-
cord-288670-1vlowf2n	28	2	Figure	figure	NN
cord-288670-1vlowf2n	28	3	1	1	CD
cord-288670-1vlowf2n	28	4	)	)	-RRB-
cord-288670-1vlowf2n	28	5	.	.	.
cord-288670-1vlowf2n	29	1	The	the	DT
cord-288670-1vlowf2n	29	2	whole	whole	JJ
cord-288670-1vlowf2n	29	3	autophagy	autophagy	NN
cord-288670-1vlowf2n	29	4	process	process	NN
cord-288670-1vlowf2n	29	5	is	be	VBZ
cord-288670-1vlowf2n	29	6	controlled	control	VBN
cord-288670-1vlowf2n	29	7	by	by	IN
cord-288670-1vlowf2n	29	8	a	a	DT
cord-288670-1vlowf2n	29	9	group	group	NN
cord-288670-1vlowf2n	29	10	of	of	IN
cord-288670-1vlowf2n	29	11	proteins	protein	NNS
cord-288670-1vlowf2n	29	12	encoded	encode	VBN
cord-288670-1vlowf2n	29	13	by	by	IN
cord-288670-1vlowf2n	29	14	autophagy	autophagy	NN
cord-288670-1vlowf2n	29	15	-	-	HYPH
cord-288670-1vlowf2n	29	16	related	relate	VBN
cord-288670-1vlowf2n	29	17	-	-	HYPH
cord-288670-1vlowf2n	29	18	genes	gene	NNS
cord-288670-1vlowf2n	29	19	(	(	-LRB-
cord-288670-1vlowf2n	29	20	ATGs	atg	NNS
cord-288670-1vlowf2n	29	21	)	)	-RRB-
cord-288670-1vlowf2n	29	22	in	in	IN
cord-288670-1vlowf2n	29	23	several	several	JJ
cord-288670-1vlowf2n	29	24	consecutive	consecutive	JJ
cord-288670-1vlowf2n	29	25	stages	stage	NNS
cord-288670-1vlowf2n	29	26	[	[	-LRB-
cord-288670-1vlowf2n	29	27	8	8	CD
cord-288670-1vlowf2n	29	28	,	,	,
cord-288670-1vlowf2n	29	29	9	9	CD
cord-288670-1vlowf2n	29	30	]	]	-RRB-
cord-288670-1vlowf2n	29	31	.	.	.
cord-288670-1vlowf2n	30	1	First	first	RB
cord-288670-1vlowf2n	30	2	,	,	,
cord-288670-1vlowf2n	30	3	the	the	DT
cord-288670-1vlowf2n	30	4	induction	induction	NN
cord-288670-1vlowf2n	30	5	or	or	CC
cord-288670-1vlowf2n	30	6	initiation	initiation	NN
cord-288670-1vlowf2n	30	7	stage	stage	NN
cord-288670-1vlowf2n	30	8	is	be	VBZ
cord-288670-1vlowf2n	30	9	controlled	control	VBN
cord-288670-1vlowf2n	30	10	by	by	IN
cord-288670-1vlowf2n	30	11	the	the	DT
cord-288670-1vlowf2n	30	12	ULK1	ULK1	NNP
cord-288670-1vlowf2n	30	13	/	/	SYM
cord-288670-1vlowf2n	30	14	Atg1	Atg1	NNP
cord-288670-1vlowf2n	30	15	complex	complex	NN
cord-288670-1vlowf2n	30	16	,	,	,
cord-288670-1vlowf2n	30	17	downstream	downstream	RB
cord-288670-1vlowf2n	30	18	of	of	IN
cord-288670-1vlowf2n	30	19	the	the	DT
cord-288670-1vlowf2n	30	20	mechanistic	mechanistic	JJ
cord-288670-1vlowf2n	30	21	target	target	NN
cord-288670-1vlowf2n	30	22	of	of	IN
cord-288670-1vlowf2n	30	23	rapamycin	rapamycin	NN
cord-288670-1vlowf2n	30	24	complex	complex	NNP
cord-288670-1vlowf2n	30	25	1	1	CD
cord-288670-1vlowf2n	30	26	(	(	-LRB-
cord-288670-1vlowf2n	30	27	mTORC1	mtorc1	NN
cord-288670-1vlowf2n	30	28	)	)	-RRB-
cord-288670-1vlowf2n	30	29	.	.	.
cord-288670-1vlowf2n	31	1	Second	second	RB
cord-288670-1vlowf2n	31	2	,	,	,
cord-288670-1vlowf2n	31	3	the	the	DT
cord-288670-1vlowf2n	31	4	nucleation	nucleation	NN
cord-288670-1vlowf2n	31	5	/	/	SYM
cord-288670-1vlowf2n	31	6	expansion	expansion	NN
cord-288670-1vlowf2n	31	7	/	/	SYM
cord-288670-1vlowf2n	31	8	elongation	elongation	NN
cord-288670-1vlowf2n	31	9	stage	stage	NN
cord-288670-1vlowf2n	31	10	is	be	VBZ
cord-288670-1vlowf2n	31	11	mediated	mediate	VBN
cord-288670-1vlowf2n	31	12	by	by	IN
cord-288670-1vlowf2n	31	13	the	the	DT
cord-288670-1vlowf2n	31	14	ATG14-Beclin1-hVPS34	ATG14-Beclin1-hVPS34	NNS
cord-288670-1vlowf2n	31	15	/	/	SYM
cord-288670-1vlowf2n	31	16	class	class	NN
cord-288670-1vlowf2n	31	17	III	iii	CD
cord-288670-1vlowf2n	31	18	phosphatidylinositol	phosphatidylinositol	JJ
cord-288670-1vlowf2n	31	19	3-kinases	3-kinases	CD
cord-288670-1vlowf2n	32	1	(	(	-LRB-
cord-288670-1vlowf2n	32	2	PI3	PI3	NNP
cord-288670-1vlowf2n	32	3	K	K	NNP
cord-288670-1vlowf2n	32	4	)	)	-RRB-
cord-288670-1vlowf2n	32	5	complex	complex	NN
cord-288670-1vlowf2n	32	6	,	,	,
cord-288670-1vlowf2n	32	7	as	as	RB
cord-288670-1vlowf2n	32	8	well	well	RB
cord-288670-1vlowf2n	32	9	as	as	IN
cord-288670-1vlowf2n	32	10	the	the	DT
cord-288670-1vlowf2n	32	11	two	two	CD
cord-288670-1vlowf2n	32	12	ubiquitin	ubiquitin	NN
cord-288670-1vlowf2n	32	13	-	-	HYPH
cord-288670-1vlowf2n	32	14	like	like	JJ
cord-288670-1vlowf2n	32	15	conjugation	conjugation	NN
cord-288670-1vlowf2n	32	16	systems	system	NNS
cord-288670-1vlowf2n	32	17	(	(	-LRB-
cord-288670-1vlowf2n	32	18	ATG5-ATG12	ATG5-ATG12	NNP
cord-288670-1vlowf2n	32	19	and	and	CC
cord-288670-1vlowf2n	32	20	LC3	LC3	NNP
cord-288670-1vlowf2n	32	21	/	/	SYM
cord-288670-1vlowf2n	32	22	ATG8	ATG8	NNP
cord-288670-1vlowf2n	32	23	)	)	-RRB-
cord-288670-1vlowf2n	32	24	.	.	.
cord-288670-1vlowf2n	33	1	The	the	DT
cord-288670-1vlowf2n	33	2	third	third	JJ
cord-288670-1vlowf2n	33	3	and	and	CC
cord-288670-1vlowf2n	33	4	last	last	JJ
cord-288670-1vlowf2n	33	5	stage	stage	NN
cord-288670-1vlowf2n	33	6	of	of	IN
cord-288670-1vlowf2n	33	7	autophagy	autophagy	NN
cord-288670-1vlowf2n	33	8	is	be	VBZ
cord-288670-1vlowf2n	33	9	the	the	DT
cord-288670-1vlowf2n	33	10	maturation	maturation	NN
cord-288670-1vlowf2n	33	11	/	/	SYM
cord-288670-1vlowf2n	33	12	fusion	fusion	NN
cord-288670-1vlowf2n	33	13	/	/	SYM
cord-288670-1vlowf2n	33	14	degradation	degradation	NN
cord-288670-1vlowf2n	33	15	in	in	IN
cord-288670-1vlowf2n	33	16	which	which	WDT
cord-288670-1vlowf2n	33	17	autophagosome	autophagosome	NNP
cord-288670-1vlowf2n	33	18	fuses	fuse	NNS
cord-288670-1vlowf2n	33	19	with	with	IN
cord-288670-1vlowf2n	33	20	lysosome	lysosome	NN
cord-288670-1vlowf2n	33	21	to	to	TO
cord-288670-1vlowf2n	33	22	form	form	VB
cord-288670-1vlowf2n	33	23	autolysosome	autolysosome	NNP
cord-288670-1vlowf2n	33	24	where	where	WRB
cord-288670-1vlowf2n	33	25	the	the	DT
cord-288670-1vlowf2n	33	26	luminal	luminal	JJ
cord-288670-1vlowf2n	33	27	contents	content	NNS
cord-288670-1vlowf2n	33	28	are	be	VBP
cord-288670-1vlowf2n	33	29	degraded	degrade	VBN
cord-288670-1vlowf2n	33	30	(	(	-LRB-
cord-288670-1vlowf2n	33	31	Figure	figure	NN
cord-288670-1vlowf2n	33	32	1	1	CD
cord-288670-1vlowf2n	33	33	)	)	-RRB-
cord-288670-1vlowf2n	33	34	.	.	.
cord-288670-1vlowf2n	34	1	At	at	IN
cord-288670-1vlowf2n	34	2	present	present	NN
cord-288670-1vlowf2n	34	3	,	,	,
cord-288670-1vlowf2n	34	4	the	the	DT
cord-288670-1vlowf2n	34	5	biological	biological	JJ
cord-288670-1vlowf2n	34	6	functions	function	NNS
cord-288670-1vlowf2n	34	7	of	of	IN
cord-288670-1vlowf2n	34	8	autophagy	autophagy	NN
cord-288670-1vlowf2n	34	9	have	have	VBP
cord-288670-1vlowf2n	34	10	been	be	VBN
cord-288670-1vlowf2n	34	11	extensively	extensively	RB
cord-288670-1vlowf2n	34	12	studied	study	VBN
cord-288670-1vlowf2n	34	13	.	.	.
cord-288670-1vlowf2n	35	1	Autophagy	Autophagy	NNP
cord-288670-1vlowf2n	35	2	plays	play	VBZ
cord-288670-1vlowf2n	35	3	an	an	DT
cord-288670-1vlowf2n	35	4	important	important	JJ
cord-288670-1vlowf2n	35	5	role	role	NN
cord-288670-1vlowf2n	35	6	in	in	IN
cord-288670-1vlowf2n	35	7	various	various	JJ
cord-288670-1vlowf2n	35	8	physiological	physiological	JJ
cord-288670-1vlowf2n	35	9	and	and	CC
cord-288670-1vlowf2n	35	10	pathological	pathological	JJ
cord-288670-1vlowf2n	35	11	processes	process	NNS
cord-288670-1vlowf2n	35	12	,	,	,
cord-288670-1vlowf2n	35	13	including	include	VBG
cord-288670-1vlowf2n	35	14	cell	cell	NN
cord-288670-1vlowf2n	35	15	survival	survival	NN
cord-288670-1vlowf2n	35	16	,	,	,
cord-288670-1vlowf2n	35	17	cell	cell	NN
cord-288670-1vlowf2n	35	18	death	death	NN
cord-288670-1vlowf2n	35	19	,	,	,
cord-288670-1vlowf2n	35	20	aging	aging	NN
cord-288670-1vlowf2n	35	21	,	,	,
cord-288670-1vlowf2n	35	22	immunity	immunity	NN
cord-288670-1vlowf2n	35	23	and	and	CC
cord-288670-1vlowf2n	35	24	metabolism	metabolism	NN
cord-288670-1vlowf2n	35	25	[	[	-LRB-
cord-288670-1vlowf2n	35	26	10	10	CD
cord-288670-1vlowf2n	35	27	,	,	,
cord-288670-1vlowf2n	35	28	11	11	CD
cord-288670-1vlowf2n	35	29	]	]	-RRB-
cord-288670-1vlowf2n	35	30	.	.	.
cord-288670-1vlowf2n	36	1	More	more	RBR
cord-288670-1vlowf2n	36	2	importantly	importantly	RB
cord-288670-1vlowf2n	36	3	,	,	,
cord-288670-1vlowf2n	36	4	accumulating	accumulate	VBG
cord-288670-1vlowf2n	36	5	evidence	evidence	NN
cord-288670-1vlowf2n	36	6	has	have	VBZ
cord-288670-1vlowf2n	36	7	highlighted	highlight	VBN
cord-288670-1vlowf2n	36	8	the	the	DT
cord-288670-1vlowf2n	36	9	importance	importance	NN
cord-288670-1vlowf2n	36	10	of	of	IN
cord-288670-1vlowf2n	36	11	autophagy	autophagy	NN
cord-288670-1vlowf2n	36	12	in	in	IN
cord-288670-1vlowf2n	36	13	many	many	JJ
cord-288670-1vlowf2n	36	14	human	human	JJ
cord-288670-1vlowf2n	36	15	diseases	disease	NNS
cord-288670-1vlowf2n	36	16	,	,	,
cord-288670-1vlowf2n	36	17	such	such	JJ
cord-288670-1vlowf2n	36	18	as	as	IN
cord-288670-1vlowf2n	36	19	cancer	cancer	NN
cord-288670-1vlowf2n	36	20	,	,	,
cord-288670-1vlowf2n	36	21	neurodegenerative	neurodegenerative	JJ
cord-288670-1vlowf2n	36	22	diseases	disease	NNS
cord-288670-1vlowf2n	36	23	,	,	,
cord-288670-1vlowf2n	36	24	metabolic	metabolic	JJ
cord-288670-1vlowf2n	36	25	disorders	disorder	NNS
cord-288670-1vlowf2n	36	26	,	,	,
cord-288670-1vlowf2n	36	27	as	as	RB
cord-288670-1vlowf2n	36	28	well	well	RB
cord-288670-1vlowf2n	36	29	as	as	IN
cord-288670-1vlowf2n	36	30	immunity	immunity	NN
cord-288670-1vlowf2n	36	31	and	and	CC
cord-288670-1vlowf2n	36	32	infection	infection	NN
cord-288670-1vlowf2n	36	33	[	[	-LRB-
cord-288670-1vlowf2n	36	34	12	12	CD
cord-288670-1vlowf2n	36	35	,	,	,
cord-288670-1vlowf2n	36	36	13	13	CD
cord-288670-1vlowf2n	36	37	]	]	-RRB-
cord-288670-1vlowf2n	36	38	.	.	.
cord-288670-1vlowf2n	37	1	Among	among	IN
cord-288670-1vlowf2n	37	2	them	-PRON-	PRP
cord-288670-1vlowf2n	37	3	,	,	,
cord-288670-1vlowf2n	37	4	the	the	DT
cord-288670-1vlowf2n	37	5	implication	implication	NN
cord-288670-1vlowf2n	37	6	of	of	IN
cord-288670-1vlowf2n	37	7	autophagy	autophagy	NN
cord-288670-1vlowf2n	37	8	in	in	IN
cord-288670-1vlowf2n	37	9	viral	viral	JJ
cord-288670-1vlowf2n	37	10	infection	infection	NN
cord-288670-1vlowf2n	37	11	has	have	VBZ
cord-288670-1vlowf2n	37	12	also	also	RB
cord-288670-1vlowf2n	37	13	been	be	VBN
cord-288670-1vlowf2n	37	14	widely	widely	RB
cord-288670-1vlowf2n	37	15	investigated	investigate	VBN
cord-288670-1vlowf2n	37	16	and	and	CC
cord-288670-1vlowf2n	37	17	deeply	deeply	RB
cord-288670-1vlowf2n	37	18	appreciated	appreciate	VBN
cord-288670-1vlowf2n	37	19	.	.	.
cord-288670-1vlowf2n	38	1	In	in	IN
cord-288670-1vlowf2n	38	2	the	the	DT
cord-288670-1vlowf2n	38	3	course	course	NN
cord-288670-1vlowf2n	38	4	of	of	IN
cord-288670-1vlowf2n	38	5	autophagy	autophagy	NN
cord-288670-1vlowf2n	38	6	,	,	,
cord-288670-1vlowf2n	38	7	lysosome	lysosome	NN
cord-288670-1vlowf2n	38	8	plays	play	VBZ
cord-288670-1vlowf2n	38	9	an	an	DT
cord-288670-1vlowf2n	38	10	essential	essential	JJ
cord-288670-1vlowf2n	38	11	role	role	NN
cord-288670-1vlowf2n	38	12	in	in	IN
cord-288670-1vlowf2n	38	13	the	the	DT
cord-288670-1vlowf2n	38	14	maturation	maturation	NN
cord-288670-1vlowf2n	38	15	/	/	SYM
cord-288670-1vlowf2n	38	16	degradation	degradation	NN
cord-288670-1vlowf2n	38	17	stage	stage	NN
cord-288670-1vlowf2n	38	18	of	of	IN
cord-288670-1vlowf2n	38	19	autophagy	autophagy	NN
cord-288670-1vlowf2n	38	20	,	,	,
cord-288670-1vlowf2n	38	21	as	as	IN
cord-288670-1vlowf2n	38	22	the	the	DT
cord-288670-1vlowf2n	38	23	contents	content	NNS
cord-288670-1vlowf2n	38	24	in	in	IN
cord-288670-1vlowf2n	38	25	the	the	DT
cord-288670-1vlowf2n	38	26	autophagosomes	autophagosome	NNS
cord-288670-1vlowf2n	38	27	are	be	VBP
cord-288670-1vlowf2n	38	28	eventually	eventually	RB
cord-288670-1vlowf2n	38	29	degraded	degrade	VBN
cord-288670-1vlowf2n	38	30	by	by	IN
cord-288670-1vlowf2n	38	31	lysosomes	lysosome	NNS
cord-288670-1vlowf2n	38	32	,	,	,
cord-288670-1vlowf2n	38	33	via	via	IN
cord-288670-1vlowf2n	38	34	autophagosome	autophagosome	NN
cord-288670-1vlowf2n	38	35	-	-	HYPH
cord-288670-1vlowf2n	38	36	lysosome	lysosome	NN
cord-288670-1vlowf2n	38	37	fusion	fusion	NN
cord-288670-1vlowf2n	38	38	[	[	-LRB-
cord-288670-1vlowf2n	38	39	14	14	CD
cord-288670-1vlowf2n	38	40	]	]	-RRB-
cord-288670-1vlowf2n	38	41	[	[	-LRB-
cord-288670-1vlowf2n	38	42	15	15	CD
cord-288670-1vlowf2n	38	43	]	]	-RRB-
cord-288670-1vlowf2n	38	44	[	[	-LRB-
cord-288670-1vlowf2n	38	45	16	16	CD
cord-288670-1vlowf2n	38	46	]	]	-RRB-
cord-288670-1vlowf2n	38	47	.	.	.
cord-288670-1vlowf2n	39	1	Lysosome	Lysosome	NNP
cord-288670-1vlowf2n	39	2	,	,	,
cord-288670-1vlowf2n	39	3	first	first	RB
cord-288670-1vlowf2n	39	4	discovered	discover	VBN
cord-288670-1vlowf2n	39	5	by	by	IN
cord-288670-1vlowf2n	39	6	the	the	DT
cord-288670-1vlowf2n	39	7	Nobel	Nobel	NNP
cord-288670-1vlowf2n	39	8	laureate	laureate	NN
cord-288670-1vlowf2n	39	9	Christian	Christian	NNP
cord-288670-1vlowf2n	39	10	de	de	NNP
cord-288670-1vlowf2n	39	11	Duve	Duve	NNP
cord-288670-1vlowf2n	39	12	in	in	IN
cord-288670-1vlowf2n	39	13	the	the	DT
cord-288670-1vlowf2n	39	14	1950s	1950	NNS
cord-288670-1vlowf2n	39	15	,	,	,
cord-288670-1vlowf2n	39	16	is	be	VBZ
cord-288670-1vlowf2n	39	17	the	the	DT
cord-288670-1vlowf2n	39	18	most	most	RBS
cord-288670-1vlowf2n	39	19	important	important	JJ
cord-288670-1vlowf2n	39	20	digestive	digestive	JJ
cord-288670-1vlowf2n	39	21	organelle	organelle	NN
cord-288670-1vlowf2n	39	22	present	present	JJ
cord-288670-1vlowf2n	39	23	in	in	IN
cord-288670-1vlowf2n	39	24	almost	almost	RB
cord-288670-1vlowf2n	39	25	all	all	DT
cord-288670-1vlowf2n	39	26	eukaryotic	eukaryotic	JJ
cord-288670-1vlowf2n	39	27	cells	cell	NNS
cord-288670-1vlowf2n	39	28	and	and	CC
cord-288670-1vlowf2n	39	29	with	with	IN
cord-288670-1vlowf2n	39	30	an	an	DT
cord-288670-1vlowf2n	39	31	array	array	NN
cord-288670-1vlowf2n	39	32	of	of	IN
cord-288670-1vlowf2n	39	33	important	important	JJ
cord-288670-1vlowf2n	39	34	biological	biological	JJ
cord-288670-1vlowf2n	39	35	functions	function	NNS
cord-288670-1vlowf2n	39	36	,	,	,
cord-288670-1vlowf2n	39	37	including	include	VBG
cord-288670-1vlowf2n	39	38	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	39	39	,	,	,
cord-288670-1vlowf2n	39	40	exocytosis	exocytosis	NN
cord-288670-1vlowf2n	39	41	,	,	,
cord-288670-1vlowf2n	39	42	macropinocytosis	macropinocytosis	NN
cord-288670-1vlowf2n	39	43	,	,	,
cord-288670-1vlowf2n	39	44	plasma	plasma	NN
cord-288670-1vlowf2n	39	45	membrane	membrane	NN
cord-288670-1vlowf2n	39	46	repair	repair	NN
cord-288670-1vlowf2n	39	47	,	,	,
cord-288670-1vlowf2n	39	48	defense	defense	NN
cord-288670-1vlowf2n	39	49	against	against	IN
cord-288670-1vlowf2n	39	50	pathogens	pathogen	NNS
cord-288670-1vlowf2n	39	51	,	,	,
cord-288670-1vlowf2n	39	52	cell	cell	NN
cord-288670-1vlowf2n	39	53	death	death	NN
cord-288670-1vlowf2n	39	54	,	,	,
cord-288670-1vlowf2n	39	55	signal	signal	NN
cord-288670-1vlowf2n	39	56	transduction	transduction	NN
cord-288670-1vlowf2n	39	57	,	,	,
cord-288670-1vlowf2n	39	58	and	and	CC
cord-288670-1vlowf2n	39	59	autophagy	autophagy	NN
cord-288670-1vlowf2n	39	60	[	[	-LRB-
cord-288670-1vlowf2n	39	61	14	14	CD
cord-288670-1vlowf2n	39	62	,	,	,
cord-288670-1vlowf2n	39	63	17	17	CD
cord-288670-1vlowf2n	39	64	]	]	-RRB-
cord-288670-1vlowf2n	39	65	.	.	.
cord-288670-1vlowf2n	40	1	Lysosome	Lysosome	NNP
cord-288670-1vlowf2n	40	2	is	be	VBZ
cord-288670-1vlowf2n	40	3	featured	feature	VBN
cord-288670-1vlowf2n	40	4	by	by	IN
cord-288670-1vlowf2n	40	5	its	-PRON-	PRP$
cord-288670-1vlowf2n	40	6	acidic	acidic	JJ
cord-288670-1vlowf2n	40	7	internal	internal	JJ
cord-288670-1vlowf2n	40	8	pH	ph	NN
cord-288670-1vlowf2n	40	9	which	which	WDT
cord-288670-1vlowf2n	40	10	is	be	VBZ
cord-288670-1vlowf2n	40	11	generated	generate	VBN
cord-288670-1vlowf2n	40	12	by	by	IN
cord-288670-1vlowf2n	40	13	the	the	DT
cord-288670-1vlowf2n	40	14	action	action	NN
cord-288670-1vlowf2n	40	15	of	of	IN
cord-288670-1vlowf2n	40	16	a	a	DT
cord-288670-1vlowf2n	40	17	V	V	NNP
cord-288670-1vlowf2n	40	18	-	-	HYPH
cord-288670-1vlowf2n	40	19	ATPase	ATPase	NNP
cord-288670-1vlowf2n	40	20	,	,	,
cord-288670-1vlowf2n	40	21	a	a	DT
cord-288670-1vlowf2n	40	22	proton	proton	NN
cord-288670-1vlowf2n	40	23	-	-	HYPH
cord-288670-1vlowf2n	40	24	pumping	pump	VBG
cord-288670-1vlowf2n	40	25	membrane	membrane	NN
cord-288670-1vlowf2n	40	26	protein	protein	NN
cord-288670-1vlowf2n	40	27	complex	complex	NN
cord-288670-1vlowf2n	40	28	[	[	-LRB-
cord-288670-1vlowf2n	40	29	18	18	CD
cord-288670-1vlowf2n	40	30	]	]	-RRB-
cord-288670-1vlowf2n	40	31	.	.	.
cord-288670-1vlowf2n	41	1	Lysosome	Lysosome	NNP
cord-288670-1vlowf2n	41	2	contains	contain	VBZ
cord-288670-1vlowf2n	41	3	more	more	JJR
cord-288670-1vlowf2n	41	4	than	than	IN
cord-288670-1vlowf2n	41	5	50	50	CD
cord-288670-1vlowf2n	41	6	acid	acid	NN
cord-288670-1vlowf2n	41	7	hydrolases	hydrolase	NNS
cord-288670-1vlowf2n	41	8	,	,	,
cord-288670-1vlowf2n	41	9	including	include	VBG
cord-288670-1vlowf2n	41	10	proteases	protease	NNS
cord-288670-1vlowf2n	41	11	,	,	,
cord-288670-1vlowf2n	41	12	peptidases	peptidase	NNS
cord-288670-1vlowf2n	41	13	,	,	,
cord-288670-1vlowf2n	41	14	phosphatases	phosphatase	NNS
cord-288670-1vlowf2n	41	15	,	,	,
cord-288670-1vlowf2n	41	16	nucleases	nuclease	NNS
cord-288670-1vlowf2n	41	17	,	,	,
cord-288670-1vlowf2n	41	18	glycosidases	glycosidase	NNS
cord-288670-1vlowf2n	41	19	,	,	,
cord-288670-1vlowf2n	41	20	sulfatases	sulfatases	NNPS
cord-288670-1vlowf2n	41	21	,	,	,
cord-288670-1vlowf2n	41	22	and	and	CC
cord-288670-1vlowf2n	41	23	lipases	lipase	NNS
cord-288670-1vlowf2n	41	24	designated	designate	VBD
cord-288670-1vlowf2n	41	25	for	for	IN
cord-288670-1vlowf2n	41	26	all	all	DT
cord-288670-1vlowf2n	41	27	types	type	NNS
cord-288670-1vlowf2n	41	28	of	of	IN
cord-288670-1vlowf2n	41	29	macromolecules	macromolecule	NNS
cord-288670-1vlowf2n	41	30	[	[	-LRB-
cord-288670-1vlowf2n	41	31	19	19	CD
cord-288670-1vlowf2n	41	32	]	]	-RRB-
cord-288670-1vlowf2n	41	33	.	.	.
cord-288670-1vlowf2n	42	1	On	on	IN
cord-288670-1vlowf2n	42	2	the	the	DT
cord-288670-1vlowf2n	42	3	other	other	JJ
cord-288670-1vlowf2n	42	4	hand	hand	NN
cord-288670-1vlowf2n	42	5	,	,	,
cord-288670-1vlowf2n	42	6	lysosome	lysosome	NN
cord-288670-1vlowf2n	42	7	is	be	VBZ
cord-288670-1vlowf2n	42	8	also	also	RB
cord-288670-1vlowf2n	42	9	a	a	DT
cord-288670-1vlowf2n	42	10	key	key	JJ
cord-288670-1vlowf2n	42	11	component	component	NN
cord-288670-1vlowf2n	42	12	of	of	IN
cord-288670-1vlowf2n	42	13	the	the	DT
cord-288670-1vlowf2n	42	14	endocytic	endocytic	JJ
cord-288670-1vlowf2n	42	15	pathway	pathway	NN
cord-288670-1vlowf2n	42	16	,	,	,
cord-288670-1vlowf2n	42	17	also	also	RB
cord-288670-1vlowf2n	42	18	termed	term	VBD
cord-288670-1vlowf2n	42	19	as	as	IN
cord-288670-1vlowf2n	42	20	the	the	DT
cord-288670-1vlowf2n	42	21	endolysosomal	endolysosomal	JJ
cord-288670-1vlowf2n	42	22	network	network	NN
cord-288670-1vlowf2n	42	23	[	[	-LRB-
cord-288670-1vlowf2n	42	24	20	20	CD
cord-288670-1vlowf2n	42	25	]	]	-RRB-
cord-288670-1vlowf2n	42	26	(	(	-LRB-
cord-288670-1vlowf2n	42	27	Figure	figure	NN
cord-288670-1vlowf2n	42	28	1	1	CD
cord-288670-1vlowf2n	42	29	)	)	-RRB-
cord-288670-1vlowf2n	42	30	.	.	.
cord-288670-1vlowf2n	43	1	In	in	IN
cord-288670-1vlowf2n	43	2	addition	addition	NN
cord-288670-1vlowf2n	43	3	to	to	TO
cord-288670-1vlowf2n	43	4	autophagy	autophagy	VB
cord-288670-1vlowf2n	43	5	as	as	IN
cord-288670-1vlowf2n	43	6	described	describe	VBN
cord-288670-1vlowf2n	43	7	above	above	RB
cord-288670-1vlowf2n	43	8	,	,	,
cord-288670-1vlowf2n	43	9	lysosome	lysosome	NN
cord-288670-1vlowf2n	43	10	receives	receive	VBZ
cord-288670-1vlowf2n	43	11	cargos	cargo	NNS
cord-288670-1vlowf2n	43	12	from	from	IN
cord-288670-1vlowf2n	43	13	other	other	JJ
cord-288670-1vlowf2n	43	14	processes	process	NNS
cord-288670-1vlowf2n	43	15	including	include	VBG
cord-288670-1vlowf2n	43	16	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	43	17	through	through	IN
cord-288670-1vlowf2n	43	18	the	the	DT
cord-288670-1vlowf2n	43	19	endocytic	endocytic	JJ
cord-288670-1vlowf2n	43	20	pathway	pathway	NN
cord-288670-1vlowf2n	43	21	.	.	.
cord-288670-1vlowf2n	44	1	Briefly	briefly	RB
cord-288670-1vlowf2n	44	2	,	,	,
cord-288670-1vlowf2n	44	3	following	follow	VBG
cord-288670-1vlowf2n	44	4	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	44	5	,	,	,
cord-288670-1vlowf2n	44	6	internalized	internalize	VBN
cord-288670-1vlowf2n	44	7	cargos	cargo	NNS
cord-288670-1vlowf2n	44	8	first	first	RB
cord-288670-1vlowf2n	44	9	enter	enter	VB
cord-288670-1vlowf2n	44	10	the	the	DT
cord-288670-1vlowf2n	44	11	early	early	JJ
cord-288670-1vlowf2n	44	12	endosomes	endosome	NNS
cord-288670-1vlowf2n	44	13	(	(	-LRB-
cord-288670-1vlowf2n	44	14	EE	EE	NNP
cord-288670-1vlowf2n	44	15	)	)	-RRB-
cord-288670-1vlowf2n	44	16	where	where	WRB
cord-288670-1vlowf2n	44	17	the	the	DT
cord-288670-1vlowf2n	44	18	cargos	cargo	NNS
cord-288670-1vlowf2n	44	19	are	be	VBP
cord-288670-1vlowf2n	44	20	sorted	sort	VBN
cord-288670-1vlowf2n	44	21	for	for	IN
cord-288670-1vlowf2n	44	22	two	two	CD
cord-288670-1vlowf2n	44	23	destinations	destination	NNS
cord-288670-1vlowf2n	44	24	:	:	:
cord-288670-1vlowf2n	44	25	they	-PRON-	PRP
cord-288670-1vlowf2n	44	26	are	be	VBP
cord-288670-1vlowf2n	44	27	either	either	RB
cord-288670-1vlowf2n	44	28	retrieved	retrieve	VBN
cord-288670-1vlowf2n	44	29	for	for	IN
cord-288670-1vlowf2n	44	30	recycling	recycling	NN
cord-288670-1vlowf2n	44	31	to	to	IN
cord-288670-1vlowf2n	44	32	the	the	DT
cord-288670-1vlowf2n	44	33	plasma	plasma	NN
cord-288670-1vlowf2n	44	34	membrane	membrane	NN
cord-288670-1vlowf2n	44	35	/	/	,
cord-288670-1vlowf2n	44	36	the	the	DT
cord-288670-1vlowf2n	44	37	secretory	secretory	JJ
cord-288670-1vlowf2n	44	38	pathway	pathway	NN
cord-288670-1vlowf2n	44	39	,	,	,
cord-288670-1vlowf2n	44	40	or	or	CC
cord-288670-1vlowf2n	44	41	are	be	VBP
cord-288670-1vlowf2n	44	42	delivered	deliver	VBN
cord-288670-1vlowf2n	44	43	to	to	IN
cord-288670-1vlowf2n	44	44	the	the	DT
cord-288670-1vlowf2n	44	45	late	late	JJ
cord-288670-1vlowf2n	44	46	endosome	endosome	NN
cord-288670-1vlowf2n	44	47	(	(	-LRB-
cord-288670-1vlowf2n	44	48	LE	LE	NNP
cord-288670-1vlowf2n	44	49	)	)	-RRB-
cord-288670-1vlowf2n	44	50	and	and	CC
cord-288670-1vlowf2n	44	51	then	then	RB
cord-288670-1vlowf2n	44	52	fuse	fuse	VB
cord-288670-1vlowf2n	44	53	with	with	IN
cord-288670-1vlowf2n	44	54	lysosome	lysosome	NN
cord-288670-1vlowf2n	44	55	for	for	IN
cord-288670-1vlowf2n	44	56	degradation	degradation	NN
cord-288670-1vlowf2n	44	57	[	[	-LRB-
cord-288670-1vlowf2n	44	58	20	20	CD
cord-288670-1vlowf2n	44	59	,	,	,
cord-288670-1vlowf2n	44	60	21	21	CD
cord-288670-1vlowf2n	44	61	]	]	-RRB-
cord-288670-1vlowf2n	44	62	.	.	.
cord-288670-1vlowf2n	45	1	The	the	DT
cord-288670-1vlowf2n	45	2	main	main	JJ
cord-288670-1vlowf2n	45	3	biological	biological	JJ
cord-288670-1vlowf2n	45	4	functions	function	NNS
cord-288670-1vlowf2n	45	5	of	of	IN
cord-288670-1vlowf2n	45	6	the	the	DT
cord-288670-1vlowf2n	45	7	endocytic	endocytic	JJ
cord-288670-1vlowf2n	45	8	pathway	pathway	NN
cord-288670-1vlowf2n	45	9	are	be	VBP
cord-288670-1vlowf2n	45	10	for	for	IN
cord-288670-1vlowf2n	45	11	retrieval	retrieval	NN
cord-288670-1vlowf2n	45	12	and	and	CC
cord-288670-1vlowf2n	45	13	recycling	recycling	NN
cord-288670-1vlowf2n	45	14	of	of	IN
cord-288670-1vlowf2n	45	15	internalized	internalize	VBN
cord-288670-1vlowf2n	45	16	cargo	cargo	NN
cord-288670-1vlowf2n	45	17	proteins	protein	NNS
cord-288670-1vlowf2n	45	18	,	,	,
cord-288670-1vlowf2n	45	19	and	and	CC
cord-288670-1vlowf2n	45	20	such	such	JJ
cord-288670-1vlowf2n	45	21	functions	function	NNS
cord-288670-1vlowf2n	45	22	are	be	VBP
cord-288670-1vlowf2n	45	23	known	know	VBN
cord-288670-1vlowf2n	45	24	to	to	TO
cord-288670-1vlowf2n	45	25	play	play	VB
cord-288670-1vlowf2n	45	26	critical	critical	JJ
cord-288670-1vlowf2n	45	27	roles	role	NNS
cord-288670-1vlowf2n	45	28	in	in	IN
cord-288670-1vlowf2n	45	29	the	the	DT
cord-288670-1vlowf2n	45	30	pathology	pathology	NN
cord-288670-1vlowf2n	45	31	of	of	IN
cord-288670-1vlowf2n	45	32	important	important	JJ
cord-288670-1vlowf2n	45	33	human	human	JJ
cord-288670-1vlowf2n	45	34	diseases	disease	NNS
cord-288670-1vlowf2n	45	35	,	,	,
cord-288670-1vlowf2n	45	36	in	in	IN
cord-288670-1vlowf2n	45	37	particularly	particularly	RB
cord-288670-1vlowf2n	45	38	neurodegenerative	neurodegenerative	JJ
cord-288670-1vlowf2n	45	39	diseases	disease	NNS
cord-288670-1vlowf2n	45	40	and	and	CC
cord-288670-1vlowf2n	45	41	viral	viral	JJ
cord-288670-1vlowf2n	45	42	infection	infection	NN
cord-288670-1vlowf2n	45	43	[	[	-LRB-
cord-288670-1vlowf2n	45	44	22	22	CD
cord-288670-1vlowf2n	45	45	,	,	,
cord-288670-1vlowf2n	45	46	23	23	CD
cord-288670-1vlowf2n	45	47	]	]	-RRB-
cord-288670-1vlowf2n	45	48	.	.	.
cord-288670-1vlowf2n	46	1	In	in	IN
cord-288670-1vlowf2n	46	2	the	the	DT
cord-288670-1vlowf2n	46	3	past	past	JJ
cord-288670-1vlowf2n	46	4	one	one	NN
cord-288670-1vlowf2n	46	5	and	and	CC
cord-288670-1vlowf2n	46	6	a	a	DT
cord-288670-1vlowf2n	46	7	half	half	NN
cord-288670-1vlowf2n	46	8	decades	decade	NNS
cord-288670-1vlowf2n	46	9	,	,	,
cord-288670-1vlowf2n	46	10	the	the	DT
cord-288670-1vlowf2n	46	11	implication	implication	NN
cord-288670-1vlowf2n	46	12	of	of	IN
cord-288670-1vlowf2n	46	13	autophagy	autophagy	NN
cord-288670-1vlowf2n	46	14	in	in	IN
cord-288670-1vlowf2n	46	15	CoV	cov	NN
cord-288670-1vlowf2n	46	16	infection	infection	NN
cord-288670-1vlowf2n	46	17	has	have	VBZ
cord-288670-1vlowf2n	46	18	attracted	attract	VBN
cord-288670-1vlowf2n	46	19	substantial	substantial	JJ
cord-288670-1vlowf2n	46	20	attention	attention	NN
cord-288670-1vlowf2n	46	21	,	,	,
cord-288670-1vlowf2n	46	22	Figure	figure	NN
cord-288670-1vlowf2n	46	23	1	1	CD
cord-288670-1vlowf2n	46	24	.	.	.
cord-288670-1vlowf2n	47	1	Involvement	involvement	NN
cord-288670-1vlowf2n	47	2	of	of	IN
cord-288670-1vlowf2n	47	3	the	the	DT
cord-288670-1vlowf2n	47	4	endocytic	endocytic	JJ
cord-288670-1vlowf2n	47	5	pathway	pathway	NN
cord-288670-1vlowf2n	47	6	and	and	CC
cord-288670-1vlowf2n	47	7	autophagy	autophagy	NN
cord-288670-1vlowf2n	47	8	in	in	IN
cord-288670-1vlowf2n	47	9	the	the	DT
cord-288670-1vlowf2n	47	10	entry	entry	NN
cord-288670-1vlowf2n	47	11	and	and	CC
cord-288670-1vlowf2n	47	12	replication	replication	NN
cord-288670-1vlowf2n	47	13	of	of	IN
cord-288670-1vlowf2n	47	14	CoVs	CoVs	NNP
cord-288670-1vlowf2n	47	15	in	in	IN
cord-288670-1vlowf2n	47	16	host	host	NN
cord-288670-1vlowf2n	47	17	cells	cell	NNS
cord-288670-1vlowf2n	47	18	.	.	.
cord-288670-1vlowf2n	48	1	Entry	entry	NN
cord-288670-1vlowf2n	48	2	of	of	IN
cord-288670-1vlowf2n	48	3	CoVs	CoVs	NNP
cord-288670-1vlowf2n	48	4	into	into	IN
cord-288670-1vlowf2n	48	5	the	the	DT
cord-288670-1vlowf2n	48	6	host	host	NN
cord-288670-1vlowf2n	48	7	cells	cell	NNS
cord-288670-1vlowf2n	48	8	is	be	VBZ
cord-288670-1vlowf2n	48	9	mainly	mainly	RB
cord-288670-1vlowf2n	48	10	mediated	mediate	VBN
cord-288670-1vlowf2n	48	11	by	by	IN
cord-288670-1vlowf2n	48	12	the	the	DT
cord-288670-1vlowf2n	48	13	endocytic	endocytic	JJ
cord-288670-1vlowf2n	48	14	pathway	pathway	NN
cord-288670-1vlowf2n	48	15	,	,	,
cord-288670-1vlowf2n	48	16	meanwhile	meanwhile	RB
cord-288670-1vlowf2n	48	17	the	the	DT
cord-288670-1vlowf2n	48	18	autophagy	autophagy	NN
cord-288670-1vlowf2n	48	19	has	have	VBZ
cord-288670-1vlowf2n	48	20	also	also	RB
cord-288670-1vlowf2n	48	21	been	be	VBN
cord-288670-1vlowf2n	48	22	implicated	implicate	VBN
cord-288670-1vlowf2n	48	23	in	in	IN
cord-288670-1vlowf2n	48	24	the	the	DT
cord-288670-1vlowf2n	48	25	viral	viral	JJ
cord-288670-1vlowf2n	48	26	replication	replication	NN
cord-288670-1vlowf2n	48	27	in	in	IN
cord-288670-1vlowf2n	48	28	the	the	DT
cord-288670-1vlowf2n	48	29	cells	cell	NNS
cord-288670-1vlowf2n	48	30	,	,	,
cord-288670-1vlowf2n	48	31	a	a	DT
cord-288670-1vlowf2n	48	32	process	process	NN
cord-288670-1vlowf2n	48	33	partly	partly	RB
cord-288670-1vlowf2n	48	34	related	relate	VBN
cord-288670-1vlowf2n	48	35	to	to	IN
cord-288670-1vlowf2n	48	36	the	the	DT
cord-288670-1vlowf2n	48	37	formation	formation	NN
cord-288670-1vlowf2n	48	38	of	of	IN
cord-288670-1vlowf2n	48	39	DMV	DMV	NNP
cord-288670-1vlowf2n	48	40	in	in	IN
cord-288670-1vlowf2n	48	41	the	the	DT
cord-288670-1vlowf2n	48	42	host	host	NN
cord-288670-1vlowf2n	48	43	cells	cell	NNS
cord-288670-1vlowf2n	48	44	.	.	.
cord-288670-1vlowf2n	49	1	As	as	IN
cord-288670-1vlowf2n	49	2	a	a	DT
cord-288670-1vlowf2n	49	3	result	result	NN
cord-288670-1vlowf2n	49	4	,	,	,
cord-288670-1vlowf2n	49	5	several	several	JJ
cord-288670-1vlowf2n	49	6	groups	group	NNS
cord-288670-1vlowf2n	49	7	of	of	IN
cord-288670-1vlowf2n	49	8	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	49	9	including	include	VBG
cord-288670-1vlowf2n	49	10	the	the	DT
cord-288670-1vlowf2n	49	11	lysosomotropic	lysosomotropic	JJ
cord-288670-1vlowf2n	49	12	agents	agent	NNS
cord-288670-1vlowf2n	49	13	such	such	JJ
cord-288670-1vlowf2n	49	14	as	as	IN
cord-288670-1vlowf2n	49	15	CQ	CQ	NNP
cord-288670-1vlowf2n	49	16	and	and	CC
cord-288670-1vlowf2n	49	17	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	49	18	for	for	IN
cord-288670-1vlowf2n	49	19	clathrin	clathrin	NN
cord-288670-1vlowf2n	49	20	-	-	HYPH
cord-288670-1vlowf2n	49	21	mediated	mediate	VBN
cord-288670-1vlowf2n	49	22	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	49	23	such	such	JJ
cord-288670-1vlowf2n	49	24	as	as	IN
cord-288670-1vlowf2n	49	25	chlorpromazine	chlorpromazine	NN
cord-288670-1vlowf2n	49	26	have	have	VBP
cord-288670-1vlowf2n	49	27	been	be	VBN
cord-288670-1vlowf2n	49	28	proposed	propose	VBN
cord-288670-1vlowf2n	49	29	to	to	TO
cord-288670-1vlowf2n	49	30	have	have	VB
cord-288670-1vlowf2n	49	31	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	49	32	efficacy	efficacy	NN
cord-288670-1vlowf2n	49	33	against	against	IN
cord-288670-1vlowf2n	49	34	CoVs	CoVs	NNP
cord-288670-1vlowf2n	49	35	-	-	HYPH
cord-288670-1vlowf2n	49	36	induced	induce	VBN
cord-288670-1vlowf2n	49	37	diseases	disease	NNS
cord-288670-1vlowf2n	49	38	including	include	VBG
cord-288670-1vlowf2n	49	39	COVID-19	covid-19	VBP
cord-288670-1vlowf2n	49	40	.	.	.
cord-288670-1vlowf2n	50	1	probably	probably	RB
cord-288670-1vlowf2n	50	2	due	due	IN
cord-288670-1vlowf2n	50	3	to	to	IN
cord-288670-1vlowf2n	50	4	the	the	DT
cord-288670-1vlowf2n	50	5	SARS	SARS	NNP
cord-288670-1vlowf2n	50	6	outbreak	outbreak	NN
cord-288670-1vlowf2n	50	7	in	in	IN
cord-288670-1vlowf2n	50	8	2002	2002	CD
cord-288670-1vlowf2n	50	9	-	-	SYM
cord-288670-1vlowf2n	50	10	2003	2003	CD
cord-288670-1vlowf2n	50	11	and	and	CC
cord-288670-1vlowf2n	50	12	the	the	DT
cord-288670-1vlowf2n	50	13	emerging	emerge	VBG
cord-288670-1vlowf2n	50	14	field	field	NN
cord-288670-1vlowf2n	50	15	of	of	IN
cord-288670-1vlowf2n	50	16	autophagy	autophagy	NN
cord-288670-1vlowf2n	50	17	research	research	NN
cord-288670-1vlowf2n	50	18	at	at	IN
cord-288670-1vlowf2n	50	19	the	the	DT
cord-288670-1vlowf2n	50	20	same	same	JJ
cord-288670-1vlowf2n	50	21	period	period	NN
cord-288670-1vlowf2n	50	22	.	.	.
cord-288670-1vlowf2n	51	1	At	at	IN
cord-288670-1vlowf2n	51	2	present	present	JJ
cord-288670-1vlowf2n	51	3	,	,	,
cord-288670-1vlowf2n	51	4	various	various	JJ
cord-288670-1vlowf2n	51	5	reports	report	NNS
cord-288670-1vlowf2n	51	6	have	have	VBP
cord-288670-1vlowf2n	51	7	converged	converge	VBN
cord-288670-1vlowf2n	51	8	onto	onto	IN
cord-288670-1vlowf2n	51	9	two	two	CD
cord-288670-1vlowf2n	51	10	important	important	JJ
cord-288670-1vlowf2n	51	11	questions	question	NNS
cord-288670-1vlowf2n	51	12	:	:	:
cord-288670-1vlowf2n	51	13	whether	whether	IN
cord-288670-1vlowf2n	51	14	CoV	cov	NN
cord-288670-1vlowf2n	51	15	induces	induce	VBZ
cord-288670-1vlowf2n	51	16	autophagy	autophagy	NN
cord-288670-1vlowf2n	51	17	and	and	CC
cord-288670-1vlowf2n	51	18	whether	whether	IN
cord-288670-1vlowf2n	51	19	the	the	DT
cord-288670-1vlowf2n	51	20	autophagy	autophagy	NN
cord-288670-1vlowf2n	51	21	machinery	machinery	NN
cord-288670-1vlowf2n	51	22	or	or	CC
cord-288670-1vlowf2n	51	23	ATG	ATG	NNP
cord-288670-1vlowf2n	51	24	proteins	protein	NNS
cord-288670-1vlowf2n	51	25	are	be	VBP
cord-288670-1vlowf2n	51	26	involved	involve	VBN
cord-288670-1vlowf2n	51	27	in	in	IN
cord-288670-1vlowf2n	51	28	the	the	DT
cord-288670-1vlowf2n	51	29	infection	infection	NN
cord-288670-1vlowf2n	51	30	and	and	CC
cord-288670-1vlowf2n	51	31	replication	replication	NN
cord-288670-1vlowf2n	51	32	of	of	IN
cord-288670-1vlowf2n	51	33	CoVs	CoVs	NNP
cord-288670-1vlowf2n	51	34	.	.	.
cord-288670-1vlowf2n	52	1	The	the	DT
cord-288670-1vlowf2n	52	2	first	first	JJ
cord-288670-1vlowf2n	52	3	report	report	NN
cord-288670-1vlowf2n	52	4	demonstrating	demonstrate	VBG
cord-288670-1vlowf2n	52	5	the	the	DT
cord-288670-1vlowf2n	52	6	involvement	involvement	NN
cord-288670-1vlowf2n	52	7	of	of	IN
cord-288670-1vlowf2n	52	8	autophagy	autophagy	NN
cord-288670-1vlowf2n	52	9	in	in	IN
cord-288670-1vlowf2n	52	10	viral	viral	JJ
cord-288670-1vlowf2n	52	11	replication	replication	NN
cord-288670-1vlowf2n	52	12	was	be	VBD
cord-288670-1vlowf2n	52	13	based	base	VBN
cord-288670-1vlowf2n	52	14	on	on	IN
cord-288670-1vlowf2n	52	15	MHV	MHV	NNP
cord-288670-1vlowf2n	52	16	[	[	-LRB-
cord-288670-1vlowf2n	52	17	24	24	CD
cord-288670-1vlowf2n	52	18	]	]	-RRB-
cord-288670-1vlowf2n	52	19	,	,	,
cord-288670-1vlowf2n	52	20	in	in	IN
cord-288670-1vlowf2n	52	21	which	which	WDT
cord-288670-1vlowf2n	52	22	the	the	DT
cord-288670-1vlowf2n	52	23	authors	author	NNS
cord-288670-1vlowf2n	52	24	made	make	VBD
cord-288670-1vlowf2n	52	25	several	several	JJ
cord-288670-1vlowf2n	52	26	important	important	JJ
cord-288670-1vlowf2n	52	27	observations	observation	NNS
cord-288670-1vlowf2n	52	28	.	.	.
cord-288670-1vlowf2n	53	1	First	first	RB
cord-288670-1vlowf2n	53	2	,	,	,
cord-288670-1vlowf2n	53	3	MHV	MHV	NNP
cord-288670-1vlowf2n	53	4	induced	induce	VBD
cord-288670-1vlowf2n	53	5	the	the	DT
cord-288670-1vlowf2n	53	6	formation	formation	NN
cord-288670-1vlowf2n	53	7	of	of	IN
cord-288670-1vlowf2n	53	8	double	double	JJ
cord-288670-1vlowf2n	53	9	-	-	HYPH
cord-288670-1vlowf2n	53	10	membrane	membrane	NN
cord-288670-1vlowf2n	53	11	vesicles	vesicle	NNS
cord-288670-1vlowf2n	53	12	(	(	-LRB-
cord-288670-1vlowf2n	53	13	DMVs	dmv	NNS
cord-288670-1vlowf2n	53	14	)	)	-RRB-
cord-288670-1vlowf2n	53	15	,	,	,
cord-288670-1vlowf2n	53	16	with	with	IN
cord-288670-1vlowf2n	53	17	resemblance	resemblance	NN
cord-288670-1vlowf2n	53	18	to	to	IN
cord-288670-1vlowf2n	53	19	autophagosome	autophagosome	NNP
cord-288670-1vlowf2n	53	20	,	,	,
cord-288670-1vlowf2n	53	21	a	a	DT
cord-288670-1vlowf2n	53	22	hallmark	hallmark	NN
cord-288670-1vlowf2n	53	23	of	of	IN
cord-288670-1vlowf2n	53	24	autophagy	autophagy	NN
cord-288670-1vlowf2n	53	25	.	.	.
cord-288670-1vlowf2n	54	1	Second	second	RB
cord-288670-1vlowf2n	54	2	,	,	,
cord-288670-1vlowf2n	54	3	the	the	DT
cord-288670-1vlowf2n	54	4	viral	viral	JJ
cord-288670-1vlowf2n	54	5	replication	replication	NN
cord-288670-1vlowf2n	54	6	complexes	complex	NNS
cord-288670-1vlowf2n	54	7	at	at	IN
cord-288670-1vlowf2n	54	8	DMVs	dmv	NNS
cord-288670-1vlowf2n	54	9	co	co	VBD
cord-288670-1vlowf2n	54	10	-	-	VBN
cord-288670-1vlowf2n	54	11	localized	localize	VBN
cord-288670-1vlowf2n	54	12	with	with	IN
cord-288670-1vlowf2n	54	13	the	the	DT
cord-288670-1vlowf2n	54	14	autophagy	autophagy	NN
cord-288670-1vlowf2n	54	15	proteins	protein	NNS
cord-288670-1vlowf2n	54	16	,	,	,
cord-288670-1vlowf2n	54	17	LC3	LC3	NNP
cord-288670-1vlowf2n	54	18	and	and	CC
cord-288670-1vlowf2n	54	19	ATG12	ATG12	NNP
cord-288670-1vlowf2n	54	20	.	.	.
cord-288670-1vlowf2n	55	1	Third	third	JJ
cord-288670-1vlowf2n	55	2	and	and	CC
cord-288670-1vlowf2n	55	3	more	more	RBR
cord-288670-1vlowf2n	55	4	importantly	importantly	RB
cord-288670-1vlowf2n	55	5	,	,	,
cord-288670-1vlowf2n	55	6	MHV	MHV	NNP
cord-288670-1vlowf2n	55	7	replication	replication	NN
cord-288670-1vlowf2n	55	8	was	be	VBD
cord-288670-1vlowf2n	55	9	impaired	impair	VBN
cord-288670-1vlowf2n	55	10	in	in	IN
cord-288670-1vlowf2n	55	11	ATG5	atg5	JJ
cord-288670-1vlowf2n	55	12	knockout	knockout	NN
cord-288670-1vlowf2n	55	13	embryonic	embryonic	JJ
cord-288670-1vlowf2n	55	14	stem	stem	NN
cord-288670-1vlowf2n	55	15	cells	cell	NNS
cord-288670-1vlowf2n	55	16	.	.	.
cord-288670-1vlowf2n	56	1	Therefore	therefore	RB
cord-288670-1vlowf2n	56	2	,	,	,
cord-288670-1vlowf2n	56	3	the	the	DT
cord-288670-1vlowf2n	56	4	authors	author	NNS
cord-288670-1vlowf2n	56	5	concluded	conclude	VBD
cord-288670-1vlowf2n	56	6	that	that	IN
cord-288670-1vlowf2n	56	7	autophagy	autophagy	NN
cord-288670-1vlowf2n	56	8	is	be	VBZ
cord-288670-1vlowf2n	56	9	implicated	implicate	VBN
cord-288670-1vlowf2n	56	10	in	in	IN
cord-288670-1vlowf2n	56	11	the	the	DT
cord-288670-1vlowf2n	56	12	formation	formation	NN
cord-288670-1vlowf2n	56	13	of	of	IN
cord-288670-1vlowf2n	56	14	DMV	DMV	NNP
cord-288670-1vlowf2n	56	15	as	as	RB
cord-288670-1vlowf2n	56	16	well	well	RB
cord-288670-1vlowf2n	56	17	as	as	IN
cord-288670-1vlowf2n	56	18	in	in	IN
cord-288670-1vlowf2n	56	19	the	the	DT
cord-288670-1vlowf2n	56	20	replication	replication	NN
cord-288670-1vlowf2n	56	21	of	of	IN
cord-288670-1vlowf2n	56	22	MHV	MHV	NNP
cord-288670-1vlowf2n	56	23	[	[	-LRB-
cord-288670-1vlowf2n	56	24	24	24	CD
cord-288670-1vlowf2n	56	25	]	]	-RRB-
cord-288670-1vlowf2n	56	26	.	.	.
cord-288670-1vlowf2n	57	1	In	in	IN
cord-288670-1vlowf2n	57	2	a	a	DT
cord-288670-1vlowf2n	57	3	follow	follow	NN
cord-288670-1vlowf2n	57	4	-	-	HYPH
cord-288670-1vlowf2n	57	5	up	up	NN
cord-288670-1vlowf2n	57	6	study	study	NN
cord-288670-1vlowf2n	57	7	,	,	,
cord-288670-1vlowf2n	57	8	the	the	DT
cord-288670-1vlowf2n	57	9	same	same	JJ
cord-288670-1vlowf2n	57	10	group	group	NN
cord-288670-1vlowf2n	57	11	also	also	RB
cord-288670-1vlowf2n	57	12	examined	examine	VBD
cord-288670-1vlowf2n	57	13	the	the	DT
cord-288670-1vlowf2n	57	14	SARS	SARS	NNP
cord-288670-1vlowf2n	57	15	-	-	HYPH
cord-288670-1vlowf2n	57	16	CoVs	CoVs	NNP
cord-288670-1vlowf2n	57	17	and	and	CC
cord-288670-1vlowf2n	57	18	found	find	VBD
cord-288670-1vlowf2n	57	19	similar	similar	JJ
cord-288670-1vlowf2n	57	20	colocalization	colocalization	NN
cord-288670-1vlowf2n	57	21	of	of	IN
cord-288670-1vlowf2n	57	22	the	the	DT
cord-288670-1vlowf2n	57	23	key	key	JJ
cord-288670-1vlowf2n	57	24	viral	viral	JJ
cord-288670-1vlowf2n	57	25	replication	replication	NN
cord-288670-1vlowf2n	57	26	proteins	protein	NNS
cord-288670-1vlowf2n	57	27	with	with	IN
cord-288670-1vlowf2n	57	28	endogenous	endogenous	JJ
cord-288670-1vlowf2n	57	29	LC3	lc3	NN
cord-288670-1vlowf2n	57	30	,	,	,
cord-288670-1vlowf2n	57	31	a	a	DT
cord-288670-1vlowf2n	57	32	protein	protein	NN
cord-288670-1vlowf2n	57	33	marker	marker	NN
cord-288670-1vlowf2n	57	34	for	for	IN
cord-288670-1vlowf2n	57	35	autophagosome	autophagosome	NNP
cord-288670-1vlowf2n	57	36	[	[	-LRB-
cord-288670-1vlowf2n	57	37	25	25	CD
cord-288670-1vlowf2n	57	38	]	]	-RRB-
cord-288670-1vlowf2n	57	39	,	,	,
cord-288670-1vlowf2n	57	40	suggesting	suggest	VBG
cord-288670-1vlowf2n	57	41	a	a	DT
cord-288670-1vlowf2n	57	42	similar	similar	JJ
cord-288670-1vlowf2n	57	43	function	function	NN
cord-288670-1vlowf2n	57	44	of	of	IN
cord-288670-1vlowf2n	57	45	autophagy	autophagy	NN
cord-288670-1vlowf2n	57	46	in	in	IN
cord-288670-1vlowf2n	57	47	the	the	DT
cord-288670-1vlowf2n	57	48	replication	replication	NN
cord-288670-1vlowf2n	57	49	of	of	IN
cord-288670-1vlowf2n	57	50	SARS	SARS	NNP
cord-288670-1vlowf2n	57	51	-	-	HYPH
cord-288670-1vlowf2n	57	52	CoVs	CoVs	NNP
cord-288670-1vlowf2n	57	53	.	.	.
cord-288670-1vlowf2n	58	1	Cottam	Cottam	NNP
cord-288670-1vlowf2n	58	2	et	et	NNP
cord-288670-1vlowf2n	58	3	al	al	NNP
cord-288670-1vlowf2n	58	4	used	use	VBD
cord-288670-1vlowf2n	58	5	another	another	DT
cord-288670-1vlowf2n	58	6	CoV	cov	NN
cord-288670-1vlowf2n	58	7	(	(	-LRB-
cord-288670-1vlowf2n	58	8	infectious	infectious	JJ
cord-288670-1vlowf2n	58	9	bronchitis	bronchitis	NN
cord-288670-1vlowf2n	58	10	virus	virus	NN
cord-288670-1vlowf2n	58	11	,	,	,
cord-288670-1vlowf2n	58	12	IBV	IBV	NNP
cord-288670-1vlowf2n	58	13	)	)	-RRB-
cord-288670-1vlowf2n	58	14	and	and	CC
cord-288670-1vlowf2n	58	15	found	find	VBD
cord-288670-1vlowf2n	58	16	that	that	IN
cord-288670-1vlowf2n	58	17	one	one	CD
cord-288670-1vlowf2n	58	18	of	of	IN
cord-288670-1vlowf2n	58	19	the	the	DT
cord-288670-1vlowf2n	58	20	key	key	JJ
cord-288670-1vlowf2n	58	21	viral	viral	JJ
cord-288670-1vlowf2n	58	22	replicase	replicase	NNP
cord-288670-1vlowf2n	58	23	protein	protein	NNP
cord-288670-1vlowf2n	58	24	nsp6	nsp6	NNP
cord-288670-1vlowf2n	58	25	is	be	VBZ
cord-288670-1vlowf2n	58	26	capable	capable	JJ
cord-288670-1vlowf2n	58	27	of	of	IN
cord-288670-1vlowf2n	58	28	inducing	induce	VBG
cord-288670-1vlowf2n	58	29	autophagy	autophagy	NN
cord-288670-1vlowf2n	58	30	[	[	-LRB-
cord-288670-1vlowf2n	58	31	26	26	CD
cord-288670-1vlowf2n	58	32	]	]	-RRB-
cord-288670-1vlowf2n	58	33	.	.	.
cord-288670-1vlowf2n	59	1	Notably	notably	RB
cord-288670-1vlowf2n	59	2	,	,	,
cord-288670-1vlowf2n	59	3	this	this	DT
cord-288670-1vlowf2n	59	4	nsp6	nsp6	NN
cord-288670-1vlowf2n	59	5	also	also	RB
cord-288670-1vlowf2n	59	6	presents	present	VBZ
cord-288670-1vlowf2n	59	7	in	in	IN
cord-288670-1vlowf2n	59	8	MHV	MHV	NNP
cord-288670-1vlowf2n	59	9	and	and	CC
cord-288670-1vlowf2n	59	10	SARS	SARS	NNP
cord-288670-1vlowf2n	59	11	-	-	HYPH
cord-288670-1vlowf2n	59	12	CoV	CoV	NNP
cord-288670-1vlowf2n	59	13	,	,	,
cord-288670-1vlowf2n	59	14	and	and	CC
cord-288670-1vlowf2n	59	15	thus	thus	RB
cord-288670-1vlowf2n	59	16	it	-PRON-	PRP
cord-288670-1vlowf2n	59	17	would	would	MD
cord-288670-1vlowf2n	59	18	be	be	VB
cord-288670-1vlowf2n	59	19	of	of	IN
cord-288670-1vlowf2n	59	20	interest	interest	NN
cord-288670-1vlowf2n	59	21	to	to	TO
cord-288670-1vlowf2n	59	22	further	further	RB
cord-288670-1vlowf2n	59	23	test	test	VB
cord-288670-1vlowf2n	59	24	the	the	DT
cord-288670-1vlowf2n	59	25	effects	effect	NNS
cord-288670-1vlowf2n	59	26	of	of	IN
cord-288670-1vlowf2n	59	27	nsp6	nsp6	NN
cord-288670-1vlowf2n	59	28	in	in	IN
cord-288670-1vlowf2n	59	29	these	these	DT
cord-288670-1vlowf2n	59	30	two	two	CD
cord-288670-1vlowf2n	59	31	CoVs	cov	NNS
cord-288670-1vlowf2n	59	32	on	on	IN
cord-288670-1vlowf2n	59	33	autophagy	autophagy	NN
cord-288670-1vlowf2n	59	34	.	.	.
cord-288670-1vlowf2n	60	1	However	however	RB
cord-288670-1vlowf2n	60	2	,	,	,
cord-288670-1vlowf2n	60	3	several	several	JJ
cord-288670-1vlowf2n	60	4	subsequent	subsequent	JJ
cord-288670-1vlowf2n	60	5	studies	study	NNS
cord-288670-1vlowf2n	60	6	have	have	VBP
cord-288670-1vlowf2n	60	7	challenged	challenge	VBN
cord-288670-1vlowf2n	60	8	the	the	DT
cord-288670-1vlowf2n	60	9	notion	notion	NN
cord-288670-1vlowf2n	60	10	that	that	IN
cord-288670-1vlowf2n	60	11	autophagy	autophagy	NN
cord-288670-1vlowf2n	60	12	is	be	VBZ
cord-288670-1vlowf2n	60	13	implicated	implicate	VBN
cord-288670-1vlowf2n	60	14	in	in	IN
cord-288670-1vlowf2n	60	15	CoV	cov	NN
cord-288670-1vlowf2n	60	16	infection	infection	NN
cord-288670-1vlowf2n	60	17	.	.	.
cord-288670-1vlowf2n	61	1	For	for	IN
cord-288670-1vlowf2n	61	2	instance	instance	NN
cord-288670-1vlowf2n	61	3	,	,	,
cord-288670-1vlowf2n	61	4	in	in	IN
cord-288670-1vlowf2n	61	5	Vero	Vero	NNP
cord-288670-1vlowf2n	61	6	cells	cell	NNS
cord-288670-1vlowf2n	61	7	infected	infect	VBN
cord-288670-1vlowf2n	61	8	with	with	IN
cord-288670-1vlowf2n	61	9	SARS	SARS	NNP
cord-288670-1vlowf2n	61	10	-	-	HYPH
cord-288670-1vlowf2n	61	11	CoVs	CoVs	NNP
cord-288670-1vlowf2n	61	12	,	,	,
cord-288670-1vlowf2n	61	13	Snijder	Snijder	NNP
cord-288670-1vlowf2n	61	14	et	et	NNP
cord-288670-1vlowf2n	61	15	al	al	NNP
cord-288670-1vlowf2n	61	16	failed	fail	VBD
cord-288670-1vlowf2n	61	17	to	to	TO
cord-288670-1vlowf2n	61	18	detect	detect	VB
cord-288670-1vlowf2n	61	19	colocalization	colocalization	NN
cord-288670-1vlowf2n	61	20	of	of	IN
cord-288670-1vlowf2n	61	21	LC3	lc3	JJ
cord-288670-1vlowf2n	61	22	or	or	CC
cord-288670-1vlowf2n	61	23	GFP	GFP	NNP
cord-288670-1vlowf2n	61	24	-	-	HYPH
cord-288670-1vlowf2n	61	25	LC3	LC3	NNP
cord-288670-1vlowf2n	61	26	with	with	IN
cord-288670-1vlowf2n	61	27	the	the	DT
cord-288670-1vlowf2n	61	28	viral	viral	JJ
cord-288670-1vlowf2n	61	29	replication	replication	NN
cord-288670-1vlowf2n	61	30	-	-	HYPH
cord-288670-1vlowf2n	61	31	transcription	transcription	NN
cord-288670-1vlowf2n	61	32	complexes	complex	NNS
cord-288670-1vlowf2n	61	33	of	of	IN
cord-288670-1vlowf2n	61	34	SARS	SARS	NNP
cord-288670-1vlowf2n	61	35	-	-	HYPH
cord-288670-1vlowf2n	61	36	CoV	CoV	NNP
cord-288670-1vlowf2n	61	37	examined	examine	VBD
cord-288670-1vlowf2n	61	38	using	use	VBG
cord-288670-1vlowf2n	61	39	immunofluorescence	immunofluorescence	NN
cord-288670-1vlowf2n	61	40	staining	stain	VBG
cord-288670-1vlowf2n	61	41	[	[	-LRB-
cord-288670-1vlowf2n	61	42	27	27	CD
cord-288670-1vlowf2n	61	43	]	]	-RRB-
cord-288670-1vlowf2n	61	44	.	.	.
cord-288670-1vlowf2n	62	1	Further	further	JJ
cord-288670-1vlowf2n	62	2	studies	study	NNS
cord-288670-1vlowf2n	62	3	also	also	RB
cord-288670-1vlowf2n	62	4	demonstrated	demonstrate	VBD
cord-288670-1vlowf2n	62	5	that	that	IN
cord-288670-1vlowf2n	62	6	either	either	CC
cord-288670-1vlowf2n	62	7	ATG5	ATG5	NNP
cord-288670-1vlowf2n	62	8	or	or	CC
cord-288670-1vlowf2n	62	9	ATG7	ATG7	NNP
cord-288670-1vlowf2n	62	10	,	,	,
cord-288670-1vlowf2n	62	11	two	two	CD
cord-288670-1vlowf2n	62	12	of	of	IN
cord-288670-1vlowf2n	62	13	the	the	DT
cord-288670-1vlowf2n	62	14	key	key	JJ
cord-288670-1vlowf2n	62	15	autophagy	autophagy	NN
cord-288670-1vlowf2n	62	16	proteins	protein	NNS
cord-288670-1vlowf2n	62	17	in	in	IN
cord-288670-1vlowf2n	62	18	control	control	NN
cord-288670-1vlowf2n	62	19	of	of	IN
cord-288670-1vlowf2n	62	20	autophagosome	autophagosome	JJ
cord-288670-1vlowf2n	62	21	biogenesis	biogenesis	NN
cord-288670-1vlowf2n	62	22	,	,	,
cord-288670-1vlowf2n	62	23	is	be	VBZ
cord-288670-1vlowf2n	62	24	not	not	RB
cord-288670-1vlowf2n	62	25	required	require	VBN
cord-288670-1vlowf2n	62	26	for	for	IN
cord-288670-1vlowf2n	62	27	viral	viral	JJ
cord-288670-1vlowf2n	62	28	replication	replication	NN
cord-288670-1vlowf2n	62	29	in	in	IN
cord-288670-1vlowf2n	62	30	cells	cell	NNS
cord-288670-1vlowf2n	62	31	infected	infect	VBN
cord-288670-1vlowf2n	62	32	by	by	IN
cord-288670-1vlowf2n	62	33	MHV	MHV	NNP
cord-288670-1vlowf2n	62	34	[	[	-LRB-
cord-288670-1vlowf2n	62	35	28	28	CD
cord-288670-1vlowf2n	62	36	,	,	,
cord-288670-1vlowf2n	62	37	29	29	CD
cord-288670-1vlowf2n	62	38	]	]	-RRB-
cord-288670-1vlowf2n	62	39	or	or	CC
cord-288670-1vlowf2n	62	40	by	by	IN
cord-288670-1vlowf2n	62	41	SARS	SARS	NNP
cord-288670-1vlowf2n	62	42	-	-	HYPH
cord-288670-1vlowf2n	62	43	CoVs	CoVs	NNP
cord-288670-1vlowf2n	62	44	[	[	-LRB-
cord-288670-1vlowf2n	62	45	30	30	CD
cord-288670-1vlowf2n	62	46	]	]	-RRB-
cord-288670-1vlowf2n	62	47	.	.	.
cord-288670-1vlowf2n	63	1	In	in	IN
cord-288670-1vlowf2n	63	2	those	those	DT
cord-288670-1vlowf2n	63	3	studies	study	NNS
cord-288670-1vlowf2n	63	4	,	,	,
cord-288670-1vlowf2n	63	5	cells	cell	NNS
cord-288670-1vlowf2n	63	6	with	with	IN
cord-288670-1vlowf2n	63	7	deletion	deletion	NN
cord-288670-1vlowf2n	63	8	of	of	IN
cord-288670-1vlowf2n	63	9	either	either	CC
cord-288670-1vlowf2n	63	10	ATG5	ATG5	NNP
cord-288670-1vlowf2n	63	11	or	or	CC
cord-288670-1vlowf2n	63	12	ATG7	ATG7	NNP
cord-288670-1vlowf2n	63	13	failed	fail	VBD
cord-288670-1vlowf2n	63	14	to	to	TO
cord-288670-1vlowf2n	63	15	impair	impair	VB
cord-288670-1vlowf2n	63	16	the	the	DT
cord-288670-1vlowf2n	63	17	viral	viral	JJ
cord-288670-1vlowf2n	63	18	replication	replication	NN
cord-288670-1vlowf2n	63	19	rate	rate	NN
cord-288670-1vlowf2n	63	20	.	.	.
cord-288670-1vlowf2n	64	1	Similarly	similarly	RB
cord-288670-1vlowf2n	64	2	,	,	,
cord-288670-1vlowf2n	64	3	virus	virus	NN
cord-288670-1vlowf2n	64	4	infection	infection	NN
cord-288670-1vlowf2n	64	5	was	be	VBD
cord-288670-1vlowf2n	64	6	not	not	RB
cord-288670-1vlowf2n	64	7	inhibited	inhibit	VBN
cord-288670-1vlowf2n	64	8	by	by	IN
cord-288670-1vlowf2n	64	9	the	the	DT
cord-288670-1vlowf2n	64	10	knockdown	knockdown	NN
cord-288670-1vlowf2n	64	11	of	of	IN
cord-288670-1vlowf2n	64	12	ATG5	ATG5	NNP
cord-288670-1vlowf2n	64	13	[	[	-LRB-
cord-288670-1vlowf2n	64	14	26	26	CD
cord-288670-1vlowf2n	64	15	]	]	-RRB-
cord-288670-1vlowf2n	64	16	.	.	.
cord-288670-1vlowf2n	65	1	Thus	thus	RB
cord-288670-1vlowf2n	65	2	,	,	,
cord-288670-1vlowf2n	65	3	all	all	PDT
cord-288670-1vlowf2n	65	4	these	these	DT
cord-288670-1vlowf2n	65	5	observations	observation	NNS
cord-288670-1vlowf2n	65	6	suggest	suggest	VBP
cord-288670-1vlowf2n	65	7	that	that	IN
cord-288670-1vlowf2n	65	8	the	the	DT
cord-288670-1vlowf2n	65	9	autophagy	autophagy	NN
cord-288670-1vlowf2n	65	10	machinery	machinery	NN
cord-288670-1vlowf2n	65	11	is	be	VBZ
cord-288670-1vlowf2n	65	12	not	not	RB
cord-288670-1vlowf2n	65	13	directly	directly	RB
cord-288670-1vlowf2n	65	14	implicated	implicate	VBN
cord-288670-1vlowf2n	65	15	in	in	IN
cord-288670-1vlowf2n	65	16	the	the	DT
cord-288670-1vlowf2n	65	17	viral	viral	JJ
cord-288670-1vlowf2n	65	18	replication	replication	NN
cord-288670-1vlowf2n	65	19	process	process	NN
cord-288670-1vlowf2n	65	20	.	.	.
cord-288670-1vlowf2n	66	1	Intriguingly	intriguingly	RB
cord-288670-1vlowf2n	66	2	,	,	,
cord-288670-1vlowf2n	66	3	there	there	EX
cord-288670-1vlowf2n	66	4	is	be	VBZ
cord-288670-1vlowf2n	66	5	evidence	evidence	NN
cord-288670-1vlowf2n	66	6	suggesting	suggest	VBG
cord-288670-1vlowf2n	66	7	the	the	DT
cord-288670-1vlowf2n	66	8	possible	possible	JJ
cord-288670-1vlowf2n	66	9	inhibitory	inhibitory	JJ
cord-288670-1vlowf2n	66	10	effect	effect	NN
cord-288670-1vlowf2n	66	11	of	of	IN
cord-288670-1vlowf2n	66	12	CoV	cov	NN
cord-288670-1vlowf2n	66	13	on	on	IN
cord-288670-1vlowf2n	66	14	the	the	DT
cord-288670-1vlowf2n	66	15	autophagy	autophagy	NN
cord-288670-1vlowf2n	66	16	process	process	NN
cord-288670-1vlowf2n	66	17	.	.	.
cord-288670-1vlowf2n	67	1	For	for	IN
cord-288670-1vlowf2n	67	2	instance	instance	NN
cord-288670-1vlowf2n	67	3	,	,	,
cord-288670-1vlowf2n	67	4	a	a	DT
cord-288670-1vlowf2n	67	5	study	study	NN
cord-288670-1vlowf2n	67	6	using	use	VBG
cord-288670-1vlowf2n	67	7	SARS	SARS	NNP
cord-288670-1vlowf2n	67	8	-	-	HYPH
cord-288670-1vlowf2n	67	9	CoV	CoV	NNP
cord-288670-1vlowf2n	67	10	and	and	CC
cord-288670-1vlowf2n	67	11	MERS	MERS	NNP
cord-288670-1vlowf2n	67	12	-	-	HYPH
cord-288670-1vlowf2n	67	13	CoV	CoV	NNP
cord-288670-1vlowf2n	67	14	in	in	IN
cord-288670-1vlowf2n	67	15	HEK293	HEK293	NNP
cord-288670-1vlowf2n	67	16	T	T	NNP
cord-288670-1vlowf2n	67	17	,	,	,
cord-288670-1vlowf2n	67	18	HeLa	HeLa	NNP
cord-288670-1vlowf2n	67	19	and	and	CC
cord-288670-1vlowf2n	67	20	MCF-7	MCF-7	NNP
cord-288670-1vlowf2n	67	21	cells	cell	NNS
cord-288670-1vlowf2n	67	22	found	find	VBD
cord-288670-1vlowf2n	67	23	that	that	IN
cord-288670-1vlowf2n	67	24	overexpression	overexpression	NN
cord-288670-1vlowf2n	67	25	of	of	IN
cord-288670-1vlowf2n	67	26	membrane	membrane	NN
cord-288670-1vlowf2n	67	27	-	-	HYPH
cord-288670-1vlowf2n	67	28	associated	associate	VBN
cord-288670-1vlowf2n	67	29	papainlike	papainlike	NN
cord-288670-1vlowf2n	67	30	protease	protease	NN
cord-288670-1vlowf2n	67	31	PLP2	PLP2	NNP
cord-288670-1vlowf2n	67	32	(	(	-LRB-
cord-288670-1vlowf2n	67	33	PLP2-TM	PLP2-TM	NNP
cord-288670-1vlowf2n	67	34	)	)	-RRB-
cord-288670-1vlowf2n	67	35	of	of	IN
cord-288670-1vlowf2n	67	36	SARS	SARS	NNP
cord-288670-1vlowf2n	67	37	-	-	HYPH
cord-288670-1vlowf2n	67	38	CoV	CoV	NNP
cord-288670-1vlowf2n	67	39	and	and	CC
cord-288670-1vlowf2n	67	40	MERS	MERS	NNP
cord-288670-1vlowf2n	67	41	-	-	HYPH
cord-288670-1vlowf2n	67	42	CoV	CoV	NNP
cord-288670-1vlowf2n	67	43	led	lead	VBD
cord-288670-1vlowf2n	67	44	to	to	IN
cord-288670-1vlowf2n	67	45	blockage	blockage	NN
cord-288670-1vlowf2n	67	46	of	of	IN
cord-288670-1vlowf2n	67	47	autophagosomeslysosomes	autophagosomeslysosomes	NNP
cord-288670-1vlowf2n	67	48	fusion	fusion	NN
cord-288670-1vlowf2n	67	49	and	and	CC
cord-288670-1vlowf2n	67	50	suppression	suppression	NN
cord-288670-1vlowf2n	67	51	of	of	IN
cord-288670-1vlowf2n	67	52	the	the	DT
cord-288670-1vlowf2n	67	53	autophagic	autophagic	NNP
cord-288670-1vlowf2n	67	54	flux	flux	NN
cord-288670-1vlowf2n	67	55	[	[	-LRB-
cord-288670-1vlowf2n	67	56	31	31	CD
cord-288670-1vlowf2n	67	57	]	]	-RRB-
cord-288670-1vlowf2n	67	58	.	.	.
cord-288670-1vlowf2n	68	1	Consistently	consistently	RB
cord-288670-1vlowf2n	68	2	,	,	,
cord-288670-1vlowf2n	68	3	a	a	DT
cord-288670-1vlowf2n	68	4	more	more	RBR
cord-288670-1vlowf2n	68	5	recent	recent	JJ
cord-288670-1vlowf2n	68	6	report	report	NN
cord-288670-1vlowf2n	68	7	found	find	VBD
cord-288670-1vlowf2n	68	8	that	that	IN
cord-288670-1vlowf2n	68	9	MERS	MERS	NNP
cord-288670-1vlowf2n	68	10	-	-	HYPH
cord-288670-1vlowf2n	68	11	CoV	CoV	NNP
cord-288670-1vlowf2n	68	12	blocks	block	VBZ
cord-288670-1vlowf2n	68	13	the	the	DT
cord-288670-1vlowf2n	68	14	fusion	fusion	NN
cord-288670-1vlowf2n	68	15	of	of	IN
cord-288670-1vlowf2n	68	16	autophagosomes	autophagosome	NNS
cord-288670-1vlowf2n	68	17	and	and	CC
cord-288670-1vlowf2n	68	18	lysosomes	lysosome	NNS
cord-288670-1vlowf2n	68	19	and	and	CC
cord-288670-1vlowf2n	68	20	induction	induction	NN
cord-288670-1vlowf2n	68	21	of	of	IN
cord-288670-1vlowf2n	68	22	autophagy	autophagy	NN
cord-288670-1vlowf2n	68	23	reduces	reduce	VBZ
cord-288670-1vlowf2n	68	24	the	the	DT
cord-288670-1vlowf2n	68	25	replication	replication	NN
cord-288670-1vlowf2n	68	26	of	of	IN
cord-288670-1vlowf2n	68	27	MERS	MERS	NNP
cord-288670-1vlowf2n	68	28	-	-	HYPH
cord-288670-1vlowf2n	68	29	CoV	CoV	NNP
cord-288670-1vlowf2n	68	30	[	[	-LRB-
cord-288670-1vlowf2n	68	31	32	32	CD
cord-288670-1vlowf2n	68	32	]	]	-RRB-
cord-288670-1vlowf2n	68	33	.	.	.
cord-288670-1vlowf2n	69	1	Thus	thus	RB
cord-288670-1vlowf2n	69	2	,	,	,
cord-288670-1vlowf2n	69	3	it	-PRON-	PRP
cord-288670-1vlowf2n	69	4	appears	appear	VBZ
cord-288670-1vlowf2n	69	5	that	that	IN
cord-288670-1vlowf2n	69	6	there	there	EX
cord-288670-1vlowf2n	69	7	is	be	VBZ
cord-288670-1vlowf2n	69	8	certain	certain	JJ
cord-288670-1vlowf2n	69	9	type	type	NN
cord-288670-1vlowf2n	69	10	of	of	IN
cord-288670-1vlowf2n	69	11	interplay	interplay	NN
cord-288670-1vlowf2n	69	12	between	between	IN
cord-288670-1vlowf2n	69	13	the	the	DT
cord-288670-1vlowf2n	69	14	autophagy	autophagy	NN
cord-288670-1vlowf2n	69	15	machinery	machinery	NN
cord-288670-1vlowf2n	69	16	and	and	CC
cord-288670-1vlowf2n	69	17	CoVs	CoVs	NNP
cord-288670-1vlowf2n	69	18	,	,	,
cord-288670-1vlowf2n	69	19	and	and	CC
cord-288670-1vlowf2n	69	20	the	the	DT
cord-288670-1vlowf2n	69	21	exact	exact	JJ
cord-288670-1vlowf2n	69	22	nature	nature	NN
cord-288670-1vlowf2n	69	23	of	of	IN
cord-288670-1vlowf2n	69	24	such	such	JJ
cord-288670-1vlowf2n	69	25	interaction	interaction	NN
cord-288670-1vlowf2n	69	26	remains	remain	VBZ
cord-288670-1vlowf2n	69	27	to	to	TO
cord-288670-1vlowf2n	69	28	be	be	VB
cord-288670-1vlowf2n	69	29	further	further	RB
cord-288670-1vlowf2n	69	30	elucidated	elucidate	VBN
cord-288670-1vlowf2n	69	31	.	.	.
cord-288670-1vlowf2n	70	1	Taken	take	VBN
cord-288670-1vlowf2n	70	2	together	together	RB
cord-288670-1vlowf2n	70	3	,	,	,
cord-288670-1vlowf2n	70	4	as	as	IN
cord-288670-1vlowf2n	70	5	summarized	summarize	VBN
cord-288670-1vlowf2n	70	6	in	in	IN
cord-288670-1vlowf2n	70	7	Table	Table	NNP
cord-288670-1vlowf2n	70	8	1	1	CD
cord-288670-1vlowf2n	70	9	,	,	,
cord-288670-1vlowf2n	70	10	it	-PRON-	PRP
cord-288670-1vlowf2n	70	11	is	be	VBZ
cord-288670-1vlowf2n	70	12	still	still	RB
cord-288670-1vlowf2n	70	13	controversial	controversial	JJ
cord-288670-1vlowf2n	71	1	whether	whether	IN
cord-288670-1vlowf2n	71	2	and	and	CC
cord-288670-1vlowf2n	71	3	how	how	WRB
cord-288670-1vlowf2n	71	4	autophagy	autophagy	NN
cord-288670-1vlowf2n	71	5	is	be	VBZ
cord-288670-1vlowf2n	71	6	implicated	implicate	VBN
cord-288670-1vlowf2n	71	7	in	in	IN
cord-288670-1vlowf2n	71	8	the	the	DT
cord-288670-1vlowf2n	71	9	infection	infection	NN
cord-288670-1vlowf2n	71	10	of	of	IN
cord-288670-1vlowf2n	71	11	CoVs	CoVs	NNP
cord-288670-1vlowf2n	71	12	.	.	.
cord-288670-1vlowf2n	72	1	The	the	DT
cord-288670-1vlowf2n	72	2	discrepancies	discrepancy	NNS
cord-288670-1vlowf2n	72	3	in	in	IN
cord-288670-1vlowf2n	72	4	the	the	DT
cord-288670-1vlowf2n	72	5	literature	literature	NN
cord-288670-1vlowf2n	72	6	is	be	VBZ
cord-288670-1vlowf2n	72	7	probably	probably	RB
cord-288670-1vlowf2n	72	8	due	due	JJ
cord-288670-1vlowf2n	72	9	to	to	IN
cord-288670-1vlowf2n	72	10	the	the	DT
cord-288670-1vlowf2n	72	11	different	different	JJ
cord-288670-1vlowf2n	72	12	viruses	virus	NNS
cord-288670-1vlowf2n	72	13	used	use	VBN
cord-288670-1vlowf2n	72	14	,	,	,
cord-288670-1vlowf2n	72	15	different	different	JJ
cord-288670-1vlowf2n	72	16	cells	cell	NNS
cord-288670-1vlowf2n	72	17	tested	test	VBN
cord-288670-1vlowf2n	72	18	and	and	CC
cord-288670-1vlowf2n	72	19	even	even	RB
cord-288670-1vlowf2n	72	20	the	the	DT
cord-288670-1vlowf2n	72	21	different	different	JJ
cord-288670-1vlowf2n	72	22	techniques	technique	NNS
cord-288670-1vlowf2n	72	23	used	use	VBN
cord-288670-1vlowf2n	72	24	in	in	IN
cord-288670-1vlowf2n	72	25	study	study	NN
cord-288670-1vlowf2n	72	26	of	of	IN
cord-288670-1vlowf2n	72	27	autophagy	autophagy	NN
cord-288670-1vlowf2n	72	28	.	.	.
cord-288670-1vlowf2n	73	1	More	More	JJR
cord-288670-1vlowf2n	73	2	work	work	NN
cord-288670-1vlowf2n	73	3	is	be	VBZ
cord-288670-1vlowf2n	73	4	thus	thus	RB
cord-288670-1vlowf2n	73	5	needed	need	VBN
cord-288670-1vlowf2n	73	6	to	to	TO
cord-288670-1vlowf2n	73	7	clarify	clarify	VB
cord-288670-1vlowf2n	73	8	those	those	DT
cord-288670-1vlowf2n	73	9	important	important	JJ
cord-288670-1vlowf2n	73	10	issues	issue	NNS
cord-288670-1vlowf2n	73	11	.	.	.
cord-288670-1vlowf2n	73	12	 	 	_SP
cord-288670-1vlowf2n	74	1	One	one	CD
cord-288670-1vlowf2n	74	2	of	of	IN
cord-288670-1vlowf2n	74	3	the	the	DT
cord-288670-1vlowf2n	74	4	key	key	JJ
cord-288670-1vlowf2n	74	5	determining	determine	VBG
cord-288670-1vlowf2n	74	6	factors	factor	NNS
cord-288670-1vlowf2n	74	7	in	in	IN
cord-288670-1vlowf2n	74	8	viral	viral	JJ
cord-288670-1vlowf2n	74	9	infection	infection	NN
cord-288670-1vlowf2n	74	10	is	be	VBZ
cord-288670-1vlowf2n	74	11	the	the	DT
cord-288670-1vlowf2n	74	12	entry	entry	NN
cord-288670-1vlowf2n	74	13	of	of	IN
cord-288670-1vlowf2n	74	14	the	the	DT
cord-288670-1vlowf2n	74	15	virus	virus	NN
cord-288670-1vlowf2n	74	16	into	into	IN
cord-288670-1vlowf2n	74	17	the	the	DT
cord-288670-1vlowf2n	74	18	host	host	NN
cord-288670-1vlowf2n	74	19	cells	cell	NNS
cord-288670-1vlowf2n	74	20	.	.	.
cord-288670-1vlowf2n	75	1	At	at	IN
cord-288670-1vlowf2n	75	2	present	present	NN
cord-288670-1vlowf2n	75	3	,	,	,
cord-288670-1vlowf2n	75	4	it	-PRON-	PRP
cord-288670-1vlowf2n	75	5	is	be	VBZ
cord-288670-1vlowf2n	75	6	widely	widely	RB
cord-288670-1vlowf2n	75	7	believed	believe	VBN
cord-288670-1vlowf2n	75	8	that	that	IN
cord-288670-1vlowf2n	75	9	CoVs	CoVs	NNP
cord-288670-1vlowf2n	75	10	enter	enter	VB
cord-288670-1vlowf2n	75	11	the	the	DT
cord-288670-1vlowf2n	75	12	host	host	NN
cord-288670-1vlowf2n	75	13	cells	cell	NNS
cord-288670-1vlowf2n	75	14	via	via	IN
cord-288670-1vlowf2n	75	15	two	two	CD
cord-288670-1vlowf2n	75	16	routes	route	NNS
cord-288670-1vlowf2n	75	17	:	:	:
cord-288670-1vlowf2n	76	1	(	(	-LRB-
cord-288670-1vlowf2n	76	2	i	i	NN
cord-288670-1vlowf2n	76	3	)	)	-RRB-
cord-288670-1vlowf2n	77	1	the	the	DT
cord-288670-1vlowf2n	77	2	endocytic	endocytic	JJ
cord-288670-1vlowf2n	77	3	pathway	pathway	NN
cord-288670-1vlowf2n	77	4	and	and	CC
cord-288670-1vlowf2n	77	5	(	(	-LRB-
cord-288670-1vlowf2n	77	6	ii	ii	NN
cord-288670-1vlowf2n	77	7	)	)	-RRB-
cord-288670-1vlowf2n	77	8	non	non	JJ
cord-288670-1vlowf2n	77	9	-	-	JJ
cord-288670-1vlowf2n	77	10	endosomal	endosomal	JJ
cord-288670-1vlowf2n	77	11	pathway	pathway	NN
cord-288670-1vlowf2n	77	12	[	[	-LRB-
cord-288670-1vlowf2n	77	13	33	33	CD
cord-288670-1vlowf2n	77	14	]	]	-RRB-
cord-288670-1vlowf2n	77	15	,	,	,
cord-288670-1vlowf2n	77	16	as	as	IN
cord-288670-1vlowf2n	77	17	partly	partly	RB
cord-288670-1vlowf2n	77	18	illustrated	illustrate	VBN
cord-288670-1vlowf2n	77	19	in	in	IN
cord-288670-1vlowf2n	77	20	Figure	Figure	NNP
cord-288670-1vlowf2n	77	21	1	1	CD
cord-288670-1vlowf2n	77	22	.	.	.
cord-288670-1vlowf2n	78	1	Among	among	IN
cord-288670-1vlowf2n	78	2	them	-PRON-	PRP
cord-288670-1vlowf2n	78	3	,	,	,
cord-288670-1vlowf2n	78	4	the	the	DT
cord-288670-1vlowf2n	78	5	endocytic	endocytic	JJ
cord-288670-1vlowf2n	78	6	pathway	pathway	NN
cord-288670-1vlowf2n	78	7	is	be	VBZ
cord-288670-1vlowf2n	78	8	considered	consider	VBN
cord-288670-1vlowf2n	78	9	to	to	TO
cord-288670-1vlowf2n	78	10	be	be	VB
cord-288670-1vlowf2n	78	11	particularly	particularly	RB
cord-288670-1vlowf2n	78	12	important	important	JJ
cord-288670-1vlowf2n	78	13	and	and	CC
cord-288670-1vlowf2n	78	14	has	have	VBZ
cord-288670-1vlowf2n	78	15	been	be	VBN
cord-288670-1vlowf2n	78	16	extensively	extensively	RB
cord-288670-1vlowf2n	78	17	studied	study	VBN
cord-288670-1vlowf2n	78	18	.	.	.
cord-288670-1vlowf2n	79	1	As	as	IN
cord-288670-1vlowf2n	79	2	discussed	discuss	VBN
cord-288670-1vlowf2n	79	3	earlier	early	RBR
cord-288670-1vlowf2n	79	4	,	,	,
cord-288670-1vlowf2n	79	5	CoVs	CoVs	NNP
cord-288670-1vlowf2n	79	6	are	be	VBP
cord-288670-1vlowf2n	79	7	enveloped	envelop	VBN
cord-288670-1vlowf2n	79	8	and	and	CC
cord-288670-1vlowf2n	79	9	plus	plus	JJ
cord-288670-1vlowf2n	79	10	-	-	HYPH
cord-288670-1vlowf2n	79	11	strand	strand	NN
cord-288670-1vlowf2n	79	12	RNA	RNA	NNP
cord-288670-1vlowf2n	79	13	virus	virus	NN
cord-288670-1vlowf2n	79	14	and	and	CC
cord-288670-1vlowf2n	79	15	they	-PRON-	PRP
cord-288670-1vlowf2n	79	16	contain	contain	VBP
cord-288670-1vlowf2n	79	17	a	a	DT
cord-288670-1vlowf2n	79	18	set	set	NN
cord-288670-1vlowf2n	79	19	of	of	IN
cord-288670-1vlowf2n	79	20	four	four	CD
cord-288670-1vlowf2n	79	21	proteins	protein	NNS
cord-288670-1vlowf2n	79	22	that	that	WDT
cord-288670-1vlowf2n	79	23	encapsidate	encapsidate	VBP
cord-288670-1vlowf2n	79	24	the	the	DT
cord-288670-1vlowf2n	79	25	viral	viral	JJ
cord-288670-1vlowf2n	79	26	genomic	genomic	JJ
cord-288670-1vlowf2n	79	27	RNA	RNA	NNP
cord-288670-1vlowf2n	79	28	:	:	:
cord-288670-1vlowf2n	79	29	the	the	DT
cord-288670-1vlowf2n	79	30	nucleocapsid	nucleocapsid	NNP
cord-288670-1vlowf2n	79	31	protein	protein	NNP
cord-288670-1vlowf2n	79	32	(	(	-LRB-
cord-288670-1vlowf2n	79	33	N	N	NNP
cord-288670-1vlowf2n	79	34	)	)	-RRB-
cord-288670-1vlowf2n	79	35	,	,	,
cord-288670-1vlowf2n	79	36	the	the	DT
cord-288670-1vlowf2n	79	37	membrane	membrane	NN
cord-288670-1vlowf2n	79	38	glycoprotein	glycoprotein	NN
cord-288670-1vlowf2n	79	39	(	(	-LRB-
cord-288670-1vlowf2n	79	40	M	M	NNP
cord-288670-1vlowf2n	79	41	)	)	-RRB-
cord-288670-1vlowf2n	79	42	,	,	,
cord-288670-1vlowf2n	79	43	the	the	DT
cord-288670-1vlowf2n	79	44	envelope	envelope	NN
cord-288670-1vlowf2n	79	45	protein	protein	NN
cord-288670-1vlowf2n	79	46	(	(	-LRB-
cord-288670-1vlowf2n	79	47	E	E	NNP
cord-288670-1vlowf2n	79	48	)	)	-RRB-
cord-288670-1vlowf2n	79	49	,	,	,
cord-288670-1vlowf2n	79	50	and	and	CC
cord-288670-1vlowf2n	79	51	the	the	DT
cord-288670-1vlowf2n	79	52	spike	spike	NN
cord-288670-1vlowf2n	79	53	glycoprotein	glycoprotein	NN
cord-288670-1vlowf2n	79	54	(	(	-LRB-
cord-288670-1vlowf2n	79	55	S	s	NN
cord-288670-1vlowf2n	79	56	)	)	-RRB-
cord-288670-1vlowf2n	79	57	[	[	-LRB-
cord-288670-1vlowf2n	79	58	34	34	CD
cord-288670-1vlowf2n	79	59	]	]	-RRB-
cord-288670-1vlowf2n	79	60	.	.	.
cord-288670-1vlowf2n	80	1	Among	among	IN
cord-288670-1vlowf2n	80	2	them	-PRON-	PRP
cord-288670-1vlowf2n	80	3	,	,	,
cord-288670-1vlowf2n	80	4	the	the	DT
cord-288670-1vlowf2n	80	5	function	function	NN
cord-288670-1vlowf2n	80	6	of	of	IN
cord-288670-1vlowf2n	80	7	the	the	DT
cord-288670-1vlowf2n	80	8	S	S	NNP
cord-288670-1vlowf2n	80	9	protein	protein	NN
cord-288670-1vlowf2n	80	10	is	be	VBZ
cord-288670-1vlowf2n	80	11	mainly	mainly	RB
cord-288670-1vlowf2n	80	12	involved	involve	VBN
cord-288670-1vlowf2n	80	13	in	in	IN
cord-288670-1vlowf2n	80	14	the	the	DT
cord-288670-1vlowf2n	80	15	process	process	NN
cord-288670-1vlowf2n	80	16	of	of	IN
cord-288670-1vlowf2n	80	17	viral	viral	JJ
cord-288670-1vlowf2n	80	18	entry	entry	NN
cord-288670-1vlowf2n	80	19	into	into	IN
cord-288670-1vlowf2n	80	20	the	the	DT
cord-288670-1vlowf2n	80	21	host	host	NN
cord-288670-1vlowf2n	80	22	cells	cell	NNS
cord-288670-1vlowf2n	80	23	via	via	IN
cord-288670-1vlowf2n	80	24	proteolytic	proteolytic	JJ
cord-288670-1vlowf2n	80	25	cleavage	cleavage	NN
cord-288670-1vlowf2n	80	26	to	to	TO
cord-288670-1vlowf2n	80	27	form	form	VB
cord-288670-1vlowf2n	80	28	two	two	CD
cord-288670-1vlowf2n	80	29	subunits	subunit	NNS
cord-288670-1vlowf2n	80	30	,	,	,
cord-288670-1vlowf2n	80	31	S1	s1	NN
cord-288670-1vlowf2n	80	32	and	and	CC
cord-288670-1vlowf2n	80	33	S2	S2	NNP
cord-288670-1vlowf2n	80	34	[	[	-LRB-
cord-288670-1vlowf2n	80	35	35	35	CD
cord-288670-1vlowf2n	80	36	]	]	-RRB-
cord-288670-1vlowf2n	80	37	.	.	.
cord-288670-1vlowf2n	81	1	These	these	DT
cord-288670-1vlowf2n	81	2	two	two	CD
cord-288670-1vlowf2n	81	3	subunits	subunit	NNS
cord-288670-1vlowf2n	81	4	have	have	VBP
cord-288670-1vlowf2n	81	5	distinct	distinct	JJ
cord-288670-1vlowf2n	81	6	functions	function	NNS
cord-288670-1vlowf2n	81	7	:	:	:
cord-288670-1vlowf2n	81	8	S1	s1	NN
cord-288670-1vlowf2n	81	9	is	be	VBZ
cord-288670-1vlowf2n	81	10	responsible	responsible	JJ
cord-288670-1vlowf2n	81	11	for	for	IN
cord-288670-1vlowf2n	81	12	receptor	receptor	NN
cord-288670-1vlowf2n	81	13	-	-	HYPH
cord-288670-1vlowf2n	81	14	binding	binding	NN
cord-288670-1vlowf2n	81	15	,	,	,
cord-288670-1vlowf2n	81	16	while	while	IN
cord-288670-1vlowf2n	81	17	S2	S2	NNP
cord-288670-1vlowf2n	81	18	is	be	VBZ
cord-288670-1vlowf2n	81	19	mainly	mainly	RB
cord-288670-1vlowf2n	81	20	for	for	IN
cord-288670-1vlowf2n	81	21	membrane	membrane	NN
cord-288670-1vlowf2n	81	22	fusion	fusion	NN
cord-288670-1vlowf2n	81	23	and	and	CC
cord-288670-1vlowf2n	81	24	both	both	DT
cord-288670-1vlowf2n	81	25	are	be	VBP
cord-288670-1vlowf2n	81	26	essential	essential	JJ
cord-288670-1vlowf2n	81	27	for	for	IN
cord-288670-1vlowf2n	81	28	viral	viral	JJ
cord-288670-1vlowf2n	81	29	entry	entry	NN
cord-288670-1vlowf2n	81	30	via	via	IN
cord-288670-1vlowf2n	81	31	the	the	DT
cord-288670-1vlowf2n	81	32	endocytic	endocytic	JJ
cord-288670-1vlowf2n	81	33	pathway	pathway	NN
cord-288670-1vlowf2n	81	34	and	and	CC
cord-288670-1vlowf2n	81	35	infection	infection	NN
cord-288670-1vlowf2n	81	36	into	into	IN
cord-288670-1vlowf2n	81	37	the	the	DT
cord-288670-1vlowf2n	81	38	host	host	NN
cord-288670-1vlowf2n	81	39	cells	cell	NNS
cord-288670-1vlowf2n	81	40	.	.	.
cord-288670-1vlowf2n	82	1	The	the	DT
cord-288670-1vlowf2n	82	2	first	first	JJ
cord-288670-1vlowf2n	82	3	report	report	NN
cord-288670-1vlowf2n	82	4	showing	show	VBG
cord-288670-1vlowf2n	82	5	the	the	DT
cord-288670-1vlowf2n	82	6	relevance	relevance	NN
cord-288670-1vlowf2n	82	7	of	of	IN
cord-288670-1vlowf2n	82	8	endosome	endosome	NN
cord-288670-1vlowf2n	82	9	-	-	HYPH
cord-288670-1vlowf2n	82	10	lysosome	lysosome	NN
cord-288670-1vlowf2n	82	11	in	in	IN
cord-288670-1vlowf2n	82	12	CoVs	CoVs	NNP
cord-288670-1vlowf2n	82	13	was	be	VBD
cord-288670-1vlowf2n	82	14	from	from	IN
cord-288670-1vlowf2n	82	15	a	a	DT
cord-288670-1vlowf2n	82	16	morphological	morphological	JJ
cord-288670-1vlowf2n	82	17	study	study	NN
cord-288670-1vlowf2n	82	18	in	in	IN
cord-288670-1vlowf2n	82	19	which	which	WDT
cord-288670-1vlowf2n	82	20	two	two	CD
cord-288670-1vlowf2n	82	21	CoVs	CoVs	NNP
cord-288670-1vlowf2n	82	22	(	(	-LRB-
cord-288670-1vlowf2n	82	23	IBV	IBV	NNP
cord-288670-1vlowf2n	82	24	and	and	CC
cord-288670-1vlowf2n	82	25	Porcine	Porcine	NNP
cord-288670-1vlowf2n	82	26	Epidemic	Epidemic	NNP
cord-288670-1vlowf2n	82	27	Diarrhea	diarrhea	NN
cord-288670-1vlowf2n	82	28	Virus	virus	NN
cord-288670-1vlowf2n	82	29	(	(	-LRB-
cord-288670-1vlowf2n	82	30	PEDV	PEDV	NNP
cord-288670-1vlowf2n	82	31	)	)	-RRB-
cord-288670-1vlowf2n	82	32	)	)	-RRB-
cord-288670-1vlowf2n	82	33	were	be	VBD
cord-288670-1vlowf2n	82	34	found	find	VBN
cord-288670-1vlowf2n	82	35	to	to	TO
cord-288670-1vlowf2n	82	36	accumulate	accumulate	VB
cord-288670-1vlowf2n	82	37	in	in	IN
cord-288670-1vlowf2n	82	38	the	the	DT
cord-288670-1vlowf2n	82	39	lysosomes	lysosome	NNS
cord-288670-1vlowf2n	82	40	of	of	IN
cord-288670-1vlowf2n	82	41	cells	cell	NNS
cord-288670-1vlowf2n	82	42	after	after	IN
cord-288670-1vlowf2n	82	43	infection	infection	NN
cord-288670-1vlowf2n	82	44	[	[	-LRB-
cord-288670-1vlowf2n	82	45	36	36	CD
cord-288670-1vlowf2n	82	46	]	]	-RRB-
cord-288670-1vlowf2n	82	47	,	,	,
cord-288670-1vlowf2n	82	48	indicating	indicate	VBG
cord-288670-1vlowf2n	82	49	that	that	IN
cord-288670-1vlowf2n	82	50	the	the	DT
cord-288670-1vlowf2n	82	51	possible	possible	JJ
cord-288670-1vlowf2n	82	52	functional	functional	JJ
cord-288670-1vlowf2n	82	53	implication	implication	NN
cord-288670-1vlowf2n	82	54	of	of	IN
cord-288670-1vlowf2n	82	55	lysosome	lysosome	NN
cord-288670-1vlowf2n	82	56	in	in	IN
cord-288670-1vlowf2n	82	57	CoVs	CoVs	NNP
cord-288670-1vlowf2n	82	58	infection	infection	NN
cord-288670-1vlowf2n	82	59	.	.	.
cord-288670-1vlowf2n	83	1	Subsequent	subsequent	JJ
cord-288670-1vlowf2n	83	2	studies	study	NNS
cord-288670-1vlowf2n	83	3	have	have	VBP
cord-288670-1vlowf2n	83	4	firmly	firmly	RB
cord-288670-1vlowf2n	83	5	established	establish	VBN
cord-288670-1vlowf2n	83	6	that	that	IN
cord-288670-1vlowf2n	83	7	the	the	DT
cord-288670-1vlowf2n	83	8	endocytic	endocytic	JJ
cord-288670-1vlowf2n	83	9	pathway	pathway	NN
cord-288670-1vlowf2n	83	10	is	be	VBZ
cord-288670-1vlowf2n	83	11	the	the	DT
cord-288670-1vlowf2n	83	12	key	key	JJ
cord-288670-1vlowf2n	83	13	mechanisms	mechanism	NNS
cord-288670-1vlowf2n	83	14	controlling	control	VBG
cord-288670-1vlowf2n	83	15	the	the	DT
cord-288670-1vlowf2n	83	16	entry	entry	NN
cord-288670-1vlowf2n	83	17	of	of	IN
cord-288670-1vlowf2n	83	18	CoVs	CoVs	NNP
cord-288670-1vlowf2n	83	19	into	into	IN
cord-288670-1vlowf2n	83	20	the	the	DT
cord-288670-1vlowf2n	83	21	host	host	NN
cord-288670-1vlowf2n	83	22	cells	cell	NNS
cord-288670-1vlowf2n	83	23	,	,	,
cord-288670-1vlowf2n	83	24	and	and	CC
cord-288670-1vlowf2n	83	25	thus	thus	RB
cord-288670-1vlowf2n	83	26	the	the	DT
cord-288670-1vlowf2n	83	27	endocytic	endocytic	JJ
cord-288670-1vlowf2n	83	28	pathway	pathway	NN
cord-288670-1vlowf2n	83	29	has	have	VBZ
cord-288670-1vlowf2n	83	30	been	be	VBN
cord-288670-1vlowf2n	83	31	widely	widely	RB
cord-288670-1vlowf2n	83	32	investigated	investigate	VBN
cord-288670-1vlowf2n	83	33	as	as	IN
cord-288670-1vlowf2n	83	34	the	the	DT
cord-288670-1vlowf2n	83	35	target	target	NN
cord-288670-1vlowf2n	83	36	of	of	IN
cord-288670-1vlowf2n	83	37	anti	anti	JJ
cord-288670-1vlowf2n	83	38	-	-	JJ
cord-288670-1vlowf2n	83	39	viral	viral	JJ
cord-288670-1vlowf2n	83	40	therapies	therapy	NNS
cord-288670-1vlowf2n	83	41	,	,	,
cord-288670-1vlowf2n	83	42	as	as	IN
cord-288670-1vlowf2n	83	43	summarized	summarize	VBN
cord-288670-1vlowf2n	83	44	in	in	IN
cord-288670-1vlowf2n	83	45	Table	Table	NNP
cord-288670-1vlowf2n	83	46	2	2	CD
cord-288670-1vlowf2n	83	47	.	.	.
cord-288670-1vlowf2n	84	1	Among	among	IN
cord-288670-1vlowf2n	84	2	all	all	PDT
cord-288670-1vlowf2n	84	3	these	these	DT
cord-288670-1vlowf2n	84	4	studies	study	NNS
cord-288670-1vlowf2n	84	5	,	,	,
cord-288670-1vlowf2n	84	6	there	there	EX
cord-288670-1vlowf2n	84	7	are	be	VBP
cord-288670-1vlowf2n	84	8	several	several	JJ
cord-288670-1vlowf2n	84	9	important	important	JJ
cord-288670-1vlowf2n	84	10	points	point	NNS
cord-288670-1vlowf2n	84	11	to	to	TO
cord-288670-1vlowf2n	84	12	be	be	VB
cord-288670-1vlowf2n	84	13	highlighted	highlight	VBN
cord-288670-1vlowf2n	84	14	.	.	.
cord-288670-1vlowf2n	85	1	First	first	RB
cord-288670-1vlowf2n	85	2	,	,	,
cord-288670-1vlowf2n	85	3	different	different	JJ
cord-288670-1vlowf2n	85	4	CoVs	covs	NN
cord-288670-1vlowf2n	85	5	including	include	VBG
cord-288670-1vlowf2n	85	6	MHV	MHV	NNP
cord-288670-1vlowf2n	85	7	,	,	,
cord-288670-1vlowf2n	85	8	SARS	SARS	NNP
cord-288670-1vlowf2n	85	9	-	-	HYPH
cord-288670-1vlowf2n	85	10	CoV	CoV	NNP
cord-288670-1vlowf2n	85	11	and	and	CC
cord-288670-1vlowf2n	85	12	MERS	MERS	NNP
cord-288670-1vlowf2n	85	13	-	-	HYPH
cord-288670-1vlowf2n	85	14	CoV	CoV	NNP
cord-288670-1vlowf2n	85	15	have	have	VBP
cord-288670-1vlowf2n	85	16	been	be	VBN
cord-288670-1vlowf2n	85	17	consistently	consistently	RB
cord-288670-1vlowf2n	85	18	demonstrated	demonstrate	VBN
cord-288670-1vlowf2n	85	19	to	to	TO
cord-288670-1vlowf2n	85	20	engage	engage	VB
cord-288670-1vlowf2n	85	21	the	the	DT
cord-288670-1vlowf2n	85	22	endocytic	endocytic	JJ
cord-288670-1vlowf2n	85	23	pathway	pathway	NN
cord-288670-1vlowf2n	85	24	as	as	IN
cord-288670-1vlowf2n	85	25	the	the	DT
cord-288670-1vlowf2n	85	26	main	main	JJ
cord-288670-1vlowf2n	85	27	mechanism	mechanism	NN
cord-288670-1vlowf2n	85	28	for	for	IN
cord-288670-1vlowf2n	85	29	viral	viral	JJ
cord-288670-1vlowf2n	85	30	entry	entry	NN
cord-288670-1vlowf2n	85	31	into	into	IN
cord-288670-1vlowf2n	85	32	a	a	DT
cord-288670-1vlowf2n	85	33	variety	variety	NN
cord-288670-1vlowf2n	85	34	types	type	NNS
cord-288670-1vlowf2n	85	35	of	of	IN
cord-288670-1vlowf2n	85	36	host	host	NN
cord-288670-1vlowf2n	85	37	cells	cell	NNS
cord-288670-1vlowf2n	85	38	.	.	.
cord-288670-1vlowf2n	86	1	Among	among	IN
cord-288670-1vlowf2n	86	2	them	-PRON-	PRP
cord-288670-1vlowf2n	86	3	,	,	,
cord-288670-1vlowf2n	86	4	clathrin	clathrin	NN
cord-288670-1vlowf2n	86	5	-	-	HYPH
cord-288670-1vlowf2n	86	6	dependent	dependent	JJ
cord-288670-1vlowf2n	86	7	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	86	8	and	and	CC
cord-288670-1vlowf2n	86	9	cathepsinmediated	cathepsinmediated	NNP
cord-288670-1vlowf2n	86	10	S	S	NNP
cord-288670-1vlowf2n	86	11	protein	protein	NN
cord-288670-1vlowf2n	86	12	cleavage	cleavage	NN
cord-288670-1vlowf2n	86	13	are	be	VBP
cord-288670-1vlowf2n	86	14	two	two	CD
cord-288670-1vlowf2n	86	15	critical	critical	JJ
cord-288670-1vlowf2n	86	16	steps	step	NNS
cord-288670-1vlowf2n	86	17	for	for	IN
cord-288670-1vlowf2n	86	18	the	the	DT
cord-288670-1vlowf2n	86	19	viral	viral	JJ
cord-288670-1vlowf2n	86	20	entry	entry	NN
cord-288670-1vlowf2n	86	21	and	and	CC
cord-288670-1vlowf2n	86	22	infection	infection	NN
cord-288670-1vlowf2n	86	23	.	.	.
cord-288670-1vlowf2n	87	1	In	in	IN
cord-288670-1vlowf2n	87	2	fact	fact	NN
cord-288670-1vlowf2n	87	3	,	,	,
cord-288670-1vlowf2n	87	4	this	this	DT
cord-288670-1vlowf2n	87	5	mechanism	mechanism	NN
cord-288670-1vlowf2n	87	6	is	be	VBZ
cord-288670-1vlowf2n	87	7	also	also	RB
cord-288670-1vlowf2n	87	8	applicable	applicable	JJ
cord-288670-1vlowf2n	87	9	to	to	IN
cord-288670-1vlowf2n	87	10	many	many	JJ
cord-288670-1vlowf2n	87	11	other	other	JJ
cord-288670-1vlowf2n	87	12	CoVs	CoVs	NNP
cord-288670-1vlowf2n	87	13	such	such	JJ
cord-288670-1vlowf2n	87	14	as	as	IN
cord-288670-1vlowf2n	87	15	IBV	IBV	NNP
cord-288670-1vlowf2n	87	16	[	[	-LRB-
cord-288670-1vlowf2n	87	17	37	37	CD
cord-288670-1vlowf2n	87	18	]	]	-RRB-
cord-288670-1vlowf2n	87	19	,	,	,
cord-288670-1vlowf2n	87	20	which	which	WDT
cord-288670-1vlowf2n	87	21	is	be	VBZ
cord-288670-1vlowf2n	87	22	out	out	IN
cord-288670-1vlowf2n	87	23	of	of	IN
cord-288670-1vlowf2n	87	24	the	the	DT
cord-288670-1vlowf2n	87	25	scope	scope	NN
cord-288670-1vlowf2n	87	26	of	of	IN
cord-288670-1vlowf2n	87	27	this	this	DT
cord-288670-1vlowf2n	87	28	review	review	NN
cord-288670-1vlowf2n	87	29	.	.	.
cord-288670-1vlowf2n	88	1	Second	second	RB
cord-288670-1vlowf2n	88	2	,	,	,
cord-288670-1vlowf2n	88	3	despite	despite	IN
cord-288670-1vlowf2n	88	4	the	the	DT
cord-288670-1vlowf2n	88	5	general	general	JJ
cord-288670-1vlowf2n	88	6	understanding	understanding	NN
cord-288670-1vlowf2n	88	7	for	for	IN
cord-288670-1vlowf2n	88	8	the	the	DT
cord-288670-1vlowf2n	88	9	role	role	NN
cord-288670-1vlowf2n	88	10	of	of	IN
cord-288670-1vlowf2n	88	11	the	the	DT
cord-288670-1vlowf2n	88	12	endocytic	endocytic	JJ
cord-288670-1vlowf2n	88	13	pathway	pathway	NN
cord-288670-1vlowf2n	88	14	for	for	IN
cord-288670-1vlowf2n	88	15	viral	viral	JJ
cord-288670-1vlowf2n	88	16	entry	entry	NN
cord-288670-1vlowf2n	88	17	,	,	,
cord-288670-1vlowf2n	88	18	there	there	EX
cord-288670-1vlowf2n	88	19	are	be	VBP
cord-288670-1vlowf2n	88	20	discrepancies	discrepancy	NNS
cord-288670-1vlowf2n	88	21	of	of	IN
cord-288670-1vlowf2n	88	22	the	the	DT
cord-288670-1vlowf2n	88	23	exact	exact	JJ
cord-288670-1vlowf2n	88	24	mechanisms	mechanism	NNS
cord-288670-1vlowf2n	88	25	among	among	IN
cord-288670-1vlowf2n	88	26	different	different	JJ
cord-288670-1vlowf2n	88	27	reports	report	NNS
cord-288670-1vlowf2n	88	28	even	even	RB
cord-288670-1vlowf2n	88	29	with	with	IN
cord-288670-1vlowf2n	88	30	the	the	DT
cord-288670-1vlowf2n	88	31	same	same	JJ
cord-288670-1vlowf2n	88	32	CoV.	CoV.	NNP
cord-288670-1vlowf2n	89	1	For	for	IN
cord-288670-1vlowf2n	89	2	instance	instance	NN
cord-288670-1vlowf2n	89	3	,	,	,
cord-288670-1vlowf2n	89	4	Wang	Wang	NNP
cord-288670-1vlowf2n	89	5	et	et	NNP
cord-288670-1vlowf2n	89	6	al	al	NNP
cord-288670-1vlowf2n	89	7	found	find	VBD
cord-288670-1vlowf2n	89	8	that	that	IN
cord-288670-1vlowf2n	89	9	SARS	SARS	NNP
cord-288670-1vlowf2n	89	10	-	-	HYPH
cord-288670-1vlowf2n	89	11	CoVs	CoVs	NNP
cord-288670-1vlowf2n	89	12	engage	engage	VBP
cord-288670-1vlowf2n	89	13	clathrin	clathrin	NN
cord-288670-1vlowf2n	89	14	-	-	:
cord-288670-1vlowf2n	89	15	and	and	CC
cord-288670-1vlowf2n	89	16	caveolae	caveolae	JJ
cord-288670-1vlowf2n	89	17	-	-	HYPH
cord-288670-1vlowf2n	89	18	independent	independent	JJ
cord-288670-1vlowf2n	89	19	endocytic	endocytic	JJ
cord-288670-1vlowf2n	89	20	pathway	pathway	NN
cord-288670-1vlowf2n	89	21	as	as	IN
cord-288670-1vlowf2n	89	22	the	the	DT
cord-288670-1vlowf2n	89	23	key	key	JJ
cord-288670-1vlowf2n	89	24	mechanism	mechanism	NN
cord-288670-1vlowf2n	89	25	for	for	IN
cord-288670-1vlowf2n	89	26	viral	viral	JJ
cord-288670-1vlowf2n	89	27	entry	entry	NN
cord-288670-1vlowf2n	89	28	[	[	-LRB-
cord-288670-1vlowf2n	89	29	38	38	CD
cord-288670-1vlowf2n	89	30	]	]	-RRB-
cord-288670-1vlowf2n	89	31	,	,	,
cord-288670-1vlowf2n	89	32	which	which	WDT
cord-288670-1vlowf2n	89	33	is	be	VBZ
cord-288670-1vlowf2n	89	34	inconsistent	inconsistent	JJ
cord-288670-1vlowf2n	89	35	with	with	IN
cord-288670-1vlowf2n	89	36	an	an	DT
cord-288670-1vlowf2n	89	37	earlier	early	JJR
cord-288670-1vlowf2n	89	38	report	report	NN
cord-288670-1vlowf2n	89	39	in	in	IN
cord-288670-1vlowf2n	89	40	which	which	WDT
cord-288670-1vlowf2n	89	41	SARS	SARS	NNP
cord-288670-1vlowf2n	89	42	-	-	HYPH
cord-288670-1vlowf2n	89	43	CoV	CoV	NNP
cord-288670-1vlowf2n	89	44	entry	entry	NN
cord-288670-1vlowf2n	89	45	into	into	IN
cord-288670-1vlowf2n	89	46	HepG2	HepG2	NNP
cord-288670-1vlowf2n	89	47	cells	cell	NNS
cord-288670-1vlowf2n	89	48	is	be	VBZ
cord-288670-1vlowf2n	89	49	mostly	mostly	RB
cord-288670-1vlowf2n	89	50	mediated	mediate	VBN
cord-288670-1vlowf2n	89	51	by	by	IN
cord-288670-1vlowf2n	89	52	the	the	DT
cord-288670-1vlowf2n	89	53	clathrin	clathrin	NN
cord-288670-1vlowf2n	89	54	-	-	HYPH
cord-288670-1vlowf2n	89	55	dependent	dependent	JJ
cord-288670-1vlowf2n	89	56	pathway	pathway	NN
cord-288670-1vlowf2n	89	57	[	[	-LRB-
cord-288670-1vlowf2n	89	58	39	39	CD
cord-288670-1vlowf2n	89	59	]	]	-RRB-
cord-288670-1vlowf2n	89	60	.	.	.
cord-288670-1vlowf2n	90	1	Part	part	NN
cord-288670-1vlowf2n	90	2	of	of	IN
cord-288670-1vlowf2n	90	3	the	the	DT
cord-288670-1vlowf2n	90	4	reason	reason	NN
cord-288670-1vlowf2n	90	5	for	for	IN
cord-288670-1vlowf2n	90	6	such	such	JJ
cord-288670-1vlowf2n	90	7	discrepancies	discrepancy	NNS
cord-288670-1vlowf2n	90	8	is	be	VBZ
cord-288670-1vlowf2n	90	9	the	the	DT
cord-288670-1vlowf2n	90	10	different	different	JJ
cord-288670-1vlowf2n	90	11	cell	cell	NN
cord-288670-1vlowf2n	90	12	types	type	NNS
cord-288670-1vlowf2n	90	13	used	use	VBN
cord-288670-1vlowf2n	90	14	in	in	IN
cord-288670-1vlowf2n	90	15	their	-PRON-	PRP$
cord-288670-1vlowf2n	90	16	studies	study	NNS
cord-288670-1vlowf2n	90	17	,	,	,
cord-288670-1vlowf2n	90	18	as	as	IN
cord-288670-1vlowf2n	90	19	shown	show	VBN
cord-288670-1vlowf2n	90	20	in	in	IN
cord-288670-1vlowf2n	90	21	Table	Table	NNP
cord-288670-1vlowf2n	90	22	2	2	CD
cord-288670-1vlowf2n	90	23	.	.	.
cord-288670-1vlowf2n	91	1	Therefore	therefore	RB
cord-288670-1vlowf2n	91	2	,	,	,
cord-288670-1vlowf2n	91	3	it	-PRON-	PRP
cord-288670-1vlowf2n	91	4	is	be	VBZ
cord-288670-1vlowf2n	91	5	possible	possible	JJ
cord-288670-1vlowf2n	91	6	that	that	IN
cord-288670-1vlowf2n	91	7	the	the	DT
cord-288670-1vlowf2n	91	8	exact	exact	JJ
cord-288670-1vlowf2n	91	9	nature	nature	NN
cord-288670-1vlowf2n	91	10	of	of	IN
cord-288670-1vlowf2n	91	11	the	the	DT
cord-288670-1vlowf2n	91	12	entry	entry	NN
cord-288670-1vlowf2n	91	13	is	be	VBZ
cord-288670-1vlowf2n	91	14	context	context	NN
cord-288670-1vlowf2n	91	15	-	-	HYPH
cord-288670-1vlowf2n	91	16	dependent	dependent	JJ
cord-288670-1vlowf2n	91	17	,	,	,
cord-288670-1vlowf2n	91	18	including	include	VBG
cord-288670-1vlowf2n	91	19	the	the	DT
cord-288670-1vlowf2n	91	20	type	type	NN
cord-288670-1vlowf2n	91	21	of	of	IN
cord-288670-1vlowf2n	91	22	the	the	DT
cord-288670-1vlowf2n	91	23	virus	virus	NN
cord-288670-1vlowf2n	91	24	and	and	CC
cord-288670-1vlowf2n	91	25	the	the	DT
cord-288670-1vlowf2n	91	26	type	type	NN
cord-288670-1vlowf2n	91	27	of	of	IN
cord-288670-1vlowf2n	91	28	the	the	DT
cord-288670-1vlowf2n	91	29	cells	cell	NNS
cord-288670-1vlowf2n	91	30	.	.	.
cord-288670-1vlowf2n	92	1	Third	third	RB
cord-288670-1vlowf2n	92	2	,	,	,
cord-288670-1vlowf2n	92	3	at	at	IN
cord-288670-1vlowf2n	92	4	present	present	NN
cord-288670-1vlowf2n	92	5	,	,	,
cord-288670-1vlowf2n	92	6	the	the	DT
cord-288670-1vlowf2n	92	7	entry	entry	NN
cord-288670-1vlowf2n	92	8	mechanisms	mechanism	NNS
cord-288670-1vlowf2n	92	9	and	and	CC
cord-288670-1vlowf2n	92	10	the	the	DT
cord-288670-1vlowf2n	92	11	implication	implication	NN
cord-288670-1vlowf2n	92	12	of	of	IN
cord-288670-1vlowf2n	92	13	the	the	DT
cord-288670-1vlowf2n	92	14	endocytic	endocytic	JJ
cord-288670-1vlowf2n	92	15	pathway	pathway	NN
cord-288670-1vlowf2n	92	16	of	of	IN
cord-288670-1vlowf2n	92	17	the	the	DT
cord-288670-1vlowf2n	92	18	new	new	JJ
cord-288670-1vlowf2n	92	19	emerging	emerge	VBG
cord-288670-1vlowf2n	92	20	SARS	SARS	NNP
cord-288670-1vlowf2n	92	21	-	-	HYPH
cord-288670-1vlowf2n	92	22	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	92	23	have	have	VBP
cord-288670-1vlowf2n	92	24	not	not	RB
cord-288670-1vlowf2n	92	25	been	be	VBN
cord-288670-1vlowf2n	92	26	reported	report	VBN
cord-288670-1vlowf2n	92	27	directly	directly	RB
cord-288670-1vlowf2n	92	28	.	.	.
cord-288670-1vlowf2n	93	1	It	-PRON-	PRP
cord-288670-1vlowf2n	93	2	is	be	VBZ
cord-288670-1vlowf2n	93	3	now	now	RB
cord-288670-1vlowf2n	93	4	known	know	VBN
cord-288670-1vlowf2n	93	5	that	that	IN
cord-288670-1vlowf2n	93	6	SARS	SARS	NNP
cord-288670-1vlowf2n	93	7	-	-	HYPH
cord-288670-1vlowf2n	93	8	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	93	9	utilizes	utilize	VBZ
cord-288670-1vlowf2n	93	10	the	the	DT
cord-288670-1vlowf2n	93	11	same	same	JJ
cord-288670-1vlowf2n	93	12	receptor	receptor	NN
cord-288670-1vlowf2n	93	13	of	of	IN
cord-288670-1vlowf2n	93	14	SARS	SARS	NNP
cord-288670-1vlowf2n	93	15	-	-	HYPH
cord-288670-1vlowf2n	93	16	CoV	CoV	NNP
cord-288670-1vlowf2n	93	17	,	,	,
cord-288670-1vlowf2n	93	18	which	which	WDT
cord-288670-1vlowf2n	93	19	is	be	VBZ
cord-288670-1vlowf2n	93	20	angiotensin	angiotensin	NN
cord-288670-1vlowf2n	93	21	converting	convert	VBG
cord-288670-1vlowf2n	93	22	enzyme	enzyme	NN
cord-288670-1vlowf2n	93	23	II	II	NNP
cord-288670-1vlowf2n	93	24	(	(	-LRB-
cord-288670-1vlowf2n	93	25	ACE2	ACE2	NNP
cord-288670-1vlowf2n	93	26	)	)	-RRB-
cord-288670-1vlowf2n	93	27	for	for	IN
cord-288670-1vlowf2n	93	28	viral	viral	JJ
cord-288670-1vlowf2n	93	29	entry	entry	NN
cord-288670-1vlowf2n	93	30	into	into	IN
cord-288670-1vlowf2n	93	31	the	the	DT
cord-288670-1vlowf2n	93	32	host	host	NN
cord-288670-1vlowf2n	93	33	cells	cell	NNS
cord-288670-1vlowf2n	93	34	[	[	-LRB-
cord-288670-1vlowf2n	93	35	5	5	CD
cord-288670-1vlowf2n	93	36	,	,	,
cord-288670-1vlowf2n	93	37	40	40	CD
cord-288670-1vlowf2n	93	38	]	]	-RRB-
cord-288670-1vlowf2n	93	39	.	.	.
cord-288670-1vlowf2n	94	1	ACE2	ACE2	NNP
cord-288670-1vlowf2n	94	2	transcripts	transcript	NNS
cord-288670-1vlowf2n	94	3	was	be	VBD
cord-288670-1vlowf2n	94	4	originally	originally	RB
cord-288670-1vlowf2n	94	5	only	only	RB
cord-288670-1vlowf2n	94	6	found	find	VBN
cord-288670-1vlowf2n	94	7	in	in	IN
cord-288670-1vlowf2n	94	8	heart	heart	NN
cord-288670-1vlowf2n	94	9	,	,	,
cord-288670-1vlowf2n	94	10	kidney	kidney	NN
cord-288670-1vlowf2n	94	11	and	and	CC
cord-288670-1vlowf2n	94	12	testis	testis	NN
cord-288670-1vlowf2n	94	13	of	of	IN
cord-288670-1vlowf2n	94	14	human	human	JJ
cord-288670-1vlowf2n	94	15	[	[	-LRB-
cord-288670-1vlowf2n	94	16	41	41	CD
cord-288670-1vlowf2n	94	17	]	]	-RRB-
cord-288670-1vlowf2n	94	18	.	.	.
cord-288670-1vlowf2n	95	1	However	however	RB
cord-288670-1vlowf2n	95	2	,	,	,
cord-288670-1vlowf2n	95	3	it	-PRON-	PRP
cord-288670-1vlowf2n	95	4	was	be	VBD
cord-288670-1vlowf2n	95	5	later	later	RB
cord-288670-1vlowf2n	95	6	found	find	VBN
cord-288670-1vlowf2n	95	7	that	that	IN
cord-288670-1vlowf2n	95	8	ACE2	ACE2	NNP
cord-288670-1vlowf2n	95	9	protein	protein	NN
cord-288670-1vlowf2n	95	10	expresses	express	VBZ
cord-288670-1vlowf2n	95	11	abundantly	abundantly	RB
cord-288670-1vlowf2n	95	12	in	in	IN
cord-288670-1vlowf2n	95	13	the	the	DT
cord-288670-1vlowf2n	95	14	epithelia	epithelium	NNS
cord-288670-1vlowf2n	95	15	of	of	IN
cord-288670-1vlowf2n	95	16	the	the	DT
cord-288670-1vlowf2n	95	17	human	human	JJ
cord-288670-1vlowf2n	95	18	lung	lung	NN
cord-288670-1vlowf2n	95	19	and	and	CC
cord-288670-1vlowf2n	95	20	small	small	JJ
cord-288670-1vlowf2n	95	21	intestine	intestine	NN
cord-288670-1vlowf2n	95	22	[	[	-LRB-
cord-288670-1vlowf2n	95	23	42	42	CD
cord-288670-1vlowf2n	95	24	]	]	-RRB-
cord-288670-1vlowf2n	95	25	.	.	.
cord-288670-1vlowf2n	96	1	Since	since	IN
cord-288670-1vlowf2n	96	2	SARS	SARS	NNP
cord-288670-1vlowf2n	96	3	-	-	HYPH
cord-288670-1vlowf2n	96	4	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	96	5	also	also	RB
cord-288670-1vlowf2n	96	6	binds	bind	VBZ
cord-288670-1vlowf2n	96	7	to	to	IN
cord-288670-1vlowf2n	96	8	the	the	DT
cord-288670-1vlowf2n	96	9	same	same	JJ
cord-288670-1vlowf2n	96	10	ACE2	ACE2	NNP
cord-288670-1vlowf2n	96	11	receptor	receptor	NN
cord-288670-1vlowf2n	96	12	as	as	IN
cord-288670-1vlowf2n	96	13	SARS	SARS	NNP
cord-288670-1vlowf2n	96	14	-	-	HYPH
cord-288670-1vlowf2n	96	15	CoV	CoV	NNP
cord-288670-1vlowf2n	96	16	[	[	-LRB-
cord-288670-1vlowf2n	96	17	5	5	CD
cord-288670-1vlowf2n	96	18	]	]	-RRB-
cord-288670-1vlowf2n	96	19	and	and	CC
cord-288670-1vlowf2n	96	20	SARS	SARS	NNP
cord-288670-1vlowf2n	96	21	-	-	HYPH
cord-288670-1vlowf2n	96	22	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	96	23	is	be	VBZ
cord-288670-1vlowf2n	96	24	also	also	RB
cord-288670-1vlowf2n	96	25	susceptible	susceptible	JJ
cord-288670-1vlowf2n	96	26	to	to	IN
cord-288670-1vlowf2n	96	27	the	the	DT
cord-288670-1vlowf2n	96	28	inhibitory	inhibitory	JJ
cord-288670-1vlowf2n	96	29	effect	effect	NN
cord-288670-1vlowf2n	96	30	of	of	IN
cord-288670-1vlowf2n	96	31	chloroquine	chloroquine	NN
cord-288670-1vlowf2n	96	32	(	(	-LRB-
cord-288670-1vlowf2n	96	33	CQ	CQ	NNP
cord-288670-1vlowf2n	96	34	)	)	-RRB-
cord-288670-1vlowf2n	96	35	,	,	,
cord-288670-1vlowf2n	96	36	a	a	DT
cord-288670-1vlowf2n	96	37	lysosomotropic	lysosomotropic	JJ
cord-288670-1vlowf2n	96	38	agent	agent	NN
cord-288670-1vlowf2n	96	39	[	[	-LRB-
cord-288670-1vlowf2n	96	40	43	43	CD
cord-288670-1vlowf2n	96	41	]	]	-RRB-
cord-288670-1vlowf2n	97	1	,	,	,
cord-288670-1vlowf2n	97	2	it	-PRON-	PRP
cord-288670-1vlowf2n	97	3	is	be	VBZ
cord-288670-1vlowf2n	97	4	highly	highly	RB
cord-288670-1vlowf2n	97	5	possible	possible	JJ
cord-288670-1vlowf2n	97	6	that	that	IN
cord-288670-1vlowf2n	97	7	this	this	DT
cord-288670-1vlowf2n	97	8	new	new	JJ
cord-288670-1vlowf2n	97	9	CoV	cov	NN
cord-288670-1vlowf2n	97	10	utilizes	utilize	VBZ
cord-288670-1vlowf2n	97	11	the	the	DT
cord-288670-1vlowf2n	97	12	same	same	JJ
cord-288670-1vlowf2n	97	13	endocytic	endocytic	JJ
cord-288670-1vlowf2n	97	14	pathway	pathway	NN
cord-288670-1vlowf2n	97	15	for	for	IN
cord-288670-1vlowf2n	97	16	entry	entry	NN
cord-288670-1vlowf2n	97	17	into	into	IN
cord-288670-1vlowf2n	97	18	the	the	DT
cord-288670-1vlowf2n	97	19	host	host	NN
cord-288670-1vlowf2n	97	20	cells	cell	NNS
cord-288670-1vlowf2n	97	21	.	.	.
cord-288670-1vlowf2n	98	1	Understanding	understand	VBG
cord-288670-1vlowf2n	98	2	this	this	DT
cord-288670-1vlowf2n	98	3	mechanism	mechanism	NN
cord-288670-1vlowf2n	98	4	is	be	VBZ
cord-288670-1vlowf2n	98	5	important	important	JJ
cord-288670-1vlowf2n	98	6	in	in	IN
cord-288670-1vlowf2n	98	7	the	the	DT
cord-288670-1vlowf2n	98	8	search	search	NN
cord-288670-1vlowf2n	98	9	of	of	IN
cord-288670-1vlowf2n	98	10	effective	effective	JJ
cord-288670-1vlowf2n	98	11	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	98	12	agents	agent	NNS
cord-288670-1vlowf2n	98	13	in	in	IN
cord-288670-1vlowf2n	98	14	the	the	DT
cord-288670-1vlowf2n	98	15	treatment	treatment	NN
cord-288670-1vlowf2n	98	16	of	of	IN
cord-288670-1vlowf2n	98	17	COVID-19	covid-19	NN
cord-288670-1vlowf2n	98	18	caused	cause	VBN
cord-288670-1vlowf2n	98	19	by	by	IN
cord-288670-1vlowf2n	98	20	this	this	DT
cord-288670-1vlowf2n	98	21	new	new	JJ
cord-288670-1vlowf2n	98	22	CoV.	CoV.	NNP
cord-288670-1vlowf2n	98	23	Finally	finally	RB
cord-288670-1vlowf2n	98	24	,	,	,
cord-288670-1vlowf2n	98	25	in	in	IN
cord-288670-1vlowf2n	98	26	almost	almost	RB
cord-288670-1vlowf2n	98	27	all	all	PDT
cord-288670-1vlowf2n	98	28	the	the	DT
cord-288670-1vlowf2n	98	29	studies	study	NNS
cord-288670-1vlowf2n	98	30	listed	list	VBN
cord-288670-1vlowf2n	98	31	in	in	IN
cord-288670-1vlowf2n	98	32	Table	Table	NNP
cord-288670-1vlowf2n	98	33	2	2	CD
cord-288670-1vlowf2n	98	34	,	,	,
cord-288670-1vlowf2n	98	35	different	different	JJ
cord-288670-1vlowf2n	98	36	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	98	37	of	of	IN
cord-288670-1vlowf2n	98	38	the	the	DT
cord-288670-1vlowf2n	98	39	endocytic	endocytic	JJ
cord-288670-1vlowf2n	98	40	pathway	pathway	NN
cord-288670-1vlowf2n	98	41	have	have	VBP
cord-288670-1vlowf2n	98	42	been	be	VBN
cord-288670-1vlowf2n	98	43	used	use	VBN
cord-288670-1vlowf2n	98	44	in	in	IN
cord-288670-1vlowf2n	98	45	blocking	block	VBG
cord-288670-1vlowf2n	98	46	viral	viral	JJ
cord-288670-1vlowf2n	98	47	entry	entry	NN
cord-288670-1vlowf2n	98	48	and	and	CC
cord-288670-1vlowf2n	98	49	infection	infection	NN
cord-288670-1vlowf2n	98	50	.	.	.
cord-288670-1vlowf2n	99	1	Among	among	IN
cord-288670-1vlowf2n	99	2	them	-PRON-	PRP
cord-288670-1vlowf2n	99	3	,	,	,
cord-288670-1vlowf2n	99	4	three	three	CD
cord-288670-1vlowf2n	99	5	groups	group	NNS
cord-288670-1vlowf2n	99	6	of	of	IN
cord-288670-1vlowf2n	99	7	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	99	8	are	be	VBP
cord-288670-1vlowf2n	99	9	believed	believe	VBN
cord-288670-1vlowf2n	99	10	to	to	TO
cord-288670-1vlowf2n	99	11	be	be	VB
cord-288670-1vlowf2n	99	12	particularly	particularly	RB
cord-288670-1vlowf2n	99	13	important	important	JJ
cord-288670-1vlowf2n	99	14	and	and	CC
cord-288670-1vlowf2n	99	15	clinically	clinically	RB
cord-288670-1vlowf2n	99	16	relevant	relevant	JJ
cord-288670-1vlowf2n	99	17	.	.	.
cord-288670-1vlowf2n	100	1	The	the	DT
cord-288670-1vlowf2n	100	2	first	first	JJ
cord-288670-1vlowf2n	100	3	group	group	NN
cord-288670-1vlowf2n	100	4	are	be	VBP
cord-288670-1vlowf2n	100	5	the	the	DT
cord-288670-1vlowf2n	100	6	lysosomotropic	lysosomotropic	JJ
cord-288670-1vlowf2n	100	7	agents	agent	NNS
cord-288670-1vlowf2n	100	8	which	which	WDT
cord-288670-1vlowf2n	100	9	are	be	VBP
cord-288670-1vlowf2n	100	10	capable	capable	JJ
cord-288670-1vlowf2n	100	11	of	of	IN
cord-288670-1vlowf2n	100	12	accumulating	accumulate	VBG
cord-288670-1vlowf2n	100	13	inside	inside	RB
cord-288670-1vlowf2n	100	14	and	and	CC
cord-288670-1vlowf2n	100	15	neutralizing	neutralize	VBG
cord-288670-1vlowf2n	100	16	the	the	DT
cord-288670-1vlowf2n	100	17	endosome	endosome	NN
cord-288670-1vlowf2n	100	18	-	-	HYPH
cord-288670-1vlowf2n	100	19	lysosomal	lysosomal	VBG
cord-288670-1vlowf2n	100	20	acidic	acidic	JJ
cord-288670-1vlowf2n	100	21	pH	ph	NN
cord-288670-1vlowf2n	100	22	and	and	CC
cord-288670-1vlowf2n	100	23	thus	thus	RB
cord-288670-1vlowf2n	100	24	blocking	block	VBG
cord-288670-1vlowf2n	100	25	the	the	DT
cord-288670-1vlowf2n	100	26	protease	protease	NN
cord-288670-1vlowf2n	100	27	activity	activity	NN
cord-288670-1vlowf2n	100	28	to	to	TO
cord-288670-1vlowf2n	100	29	inhibit	inhibit	VB
cord-288670-1vlowf2n	100	30	the	the	DT
cord-288670-1vlowf2n	100	31	viral	viral	JJ
cord-288670-1vlowf2n	100	32	entry	entry	NN
cord-288670-1vlowf2n	100	33	.	.	.
cord-288670-1vlowf2n	101	1	In	in	IN
cord-288670-1vlowf2n	101	2	this	this	DT
cord-288670-1vlowf2n	101	3	group	group	NN
cord-288670-1vlowf2n	101	4	,	,	,
cord-288670-1vlowf2n	101	5	CQ	CQ	NNP
cord-288670-1vlowf2n	101	6	is	be	VBZ
cord-288670-1vlowf2n	101	7	an	an	DT
cord-288670-1vlowf2n	101	8	ancient	ancient	JJ
cord-288670-1vlowf2n	101	9	anti	anti	JJ
cord-288670-1vlowf2n	101	10	-	-	JJ
cord-288670-1vlowf2n	101	11	malaria	malaria	JJ
cord-288670-1vlowf2n	101	12	drug	drug	NN
cord-288670-1vlowf2n	101	13	and	and	CC
cord-288670-1vlowf2n	101	14	clinically	clinically	RB
cord-288670-1vlowf2n	101	15	available	available	JJ
cord-288670-1vlowf2n	101	16	,	,	,
cord-288670-1vlowf2n	101	17	as	as	IN
cord-288670-1vlowf2n	101	18	shown	show	VBN
cord-288670-1vlowf2n	101	19	in	in	IN
cord-288670-1vlowf2n	101	20	Figure	figure	NN
cord-288670-1vlowf2n	101	21	1	1	CD
cord-288670-1vlowf2n	101	22	.	.	.
cord-288670-1vlowf2n	102	1	The	the	DT
cord-288670-1vlowf2n	102	2	second	second	JJ
cord-288670-1vlowf2n	102	3	group	group	NN
cord-288670-1vlowf2n	102	4	are	be	VBP
cord-288670-1vlowf2n	102	5	direct	direct	JJ
cord-288670-1vlowf2n	102	6	endosomal	endosomal	NN
cord-288670-1vlowf2n	102	7	-	-	HYPH
cord-288670-1vlowf2n	102	8	lysosomal	lysosomal	NN
cord-288670-1vlowf2n	102	9	protease	protease	NN
cord-288670-1vlowf2n	102	10	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	102	11	such	such	JJ
cord-288670-1vlowf2n	102	12	as	as	IN
cord-288670-1vlowf2n	102	13	E64d	E64d	NNS
cord-288670-1vlowf2n	102	14	.	.	.
cord-288670-1vlowf2n	103	1	And	and	CC
cord-288670-1vlowf2n	103	2	the	the	DT
cord-288670-1vlowf2n	103	3	third	third	JJ
cord-288670-1vlowf2n	103	4	group	group	NN
cord-288670-1vlowf2n	103	5	are	be	VBP
cord-288670-1vlowf2n	103	6	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	103	7	for	for	IN
cord-288670-1vlowf2n	103	8	the	the	DT
cord-288670-1vlowf2n	103	9	clathrin	clathrin	NN
cord-288670-1vlowf2n	103	10	-	-	HYPH
cord-288670-1vlowf2n	103	11	mediated	mediate	VBN
cord-288670-1vlowf2n	103	12	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	103	13	such	such	JJ
cord-288670-1vlowf2n	103	14	as	as	IN
cord-288670-1vlowf2n	103	15	chlorpromazine	chlorpromazine	NN
cord-288670-1vlowf2n	103	16	,	,	,
cord-288670-1vlowf2n	103	17	which	which	WDT
cord-288670-1vlowf2n	103	18	is	be	VBZ
cord-288670-1vlowf2n	103	19	also	also	RB
cord-288670-1vlowf2n	103	20	clinically	clinically	RB
cord-288670-1vlowf2n	103	21	available	available	JJ
cord-288670-1vlowf2n	103	22	(	(	-LRB-
cord-288670-1vlowf2n	103	23	Figure	figure	NN
cord-288670-1vlowf2n	103	24	1	1	CD
cord-288670-1vlowf2n	103	25	)	)	-RRB-
cord-288670-1vlowf2n	103	26	.	.	.
cord-288670-1vlowf2n	104	1	The	the	DT
cord-288670-1vlowf2n	104	2	details	detail	NNS
cord-288670-1vlowf2n	104	3	of	of	IN
cord-288670-1vlowf2n	104	4	such	such	JJ
cord-288670-1vlowf2n	104	5	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	104	6	are	be	VBP
cord-288670-1vlowf2n	104	7	to	to	TO
cord-288670-1vlowf2n	104	8	be	be	VB
cord-288670-1vlowf2n	104	9	discussed	discuss	VBN
cord-288670-1vlowf2n	104	10	in	in	IN
cord-288670-1vlowf2n	104	11	the	the	DT
cord-288670-1vlowf2n	104	12	section	section	NN
cord-288670-1vlowf2n	104	13	below	below	RB
cord-288670-1vlowf2n	104	14	.	.	.
cord-288670-1vlowf2n	105	1	Taken	take	VBN
cord-288670-1vlowf2n	105	2	together	together	RB
cord-288670-1vlowf2n	105	3	,	,	,
cord-288670-1vlowf2n	105	4	establishing	establish	VBG
cord-288670-1vlowf2n	105	5	the	the	DT
cord-288670-1vlowf2n	105	6	role	role	NN
cord-288670-1vlowf2n	105	7	of	of	IN
cord-288670-1vlowf2n	105	8	endocytic	endocytic	JJ
cord-288670-1vlowf2n	105	9	pathway	pathway	NN
cord-288670-1vlowf2n	105	10	in	in	IN
cord-288670-1vlowf2n	105	11	viral	viral	JJ
cord-288670-1vlowf2n	105	12	entry	entry	NN
cord-288670-1vlowf2n	105	13	is	be	VBZ
cord-288670-1vlowf2n	105	14	a	a	DT
cord-288670-1vlowf2n	105	15	major	major	JJ
cord-288670-1vlowf2n	105	16	breakthrough	breakthrough	NN
cord-288670-1vlowf2n	105	17	in	in	IN
cord-288670-1vlowf2n	105	18	the	the	DT
cord-288670-1vlowf2n	105	19	mechanistic	mechanistic	JJ
cord-288670-1vlowf2n	105	20	understanding	understanding	NN
cord-288670-1vlowf2n	105	21	of	of	IN
cord-288670-1vlowf2n	105	22	the	the	DT
cord-288670-1vlowf2n	105	23	CoVs	CoVs	NNP
cord-288670-1vlowf2n	105	24	infection	infection	NN
cord-288670-1vlowf2n	105	25	,	,	,
cord-288670-1vlowf2n	105	26	which	which	WDT
cord-288670-1vlowf2n	105	27	offers	offer	VBZ
cord-288670-1vlowf2n	105	28	great	great	JJ
cord-288670-1vlowf2n	105	29	opportunity	opportunity	NN
cord-288670-1vlowf2n	105	30	in	in	IN
cord-288670-1vlowf2n	105	31	development	development	NN
cord-288670-1vlowf2n	105	32	of	of	IN
cord-288670-1vlowf2n	105	33	novel	novel	JJ
cord-288670-1vlowf2n	105	34	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	105	35	strategies	strategy	NNS
cord-288670-1vlowf2n	105	36	for	for	IN
cord-288670-1vlowf2n	105	37	treatment	treatment	NN
cord-288670-1vlowf2n	105	38	of	of	IN
cord-288670-1vlowf2n	105	39	diseases	disease	NNS
cord-288670-1vlowf2n	105	40	such	such	JJ
cord-288670-1vlowf2n	105	41	as	as	IN
cord-288670-1vlowf2n	105	42	SARS	SARS	NNP
cord-288670-1vlowf2n	105	43	and	and	CC
cord-288670-1vlowf2n	105	44	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	105	45	.	.	.
cord-288670-1vlowf2n	106	1	Lysosomotropic	lysosomotropic	JJ
cord-288670-1vlowf2n	106	2	agents	agent	NNS
cord-288670-1vlowf2n	106	3	targeting	target	VBG
cord-288670-1vlowf2n	106	4	endosomal/	endosomal/	JJ
cord-288670-1vlowf2n	106	5	lysosomal	lysosomal	NN
cord-288670-1vlowf2n	106	6	pH	pH	NNP
cord-288670-1vlowf2n	106	7	CQ	CQ	NNP
cord-288670-1vlowf2n	106	8	,	,	,
cord-288670-1vlowf2n	106	9	a	a	DT
cord-288670-1vlowf2n	106	10	well	well	RB
cord-288670-1vlowf2n	106	11	-	-	HYPH
cord-288670-1vlowf2n	106	12	known	know	VBN
cord-288670-1vlowf2n	106	13	anti	anti	JJ
cord-288670-1vlowf2n	106	14	-	-	JJ
cord-288670-1vlowf2n	106	15	malarial	malarial	JJ
cord-288670-1vlowf2n	106	16	drug	drug	NN
cord-288670-1vlowf2n	106	17	,	,	,
cord-288670-1vlowf2n	106	18	is	be	VBZ
cord-288670-1vlowf2n	106	19	probably	probably	RB
cord-288670-1vlowf2n	106	20	the	the	DT
cord-288670-1vlowf2n	106	21	most	most	RBS
cord-288670-1vlowf2n	106	22	well	well	RB
cord-288670-1vlowf2n	106	23	-	-	HYPH
cord-288670-1vlowf2n	106	24	studied	study	VBN
cord-288670-1vlowf2n	106	25	lysosomotropic	lysosomotropic	JJ
cord-288670-1vlowf2n	106	26	agent	agent	NN
cord-288670-1vlowf2n	106	27	that	that	WDT
cord-288670-1vlowf2n	106	28	accumulates	accumulate	VBZ
cord-288670-1vlowf2n	106	29	in	in	IN
cord-288670-1vlowf2n	106	30	the	the	DT
cord-288670-1vlowf2n	106	31	acidic	acidic	JJ
cord-288670-1vlowf2n	106	32	organelles	organelle	NNS
cord-288670-1vlowf2n	106	33	such	such	JJ
cord-288670-1vlowf2n	106	34	as	as	IN
cord-288670-1vlowf2n	106	35	endosomes	endosome	NNS
cord-288670-1vlowf2n	106	36	and	and	CC
cord-288670-1vlowf2n	106	37	lysosomes	lysosome	NNS
cord-288670-1vlowf2n	106	38	and	and	CC
cord-288670-1vlowf2n	106	39	neutralizes	neutralize	VBZ
cord-288670-1vlowf2n	106	40	their	-PRON-	PRP$
cord-288670-1vlowf2n	106	41	pH	ph	XX
cord-288670-1vlowf2n	106	42	[	[	-LRB-
cord-288670-1vlowf2n	106	43	57	57	CD
cord-288670-1vlowf2n	106	44	]	]	-RRB-
cord-288670-1vlowf2n	106	45	.	.	.
cord-288670-1vlowf2n	107	1	At	at	IN
cord-288670-1vlowf2n	107	2	present	present	NN
cord-288670-1vlowf2n	107	3	,	,	,
cord-288670-1vlowf2n	107	4	it	-PRON-	PRP
cord-288670-1vlowf2n	107	5	has	have	VBZ
cord-288670-1vlowf2n	107	6	been	be	VBN
cord-288670-1vlowf2n	107	7	well	well	RB
cord-288670-1vlowf2n	107	8	studied	study	VBN
cord-288670-1vlowf2n	107	9	that	that	IN
cord-288670-1vlowf2n	107	10	CQ	CQ	NNP
cord-288670-1vlowf2n	107	11	has	have	VBZ
cord-288670-1vlowf2n	107	12	a	a	DT
cord-288670-1vlowf2n	107	13	wide	wide	JJ
cord-288670-1vlowf2n	107	14	-	-	HYPH
cord-288670-1vlowf2n	107	15	spectrum	spectrum	NN
cord-288670-1vlowf2n	107	16	of	of	IN
cord-288670-1vlowf2n	107	17	anti	anti	JJ
cord-288670-1vlowf2n	107	18	-	-	JJ
cord-288670-1vlowf2n	107	19	viral	viral	JJ
cord-288670-1vlowf2n	107	20	effects	effect	NNS
cord-288670-1vlowf2n	107	21	including	include	VBG
cord-288670-1vlowf2n	107	22	anti	anti	JJ
cord-288670-1vlowf2n	107	23	-	-	JJ
cord-288670-1vlowf2n	107	24	CoVs	covs	JJ
cord-288670-1vlowf2n	107	25	,	,	,
cord-288670-1vlowf2n	107	26	anti	anti	JJ
cord-288670-1vlowf2n	107	27	-	-	JJ
cord-288670-1vlowf2n	107	28	HIV	HIV	NNP
cord-288670-1vlowf2n	107	29	,	,	,
cord-288670-1vlowf2n	107	30	and	and	CC
cord-288670-1vlowf2n	107	31	anti	anti	JJ
cord-288670-1vlowf2n	107	32	-	-	JJ
cord-288670-1vlowf2n	107	33	type	type	JJ
cord-288670-1vlowf2n	107	34	A	a	NN
cord-288670-1vlowf2n	107	35	and	and	CC
cord-288670-1vlowf2n	107	36	B	b	NN
cord-288670-1vlowf2n	107	37	influenza	influenza	NN
cord-288670-1vlowf2n	107	38	viruses	virus	NNS
cord-288670-1vlowf2n	107	39	[	[	-LRB-
cord-288670-1vlowf2n	107	40	58	58	CD
cord-288670-1vlowf2n	107	41	]	]	-RRB-
cord-288670-1vlowf2n	107	42	.	.	.
cord-288670-1vlowf2n	108	1	The	the	DT
cord-288670-1vlowf2n	108	2	anti	anti	JJ
cord-288670-1vlowf2n	108	3	-	-	JJ
cord-288670-1vlowf2n	108	4	viral	viral	JJ
cord-288670-1vlowf2n	108	5	effects	effect	NNS
cord-288670-1vlowf2n	108	6	of	of	IN
cord-288670-1vlowf2n	108	7	CQ	CQ	NNP
cord-288670-1vlowf2n	108	8	and	and	CC
cord-288670-1vlowf2n	108	9	its	-PRON-	PRP$
cord-288670-1vlowf2n	108	10	analogs	analog	NNS
cord-288670-1vlowf2n	108	11	have	have	VBP
cord-288670-1vlowf2n	108	12	been	be	VBN
cord-288670-1vlowf2n	108	13	reviewed	review	VBN
cord-288670-1vlowf2n	108	14	elsewhere	elsewhere	RB
cord-288670-1vlowf2n	108	15	[	[	-LRB-
cord-288670-1vlowf2n	108	16	59	59	CD
cord-288670-1vlowf2n	108	17	]	]	-RRB-
cord-288670-1vlowf2n	108	18	.	.	.
cord-288670-1vlowf2n	109	1	Here	here	RB
cord-288670-1vlowf2n	109	2	we	-PRON-	PRP
cord-288670-1vlowf2n	109	3	would	would	MD
cord-288670-1vlowf2n	109	4	like	like	VB
cord-288670-1vlowf2n	109	5	to	to	TO
cord-288670-1vlowf2n	109	6	focus	focus	VB
cord-288670-1vlowf2n	109	7	on	on	IN
cord-288670-1vlowf2n	109	8	the	the	DT
cord-288670-1vlowf2n	109	9	effect	effect	NN
cord-288670-1vlowf2n	109	10	of	of	IN
cord-288670-1vlowf2n	109	11	CQ	CQ	NNP
cord-288670-1vlowf2n	109	12	on	on	IN
cord-288670-1vlowf2n	109	13	CoVs	CoVs	NNP
cord-288670-1vlowf2n	109	14	,	,	,
cord-288670-1vlowf2n	109	15	as	as	IN
cord-288670-1vlowf2n	109	16	summarized	summarize	VBN
cord-288670-1vlowf2n	109	17	in	in	IN
cord-288670-1vlowf2n	109	18	Table	Table	NNP
cord-288670-1vlowf2n	109	19	2	2	CD
cord-288670-1vlowf2n	109	20	.	.	.
cord-288670-1vlowf2n	110	1	For	for	IN
cord-288670-1vlowf2n	110	2	instance	instance	NN
cord-288670-1vlowf2n	110	3	,	,	,
cord-288670-1vlowf2n	110	4	CQ	CQ	NNP
cord-288670-1vlowf2n	110	5	has	have	VBZ
cord-288670-1vlowf2n	110	6	been	be	VBN
cord-288670-1vlowf2n	110	7	shown	show	VBN
cord-288670-1vlowf2n	110	8	to	to	TO
cord-288670-1vlowf2n	110	9	inhibit	inhibit	VB
cord-288670-1vlowf2n	110	10	MERS	MERS	NNP
cord-288670-1vlowf2n	110	11	-	-	HYPH
cord-288670-1vlowf2n	110	12	CoV	cov	NN
cord-288670-1vlowf2n	110	13	replication	replication	NN
cord-288670-1vlowf2n	110	14	in	in	IN
cord-288670-1vlowf2n	110	15	vitro	vitro	FW
cord-288670-1vlowf2n	110	16	via	via	IN
cord-288670-1vlowf2n	110	17	a	a	DT
cord-288670-1vlowf2n	110	18	screening	screening	NN
cord-288670-1vlowf2n	110	19	of	of	IN
cord-288670-1vlowf2n	110	20	an	an	DT
cord-288670-1vlowf2n	110	21	FDA	FDA	NNP
cord-288670-1vlowf2n	110	22	-	-	HYPH
cord-288670-1vlowf2n	110	23	approved	approve	VBN
cord-288670-1vlowf2n	110	24	compound	compound	NN
cord-288670-1vlowf2n	110	25	library	library	NN
cord-288670-1vlowf2n	110	26	[	[	-LRB-
cord-288670-1vlowf2n	110	27	60	60	CD
cord-288670-1vlowf2n	110	28	]	]	-RRB-
cord-288670-1vlowf2n	110	29	.	.	.
cord-288670-1vlowf2n	111	1	Treatment	treatment	NN
cord-288670-1vlowf2n	111	2	with	with	IN
cord-288670-1vlowf2n	111	3	CQ	CQ	NNP
cord-288670-1vlowf2n	111	4	at	at	IN
cord-288670-1vlowf2n	111	5	a	a	DT
cord-288670-1vlowf2n	111	6	clinically	clinically	RB
cord-288670-1vlowf2n	111	7	relevant	relevant	JJ
cord-288670-1vlowf2n	111	8	concentration	concentration	NN
cord-288670-1vlowf2n	111	9	,	,	,
cord-288670-1vlowf2n	111	10	either	either	CC
cord-288670-1vlowf2n	111	11	before	before	IN
cord-288670-1vlowf2n	111	12	or	or	CC
cord-288670-1vlowf2n	111	13	after	after	IN
cord-288670-1vlowf2n	111	14	SARS	SARS	NNP
cord-288670-1vlowf2n	111	15	-	-	HYPH
cord-288670-1vlowf2n	111	16	CoV	CoV	NNP
cord-288670-1vlowf2n	111	17	infection	infection	NN
cord-288670-1vlowf2n	111	18	into	into	IN
cord-288670-1vlowf2n	111	19	the	the	DT
cord-288670-1vlowf2n	111	20	Vero	Vero	NNP
cord-288670-1vlowf2n	111	21	E6	E6	NNP
cord-288670-1vlowf2n	111	22	cells	cell	NNS
cord-288670-1vlowf2n	111	23	,	,	,
cord-288670-1vlowf2n	111	24	was	be	VBD
cord-288670-1vlowf2n	111	25	found	find	VBN
cord-288670-1vlowf2n	111	26	to	to	TO
cord-288670-1vlowf2n	111	27	be	be	VB
cord-288670-1vlowf2n	111	28	effective	effective	JJ
cord-288670-1vlowf2n	111	29	in	in	IN
cord-288670-1vlowf2n	111	30	suppressing	suppress	VBG
cord-288670-1vlowf2n	111	31	viral	viral	JJ
cord-288670-1vlowf2n	111	32	infection	infection	NN
cord-288670-1vlowf2n	111	33	,	,	,
cord-288670-1vlowf2n	111	34	indicating	indicate	VBG
cord-288670-1vlowf2n	111	35	its	-PRON-	PRP$
cord-288670-1vlowf2n	111	36	application	application	NN
cord-288670-1vlowf2n	111	37	in	in	IN
cord-288670-1vlowf2n	111	38	both	both	CC
cord-288670-1vlowf2n	111	39	prophylactic	prophylactic	JJ
cord-288670-1vlowf2n	111	40	and	and	CC
cord-288670-1vlowf2n	111	41	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	111	42	conditions	condition	NNS
cord-288670-1vlowf2n	111	43	[	[	-LRB-
cord-288670-1vlowf2n	111	44	47	47	CD
cord-288670-1vlowf2n	111	45	]	]	-RRB-
cord-288670-1vlowf2n	111	46	.	.	.
cord-288670-1vlowf2n	112	1	Similar	similar	JJ
cord-288670-1vlowf2n	112	2	results	result	NNS
cord-288670-1vlowf2n	112	3	were	be	VBD
cord-288670-1vlowf2n	112	4	also	also	RB
cord-288670-1vlowf2n	112	5	found	find	VBN
cord-288670-1vlowf2n	112	6	in	in	IN
cord-288670-1vlowf2n	112	7	another	another	DT
cord-288670-1vlowf2n	112	8	lysosomotropic	lysosomotropic	JJ
cord-288670-1vlowf2n	112	9	agent	agent	NN
cord-288670-1vlowf2n	112	10	,	,	,
cord-288670-1vlowf2n	112	11	ammonium	ammonium	NN
cord-288670-1vlowf2n	112	12	chloride	chloride	NN
cord-288670-1vlowf2n	112	13	(	(	-LRB-
cord-288670-1vlowf2n	112	14	NH4Cl	NH4Cl	NNP
cord-288670-1vlowf2n	112	15	)	)	-RRB-
cord-288670-1vlowf2n	112	16	[	[	-LRB-
cord-288670-1vlowf2n	112	17	47	47	CD
cord-288670-1vlowf2n	112	18	]	]	-RRB-
cord-288670-1vlowf2n	112	19	.	.	.
cord-288670-1vlowf2n	113	1	It	-PRON-	PRP
cord-288670-1vlowf2n	113	2	is	be	VBZ
cord-288670-1vlowf2n	113	3	known	know	VBN
cord-288670-1vlowf2n	113	4	that	that	IN
cord-288670-1vlowf2n	113	5	the	the	DT
cord-288670-1vlowf2n	113	6	cleavage	cleavage	NN
cord-288670-1vlowf2n	113	7	of	of	IN
cord-288670-1vlowf2n	113	8	the	the	DT
cord-288670-1vlowf2n	113	9	Spike	Spike	NNP
cord-288670-1vlowf2n	113	10	Glycoprotein	Glycoprotein	NNP
cord-288670-1vlowf2n	113	11	(	(	-LRB-
cord-288670-1vlowf2n	113	12	S	s	NN
cord-288670-1vlowf2n	113	13	protein	protein	NN
cord-288670-1vlowf2n	113	14	)	)	-RRB-
cord-288670-1vlowf2n	113	15	by	by	IN
cord-288670-1vlowf2n	113	16	proteases	protease	NNS
cord-288670-1vlowf2n	113	17	is	be	VBZ
cord-288670-1vlowf2n	113	18	required	require	VBN
cord-288670-1vlowf2n	113	19	for	for	IN
cord-288670-1vlowf2n	113	20	the	the	DT
cord-288670-1vlowf2n	113	21	SARS	SARS	NNP
cord-288670-1vlowf2n	113	22	-	-	HYPH
cord-288670-1vlowf2n	113	23	CoV	CoV	NNP
cord-288670-1vlowf2n	113	24	entry	entry	NN
cord-288670-1vlowf2n	113	25	to	to	IN
cord-288670-1vlowf2n	113	26	the	the	DT
cord-288670-1vlowf2n	113	27	cells	cell	NNS
cord-288670-1vlowf2n	113	28	via	via	IN
cord-288670-1vlowf2n	113	29	a	a	DT
cord-288670-1vlowf2n	113	30	pH	ph	NN
cord-288670-1vlowf2n	113	31	-	-	HYPH
cord-288670-1vlowf2n	113	32	dependent	dependent	JJ
cord-288670-1vlowf2n	113	33	manner	manner	NN
cord-288670-1vlowf2n	113	34	[	[	-LRB-
cord-288670-1vlowf2n	113	35	45	45	CD
cord-288670-1vlowf2n	113	36	]	]	-RRB-
cord-288670-1vlowf2n	113	37	.	.	.
cord-288670-1vlowf2n	114	1	Mechanistically	Mechanistically	NNP
cord-288670-1vlowf2n	114	2	,	,	,
cord-288670-1vlowf2n	114	3	it	-PRON-	PRP
cord-288670-1vlowf2n	114	4	is	be	VBZ
cord-288670-1vlowf2n	114	5	believed	believe	VBN
cord-288670-1vlowf2n	114	6	that	that	IN
cord-288670-1vlowf2n	114	7	the	the	DT
cord-288670-1vlowf2n	114	8	neutralization	neutralization	NN
cord-288670-1vlowf2n	114	9	of	of	IN
cord-288670-1vlowf2n	114	10	endo	endo	NN
cord-288670-1vlowf2n	114	11	-	-	HYPH
cord-288670-1vlowf2n	114	12	lysosomal	lysosomal	JJ
cord-288670-1vlowf2n	114	13	pH	ph	NN
cord-288670-1vlowf2n	114	14	by	by	IN
cord-288670-1vlowf2n	114	15	CQ	CQ	NNP
cord-288670-1vlowf2n	114	16	inhibits	inhibit	VBZ
cord-288670-1vlowf2n	114	17	the	the	DT
cord-288670-1vlowf2n	114	18	protease	protease	NN
cord-288670-1vlowf2n	114	19	activities	activity	NNS
cord-288670-1vlowf2n	114	20	and	and	CC
cord-288670-1vlowf2n	114	21	prevents	prevent	VBZ
cord-288670-1vlowf2n	114	22	the	the	DT
cord-288670-1vlowf2n	114	23	cleavage	cleavage	NN
cord-288670-1vlowf2n	114	24	of	of	IN
cord-288670-1vlowf2n	114	25	S	s	NN
cord-288670-1vlowf2n	114	26	protein	protein	NN
cord-288670-1vlowf2n	114	27	and	and	CC
cord-288670-1vlowf2n	114	28	subsequently	subsequently	RB
cord-288670-1vlowf2n	114	29	impairs	impair	VBZ
cord-288670-1vlowf2n	114	30	the	the	DT
cord-288670-1vlowf2n	114	31	viral	viral	JJ
cord-288670-1vlowf2n	114	32	entry	entry	NN
cord-288670-1vlowf2n	114	33	into	into	IN
cord-288670-1vlowf2n	114	34	the	the	DT
cord-288670-1vlowf2n	114	35	host	host	NN
cord-288670-1vlowf2n	114	36	cell	cell	NN
cord-288670-1vlowf2n	114	37	.	.	.
cord-288670-1vlowf2n	115	1	Interestingly	interestingly	RB
cord-288670-1vlowf2n	115	2	,	,	,
cord-288670-1vlowf2n	115	3	Wang	Wang	NNP
cord-288670-1vlowf2n	115	4	et	et	NNP
cord-288670-1vlowf2n	115	5	al	al	NNP
cord-288670-1vlowf2n	115	6	showed	show	VBD
cord-288670-1vlowf2n	115	7	that	that	IN
cord-288670-1vlowf2n	115	8	in	in	IN
cord-288670-1vlowf2n	115	9	cells	cell	NNS
cord-288670-1vlowf2n	115	10	treated	treat	VBN
cord-288670-1vlowf2n	115	11	with	with	IN
cord-288670-1vlowf2n	115	12	CQ	CQ	NNP
cord-288670-1vlowf2n	115	13	,	,	,
cord-288670-1vlowf2n	115	14	NH4Cl	NH4Cl	NNP
cord-288670-1vlowf2n	115	15	or	or	CC
cord-288670-1vlowf2n	115	16	Bafilomycin	Bafilomycin	NNP
cord-288670-1vlowf2n	115	17	A1	A1	NNP
cord-288670-1vlowf2n	115	18	(	(	-LRB-
cord-288670-1vlowf2n	115	19	an	an	DT
cord-288670-1vlowf2n	115	20	endo	endo	NN
cord-288670-1vlowf2n	115	21	/	/	SYM
cord-288670-1vlowf2n	115	22	lysosomal	lysosomal	JJ
cord-288670-1vlowf2n	115	23	V	v	NN
cord-288670-1vlowf2n	115	24	-	-	HYPH
cord-288670-1vlowf2n	115	25	ATPase	ATPase	NNP
cord-288670-1vlowf2n	115	26	inhibitor	inhibitor	NN
cord-288670-1vlowf2n	115	27	)	)	-RRB-
cord-288670-1vlowf2n	115	28	,	,	,
cord-288670-1vlowf2n	115	29	the	the	DT
cord-288670-1vlowf2n	115	30	viral	viral	JJ
cord-288670-1vlowf2n	115	31	receptor	receptor	NN
cord-288670-1vlowf2n	115	32	ACE2	ACE2	NNP
cord-288670-1vlowf2n	115	33	was	be	VBD
cord-288670-1vlowf2n	115	34	trapped	trap	VBN
cord-288670-1vlowf2n	115	35	within	within	IN
cord-288670-1vlowf2n	115	36	perinuclear	perinuclear	NN
cord-288670-1vlowf2n	115	37	vacuoles	vacuole	NNS
cord-288670-1vlowf2n	115	38	[	[	-LRB-
cord-288670-1vlowf2n	115	39	38	38	CD
cord-288670-1vlowf2n	115	40	]	]	-RRB-
cord-288670-1vlowf2n	115	41	,	,	,
cord-288670-1vlowf2n	115	42	suggesting	suggest	VBG
cord-288670-1vlowf2n	115	43	that	that	IN
cord-288670-1vlowf2n	115	44	these	these	DT
cord-288670-1vlowf2n	115	45	lysosomotropic	lysosomotropic	JJ
cord-288670-1vlowf2n	115	46	agents	agent	NNS
cord-288670-1vlowf2n	115	47	may	may	MD
cord-288670-1vlowf2n	115	48	also	also	RB
cord-288670-1vlowf2n	115	49	affect	affect	VB
cord-288670-1vlowf2n	115	50	the	the	DT
cord-288670-1vlowf2n	115	51	function	function	NN
cord-288670-1vlowf2n	115	52	of	of	IN
cord-288670-1vlowf2n	115	53	ACE2	ACE2	NNP
cord-288670-1vlowf2n	115	54	.	.	.
cord-288670-1vlowf2n	116	1	Since	since	IN
cord-288670-1vlowf2n	116	2	ACE2	ACE2	NNP
cord-288670-1vlowf2n	116	3	serves	serve	VBZ
cord-288670-1vlowf2n	116	4	as	as	IN
cord-288670-1vlowf2n	116	5	the	the	DT
cord-288670-1vlowf2n	116	6	viral	viral	JJ
cord-288670-1vlowf2n	116	7	receptor	receptor	NN
cord-288670-1vlowf2n	116	8	for	for	IN
cord-288670-1vlowf2n	116	9	both	both	DT
cord-288670-1vlowf2n	116	10	SARS	SARS	NNP
cord-288670-1vlowf2n	116	11	-	-	HYPH
cord-288670-1vlowf2n	116	12	CoV	CoV	NNP
cord-288670-1vlowf2n	116	13	and	and	CC
cord-288670-1vlowf2n	116	14	SARS	SARS	NNP
cord-288670-1vlowf2n	116	15	-	-	HYPH
cord-288670-1vlowf2n	116	16	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	116	17	,	,	,
cord-288670-1vlowf2n	116	18	such	such	JJ
cord-288670-1vlowf2n	116	19	observations	observation	NNS
cord-288670-1vlowf2n	116	20	further	far	RBR
cord-288670-1vlowf2n	116	21	support	support	VBP
cord-288670-1vlowf2n	116	22	the	the	DT
cord-288670-1vlowf2n	116	23	notion	notion	NN
cord-288670-1vlowf2n	116	24	for	for	IN
cord-288670-1vlowf2n	116	25	the	the	DT
cord-288670-1vlowf2n	116	26	potent	potent	JJ
cord-288670-1vlowf2n	116	27	anti	anti	JJ
cord-288670-1vlowf2n	116	28	-	-	JJ
cord-288670-1vlowf2n	116	29	viral	viral	JJ
cord-288670-1vlowf2n	116	30	activity	activity	NN
cord-288670-1vlowf2n	116	31	of	of	IN
cord-288670-1vlowf2n	116	32	those	those	DT
cord-288670-1vlowf2n	116	33	lysosomotropic	lysosomotropic	JJ
cord-288670-1vlowf2n	116	34	agents	agent	NNS
cord-288670-1vlowf2n	116	35	.	.	.
cord-288670-1vlowf2n	117	1	Indeed	indeed	RB
cord-288670-1vlowf2n	117	2	,	,	,
cord-288670-1vlowf2n	117	3	a	a	DT
cord-288670-1vlowf2n	117	4	very	very	RB
cord-288670-1vlowf2n	117	5	recent	recent	JJ
cord-288670-1vlowf2n	117	6	study	study	NN
cord-288670-1vlowf2n	117	7	showed	show	VBD
cord-288670-1vlowf2n	117	8	that	that	IN
cord-288670-1vlowf2n	117	9	CQ	CQ	NNP
cord-288670-1vlowf2n	117	10	inhibits	inhibit	VBZ
cord-288670-1vlowf2n	117	11	the	the	DT
cord-288670-1vlowf2n	117	12	SARS	SARS	NNP
cord-288670-1vlowf2n	117	13	-	-	HYPH
cord-288670-1vlowf2n	117	14	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	117	15	infection	infection	NN
cord-288670-1vlowf2n	117	16	at	at	IN
cord-288670-1vlowf2n	117	17	both	both	DT
cord-288670-1vlowf2n	117	18	entry	entry	NN
cord-288670-1vlowf2n	117	19	and	and	CC
cord-288670-1vlowf2n	117	20	post	post	JJ
cord-288670-1vlowf2n	117	21	-	-	JJ
cord-288670-1vlowf2n	117	22	entry	entry	JJ
cord-288670-1vlowf2n	117	23	stages	stage	NNS
cord-288670-1vlowf2n	117	24	in	in	IN
cord-288670-1vlowf2n	117	25	Vero	Vero	NNP
cord-288670-1vlowf2n	117	26	E6	E6	NNP
cord-288670-1vlowf2n	117	27	cells	cell	NNS
cord-288670-1vlowf2n	117	28	[	[	-LRB-
cord-288670-1vlowf2n	117	29	43	43	CD
cord-288670-1vlowf2n	117	30	]	]	-RRB-
cord-288670-1vlowf2n	117	31	.	.	.
cord-288670-1vlowf2n	118	1	In	in	IN
cord-288670-1vlowf2n	118	2	addition	addition	NN
cord-288670-1vlowf2n	118	3	to	to	IN
cord-288670-1vlowf2n	118	4	its	-PRON-	PRP$
cord-288670-1vlowf2n	118	5	direct	direct	JJ
cord-288670-1vlowf2n	118	6	effects	effect	NNS
cord-288670-1vlowf2n	118	7	on	on	IN
cord-288670-1vlowf2n	118	8	CoVs	CoVs	NNP
cord-288670-1vlowf2n	118	9	,	,	,
cord-288670-1vlowf2n	118	10	there	there	EX
cord-288670-1vlowf2n	118	11	is	be	VBZ
cord-288670-1vlowf2n	118	12	evidence	evidence	NN
cord-288670-1vlowf2n	118	13	of	of	IN
cord-288670-1vlowf2n	118	14	the	the	DT
cord-288670-1vlowf2n	118	15	combinational	combinational	JJ
cord-288670-1vlowf2n	118	16	activity	activity	NN
cord-288670-1vlowf2n	118	17	of	of	IN
cord-288670-1vlowf2n	118	18	CQ	CQ	NNP
cord-288670-1vlowf2n	118	19	with	with	IN
cord-288670-1vlowf2n	118	20	other	other	JJ
cord-288670-1vlowf2n	118	21	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	118	22	agents	agent	NNS
cord-288670-1vlowf2n	118	23	for	for	IN
cord-288670-1vlowf2n	118	24	treatment	treatment	NN
cord-288670-1vlowf2n	118	25	of	of	IN
cord-288670-1vlowf2n	118	26	SARS	SARS	NNP
cord-288670-1vlowf2n	118	27	,	,	,
cord-288670-1vlowf2n	118	28	MERS	MERS	NNP
cord-288670-1vlowf2n	118	29	and	and	CC
cord-288670-1vlowf2n	118	30	possibly	possibly	RB
cord-288670-1vlowf2n	118	31	COVID-19	covid-19	VB
cord-288670-1vlowf2n	118	32	.	.	.
cord-288670-1vlowf2n	119	1	For	for	IN
cord-288670-1vlowf2n	119	2	instance	instance	NN
cord-288670-1vlowf2n	119	3	,	,	,
cord-288670-1vlowf2n	119	4	He	-PRON-	PRP
cord-288670-1vlowf2n	119	5	et	et	FW
cord-288670-1vlowf2n	119	6	al	al	NNP
cord-288670-1vlowf2n	119	7	reported	report	VBD
cord-288670-1vlowf2n	119	8	that	that	IN
cord-288670-1vlowf2n	119	9	CQ	CQ	NNP
cord-288670-1vlowf2n	119	10	has	have	VBZ
cord-288670-1vlowf2n	119	11	synergistic	synergistic	JJ
cord-288670-1vlowf2n	119	12	effect	effect	NN
cord-288670-1vlowf2n	119	13	on	on	IN
cord-288670-1vlowf2n	119	14	glucocorticoid	glucocorticoid	NN
cord-288670-1vlowf2n	119	15	signaling	signal	VBG
cord-288670-1vlowf2n	119	16	by	by	IN
cord-288670-1vlowf2n	119	17	stabilizing	stabilize	VBG
cord-288670-1vlowf2n	119	18	glucocorticoid	glucocorticoid	NN
cord-288670-1vlowf2n	119	19	receptor	receptor	NN
cord-288670-1vlowf2n	119	20	[	[	-LRB-
cord-288670-1vlowf2n	119	21	61	61	CD
cord-288670-1vlowf2n	119	22	]	]	-RRB-
cord-288670-1vlowf2n	119	23	.	.	.
cord-288670-1vlowf2n	120	1	Since	since	IN
cord-288670-1vlowf2n	120	2	glucocorticoid	glucocorticoid	NN
cord-288670-1vlowf2n	120	3	is	be	VBZ
cord-288670-1vlowf2n	120	4	one	one	CD
cord-288670-1vlowf2n	120	5	of	of	IN
cord-288670-1vlowf2n	120	6	the	the	DT
cord-288670-1vlowf2n	120	7	recommended	recommend	VBN
cord-288670-1vlowf2n	120	8	therapy	therapy	NN
cord-288670-1vlowf2n	120	9	for	for	IN
cord-288670-1vlowf2n	120	10	severe	severe	JJ
cord-288670-1vlowf2n	120	11	SARS	SARS	NNP
cord-288670-1vlowf2n	120	12	patients	patient	NNS
cord-288670-1vlowf2n	120	13	[	[	-LRB-
cord-288670-1vlowf2n	120	14	62	62	CD
cord-288670-1vlowf2n	120	15	]	]	-RRB-
cord-288670-1vlowf2n	120	16	,	,	,
cord-288670-1vlowf2n	120	17	it	-PRON-	PRP
cord-288670-1vlowf2n	120	18	is	be	VBZ
cord-288670-1vlowf2n	120	19	possible	possible	JJ
cord-288670-1vlowf2n	120	20	that	that	IN
cord-288670-1vlowf2n	120	21	CQ	CQ	NNP
cord-288670-1vlowf2n	120	22	may	may	MD
cord-288670-1vlowf2n	120	23	can	can	MD
cord-288670-1vlowf2n	120	24	be	be	VB
cord-288670-1vlowf2n	120	25	used	use	VBN
cord-288670-1vlowf2n	120	26	for	for	IN
cord-288670-1vlowf2n	120	27	treatment	treatment	NN
cord-288670-1vlowf2n	120	28	of	of	IN
cord-288670-1vlowf2n	120	29	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	120	30	in	in	IN
cord-288670-1vlowf2n	120	31	combination	combination	NN
cord-288670-1vlowf2n	120	32	of	of	IN
cord-288670-1vlowf2n	120	33	glucocorticoids	glucocorticoid	NNS
cord-288670-1vlowf2n	120	34	and	and	CC
cord-288670-1vlowf2n	120	35	clinical	clinical	JJ
cord-288670-1vlowf2n	120	36	trials	trial	NNS
cord-288670-1vlowf2n	120	37	are	be	VBP
cord-288670-1vlowf2n	120	38	thus	thus	RB
cord-288670-1vlowf2n	120	39	needed	need	VBN
cord-288670-1vlowf2n	120	40	to	to	TO
cord-288670-1vlowf2n	120	41	test	test	VB
cord-288670-1vlowf2n	120	42	the	the	DT
cord-288670-1vlowf2n	120	43	efficacy	efficacy	NN
cord-288670-1vlowf2n	120	44	of	of	IN
cord-288670-1vlowf2n	120	45	such	such	JJ
cord-288670-1vlowf2n	120	46	combined	combine	VBN
cord-288670-1vlowf2n	120	47	therapy	therapy	NN
cord-288670-1vlowf2n	120	48	.	.	.
cord-288670-1vlowf2n	121	1	At	at	IN
cord-288670-1vlowf2n	121	2	present	present	NN
cord-288670-1vlowf2n	121	3	,	,	,
cord-288670-1vlowf2n	121	4	CQ	CQ	NNP
cord-288670-1vlowf2n	121	5	phosphate	phosphate	NN
cord-288670-1vlowf2n	121	6	has	have	VBZ
cord-288670-1vlowf2n	121	7	been	be	VBN
cord-288670-1vlowf2n	121	8	listed	list	VBN
cord-288670-1vlowf2n	121	9	as	as	IN
cord-288670-1vlowf2n	121	10	a	a	DT
cord-288670-1vlowf2n	121	11	new	new	JJ
cord-288670-1vlowf2n	121	12	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	121	13	in	in	IN
cord-288670-1vlowf2n	121	14	the	the	DT
cord-288670-1vlowf2n	121	15	sixth	sixth	JJ
cord-288670-1vlowf2n	121	16	version	version	NN
cord-288670-1vlowf2n	121	17	of	of	IN
cord-288670-1vlowf2n	121	18	"	"	``
cord-288670-1vlowf2n	121	19	Guidelines	Guidelines	NNPS
cord-288670-1vlowf2n	121	20	for	for	IN
cord-288670-1vlowf2n	121	21	the	the	DT
cord-288670-1vlowf2n	121	22	Prevention	Prevention	NNP
cord-288670-1vlowf2n	121	23	,	,	,
cord-288670-1vlowf2n	121	24	Diagnosis	Diagnosis	NNP
cord-288670-1vlowf2n	121	25	,	,	,
cord-288670-1vlowf2n	121	26	and	and	CC
cord-288670-1vlowf2n	121	27	Treatment	Treatment	NNP
cord-288670-1vlowf2n	121	28	of	of	IN
cord-288670-1vlowf2n	121	29	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	121	30	"	"	''
cord-288670-1vlowf2n	121	31	issued	issue	VBN
cord-288670-1vlowf2n	121	32	by	by	IN
cord-288670-1vlowf2n	121	33	the	the	DT
cord-288670-1vlowf2n	121	34	National	National	NNP
cord-288670-1vlowf2n	121	35	Health	Health	NNP
cord-288670-1vlowf2n	121	36	Commission	Commission	NNP
cord-288670-1vlowf2n	121	37	of	of	IN
cord-288670-1vlowf2n	121	38	the	the	DT
cord-288670-1vlowf2n	121	39	People	People	NNPS
cord-288670-1vlowf2n	121	40	's	's	POS
cord-288670-1vlowf2n	121	41	Republic	Republic	NNP
cord-288670-1vlowf2n	121	42	of	of	IN
cord-288670-1vlowf2n	121	43	China	China	NNP
cord-288670-1vlowf2n	121	44	.	.	.
cord-288670-1vlowf2n	122	1	And	and	CC
cord-288670-1vlowf2n	122	2	a	a	DT
cord-288670-1vlowf2n	122	3	number	number	NN
cord-288670-1vlowf2n	122	4	of	of	IN
cord-288670-1vlowf2n	122	5	clinical	clinical	JJ
cord-288670-1vlowf2n	122	6	trials	trial	NNS
cord-288670-1vlowf2n	122	7	with	with	IN
cord-288670-1vlowf2n	122	8	CQ	CQ	NNP
cord-288670-1vlowf2n	122	9	have	have	VBP
cord-288670-1vlowf2n	122	10	been	be	VBN
cord-288670-1vlowf2n	122	11	initiated	initiate	VBN
cord-288670-1vlowf2n	122	12	in	in	IN
cord-288670-1vlowf2n	122	13	China	China	NNP
cord-288670-1vlowf2n	122	14	[	[	-LRB-
cord-288670-1vlowf2n	122	15	63	63	CD
cord-288670-1vlowf2n	122	16	]	]	-RRB-
cord-288670-1vlowf2n	122	17	.	.	.
cord-288670-1vlowf2n	123	1	The	the	DT
cord-288670-1vlowf2n	123	2	current	current	JJ
cord-288670-1vlowf2n	123	3	suggested	suggest	VBD
cord-288670-1vlowf2n	123	4	dosage	dosage	NN
cord-288670-1vlowf2n	123	5	of	of	IN
cord-288670-1vlowf2n	123	6	CQ	CQ	NNP
cord-288670-1vlowf2n	123	7	for	for	IN
cord-288670-1vlowf2n	123	8	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	123	9	is	be	VBZ
cord-288670-1vlowf2n	123	10	as	as	RB
cord-288670-1vlowf2n	123	11	high	high	JJ
cord-288670-1vlowf2n	123	12	as	as	IN
cord-288670-1vlowf2n	123	13	500	500	CD
cord-288670-1vlowf2n	123	14	mg	mg	NNP
cord-288670-1vlowf2n	123	15	,	,	,
cord-288670-1vlowf2n	123	16	with	with	IN
cord-288670-1vlowf2n	123	17	treatment	treatment	NN
cord-288670-1vlowf2n	123	18	not	not	RB
cord-288670-1vlowf2n	123	19	exceeding	exceed	VBG
cord-288670-1vlowf2n	123	20	10	10	CD
cord-288670-1vlowf2n	123	21	days	day	NNS
cord-288670-1vlowf2n	123	22	.	.	.
cord-288670-1vlowf2n	124	1	However	however	RB
cord-288670-1vlowf2n	124	2	,	,	,
cord-288670-1vlowf2n	124	3	the	the	DT
cord-288670-1vlowf2n	124	4	usage	usage	NN
cord-288670-1vlowf2n	124	5	of	of	IN
cord-288670-1vlowf2n	124	6	CQ	CQ	NNP
cord-288670-1vlowf2n	124	7	phosphate	phosphate	NN
cord-288670-1vlowf2n	124	8	should	should	MD
cord-288670-1vlowf2n	124	9	be	be	VB
cord-288670-1vlowf2n	124	10	evaluated	evaluate	VBN
cord-288670-1vlowf2n	124	11	carefully	carefully	RB
cord-288670-1vlowf2n	124	12	as	as	IN
cord-288670-1vlowf2n	124	13	it	-PRON-	PRP
cord-288670-1vlowf2n	124	14	may	may	MD
cord-288670-1vlowf2n	124	15	also	also	RB
cord-288670-1vlowf2n	124	16	have	have	VB
cord-288670-1vlowf2n	124	17	side	side	NN
cord-288670-1vlowf2n	124	18	effects	effect	NNS
cord-288670-1vlowf2n	124	19	such	such	JJ
cord-288670-1vlowf2n	124	20	as	as	IN
cord-288670-1vlowf2n	124	21	retinopathy	retinopathy	NN
cord-288670-1vlowf2n	124	22	[	[	-LRB-
cord-288670-1vlowf2n	124	23	64	64	CD
cord-288670-1vlowf2n	124	24	]	]	-RRB-
cord-288670-1vlowf2n	124	25	and	and	CC
cord-288670-1vlowf2n	124	26	cautions	caution	NNS
cord-288670-1vlowf2n	124	27	should	should	MD
cord-288670-1vlowf2n	124	28	be	be	VB
cord-288670-1vlowf2n	124	29	taken	take	VBN
cord-288670-1vlowf2n	124	30	for	for	IN
cord-288670-1vlowf2n	124	31	close	close	JJ
cord-288670-1vlowf2n	124	32	monitoring	monitoring	NN
cord-288670-1vlowf2n	124	33	of	of	IN
cord-288670-1vlowf2n	124	34	the	the	DT
cord-288670-1vlowf2n	124	35	potential	potential	JJ
cord-288670-1vlowf2n	124	36	side	side	NN
cord-288670-1vlowf2n	124	37	effect	effect	NN
cord-288670-1vlowf2n	124	38	throughout	throughout	IN
cord-288670-1vlowf2n	124	39	the	the	DT
cord-288670-1vlowf2n	124	40	whole	whole	JJ
cord-288670-1vlowf2n	124	41	treatment	treatment	NN
cord-288670-1vlowf2n	124	42	period	period	NN
cord-288670-1vlowf2n	124	43	.	.	.
cord-288670-1vlowf2n	125	1	The	the	DT
cord-288670-1vlowf2n	125	2	dosage	dosage	NN
cord-288670-1vlowf2n	125	3	should	should	MD
cord-288670-1vlowf2n	125	4	be	be	VB
cord-288670-1vlowf2n	125	5	reduced	reduce	VBN
cord-288670-1vlowf2n	125	6	or	or	CC
cord-288670-1vlowf2n	125	7	stopped	stop	VBN
cord-288670-1vlowf2n	125	8	if	if	IN
cord-288670-1vlowf2n	125	9	reduction	reduction	NN
cord-288670-1vlowf2n	125	10	in	in	IN
cord-288670-1vlowf2n	125	11	haemoglobin	haemoglobin	NN
cord-288670-1vlowf2n	125	12	concentration	concentration	NN
cord-288670-1vlowf2n	125	13	,	,	,
cord-288670-1vlowf2n	125	14	lymphocyte	lymphocyte	NN
cord-288670-1vlowf2n	125	15	count	count	NN
cord-288670-1vlowf2n	125	16	and	and	CC
cord-288670-1vlowf2n	125	17	platelet	platelet	NN
cord-288670-1vlowf2n	125	18	count	count	NN
cord-288670-1vlowf2n	125	19	,	,	,
cord-288670-1vlowf2n	125	20	or	or	CC
cord-288670-1vlowf2n	125	21	the	the	DT
cord-288670-1vlowf2n	125	22	eyesight	eyesight	NN
cord-288670-1vlowf2n	125	23	are	be	VBP
cord-288670-1vlowf2n	125	24	observed	observe	VBN
cord-288670-1vlowf2n	125	25	.	.	.
cord-288670-1vlowf2n	126	1	In	in	IN
cord-288670-1vlowf2n	126	2	addition	addition	NN
cord-288670-1vlowf2n	126	3	,	,	,
cord-288670-1vlowf2n	126	4	since	since	IN
cord-288670-1vlowf2n	126	5	CQ	CQ	NNP
cord-288670-1vlowf2n	126	6	is	be	VBZ
cord-288670-1vlowf2n	126	7	the	the	DT
cord-288670-1vlowf2n	126	8	substrate	substrate	NN
cord-288670-1vlowf2n	126	9	of	of	IN
cord-288670-1vlowf2n	126	10	cytochrome	cytochrome	NN
cord-288670-1vlowf2n	126	11	P450	p450	NN
cord-288670-1vlowf2n	126	12	(	(	-LRB-
cord-288670-1vlowf2n	126	13	CYP	CYP	NNP
cord-288670-1vlowf2n	126	14	)	)	-RRB-
cord-288670-1vlowf2n	126	15	enzymes	enzyme	NNS
cord-288670-1vlowf2n	126	16	which	which	WDT
cord-288670-1vlowf2n	126	17	are	be	VBP
cord-288670-1vlowf2n	126	18	responsible	responsible	JJ
cord-288670-1vlowf2n	126	19	for	for	IN
cord-288670-1vlowf2n	126	20	the	the	DT
cord-288670-1vlowf2n	126	21	metabolism	metabolism	NN
cord-288670-1vlowf2n	126	22	of	of	IN
cord-288670-1vlowf2n	126	23	multiple	multiple	JJ
cord-288670-1vlowf2n	126	24	drugs	drug	NNS
cord-288670-1vlowf2n	126	25	,	,	,
cord-288670-1vlowf2n	126	26	it	-PRON-	PRP
cord-288670-1vlowf2n	126	27	might	may	MD
cord-288670-1vlowf2n	126	28	interfere	interfere	VB
cord-288670-1vlowf2n	126	29	with	with	IN
cord-288670-1vlowf2n	126	30	other	other	JJ
cord-288670-1vlowf2n	126	31	medications	medication	NNS
cord-288670-1vlowf2n	126	32	such	such	JJ
cord-288670-1vlowf2n	126	33	as	as	IN
cord-288670-1vlowf2n	126	34	digitoxin	digitoxin	NNP
cord-288670-1vlowf2n	126	35	(	(	-LRB-
cord-288670-1vlowf2n	126	36	a	a	DT
cord-288670-1vlowf2n	126	37	cardiac	cardiac	JJ
cord-288670-1vlowf2n	126	38	glycoside	glycoside	NN
cord-288670-1vlowf2n	126	39	)	)	-RRB-
cord-288670-1vlowf2n	126	40	and	and	CC
cord-288670-1vlowf2n	126	41	tamoxifen	tamoxifen	NNP
cord-288670-1vlowf2n	126	42	(	(	-LRB-
cord-288670-1vlowf2n	126	43	used	use	VBN
cord-288670-1vlowf2n	126	44	for	for	IN
cord-288670-1vlowf2n	126	45	treatment	treatment	NN
cord-288670-1vlowf2n	126	46	of	of	IN
cord-288670-1vlowf2n	126	47	breast	breast	NN
cord-288670-1vlowf2n	126	48	cancer	cancer	NN
cord-288670-1vlowf2n	126	49	)	)	-RRB-
cord-288670-1vlowf2n	126	50	.	.	.
cord-288670-1vlowf2n	127	1	More	More	JJR
cord-288670-1vlowf2n	127	2	details	detail	NNS
cord-288670-1vlowf2n	127	3	of	of	IN
cord-288670-1vlowf2n	127	4	the	the	DT
cord-288670-1vlowf2n	127	5	toxicity	toxicity	NN
cord-288670-1vlowf2n	127	6	and	and	CC
cord-288670-1vlowf2n	127	7	precautious	precautious	JJ
cord-288670-1vlowf2n	127	8	of	of	IN
cord-288670-1vlowf2n	127	9	CQ	CQ	NNP
cord-288670-1vlowf2n	127	10	can	can	MD
cord-288670-1vlowf2n	127	11	be	be	VB
cord-288670-1vlowf2n	127	12	referred	refer	VBN
cord-288670-1vlowf2n	127	13	elsewhere	elsewhere	RB
cord-288670-1vlowf2n	127	14	[	[	-LRB-
cord-288670-1vlowf2n	127	15	65	65	CD
cord-288670-1vlowf2n	127	16	]	]	-RRB-
cord-288670-1vlowf2n	127	17	.	.	.
cord-288670-1vlowf2n	128	1	Cathepsins	cathepsin	NNS
cord-288670-1vlowf2n	128	2	are	be	VBP
cord-288670-1vlowf2n	128	3	endosomal	endosomal	JJ
cord-288670-1vlowf2n	128	4	and	and	CC
cord-288670-1vlowf2n	128	5	lysosomal	lysosomal	JJ
cord-288670-1vlowf2n	128	6	cysteine	cysteine	NN
cord-288670-1vlowf2n	128	7	proteases	protease	NNS
cord-288670-1vlowf2n	128	8	that	that	WDT
cord-288670-1vlowf2n	128	9	play	play	VBP
cord-288670-1vlowf2n	128	10	important	important	JJ
cord-288670-1vlowf2n	128	11	roles	role	NNS
cord-288670-1vlowf2n	128	12	in	in	IN
cord-288670-1vlowf2n	128	13	protein	protein	NN
cord-288670-1vlowf2n	128	14	degradation	degradation	NN
cord-288670-1vlowf2n	128	15	in	in	IN
cord-288670-1vlowf2n	128	16	various	various	JJ
cord-288670-1vlowf2n	128	17	cellular	cellular	JJ
cord-288670-1vlowf2n	128	18	processes	process	NNS
cord-288670-1vlowf2n	128	19	including	include	VBG
cord-288670-1vlowf2n	128	20	both	both	CC
cord-288670-1vlowf2n	128	21	the	the	DT
cord-288670-1vlowf2n	128	22	endocytic	endocytic	JJ
cord-288670-1vlowf2n	128	23	pathway	pathway	NN
cord-288670-1vlowf2n	128	24	and	and	CC
cord-288670-1vlowf2n	128	25	autophagy	autophagy	NN
cord-288670-1vlowf2n	128	26	[	[	-LRB-
cord-288670-1vlowf2n	128	27	64	64	CD
cord-288670-1vlowf2n	128	28	]	]	-RRB-
cord-288670-1vlowf2n	128	29	.	.	.
cord-288670-1vlowf2n	129	1	The	the	DT
cord-288670-1vlowf2n	129	2	role	role	NN
cord-288670-1vlowf2n	129	3	of	of	IN
cord-288670-1vlowf2n	129	4	cathepsins	cathepsin	NNS
cord-288670-1vlowf2n	129	5	in	in	IN
cord-288670-1vlowf2n	129	6	viral	viral	JJ
cord-288670-1vlowf2n	129	7	infection	infection	NN
cord-288670-1vlowf2n	129	8	was	be	VBD
cord-288670-1vlowf2n	129	9	first	first	RB
cord-288670-1vlowf2n	129	10	identified	identify	VBN
cord-288670-1vlowf2n	129	11	by	by	IN
cord-288670-1vlowf2n	129	12	Huang	Huang	NNP
cord-288670-1vlowf2n	129	13	et	et	NNP
cord-288670-1vlowf2n	129	14	al	al	NNP
cord-288670-1vlowf2n	130	1	and	and	CC
cord-288670-1vlowf2n	130	2	they	-PRON-	PRP
cord-288670-1vlowf2n	130	3	found	find	VBD
cord-288670-1vlowf2n	130	4	that	that	IN
cord-288670-1vlowf2n	130	5	one	one	CD
cord-288670-1vlowf2n	130	6	cysteine	cysteine	NN
cord-288670-1vlowf2n	130	7	proteases	protease	NNS
cord-288670-1vlowf2n	130	8	inhibitor	inhibitor	NN
cord-288670-1vlowf2n	130	9	E64d	E64d	NNS
cord-288670-1vlowf2n	130	10	and	and	CC
cord-288670-1vlowf2n	130	11	a	a	DT
cord-288670-1vlowf2n	130	12	specific	specific	JJ
cord-288670-1vlowf2n	130	13	cathepsin	cathepsin	NN
cord-288670-1vlowf2n	131	1	L	L	NNP
cord-288670-1vlowf2n	131	2	inhibitor	inhibitor	NN
cord-288670-1vlowf2n	131	3	Z	Z	NNP
cord-288670-1vlowf2n	131	4	-	-	HYPH
cord-288670-1vlowf2n	131	5	FY(t	FY(t	NNP
cord-288670-1vlowf2n	131	6	-	-	HYPH
cord-288670-1vlowf2n	131	7	Bu)-DMK	Bu)-DMK	NNP
cord-288670-1vlowf2n	131	8	are	be	VBP
cord-288670-1vlowf2n	131	9	able	able	JJ
cord-288670-1vlowf2n	131	10	to	to	TO
cord-288670-1vlowf2n	131	11	block	block	VB
cord-288670-1vlowf2n	131	12	the	the	DT
cord-288670-1vlowf2n	131	13	SARS	SARS	NNP
cord-288670-1vlowf2n	131	14	-	-	HYPH
cord-288670-1vlowf2n	131	15	CoV	CoV	NNP
cord-288670-1vlowf2n	131	16	infection	infection	NN
cord-288670-1vlowf2n	131	17	[	[	-LRB-
cord-288670-1vlowf2n	131	18	48	48	CD
cord-288670-1vlowf2n	131	19	]	]	-RRB-
cord-288670-1vlowf2n	131	20	.	.	.
cord-288670-1vlowf2n	132	1	K11777	K11777	NNP
cord-288670-1vlowf2n	132	2	is	be	VBZ
cord-288670-1vlowf2n	132	3	another	another	DT
cord-288670-1vlowf2n	132	4	cysteine	cysteine	NN
cord-288670-1vlowf2n	132	5	protease	protease	NN
cord-288670-1vlowf2n	132	6	inhibitor	inhibitor	NN
cord-288670-1vlowf2n	132	7	that	that	WDT
cord-288670-1vlowf2n	132	8	has	have	VBZ
cord-288670-1vlowf2n	132	9	been	be	VBN
cord-288670-1vlowf2n	132	10	reported	report	VBN
cord-288670-1vlowf2n	132	11	to	to	TO
cord-288670-1vlowf2n	132	12	block	block	VB
cord-288670-1vlowf2n	132	13	the	the	DT
cord-288670-1vlowf2n	132	14	entry	entry	NN
cord-288670-1vlowf2n	132	15	of	of	IN
cord-288670-1vlowf2n	132	16	SARS	SARS	NNP
cord-288670-1vlowf2n	132	17	-	-	HYPH
cord-288670-1vlowf2n	132	18	CoV	CoV	NNP
cord-288670-1vlowf2n	132	19	at	at	IN
cord-288670-1vlowf2n	132	20	the	the	DT
cord-288670-1vlowf2n	132	21	sub	sub	JJ
cord-288670-1vlowf2n	132	22	-	-	JJ
cord-288670-1vlowf2n	132	23	nanomolar	nanomolar	JJ
cord-288670-1vlowf2n	132	24	range	range	NN
cord-288670-1vlowf2n	132	25	[	[	-LRB-
cord-288670-1vlowf2n	132	26	66	66	CD
cord-288670-1vlowf2n	132	27	]	]	-RRB-
cord-288670-1vlowf2n	132	28	.	.	.
cord-288670-1vlowf2n	133	1	In	in	IN
cord-288670-1vlowf2n	133	2	addition	addition	NN
cord-288670-1vlowf2n	133	3	,	,	,
cord-288670-1vlowf2n	133	4	teicoplanin	teicoplanin	NNP
cord-288670-1vlowf2n	133	5	,	,	,
cord-288670-1vlowf2n	133	6	a	a	DT
cord-288670-1vlowf2n	133	7	glycopeptide	glycopeptide	NN
cord-288670-1vlowf2n	133	8	antibiotic	antibiotic	NN
cord-288670-1vlowf2n	133	9	and	and	CC
cord-288670-1vlowf2n	133	10	its	-PRON-	PRP$
cord-288670-1vlowf2n	133	11	derivatives	derivative	NNS
cord-288670-1vlowf2n	133	12	inhibit	inhibit	VBP
cord-288670-1vlowf2n	133	13	the	the	DT
cord-288670-1vlowf2n	133	14	entry	entry	NN
cord-288670-1vlowf2n	133	15	of	of	IN
cord-288670-1vlowf2n	133	16	MERS	MERS	NNP
cord-288670-1vlowf2n	133	17	-	-	HYPH
cord-288670-1vlowf2n	133	18	CoV	CoV	NNP
cord-288670-1vlowf2n	133	19	and	and	CC
cord-288670-1vlowf2n	133	20	SARS	SARS	NNP
cord-288670-1vlowf2n	133	21	-	-	HYPH
cord-288670-1vlowf2n	133	22	CoV	CoV	NNP
cord-288670-1vlowf2n	133	23	by	by	IN
cord-288670-1vlowf2n	133	24	inhibition	inhibition	NN
cord-288670-1vlowf2n	133	25	of	of	IN
cord-288670-1vlowf2n	133	26	cathepsin	cathepsin	NN
cord-288670-1vlowf2n	133	27	L	l	NN
cord-288670-1vlowf2n	133	28	activity	activity	NN
cord-288670-1vlowf2n	133	29	[	[	-LRB-
cord-288670-1vlowf2n	133	30	55	55	CD
cord-288670-1vlowf2n	133	31	]	]	-RRB-
cord-288670-1vlowf2n	133	32	.	.	.
cord-288670-1vlowf2n	134	1	Interestingly	interestingly	RB
cord-288670-1vlowf2n	134	2	,	,	,
cord-288670-1vlowf2n	134	3	a	a	DT
cord-288670-1vlowf2n	134	4	serine	serine	JJ
cord-288670-1vlowf2n	134	5	protease	protease	NN
cord-288670-1vlowf2n	134	6	inhibitor	inhibitor	NN
cord-288670-1vlowf2n	134	7	camostat	camostat	NNP
cord-288670-1vlowf2n	134	8	was	be	VBD
cord-288670-1vlowf2n	134	9	known	know	VBN
cord-288670-1vlowf2n	134	10	to	to	TO
cord-288670-1vlowf2n	134	11	inhibit	inhibit	VB
cord-288670-1vlowf2n	134	12	transmembrane	transmembrane	NN
cord-288670-1vlowf2n	134	13	protease	protease	NN
cord-288670-1vlowf2n	134	14	serine	serine	NN
cord-288670-1vlowf2n	134	15	2	2	CD
cord-288670-1vlowf2n	134	16	(	(	-LRB-
cord-288670-1vlowf2n	134	17	TMPRSS2	TMPRSS2	NNP
cord-288670-1vlowf2n	134	18	)	)	-RRB-
cord-288670-1vlowf2n	134	19	and	and	CC
cord-288670-1vlowf2n	134	20	effectively	effectively	RB
cord-288670-1vlowf2n	134	21	protected	protect	VBD
cord-288670-1vlowf2n	134	22	the	the	DT
cord-288670-1vlowf2n	134	23	mice	mice	NN
cord-288670-1vlowf2n	134	24	against	against	IN
cord-288670-1vlowf2n	134	25	death	death	NN
cord-288670-1vlowf2n	134	26	caused	cause	VBN
cord-288670-1vlowf2n	134	27	by	by	IN
cord-288670-1vlowf2n	134	28	SARS	SARS	NNP
cord-288670-1vlowf2n	134	29	-	-	HYPH
cord-288670-1vlowf2n	134	30	CoV	CoV	NNP
cord-288670-1vlowf2n	134	31	infection	infection	NN
cord-288670-1vlowf2n	134	32	[	[	-LRB-
cord-288670-1vlowf2n	134	33	55	55	CD
cord-288670-1vlowf2n	134	34	]	]	-RRB-
cord-288670-1vlowf2n	134	35	.	.	.
cord-288670-1vlowf2n	135	1	More	more	RBR
cord-288670-1vlowf2n	135	2	importantly	importantly	RB
cord-288670-1vlowf2n	135	3	,	,	,
cord-288670-1vlowf2n	135	4	a	a	DT
cord-288670-1vlowf2n	135	5	very	very	RB
cord-288670-1vlowf2n	135	6	recent	recent	JJ
cord-288670-1vlowf2n	135	7	study	study	NN
cord-288670-1vlowf2n	135	8	showed	show	VBD
cord-288670-1vlowf2n	135	9	that	that	IN
cord-288670-1vlowf2n	135	10	camostat	camostat	NNP
cord-288670-1vlowf2n	135	11	can	can	MD
cord-288670-1vlowf2n	135	12	also	also	RB
cord-288670-1vlowf2n	135	13	block	block	VB
cord-288670-1vlowf2n	135	14	the	the	DT
cord-288670-1vlowf2n	135	15	entry	entry	NN
cord-288670-1vlowf2n	135	16	of	of	IN
cord-288670-1vlowf2n	135	17	SARS	SARS	NNP
cord-288670-1vlowf2n	135	18	-	-	HYPH
cord-288670-1vlowf2n	135	19	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	135	20	by	by	IN
cord-288670-1vlowf2n	135	21	inhibiting	inhibit	VBG
cord-288670-1vlowf2n	135	22	ACE2	ACE2	NNP
cord-288670-1vlowf2n	135	23	and	and	CC
cord-288670-1vlowf2n	135	24	TMPRSS2	TMPRSS2	NNP
cord-288670-1vlowf2n	135	25	[	[	-LRB-
cord-288670-1vlowf2n	135	26	67	67	CD
cord-288670-1vlowf2n	135	27	]	]	-RRB-
cord-288670-1vlowf2n	135	28	.	.	.
cord-288670-1vlowf2n	136	1	Since	since	IN
cord-288670-1vlowf2n	136	2	camostat	camostat	NNP
cord-288670-1vlowf2n	136	3	is	be	VBZ
cord-288670-1vlowf2n	136	4	already	already	RB
cord-288670-1vlowf2n	136	5	in	in	IN
cord-288670-1vlowf2n	136	6	clinical	clinical	JJ
cord-288670-1vlowf2n	136	7	use	use	NN
cord-288670-1vlowf2n	136	8	for	for	IN
cord-288670-1vlowf2n	136	9	the	the	DT
cord-288670-1vlowf2n	136	10	treatment	treatment	NN
cord-288670-1vlowf2n	136	11	of	of	IN
cord-288670-1vlowf2n	136	12	chronic	chronic	JJ
cord-288670-1vlowf2n	136	13	pancreatitis	pancreatitis	NN
cord-288670-1vlowf2n	136	14	,	,	,
cord-288670-1vlowf2n	136	15	suggesting	suggest	VBG
cord-288670-1vlowf2n	136	16	its	-PRON-	PRP$
cord-288670-1vlowf2n	136	17	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	136	18	potential	potential	NN
cord-288670-1vlowf2n	136	19	for	for	IN
cord-288670-1vlowf2n	136	20	treatment	treatment	NN
cord-288670-1vlowf2n	136	21	of	of	IN
cord-288670-1vlowf2n	136	22	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	136	23	.	.	.
cord-288670-1vlowf2n	137	1	As	as	IN
cord-288670-1vlowf2n	137	2	discussed	discuss	VBN
cord-288670-1vlowf2n	137	3	earlier	early	RBR
cord-288670-1vlowf2n	137	4	,	,	,
cord-288670-1vlowf2n	137	5	clathrin	clathrin	NN
cord-288670-1vlowf2n	137	6	-	-	HYPH
cord-288670-1vlowf2n	137	7	mediated	mediate	VBN
cord-288670-1vlowf2n	137	8	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	137	9	is	be	VBZ
cord-288670-1vlowf2n	137	10	one	one	CD
cord-288670-1vlowf2n	137	11	of	of	IN
cord-288670-1vlowf2n	137	12	the	the	DT
cord-288670-1vlowf2n	137	13	key	key	JJ
cord-288670-1vlowf2n	137	14	mechanisms	mechanism	NNS
cord-288670-1vlowf2n	137	15	for	for	IN
cord-288670-1vlowf2n	137	16	viral	viral	JJ
cord-288670-1vlowf2n	137	17	entry	entry	NN
cord-288670-1vlowf2n	137	18	into	into	IN
cord-288670-1vlowf2n	137	19	the	the	DT
cord-288670-1vlowf2n	137	20	host	host	NN
cord-288670-1vlowf2n	137	21	cells	cell	NNS
cord-288670-1vlowf2n	137	22	,	,	,
cord-288670-1vlowf2n	137	23	including	include	VBG
cord-288670-1vlowf2n	137	24	MHV	MHV	NNP
cord-288670-1vlowf2n	137	25	[	[	-LRB-
cord-288670-1vlowf2n	137	26	50	50	CD
cord-288670-1vlowf2n	137	27	,	,	,
cord-288670-1vlowf2n	137	28	52	52	CD
cord-288670-1vlowf2n	137	29	,	,	,
cord-288670-1vlowf2n	137	30	54	54	CD
cord-288670-1vlowf2n	137	31	]	]	-RRB-
cord-288670-1vlowf2n	137	32	,	,	,
cord-288670-1vlowf2n	137	33	SARS	SARS	NNP
cord-288670-1vlowf2n	137	34	-	-	HYPH
cord-288670-1vlowf2n	137	35	CoV	CoV	NNP
cord-288670-1vlowf2n	137	36	[	[	-LRB-
cord-288670-1vlowf2n	137	37	38	38	CD
cord-288670-1vlowf2n	137	38	]	]	-RRB-
cord-288670-1vlowf2n	137	39	,	,	,
cord-288670-1vlowf2n	137	40	and	and	CC
cord-288670-1vlowf2n	137	41	MERS	MERS	NNP
cord-288670-1vlowf2n	137	42	-	-	HYPH
cord-288670-1vlowf2n	137	43	CoV	CoV	NNP
cord-288670-1vlowf2n	137	44	[	[	-LRB-
cord-288670-1vlowf2n	137	45	53	53	CD
cord-288670-1vlowf2n	137	46	,	,	,
cord-288670-1vlowf2n	137	47	54	54	CD
cord-288670-1vlowf2n	137	48	]	]	-RRB-
cord-288670-1vlowf2n	137	49	.	.	.
cord-288670-1vlowf2n	138	1	Therefore	therefore	RB
cord-288670-1vlowf2n	138	2	,	,	,
cord-288670-1vlowf2n	138	3	chlorpromazine	chlorpromazine	NN
cord-288670-1vlowf2n	138	4	,	,	,
cord-288670-1vlowf2n	138	5	an	an	DT
cord-288670-1vlowf2n	138	6	inhibitor	inhibitor	NN
cord-288670-1vlowf2n	138	7	for	for	IN
cord-288670-1vlowf2n	138	8	clathrin	clathrin	NN
cord-288670-1vlowf2n	138	9	-	-	HYPH
cord-288670-1vlowf2n	138	10	dependent	dependent	JJ
cord-288670-1vlowf2n	138	11	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	138	12	,	,	,
cord-288670-1vlowf2n	138	13	have	have	VBP
cord-288670-1vlowf2n	138	14	been	be	VBN
cord-288670-1vlowf2n	138	15	consistently	consistently	RB
cord-288670-1vlowf2n	138	16	found	find	VBN
cord-288670-1vlowf2n	138	17	to	to	TO
cord-288670-1vlowf2n	138	18	possess	possess	VB
cord-288670-1vlowf2n	138	19	significant	significant	JJ
cord-288670-1vlowf2n	138	20	inhibitory	inhibitory	JJ
cord-288670-1vlowf2n	138	21	effect	effect	NN
cord-288670-1vlowf2n	138	22	on	on	IN
cord-288670-1vlowf2n	138	23	the	the	DT
cord-288670-1vlowf2n	138	24	entry	entry	NN
cord-288670-1vlowf2n	138	25	of	of	IN
cord-288670-1vlowf2n	138	26	those	those	DT
cord-288670-1vlowf2n	138	27	CoVs	CoVs	NNP
cord-288670-1vlowf2n	138	28	[	[	-LRB-
cord-288670-1vlowf2n	138	29	39	39	CD
cord-288670-1vlowf2n	138	30	]	]	-RRB-
cord-288670-1vlowf2n	138	31	.	.	.
cord-288670-1vlowf2n	139	1	In	in	IN
cord-288670-1vlowf2n	139	2	fact	fact	NN
cord-288670-1vlowf2n	139	3	,	,	,
cord-288670-1vlowf2n	139	4	chlorpromazine	chlorpromazine	NN
cord-288670-1vlowf2n	139	5	is	be	VBZ
cord-288670-1vlowf2n	139	6	a	a	DT
cord-288670-1vlowf2n	139	7	FDA	FDA	NNP
cord-288670-1vlowf2n	139	8	-	-	HYPH
cord-288670-1vlowf2n	139	9	approved	approve	VBN
cord-288670-1vlowf2n	139	10	drug	drug	NN
cord-288670-1vlowf2n	139	11	widely	widely	RB
cord-288670-1vlowf2n	139	12	used	use	VBN
cord-288670-1vlowf2n	139	13	for	for	IN
cord-288670-1vlowf2n	139	14	treatment	treatment	NN
cord-288670-1vlowf2n	139	15	of	of	IN
cord-288670-1vlowf2n	139	16	psychotic	psychotic	JJ
cord-288670-1vlowf2n	139	17	disorders	disorder	NNS
cord-288670-1vlowf2n	139	18	such	such	JJ
cord-288670-1vlowf2n	139	19	as	as	IN
cord-288670-1vlowf2n	139	20	schizophrenia	schizophrenia	NNP
cord-288670-1vlowf2n	139	21	[	[	-LRB-
cord-288670-1vlowf2n	139	22	68	68	CD
cord-288670-1vlowf2n	139	23	]	]	-RRB-
cord-288670-1vlowf2n	139	24	.	.	.
cord-288670-1vlowf2n	140	1	Importantly	importantly	RB
cord-288670-1vlowf2n	140	2	,	,	,
cord-288670-1vlowf2n	140	3	it	-PRON-	PRP
cord-288670-1vlowf2n	140	4	has	have	VBZ
cord-288670-1vlowf2n	140	5	been	be	VBN
cord-288670-1vlowf2n	140	6	well	well	RB
cord-288670-1vlowf2n	140	7	established	establish	VBN
cord-288670-1vlowf2n	140	8	for	for	IN
cord-288670-1vlowf2n	140	9	its	-PRON-	PRP$
cord-288670-1vlowf2n	140	10	antivirus	antivirus	JJ
cord-288670-1vlowf2n	140	11	function	function	NN
cord-288670-1vlowf2n	140	12	for	for	IN
cord-288670-1vlowf2n	140	13	many	many	JJ
cord-288670-1vlowf2n	140	14	types	type	NNS
cord-288670-1vlowf2n	140	15	of	of	IN
cord-288670-1vlowf2n	140	16	viruses	virus	NNS
cord-288670-1vlowf2n	140	17	,	,	,
cord-288670-1vlowf2n	140	18	including	include	VBG
cord-288670-1vlowf2n	140	19	SARS	SARS	NNP
cord-288670-1vlowf2n	140	20	-	-	HYPH
cord-288670-1vlowf2n	140	21	CoV	CoV	NNP
cord-288670-1vlowf2n	140	22	and	and	CC
cord-288670-1vlowf2n	140	23	MERS	MERS	NNP
cord-288670-1vlowf2n	140	24	-	-	HYPH
cord-288670-1vlowf2n	140	25	CoVs	CoVs	NNP
cord-288670-1vlowf2n	140	26	,	,	,
cord-288670-1vlowf2n	140	27	as	as	IN
cord-288670-1vlowf2n	140	28	summarized	summarize	VBN
cord-288670-1vlowf2n	140	29	in	in	IN
cord-288670-1vlowf2n	140	30	Table	Table	NNP
cord-288670-1vlowf2n	140	31	2	2	CD
cord-288670-1vlowf2n	140	32	.	.	.
cord-288670-1vlowf2n	141	1	At	at	IN
cord-288670-1vlowf2n	141	2	present	present	NN
cord-288670-1vlowf2n	141	3	,	,	,
cord-288670-1vlowf2n	141	4	the	the	DT
cord-288670-1vlowf2n	141	5	clinical	clinical	JJ
cord-288670-1vlowf2n	141	6	application	application	NN
cord-288670-1vlowf2n	141	7	of	of	IN
cord-288670-1vlowf2n	141	8	chlorpromazine	chlorpromazine	NN
cord-288670-1vlowf2n	141	9	in	in	IN
cord-288670-1vlowf2n	141	10	treatment	treatment	NN
cord-288670-1vlowf2n	141	11	of	of	IN
cord-288670-1vlowf2n	141	12	SARS	SARS	NNP
cord-288670-1vlowf2n	141	13	and	and	CC
cord-288670-1vlowf2n	141	14	MERS	MERS	NNP
cord-288670-1vlowf2n	141	15	has	have	VBZ
cord-288670-1vlowf2n	141	16	not	not	RB
cord-288670-1vlowf2n	141	17	been	be	VBN
cord-288670-1vlowf2n	141	18	reported	report	VBN
cord-288670-1vlowf2n	141	19	and	and	CC
cord-288670-1vlowf2n	141	20	it	-PRON-	PRP
cord-288670-1vlowf2n	141	21	would	would	MD
cord-288670-1vlowf2n	141	22	be	be	VB
cord-288670-1vlowf2n	141	23	of	of	IN
cord-288670-1vlowf2n	141	24	interest	interest	NN
cord-288670-1vlowf2n	141	25	to	to	TO
cord-288670-1vlowf2n	141	26	conduct	conduct	VB
cord-288670-1vlowf2n	141	27	clinical	clinical	JJ
cord-288670-1vlowf2n	141	28	trials	trial	NNS
cord-288670-1vlowf2n	141	29	for	for	IN
cord-288670-1vlowf2n	141	30	testing	test	VBG
cord-288670-1vlowf2n	141	31	the	the	DT
cord-288670-1vlowf2n	141	32	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	141	33	effect	effect	NN
cord-288670-1vlowf2n	141	34	of	of	IN
cord-288670-1vlowf2n	141	35	chlorpromazine	chlorpromazine	NN
cord-288670-1vlowf2n	141	36	on	on	IN
cord-288670-1vlowf2n	141	37	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	141	38	.	.	.
cord-288670-1vlowf2n	142	1	In	in	IN
cord-288670-1vlowf2n	142	2	addition	addition	NN
cord-288670-1vlowf2n	142	3	,	,	,
cord-288670-1vlowf2n	142	4	two	two	CD
cord-288670-1vlowf2n	142	5	cardiotonic	cardiotonic	NNP
cord-288670-1vlowf2n	142	6	steroids	steroid	NNS
cord-288670-1vlowf2n	142	7	ouabain	ouabain	VBP
cord-288670-1vlowf2n	142	8	and	and	CC
cord-288670-1vlowf2n	142	9	bufalin	bufalin	NNP
cord-288670-1vlowf2n	142	10	,	,	,
cord-288670-1vlowf2n	142	11	selective	selective	JJ
cord-288670-1vlowf2n	142	12	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	142	13	of	of	IN
cord-288670-1vlowf2n	142	14	the	the	DT
cord-288670-1vlowf2n	142	15	plasma	plasma	NN
cord-288670-1vlowf2n	142	16	membrane	membrane	NN
cord-288670-1vlowf2n	143	1	Na	Na	NNP
cord-288670-1vlowf2n	143	2	+	+	CC
cord-288670-1vlowf2n	143	3	/K	/K	.
cord-288670-1vlowf2n	144	1	+	+	CC
cord-288670-1vlowf2n	144	2	-ATPase	-atpase	NN
cord-288670-1vlowf2n	144	3	,	,	,
cord-288670-1vlowf2n	144	4	have	have	VBP
cord-288670-1vlowf2n	144	5	been	be	VBN
cord-288670-1vlowf2n	144	6	shown	show	VBN
cord-288670-1vlowf2n	144	7	to	to	TO
cord-288670-1vlowf2n	144	8	inhibit	inhibit	VB
cord-288670-1vlowf2n	144	9	the	the	DT
cord-288670-1vlowf2n	144	10	MERS	MERS	NNP
cord-288670-1vlowf2n	144	11	-	-	HYPH
cord-288670-1vlowf2n	144	12	CoV	cov	NN
cord-288670-1vlowf2n	144	13	infection	infection	NN
cord-288670-1vlowf2n	144	14	at	at	IN
cord-288670-1vlowf2n	144	15	nanomolar	nanomolar	NNP
cord-288670-1vlowf2n	144	16	concentrations	concentration	NNS
cord-288670-1vlowf2n	144	17	via	via	IN
cord-288670-1vlowf2n	144	18	affecting	affect	VBG
cord-288670-1vlowf2n	144	19	the	the	DT
cord-288670-1vlowf2n	144	20	clathrin	clathrin	NN
cord-288670-1vlowf2n	144	21	-	-	HYPH
cord-288670-1vlowf2n	144	22	mediated	mediate	VBN
cord-288670-1vlowf2n	144	23	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	144	24	pathway	pathway	NN
cord-288670-1vlowf2n	144	25	[	[	-LRB-
cord-288670-1vlowf2n	144	26	54	54	CD
cord-288670-1vlowf2n	144	27	]	]	-RRB-
cord-288670-1vlowf2n	144	28	.	.	.
cord-288670-1vlowf2n	145	1	Since	since	IN
cord-288670-1vlowf2n	145	2	both	both	DT
cord-288670-1vlowf2n	145	3	of	of	IN
cord-288670-1vlowf2n	145	4	them	-PRON-	PRP
cord-288670-1vlowf2n	145	5	are	be	VBP
cord-288670-1vlowf2n	145	6	also	also	RB
cord-288670-1vlowf2n	145	7	FDA	FDA	NNP
cord-288670-1vlowf2n	145	8	-	-	HYPH
cord-288670-1vlowf2n	145	9	approved	approve	VBN
cord-288670-1vlowf2n	145	10	drugs	drug	NNS
cord-288670-1vlowf2n	145	11	and	and	CC
cord-288670-1vlowf2n	145	12	clinically	clinically	RB
cord-288670-1vlowf2n	145	13	available	available	JJ
cord-288670-1vlowf2n	145	14	,	,	,
cord-288670-1vlowf2n	145	15	it	-PRON-	PRP
cord-288670-1vlowf2n	145	16	would	would	MD
cord-288670-1vlowf2n	145	17	be	be	VB
cord-288670-1vlowf2n	145	18	of	of	IN
cord-288670-1vlowf2n	145	19	interest	interest	NN
cord-288670-1vlowf2n	145	20	to	to	TO
cord-288670-1vlowf2n	145	21	test	test	VB
cord-288670-1vlowf2n	145	22	them	-PRON-	PRP
cord-288670-1vlowf2n	145	23	clinically	clinically	RB
cord-288670-1vlowf2n	145	24	for	for	IN
cord-288670-1vlowf2n	145	25	treatment	treatment	NN
cord-288670-1vlowf2n	145	26	of	of	IN
cord-288670-1vlowf2n	145	27	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	145	28	.	.	.
cord-288670-1vlowf2n	146	1	The	the	DT
cord-288670-1vlowf2n	146	2	current	current	JJ
cord-288670-1vlowf2n	146	3	ongoing	ongoing	JJ
cord-288670-1vlowf2n	146	4	epidemic	epidemic	NN
cord-288670-1vlowf2n	146	5	of	of	IN
cord-288670-1vlowf2n	146	6	SARS	SARS	NNP
cord-288670-1vlowf2n	146	7	-	-	HYPH
cord-288670-1vlowf2n	146	8	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	146	9	and	and	CC
cord-288670-1vlowf2n	146	10	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	146	11	worldwide	worldwide	RB
cord-288670-1vlowf2n	146	12	has	have	VBZ
cord-288670-1vlowf2n	146	13	emerged	emerge	VBN
cord-288670-1vlowf2n	146	14	as	as	IN
cord-288670-1vlowf2n	146	15	a	a	DT
cord-288670-1vlowf2n	146	16	significant	significant	JJ
cord-288670-1vlowf2n	146	17	global	global	JJ
cord-288670-1vlowf2n	146	18	public	public	JJ
cord-288670-1vlowf2n	146	19	health	health	NN
cord-288670-1vlowf2n	146	20	threat	threat	NN
cord-288670-1vlowf2n	146	21	.	.	.
cord-288670-1vlowf2n	147	1	While	while	IN
cord-288670-1vlowf2n	147	2	urgent	urgent	JJ
cord-288670-1vlowf2n	147	3	regulatory	regulatory	JJ
cord-288670-1vlowf2n	147	4	measures	measure	NNS
cord-288670-1vlowf2n	147	5	in	in	IN
cord-288670-1vlowf2n	147	6	control	control	NN
cord-288670-1vlowf2n	147	7	of	of	IN
cord-288670-1vlowf2n	147	8	the	the	DT
cord-288670-1vlowf2n	147	9	rapid	rapid	JJ
cord-288670-1vlowf2n	147	10	spread	spread	NN
cord-288670-1vlowf2n	147	11	of	of	IN
cord-288670-1vlowf2n	147	12	this	this	DT
cord-288670-1vlowf2n	147	13	virus	virus	NN
cord-288670-1vlowf2n	147	14	are	be	VBP
cord-288670-1vlowf2n	147	15	essential	essential	JJ
cord-288670-1vlowf2n	147	16	,	,	,
cord-288670-1vlowf2n	147	17	scientists	scientist	NNS
cord-288670-1vlowf2n	147	18	around	around	IN
cord-288670-1vlowf2n	147	19	the	the	DT
cord-288670-1vlowf2n	147	20	world	world	NN
cord-288670-1vlowf2n	147	21	have	have	VBP
cord-288670-1vlowf2n	147	22	quickly	quickly	RB
cord-288670-1vlowf2n	147	23	engaged	engage	VBN
cord-288670-1vlowf2n	147	24	in	in	IN
cord-288670-1vlowf2n	147	25	this	this	DT
cord-288670-1vlowf2n	147	26	battle	battle	NN
cord-288670-1vlowf2n	147	27	by	by	IN
cord-288670-1vlowf2n	147	28	studying	study	VBG
cord-288670-1vlowf2n	147	29	the	the	DT
cord-288670-1vlowf2n	147	30	molecular	molecular	JJ
cord-288670-1vlowf2n	147	31	mechanisms	mechanism	NNS
cord-288670-1vlowf2n	147	32	and	and	CC
cord-288670-1vlowf2n	147	33	searching	search	VBG
cord-288670-1vlowf2n	147	34	for	for	IN
cord-288670-1vlowf2n	147	35	effective	effective	JJ
cord-288670-1vlowf2n	147	36	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	147	37	strategies	strategy	NNS
cord-288670-1vlowf2n	147	38	against	against	IN
cord-288670-1vlowf2n	147	39	this	this	DT
cord-288670-1vlowf2n	147	40	deadly	deadly	JJ
cord-288670-1vlowf2n	147	41	disease	disease	NN
cord-288670-1vlowf2n	147	42	.	.	.
cord-288670-1vlowf2n	148	1	At	at	IN
cord-288670-1vlowf2n	148	2	present	present	NN
cord-288670-1vlowf2n	148	3	,	,	,
cord-288670-1vlowf2n	148	4	while	while	IN
cord-288670-1vlowf2n	148	5	the	the	DT
cord-288670-1vlowf2n	148	6	exact	exact	JJ
cord-288670-1vlowf2n	148	7	role	role	NN
cord-288670-1vlowf2n	148	8	of	of	IN
cord-288670-1vlowf2n	148	9	autophagy	autophagy	NN
cord-288670-1vlowf2n	148	10	remains	remain	VBZ
cord-288670-1vlowf2n	148	11	debatable	debatable	JJ
cord-288670-1vlowf2n	148	12	,	,	,
cord-288670-1vlowf2n	148	13	there	there	EX
cord-288670-1vlowf2n	148	14	is	be	VBZ
cord-288670-1vlowf2n	148	15	overwhelming	overwhelming	JJ
cord-288670-1vlowf2n	148	16	evidence	evidence	NN
cord-288670-1vlowf2n	148	17	suggesting	suggest	VBG
cord-288670-1vlowf2n	148	18	that	that	IN
cord-288670-1vlowf2n	148	19	the	the	DT
cord-288670-1vlowf2n	148	20	endocytic	endocytic	JJ
cord-288670-1vlowf2n	148	21	pathway	pathway	NN
cord-288670-1vlowf2n	148	22	plays	play	VBZ
cord-288670-1vlowf2n	148	23	a	a	DT
cord-288670-1vlowf2n	148	24	key	key	JJ
cord-288670-1vlowf2n	148	25	role	role	NN
cord-288670-1vlowf2n	148	26	in	in	IN
cord-288670-1vlowf2n	148	27	mediating	mediate	VBG
cord-288670-1vlowf2n	148	28	viral	viral	JJ
cord-288670-1vlowf2n	148	29	entry	entry	NN
cord-288670-1vlowf2n	148	30	for	for	IN
cord-288670-1vlowf2n	148	31	many	many	JJ
cord-288670-1vlowf2n	148	32	CoVs	CoVs	NNP
cord-288670-1vlowf2n	148	33	including	include	VBG
cord-288670-1vlowf2n	148	34	SARS	SARS	NNP
cord-288670-1vlowf2n	148	35	-	-	HYPH
cord-288670-1vlowf2n	148	36	CoVs	CoVs	NNP
cord-288670-1vlowf2n	148	37	,	,	,
cord-288670-1vlowf2n	148	38	MERS	MERS	NNP
cord-288670-1vlowf2n	148	39	-	-	HYPH
cord-288670-1vlowf2n	148	40	CoVs	CoVs	NNP
cord-288670-1vlowf2n	148	41	and	and	CC
cord-288670-1vlowf2n	148	42	possibly	possibly	RB
cord-288670-1vlowf2n	148	43	SARS	SARS	NNP
cord-288670-1vlowf2n	148	44	-	-	HYPH
cord-288670-1vlowf2n	148	45	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	148	46	.	.	.
cord-288670-1vlowf2n	149	1	As	as	IN
cord-288670-1vlowf2n	149	2	a	a	DT
cord-288670-1vlowf2n	149	3	result	result	NN
cord-288670-1vlowf2n	149	4	,	,	,
cord-288670-1vlowf2n	149	5	several	several	JJ
cord-288670-1vlowf2n	149	6	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	149	7	targeting	target	VBG
cord-288670-1vlowf2n	149	8	the	the	DT
cord-288670-1vlowf2n	149	9	endocytic	endocytic	JJ
cord-288670-1vlowf2n	149	10	pathway	pathway	NN
cord-288670-1vlowf2n	149	11	appear	appear	VBP
cord-288670-1vlowf2n	149	12	to	to	TO
cord-288670-1vlowf2n	149	13	have	have	VB
cord-288670-1vlowf2n	149	14	the	the	DT
cord-288670-1vlowf2n	149	15	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	149	16	potential	potential	NN
cord-288670-1vlowf2n	149	17	in	in	IN
cord-288670-1vlowf2n	149	18	treatment	treatment	NN
cord-288670-1vlowf2n	149	19	of	of	IN
cord-288670-1vlowf2n	149	20	COVID-19	COVID-19	NNP
cord-288670-1vlowf2n	149	21	,	,	,
cord-288670-1vlowf2n	149	22	including	include	VBG
cord-288670-1vlowf2n	149	23	a	a	DT
cord-288670-1vlowf2n	149	24	lysosomotropic	lysosomotropic	JJ
cord-288670-1vlowf2n	149	25	agent	agent	NN
cord-288670-1vlowf2n	149	26	CQ	CQ	NNP
cord-288670-1vlowf2n	149	27	and	and	CC
cord-288670-1vlowf2n	149	28	a	a	DT
cord-288670-1vlowf2n	149	29	clathrin	clathrin	NN
cord-288670-1vlowf2n	149	30	-	-	HYPH
cord-288670-1vlowf2n	149	31	mediated	mediate	VBN
cord-288670-1vlowf2n	149	32	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	149	33	inhibitor	inhibitor	NN
cord-288670-1vlowf2n	149	34	chlorpromazine	chlorpromazine	NN
cord-288670-1vlowf2n	149	35	[	[	-LRB-
cord-288670-1vlowf2n	149	36	43	43	CD
cord-288670-1vlowf2n	149	37	,	,	,
cord-288670-1vlowf2n	149	38	63	63	CD
cord-288670-1vlowf2n	149	39	,	,	,
cord-288670-1vlowf2n	149	40	65	65	CD
cord-288670-1vlowf2n	149	41	,	,	,
cord-288670-1vlowf2n	149	42	68	68	CD
cord-288670-1vlowf2n	149	43	]	]	-RRB-
cord-288670-1vlowf2n	149	44	.	.	.
cord-288670-1vlowf2n	150	1	Since	since	IN
cord-288670-1vlowf2n	150	2	both	both	DT
cord-288670-1vlowf2n	150	3	are	be	VBP
cord-288670-1vlowf2n	150	4	FDA	FDA	NNP
cord-288670-1vlowf2n	150	5	-	-	HYPH
cord-288670-1vlowf2n	150	6	approved	approve	VBN
cord-288670-1vlowf2n	150	7	and	and	CC
cord-288670-1vlowf2n	150	8	clinically	clinically	RB
cord-288670-1vlowf2n	150	9	available	available	JJ
cord-288670-1vlowf2n	150	10	,	,	,
cord-288670-1vlowf2n	150	11	clinical	clinical	JJ
cord-288670-1vlowf2n	150	12	trials	trial	NNS
cord-288670-1vlowf2n	150	13	either	either	CC
cord-288670-1vlowf2n	150	14	as	as	IN
cord-288670-1vlowf2n	150	15	a	a	DT
cord-288670-1vlowf2n	150	16	single	single	JJ
cord-288670-1vlowf2n	150	17	therapy	therapy	NN
cord-288670-1vlowf2n	150	18	or	or	CC
cord-288670-1vlowf2n	150	19	in	in	IN
cord-288670-1vlowf2n	150	20	combination	combination	NN
cord-288670-1vlowf2n	150	21	with	with	IN
cord-288670-1vlowf2n	150	22	other	other	JJ
cord-288670-1vlowf2n	150	23	anti	anti	JJ
cord-288670-1vlowf2n	150	24	-	-	JJ
cord-288670-1vlowf2n	150	25	viral	viral	JJ
cord-288670-1vlowf2n	150	26	drugs	drug	NNS
cord-288670-1vlowf2n	150	27	are	be	VBP
cord-288670-1vlowf2n	150	28	much	much	RB
cord-288670-1vlowf2n	150	29	needed	need	VBN
cord-288670-1vlowf2n	150	30	.	.	.
cord-288670-1vlowf2n	151	1	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	151	2	pathogenesis	pathogenesis	NN
cord-288670-1vlowf2n	151	3	and	and	CC
cord-288670-1vlowf2n	151	4	the	the	DT
cord-288670-1vlowf2n	151	5	emerging	emerge	VBG
cord-288670-1vlowf2n	151	6	pathogen	pathogen	NN
cord-288670-1vlowf2n	151	7	severe	severe	JJ
cord-288670-1vlowf2n	151	8	acute	acute	JJ
cord-288670-1vlowf2n	151	9	respiratory	respiratory	JJ
cord-288670-1vlowf2n	151	10	syndrome	syndrome	NN
cord-288670-1vlowf2n	151	11	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	151	12	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	151	13	envelope	envelope	NN
cord-288670-1vlowf2n	151	14	protein	protein	NN
cord-288670-1vlowf2n	151	15	:	:	:
cord-288670-1vlowf2n	151	16	current	current	JJ
cord-288670-1vlowf2n	151	17	knowledge	knowledge	NN
cord-288670-1vlowf2n	152	1	Lysosomal	Lysosomal	NNP
cord-288670-1vlowf2n	152	2	Proteases	Proteases	NNP
cord-288670-1vlowf2n	152	3	Are	be	VBP
cord-288670-1vlowf2n	152	4	a	a	DT
cord-288670-1vlowf2n	152	5	Determinant	determinant	NN
cord-288670-1vlowf2n	152	6	of	of	IN
cord-288670-1vlowf2n	152	7	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	152	8	Tropism	Tropism	NNP
cord-288670-1vlowf2n	152	9	A	a	DT
cord-288670-1vlowf2n	152	10	Novel	Novel	NNP
cord-288670-1vlowf2n	152	11	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	152	12	from	from	IN
cord-288670-1vlowf2n	152	13	Patients	patient	NNS
cord-288670-1vlowf2n	152	14	with	with	IN
cord-288670-1vlowf2n	152	15	Pneumonia	Pneumonia	NNP
cord-288670-1vlowf2n	152	16	in	in	IN
cord-288670-1vlowf2n	152	17	China	China	NNP
cord-288670-1vlowf2n	153	1	A	a	DT
cord-288670-1vlowf2n	153	2	pneumonia	pneumonia	NN
cord-288670-1vlowf2n	153	3	outbreak	outbreak	NN
cord-288670-1vlowf2n	153	4	associated	associate	VBN
cord-288670-1vlowf2n	153	5	with	with	IN
cord-288670-1vlowf2n	153	6	a	a	DT
cord-288670-1vlowf2n	153	7	new	new	JJ
cord-288670-1vlowf2n	153	8	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	153	9	of	of	IN
cord-288670-1vlowf2n	153	10	probable	probable	JJ
cord-288670-1vlowf2n	153	11	bat	bat	NN
cord-288670-1vlowf2n	153	12	origin	origin	NN
cord-288670-1vlowf2n	153	13	A	a	DT
cord-288670-1vlowf2n	153	14	brief	brief	JJ
cord-288670-1vlowf2n	153	15	history	history	NN
cord-288670-1vlowf2n	153	16	of	of	IN
cord-288670-1vlowf2n	153	17	autophagy	autophagy	NN
cord-288670-1vlowf2n	153	18	from	from	IN
cord-288670-1vlowf2n	153	19	cell	cell	NN
cord-288670-1vlowf2n	153	20	biology	biology	NN
cord-288670-1vlowf2n	153	21	to	to	IN
cord-288670-1vlowf2n	153	22	physiology	physiology	NN
cord-288670-1vlowf2n	153	23	and	and	CC
cord-288670-1vlowf2n	153	24	disease	disease	NN
cord-288670-1vlowf2n	153	25	Biological	Biological	NNP
cord-288670-1vlowf2n	153	26	Functions	Functions	NNPS
cord-288670-1vlowf2n	153	27	of	of	IN
cord-288670-1vlowf2n	153	28	Autophagy	Autophagy	NNP
cord-288670-1vlowf2n	153	29	Genes	Genes	NNPS
cord-288670-1vlowf2n	153	30	:	:	:
cord-288670-1vlowf2n	154	1	A	a	DT
cord-288670-1vlowf2n	154	2	Disease	Disease	NNP
cord-288670-1vlowf2n	154	3	Perspective	Perspective	NNP
cord-288670-1vlowf2n	154	4	Autophagy	Autophagy	NNP
cord-288670-1vlowf2n	154	5	:	:	:
cord-288670-1vlowf2n	154	6	machinery	machinery	NN
cord-288670-1vlowf2n	154	7	and	and	CC
cord-288670-1vlowf2n	154	8	regulation	regulation	NN
cord-288670-1vlowf2n	155	1	The	the	DT
cord-288670-1vlowf2n	155	2	ATG	ATG	NNP
cord-288670-1vlowf2n	155	3	conjugation	conjugation	NN
cord-288670-1vlowf2n	155	4	systems	system	NNS
cord-288670-1vlowf2n	155	5	in	in	IN
cord-288670-1vlowf2n	155	6	autophagy	autophagy	NN
cord-288670-1vlowf2n	155	7	Autophagy	Autophagy	NNP
cord-288670-1vlowf2n	155	8	in	in	IN
cord-288670-1vlowf2n	155	9	mammalian	mammalian	JJ
cord-288670-1vlowf2n	155	10	development	development	NN
cord-288670-1vlowf2n	155	11	and	and	CC
cord-288670-1vlowf2n	155	12	differentiation	differentiation	NN
cord-288670-1vlowf2n	155	13	Autophagy	Autophagy	NNP
cord-288670-1vlowf2n	155	14	in	in	IN
cord-288670-1vlowf2n	155	15	human	human	JJ
cord-288670-1vlowf2n	155	16	health	health	NN
cord-288670-1vlowf2n	155	17	and	and	CC
cord-288670-1vlowf2n	155	18	disease	disease	NN
cord-288670-1vlowf2n	155	19	Autophagy	Autophagy	NNP
cord-288670-1vlowf2n	155	20	:	:	:
cord-288670-1vlowf2n	155	21	regulation	regulation	NN
cord-288670-1vlowf2n	155	22	and	and	CC
cord-288670-1vlowf2n	155	23	role	role	NN
cord-288670-1vlowf2n	155	24	in	in	IN
cord-288670-1vlowf2n	155	25	disease	disease	NN
cord-288670-1vlowf2n	155	26	Autophagy	Autophagy	NNP
cord-288670-1vlowf2n	155	27	and	and	CC
cord-288670-1vlowf2n	155	28	human	human	JJ
cord-288670-1vlowf2n	155	29	diseases	disease	NNS
cord-288670-1vlowf2n	156	1	Autophagy	autophagy	UH
cord-288670-1vlowf2n	156	2	:	:	:
cord-288670-1vlowf2n	156	3	a	a	DT
cord-288670-1vlowf2n	156	4	lysosomal	lysosomal	JJ
cord-288670-1vlowf2n	156	5	degradation	degradation	NN
cord-288670-1vlowf2n	156	6	pathway	pathway	NN
cord-288670-1vlowf2n	156	7	with	with	IN
cord-288670-1vlowf2n	156	8	a	a	DT
cord-288670-1vlowf2n	156	9	central	central	JJ
cord-288670-1vlowf2n	156	10	role	role	NN
cord-288670-1vlowf2n	156	11	in	in	IN
cord-288670-1vlowf2n	156	12	health	health	NN
cord-288670-1vlowf2n	156	13	and	and	CC
cord-288670-1vlowf2n	156	14	disease	disease	NN
cord-288670-1vlowf2n	156	15	At	at	IN
cord-288670-1vlowf2n	156	16	the	the	DT
cord-288670-1vlowf2n	156	17	end	end	NN
cord-288670-1vlowf2n	156	18	of	of	IN
cord-288670-1vlowf2n	156	19	the	the	DT
cord-288670-1vlowf2n	156	20	autophagic	autophagic	NNP
cord-288670-1vlowf2n	156	21	road	road	NN
cord-288670-1vlowf2n	156	22	:	:	:
cord-288670-1vlowf2n	156	23	an	an	DT
cord-288670-1vlowf2n	156	24	emerging	emerge	VBG
cord-288670-1vlowf2n	156	25	understanding	understanding	NN
cord-288670-1vlowf2n	156	26	of	of	IN
cord-288670-1vlowf2n	156	27	lysosomal	lysosomal	JJ
cord-288670-1vlowf2n	156	28	functions	function	NNS
cord-288670-1vlowf2n	156	29	in	in	IN
cord-288670-1vlowf2n	156	30	autophagy	autophagy	NN
cord-288670-1vlowf2n	156	31	Signals	signal	NNS
cord-288670-1vlowf2n	156	32	from	from	IN
cord-288670-1vlowf2n	156	33	the	the	DT
cord-288670-1vlowf2n	156	34	lysosome	lysosome	NN
cord-288670-1vlowf2n	156	35	:	:	:
cord-288670-1vlowf2n	156	36	a	a	DT
cord-288670-1vlowf2n	156	37	control	control	NN
cord-288670-1vlowf2n	156	38	centre	centre	NN
cord-288670-1vlowf2n	156	39	for	for	IN
cord-288670-1vlowf2n	156	40	cellular	cellular	JJ
cord-288670-1vlowf2n	156	41	clearance	clearance	NN
cord-288670-1vlowf2n	156	42	and	and	CC
cord-288670-1vlowf2n	156	43	energy	energy	NN
cord-288670-1vlowf2n	156	44	metabolism	metabolism	NN
cord-288670-1vlowf2n	157	1	The	the	DT
cord-288670-1vlowf2n	157	2	lysosome	lysosome	NN
cord-288670-1vlowf2n	157	3	as	as	IN
cord-288670-1vlowf2n	157	4	a	a	DT
cord-288670-1vlowf2n	157	5	cellular	cellular	JJ
cord-288670-1vlowf2n	157	6	centre	centre	NN
cord-288670-1vlowf2n	157	7	for	for	IN
cord-288670-1vlowf2n	157	8	signalling	signal	VBG
cord-288670-1vlowf2n	157	9	,	,	,
cord-288670-1vlowf2n	157	10	metabolism	metabolism	NN
cord-288670-1vlowf2n	157	11	and	and	CC
cord-288670-1vlowf2n	157	12	quality	quality	NN
cord-288670-1vlowf2n	157	13	control	control	NN
cord-288670-1vlowf2n	158	1	Lysosomal	lysosomal	JJ
cord-288670-1vlowf2n	158	2	acidification	acidification	NN
cord-288670-1vlowf2n	158	3	mechanisms	mechanism	NNS
cord-288670-1vlowf2n	159	1	Proteomics	proteomic	NNS
cord-288670-1vlowf2n	159	2	of	of	IN
cord-288670-1vlowf2n	159	3	the	the	DT
cord-288670-1vlowf2n	159	4	lysosome	lysosome	NN
cord-288670-1vlowf2n	159	5	To	to	TO
cord-288670-1vlowf2n	159	6	degrade	degrade	VB
cord-288670-1vlowf2n	159	7	or	or	CC
cord-288670-1vlowf2n	159	8	not	not	RB
cord-288670-1vlowf2n	159	9	to	to	TO
cord-288670-1vlowf2n	159	10	degrade	degrade	VB
cord-288670-1vlowf2n	159	11	:	:	:
cord-288670-1vlowf2n	160	1	mechanisms	mechanism	NNS
cord-288670-1vlowf2n	160	2	and	and	CC
cord-288670-1vlowf2n	160	3	significance	significance	NN
cord-288670-1vlowf2n	160	4	of	of	IN
cord-288670-1vlowf2n	160	5	endocytic	endocytic	JJ
cord-288670-1vlowf2n	160	6	recycling	recycling	NN
cord-288670-1vlowf2n	160	7	The	the	DT
cord-288670-1vlowf2n	160	8	enigmatic	enigmatic	JJ
cord-288670-1vlowf2n	160	9	endosome	endosome	NN
cord-288670-1vlowf2n	160	10	-sorting	-sorte	VBG
cord-288670-1vlowf2n	160	11	the	the	DT
cord-288670-1vlowf2n	160	12	ins	in	NNS
cord-288670-1vlowf2n	160	13	and	and	CC
cord-288670-1vlowf2n	160	14	outs	out	NNS
cord-288670-1vlowf2n	160	15	of	of	IN
cord-288670-1vlowf2n	160	16	endocytic	endocytic	JJ
cord-288670-1vlowf2n	160	17	trafficking	traffic	VBG
cord-288670-1vlowf2n	160	18	Endocytic	Endocytic	NNP
cord-288670-1vlowf2n	160	19	membrane	membrane	NN
cord-288670-1vlowf2n	160	20	trafficking	trafficking	NN
cord-288670-1vlowf2n	160	21	and	and	CC
cord-288670-1vlowf2n	160	22	neurodegenerative	neurodegenerative	JJ
cord-288670-1vlowf2n	160	23	disease	disease	NN
cord-288670-1vlowf2n	160	24	Endosomal	Endosomal	NNP
cord-288670-1vlowf2n	160	25	vesicles	vesicle	NNS
cord-288670-1vlowf2n	160	26	as	as	IN
cord-288670-1vlowf2n	160	27	vehicles	vehicle	NNS
cord-288670-1vlowf2n	160	28	for	for	IN
cord-288670-1vlowf2n	160	29	viral	viral	JJ
cord-288670-1vlowf2n	160	30	genomes	genome	NNS
cord-288670-1vlowf2n	160	31	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	160	32	replication	replication	NN
cord-288670-1vlowf2n	160	33	complex	complex	JJ
cord-288670-1vlowf2n	160	34	formation	formation	NN
cord-288670-1vlowf2n	160	35	utilizes	utilize	VBZ
cord-288670-1vlowf2n	160	36	components	component	NNS
cord-288670-1vlowf2n	160	37	of	of	IN
cord-288670-1vlowf2n	160	38	cellular	cellular	JJ
cord-288670-1vlowf2n	160	39	autophagy	autophagy	NN
cord-288670-1vlowf2n	160	40	Identification	identification	NN
cord-288670-1vlowf2n	160	41	and	and	CC
cord-288670-1vlowf2n	160	42	characterization	characterization	NN
cord-288670-1vlowf2n	160	43	of	of	IN
cord-288670-1vlowf2n	160	44	severe	severe	JJ
cord-288670-1vlowf2n	160	45	acute	acute	JJ
cord-288670-1vlowf2n	160	46	respiratory	respiratory	JJ
cord-288670-1vlowf2n	160	47	syndrome	syndrome	NN
cord-288670-1vlowf2n	160	48	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	160	49	replicase	replicase	NN
cord-288670-1vlowf2n	160	50	proteins	protein	VBZ
cord-288670-1vlowf2n	160	51	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	160	52	nsp6	nsp6	NN
cord-288670-1vlowf2n	160	53	proteins	protein	NNS
cord-288670-1vlowf2n	160	54	generate	generate	VBP
cord-288670-1vlowf2n	160	55	autophagosomes	autophagosome	NNS
cord-288670-1vlowf2n	160	56	from	from	IN
cord-288670-1vlowf2n	160	57	the	the	DT
cord-288670-1vlowf2n	160	58	endoplasmic	endoplasmic	NN
cord-288670-1vlowf2n	160	59	reticulum	reticulum	NN
cord-288670-1vlowf2n	160	60	via	via	IN
cord-288670-1vlowf2n	160	61	an	an	DT
cord-288670-1vlowf2n	160	62	omegasome	omegasome	NN
cord-288670-1vlowf2n	160	63	intermediate	intermediate	JJ
cord-288670-1vlowf2n	160	64	Ultrastructure	Ultrastructure	NNP
cord-288670-1vlowf2n	160	65	and	and	CC
cord-288670-1vlowf2n	160	66	origin	origin	NN
cord-288670-1vlowf2n	160	67	of	of	IN
cord-288670-1vlowf2n	160	68	membrane	membrane	NN
cord-288670-1vlowf2n	160	69	vesicles	vesicle	NNS
cord-288670-1vlowf2n	160	70	associated	associate	VBN
cord-288670-1vlowf2n	160	71	with	with	IN
cord-288670-1vlowf2n	160	72	the	the	DT
cord-288670-1vlowf2n	160	73	severe	severe	JJ
cord-288670-1vlowf2n	160	74	acute	acute	JJ
cord-288670-1vlowf2n	160	75	respiratory	respiratory	JJ
cord-288670-1vlowf2n	160	76	syndrome	syndrome	NN
cord-288670-1vlowf2n	160	77	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	160	78	replication	replication	NN
cord-288670-1vlowf2n	160	79	complex	complex	JJ
cord-288670-1vlowf2n	160	80	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	160	81	replication	replication	NN
cord-288670-1vlowf2n	160	82	does	do	VBZ
cord-288670-1vlowf2n	160	83	not	not	RB
cord-288670-1vlowf2n	160	84	require	require	VB
cord-288670-1vlowf2n	160	85	the	the	DT
cord-288670-1vlowf2n	160	86	autophagy	autophagy	NN
cord-288670-1vlowf2n	160	87	gene	gene	NN
cord-288670-1vlowf2n	160	88	ATG5	ATG5	NNP
cord-288670-1vlowf2n	160	89	Coronaviruses	Coronaviruses	NNPS
cord-288670-1vlowf2n	160	90	Hijack	hijack	VBP
cord-288670-1vlowf2n	160	91	the	the	DT
cord-288670-1vlowf2n	160	92	LC3-I	lc3-i	NN
cord-288670-1vlowf2n	160	93	-	-	HYPH
cord-288670-1vlowf2n	160	94	positive	positive	JJ
cord-288670-1vlowf2n	160	95	EDEMosomes	edemosome	NNS
cord-288670-1vlowf2n	160	96	,	,	,
cord-288670-1vlowf2n	160	97	ER	ER	NNP
cord-288670-1vlowf2n	160	98	-	-	HYPH
cord-288670-1vlowf2n	160	99	derived	derive	VBN
cord-288670-1vlowf2n	160	100	vesicles	vesicle	NNS
cord-288670-1vlowf2n	160	101	exporting	export	VBG
cord-288670-1vlowf2n	160	102	short	short	RB
cord-288670-1vlowf2n	160	103	-	-	HYPH
cord-288670-1vlowf2n	160	104	lived	live	VBN
cord-288670-1vlowf2n	160	105	ERAD	ERAD	NNP
cord-288670-1vlowf2n	160	106	regulators	regulator	NNS
cord-288670-1vlowf2n	160	107	,	,	,
cord-288670-1vlowf2n	160	108	for	for	IN
cord-288670-1vlowf2n	160	109	replication	replication	NN
cord-288670-1vlowf2n	160	110	Severe	severe	JJ
cord-288670-1vlowf2n	160	111	acute	acute	JJ
cord-288670-1vlowf2n	160	112	respiratory	respiratory	JJ
cord-288670-1vlowf2n	160	113	syndrome	syndrome	NN
cord-288670-1vlowf2n	160	114	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	160	115	replication	replication	NN
cord-288670-1vlowf2n	160	116	is	be	VBZ
cord-288670-1vlowf2n	160	117	severely	severely	RB
cord-288670-1vlowf2n	160	118	impaired	impair	VBN
cord-288670-1vlowf2n	160	119	by	by	IN
cord-288670-1vlowf2n	160	120	MG132	mg132	NN
cord-288670-1vlowf2n	160	121	due	due	IN
cord-288670-1vlowf2n	160	122	to	to	IN
cord-288670-1vlowf2n	160	123	proteasome	proteasome	NN
cord-288670-1vlowf2n	160	124	-	-	HYPH
cord-288670-1vlowf2n	160	125	independent	independent	JJ
cord-288670-1vlowf2n	160	126	inhibition	inhibition	NN
cord-288670-1vlowf2n	160	127	of	of	IN
cord-288670-1vlowf2n	160	128	M	M	NNP
cord-288670-1vlowf2n	160	129	-	-	HYPH
cord-288670-1vlowf2n	160	130	calpain	calpain	VBN
cord-288670-1vlowf2n	160	131	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	160	132	membrane	membrane	NN
cord-288670-1vlowf2n	160	133	-	-	HYPH
cord-288670-1vlowf2n	160	134	associated	associate	VBN
cord-288670-1vlowf2n	160	135	papain	papain	NN
cord-288670-1vlowf2n	160	136	-	-	HYPH
cord-288670-1vlowf2n	160	137	like	like	JJ
cord-288670-1vlowf2n	160	138	proteases	protease	NNS
cord-288670-1vlowf2n	160	139	induce	induce	VBP
cord-288670-1vlowf2n	160	140	autophagy	autophagy	NN
cord-288670-1vlowf2n	160	141	through	through	IN
cord-288670-1vlowf2n	160	142	interacting	interact	VBG
cord-288670-1vlowf2n	160	143	with	with	IN
cord-288670-1vlowf2n	160	144	Beclin1	Beclin1	NNP
cord-288670-1vlowf2n	160	145	to	to	TO
cord-288670-1vlowf2n	160	146	negatively	negatively	RB
cord-288670-1vlowf2n	160	147	regulate	regulate	VB
cord-288670-1vlowf2n	160	148	antiviral	antiviral	JJ
cord-288670-1vlowf2n	160	149	innate	innate	JJ
cord-288670-1vlowf2n	160	150	immunity	immunity	NN
cord-288670-1vlowf2n	161	1	SKP2	SKP2	NNP
cord-288670-1vlowf2n	161	2	attenuates	attenuate	VBZ
cord-288670-1vlowf2n	161	3	autophagy	autophagy	NN
cord-288670-1vlowf2n	161	4	through	through	IN
cord-288670-1vlowf2n	161	5	Beclin1-ubiquitination	Beclin1-ubiquitination	NNP
cord-288670-1vlowf2n	161	6	and	and	CC
cord-288670-1vlowf2n	161	7	its	-PRON-	PRP$
cord-288670-1vlowf2n	161	8	inhibition	inhibition	NN
cord-288670-1vlowf2n	161	9	reduces	reduce	VBZ
cord-288670-1vlowf2n	161	10	MERS	MERS	NNP
cord-288670-1vlowf2n	161	11	-	-	HYPH
cord-288670-1vlowf2n	161	12	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	161	13	infection	infection	NN
cord-288670-1vlowf2n	162	1	Coronaviruses	Coronaviruses	NNP
cord-288670-1vlowf2n	162	2	-drug	-drug	NNP
cord-288670-1vlowf2n	162	3	discovery	discovery	NN
cord-288670-1vlowf2n	162	4	and	and	CC
cord-288670-1vlowf2n	162	5	therapeutic	therapeutic	JJ
cord-288670-1vlowf2n	162	6	options	option	NNS
cord-288670-1vlowf2n	163	1	Molecular	molecular	JJ
cord-288670-1vlowf2n	163	2	interactions	interaction	NNS
cord-288670-1vlowf2n	163	3	in	in	IN
cord-288670-1vlowf2n	163	4	the	the	DT
cord-288670-1vlowf2n	163	5	assembly	assembly	NN
cord-288670-1vlowf2n	163	6	of	of	IN
cord-288670-1vlowf2n	163	7	coronaviruses	coronaviruse	NNS
cord-288670-1vlowf2n	163	8	Physiological	physiological	JJ
cord-288670-1vlowf2n	163	9	and	and	CC
cord-288670-1vlowf2n	163	10	molecular	molecular	JJ
cord-288670-1vlowf2n	163	11	triggers	trigger	NNS
cord-288670-1vlowf2n	163	12	for	for	IN
cord-288670-1vlowf2n	163	13	SARS	SARS	NNP
cord-288670-1vlowf2n	163	14	-	-	HYPH
cord-288670-1vlowf2n	163	15	CoV	CoV	NNP
cord-288670-1vlowf2n	163	16	membrane	membrane	NN
cord-288670-1vlowf2n	163	17	fusion	fusion	NN
cord-288670-1vlowf2n	163	18	and	and	CC
cord-288670-1vlowf2n	163	19	entry	entry	NN
cord-288670-1vlowf2n	163	20	into	into	IN
cord-288670-1vlowf2n	163	21	host	host	NN
cord-288670-1vlowf2n	163	22	cells	cell	NNS
cord-288670-1vlowf2n	163	23	Significance	significance	NN
cord-288670-1vlowf2n	163	24	of	of	IN
cord-288670-1vlowf2n	163	25	lysosomes	lysosome	NNS
cord-288670-1vlowf2n	163	26	in	in	IN
cord-288670-1vlowf2n	163	27	the	the	DT
cord-288670-1vlowf2n	163	28	morphogenesis	morphogenesis	NN
cord-288670-1vlowf2n	163	29	of	of	IN
cord-288670-1vlowf2n	163	30	coronaviruses	coronaviruse	NNS
cord-288670-1vlowf2n	163	31	Infectious	Infectious	NNP
cord-288670-1vlowf2n	163	32	bronchitis	bronchitis	NN
cord-288670-1vlowf2n	163	33	virus	virus	NN
cord-288670-1vlowf2n	163	34	entry	entry	NN
cord-288670-1vlowf2n	163	35	mainly	mainly	RB
cord-288670-1vlowf2n	163	36	depends	depend	VBZ
cord-288670-1vlowf2n	163	37	on	on	IN
cord-288670-1vlowf2n	163	38	clathrin	clathrin	NN
cord-288670-1vlowf2n	163	39	mediated	mediate	VBN
cord-288670-1vlowf2n	163	40	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	163	41	and	and	CC
cord-288670-1vlowf2n	163	42	requires	require	VBZ
cord-288670-1vlowf2n	163	43	classical	classical	JJ
cord-288670-1vlowf2n	163	44	endosomal	endosomal	NNP
cord-288670-1vlowf2n	163	45	/	/	SYM
cord-288670-1vlowf2n	163	46	lysosomal	lysosomal	NN
cord-288670-1vlowf2n	163	47	system	system	NN
cord-288670-1vlowf2n	163	48	SARS	SARS	NNP
cord-288670-1vlowf2n	163	49	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	163	50	entry	entry	NN
cord-288670-1vlowf2n	163	51	into	into	IN
cord-288670-1vlowf2n	163	52	host	host	NN
cord-288670-1vlowf2n	163	53	cells	cell	NNS
cord-288670-1vlowf2n	163	54	through	through	IN
cord-288670-1vlowf2n	163	55	a	a	DT
cord-288670-1vlowf2n	163	56	novel	novel	JJ
cord-288670-1vlowf2n	163	57	clathrin	clathrin	NN
cord-288670-1vlowf2n	163	58	-	-	:
cord-288670-1vlowf2n	163	59	and	and	CC
cord-288670-1vlowf2n	163	60	caveolae	caveolae	JJ
cord-288670-1vlowf2n	163	61	-	-	HYPH
cord-288670-1vlowf2n	163	62	independent	independent	JJ
cord-288670-1vlowf2n	163	63	endocytic	endocytic	JJ
cord-288670-1vlowf2n	163	64	pathway	pathway	NN
cord-288670-1vlowf2n	163	65	Clathrin	Clathrin	NNP
cord-288670-1vlowf2n	163	66	-	-	HYPH
cord-288670-1vlowf2n	163	67	dependent	dependent	JJ
cord-288670-1vlowf2n	163	68	entry	entry	NN
cord-288670-1vlowf2n	163	69	of	of	IN
cord-288670-1vlowf2n	163	70	severe	severe	JJ
cord-288670-1vlowf2n	163	71	acute	acute	JJ
cord-288670-1vlowf2n	163	72	respiratory	respiratory	JJ
cord-288670-1vlowf2n	163	73	syndrome	syndrome	NN
cord-288670-1vlowf2n	163	74	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	163	75	into	into	IN
cord-288670-1vlowf2n	163	76	target	target	NN
cord-288670-1vlowf2n	163	77	cells	cell	NNS
cord-288670-1vlowf2n	163	78	expressing	express	VBG
cord-288670-1vlowf2n	163	79	ACE2	ACE2	NNP
cord-288670-1vlowf2n	163	80	with	with	IN
cord-288670-1vlowf2n	163	81	the	the	DT
cord-288670-1vlowf2n	163	82	cytoplasmic	cytoplasmic	JJ
cord-288670-1vlowf2n	163	83	tail	tail	NN
cord-288670-1vlowf2n	163	84	deleted	delete	VBD
cord-288670-1vlowf2n	163	85	A	a	DT
cord-288670-1vlowf2n	163	86	crucial	crucial	JJ
cord-288670-1vlowf2n	163	87	role	role	NN
cord-288670-1vlowf2n	163	88	of	of	IN
cord-288670-1vlowf2n	163	89	angiotensin	angiotensin	NN
cord-288670-1vlowf2n	163	90	converting	convert	VBG
cord-288670-1vlowf2n	163	91	enzyme	enzyme	NN
cord-288670-1vlowf2n	163	92	2	2	CD
cord-288670-1vlowf2n	163	93	(	(	-LRB-
cord-288670-1vlowf2n	163	94	ACE2	ACE2	NNP
cord-288670-1vlowf2n	163	95	)	)	-RRB-
cord-288670-1vlowf2n	163	96	in	in	IN
cord-288670-1vlowf2n	163	97	SARS	SARS	NNP
cord-288670-1vlowf2n	163	98	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	163	99	-	-	HYPH
cord-288670-1vlowf2n	163	100	induced	induce	VBN
cord-288670-1vlowf2n	163	101	lung	lung	NN
cord-288670-1vlowf2n	163	102	injury	injury	NN
cord-288670-1vlowf2n	163	103	A	a	NN
cord-288670-1vlowf2n	164	1	novel	novel	NNP
cord-288670-1vlowf2n	164	2	angiotensin	angiotensin	NN
cord-288670-1vlowf2n	164	3	-	-	HYPH
cord-288670-1vlowf2n	164	4	converting	convert	VBG
cord-288670-1vlowf2n	164	5	enzyme	enzyme	NN
cord-288670-1vlowf2n	164	6	-	-	HYPH
cord-288670-1vlowf2n	164	7	related	relate	VBN
cord-288670-1vlowf2n	164	8	carboxypeptidase	carboxypeptidase	NN
cord-288670-1vlowf2n	164	9	(	(	-LRB-
cord-288670-1vlowf2n	164	10	ACE2	ACE2	NNP
cord-288670-1vlowf2n	164	11	)	)	-RRB-
cord-288670-1vlowf2n	164	12	converts	convert	VBZ
cord-288670-1vlowf2n	164	13	angiotensin	angiotensin	NN
cord-288670-1vlowf2n	164	14	I	-PRON-	PRP
cord-288670-1vlowf2n	164	15	to	to	IN
cord-288670-1vlowf2n	164	16	angiotensin	angiotensin	NN
cord-288670-1vlowf2n	164	17	1	1	CD
cord-288670-1vlowf2n	164	18	-	-	SYM
cord-288670-1vlowf2n	164	19	9	9	CD
cord-288670-1vlowf2n	164	20	Tissue	tissue	NN
cord-288670-1vlowf2n	164	21	distribution	distribution	NN
cord-288670-1vlowf2n	164	22	of	of	IN
cord-288670-1vlowf2n	164	23	ACE2	ACE2	NNP
cord-288670-1vlowf2n	164	24	protein	protein	NN
cord-288670-1vlowf2n	164	25	,	,	,
cord-288670-1vlowf2n	164	26	the	the	DT
cord-288670-1vlowf2n	164	27	functional	functional	JJ
cord-288670-1vlowf2n	164	28	receptor	receptor	NN
cord-288670-1vlowf2n	164	29	for	for	IN
cord-288670-1vlowf2n	164	30	SARS	SARS	NNP
cord-288670-1vlowf2n	164	31	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	164	32	.	.	.
cord-288670-1vlowf2n	165	1	A	a	DT
cord-288670-1vlowf2n	165	2	first	first	JJ
cord-288670-1vlowf2n	165	3	step	step	NN
cord-288670-1vlowf2n	165	4	in	in	IN
cord-288670-1vlowf2n	165	5	understanding	understand	VBG
cord-288670-1vlowf2n	165	6	SARS	SARS	NNP
cord-288670-1vlowf2n	165	7	pathogenesis	pathogenesis	NN
cord-288670-1vlowf2n	165	8	Remdesivir	Remdesivir	NNP
cord-288670-1vlowf2n	165	9	and	and	CC
cord-288670-1vlowf2n	165	10	chloroquine	chloroquine	NN
cord-288670-1vlowf2n	165	11	effectively	effectively	RB
cord-288670-1vlowf2n	165	12	inhibit	inhibit	VBP
cord-288670-1vlowf2n	165	13	the	the	DT
cord-288670-1vlowf2n	165	14	recently	recently	RB
cord-288670-1vlowf2n	165	15	emerged	emerge	VBN
cord-288670-1vlowf2n	165	16	novel	novel	JJ
cord-288670-1vlowf2n	165	17	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	165	18	(	(	-LRB-
cord-288670-1vlowf2n	165	19	2019-nCoV	2019-ncov	CD
cord-288670-1vlowf2n	165	20	)	)	-RRB-
cord-288670-1vlowf2n	165	21	in	in	IN
cord-288670-1vlowf2n	165	22	vitro	vitro	FW
cord-288670-1vlowf2n	165	23	Localization	Localization	NNP
cord-288670-1vlowf2n	165	24	of	of	IN
cord-288670-1vlowf2n	165	25	mouse	mouse	NN
cord-288670-1vlowf2n	165	26	hepatitis	hepatitis	NN
cord-288670-1vlowf2n	165	27	virus	virus	NN
cord-288670-1vlowf2n	165	28	nonstructural	nonstructural	JJ
cord-288670-1vlowf2n	165	29	proteins	protein	NNS
cord-288670-1vlowf2n	165	30	and	and	CC
cord-288670-1vlowf2n	165	31	RNA	RNA	NNP
cord-288670-1vlowf2n	165	32	synthesis	synthesis	NN
cord-288670-1vlowf2n	165	33	indicates	indicate	VBZ
cord-288670-1vlowf2n	165	34	a	a	DT
cord-288670-1vlowf2n	165	35	role	role	NN
cord-288670-1vlowf2n	165	36	for	for	IN
cord-288670-1vlowf2n	165	37	late	late	JJ
cord-288670-1vlowf2n	165	38	endosomes	endosome	NNS
cord-288670-1vlowf2n	165	39	in	in	IN
cord-288670-1vlowf2n	165	40	viral	viral	JJ
cord-288670-1vlowf2n	165	41	replication	replication	NN
cord-288670-1vlowf2n	165	42	Characterization	characterization	NN
cord-288670-1vlowf2n	165	43	of	of	IN
cord-288670-1vlowf2n	165	44	severe	severe	JJ
cord-288670-1vlowf2n	165	45	acute	acute	JJ
cord-288670-1vlowf2n	165	46	respiratory	respiratory	JJ
cord-288670-1vlowf2n	165	47	syndrome	syndrome	NN
cord-288670-1vlowf2n	165	48	-	-	HYPH
cord-288670-1vlowf2n	165	49	associated	associate	VBN
cord-288670-1vlowf2n	165	50	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	165	51	(	(	-LRB-
cord-288670-1vlowf2n	165	52	SARS	SARS	NNP
cord-288670-1vlowf2n	165	53	-	-	HYPH
cord-288670-1vlowf2n	165	54	CoV	CoV	NNP
cord-288670-1vlowf2n	165	55	)	)	-RRB-
cord-288670-1vlowf2n	165	56	spike	spike	NN
cord-288670-1vlowf2n	165	57	glycoprotein	glycoprotein	NN
cord-288670-1vlowf2n	165	58	-	-	HYPH
cord-288670-1vlowf2n	165	59	mediated	mediate	VBN
cord-288670-1vlowf2n	165	60	viral	viral	JJ
cord-288670-1vlowf2n	165	61	entry	entry	NN
cord-288670-1vlowf2n	165	62	pH	ph	NN
cord-288670-1vlowf2n	165	63	-	-	HYPH
cord-288670-1vlowf2n	165	64	dependent	dependent	JJ
cord-288670-1vlowf2n	165	65	entry	entry	NN
cord-288670-1vlowf2n	165	66	of	of	IN
cord-288670-1vlowf2n	165	67	severe	severe	JJ
cord-288670-1vlowf2n	165	68	acute	acute	JJ
cord-288670-1vlowf2n	165	69	respiratory	respiratory	JJ
cord-288670-1vlowf2n	165	70	syndrome	syndrome	NN
cord-288670-1vlowf2n	165	71	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	165	72	is	be	VBZ
cord-288670-1vlowf2n	165	73	mediated	mediate	VBN
cord-288670-1vlowf2n	165	74	by	by	IN
cord-288670-1vlowf2n	165	75	the	the	DT
cord-288670-1vlowf2n	165	76	spike	spike	NN
cord-288670-1vlowf2n	165	77	glycoprotein	glycoprotein	NN
cord-288670-1vlowf2n	165	78	and	and	CC
cord-288670-1vlowf2n	165	79	enhanced	enhance	VBN
cord-288670-1vlowf2n	165	80	by	by	IN
cord-288670-1vlowf2n	165	81	dendritic	dendritic	JJ
cord-288670-1vlowf2n	165	82	cell	cell	NN
cord-288670-1vlowf2n	165	83	transfer	transfer	NN
cord-288670-1vlowf2n	165	84	through	through	IN
cord-288670-1vlowf2n	165	85	DC	DC	NNP
cord-288670-1vlowf2n	165	86	-	-	HYPH
cord-288670-1vlowf2n	165	87	SIGN	SIGN	NNP
cord-288670-1vlowf2n	165	88	Chloroquine	Chloroquine	NNP
cord-288670-1vlowf2n	165	89	is	be	VBZ
cord-288670-1vlowf2n	165	90	a	a	DT
cord-288670-1vlowf2n	165	91	potent	potent	JJ
cord-288670-1vlowf2n	165	92	inhibitor	inhibitor	NN
cord-288670-1vlowf2n	165	93	of	of	IN
cord-288670-1vlowf2n	165	94	SARS	SARS	NNP
cord-288670-1vlowf2n	165	95	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	165	96	infection	infection	NN
cord-288670-1vlowf2n	165	97	and	and	CC
cord-288670-1vlowf2n	165	98	spread	spread	VBD
cord-288670-1vlowf2n	165	99	SARS	SARS	NNP
cord-288670-1vlowf2n	165	100	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	165	101	,	,	,
cord-288670-1vlowf2n	165	102	but	but	CC
cord-288670-1vlowf2n	165	103	not	not	RB
cord-288670-1vlowf2n	165	104	human	human	JJ
cord-288670-1vlowf2n	165	105	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	166	1	NL63	NL63	NNP
cord-288670-1vlowf2n	166	2	,	,	,
cord-288670-1vlowf2n	166	3	utilizes	utilize	VBZ
cord-288670-1vlowf2n	166	4	cathepsin	cathepsin	NN
cord-288670-1vlowf2n	166	5	L	l	NN
cord-288670-1vlowf2n	166	6	to	to	TO
cord-288670-1vlowf2n	166	7	infect	infect	VB
cord-288670-1vlowf2n	166	8	ACE2-expressing	ace2-expressing	NN
cord-288670-1vlowf2n	166	9	cells	cell	NNS
cord-288670-1vlowf2n	167	1	Endosomal	Endosomal	NNP
cord-288670-1vlowf2n	167	2	proteolysis	proteolysis	NN
cord-288670-1vlowf2n	167	3	by	by	IN
cord-288670-1vlowf2n	167	4	cathepsins	cathepsin	NNS
cord-288670-1vlowf2n	167	5	is	be	VBZ
cord-288670-1vlowf2n	167	6	necessary	necessary	JJ
cord-288670-1vlowf2n	167	7	for	for	IN
cord-288670-1vlowf2n	167	8	murine	murine	JJ
cord-288670-1vlowf2n	167	9	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	167	10	mouse	mouse	NN
cord-288670-1vlowf2n	167	11	hepatitis	hepatitis	NN
cord-288670-1vlowf2n	167	12	virus	virus	NN
cord-288670-1vlowf2n	167	13	type	type	NN
cord-288670-1vlowf2n	167	14	2	2	CD
cord-288670-1vlowf2n	167	15	spike	spike	NN
cord-288670-1vlowf2n	167	16	-	-	HYPH
cord-288670-1vlowf2n	167	17	mediated	mediate	VBN
cord-288670-1vlowf2n	167	18	entry	entry	NN
cord-288670-1vlowf2n	167	19	Role	role	NN
cord-288670-1vlowf2n	167	20	of	of	IN
cord-288670-1vlowf2n	167	21	endocytosis	endocytosis	NN
cord-288670-1vlowf2n	167	22	and	and	CC
cord-288670-1vlowf2n	167	23	low	low	JJ
cord-288670-1vlowf2n	167	24	pH	ph	NN
cord-288670-1vlowf2n	167	25	in	in	IN
cord-288670-1vlowf2n	167	26	murine	murine	JJ
cord-288670-1vlowf2n	167	27	hepatitis	hepatitis	NN
cord-288670-1vlowf2n	167	28	virus	virus	NN
cord-288670-1vlowf2n	167	29	strain	strain	NN
cord-288670-1vlowf2n	167	30	A59	A59	NNP
cord-288670-1vlowf2n	167	31	cell	cell	NN
cord-288670-1vlowf2n	167	32	entry	entry	NN
cord-288670-1vlowf2n	168	1	Amiodarone	amiodarone	NN
cord-288670-1vlowf2n	168	2	alters	alter	VBZ
cord-288670-1vlowf2n	168	3	late	late	JJ
cord-288670-1vlowf2n	168	4	endosomes	endosome	NNS
cord-288670-1vlowf2n	168	5	and	and	CC
cord-288670-1vlowf2n	168	6	inhibits	inhibit	VBZ
cord-288670-1vlowf2n	168	7	SARS	SARS	NNP
cord-288670-1vlowf2n	168	8	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	168	9	infection	infection	NN
cord-288670-1vlowf2n	168	10	at	at	IN
cord-288670-1vlowf2n	168	11	a	a	DT
cord-288670-1vlowf2n	168	12	post	post	NN
cord-288670-1vlowf2n	168	13	-	-	JJ
cord-288670-1vlowf2n	168	14	endosomal	endosomal	JJ
cord-288670-1vlowf2n	168	15	level	level	NN
cord-288670-1vlowf2n	168	16	Mouse	Mouse	NNP
cord-288670-1vlowf2n	168	17	hepatitis	hepatitis	NN
cord-288670-1vlowf2n	168	18	virus	virus	NN
cord-288670-1vlowf2n	168	19	type	type	NN
cord-288670-1vlowf2n	168	20	2	2	CD
cord-288670-1vlowf2n	168	21	enters	enter	VBZ
cord-288670-1vlowf2n	168	22	cells	cell	NNS
cord-288670-1vlowf2n	168	23	through	through	IN
cord-288670-1vlowf2n	168	24	a	a	DT
cord-288670-1vlowf2n	168	25	clathrin	clathrin	NN
cord-288670-1vlowf2n	168	26	-	-	HYPH
cord-288670-1vlowf2n	168	27	mediated	mediate	VBN
cord-288670-1vlowf2n	168	28	endocytic	endocytic	JJ
cord-288670-1vlowf2n	168	29	pathway	pathway	NN
cord-288670-1vlowf2n	168	30	independent	independent	NN
cord-288670-1vlowf2n	168	31	of	of	IN
cord-288670-1vlowf2n	168	32	Eps15	Eps15	NNP
cord-288670-1vlowf2n	168	33	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	168	34	cell	cell	NN
cord-288670-1vlowf2n	168	35	entry	entry	NN
cord-288670-1vlowf2n	168	36	occurs	occur	VBZ
cord-288670-1vlowf2n	168	37	through	through	IN
cord-288670-1vlowf2n	168	38	the	the	DT
cord-288670-1vlowf2n	168	39	endo-/lysosomal	endo-/lysosomal	JJ
cord-288670-1vlowf2n	168	40	pathway	pathway	NN
cord-288670-1vlowf2n	168	41	in	in	IN
cord-288670-1vlowf2n	168	42	a	a	DT
cord-288670-1vlowf2n	168	43	proteolysis	proteolysis	NN
cord-288670-1vlowf2n	168	44	-	-	HYPH
cord-288670-1vlowf2n	168	45	dependent	dependent	JJ
cord-288670-1vlowf2n	168	46	manner	manner	NN
cord-288670-1vlowf2n	169	1	ATP1A1-mediated	ATP1A1-mediated	NNP
cord-288670-1vlowf2n	169	2	Src	Src	NNP
cord-288670-1vlowf2n	169	3	signaling	signaling	NN
cord-288670-1vlowf2n	169	4	inhibits	inhibit	VBZ
cord-288670-1vlowf2n	169	5	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	169	6	entry	entry	NN
cord-288670-1vlowf2n	169	7	into	into	IN
cord-288670-1vlowf2n	169	8	host	host	NN
cord-288670-1vlowf2n	169	9	cells	cell	NNS
cord-288670-1vlowf2n	170	1	Glycopeptide	Glycopeptide	NNP
cord-288670-1vlowf2n	170	2	Antibiotics	antibiotic	NNS
cord-288670-1vlowf2n	171	1	Potently	potently	RB
cord-288670-1vlowf2n	171	2	Inhibit	Inhibit	NNP
cord-288670-1vlowf2n	171	3	Cathepsin	Cathepsin	NNP
cord-288670-1vlowf2n	171	4	L	L	NNP
cord-288670-1vlowf2n	171	5	in	in	IN
cord-288670-1vlowf2n	171	6	the	the	DT
cord-288670-1vlowf2n	171	7	Late	Late	NNP
cord-288670-1vlowf2n	171	8	Endosome	Endosome	NNP
cord-288670-1vlowf2n	171	9	/	/	SYM
cord-288670-1vlowf2n	171	10	Lysosome	Lysosome	NNP
cord-288670-1vlowf2n	171	11	and	and	CC
cord-288670-1vlowf2n	171	12	Block	Block	NNP
cord-288670-1vlowf2n	171	13	the	the	DT
cord-288670-1vlowf2n	171	14	Entry	Entry	NNP
cord-288670-1vlowf2n	171	15	of	of	IN
cord-288670-1vlowf2n	171	16	Ebola	Ebola	NNP
cord-288670-1vlowf2n	171	17	Virus	Virus	NNP
cord-288670-1vlowf2n	171	18	,	,	,
cord-288670-1vlowf2n	171	19	Middle	Middle	NNP
cord-288670-1vlowf2n	171	20	East	East	NNP
cord-288670-1vlowf2n	171	21	Respiratory	Respiratory	NNP
cord-288670-1vlowf2n	171	22	Syndrome	Syndrome	NNP
cord-288670-1vlowf2n	171	23	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	171	24	(	(	-LRB-
cord-288670-1vlowf2n	171	25	MERS	MERS	NNP
cord-288670-1vlowf2n	171	26	-	-	HYPH
cord-288670-1vlowf2n	171	27	CoV	CoV	NNP
cord-288670-1vlowf2n	171	28	)	)	-RRB-
cord-288670-1vlowf2n	171	29	,	,	,
cord-288670-1vlowf2n	171	30	and	and	CC
cord-288670-1vlowf2n	171	31	Severe	severe	JJ
cord-288670-1vlowf2n	171	32	Acute	acute	JJ
cord-288670-1vlowf2n	171	33	Respiratory	Respiratory	NNP
cord-288670-1vlowf2n	171	34	Syndrome	Syndrome	NNP
cord-288670-1vlowf2n	171	35	Coronavirus	Coronavirus	NNP
cord-288670-1vlowf2n	171	36	(	(	-LRB-
cord-288670-1vlowf2n	171	37	SARS	SARS	NNP
cord-288670-1vlowf2n	171	38	-	-	HYPH
cord-288670-1vlowf2n	171	39	CoV	CoV	NNP
cord-288670-1vlowf2n	171	40	)	)	-RRB-
cord-288670-1vlowf2n	172	1	Proteolytic	proteolytic	JJ
cord-288670-1vlowf2n	172	2	processing	processing	NN
cord-288670-1vlowf2n	172	3	of	of	IN
cord-288670-1vlowf2n	172	4	Middle	Middle	NNP
cord-288670-1vlowf2n	172	5	East	East	NNP
cord-288670-1vlowf2n	172	6	respiratory	respiratory	JJ
cord-288670-1vlowf2n	172	7	syndrome	syndrome	NN
cord-288670-1vlowf2n	172	8	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	172	9	spikes	spike	NNS
cord-288670-1vlowf2n	172	10	expands	expand	VBZ
cord-288670-1vlowf2n	172	11	virus	virus	NN
cord-288670-1vlowf2n	172	12	tropism	tropism	NN
cord-288670-1vlowf2n	172	13	Akt	Akt	NNP
cord-288670-1vlowf2n	172	14	inhibition	inhibition	NN
cord-288670-1vlowf2n	172	15	promotes	promote	VBZ
cord-288670-1vlowf2n	172	16	autophagy	autophagy	NN
cord-288670-1vlowf2n	172	17	and	and	CC
cord-288670-1vlowf2n	172	18	sensitizes	sensitize	VBZ
cord-288670-1vlowf2n	172	19	PTEN	PTEN	NNP
cord-288670-1vlowf2n	172	20	-	-	HYPH
cord-288670-1vlowf2n	172	21	null	null	JJ
cord-288670-1vlowf2n	172	22	tumors	tumor	NNS
cord-288670-1vlowf2n	172	23	to	to	IN
cord-288670-1vlowf2n	172	24	lysosomotropic	lysosomotropic	JJ
cord-288670-1vlowf2n	172	25	agents	agent	NNS
cord-288670-1vlowf2n	172	26	New	new	JJ
cord-288670-1vlowf2n	172	27	insights	insight	NNS
cord-288670-1vlowf2n	172	28	into	into	IN
cord-288670-1vlowf2n	172	29	the	the	DT
cord-288670-1vlowf2n	172	30	antiviral	antiviral	JJ
cord-288670-1vlowf2n	172	31	effects	effect	NNS
cord-288670-1vlowf2n	172	32	of	of	IN
cord-288670-1vlowf2n	172	33	chloroquine	chloroquine	NN
cord-288670-1vlowf2n	172	34	Targeting	target	VBG
cord-288670-1vlowf2n	172	35	endosomal	endosomal	JJ
cord-288670-1vlowf2n	172	36	acidification	acidification	NN
cord-288670-1vlowf2n	172	37	by	by	IN
cord-288670-1vlowf2n	172	38	chloroquine	chloroquine	NN
cord-288670-1vlowf2n	172	39	analogs	analog	NNS
cord-288670-1vlowf2n	172	40	as	as	IN
cord-288670-1vlowf2n	172	41	a	a	DT
cord-288670-1vlowf2n	172	42	promising	promising	JJ
cord-288670-1vlowf2n	172	43	strategy	strategy	NN
cord-288670-1vlowf2n	172	44	for	for	IN
cord-288670-1vlowf2n	172	45	the	the	DT
cord-288670-1vlowf2n	172	46	treatment	treatment	NN
cord-288670-1vlowf2n	172	47	of	of	IN
cord-288670-1vlowf2n	172	48	emerging	emerge	VBG
cord-288670-1vlowf2n	172	49	viral	viral	JJ
cord-288670-1vlowf2n	172	50	diseases	disease	NNS
cord-288670-1vlowf2n	172	51	Screening	screening	NN
cord-288670-1vlowf2n	172	52	of	of	IN
cord-288670-1vlowf2n	172	53	an	an	DT
cord-288670-1vlowf2n	172	54	FDA	FDA	NNP
cord-288670-1vlowf2n	172	55	-	-	HYPH
cord-288670-1vlowf2n	172	56	approved	approve	VBN
cord-288670-1vlowf2n	172	57	compound	compound	NN
cord-288670-1vlowf2n	172	58	library	library	NN
cord-288670-1vlowf2n	172	59	identifies	identify	VBZ
cord-288670-1vlowf2n	172	60	four	four	CD
cord-288670-1vlowf2n	172	61	small	small	JJ
cord-288670-1vlowf2n	172	62	-	-	HYPH
cord-288670-1vlowf2n	172	63	molecule	molecule	NN
cord-288670-1vlowf2n	172	64	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	172	65	of	of	IN
cord-288670-1vlowf2n	172	66	Middle	Middle	NNP
cord-288670-1vlowf2n	172	67	East	East	NNP
cord-288670-1vlowf2n	172	68	respiratory	respiratory	JJ
cord-288670-1vlowf2n	172	69	syndrome	syndrome	NN
cord-288670-1vlowf2n	172	70	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	172	71	replication	replication	NN
cord-288670-1vlowf2n	172	72	in	in	IN
cord-288670-1vlowf2n	172	73	cell	cell	NN
cord-288670-1vlowf2n	172	74	culture	culture	NN
cord-288670-1vlowf2n	172	75	Identification	identification	NN
cord-288670-1vlowf2n	172	76	of	of	IN
cord-288670-1vlowf2n	172	77	a	a	DT
cord-288670-1vlowf2n	172	78	lysosomal	lysosomal	JJ
cord-288670-1vlowf2n	172	79	pathway	pathway	NN
cord-288670-1vlowf2n	172	80	that	that	WDT
cord-288670-1vlowf2n	172	81	modulates	modulate	VBZ
cord-288670-1vlowf2n	172	82	glucocorticoid	glucocorticoid	NN
cord-288670-1vlowf2n	172	83	signaling	signaling	NN
cord-288670-1vlowf2n	172	84	and	and	CC
cord-288670-1vlowf2n	172	85	the	the	DT
cord-288670-1vlowf2n	172	86	inflammatory	inflammatory	JJ
cord-288670-1vlowf2n	172	87	response	response	NN
cord-288670-1vlowf2n	173	1	Advances	advance	NNS
cord-288670-1vlowf2n	173	2	in	in	IN
cord-288670-1vlowf2n	173	3	clinical	clinical	JJ
cord-288670-1vlowf2n	173	4	diagnosis	diagnosis	NN
cord-288670-1vlowf2n	173	5	and	and	CC
cord-288670-1vlowf2n	173	6	treatment	treatment	NN
cord-288670-1vlowf2n	173	7	of	of	IN
cord-288670-1vlowf2n	173	8	severe	severe	JJ
cord-288670-1vlowf2n	173	9	acute	acute	JJ
cord-288670-1vlowf2n	173	10	respiratory	respiratory	JJ
cord-288670-1vlowf2n	173	11	syndrome	syndrome	NN
cord-288670-1vlowf2n	173	12	Breakthrough	Breakthrough	NNP
cord-288670-1vlowf2n	174	1	:	:	:
cord-288670-1vlowf2n	174	2	Chloroquine	chloroquine	NN
cord-288670-1vlowf2n	174	3	phosphate	phosphate	NN
cord-288670-1vlowf2n	174	4	has	have	VBZ
cord-288670-1vlowf2n	174	5	shown	show	VBN
cord-288670-1vlowf2n	174	6	apparent	apparent	JJ
cord-288670-1vlowf2n	174	7	efficacy	efficacy	NN
cord-288670-1vlowf2n	174	8	in	in	IN
cord-288670-1vlowf2n	174	9	treatment	treatment	NN
cord-288670-1vlowf2n	174	10	of	of	IN
cord-288670-1vlowf2n	174	11	COVID-19	covid-19	JJ
cord-288670-1vlowf2n	174	12	associated	associated	JJ
cord-288670-1vlowf2n	174	13	pneumonia	pneumonia	NN
cord-288670-1vlowf2n	174	14	in	in	IN
cord-288670-1vlowf2n	174	15	clinical	clinical	JJ
cord-288670-1vlowf2n	174	16	studies	study	NNS
cord-288670-1vlowf2n	174	17	Mechanisms	Mechanisms	NNPS
cord-288670-1vlowf2n	174	18	of	of	IN
cord-288670-1vlowf2n	174	19	action	action	NN
cord-288670-1vlowf2n	174	20	of	of	IN
cord-288670-1vlowf2n	174	21	hydroxychloroquine	hydroxychloroquine	NNP
cord-288670-1vlowf2n	174	22	and	and	CC
cord-288670-1vlowf2n	174	23	chloroquine	chloroquine	NN
cord-288670-1vlowf2n	174	24	:	:	:
cord-288670-1vlowf2n	174	25	implications	implication	NNS
cord-288670-1vlowf2n	174	26	for	for	IN
cord-288670-1vlowf2n	174	27	rheumatology	rheumatology	NNP
cord-288670-1vlowf2n	174	28	Health	Health	NNP
cord-288670-1vlowf2n	174	29	Commission	Commission	NNP
cord-288670-1vlowf2n	174	30	of	of	IN
cord-288670-1vlowf2n	174	31	Guangdong	Guangdong	NNP
cord-288670-1vlowf2n	174	32	Province	Province	NNP
cord-288670-1vlowf2n	174	33	for	for	IN
cord-288670-1vlowf2n	174	34	chloroquine	chloroquine	NN
cord-288670-1vlowf2n	174	35	in	in	IN
cord-288670-1vlowf2n	174	36	the	the	DT
cord-288670-1vlowf2n	174	37	treatment	treatment	NN
cord-288670-1vlowf2n	174	38	of	of	IN
cord-288670-1vlowf2n	174	39	novel	novel	JJ
cord-288670-1vlowf2n	174	40	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	174	41	p	p	NN
cord-288670-1vlowf2n	174	42	Protease	protease	NN
cord-288670-1vlowf2n	174	43	inhibitors	inhibitor	NNS
cord-288670-1vlowf2n	174	44	targeting	target	VBG
cord-288670-1vlowf2n	174	45	coronavirus	coronavirus	NN
cord-288670-1vlowf2n	174	46	and	and	CC
cord-288670-1vlowf2n	174	47	filovirus	filovirus	NN
cord-288670-1vlowf2n	174	48	entry	entry	NN
cord-288670-1vlowf2n	174	49	SARS	SARS	NNP
cord-288670-1vlowf2n	174	50	-	-	HYPH
cord-288670-1vlowf2n	174	51	CoV-2	CoV-2	NNP
cord-288670-1vlowf2n	174	52	cell	cell	NN
cord-288670-1vlowf2n	174	53	entry	entry	NN
cord-288670-1vlowf2n	174	54	depends	depend	VBZ
cord-288670-1vlowf2n	174	55	on	on	IN
cord-288670-1vlowf2n	174	56	ACE2	ACE2	NNP
cord-288670-1vlowf2n	174	57	and	and	CC
cord-288670-1vlowf2n	174	58	TMPRSS2	TMPRSS2	NNP
cord-288670-1vlowf2n	174	59	and	and	CC
cord-288670-1vlowf2n	174	60	is	be	VBZ
cord-288670-1vlowf2n	174	61	blocked	block	VBN
cord-288670-1vlowf2n	174	62	by	by	IN
cord-288670-1vlowf2n	174	63	a	a	DT
cord-288670-1vlowf2n	174	64	2	2	CD
cord-288670-1vlowf2n	174	65	clinically	clinically	RB
cord-288670-1vlowf2n	174	66	-	-	HYPH
cord-288670-1vlowf2n	174	67	proven	prove	VBN
cord-288670-1vlowf2n	174	68	protease	protease	NN
cord-288670-1vlowf2n	174	69	inhibitor	inhibitor	NN
cord-288670-1vlowf2n	174	70	Cell	cell	NN
cord-288670-1vlowf2n	174	71	Classics	Classics	NNPS
cord-288670-1vlowf2n	174	72	in	in	IN
cord-288670-1vlowf2n	174	73	Chemical	Chemical	NNP
cord-288670-1vlowf2n	174	74	Neuroscience	Neuroscience	NNP
cord-288670-1vlowf2n	174	75	:	:	:
cord-288670-1vlowf2n	175	1	Chlorpromazine	Chlorpromazine	NNP
cord-288670-1vlowf2n	176	1	The	the	DT
cord-288670-1vlowf2n	176	2	authors	author	NNS
cord-288670-1vlowf2n	176	3	have	have	VBP
cord-288670-1vlowf2n	176	4	declared	declare	VBN
cord-288670-1vlowf2n	176	5	that	that	IN
cord-288670-1vlowf2n	176	6	no	no	DT
cord-288670-1vlowf2n	176	7	competing	compete	VBG
cord-288670-1vlowf2n	176	8	interest	interest	NN
cord-288670-1vlowf2n	176	9	exists	exist	VBZ
cord-288670-1vlowf2n	176	10	.	.	.