id sid tid token lemma pos cord-280624-7v8xuicg 1 1 key key JJ cord-280624-7v8xuicg 1 2 : : : cord-280624-7v8xuicg 1 3 cord-280624 cord-280624 NNP cord-280624-7v8xuicg 1 4 - - HYPH cord-280624-7v8xuicg 1 5 7v8xuicg 7v8xuicg NNP cord-280624-7v8xuicg 2 1 authors author NNS cord-280624-7v8xuicg 2 2 : : : cord-280624-7v8xuicg 3 1 Ba Ba NNP cord-280624-7v8xuicg 3 2 Abduallah Abduallah NNP cord-280624-7v8xuicg 3 3 , , , cord-280624-7v8xuicg 3 4 Mohamed Mohamed NNP cord-280624-7v8xuicg 3 5 M. M. NNP cord-280624-7v8xuicg 3 6 ; ; : cord-280624-7v8xuicg 3 7 Hemida Hemida NNP cord-280624-7v8xuicg 3 8 , , , cord-280624-7v8xuicg 3 9 Maged Maged NNP cord-280624-7v8xuicg 3 10 Gomaa Gomaa NNP cord-280624-7v8xuicg 3 11 title title NN cord-280624-7v8xuicg 3 12 : : : cord-280624-7v8xuicg 3 13 Comparative comparative JJ cord-280624-7v8xuicg 3 14 analysis analysis NN cord-280624-7v8xuicg 3 15 of of IN cord-280624-7v8xuicg 3 16 the the DT cord-280624-7v8xuicg 3 17 genome genome NN cord-280624-7v8xuicg 3 18 structure structure NN cord-280624-7v8xuicg 3 19 and and CC cord-280624-7v8xuicg 3 20 organization organization NN cord-280624-7v8xuicg 3 21 of of IN cord-280624-7v8xuicg 3 22 the the DT cord-280624-7v8xuicg 3 23 Middle Middle NNP cord-280624-7v8xuicg 3 24 East East NNP cord-280624-7v8xuicg 3 25 respiratory respiratory JJ cord-280624-7v8xuicg 3 26 syndrome syndrome NN cord-280624-7v8xuicg 3 27 coronavirus coronavirus NN cord-280624-7v8xuicg 3 28 ( ( -LRB- cord-280624-7v8xuicg 3 29 MERS‐CoV MERS‐CoV NNP cord-280624-7v8xuicg 3 30 ) ) -RRB- cord-280624-7v8xuicg 3 31 2012 2012 CD cord-280624-7v8xuicg 3 32 to to IN cord-280624-7v8xuicg 3 33 2019 2019 CD cord-280624-7v8xuicg 3 34 revealing reveal VBG cord-280624-7v8xuicg 3 35 evidence evidence NN cord-280624-7v8xuicg 3 36 for for IN cord-280624-7v8xuicg 3 37 virus virus NN cord-280624-7v8xuicg 3 38 strain strain NN cord-280624-7v8xuicg 3 39 barcoding barcoding NN cord-280624-7v8xuicg 3 40 , , , cord-280624-7v8xuicg 3 41 zoonotic zoonotic JJ cord-280624-7v8xuicg 3 42 transmission transmission NN cord-280624-7v8xuicg 3 43 , , , cord-280624-7v8xuicg 3 44 and and CC cord-280624-7v8xuicg 3 45 selection selection NN cord-280624-7v8xuicg 3 46 pressure pressure NN cord-280624-7v8xuicg 3 47 date date NN cord-280624-7v8xuicg 3 48 : : : cord-280624-7v8xuicg 3 49 2020 2020 CD cord-280624-7v8xuicg 3 50 - - HYPH cord-280624-7v8xuicg 3 51 08 08 CD cord-280624-7v8xuicg 3 52 - - SYM cord-280624-7v8xuicg 3 53 17 17 CD cord-280624-7v8xuicg 3 54 journal journal NN cord-280624-7v8xuicg 3 55 : : : cord-280624-7v8xuicg 4 1 Rev Rev NNP cord-280624-7v8xuicg 4 2 Med Med NNP cord-280624-7v8xuicg 4 3 Virol Virol NNP cord-280624-7v8xuicg 4 4 DOI doi NN cord-280624-7v8xuicg 4 5 : : : cord-280624-7v8xuicg 5 1 10.1002 10.1002 CD cord-280624-7v8xuicg 5 2 / / SYM cord-280624-7v8xuicg 5 3 rmv.2150 rmv.2150 NNP cord-280624-7v8xuicg 5 4 sha sha NNP cord-280624-7v8xuicg 5 5 : : : cord-280624-7v8xuicg 5 6 0828560559e36382418947f10446d915c514e01e 0828560559e36382418947f10446d915c514e01e NFP cord-280624-7v8xuicg 5 7 doc_id doc_id CD cord-280624-7v8xuicg 6 1 : : : cord-280624-7v8xuicg 6 2 280624 280624 CD cord-280624-7v8xuicg 6 3 cord_uid cord_uid NNS cord-280624-7v8xuicg 6 4 : : : cord-280624-7v8xuicg 6 5 7v8xuicg 7v8xuicg LS cord-280624-7v8xuicg 7 1 The the DT cord-280624-7v8xuicg 7 2 Middle Middle NNP cord-280624-7v8xuicg 7 3 East East NNP cord-280624-7v8xuicg 7 4 respiratory respiratory JJ cord-280624-7v8xuicg 7 5 syndrome syndrome NN cord-280624-7v8xuicg 7 6 coronavirus coronavirus NN cord-280624-7v8xuicg 7 7 ( ( -LRB- cord-280624-7v8xuicg 7 8 MERS‐CoV MERS‐CoV NNP cord-280624-7v8xuicg 7 9 ) ) -RRB- cord-280624-7v8xuicg 7 10 emerged emerge VBD cord-280624-7v8xuicg 7 11 in in IN cord-280624-7v8xuicg 7 12 late late JJ cord-280624-7v8xuicg 7 13 2012 2012 CD cord-280624-7v8xuicg 7 14 in in IN cord-280624-7v8xuicg 7 15 Saudi Saudi NNP cord-280624-7v8xuicg 7 16 Arabia Arabia NNP cord-280624-7v8xuicg 7 17 . . . cord-280624-7v8xuicg 8 1 For for IN cord-280624-7v8xuicg 8 2 this this DT cord-280624-7v8xuicg 8 3 study study NN cord-280624-7v8xuicg 8 4 , , , cord-280624-7v8xuicg 8 5 we -PRON- PRP cord-280624-7v8xuicg 8 6 conducted conduct VBD cord-280624-7v8xuicg 8 7 a a DT cord-280624-7v8xuicg 8 8 large‐scale large‐scale NNP cord-280624-7v8xuicg 8 9 comparative comparative JJ cord-280624-7v8xuicg 8 10 genome genome NN cord-280624-7v8xuicg 8 11 study study NN cord-280624-7v8xuicg 8 12 of of IN cord-280624-7v8xuicg 8 13 MERS‐CoV MERS‐CoV NNP cord-280624-7v8xuicg 8 14 from from IN cord-280624-7v8xuicg 8 15 both both CC cord-280624-7v8xuicg 8 16 human human JJ cord-280624-7v8xuicg 8 17 and and CC cord-280624-7v8xuicg 8 18 dromedary dromedary NN cord-280624-7v8xuicg 8 19 camels camel NNS cord-280624-7v8xuicg 8 20 from from IN cord-280624-7v8xuicg 8 21 2012 2012 CD cord-280624-7v8xuicg 8 22 to to IN cord-280624-7v8xuicg 8 23 2019 2019 CD cord-280624-7v8xuicg 8 24 to to TO cord-280624-7v8xuicg 8 25 map map VB cord-280624-7v8xuicg 8 26 any any DT cord-280624-7v8xuicg 8 27 genetic genetic JJ cord-280624-7v8xuicg 8 28 changes change NNS cord-280624-7v8xuicg 8 29 that that WDT cord-280624-7v8xuicg 8 30 emerged emerge VBD cord-280624-7v8xuicg 8 31 in in IN cord-280624-7v8xuicg 8 32 the the DT cord-280624-7v8xuicg 8 33 past past JJ cord-280624-7v8xuicg 8 34 8 8 CD cord-280624-7v8xuicg 8 35 years year NNS cord-280624-7v8xuicg 8 36 . . . cord-280624-7v8xuicg 9 1 We -PRON- PRP cord-280624-7v8xuicg 9 2 downloaded download VBD cord-280624-7v8xuicg 9 3 1309 1309 CD cord-280624-7v8xuicg 9 4 submissions submission NNS cord-280624-7v8xuicg 9 5 , , , cord-280624-7v8xuicg 9 6 including include VBG cord-280624-7v8xuicg 9 7 308 308 CD cord-280624-7v8xuicg 9 8 full‐length full‐length NNP cord-280624-7v8xuicg 9 9 genome genome NN cord-280624-7v8xuicg 9 10 sequences sequence NNS cord-280624-7v8xuicg 9 11 of of IN cord-280624-7v8xuicg 9 12 MERS‐CoV MERS‐CoV NNP cord-280624-7v8xuicg 9 13 available available JJ cord-280624-7v8xuicg 9 14 in in IN cord-280624-7v8xuicg 9 15 GenBank GenBank NNP cord-280624-7v8xuicg 9 16 from from IN cord-280624-7v8xuicg 9 17 2012 2012 CD cord-280624-7v8xuicg 9 18 to to IN cord-280624-7v8xuicg 9 19 2019 2019 CD cord-280624-7v8xuicg 9 20 . . . cord-280624-7v8xuicg 10 1 We -PRON- PRP cord-280624-7v8xuicg 10 2 used use VBD cord-280624-7v8xuicg 10 3 bioinformatics bioinformatics NN cord-280624-7v8xuicg 10 4 tools tool NNS cord-280624-7v8xuicg 10 5 to to TO cord-280624-7v8xuicg 10 6 describe describe VB cord-280624-7v8xuicg 10 7 the the DT cord-280624-7v8xuicg 10 8 genome genome NN cord-280624-7v8xuicg 10 9 structure structure NN cord-280624-7v8xuicg 10 10 and and CC cord-280624-7v8xuicg 10 11 organization organization NN cord-280624-7v8xuicg 10 12 of of IN cord-280624-7v8xuicg 10 13 the the DT cord-280624-7v8xuicg 10 14 virus virus NN cord-280624-7v8xuicg 10 15 and and CC cord-280624-7v8xuicg 10 16 to to TO cord-280624-7v8xuicg 10 17 map map VB cord-280624-7v8xuicg 10 18 the the DT cord-280624-7v8xuicg 10 19 most most RBS cord-280624-7v8xuicg 10 20 important important JJ cord-280624-7v8xuicg 10 21 motifs motif NNS cord-280624-7v8xuicg 10 22 within within IN cord-280624-7v8xuicg 10 23 various various JJ cord-280624-7v8xuicg 10 24 regions region NNS cord-280624-7v8xuicg 10 25 / / SYM cord-280624-7v8xuicg 10 26 genes gene NNS cord-280624-7v8xuicg 10 27 throughout throughout IN cord-280624-7v8xuicg 10 28 the the DT cord-280624-7v8xuicg 10 29 genome genome NN cord-280624-7v8xuicg 10 30 over over IN cord-280624-7v8xuicg 10 31 the the DT cord-280624-7v8xuicg 10 32 past past JJ cord-280624-7v8xuicg 10 33 8 8 CD cord-280624-7v8xuicg 10 34 years year NNS cord-280624-7v8xuicg 10 35 . . . cord-280624-7v8xuicg 11 1 We -PRON- PRP cord-280624-7v8xuicg 11 2 also also RB cord-280624-7v8xuicg 11 3 monitored monitor VBD cord-280624-7v8xuicg 11 4 variations variation NNS cord-280624-7v8xuicg 11 5 / / SYM cord-280624-7v8xuicg 11 6 mutations mutation NNS cord-280624-7v8xuicg 11 7 among among IN cord-280624-7v8xuicg 11 8 these these DT cord-280624-7v8xuicg 11 9 sequences sequence NNS cord-280624-7v8xuicg 11 10 since since IN cord-280624-7v8xuicg 11 11 its -PRON- PRP$ cord-280624-7v8xuicg 11 12 emergence emergence NN cord-280624-7v8xuicg 11 13 . . . cord-280624-7v8xuicg 12 1 Our -PRON- PRP$ cord-280624-7v8xuicg 12 2 phylogenetic phylogenetic JJ cord-280624-7v8xuicg 12 3 analyses analysis NNS cord-280624-7v8xuicg 12 4 suggest suggest VBP cord-280624-7v8xuicg 12 5 that that IN cord-280624-7v8xuicg 12 6 the the DT cord-280624-7v8xuicg 12 7 cluster cluster NN cord-280624-7v8xuicg 12 8 within within IN cord-280624-7v8xuicg 12 9 African african JJ cord-280624-7v8xuicg 12 10 camels camel NNS cord-280624-7v8xuicg 12 11 is be VBZ cord-280624-7v8xuicg 12 12 derived derive VBN cord-280624-7v8xuicg 12 13 by by IN cord-280624-7v8xuicg 12 14 S S NNP cord-280624-7v8xuicg 12 15 gene gene NN cord-280624-7v8xuicg 12 16 . . . cord-280624-7v8xuicg 13 1 We -PRON- PRP cord-280624-7v8xuicg 13 2 identified identify VBD cord-280624-7v8xuicg 13 3 some some DT cord-280624-7v8xuicg 13 4 prominent prominent JJ cord-280624-7v8xuicg 13 5 motifs motif NNS cord-280624-7v8xuicg 13 6 within within IN cord-280624-7v8xuicg 13 7 the the DT cord-280624-7v8xuicg 13 8 ORF1ab ORF1ab NNP cord-280624-7v8xuicg 13 9 , , , cord-280624-7v8xuicg 13 10 S S NNP cord-280624-7v8xuicg 13 11 gene gene NN cord-280624-7v8xuicg 13 12 and and CC cord-280624-7v8xuicg 13 13 ORF‐5 ORF‐5 NNP cord-280624-7v8xuicg 13 14 , , , cord-280624-7v8xuicg 13 15 which which WDT cord-280624-7v8xuicg 13 16 may may MD cord-280624-7v8xuicg 13 17 be be VB cord-280624-7v8xuicg 13 18 used use VBN cord-280624-7v8xuicg 13 19 for for IN cord-280624-7v8xuicg 13 20 barcoding barcoding NN cord-280624-7v8xuicg 13 21 the the DT cord-280624-7v8xuicg 13 22 African african JJ cord-280624-7v8xuicg 13 23 camel camel NN cord-280624-7v8xuicg 13 24 lineages lineage NNS cord-280624-7v8xuicg 13 25 of of IN cord-280624-7v8xuicg 13 26 MERS‐CoV. mers‐cov. NN cord-280624-7v8xuicg 14 1 Furthermore furthermore RB cord-280624-7v8xuicg 14 2 , , , cord-280624-7v8xuicg 14 3 we -PRON- PRP cord-280624-7v8xuicg 14 4 mapped map VBD cord-280624-7v8xuicg 14 5 some some DT cord-280624-7v8xuicg 14 6 sequence sequence NN cord-280624-7v8xuicg 14 7 patterns pattern NNS cord-280624-7v8xuicg 14 8 that that WDT cord-280624-7v8xuicg 14 9 support support VBP cord-280624-7v8xuicg 14 10 the the DT cord-280624-7v8xuicg 14 11 zoonotic zoonotic JJ cord-280624-7v8xuicg 14 12 origin origin NN cord-280624-7v8xuicg 14 13 of of IN cord-280624-7v8xuicg 14 14 the the DT cord-280624-7v8xuicg 14 15 virus virus NN cord-280624-7v8xuicg 14 16 from from IN cord-280624-7v8xuicg 14 17 dromedary dromedary NN cord-280624-7v8xuicg 14 18 camels camel NNS cord-280624-7v8xuicg 14 19 . . . cord-280624-7v8xuicg 15 1 Other other JJ cord-280624-7v8xuicg 15 2 sequences sequence NNS cord-280624-7v8xuicg 15 3 identified identify VBD cord-280624-7v8xuicg 15 4 selection selection NN cord-280624-7v8xuicg 15 5 pressures pressure NNS cord-280624-7v8xuicg 15 6 , , , cord-280624-7v8xuicg 15 7 particularly particularly RB cord-280624-7v8xuicg 15 8 within within IN cord-280624-7v8xuicg 15 9 the the DT cord-280624-7v8xuicg 15 10 N n CD cord-280624-7v8xuicg 15 11 gene gene NN cord-280624-7v8xuicg 15 12 and and CC cord-280624-7v8xuicg 15 13 the the DT cord-280624-7v8xuicg 15 14 5′ 5′ CD cord-280624-7v8xuicg 15 15 UTR UTR NNP cord-280624-7v8xuicg 15 16 . . . cord-280624-7v8xuicg 16 1 Further further JJ cord-280624-7v8xuicg 16 2 studies study NNS cord-280624-7v8xuicg 16 3 are be VBP cord-280624-7v8xuicg 16 4 required require VBN cord-280624-7v8xuicg 16 5 for for IN cord-280624-7v8xuicg 16 6 careful careful JJ cord-280624-7v8xuicg 16 7 monitoring monitoring NN cord-280624-7v8xuicg 16 8 of of IN cord-280624-7v8xuicg 16 9 the the DT cord-280624-7v8xuicg 16 10 MERS‐CoV MERS‐CoV NNP cord-280624-7v8xuicg 16 11 genome genome NN cord-280624-7v8xuicg 16 12 to to TO cord-280624-7v8xuicg 16 13 identify identify VB cord-280624-7v8xuicg 16 14 any any DT cord-280624-7v8xuicg 16 15 potential potential JJ cord-280624-7v8xuicg 16 16 significant significant JJ cord-280624-7v8xuicg 16 17 mutations mutation NNS cord-280624-7v8xuicg 16 18 in in IN cord-280624-7v8xuicg 16 19 the the DT cord-280624-7v8xuicg 16 20 future future NN cord-280624-7v8xuicg 16 21 . . . cord-280624-7v8xuicg 17 1 belong belong VB cord-280624-7v8xuicg 17 2 to to IN cord-280624-7v8xuicg 17 3 the the DT cord-280624-7v8xuicg 17 4 Betacoronaviruses Betacoronaviruses NNP cord-280624-7v8xuicg 17 5 . . . cord-280624-7v8xuicg 18 1 3 3 LS cord-280624-7v8xuicg 19 1 The the DT cord-280624-7v8xuicg 19 2 SARS SARS NNP cord-280624-7v8xuicg 19 3 - - HYPH cord-280624-7v8xuicg 19 4 CoV CoV NNP cord-280624-7v8xuicg 19 5 emerged emerge VBD cord-280624-7v8xuicg 19 6 in in IN cord-280624-7v8xuicg 19 7 2003 2003 CD cord-280624-7v8xuicg 19 8 ; ; : cord-280624-7v8xuicg 19 9 the the DT cord-280624-7v8xuicg 19 10 MERS MERS NNP cord-280624-7v8xuicg 19 11 - - HYPH cord-280624-7v8xuicg 19 12 CoV CoV NNP cord-280624-7v8xuicg 19 13 was be VBD cord-280624-7v8xuicg 19 14 discovered discover VBN cord-280624-7v8xuicg 19 15 in in IN cord-280624-7v8xuicg 19 16 2012 2012 CD cord-280624-7v8xuicg 19 17 , , , cord-280624-7v8xuicg 19 18 and and CC cord-280624-7v8xuicg 19 19 the the DT cord-280624-7v8xuicg 19 20 SARS SARS NNP cord-280624-7v8xuicg 19 21 - - HYPH cord-280624-7v8xuicg 19 22 CoV-2 CoV-2 NNP cord-280624-7v8xuicg 19 23 was be VBD cord-280624-7v8xuicg 19 24 reported report VBN cord-280624-7v8xuicg 19 25 in in IN cord-280624-7v8xuicg 19 26 late late JJ cord-280624-7v8xuicg 19 27 2019 2019 CD cord-280624-7v8xuicg 19 28 . . . cord-280624-7v8xuicg 20 1 The the DT cord-280624-7v8xuicg 20 2 time time NN cord-280624-7v8xuicg 20 3 gap gap NN cord-280624-7v8xuicg 20 4 between between IN cord-280624-7v8xuicg 20 5 SARS SARS NNP cord-280624-7v8xuicg 20 6 - - HYPH cord-280624-7v8xuicg 20 7 CoV CoV NNP cord-280624-7v8xuicg 20 8 and and CC cord-280624-7v8xuicg 20 9 MERS MERS NNP cord-280624-7v8xuicg 20 10 - - HYPH cord-280624-7v8xuicg 20 11 CoV CoV NNP cord-280624-7v8xuicg 20 12 is be VBZ cord-280624-7v8xuicg 20 13 around around RB cord-280624-7v8xuicg 20 14 9 9 CD cord-280624-7v8xuicg 20 15 years year NNS cord-280624-7v8xuicg 20 16 , , , cord-280624-7v8xuicg 20 17 and and CC cord-280624-7v8xuicg 20 18 between between IN cord-280624-7v8xuicg 20 19 the the DT cord-280624-7v8xuicg 20 20 emergence emergence NN cord-280624-7v8xuicg 20 21 of of IN cord-280624-7v8xuicg 20 22 MERS MERS NNP cord-280624-7v8xuicg 20 23 - - HYPH cord-280624-7v8xuicg 20 24 CoV CoV NNP cord-280624-7v8xuicg 20 25 and and CC cord-280624-7v8xuicg 20 26 SARS SARS NNP cord-280624-7v8xuicg 20 27 - - HYPH cord-280624-7v8xuicg 20 28 CoV-2 CoV-2 NNP cord-280624-7v8xuicg 20 29 is be VBZ cord-280624-7v8xuicg 20 30 7 7 CD cord-280624-7v8xuicg 20 31 years year NNS cord-280624-7v8xuicg 20 32 . . . cord-280624-7v8xuicg 21 1 The the DT cord-280624-7v8xuicg 21 2 continuous continuous JJ cord-280624-7v8xuicg 21 3 emergence emergence NN cord-280624-7v8xuicg 21 4 of of IN cord-280624-7v8xuicg 21 5 new new JJ cord-280624-7v8xuicg 21 6 coronaviruses coronaviruse NNS cord-280624-7v8xuicg 21 7 candidates candidate NNS cord-280624-7v8xuicg 21 8 may may MD cord-280624-7v8xuicg 21 9 be be VB cord-280624-7v8xuicg 21 10 attributed attribute VBN cord-280624-7v8xuicg 21 11 to to IN cord-280624-7v8xuicg 21 12 the the DT cord-280624-7v8xuicg 21 13 features feature NNS cord-280624-7v8xuicg 21 14 of of IN cord-280624-7v8xuicg 21 15 their -PRON- PRP$ cord-280624-7v8xuicg 21 16 genomes genome NNS cord-280624-7v8xuicg 21 17 . . . cord-280624-7v8xuicg 22 1 This this DT cord-280624-7v8xuicg 22 2 may may MD cord-280624-7v8xuicg 22 3 be be VB cord-280624-7v8xuicg 22 4 due due JJ cord-280624-7v8xuicg 22 5 to to IN cord-280624-7v8xuicg 22 6 several several JJ cord-280624-7v8xuicg 22 7 factors factor NNS cord-280624-7v8xuicg 22 8 , , , cord-280624-7v8xuicg 22 9 including include VBG cord-280624-7v8xuicg 22 10 the the DT cord-280624-7v8xuicg 22 11 low low JJ cord-280624-7v8xuicg 22 12 fidelity fidelity NN cord-280624-7v8xuicg 22 13 of of IN cord-280624-7v8xuicg 22 14 their -PRON- PRP$ cord-280624-7v8xuicg 22 15 RNA RNA NNP cord-280624-7v8xuicg 22 16 - - HYPH cord-280624-7v8xuicg 22 17 dependant dependant JJ cord-280624-7v8xuicg 22 18 RNA RNA NNP cord-280624-7v8xuicg 22 19 polymerases polymerase NNS cord-280624-7v8xuicg 22 20 ( ( -LRB- cord-280624-7v8xuicg 22 21 RdRp RdRp NNP cord-280624-7v8xuicg 22 22 ) ) -RRB- cord-280624-7v8xuicg 22 23 , , , cord-280624-7v8xuicg 22 24 the the DT cord-280624-7v8xuicg 22 25 possibility possibility NN cord-280624-7v8xuicg 22 26 of of IN cord-280624-7v8xuicg 22 27 recombination recombination NN cord-280624-7v8xuicg 22 28 , , , cord-280624-7v8xuicg 22 29 and and CC cord-280624-7v8xuicg 22 30 the the DT cord-280624-7v8xuicg 22 31 high high JJ cord-280624-7v8xuicg 22 32 level level NN cord-280624-7v8xuicg 22 33 of of IN cord-280624-7v8xuicg 22 34 expression expression NN cord-280624-7v8xuicg 22 35 of of IN cord-280624-7v8xuicg 22 36 their -PRON- PRP$ cord-280624-7v8xuicg 22 37 receptors receptor NNS cord-280624-7v8xuicg 22 38 in in IN cord-280624-7v8xuicg 22 39 many many JJ cord-280624-7v8xuicg 22 40 mammalian mammalian JJ cord-280624-7v8xuicg 22 41 and and CC cord-280624-7v8xuicg 22 42 avian avian JJ cord-280624-7v8xuicg 22 43 species specie NNS cord-280624-7v8xuicg 22 44 . . . cord-280624-7v8xuicg 23 1 4 4 LS cord-280624-7v8xuicg 24 1 Thus thus RB cord-280624-7v8xuicg 24 2 , , , cord-280624-7v8xuicg 24 3 there there EX cord-280624-7v8xuicg 24 4 is be VBZ cord-280624-7v8xuicg 24 5 an an DT cord-280624-7v8xuicg 24 6 urgent urgent JJ cord-280624-7v8xuicg 24 7 need need NN cord-280624-7v8xuicg 24 8 for for IN cord-280624-7v8xuicg 24 9 the the DT cord-280624-7v8xuicg 24 10 regular regular JJ cord-280624-7v8xuicg 24 11 monitoring monitoring NN cord-280624-7v8xuicg 24 12 of of IN cord-280624-7v8xuicg 24 13 the the DT cord-280624-7v8xuicg 24 14 genome genome NN cord-280624-7v8xuicg 24 15 sequences sequence NNS cord-280624-7v8xuicg 24 16 of of IN cord-280624-7v8xuicg 24 17 coronaviruses coronaviruse NNS cord-280624-7v8xuicg 24 18 from from IN cord-280624-7v8xuicg 24 19 various various JJ cord-280624-7v8xuicg 24 20 species specie NNS cord-280624-7v8xuicg 24 21 of of IN cord-280624-7v8xuicg 24 22 bats bat NNS cord-280624-7v8xuicg 24 23 , , , cord-280624-7v8xuicg 24 24 animals animal NNS cord-280624-7v8xuicg 24 25 , , , cord-280624-7v8xuicg 24 26 and and CC cord-280624-7v8xuicg 24 27 birds bird NNS cord-280624-7v8xuicg 24 28 . . . cord-280624-7v8xuicg 25 1 [ [ -LRB- cord-280624-7v8xuicg 25 2 5 5 CD cord-280624-7v8xuicg 25 3 ] ] -RRB- cord-280624-7v8xuicg 25 4 [ [ -LRB- cord-280624-7v8xuicg 25 5 6 6 CD cord-280624-7v8xuicg 25 6 ] ] -RRB- cord-280624-7v8xuicg 25 7 [ [ -LRB- cord-280624-7v8xuicg 25 8 7 7 CD cord-280624-7v8xuicg 25 9 ] ] -RRB- cord-280624-7v8xuicg 26 1 [ [ -LRB- cord-280624-7v8xuicg 26 2 8 8 CD cord-280624-7v8xuicg 26 3 ] ] -RRB- cord-280624-7v8xuicg 26 4 [ [ -LRB- cord-280624-7v8xuicg 26 5 9 9 CD cord-280624-7v8xuicg 26 6 ] ] -RRB- cord-280624-7v8xuicg 26 7 [ [ -LRB- cord-280624-7v8xuicg 26 8 10 10 CD cord-280624-7v8xuicg 26 9 ] ] -RRB- cord-280624-7v8xuicg 27 1 [ [ -LRB- cord-280624-7v8xuicg 27 2 11 11 CD cord-280624-7v8xuicg 27 3 ] ] -RRB- cord-280624-7v8xuicg 28 1 [ [ -LRB- cord-280624-7v8xuicg 28 2 12 12 CD cord-280624-7v8xuicg 28 3 ] ] -RRB- cord-280624-7v8xuicg 29 1 The the DT cord-280624-7v8xuicg 29 2 main main JJ cord-280624-7v8xuicg 29 3 goal goal NN cord-280624-7v8xuicg 29 4 of of IN cord-280624-7v8xuicg 29 5 the the DT cord-280624-7v8xuicg 29 6 current current JJ cord-280624-7v8xuicg 29 7 study study NN cord-280624-7v8xuicg 29 8 was be VBD cord-280624-7v8xuicg 29 9 to to TO cord-280624-7v8xuicg 29 10 do do VB cord-280624-7v8xuicg 29 11 a a DT cord-280624-7v8xuicg 29 12 com- com- NN cord-280624-7v8xuicg 29 13 includes include VBZ cord-280624-7v8xuicg 29 14 the the DT cord-280624-7v8xuicg 29 15 majority majority NN cord-280624-7v8xuicg 29 16 of of IN cord-280624-7v8xuicg 29 17 viral viral JJ cord-280624-7v8xuicg 29 18 isolates isolate NNS cord-280624-7v8xuicg 29 19 from from IN cord-280624-7v8xuicg 29 20 human human JJ cord-280624-7v8xuicg 29 21 and and CC cord-280624-7v8xuicg 29 22 some some DT cord-280624-7v8xuicg 29 23 from from IN cord-280624-7v8xuicg 29 24 camel camel NN cord-280624-7v8xuicg 29 25 origins origin NNS cord-280624-7v8xuicg 29 26 . . . cord-280624-7v8xuicg 30 1 14 14 CD cord-280624-7v8xuicg 30 2 Clade Clade NNP cord-280624-7v8xuicg 30 3 - - HYPH cord-280624-7v8xuicg 30 4 C C NNP cord-280624-7v8xuicg 30 5 includes include VBZ cord-280624-7v8xuicg 30 6 viruses virus NNS cord-280624-7v8xuicg 30 7 of of IN cord-280624-7v8xuicg 30 8 camel camel NN cord-280624-7v8xuicg 30 9 origin origin NN cord-280624-7v8xuicg 30 10 isolated isolate VBN cord-280624-7v8xuicg 30 11 from from IN cord-280624-7v8xuicg 30 12 various various JJ cord-280624-7v8xuicg 30 13 countries country NNS cord-280624-7v8xuicg 30 14 in in IN cord-280624-7v8xuicg 30 15 Africa Africa NNP cord-280624-7v8xuicg 30 16 , , , cord-280624-7v8xuicg 30 17 including include VBG cord-280624-7v8xuicg 30 18 Egypt Egypt NNP cord-280624-7v8xuicg 30 19 , , , cord-280624-7v8xuicg 30 20 Morocco Morocco NNP cord-280624-7v8xuicg 30 21 , , , cord-280624-7v8xuicg 30 22 Nigeria Nigeria NNP cord-280624-7v8xuicg 30 23 , , , cord-280624-7v8xuicg 30 24 Burkina Burkina NNP cord-280624-7v8xuicg 30 25 Faso Faso NNP cord-280624-7v8xuicg 30 26 , , , cord-280624-7v8xuicg 30 27 and and CC cord-280624-7v8xuicg 30 28 Kenya Kenya NNP cord-280624-7v8xuicg 30 29 . . . cord-280624-7v8xuicg 31 1 13 13 CD cord-280624-7v8xuicg 31 2 , , , cord-280624-7v8xuicg 31 3 15 15 CD cord-280624-7v8xuicg 31 4 Interestingly interestingly RB cord-280624-7v8xuicg 31 5 , , , cord-280624-7v8xuicg 31 6 results result VBZ cord-280624-7v8xuicg 31 7 from from IN cord-280624-7v8xuicg 31 8 the the DT cord-280624-7v8xuicg 31 9 virus virus NN cord-280624-7v8xuicg 31 10 neutralization neutralization NN cord-280624-7v8xuicg 31 11 assay assay NN cord-280624-7v8xuicg 31 12 revealed reveal VBD cord-280624-7v8xuicg 31 13 that that IN cord-280624-7v8xuicg 31 14 all all DT cord-280624-7v8xuicg 31 15 three three CD cord-280624-7v8xuicg 31 16 clades clade NNS cord-280624-7v8xuicg 31 17 are be VBP cord-280624-7v8xuicg 31 18 closely closely RB cord-280624-7v8xuicg 31 19 related relate VBN cord-280624-7v8xuicg 31 20 , , , cord-280624-7v8xuicg 31 21 which which WDT cord-280624-7v8xuicg 31 22 supports support VBZ cord-280624-7v8xuicg 31 23 the the DT cord-280624-7v8xuicg 31 24 notion notion NN cord-280624-7v8xuicg 31 25 that that IN cord-280624-7v8xuicg 31 26 one one CD cord-280624-7v8xuicg 31 27 vaccine vaccine NN cord-280624-7v8xuicg 31 28 may may MD cord-280624-7v8xuicg 31 29 be be VB cord-280624-7v8xuicg 31 30 able able JJ cord-280624-7v8xuicg 31 31 to to TO cord-280624-7v8xuicg 31 32 protect protect VB cord-280624-7v8xuicg 31 33 against against IN cord-280624-7v8xuicg 31 34 all all DT cord-280624-7v8xuicg 31 35 three three CD cord-280624-7v8xuicg 31 36 clades clade NNS cord-280624-7v8xuicg 31 37 . . . cord-280624-7v8xuicg 32 1 13 13 CD cord-280624-7v8xuicg 33 1 It -PRON- PRP cord-280624-7v8xuicg 33 2 is be VBZ cord-280624-7v8xuicg 33 3 believed believe VBN cord-280624-7v8xuicg 33 4 that that IN cord-280624-7v8xuicg 33 5 MERS MERS NNP cord-280624-7v8xuicg 33 6 - - HYPH cord-280624-7v8xuicg 33 7 CoV CoV NNP cord-280624-7v8xuicg 33 8 originated originate VBD cord-280624-7v8xuicg 33 9 in in IN cord-280624-7v8xuicg 33 10 bats bat NNS cord-280624-7v8xuicg 33 11 and and CC cord-280624-7v8xuicg 33 12 spilled spill VBD cord-280624-7v8xuicg 33 13 over over RP cord-280624-7v8xuicg 33 14 to to IN cord-280624-7v8xuicg 33 15 humans human NNS cord-280624-7v8xuicg 33 16 via via IN cord-280624-7v8xuicg 33 17 an an DT cord-280624-7v8xuicg 33 18 intermediate intermediate JJ cord-280624-7v8xuicg 33 19 host host NN cord-280624-7v8xuicg 33 20 , , , cord-280624-7v8xuicg 33 21 dromedary dromedary NN cord-280624-7v8xuicg 33 22 camels camel NNS cord-280624-7v8xuicg 33 23 . . . cord-280624-7v8xuicg 34 1 16 16 CD cord-280624-7v8xuicg 34 2 , , , cord-280624-7v8xuicg 34 3 17 17 CD cord-280624-7v8xuicg 34 4 Dromedary Dromedary NNP cord-280624-7v8xuicg 34 5 camels camel NNS cord-280624-7v8xuicg 34 6 are be VBP cord-280624-7v8xuicg 34 7 the the DT cord-280624-7v8xuicg 34 8 main main JJ cord-280624-7v8xuicg 34 9 known know VBN cord-280624-7v8xuicg 34 10 reservoir reservoir NN cord-280624-7v8xuicg 34 11 until until IN cord-280624-7v8xuicg 34 12 now now RB cord-280624-7v8xuicg 34 13 . . . cord-280624-7v8xuicg 35 1 18 18 CD cord-280624-7v8xuicg 35 2 Genome Genome NNP cord-280624-7v8xuicg 35 3 analysis analysis NN cord-280624-7v8xuicg 35 4 of of IN cord-280624-7v8xuicg 35 5 MERS MERS NNP cord-280624-7v8xuicg 35 6 - - HYPH cord-280624-7v8xuicg 35 7 CoV CoV NNP cord-280624-7v8xuicg 35 8 isolates isolate NNS cord-280624-7v8xuicg 35 9 from from IN cord-280624-7v8xuicg 35 10 human human JJ cord-280624-7v8xuicg 35 11 and and CC cord-280624-7v8xuicg 35 12 dromedary dromedary NN cord-280624-7v8xuicg 35 13 camel camel NN cord-280624-7v8xuicg 35 14 origins origin NNS cord-280624-7v8xuicg 35 15 revealed reveal VBD cord-280624-7v8xuicg 35 16 a a DT cord-280624-7v8xuicg 35 17 close close JJ cord-280624-7v8xuicg 35 18 relationship relationship NN cord-280624-7v8xuicg 35 19 between between IN cord-280624-7v8xuicg 35 20 each each DT cord-280624-7v8xuicg 35 21 other other JJ cord-280624-7v8xuicg 35 22 , , , cord-280624-7v8xuicg 35 23 suggesting suggest VBG cord-280624-7v8xuicg 35 24 the the DT cord-280624-7v8xuicg 35 25 zoonotic zoonotic JJ cord-280624-7v8xuicg 35 26 origin origin NN cord-280624-7v8xuicg 35 27 of of IN cord-280624-7v8xuicg 35 28 the the DT cord-280624-7v8xuicg 35 29 virus virus NN cord-280624-7v8xuicg 35 30 . . . cord-280624-7v8xuicg 36 1 14 14 CD cord-280624-7v8xuicg 37 1 Like like IN cord-280624-7v8xuicg 37 2 other other JJ cord-280624-7v8xuicg 37 3 coronaviruses coronaviruse NNS cord-280624-7v8xuicg 37 4 , , , cord-280624-7v8xuicg 37 5 MERS MERS NNP cord-280624-7v8xuicg 37 6 - - HYPH cord-280624-7v8xuicg 37 7 CoV CoV NNP cord-280624-7v8xuicg 37 8 continues continue VBZ cord-280624-7v8xuicg 37 9 to to TO cord-280624-7v8xuicg 37 10 show show VB cord-280624-7v8xuicg 37 11 some some DT cord-280624-7v8xuicg 37 12 changes change NNS cord-280624-7v8xuicg 37 13 at at IN cord-280624-7v8xuicg 37 14 the the DT cord-280624-7v8xuicg 37 15 genome genome NN cord-280624-7v8xuicg 37 16 level level NN cord-280624-7v8xuicg 37 17 . . . cord-280624-7v8xuicg 38 1 Thus thus RB cord-280624-7v8xuicg 38 2 , , , cord-280624-7v8xuicg 38 3 new new JJ cord-280624-7v8xuicg 38 4 virus virus NN cord-280624-7v8xuicg 38 5 clades clade NNS cord-280624-7v8xuicg 38 6 and and CC cord-280624-7v8xuicg 38 7 sub sub NN cord-280624-7v8xuicg 38 8 - - NNS cord-280624-7v8xuicg 38 9 clades clade NNS cord-280624-7v8xuicg 38 10 are be VBP cord-280624-7v8xuicg 38 11 recently recently RB cord-280624-7v8xuicg 38 12 reported report VBN cord-280624-7v8xuicg 38 13 of of IN cord-280624-7v8xuicg 38 14 both both DT cord-280624-7v8xuicg 38 15 human human JJ cord-280624-7v8xuicg 38 16 and and CC cord-280624-7v8xuicg 38 17 dromedary dromedary NN cord-280624-7v8xuicg 38 18 camel camel NN cord-280624-7v8xuicg 38 19 origins origin NNS cord-280624-7v8xuicg 38 20 . . . cord-280624-7v8xuicg 39 1 19 19 CD cord-280624-7v8xuicg 39 2 Regular regular JJ cord-280624-7v8xuicg 39 3 monitoring monitoring NN cord-280624-7v8xuicg 39 4 of of IN cord-280624-7v8xuicg 39 5 the the DT cord-280624-7v8xuicg 39 6 genetic genetic JJ cord-280624-7v8xuicg 39 7 makeup makeup NN cord-280624-7v8xuicg 39 8 of of IN cord-280624-7v8xuicg 39 9 the the DT cord-280624-7v8xuicg 39 10 virus virus NN cord-280624-7v8xuicg 39 11 is be VBZ cord-280624-7v8xuicg 39 12 very very RB cord-280624-7v8xuicg 39 13 important important JJ cord-280624-7v8xuicg 39 14 to to TO cord-280624-7v8xuicg 39 15 track track VB cord-280624-7v8xuicg 39 16 down down RP cord-280624-7v8xuicg 39 17 any any DT cord-280624-7v8xuicg 39 18 potential potential JJ cord-280624-7v8xuicg 39 19 mutation mutation NN cord-280624-7v8xuicg 39 20 or or CC cord-280624-7v8xuicg 39 21 recombination recombination NN cord-280624-7v8xuicg 39 22 . . . cord-280624-7v8xuicg 40 1 The the DT cord-280624-7v8xuicg 40 2 main main JJ cord-280624-7v8xuicg 40 3 goal goal NN cord-280624-7v8xuicg 40 4 of of IN cord-280624-7v8xuicg 40 5 this this DT cord-280624-7v8xuicg 40 6 study study NN cord-280624-7v8xuicg 40 7 was be VBD cord-280624-7v8xuicg 40 8 to to TO cord-280624-7v8xuicg 40 9 do do VB cord-280624-7v8xuicg 40 10 a a DT cord-280624-7v8xuicg 40 11 deep deep JJ cord-280624-7v8xuicg 40 12 bioinformatic bioinformatic JJ cord-280624-7v8xuicg 40 13 analysis analysis NN cord-280624-7v8xuicg 40 14 of of IN cord-280624-7v8xuicg 40 15 the the DT cord-280624-7v8xuicg 40 16 most most RBS cord-280624-7v8xuicg 40 17 available available JJ cord-280624-7v8xuicg 40 18 MERs MERs NNPS cord-280624-7v8xuicg 40 19 - - HYPH cord-280624-7v8xuicg 40 20 CoV cov NN cord-280624-7v8xuicg 40 21 genome genome NN cord-280624-7v8xuicg 40 22 sequences sequence NNS cord-280624-7v8xuicg 40 23 in in IN cord-280624-7v8xuicg 40 24 Genbank Genbank NNP cord-280624-7v8xuicg 40 25 during during IN cord-280624-7v8xuicg 40 26 2012 2012 CD cord-280624-7v8xuicg 40 27 to to IN cord-280624-7v8xuicg 40 28 2019 2019 CD cord-280624-7v8xuicg 40 29 to to TO cord-280624-7v8xuicg 40 30 understand understand VB cord-280624-7v8xuicg 40 31 the the DT cord-280624-7v8xuicg 40 32 evolution evolution NN cord-280624-7v8xuicg 40 33 of of IN cord-280624-7v8xuicg 40 34 the the DT cord-280624-7v8xuicg 40 35 virus virus NN cord-280624-7v8xuicg 40 36 and and CC cord-280624-7v8xuicg 40 37 map map VB cord-280624-7v8xuicg 40 38 any any DT cord-280624-7v8xuicg 40 39 potential potential JJ cord-280624-7v8xuicg 40 40 changes change NNS cord-280624-7v8xuicg 40 41 across across IN cord-280624-7v8xuicg 40 42 the the DT cord-280624-7v8xuicg 40 43 viral viral JJ cord-280624-7v8xuicg 40 44 genome genome NN cord-280624-7v8xuicg 40 45 . . . cord-280624-7v8xuicg 41 1 Therefore therefore RB cord-280624-7v8xuicg 41 2 , , , cord-280624-7v8xuicg 41 3 the the DT cord-280624-7v8xuicg 41 4 development development NN cord-280624-7v8xuicg 41 5 of of IN cord-280624-7v8xuicg 41 6 potential potential JJ cord-280624-7v8xuicg 41 7 diagnostic diagnostic JJ cord-280624-7v8xuicg 41 8 assays assay NNS cord-280624-7v8xuicg 41 9 , , , cord-280624-7v8xuicg 41 10 vaccines vaccine NNS cord-280624-7v8xuicg 41 11 , , , cord-280624-7v8xuicg 41 12 or or CC cord-280624-7v8xuicg 41 13 therapy therapy NN cord-280624-7v8xuicg 41 14 should should MD cord-280624-7v8xuicg 41 15 cope cope VB cord-280624-7v8xuicg 41 16 with with IN cord-280624-7v8xuicg 41 17 any any DT cord-280624-7v8xuicg 41 18 potential potential JJ cord-280624-7v8xuicg 41 19 changes change NNS cord-280624-7v8xuicg 41 20 over over IN cord-280624-7v8xuicg 41 21 the the DT cord-280624-7v8xuicg 41 22 viral viral JJ cord-280624-7v8xuicg 41 23 genome genome NN cord-280624-7v8xuicg 41 24 . . . cord-280624-7v8xuicg 42 1 This this DT cord-280624-7v8xuicg 42 2 monitoring monitoring NN cord-280624-7v8xuicg 42 3 may may MD cord-280624-7v8xuicg 42 4 also also RB cord-280624-7v8xuicg 42 5 contribute contribute VB cord-280624-7v8xuicg 42 6 substantially substantially RB cord-280624-7v8xuicg 42 7 to to IN cord-280624-7v8xuicg 42 8 the the DT cord-280624-7v8xuicg 42 9 control control NN cord-280624-7v8xuicg 42 10 of of IN cord-280624-7v8xuicg 42 11 the the DT cord-280624-7v8xuicg 42 12 virus virus NN cord-280624-7v8xuicg 42 13 by by IN cord-280624-7v8xuicg 42 14 knowing know VBG cord-280624-7v8xuicg 42 15 the the DT cord-280624-7v8xuicg 42 16 currently currently RB cord-280624-7v8xuicg 42 17 circulating circulate VBG cord-280624-7v8xuicg 42 18 clades clade NNS cord-280624-7v8xuicg 42 19 in in IN cord-280624-7v8xuicg 42 20 a a DT cord-280624-7v8xuicg 42 21 certain certain JJ cord-280624-7v8xuicg 42 22 community community NN cord-280624-7v8xuicg 42 23 . . . cord-280624-7v8xuicg 43 1 An an DT cord-280624-7v8xuicg 43 2 earlier early JJR cord-280624-7v8xuicg 43 3 study study NN cord-280624-7v8xuicg 43 4 showed show VBD cord-280624-7v8xuicg 43 5 the the DT cord-280624-7v8xuicg 43 6 circulation circulation NN cord-280624-7v8xuicg 43 7 of of IN cord-280624-7v8xuicg 43 8 three three CD cord-280624-7v8xuicg 43 9 different different JJ cord-280624-7v8xuicg 43 10 genotypes genotype NNS cord-280624-7v8xuicg 43 11 of of IN cord-280624-7v8xuicg 43 12 the the DT cord-280624-7v8xuicg 43 13 virus virus NN cord-280624-7v8xuicg 43 14 in in IN cord-280624-7v8xuicg 43 15 some some DT cord-280624-7v8xuicg 43 16 patients patient NNS cord-280624-7v8xuicg 43 17 during during IN cord-280624-7v8xuicg 43 18 2013 2013 CD cord-280624-7v8xuicg 43 19 in in IN cord-280624-7v8xuicg 43 20 KSA KSA NNP cord-280624-7v8xuicg 43 21 . . . cord-280624-7v8xuicg 44 1 20 20 CD cord-280624-7v8xuicg 44 2 One one CD cord-280624-7v8xuicg 44 3 year year NN cord-280624-7v8xuicg 44 4 later later RB cord-280624-7v8xuicg 44 5 , , , cord-280624-7v8xuicg 44 6 the the DT cord-280624-7v8xuicg 44 7 same same JJ cord-280624-7v8xuicg 44 8 group group NN cord-280624-7v8xuicg 44 9 reported report VBD cord-280624-7v8xuicg 44 10 the the DT cord-280624-7v8xuicg 44 11 presence presence NN cord-280624-7v8xuicg 44 12 of of IN cord-280624-7v8xuicg 44 13 four four CD cord-280624-7v8xuicg 44 14 MERS MERS NNP cord-280624-7v8xuicg 44 15 - - HYPH cord-280624-7v8xuicg 44 16 CoV cov NN cord-280624-7v8xuicg 44 17 clades clade NNS cord-280624-7v8xuicg 44 18 during during IN cord-280624-7v8xuicg 44 19 the the DT cord-280624-7v8xuicg 44 20 early early JJ cord-280624-7v8xuicg 44 21 emergence emergence NN cord-280624-7v8xuicg 44 22 of of IN cord-280624-7v8xuicg 44 23 MERS MERS NNP cord-280624-7v8xuicg 45 1 -CoV. -cov. ADD cord-280624-7v8xuicg 46 1 Later later RB cord-280624-7v8xuicg 46 2 , , , cord-280624-7v8xuicg 46 3 during during IN cord-280624-7v8xuicg 46 4 2014 2014 CD cord-280624-7v8xuicg 46 5 three three CD cord-280624-7v8xuicg 46 6 clades clade NNS cord-280624-7v8xuicg 46 7 were be VBD cord-280624-7v8xuicg 46 8 no no RB cord-280624-7v8xuicg 46 9 longer long RBR cord-280624-7v8xuicg 46 10 contributing contribute VBG cord-280624-7v8xuicg 46 11 to to IN cord-280624-7v8xuicg 46 12 the the DT cord-280624-7v8xuicg 46 13 reported report VBN cord-280624-7v8xuicg 46 14 human human JJ cord-280624-7v8xuicg 46 15 cases case NNS cord-280624-7v8xuicg 46 16 suggesting suggest VBG cord-280624-7v8xuicg 46 17 their -PRON- PRP$ cord-280624-7v8xuicg 46 18 extinction extinction NN cord-280624-7v8xuicg 46 19 . . . cord-280624-7v8xuicg 47 1 19 19 CD cord-280624-7v8xuicg 48 1 The the DT cord-280624-7v8xuicg 48 2 main main JJ cord-280624-7v8xuicg 48 3 reason reason NN cord-280624-7v8xuicg 48 4 behind behind IN cord-280624-7v8xuicg 48 5 these these DT cord-280624-7v8xuicg 48 6 changes change NNS cord-280624-7v8xuicg 48 7 was be VBD cord-280624-7v8xuicg 48 8 the the DT cord-280624-7v8xuicg 48 9 dynamic dynamic JJ cord-280624-7v8xuicg 48 10 changes change NNS cord-280624-7v8xuicg 48 11 among among IN cord-280624-7v8xuicg 48 12 the the DT cord-280624-7v8xuicg 48 13 S S NNP cord-280624-7v8xuicg 48 14 gene gene NN cord-280624-7v8xuicg 48 15 of of IN cord-280624-7v8xuicg 48 16 the the DT cord-280624-7v8xuicg 48 17 virus virus NN cord-280624-7v8xuicg 48 18 . . . cord-280624-7v8xuicg 49 1 19 19 CD cord-280624-7v8xuicg 49 2 , , , cord-280624-7v8xuicg 49 3 20 20 CD cord-280624-7v8xuicg 49 4 Studies study NNS cord-280624-7v8xuicg 49 5 on on IN cord-280624-7v8xuicg 49 6 MERS MERS NNP cord-280624-7v8xuicg 49 7 - - HYPH cord-280624-7v8xuicg 49 8 CoV CoV NNP cord-280624-7v8xuicg 49 9 isolates isolate NNS cord-280624-7v8xuicg 49 10 from from IN cord-280624-7v8xuicg 49 11 various various JJ cord-280624-7v8xuicg 49 12 countries country NNS cord-280624-7v8xuicg 49 13 in in IN cord-280624-7v8xuicg 49 14 northern northern JJ cord-280624-7v8xuicg 49 15 and and CC cord-280624-7v8xuicg 49 16 central central JJ cord-280624-7v8xuicg 49 17 Africa Africa NNP cord-280624-7v8xuicg 49 18 revealed reveal VBD cord-280624-7v8xuicg 49 19 that that IN cord-280624-7v8xuicg 49 20 the the DT cord-280624-7v8xuicg 49 21 circulating circulate VBG cord-280624-7v8xuicg 49 22 strains strain NNS cord-280624-7v8xuicg 49 23 of of IN cord-280624-7v8xuicg 49 24 the the DT cord-280624-7v8xuicg 49 25 virus virus NN cord-280624-7v8xuicg 49 26 in in IN cord-280624-7v8xuicg 49 27 dromedary dromedary NN cord-280624-7v8xuicg 49 28 camels camel NNS cord-280624-7v8xuicg 49 29 from from IN cord-280624-7v8xuicg 49 30 these these DT cord-280624-7v8xuicg 49 31 countries country NNS cord-280624-7v8xuicg 49 32 belong belong VBP cord-280624-7v8xuicg 49 33 to to IN cord-280624-7v8xuicg 49 34 lineage lineage NN cord-280624-7v8xuicg 49 35 - - HYPH cord-280624-7v8xuicg 49 36 C. c. NN cord-280624-7v8xuicg 50 1 This this DT cord-280624-7v8xuicg 50 2 lineage lineage NN cord-280624-7v8xuicg 50 3 is be VBZ cord-280624-7v8xuicg 50 4 different different JJ cord-280624-7v8xuicg 50 5 from from IN cord-280624-7v8xuicg 50 6 the the DT cord-280624-7v8xuicg 50 7 other other JJ cord-280624-7v8xuicg 50 8 two two CD cord-280624-7v8xuicg 50 9 lineages lineage NNS cord-280624-7v8xuicg 50 10 reported report VBN cord-280624-7v8xuicg 50 11 earlier early RBR cord-280624-7v8xuicg 50 12 in in IN cord-280624-7v8xuicg 50 13 the the DT cord-280624-7v8xuicg 50 14 Arabian Arabian NNP cord-280624-7v8xuicg 50 15 Peninsula Peninsula NNP cord-280624-7v8xuicg 50 16 . . . cord-280624-7v8xuicg 51 1 13 13 CD cord-280624-7v8xuicg 52 1 Although although IN cord-280624-7v8xuicg 52 2 the the DT cord-280624-7v8xuicg 52 3 three three CD cord-280624-7v8xuicg 52 4 lineages lineage NNS cord-280624-7v8xuicg 52 5 have have VBP cord-280624-7v8xuicg 52 6 some some DT cord-280624-7v8xuicg 52 7 genetic genetic JJ cord-280624-7v8xuicg 52 8 variations variation NNS cord-280624-7v8xuicg 52 9 , , , cord-280624-7v8xuicg 52 10 their -PRON- PRP$ cord-280624-7v8xuicg 52 11 antigenic antigenic JJ cord-280624-7v8xuicg 52 12 properties property NNS cord-280624-7v8xuicg 52 13 remain remain VBP cord-280624-7v8xuicg 52 14 identical identical JJ cord-280624-7v8xuicg 52 15 , , , cord-280624-7v8xuicg 52 16 as as IN cord-280624-7v8xuicg 52 17 shown show VBN cord-280624-7v8xuicg 52 18 by by IN cord-280624-7v8xuicg 52 19 the the DT cord-280624-7v8xuicg 52 20 virus virus NN cord-280624-7v8xuicg 52 21 neutralization neutralization NN cord-280624-7v8xuicg 52 22 test test NN cord-280624-7v8xuicg 52 23 . . . cord-280624-7v8xuicg 53 1 13 13 CD cord-280624-7v8xuicg 53 2 Isolates isolate NNS cord-280624-7v8xuicg 53 3 from from IN cord-280624-7v8xuicg 53 4 dromedary dromedary NN cord-280624-7v8xuicg 53 5 camels camel NNS cord-280624-7v8xuicg 53 6 collected collect VBN cord-280624-7v8xuicg 53 7 from from IN cord-280624-7v8xuicg 53 8 Nigeria Nigeria NNP cord-280624-7v8xuicg 53 9 , , , cord-280624-7v8xuicg 53 10 Burkina Burkina NNP cord-280624-7v8xuicg 53 11 Faso Faso NNP cord-280624-7v8xuicg 53 12 , , , cord-280624-7v8xuicg 53 13 and and CC cord-280624-7v8xuicg 53 14 Morocco Morocco NNP cord-280624-7v8xuicg 53 15 clustered cluster VBD cord-280624-7v8xuicg 53 16 together together RB cord-280624-7v8xuicg 53 17 into into IN cord-280624-7v8xuicg 53 18 a a DT cord-280624-7v8xuicg 53 19 new new JJ cord-280624-7v8xuicg 53 20 sublineage sublineage NN cord-280624-7v8xuicg 53 21 - - HYPH cord-280624-7v8xuicg 53 22 C1 C1 NNP cord-280624-7v8xuicg 53 23 due due IN cord-280624-7v8xuicg 53 24 to to IN cord-280624-7v8xuicg 53 25 shared share VBN cord-280624-7v8xuicg 53 26 genetic genetic JJ cord-280624-7v8xuicg 53 27 signatures signature NNS cord-280624-7v8xuicg 53 28 , , , cord-280624-7v8xuicg 53 29 including include VBG cord-280624-7v8xuicg 53 30 deletions deletion NNS cord-280624-7v8xuicg 53 31 in in IN cord-280624-7v8xuicg 53 32 ORF4b orf4b NN cord-280624-7v8xuicg 53 33 . . . cord-280624-7v8xuicg 53 34 13 13 CD cord-280624-7v8xuicg 54 1 Thus thus RB cord-280624-7v8xuicg 54 2 , , , cord-280624-7v8xuicg 54 3 there there EX cord-280624-7v8xuicg 54 4 is be VBZ cord-280624-7v8xuicg 54 5 an an DT cord-280624-7v8xuicg 54 6 urgent urgent JJ cord-280624-7v8xuicg 54 7 need need NN cord-280624-7v8xuicg 54 8 for for IN cord-280624-7v8xuicg 54 9 continued continued JJ cord-280624-7v8xuicg 54 10 study study NN cord-280624-7v8xuicg 54 11 not not RB cord-280624-7v8xuicg 54 12 only only RB cord-280624-7v8xuicg 54 13 of of IN cord-280624-7v8xuicg 54 14 MERS MERS NNP cord-280624-7v8xuicg 54 15 - - HYPH cord-280624-7v8xuicg 54 16 CoV CoV NNP cord-280624-7v8xuicg 54 17 but but CC cord-280624-7v8xuicg 54 18 also also RB cord-280624-7v8xuicg 54 19 other other JJ cord-280624-7v8xuicg 54 20 coronaviruses coronaviruse NNS cord-280624-7v8xuicg 54 21 in in IN cord-280624-7v8xuicg 54 22 the the DT cord-280624-7v8xuicg 54 23 context context NN cord-280624-7v8xuicg 54 24 of of IN cord-280624-7v8xuicg 54 25 the the DT cord-280624-7v8xuicg 54 26 human human JJ cord-280624-7v8xuicg 54 27 - - HYPH cord-280624-7v8xuicg 54 28 animal animal NN cord-280624-7v8xuicg 54 29 interface interface NN cord-280624-7v8xuicg 54 30 and and CC cord-280624-7v8xuicg 54 31 to to TO cord-280624-7v8xuicg 54 32 understand understand VB cord-280624-7v8xuicg 54 33 the the DT cord-280624-7v8xuicg 54 34 biological biological JJ cord-280624-7v8xuicg 54 35 diversity diversity NN cord-280624-7v8xuicg 54 36 of of IN cord-280624-7v8xuicg 54 37 coronaviruses coronaviruse NNS cord-280624-7v8xuicg 54 38 . . . cord-280624-7v8xuicg 54 39 _SP cord-280624-7v8xuicg 55 1 MERS MERS NNP cord-280624-7v8xuicg 55 2 - - HYPH cord-280624-7v8xuicg 55 3 CoV CoV NNP cord-280624-7v8xuicg 55 4 submissions submission NNS cord-280624-7v8xuicg 55 5 were be VBD cord-280624-7v8xuicg 55 6 considered consider VBN cord-280624-7v8xuicg 55 7 as as IN cord-280624-7v8xuicg 55 8 a a DT cord-280624-7v8xuicg 55 9 full full JJ cord-280624-7v8xuicg 55 10 - - HYPH cord-280624-7v8xuicg 55 11 length length NN cord-280624-7v8xuicg 55 12 genome genome NN cord-280624-7v8xuicg 55 13 only only RB cord-280624-7v8xuicg 55 14 if if IN cord-280624-7v8xuicg 55 15 they -PRON- PRP cord-280624-7v8xuicg 55 16 meet meet VBP cord-280624-7v8xuicg 55 17 three three CD cord-280624-7v8xuicg 55 18 parameters parameter NNS cord-280624-7v8xuicg 55 19 . . . cord-280624-7v8xuicg 56 1 First first RB cord-280624-7v8xuicg 56 2 , , , cord-280624-7v8xuicg 56 3 the the DT cord-280624-7v8xuicg 56 4 length length NN cord-280624-7v8xuicg 56 5 of of IN cord-280624-7v8xuicg 56 6 the the DT cord-280624-7v8xuicg 56 7 sequence sequence NN cord-280624-7v8xuicg 56 8 must must MD cord-280624-7v8xuicg 56 9 be be VB cord-280624-7v8xuicg 56 10 greater great JJR cord-280624-7v8xuicg 56 11 than than IN cord-280624-7v8xuicg 56 12 or or CC cord-280624-7v8xuicg 56 13 equal equal JJ cord-280624-7v8xuicg 56 14 to to IN cord-280624-7v8xuicg 56 15 30-kilobases 30-kilobases CD cord-280624-7v8xuicg 56 16 . . . cord-280624-7v8xuicg 57 1 Second second RB cord-280624-7v8xuicg 57 2 , , , cord-280624-7v8xuicg 57 3 the the DT cord-280624-7v8xuicg 57 4 submission submission NN cord-280624-7v8xuicg 57 5 must must MD cord-280624-7v8xuicg 57 6 have have VB cord-280624-7v8xuicg 57 7 the the DT cord-280624-7v8xuicg 57 8 full full JJ cord-280624-7v8xuicg 57 9 5 5 CD cord-280624-7v8xuicg 57 10 0 0 CD cord-280624-7v8xuicg 57 11 UTR UTR NNP cord-280624-7v8xuicg 57 12 sequence sequence NN cord-280624-7v8xuicg 57 13 . . . cord-280624-7v8xuicg 58 1 Third third RB cord-280624-7v8xuicg 58 2 , , , cord-280624-7v8xuicg 58 3 the the DT cord-280624-7v8xuicg 58 4 submission submission NN cord-280624-7v8xuicg 58 5 must must MD cord-280624-7v8xuicg 58 6 have have VB cord-280624-7v8xuicg 58 7 a a DT cord-280624-7v8xuicg 58 8 poly poly JJ cord-280624-7v8xuicg 58 9 - - HYPH cord-280624-7v8xuicg 58 10 A a DT cord-280624-7v8xuicg 58 11 tail tail NN cord-280624-7v8xuicg 58 12 even even RB cord-280624-7v8xuicg 58 13 represented represent VBN cord-280624-7v8xuicg 58 14 by by IN cord-280624-7v8xuicg 58 15 one one CD cord-280624-7v8xuicg 58 16 nucleotide nucleotide NN cord-280624-7v8xuicg 58 17 of of IN cord-280624-7v8xuicg 58 18 adenine adenine NN cord-280624-7v8xuicg 58 19 ( ( -LRB- cord-280624-7v8xuicg 58 20 A a NN cord-280624-7v8xuicg 58 21 ) ) -RRB- cord-280624-7v8xuicg 58 22 . . . cord-280624-7v8xuicg 59 1 Multiple multiple JJ cord-280624-7v8xuicg 59 2 sequence sequence NN cord-280624-7v8xuicg 59 3 alignment alignment NN cord-280624-7v8xuicg 59 4 was be VBD cord-280624-7v8xuicg 59 5 conducted conduct VBN cord-280624-7v8xuicg 59 6 using use VBG cord-280624-7v8xuicg 59 7 the the DT cord-280624-7v8xuicg 59 8 MAFFT MAFFT NNP cord-280624-7v8xuicg 59 9 tool tool NN cord-280624-7v8xuicg 59 10 ( ( -LRB- cord-280624-7v8xuicg 59 11 http://ma.cbrc.jp/alignment/soware/ http://ma.cbrc.jp/alignment/soware/ NN cord-280624-7v8xuicg 59 12 ) ) -RRB- cord-280624-7v8xuicg 59 13 . . . cord-280624-7v8xuicg 60 1 Single single JJ cord-280624-7v8xuicg 60 2 nucleotide nucleotide JJ cord-280624-7v8xuicg 60 3 polymorphism polymorphism NN cord-280624-7v8xuicg 60 4 ( ( -LRB- cord-280624-7v8xuicg 60 5 SNP SNP NNP cord-280624-7v8xuicg 60 6 ) ) -RRB- cord-280624-7v8xuicg 60 7 density density NN cord-280624-7v8xuicg 60 8 ( ( -LRB- cord-280624-7v8xuicg 60 9 excluding exclude VBG cord-280624-7v8xuicg 60 10 indels indel NNS cord-280624-7v8xuicg 60 11 ) ) -RRB- cord-280624-7v8xuicg 60 12 was be VBD cord-280624-7v8xuicg 60 13 counted count VBN cord-280624-7v8xuicg 60 14 from from IN cord-280624-7v8xuicg 60 15 the the DT cord-280624-7v8xuicg 60 16 multiplesequence multiplesequence NNP cord-280624-7v8xuicg 60 17 alignment alignment NN cord-280624-7v8xuicg 60 18 of of IN cord-280624-7v8xuicg 60 19 544 544 CD cord-280624-7v8xuicg 60 20 ORF1ab ORF1ab NNP cord-280624-7v8xuicg 60 21 and and CC cord-280624-7v8xuicg 60 22 744 744 NNP cord-280624-7v8xuicg 60 23 S s NN cord-280624-7v8xuicg 60 24 gene gene NN cord-280624-7v8xuicg 60 25 sequences sequence NNS cord-280624-7v8xuicg 60 26 by by IN cord-280624-7v8xuicg 60 27 use use NN cord-280624-7v8xuicg 60 28 of of IN cord-280624-7v8xuicg 60 29 an an DT cord-280624-7v8xuicg 60 30 in in IN cord-280624-7v8xuicg 60 31 - - HYPH cord-280624-7v8xuicg 60 32 house house NN cord-280624-7v8xuicg 60 33 script script NN cord-280624-7v8xuicg 60 34 written write VBN cord-280624-7v8xuicg 60 35 in in IN cord-280624-7v8xuicg 60 36 python python NNP cord-280624-7v8xuicg 60 37 . . . cord-280624-7v8xuicg 61 1 For for IN cord-280624-7v8xuicg 61 2 data datum NNS cord-280624-7v8xuicg 61 3 visualization visualization NN cord-280624-7v8xuicg 61 4 , , , cord-280624-7v8xuicg 61 5 Geneious Geneious NNP cord-280624-7v8xuicg 61 6 ( ( -LRB- cord-280624-7v8xuicg 61 7 version version NN cord-280624-7v8xuicg 61 8 7.1.8 7.1.8 CD cord-280624-7v8xuicg 61 9 ) ) -RRB- cord-280624-7v8xuicg 61 10 was be VBD cord-280624-7v8xuicg 61 11 used use VBN cord-280624-7v8xuicg 61 12 . . . cord-280624-7v8xuicg 62 1 To to TO cord-280624-7v8xuicg 62 2 avoid avoid VB cord-280624-7v8xuicg 62 3 losing lose VBG cord-280624-7v8xuicg 62 4 open open JJ cord-280624-7v8xuicg 62 5 reading reading NN cord-280624-7v8xuicg 62 6 frames frame NNS cord-280624-7v8xuicg 62 7 ( ( -LRB- cord-280624-7v8xuicg 62 8 ORFs ORFs NNP cord-280624-7v8xuicg 62 9 ) ) -RRB- cord-280624-7v8xuicg 62 10 within within IN cord-280624-7v8xuicg 62 11 different different JJ cord-280624-7v8xuicg 62 12 sequences sequence NNS cord-280624-7v8xuicg 62 13 , , , cord-280624-7v8xuicg 62 14 ORFs ORFs NNP cord-280624-7v8xuicg 62 15 were be VBD cord-280624-7v8xuicg 62 16 collected collect VBN cord-280624-7v8xuicg 62 17 by by IN cord-280624-7v8xuicg 62 18 retrieving retrieve VBG cord-280624-7v8xuicg 62 19 regions region NNS cord-280624-7v8xuicg 62 20 flanked flank VBN cord-280624-7v8xuicg 62 21 by by IN cord-280624-7v8xuicg 62 22 conserved conserved JJ cord-280624-7v8xuicg 62 23 sequences sequence NNS cord-280624-7v8xuicg 62 24 , , , cord-280624-7v8xuicg 62 25 as as IN cord-280624-7v8xuicg 62 26 shown show VBN cord-280624-7v8xuicg 62 27 in in IN cord-280624-7v8xuicg 62 28 ( ( -LRB- cord-280624-7v8xuicg 62 29 Table table NN cord-280624-7v8xuicg 62 30 1 1 CD cord-280624-7v8xuicg 62 31 ) ) -RRB- cord-280624-7v8xuicg 62 32 . . . cord-280624-7v8xuicg 63 1 Conserved conserved JJ cord-280624-7v8xuicg 63 2 sequences sequence NNS cord-280624-7v8xuicg 63 3 were be VBD cord-280624-7v8xuicg 63 4 obtained obtain VBN cord-280624-7v8xuicg 63 5 from from IN cord-280624-7v8xuicg 63 6 multiple multiple JJ cord-280624-7v8xuicg 63 7 sequence sequence NN cord-280624-7v8xuicg 63 8 alignment alignment NN cord-280624-7v8xuicg 63 9 of of IN cord-280624-7v8xuicg 63 10 308 308 CD cord-280624-7v8xuicg 63 11 complete complete JJ cord-280624-7v8xuicg 63 12 whole whole JJ cord-280624-7v8xuicg 63 13 MERS MERS NNP cord-280624-7v8xuicg 63 14 - - HYPH cord-280624-7v8xuicg 63 15 CoV cov NN cord-280624-7v8xuicg 63 16 genomes genome NNS cord-280624-7v8xuicg 63 17 . . . cord-280624-7v8xuicg 64 1 Different different JJ cord-280624-7v8xuicg 64 2 lengths length NNS cord-280624-7v8xuicg 64 3 of of IN cord-280624-7v8xuicg 64 4 ORF4b orf4b NN cord-280624-7v8xuicg 64 5 and and CC cord-280624-7v8xuicg 64 6 ORF8b ORF8b NNP cord-280624-7v8xuicg 64 7 were be VBD cord-280624-7v8xuicg 64 8 calculated calculate VBN cord-280624-7v8xuicg 64 9 at at IN cord-280624-7v8xuicg 64 10 its -PRON- PRP$ cord-280624-7v8xuicg 64 11 minimum minimum JJ cord-280624-7v8xuicg 64 12 possible possible JJ cord-280624-7v8xuicg 64 13 size size NN cord-280624-7v8xuicg 64 14 ( ( -LRB- cord-280624-7v8xuicg 64 15 300 300 CD cord-280624-7v8xuicg 64 16 nt nt JJ cord-280624-7v8xuicg 64 17 ) ) -RRB- cord-280624-7v8xuicg 64 18 , , , cord-280624-7v8xuicg 64 19 allowing allow VBG cord-280624-7v8xuicg 64 20 any any DT cord-280624-7v8xuicg 64 21 start start NN cord-280624-7v8xuicg 64 22 codon codon NN cord-280624-7v8xuicg 64 23 ( ( -LRB- cord-280624-7v8xuicg 64 24 ATG ATG NNP cord-280624-7v8xuicg 64 25 , , , cord-280624-7v8xuicg 64 26 TTG TTG NNP cord-280624-7v8xuicg 64 27 , , , cord-280624-7v8xuicg 64 28 or or CC cord-280624-7v8xuicg 64 29 CTG CTG NNP cord-280624-7v8xuicg 64 30 ) ) -RRB- cord-280624-7v8xuicg 64 31 to to TO cord-280624-7v8xuicg 64 32 initiate initiate VB cord-280624-7v8xuicg 64 33 the the DT cord-280624-7v8xuicg 64 34 ORF ORF NNP cord-280624-7v8xuicg 64 35 . . . cord-280624-7v8xuicg 65 1 Mapping map VBG cord-280624-7v8xuicg 65 2 the the DT cord-280624-7v8xuicg 65 3 cleavage cleavage NN cord-280624-7v8xuicg 65 4 sites site NNS cord-280624-7v8xuicg 65 5 of of IN cord-280624-7v8xuicg 65 6 the the DT cord-280624-7v8xuicg 65 7 NSPs nsp NNS cord-280624-7v8xuicg 65 8 among among IN cord-280624-7v8xuicg 65 9 gene-1 gene-1 NNP cord-280624-7v8xuicg 65 10 was be VBD cord-280624-7v8xuicg 65 11 carried carry VBN cord-280624-7v8xuicg 65 12 out out RP cord-280624-7v8xuicg 65 13 as as IN cord-280624-7v8xuicg 65 14 previously previously RB cord-280624-7v8xuicg 65 15 described describe VBN cord-280624-7v8xuicg 65 16 . . . cord-280624-7v8xuicg 66 1 21 21 CD cord-280624-7v8xuicg 66 2 _SP cord-280624-7v8xuicg 66 3 Phylogenetic Phylogenetic NNP cord-280624-7v8xuicg 66 4 trees tree NNS cord-280624-7v8xuicg 66 5 were be VBD cord-280624-7v8xuicg 66 6 constructed construct VBN cord-280624-7v8xuicg 66 7 using use VBG cord-280624-7v8xuicg 66 8 MEGA MEGA NNP cord-280624-7v8xuicg 66 9 X x NN cord-280624-7v8xuicg 66 10 software software NN cord-280624-7v8xuicg 66 11 22 22 CD cord-280624-7v8xuicg 66 12 using use VBG cord-280624-7v8xuicg 66 13 multiple multiple JJ cord-280624-7v8xuicg 66 14 sequence sequence NN cord-280624-7v8xuicg 66 15 alignment alignment NN cord-280624-7v8xuicg 66 16 of of IN cord-280624-7v8xuicg 66 17 the the DT cord-280624-7v8xuicg 66 18 whole whole JJ cord-280624-7v8xuicg 66 19 genome genome NN cord-280624-7v8xuicg 66 20 , , , cord-280624-7v8xuicg 66 21 ORF1ab ORF1ab NNP cord-280624-7v8xuicg 66 22 , , , cord-280624-7v8xuicg 66 23 S S NNP cord-280624-7v8xuicg 66 24 gene gene NN cord-280624-7v8xuicg 66 25 , , , cord-280624-7v8xuicg 66 26 ORF4b ORF4b NNP cord-280624-7v8xuicg 66 27 , , , cord-280624-7v8xuicg 66 28 ORF5 ORF5 NNP cord-280624-7v8xuicg 66 29 , , , cord-280624-7v8xuicg 66 30 E e NN cord-280624-7v8xuicg 66 31 gene gene NN cord-280624-7v8xuicg 66 32 , , , cord-280624-7v8xuicg 66 33 M M NNP cord-280624-7v8xuicg 66 34 gene gene NN cord-280624-7v8xuicg 66 35 , , , cord-280624-7v8xuicg 66 36 N n CD cord-280624-7v8xuicg 66 37 gene gene NN cord-280624-7v8xuicg 66 38 and and CC cord-280624-7v8xuicg 66 39 ORF8b orf8b CD cord-280624-7v8xuicg 66 40 sequences sequence NNS cord-280624-7v8xuicg 66 41 . . . cord-280624-7v8xuicg 67 1 The the DT cord-280624-7v8xuicg 67 2 trees tree NNS cord-280624-7v8xuicg 67 3 were be VBD cord-280624-7v8xuicg 67 4 constructed construct VBN cord-280624-7v8xuicg 67 5 using use VBG cord-280624-7v8xuicg 67 6 maximum maximum JJ cord-280624-7v8xuicg 67 7 likelihood likelihood NN cord-280624-7v8xuicg 67 8 methods method NNS cord-280624-7v8xuicg 67 9 and and CC cord-280624-7v8xuicg 67 10 the the DT cord-280624-7v8xuicg 67 11 Tamura Tamura NNP cord-280624-7v8xuicg 67 12 - - HYPH cord-280624-7v8xuicg 67 13 Nei Nei NNP cord-280624-7v8xuicg 67 14 model model NN cord-280624-7v8xuicg 67 15 . . . cord-280624-7v8xuicg 68 1 Bootstrap bootstrap NN cord-280624-7v8xuicg 68 2 analysis analysis NN cord-280624-7v8xuicg 68 3 ( ( -LRB- cord-280624-7v8xuicg 68 4 100 100 CD cord-280624-7v8xuicg 68 5 pseudo pseudo JJ cord-280624-7v8xuicg 68 6 - - HYPH cord-280624-7v8xuicg 68 7 replicates replicate NNS cord-280624-7v8xuicg 68 8 ) ) -RRB- cord-280624-7v8xuicg 68 9 was be VBD cord-280624-7v8xuicg 68 10 conducted conduct VBN cord-280624-7v8xuicg 68 11 to to TO cord-280624-7v8xuicg 68 12 evaluate evaluate VB cord-280624-7v8xuicg 68 13 the the DT cord-280624-7v8xuicg 68 14 statistical statistical JJ cord-280624-7v8xuicg 68 15 significance significance NN cord-280624-7v8xuicg 68 16 of of IN cord-280624-7v8xuicg 68 17 the the DT cord-280624-7v8xuicg 68 18 inferred infer VBN cord-280624-7v8xuicg 68 19 trees tree NNS cord-280624-7v8xuicg 68 20 , , , cord-280624-7v8xuicg 68 21 and and CC cord-280624-7v8xuicg 68 22 only only JJ cord-280624-7v8xuicg 68 23 values value NNS cord-280624-7v8xuicg 68 24 greater great JJR cord-280624-7v8xuicg 68 25 than than IN cord-280624-7v8xuicg 68 26 50 50 CD cord-280624-7v8xuicg 68 27 were be VBD cord-280624-7v8xuicg 68 28 displayed display VBN cord-280624-7v8xuicg 68 29 . . . cord-280624-7v8xuicg 69 1 Since since IN cord-280624-7v8xuicg 69 2 most most RBS cord-280624-7v8xuicg 69 3 isolated isolated JJ cord-280624-7v8xuicg 69 4 sequences sequence NNS cord-280624-7v8xuicg 69 5 did do VBD cord-280624-7v8xuicg 69 6 not not RB cord-280624-7v8xuicg 69 7 meet meet VB cord-280624-7v8xuicg 69 8 the the DT cord-280624-7v8xuicg 69 9 parameters parameter NNS cord-280624-7v8xuicg 69 10 used use VBN cord-280624-7v8xuicg 69 11 in in IN cord-280624-7v8xuicg 69 12 this this DT cord-280624-7v8xuicg 69 13 study study NN cord-280624-7v8xuicg 69 14 for for IN cord-280624-7v8xuicg 69 15 the the DT cord-280624-7v8xuicg 69 16 whole whole JJ cord-280624-7v8xuicg 69 17 - - HYPH cord-280624-7v8xuicg 69 18 genome genome NN cord-280624-7v8xuicg 69 19 sequences sequence NNS cord-280624-7v8xuicg 69 20 , , , cord-280624-7v8xuicg 69 21 we -PRON- PRP cord-280624-7v8xuicg 69 22 conducted conduct VBD cord-280624-7v8xuicg 69 23 the the DT cord-280624-7v8xuicg 69 24 analysis analysis NN cord-280624-7v8xuicg 69 25 on on IN cord-280624-7v8xuicg 69 26 individual individual JJ cord-280624-7v8xuicg 69 27 genes gene NNS cord-280624-7v8xuicg 69 28 . . . cord-280624-7v8xuicg 70 1 For for IN cord-280624-7v8xuicg 70 2 the the DT cord-280624-7v8xuicg 70 3 comparative comparative JJ cord-280624-7v8xuicg 70 4 study study NN cord-280624-7v8xuicg 70 5 of of IN cord-280624-7v8xuicg 70 6 phylogenetic phylogenetic JJ cord-280624-7v8xuicg 70 7 trees tree NNS cord-280624-7v8xuicg 70 8 , , , cord-280624-7v8xuicg 70 9 we -PRON- PRP cord-280624-7v8xuicg 70 10 initially initially RB cord-280624-7v8xuicg 70 11 considered consider VBD cord-280624-7v8xuicg 70 12 493 493 CD cord-280624-7v8xuicg 70 13 sequences sequence NNS cord-280624-7v8xuicg 70 14 greater great JJR cord-280624-7v8xuicg 70 15 than than IN cord-280624-7v8xuicg 70 16 30 30 CD cord-280624-7v8xuicg 70 17 kb kb NNS cord-280624-7v8xuicg 70 18 since since IN cord-280624-7v8xuicg 70 19 most most JJS cord-280624-7v8xuicg 70 20 of of IN cord-280624-7v8xuicg 70 21 the the DT cord-280624-7v8xuicg 70 22 isolated isolate VBN cord-280624-7v8xuicg 70 23 sequences sequence NNS cord-280624-7v8xuicg 70 24 ( ( -LRB- cord-280624-7v8xuicg 70 25 especially especially RB cord-280624-7v8xuicg 70 26 isolates isolate VBZ cord-280624-7v8xuicg 70 27 from from IN cord-280624-7v8xuicg 70 28 African african JJ cord-280624-7v8xuicg 70 29 camels camel NNS cord-280624-7v8xuicg 70 30 ) ) -RRB- cord-280624-7v8xuicg 70 31 did do VBD cord-280624-7v8xuicg 70 32 not not RB cord-280624-7v8xuicg 70 33 meet meet VB cord-280624-7v8xuicg 70 34 the the DT cord-280624-7v8xuicg 70 35 parameters parameter NNS cord-280624-7v8xuicg 70 36 used use VBN cord-280624-7v8xuicg 70 37 in in IN cord-280624-7v8xuicg 70 38 this this DT cord-280624-7v8xuicg 70 39 study study NN cord-280624-7v8xuicg 70 40 for for IN cord-280624-7v8xuicg 70 41 the the DT cord-280624-7v8xuicg 70 42 whole whole JJ cord-280624-7v8xuicg 70 43 - - HYPH cord-280624-7v8xuicg 70 44 genome genome NN cord-280624-7v8xuicg 70 45 sequences sequence NNS cord-280624-7v8xuicg 70 46 . . . cord-280624-7v8xuicg 71 1 Then then RB cord-280624-7v8xuicg 71 2 , , , cord-280624-7v8xuicg 71 3 to to TO cord-280624-7v8xuicg 71 4 make make VB cord-280624-7v8xuicg 71 5 the the DT cord-280624-7v8xuicg 71 6 tree tree NN cord-280624-7v8xuicg 71 7 much much RB cord-280624-7v8xuicg 71 8 simpler simple JJR cord-280624-7v8xuicg 71 9 and and CC cord-280624-7v8xuicg 71 10 easily easily RB cord-280624-7v8xuicg 71 11 readable readable JJ cord-280624-7v8xuicg 71 12 , , , cord-280624-7v8xuicg 71 13 we -PRON- PRP cord-280624-7v8xuicg 71 14 narrowed narrow VBD cord-280624-7v8xuicg 71 15 We -PRON- PRP cord-280624-7v8xuicg 71 16 used use VBD cord-280624-7v8xuicg 71 17 308 308 CD cord-280624-7v8xuicg 71 18 full full JJ cord-280624-7v8xuicg 71 19 - - HYPH cord-280624-7v8xuicg 71 20 length length NN cord-280624-7v8xuicg 71 21 genome genome NN cord-280624-7v8xuicg 71 22 sequences sequence NNS cord-280624-7v8xuicg 71 23 after after IN cord-280624-7v8xuicg 71 24 applying apply VBG cord-280624-7v8xuicg 71 25 filteration filteration NN cord-280624-7v8xuicg 71 26 parameters parameter NNS cord-280624-7v8xuicg 71 27 . . . cord-280624-7v8xuicg 72 1 All all DT cord-280624-7v8xuicg 72 2 relevant relevant JJ cord-280624-7v8xuicg 72 3 data datum NNS cord-280624-7v8xuicg 72 4 of of IN cord-280624-7v8xuicg 72 5 these these DT cord-280624-7v8xuicg 72 6 sequences sequence NNS cord-280624-7v8xuicg 72 7 are be VBP cord-280624-7v8xuicg 72 8 summarized summarize VBN cord-280624-7v8xuicg 72 9 in in IN cord-280624-7v8xuicg 72 10 Table Table NNP cord-280624-7v8xuicg 72 11 S1 S1 NNP cord-280624-7v8xuicg 72 12 . . . cord-280624-7v8xuicg 73 1 ( ( -LRB- cord-280624-7v8xuicg 73 2 Table table NN cord-280624-7v8xuicg 73 3 4 4 CD cord-280624-7v8xuicg 73 4 ) ) -RRB- cord-280624-7v8xuicg 73 5 . . . cord-280624-7v8xuicg 73 6 _SP cord-280624-7v8xuicg 74 1 ORF1ab ORF1ab NNP cord-280624-7v8xuicg 74 2 consists consist VBZ cord-280624-7v8xuicg 74 3 of of IN cord-280624-7v8xuicg 74 4 two two CD cord-280624-7v8xuicg 74 5 overlapping overlap VBG cord-280624-7v8xuicg 74 6 ORFs orfs NN cord-280624-7v8xuicg 74 7 ( ( -LRB- cord-280624-7v8xuicg 74 8 ORF-1a ORF-1a NNP cord-280624-7v8xuicg 74 9 and and CC cord-280624-7v8xuicg 74 10 ORF-1b ORF-1b NNP cord-280624-7v8xuicg 74 11 ) ) -RRB- cord-280624-7v8xuicg 74 12 . . . cord-280624-7v8xuicg 75 1 The the DT cord-280624-7v8xuicg 75 2 ORF-1b ORF-1b NNP cord-280624-7v8xuicg 75 3 is be VBZ cord-280624-7v8xuicg 75 4 produced produce VBN cord-280624-7v8xuicg 75 5 by by IN cord-280624-7v8xuicg 75 6 ribosomal ribosomal JJ cord-280624-7v8xuicg 75 7 frameshifting frameshifting NN cord-280624-7v8xuicg 75 8 in in IN cord-280624-7v8xuicg 75 9 which which WDT cord-280624-7v8xuicg 75 10 the the DT cord-280624-7v8xuicg 75 11 ribosome ribosome NN cord-280624-7v8xuicg 75 12 steps step VBZ cord-280624-7v8xuicg 75 13 back back RB cord-280624-7v8xuicg 75 14 one one CD cord-280624-7v8xuicg 75 15 nucleotide nucleotide NN cord-280624-7v8xuicg 75 16 and and CC cord-280624-7v8xuicg 75 17 continues continue VBZ cord-280624-7v8xuicg 75 18 reading read VBG cord-280624-7v8xuicg 75 19 and and CC cord-280624-7v8xuicg 75 20 producing produce VBG cord-280624-7v8xuicg 75 21 ORF-1b ORF-1b NNP cord-280624-7v8xuicg 75 22 ( ( -LRB- cord-280624-7v8xuicg 75 23 Figure figure NN cord-280624-7v8xuicg 75 24 1 1 CD cord-280624-7v8xuicg 75 25 ) ) -RRB- cord-280624-7v8xuicg 75 26 . . . cord-280624-7v8xuicg 76 1 We -PRON- PRP cord-280624-7v8xuicg 76 2 analyzed analyze VBD cord-280624-7v8xuicg 76 3 544 544 CD cord-280624-7v8xuicg 76 4 sequences sequence NNS cord-280624-7v8xuicg 76 5 of of IN cord-280624-7v8xuicg 76 6 ORF1ab ORF1ab NNP cord-280624-7v8xuicg 76 7 ( ( -LRB- cord-280624-7v8xuicg 76 8 Table Table NNP cord-280624-7v8xuicg 76 9 S1 S1 NNP cord-280624-7v8xuicg 76 10 ) ) -RRB- cord-280624-7v8xuicg 76 11 . . . cord-280624-7v8xuicg 77 1 ORF1ab ORF1ab NNP cord-280624-7v8xuicg 77 2 is be VBZ cord-280624-7v8xuicg 77 3 21 21 CD cord-280624-7v8xuicg 77 4 236 236 CD cord-280624-7v8xuicg 77 5 nt nt RB cord-280624-7v8xuicg 77 6 in in IN cord-280624-7v8xuicg 77 7 length length NN cord-280624-7v8xuicg 77 8 , , , cord-280624-7v8xuicg 77 9 and and CC cord-280624-7v8xuicg 77 10 the the DT cord-280624-7v8xuicg 77 11 position position NN cord-280624-7v8xuicg 77 12 of of IN cord-280624-7v8xuicg 77 13 the the DT cord-280624-7v8xuicg 77 14 ribosomal ribosomal JJ cord-280624-7v8xuicg 77 15 frameshifting frameshifting NN cord-280624-7v8xuicg 77 16 is be VBZ cord-280624-7v8xuicg 77 17 located locate VBN cord-280624-7v8xuicg 77 18 at at IN cord-280624-7v8xuicg 77 19 13 13 CD cord-280624-7v8xuicg 77 20 433 433 CD cord-280624-7v8xuicg 77 21 nt nt NN cord-280624-7v8xuicg 77 22 of of IN cord-280624-7v8xuicg 77 23 JX869059 JX869059 NNP cord-280624-7v8xuicg 77 24 . . . cord-280624-7v8xuicg 78 1 Distribution distribution NN cord-280624-7v8xuicg 78 2 of of IN cord-280624-7v8xuicg 78 3 polymorphisms polymorphism NNS cord-280624-7v8xuicg 78 4 ( ( -LRB- cord-280624-7v8xuicg 78 5 SNPs snp NNS cord-280624-7v8xuicg 78 6 found find VBD cord-280624-7v8xuicg 78 7 in in IN cord-280624-7v8xuicg 78 8 more more JJR cord-280624-7v8xuicg 78 9 than than IN cord-280624-7v8xuicg 78 10 one one CD cord-280624-7v8xuicg 78 11 strain strain NN cord-280624-7v8xuicg 78 12 in in IN cord-280624-7v8xuicg 78 13 a a DT cord-280624-7v8xuicg 78 14 50-bp 50-bp CD cord-280624-7v8xuicg 78 15 sliding slide VBG cord-280624-7v8xuicg 78 16 window window NN cord-280624-7v8xuicg 78 17 ) ) -RRB- cord-280624-7v8xuicg 78 18 showed show VBD cord-280624-7v8xuicg 78 19 that that IN cord-280624-7v8xuicg 78 20 SNP SNP NNP cord-280624-7v8xuicg 78 21 density density NN cord-280624-7v8xuicg 78 22 in in IN cord-280624-7v8xuicg 78 23 ORF1ab ORF1ab NNP cord-280624-7v8xuicg 78 24 varies vary VBZ cord-280624-7v8xuicg 78 25 from from IN cord-280624-7v8xuicg 78 26 0 0 CD cord-280624-7v8xuicg 78 27 to to IN cord-280624-7v8xuicg 78 28 11 11 CD cord-280624-7v8xuicg 78 29 ( ( -LRB- cord-280624-7v8xuicg 78 30 Figure figure NN cord-280624-7v8xuicg 78 31 S1A s1a NN cord-280624-7v8xuicg 78 32 ) ) -RRB- cord-280624-7v8xuicg 78 33 . . . cord-280624-7v8xuicg 79 1 From from IN cord-280624-7v8xuicg 79 2 multiple multiple JJ cord-280624-7v8xuicg 79 3 sequence sequence NN cord-280624-7v8xuicg 79 4 alignment alignment NN cord-280624-7v8xuicg 79 5 , , , cord-280624-7v8xuicg 79 6 we -PRON- PRP cord-280624-7v8xuicg 79 7 identified identify VBD cord-280624-7v8xuicg 79 8 eight eight CD cord-280624-7v8xuicg 79 9 variants variant NNS cord-280624-7v8xuicg 79 10 seem seem VBP cord-280624-7v8xuicg 79 11 to to TO cord-280624-7v8xuicg 79 12 be be VB cord-280624-7v8xuicg 79 13 restricted restrict VBN cord-280624-7v8xuicg 79 14 to to IN cord-280624-7v8xuicg 79 15 MERS MERS NNP cord-280624-7v8xuicg 79 16 - - HYPH cord-280624-7v8xuicg 79 17 CoV CoV NNP cord-280624-7v8xuicg 79 18 isolated isolate VBN cord-280624-7v8xuicg 79 19 from from IN cord-280624-7v8xuicg 79 20 African african JJ cord-280624-7v8xuicg 79 21 camels camel NNS cord-280624-7v8xuicg 79 22 . . . cord-280624-7v8xuicg 80 1 All all PDT cord-280624-7v8xuicg 80 2 these these DT cord-280624-7v8xuicg 80 3 variants variant NNS cord-280624-7v8xuicg 80 4 exited exit VBD cord-280624-7v8xuicg 80 5 in in IN cord-280624-7v8xuicg 80 6 studied study VBN cord-280624-7v8xuicg 80 7 African african JJ cord-280624-7v8xuicg 80 8 camels camel NNS cord-280624-7v8xuicg 80 9 only only RB cord-280624-7v8xuicg 80 10 ( ( -LRB- cord-280624-7v8xuicg 80 11 Table Table NNP cord-280624-7v8xuicg 80 12 S2 S2 NNP cord-280624-7v8xuicg 80 13 ) ) -RRB- cord-280624-7v8xuicg 80 14 . . . cord-280624-7v8xuicg 81 1 Table table NN cord-280624-7v8xuicg 81 2 3 3 CD cord-280624-7v8xuicg 81 3 ) ) -RRB- cord-280624-7v8xuicg 81 4 . . . cord-280624-7v8xuicg 82 1 Details detail NNS cord-280624-7v8xuicg 82 2 about about IN cord-280624-7v8xuicg 82 3 the the DT cord-280624-7v8xuicg 82 4 NSPs nsp NNS cord-280624-7v8xuicg 82 5 , , , cord-280624-7v8xuicg 82 6 their -PRON- PRP$ cord-280624-7v8xuicg 82 7 locations location NNS cord-280624-7v8xuicg 82 8 , , , cord-280624-7v8xuicg 82 9 as as RB cord-280624-7v8xuicg 82 10 well well RB cord-280624-7v8xuicg 82 11 as as IN cord-280624-7v8xuicg 82 12 sizes size NNS cord-280624-7v8xuicg 82 13 , , , cord-280624-7v8xuicg 82 14 are be VBP cord-280624-7v8xuicg 82 15 shown show VBN cord-280624-7v8xuicg 82 16 in in IN cord-280624-7v8xuicg 82 17 Table Table NNP cord-280624-7v8xuicg 82 18 2 2 CD cord-280624-7v8xuicg 82 19 . . . cord-280624-7v8xuicg 83 1 We -PRON- PRP cord-280624-7v8xuicg 83 2 analyzed analyze VBD cord-280624-7v8xuicg 83 3 744 744 CD cord-280624-7v8xuicg 83 4 of of IN cord-280624-7v8xuicg 83 5 the the DT cord-280624-7v8xuicg 83 6 S S NNP cord-280624-7v8xuicg 83 7 - - HYPH cord-280624-7v8xuicg 83 8 gene gene NN cord-280624-7v8xuicg 83 9 sequences sequence NNS cord-280624-7v8xuicg 83 10 ( ( -LRB- cord-280624-7v8xuicg 83 11 Table Table NNP cord-280624-7v8xuicg 83 12 S1 S1 NNP cord-280624-7v8xuicg 83 13 ) ) -RRB- cord-280624-7v8xuicg 83 14 . . . cord-280624-7v8xuicg 84 1 The the DT cord-280624-7v8xuicg 84 2 full full JJ cord-280624-7v8xuicg 84 3 - - HYPH cord-280624-7v8xuicg 84 4 length length NN cord-280624-7v8xuicg 84 5 of of IN cord-280624-7v8xuicg 84 6 the the DT cord-280624-7v8xuicg 84 7 S S NNP cord-280624-7v8xuicg 84 8 gene gene NN cord-280624-7v8xuicg 84 9 is be VBZ cord-280624-7v8xuicg 84 10 about about RB cord-280624-7v8xuicg 84 11 4062 4062 CD cord-280624-7v8xuicg 84 12 nt nt RB cord-280624-7v8xuicg 84 13 . . . cord-280624-7v8xuicg 85 1 The the DT cord-280624-7v8xuicg 85 2 organization organization NN cord-280624-7v8xuicg 85 3 of of IN cord-280624-7v8xuicg 85 4 the the DT cord-280624-7v8xuicg 85 5 MERS MERS NNP cord-280624-7v8xuicg 85 6 - - HYPH cord-280624-7v8xuicg 85 7 CoV CoV NNP cord-280624-7v8xuicg 85 8 - - HYPH cord-280624-7v8xuicg 85 9 S s NN cord-280624-7v8xuicg 85 10 gene gene NN cord-280624-7v8xuicg 85 11 is be VBZ cord-280624-7v8xuicg 85 12 described describe VBN cord-280624-7v8xuicg 85 13 in in IN cord-280624-7v8xuicg 85 14 Figure figure NN cord-280624-7v8xuicg 85 15 1B 1b CD cord-280624-7v8xuicg 85 16 ( ( -LRB- cord-280624-7v8xuicg 85 17 Table table NN cord-280624-7v8xuicg 85 18 3 3 CD cord-280624-7v8xuicg 85 19 ) ) -RRB- cord-280624-7v8xuicg 85 20 . . . cord-280624-7v8xuicg 86 1 We -PRON- PRP cord-280624-7v8xuicg 86 2 conducted conduct VBD cord-280624-7v8xuicg 86 3 an an DT cord-280624-7v8xuicg 86 4 SNP SNP NNP cord-280624-7v8xuicg 86 5 density density NN cord-280624-7v8xuicg 86 6 analysis analysis NN cord-280624-7v8xuicg 86 7 to to TO cord-280624-7v8xuicg 86 8 test test VB cord-280624-7v8xuicg 86 9 whether whether IN cord-280624-7v8xuicg 86 10 the the DT cord-280624-7v8xuicg 86 11 three three CD cord-280624-7v8xuicg 86 12 observed observed JJ cord-280624-7v8xuicg 86 13 variants variant NNS cord-280624-7v8xuicg 86 14 of of IN cord-280624-7v8xuicg 86 15 the the DT cord-280624-7v8xuicg 86 16 S S NNP cord-280624-7v8xuicg 86 17 gene gene NN cord-280624-7v8xuicg 86 18 in in IN cord-280624-7v8xuicg 86 19 African african JJ cord-280624-7v8xuicg 86 20 camel camel NN cord-280624-7v8xuicg 86 21 samples sample NNS cord-280624-7v8xuicg 86 22 were be VBD cord-280624-7v8xuicg 86 23 not not RB cord-280624-7v8xuicg 86 24 in in IN cord-280624-7v8xuicg 86 25 a a DT cord-280624-7v8xuicg 86 26 highly highly RB cord-280624-7v8xuicg 86 27 variable variable JJ cord-280624-7v8xuicg 86 28 region region NN cord-280624-7v8xuicg 86 29 . . . cord-280624-7v8xuicg 87 1 The the DT cord-280624-7v8xuicg 87 2 distribution distribution NN cord-280624-7v8xuicg 87 3 of of IN cord-280624-7v8xuicg 87 4 polymorphisms polymorphism NNS cord-280624-7v8xuicg 87 5 ( ( -LRB- cord-280624-7v8xuicg 87 6 SNPs snp NNS cord-280624-7v8xuicg 87 7 found find VBD cord-280624-7v8xuicg 87 8 in in IN cord-280624-7v8xuicg 87 9 more more JJR cord-280624-7v8xuicg 87 10 than than IN cord-280624-7v8xuicg 87 11 one one CD cord-280624-7v8xuicg 87 12 strain strain NN cord-280624-7v8xuicg 87 13 in in IN cord-280624-7v8xuicg 87 14 a a DT cord-280624-7v8xuicg 87 15 50-bp 50-bp CD cord-280624-7v8xuicg 87 16 sliding slide VBG cord-280624-7v8xuicg 87 17 window window NN cord-280624-7v8xuicg 87 18 ) ) -RRB- cord-280624-7v8xuicg 87 19 showed show VBD cord-280624-7v8xuicg 87 20 that that IN cord-280624-7v8xuicg 87 21 SNP SNP NNP cord-280624-7v8xuicg 87 22 density density NN cord-280624-7v8xuicg 87 23 in in IN cord-280624-7v8xuicg 87 24 S S NNP cord-280624-7v8xuicg 87 25 gene gene NN cord-280624-7v8xuicg 87 26 varies vary VBZ cord-280624-7v8xuicg 87 27 from from IN cord-280624-7v8xuicg 87 28 0 0 CD cord-280624-7v8xuicg 87 29 to to IN cord-280624-7v8xuicg 87 30 12 12 CD cord-280624-7v8xuicg 87 31 ( ( -LRB- cord-280624-7v8xuicg 87 32 Figure figure NN cord-280624-7v8xuicg 87 33 S2 s2 NN cord-280624-7v8xuicg 87 34 ) ) -RRB- cord-280624-7v8xuicg 87 35 . . . cord-280624-7v8xuicg 88 1 The the DT cord-280624-7v8xuicg 88 2 variant variant NN cord-280624-7v8xuicg 88 3 V26A V26A NNP cord-280624-7v8xuicg 88 4 is be VBZ cord-280624-7v8xuicg 88 5 located locate VBN cord-280624-7v8xuicg 88 6 in in IN cord-280624-7v8xuicg 88 7 a a DT cord-280624-7v8xuicg 88 8 region region NN cord-280624-7v8xuicg 88 9 with with IN cord-280624-7v8xuicg 88 10 a a DT cord-280624-7v8xuicg 88 11 SNP SNP NNP cord-280624-7v8xuicg 88 12 density density NN cord-280624-7v8xuicg 88 13 of of IN cord-280624-7v8xuicg 88 14 five five CD cord-280624-7v8xuicg 88 15 , , , cord-280624-7v8xuicg 88 16 while while IN cord-280624-7v8xuicg 88 17 both both CC cord-280624-7v8xuicg 88 18 R1020Q r1020q CD cord-280624-7v8xuicg 89 1 and and CC cord-280624-7v8xuicg 90 1 A1158S A1158S NNP cord-280624-7v8xuicg 90 2 / / SYM cord-280624-7v8xuicg 90 3 L l NN cord-280624-7v8xuicg 90 4 substitutions substitution NNS cord-280624-7v8xuicg 90 5 are be VBP cord-280624-7v8xuicg 90 6 located locate VBN cord-280624-7v8xuicg 90 7 in in IN cord-280624-7v8xuicg 90 8 a a DT cord-280624-7v8xuicg 90 9 region region NN cord-280624-7v8xuicg 90 10 of of IN cord-280624-7v8xuicg 90 11 low low JJ cord-280624-7v8xuicg 90 12 SNP SNP NNP cord-280624-7v8xuicg 90 13 density density NN cord-280624-7v8xuicg 90 14 ( ( -LRB- cord-280624-7v8xuicg 90 15 SNP SNP NNP cord-280624-7v8xuicg 90 16 density density NN cord-280624-7v8xuicg 90 17 = = SYM cord-280624-7v8xuicg 90 18 2 2 CD cord-280624-7v8xuicg 90 19 ) ) -RRB- cord-280624-7v8xuicg 90 20 . . . cord-280624-7v8xuicg 91 1 The the DT cord-280624-7v8xuicg 91 2 total total JJ cord-280624-7v8xuicg 91 3 number number NN cord-280624-7v8xuicg 91 4 of of IN cord-280624-7v8xuicg 91 5 different different JJ cord-280624-7v8xuicg 91 6 nucleotides nucleotide NNS cord-280624-7v8xuicg 91 7 between between IN cord-280624-7v8xuicg 91 8 samples sample NNS cord-280624-7v8xuicg 91 9 in in IN cord-280624-7v8xuicg 91 10 the the DT cord-280624-7v8xuicg 91 11 phylogenetic phylogenetic JJ cord-280624-7v8xuicg 91 12 tree tree NN cord-280624-7v8xuicg 91 13 of of IN cord-280624-7v8xuicg 91 14 the the DT cord-280624-7v8xuicg 91 15 S S NNP cord-280624-7v8xuicg 91 16 gene gene NN cord-280624-7v8xuicg 91 17 sequences sequence NNS cord-280624-7v8xuicg 91 18 is be VBZ cord-280624-7v8xuicg 91 19 shown show VBN cord-280624-7v8xuicg 91 20 in in IN cord-280624-7v8xuicg 91 21 Table Table NNP cord-280624-7v8xuicg 91 22 S2 S2 NNP cord-280624-7v8xuicg 91 23 . . . cord-280624-7v8xuicg 92 1 The the DT cord-280624-7v8xuicg 92 2 phylogenetic phylogenetic JJ cord-280624-7v8xuicg 92 3 tree tree NN cord-280624-7v8xuicg 92 4 of of IN cord-280624-7v8xuicg 92 5 the the DT cord-280624-7v8xuicg 92 6 57 57 CD cord-280624-7v8xuicg 92 7 MERS MERS NNP cord-280624-7v8xuicg 92 8 - - HYPH cord-280624-7v8xuicg 92 9 CoV CoV NNP cord-280624-7v8xuicg 92 10 of of IN cord-280624-7v8xuicg 92 11 S S NNP cord-280624-7v8xuicg 92 12 gene gene NN cord-280624-7v8xuicg 92 13 sequences sequence NNS cord-280624-7v8xuicg 92 14 is be VBZ cord-280624-7v8xuicg 92 15 presented present VBN cord-280624-7v8xuicg 92 16 in in IN cord-280624-7v8xuicg 92 17 Figure Figure NNP cord-280624-7v8xuicg 92 18 2C 2c NN cord-280624-7v8xuicg 92 19 . . . cord-280624-7v8xuicg 93 1 Compared compare VBN cord-280624-7v8xuicg 93 2 to to IN cord-280624-7v8xuicg 93 3 the the DT cord-280624-7v8xuicg 93 4 phylogenetic phylogenetic JJ cord-280624-7v8xuicg 93 5 tree tree NN cord-280624-7v8xuicg 93 6 of of IN cord-280624-7v8xuicg 93 7 MERS MERS NNP cord-280624-7v8xuicg 93 8 - - HYPH cord-280624-7v8xuicg 93 9 CoV CoV NNP cord-280624-7v8xuicg 93 10 whole whole JJ cord-280624-7v8xuicg 93 11 - - HYPH cord-280624-7v8xuicg 93 12 genome genome NN cord-280624-7v8xuicg 93 13 and and CC cord-280624-7v8xuicg 93 14 ORF1ab ORF1ab NNP cord-280624-7v8xuicg 93 15 sequences sequence NNS cord-280624-7v8xuicg 94 1 ( ( -LRB- cord-280624-7v8xuicg 94 2 Figure figure NN cord-280624-7v8xuicg 94 3 2A 2a CD cord-280624-7v8xuicg 94 4 ( ( -LRB- cord-280624-7v8xuicg 94 5 Table Table NNP cord-280624-7v8xuicg 94 6 S1 S1 NNP cord-280624-7v8xuicg 94 7 ) ) -RRB- cord-280624-7v8xuicg 94 8 . . . cord-280624-7v8xuicg 95 1 There there EX cord-280624-7v8xuicg 95 2 was be VBD cord-280624-7v8xuicg 95 3 no no DT cord-280624-7v8xuicg 95 4 sample sample NN cord-280624-7v8xuicg 95 5 observed observe VBN cord-280624-7v8xuicg 95 6 with with IN cord-280624-7v8xuicg 95 7 the the DT cord-280624-7v8xuicg 95 8 two two CD cord-280624-7v8xuicg 95 9 mutations mutation NNS cord-280624-7v8xuicg 95 10 ( ( -LRB- cord-280624-7v8xuicg 95 11 I529 I529 `` cord-280624-7v8xuicg 95 12 T T NNP cord-280624-7v8xuicg 95 13 and and CC cord-280624-7v8xuicg 95 14 D510 D510 NNP cord-280624-7v8xuicg 95 15 G G NNP cord-280624-7v8xuicg 95 16 ) ) -RRB- cord-280624-7v8xuicg 95 17 at at IN cord-280624-7v8xuicg 95 18 the the DT cord-280624-7v8xuicg 95 19 same same JJ cord-280624-7v8xuicg 95 20 time time NN cord-280624-7v8xuicg 95 21 . . . cord-280624-7v8xuicg 96 1 In in IN cord-280624-7v8xuicg 96 2 the the DT cord-280624-7v8xuicg 96 3 case case NN cord-280624-7v8xuicg 96 4 of of IN cord-280624-7v8xuicg 96 5 ORF-3 ORF-3 NNP cord-280624-7v8xuicg 96 6 , , , cord-280624-7v8xuicg 96 7 we -PRON- PRP cord-280624-7v8xuicg 96 8 analyzed analyze VBD cord-280624-7v8xuicg 96 9 566 566 CD cord-280624-7v8xuicg 96 10 sequences sequence NNS cord-280624-7v8xuicg 96 11 ( ( -LRB- cord-280624-7v8xuicg 96 12 Table Table NNP cord-280624-7v8xuicg 96 13 S1 S1 NNP cord-280624-7v8xuicg 96 14 ) ) -RRB- cord-280624-7v8xuicg 96 15 . . . cord-280624-7v8xuicg 97 1 The the DT cord-280624-7v8xuicg 97 2 length length NN cord-280624-7v8xuicg 97 3 of of IN cord-280624-7v8xuicg 97 4 ORF3 ORF3 NNP cord-280624-7v8xuicg 97 5 gene gene NN cord-280624-7v8xuicg 97 6 is be VBZ cord-280624-7v8xuicg 97 7 312-nt 312-nt CD cord-280624-7v8xuicg 97 8 . . . cord-280624-7v8xuicg 98 1 However however RB cord-280624-7v8xuicg 98 2 , , , cord-280624-7v8xuicg 98 3 in in IN cord-280624-7v8xuicg 98 4 some some DT cord-280624-7v8xuicg 98 5 submissions submission NNS cord-280624-7v8xuicg 98 6 , , , cord-280624-7v8xuicg 98 7 we -PRON- PRP cord-280624-7v8xuicg 98 8 found find VBD cord-280624-7v8xuicg 98 9 truncated truncated JJ cord-280624-7v8xuicg 98 10 versions version NNS cord-280624-7v8xuicg 98 11 of of IN cord-280624-7v8xuicg 98 12 the the DT cord-280624-7v8xuicg 98 13 encoded encode VBN cord-280624-7v8xuicg 98 14 protein protein NN cord-280624-7v8xuicg 98 15 of of IN cord-280624-7v8xuicg 98 16 this this DT cord-280624-7v8xuicg 98 17 ORF ORF NNP cord-280624-7v8xuicg 98 18 due due IN cord-280624-7v8xuicg 98 19 to to IN cord-280624-7v8xuicg 98 20 deletions deletion NNS cord-280624-7v8xuicg 98 21 varying vary VBG cord-280624-7v8xuicg 98 22 from from IN cord-280624-7v8xuicg 98 23 9-nt 9-nt CD cord-280624-7v8xuicg 98 24 to to IN cord-280624-7v8xuicg 98 25 41-nt 41-nt CD cord-280624-7v8xuicg 98 26 ( ( -LRB- cord-280624-7v8xuicg 98 27 Table table NN cord-280624-7v8xuicg 98 28 3 3 CD cord-280624-7v8xuicg 98 29 ) ) -RRB- cord-280624-7v8xuicg 98 30 . . . cord-280624-7v8xuicg 99 1 Two two CD cord-280624-7v8xuicg 99 2 variants variant NNS cord-280624-7v8xuicg 99 3 were be VBD cord-280624-7v8xuicg 99 4 _SP cord-280624-7v8xuicg 100 1 The the DT cord-280624-7v8xuicg 100 2 ORF-4 ORF-4 NNP cord-280624-7v8xuicg 100 3 mainly mainly RB cord-280624-7v8xuicg 100 4 consists consist VBZ cord-280624-7v8xuicg 100 5 of of IN cord-280624-7v8xuicg 100 6 two two CD cord-280624-7v8xuicg 100 7 overlapping overlap VBG cord-280624-7v8xuicg 100 8 ORFs orfs NN cord-280624-7v8xuicg 100 9 ( ( -LRB- cord-280624-7v8xuicg 100 10 ORF-4a orf-4a NN cord-280624-7v8xuicg 100 11 and and CC cord-280624-7v8xuicg 100 12 4b 4b CD cord-280624-7v8xuicg 100 13 ) ) -RRB- cord-280624-7v8xuicg 100 14 . . . cord-280624-7v8xuicg 101 1 In in IN cord-280624-7v8xuicg 101 2 the the DT cord-280624-7v8xuicg 101 3 case case NN cord-280624-7v8xuicg 101 4 of of IN cord-280624-7v8xuicg 101 5 ORF-4a ORF-4a NNP cord-280624-7v8xuicg 101 6 , , , cord-280624-7v8xuicg 101 7 we -PRON- PRP cord-280624-7v8xuicg 101 8 analyzed analyze VBD cord-280624-7v8xuicg 101 9 568 568 CD cord-280624-7v8xuicg 101 10 sequences sequence NNS cord-280624-7v8xuicg 101 11 ( ( -LRB- cord-280624-7v8xuicg 101 12 Table Table NNP cord-280624-7v8xuicg 101 13 S1 S1 NNP cord-280624-7v8xuicg 101 14 ) ) -RRB- cord-280624-7v8xuicg 101 15 . . . cord-280624-7v8xuicg 102 1 The the DT cord-280624-7v8xuicg 102 2 ORF4a orf4a JJ cord-280624-7v8xuicg 102 3 gene gene NN cord-280624-7v8xuicg 102 4 is be VBZ cord-280624-7v8xuicg 102 5 330-nt 330-nt CD cord-280624-7v8xuicg 102 6 in in IN cord-280624-7v8xuicg 102 7 length length NN cord-280624-7v8xuicg 102 8 , , , cord-280624-7v8xuicg 102 9 and and CC cord-280624-7v8xuicg 102 10 there there EX cord-280624-7v8xuicg 102 11 is be VBZ cord-280624-7v8xuicg 102 12 89-nt 89-nt CD cord-280624-7v8xuicg 102 13 overlapping overlap VBG cord-280624-7v8xuicg 102 14 between between IN cord-280624-7v8xuicg 102 15 ORF4a orf4a JJ cord-280624-7v8xuicg 102 16 and and CC cord-280624-7v8xuicg 102 17 ORF4b orf4b JJ cord-280624-7v8xuicg 102 18 genes gene NNS cord-280624-7v8xuicg 102 19 . . . cord-280624-7v8xuicg 103 1 The the DT cord-280624-7v8xuicg 103 2 ORF4a ORF4a NNP cord-280624-7v8xuicg 103 3 is be VBZ cord-280624-7v8xuicg 103 4 highly highly RB cord-280624-7v8xuicg 103 5 conserved conserve VBN cord-280624-7v8xuicg 103 6 , , , cord-280624-7v8xuicg 103 7 but but CC cord-280624-7v8xuicg 103 8 SNP SNP NNP cord-280624-7v8xuicg 103 9 density density NN cord-280624-7v8xuicg 103 10 increases increase VBZ cord-280624-7v8xuicg 103 11 in in IN cord-280624-7v8xuicg 103 12 the the DT cord-280624-7v8xuicg 103 13 last last JJ cord-280624-7v8xuicg 103 14 45 45 CD cord-280624-7v8xuicg 103 15 nt nt NN cord-280624-7v8xuicg 103 16 ( ( -LRB- cord-280624-7v8xuicg 103 17 data datum NNS cord-280624-7v8xuicg 103 18 not not RB cord-280624-7v8xuicg 103 19 shown show VBN cord-280624-7v8xuicg 103 20 ) ) -RRB- cord-280624-7v8xuicg 103 21 . . . cord-280624-7v8xuicg 104 1 We -PRON- PRP cord-280624-7v8xuicg 104 2 analyzed analyze VBD cord-280624-7v8xuicg 104 3 575 575 CD cord-280624-7v8xuicg 104 4 sequences sequence NNS cord-280624-7v8xuicg 104 5 of of IN cord-280624-7v8xuicg 104 6 the the DT cord-280624-7v8xuicg 104 7 ORF-4b ORF-4b NNP cord-280624-7v8xuicg 104 8 gene gene NN cord-280624-7v8xuicg 104 9 ( ( -LRB- cord-280624-7v8xuicg 104 10 Figure figure NN cord-280624-7v8xuicg 104 11 4 4 CD cord-280624-7v8xuicg 104 12 revealed reveal VBD cord-280624-7v8xuicg 104 13 that that IN cord-280624-7v8xuicg 104 14 all all DT cord-280624-7v8xuicg 104 15 models model NNS cord-280624-7v8xuicg 104 16 of of IN cord-280624-7v8xuicg 104 17 the the DT cord-280624-7v8xuicg 104 18 defective defective JJ cord-280624-7v8xuicg 104 19 gene gene NN cord-280624-7v8xuicg 104 20 ORF4b orf4b NN cord-280624-7v8xuicg 104 21 and and CC cord-280624-7v8xuicg 104 22 the the DT cord-280624-7v8xuicg 104 23 wild wild JJ cord-280624-7v8xuicg 104 24 type type NN cord-280624-7v8xuicg 104 25 gene gene NN cord-280624-7v8xuicg 104 26 ORF4b orf4b NN cord-280624-7v8xuicg 104 27 could could MD cord-280624-7v8xuicg 104 28 produce produce VB cord-280624-7v8xuicg 104 29 an an DT cord-280624-7v8xuicg 104 30 identical identical JJ cord-280624-7v8xuicg 104 31 potential potential JJ cord-280624-7v8xuicg 104 32 ORF ORF NNP cord-280624-7v8xuicg 104 33 of of IN cord-280624-7v8xuicg 104 34 90 90 CD cord-280624-7v8xuicg 104 35 A.A. A.A. NNP cord-280624-7v8xuicg 104 36 in in IN cord-280624-7v8xuicg 104 37 length length NN cord-280624-7v8xuicg 104 38 . . . cord-280624-7v8xuicg 105 1 We -PRON- PRP cord-280624-7v8xuicg 105 2 analyzed analyze VBD cord-280624-7v8xuicg 105 3 569 569 CD cord-280624-7v8xuicg 105 4 MERS MERS NNP cord-280624-7v8xuicg 105 5 - - HYPH cord-280624-7v8xuicg 105 6 CoV cov NN cord-280624-7v8xuicg 105 7 sequences sequence NNS cord-280624-7v8xuicg 105 8 of of IN cord-280624-7v8xuicg 105 9 ORF5 ORF5 NNP cord-280624-7v8xuicg 105 10 ( ( -LRB- cord-280624-7v8xuicg 105 11 Table Table NNP cord-280624-7v8xuicg 105 12 S1 S1 NNP cord-280624-7v8xuicg 105 13 ) ) -RRB- cord-280624-7v8xuicg 105 14 . . . cord-280624-7v8xuicg 106 1 The the DT cord-280624-7v8xuicg 106 2 fulllength fulllength NN cord-280624-7v8xuicg 106 3 of of IN cord-280624-7v8xuicg 106 4 gene gene NN cord-280624-7v8xuicg 106 5 ORF5 ORF5 NNP cord-280624-7v8xuicg 106 6 is be VBZ cord-280624-7v8xuicg 106 7 675 675 CD cord-280624-7v8xuicg 106 8 nt nt RB cord-280624-7v8xuicg 106 9 , , , cord-280624-7v8xuicg 106 10 which which WDT cord-280624-7v8xuicg 106 11 encodes encode VBZ cord-280624-7v8xuicg 106 12 a a DT cord-280624-7v8xuicg 106 13 protein protein NN cord-280624-7v8xuicg 106 14 of of IN cord-280624-7v8xuicg 106 15 224 224 CD cord-280624-7v8xuicg 106 16 AA AA NNP cord-280624-7v8xuicg 106 17 in in IN cord-280624-7v8xuicg 106 18 length length NN cord-280624-7v8xuicg 106 19 . . . cord-280624-7v8xuicg 107 1 We -PRON- PRP cord-280624-7v8xuicg 107 2 found find VBD cord-280624-7v8xuicg 107 3 two two CD cord-280624-7v8xuicg 107 4 strains strain NNS cord-280624-7v8xuicg 107 5 encoding encode VBG cord-280624-7v8xuicg 107 6 a a DT cord-280624-7v8xuicg 107 7 truncated truncated JJ cord-280624-7v8xuicg 107 8 ORF5 ORF5 NNP cord-280624-7v8xuicg 107 9 protein protein NN cord-280624-7v8xuicg 107 10 due due IN cord-280624-7v8xuicg 107 11 to to IN cord-280624-7v8xuicg 107 12 deletions deletion NNS cord-280624-7v8xuicg 107 13 causing cause VBG cord-280624-7v8xuicg 107 14 a a DT cord-280624-7v8xuicg 107 15 frameshift frameshift NN cord-280624-7v8xuicg 107 16 and and CC cord-280624-7v8xuicg 107 17 stop stop VB cord-280624-7v8xuicg 107 18 codon codon NN cord-280624-7v8xuicg 107 19 ( ( -LRB- cord-280624-7v8xuicg 107 20 ( ( -LRB- cord-280624-7v8xuicg 107 21 Figure figure NN cord-280624-7v8xuicg 107 22 2 2 CD cord-280624-7v8xuicg 107 23 and and CC cord-280624-7v8xuicg 107 24 Figure figure NN cord-280624-7v8xuicg 107 25 S4 S4 NNP cord-280624-7v8xuicg 107 26 ) ) -RRB- cord-280624-7v8xuicg 107 27 . . . cord-280624-7v8xuicg 108 1 We -PRON- PRP cord-280624-7v8xuicg 108 2 analyzed analyze VBD cord-280624-7v8xuicg 108 3 579 579 CD cord-280624-7v8xuicg 108 4 sequences sequence NNS cord-280624-7v8xuicg 108 5 of of IN cord-280624-7v8xuicg 108 6 E e NN cord-280624-7v8xuicg 108 7 gene gene NN cord-280624-7v8xuicg 108 8 and and CC cord-280624-7v8xuicg 108 9 575 575 CD cord-280624-7v8xuicg 108 10 sequences sequence NNS cord-280624-7v8xuicg 108 11 of of IN cord-280624-7v8xuicg 108 12 M M NNP cord-280624-7v8xuicg 108 13 gene gene NN cord-280624-7v8xuicg 108 14 ( ( -LRB- cord-280624-7v8xuicg 108 15 Table Table NNP cord-280624-7v8xuicg 108 16 S1 S1 NNP cord-280624-7v8xuicg 108 17 ) ) -RRB- cord-280624-7v8xuicg 108 18 . . . cord-280624-7v8xuicg 109 1 The the DT cord-280624-7v8xuicg 109 2 lengths length NNS cord-280624-7v8xuicg 109 3 for for IN cord-280624-7v8xuicg 109 4 E e NN cord-280624-7v8xuicg 109 5 protein protein NN cord-280624-7v8xuicg 109 6 and and CC cord-280624-7v8xuicg 109 7 M M NNP cord-280624-7v8xuicg 109 8 protein protein NN cord-280624-7v8xuicg 109 9 are be VBP cord-280624-7v8xuicg 109 10 82-A.A. 82-a.a. CD cord-280624-7v8xuicg 109 11 and and CC cord-280624-7v8xuicg 109 12 219-A.A. 219-a.a. CD cord-280624-7v8xuicg 109 13 , , , cord-280624-7v8xuicg 109 14 respectively respectively RB cord-280624-7v8xuicg 109 15 . . . cord-280624-7v8xuicg 110 1 Most Most JJS cord-280624-7v8xuicg 110 2 of of IN cord-280624-7v8xuicg 110 3 the the DT cord-280624-7v8xuicg 110 4 E e NN cord-280624-7v8xuicg 110 5 and and CC cord-280624-7v8xuicg 110 6 M M NNP cord-280624-7v8xuicg 110 7 gene gene NN cord-280624-7v8xuicg 110 8 sequences sequence NNS cord-280624-7v8xuicg 110 9 were be VBD cord-280624-7v8xuicg 110 10 quite quite RB cord-280624-7v8xuicg 110 11 conserved conserved JJ cord-280624-7v8xuicg 110 12 and and CC cord-280624-7v8xuicg 110 13 had have VBD cord-280624-7v8xuicg 110 14 no no DT cord-280624-7v8xuicg 110 15 significant significant JJ cord-280624-7v8xuicg 110 16 observation observation NN cord-280624-7v8xuicg 110 17 either either CC cord-280624-7v8xuicg 110 18 at at IN cord-280624-7v8xuicg 110 19 the the DT cord-280624-7v8xuicg 110 20 nucleotide nucleotide JJ cord-280624-7v8xuicg 110 21 or or CC cord-280624-7v8xuicg 110 22 amino amino NN cord-280624-7v8xuicg 110 23 acid acid NN cord-280624-7v8xuicg 110 24 level level NN cord-280624-7v8xuicg 110 25 . . . cord-280624-7v8xuicg 111 1 However however RB cord-280624-7v8xuicg 111 2 , , , cord-280624-7v8xuicg 111 3 we -PRON- PRP cord-280624-7v8xuicg 111 4 considered consider VBD cord-280624-7v8xuicg 111 5 observed observed JJ cord-280624-7v8xuicg 111 6 variants variant NNS cord-280624-7v8xuicg 111 7 not not RB cord-280624-7v8xuicg 111 8 significant significant JJ cord-280624-7v8xuicg 111 9 as as IN cord-280624-7v8xuicg 111 10 they -PRON- PRP cord-280624-7v8xuicg 111 11 either either CC cord-280624-7v8xuicg 111 12 existed exist VBD cord-280624-7v8xuicg 111 13 in in IN cord-280624-7v8xuicg 111 14 only only RB cord-280624-7v8xuicg 111 15 one one CD cord-280624-7v8xuicg 111 16 sample sample NN cord-280624-7v8xuicg 111 17 or or CC cord-280624-7v8xuicg 111 18 in in IN cord-280624-7v8xuicg 111 19 sequences sequence NNS cord-280624-7v8xuicg 111 20 generated generate VBN cord-280624-7v8xuicg 111 21 by by IN cord-280624-7v8xuicg 111 22 the the DT cord-280624-7v8xuicg 111 23 same same JJ cord-280624-7v8xuicg 111 24 group group NN cord-280624-7v8xuicg 111 25 . . . cord-280624-7v8xuicg 112 1 The the DT cord-280624-7v8xuicg 112 2 number number NN cord-280624-7v8xuicg 112 3 of of IN cord-280624-7v8xuicg 112 4 retrieved retrieve VBN cord-280624-7v8xuicg 112 5 and and CC cord-280624-7v8xuicg 112 6 analyzed analyze VBD cord-280624-7v8xuicg 112 7 sequences sequence NNS cord-280624-7v8xuicg 112 8 of of IN cord-280624-7v8xuicg 112 9 N n CD cord-280624-7v8xuicg 112 10 gene gene NN cord-280624-7v8xuicg 112 11 was be VBD cord-280624-7v8xuicg 112 12 565 565 CD cord-280624-7v8xuicg 113 1 ( ( -LRB- cord-280624-7v8xuicg 113 2 Table Table NNP cord-280624-7v8xuicg 113 3 S1 S1 NNP cord-280624-7v8xuicg 113 4 ) ) -RRB- cord-280624-7v8xuicg 113 5 . . . cord-280624-7v8xuicg 114 1 The the DT cord-280624-7v8xuicg 114 2 full full JJ cord-280624-7v8xuicg 114 3 - - HYPH cord-280624-7v8xuicg 114 4 length length NN cord-280624-7v8xuicg 114 5 of of IN cord-280624-7v8xuicg 114 6 gene gene NN cord-280624-7v8xuicg 114 7 N n CD cord-280624-7v8xuicg 114 8 is be VBZ cord-280624-7v8xuicg 114 9 1242 1242 CD cord-280624-7v8xuicg 114 10 nt nt RB cord-280624-7v8xuicg 114 11 , , , cord-280624-7v8xuicg 114 12 which which WDT cord-280624-7v8xuicg 114 13 encodes encode VBZ cord-280624-7v8xuicg 114 14 a a DT cord-280624-7v8xuicg 114 15 Table Table NNP cord-280624-7v8xuicg 114 16 3 3 CD cord-280624-7v8xuicg 114 17 ) ) -RRB- cord-280624-7v8xuicg 114 18 . . . cord-280624-7v8xuicg 115 1 We -PRON- PRP cord-280624-7v8xuicg 115 2 analyzed analyze VBD cord-280624-7v8xuicg 115 3 598 598 CD cord-280624-7v8xuicg 115 4 sequences sequence NNS cord-280624-7v8xuicg 115 5 of of IN cord-280624-7v8xuicg 115 6 gene gene NN cord-280624-7v8xuicg 115 7 ORF-8b ORF-8b NNP cord-280624-7v8xuicg 115 8 ( ( -LRB- cord-280624-7v8xuicg 115 9 Table Table NNP cord-280624-7v8xuicg 115 10 S1 S1 NNP cord-280624-7v8xuicg 115 11 ) ) -RRB- cord-280624-7v8xuicg 115 12 . . . cord-280624-7v8xuicg 116 1 The the DT cord-280624-7v8xuicg 116 2 fulllength fulllength NN cord-280624-7v8xuicg 116 3 of of IN cord-280624-7v8xuicg 116 4 the the DT cord-280624-7v8xuicg 116 5 wild wild JJ cord-280624-7v8xuicg 116 6 type type NN cord-280624-7v8xuicg 116 7 gene gene NN cord-280624-7v8xuicg 116 8 ORF8 ORF8 NNP cord-280624-7v8xuicg 116 9 is be VBZ cord-280624-7v8xuicg 116 10 339 339 CD cord-280624-7v8xuicg 116 11 nt nt NN cord-280624-7v8xuicg 116 12 , , , cord-280624-7v8xuicg 116 13 which which WDT cord-280624-7v8xuicg 116 14 encodes encode VBZ cord-280624-7v8xuicg 116 15 a a DT cord-280624-7v8xuicg 116 16 protein protein NN cord-280624-7v8xuicg 116 17 of of IN cord-280624-7v8xuicg 116 18 112 112 CD cord-280624-7v8xuicg 116 19 AA AA NNP cord-280624-7v8xuicg 116 20 in in IN cord-280624-7v8xuicg 116 21 length length NN cord-280624-7v8xuicg 116 22 . . . cord-280624-7v8xuicg 117 1 This this DT cord-280624-7v8xuicg 117 2 ORF ORF NNP cord-280624-7v8xuicg 117 3 is be VBZ cord-280624-7v8xuicg 117 4 located locate VBN cord-280624-7v8xuicg 117 5 within within IN cord-280624-7v8xuicg 117 6 the the DT cord-280624-7v8xuicg 117 7 N n CD cord-280624-7v8xuicg 117 8 gene gene NN cord-280624-7v8xuicg 117 9 ( ( -LRB- cord-280624-7v8xuicg 117 10 from from IN cord-280624-7v8xuicg 117 11 28 28 CD cord-280624-7v8xuicg 117 12 762 762 CD cord-280624-7v8xuicg 117 13 to to IN cord-280624-7v8xuicg 117 14 29 29 CD cord-280624-7v8xuicg 117 15 100 100 CD cord-280624-7v8xuicg 117 16 of of IN cord-280624-7v8xuicg 117 17 the the DT cord-280624-7v8xuicg 117 18 JX869059 JX869059 NNP cord-280624-7v8xuicg 117 19 genome genome NN cord-280624-7v8xuicg 117 20 sequencing sequencing NN cord-280624-7v8xuicg 117 21 ; ; : cord-280624-7v8xuicg 117 22 Figure figure NN cord-280624-7v8xuicg 117 23 1 1 CD cord-280624-7v8xuicg 117 24 ) ) -RRB- cord-280624-7v8xuicg 117 25 . . . cord-280624-7v8xuicg 118 1 ( ( -LRB- cord-280624-7v8xuicg 118 2 Table Table NNP cord-280624-7v8xuicg 118 3 S1 S1 NNP cord-280624-7v8xuicg 118 4 ) ) -RRB- cord-280624-7v8xuicg 118 5 . . . cord-280624-7v8xuicg 119 1 On on IN cord-280624-7v8xuicg 119 2 the the DT cord-280624-7v8xuicg 119 3 other other JJ cord-280624-7v8xuicg 119 4 hand hand NN cord-280624-7v8xuicg 119 5 , , , cord-280624-7v8xuicg 119 6 13 13 CD cord-280624-7v8xuicg 119 7 strains strain NNS cord-280624-7v8xuicg 119 8 have have VBP cord-280624-7v8xuicg 119 9 truncated truncate VBN cord-280624-7v8xuicg 119 10 ORF8 orf8 JJ cord-280624-7v8xuicg 119 11 protein protein NN cord-280624-7v8xuicg 119 12 ( ( -LRB- cord-280624-7v8xuicg 119 13 34-AA 34-aa CD cord-280624-7v8xuicg 119 14 shorter short JJR cord-280624-7v8xuicg 119 15 than than IN cord-280624-7v8xuicg 119 16 the the DT cord-280624-7v8xuicg 119 17 wild wild JJ cord-280624-7v8xuicg 119 18 type type NN cord-280624-7v8xuicg 119 19 ) ) -RRB- cord-280624-7v8xuicg 119 20 due due IN cord-280624-7v8xuicg 119 21 to to IN cord-280624-7v8xuicg 119 22 a a DT cord-280624-7v8xuicg 119 23 mutation mutation NN cord-280624-7v8xuicg 119 24 at at IN cord-280624-7v8xuicg 119 25 position position NN cord-280624-7v8xuicg 119 26 28 28 CD cord-280624-7v8xuicg 119 27 996 996 CD cord-280624-7v8xuicg 119 28 of of IN cord-280624-7v8xuicg 119 29 JX869059 JX869059 NNP cord-280624-7v8xuicg 119 30 , , , cord-280624-7v8xuicg 119 31 changing change VBG cord-280624-7v8xuicg 119 32 TCA TCA NNP cord-280624-7v8xuicg 119 33 to to IN cord-280624-7v8xuicg 119 34 a a DT cord-280624-7v8xuicg 119 35 TGA TGA NNP cord-280624-7v8xuicg 119 36 ( ( -LRB- cord-280624-7v8xuicg 119 37 stop stop VB cord-280624-7v8xuicg 119 38 codon codon NN cord-280624-7v8xuicg 119 39 ) ) -RRB- cord-280624-7v8xuicg 119 40 . . . cord-280624-7v8xuicg 120 1 One one CD cord-280624-7v8xuicg 120 2 of of IN cord-280624-7v8xuicg 120 3 these these DT cord-280624-7v8xuicg 120 4 sequences sequence NNS cord-280624-7v8xuicg 120 5 was be VBD cord-280624-7v8xuicg 120 6 isolated isolate VBN cord-280624-7v8xuicg 120 7 from from IN cord-280624-7v8xuicg 120 8 a a DT cord-280624-7v8xuicg 120 9 human human NN cord-280624-7v8xuicg 120 10 in in IN cord-280624-7v8xuicg 120 11 Qatar Qatar NNP cord-280624-7v8xuicg 120 12 during during IN cord-280624-7v8xuicg 120 13 2013 2013 CD cord-280624-7v8xuicg 120 14 while while IN cord-280624-7v8xuicg 120 15 the the DT cord-280624-7v8xuicg 120 16 others other NNS cord-280624-7v8xuicg 120 17 were be VBD cord-280624-7v8xuicg 120 18 of of IN cord-280624-7v8xuicg 120 19 human human JJ cord-280624-7v8xuicg 120 20 origin origin NN cord-280624-7v8xuicg 120 21 from from IN cord-280624-7v8xuicg 120 22 KSA KSA NNP cord-280624-7v8xuicg 120 23 in in IN cord-280624-7v8xuicg 120 24 2014 2014 CD cord-280624-7v8xuicg 120 25 ( ( -LRB- cord-280624-7v8xuicg 120 26 one one CD cord-280624-7v8xuicg 120 27 of of IN cord-280624-7v8xuicg 120 28 them -PRON- PRP cord-280624-7v8xuicg 120 29 was be VBD cord-280624-7v8xuicg 120 30 sequenced sequence VBN cord-280624-7v8xuicg 120 31 in in IN cord-280624-7v8xuicg 120 32 Indiana Indiana NNP cord-280624-7v8xuicg 120 33 - - , cord-280624-7v8xuicg 120 34 KJ813439 KJ813439 NNP cord-280624-7v8xuicg 120 35 ; ; : cord-280624-7v8xuicg 120 36 Table Table NNP cord-280624-7v8xuicg 120 37 S1 S1 NNP cord-280624-7v8xuicg 120 38 ) ) -RRB- cord-280624-7v8xuicg 120 39 . . . cord-280624-7v8xuicg 121 1 All all DT cord-280624-7v8xuicg 121 2 studied study VBD cord-280624-7v8xuicg 121 3 African african JJ cord-280624-7v8xuicg 121 4 camels camel NNS cord-280624-7v8xuicg 121 5 ( ( -LRB- cord-280624-7v8xuicg 121 6 25 25 CD cord-280624-7v8xuicg 121 7 samples sample NNS cord-280624-7v8xuicg 121 8 _SP cord-280624-7v8xuicg 121 9 MERS MERS NNP cord-280624-7v8xuicg 121 10 - - HYPH cord-280624-7v8xuicg 121 11 CoV CoV NNP cord-280624-7v8xuicg 121 12 isolated isolate VBN cord-280624-7v8xuicg 121 13 from from IN cord-280624-7v8xuicg 121 14 African african JJ cord-280624-7v8xuicg 121 15 camels camel NNS cord-280624-7v8xuicg 121 16 is be VBZ cord-280624-7v8xuicg 121 17 shown show VBN cord-280624-7v8xuicg 121 18 to to TO cord-280624-7v8xuicg 121 19 be be VB cord-280624-7v8xuicg 121 20 phylogenetically phylogenetically RB cord-280624-7v8xuicg 121 21 distinct distinct JJ cord-280624-7v8xuicg 121 22 from from IN cord-280624-7v8xuicg 121 23 those those DT cord-280624-7v8xuicg 121 24 circulating circulate VBG cord-280624-7v8xuicg 121 25 in in IN cord-280624-7v8xuicg 121 26 the the DT cord-280624-7v8xuicg 121 27 Arabian Arabian NNP cord-280624-7v8xuicg 121 28 Peninsula Peninsula NNP cord-280624-7v8xuicg 121 29 . . . cord-280624-7v8xuicg 122 1 13 13 CD cord-280624-7v8xuicg 122 2 , , , cord-280624-7v8xuicg 122 3 26 26 CD cord-280624-7v8xuicg 122 4 , , , cord-280624-7v8xuicg 122 5 27 27 CD cord-280624-7v8xuicg 123 1 In in IN cord-280624-7v8xuicg 123 2 this this DT cord-280624-7v8xuicg 123 3 study study NN cord-280624-7v8xuicg 123 4 , , , cord-280624-7v8xuicg 123 5 we -PRON- PRP cord-280624-7v8xuicg 123 6 showed show VBD cord-280624-7v8xuicg 123 7 that that IN cord-280624-7v8xuicg 123 8 the the DT cord-280624-7v8xuicg 123 9 cluster cluster NN cord-280624-7v8xuicg 123 10 of of IN cord-280624-7v8xuicg 123 11 MERS MERS NNP cord-280624-7v8xuicg 123 12 - - HYPH cord-280624-7v8xuicg 123 13 CoV cov NN cord-280624-7v8xuicg 123 14 African african JJ cord-280624-7v8xuicg 123 15 camels camel NNS cord-280624-7v8xuicg 123 16 into into IN cord-280624-7v8xuicg 123 17 ( ( -LRB- cord-280624-7v8xuicg 123 18 Table table NN cord-280624-7v8xuicg 123 19 3 3 CD cord-280624-7v8xuicg 123 20 ) ) -RRB- cord-280624-7v8xuicg 123 21 . . . cord-280624-7v8xuicg 124 1 We -PRON- PRP cord-280624-7v8xuicg 124 2 tested test VBD cord-280624-7v8xuicg 124 3 the the DT cord-280624-7v8xuicg 124 4 possibility possibility NN cord-280624-7v8xuicg 124 5 of of IN cord-280624-7v8xuicg 124 6 a a DT cord-280624-7v8xuicg 124 7 defective defective JJ cord-280624-7v8xuicg 124 8 version version NN cord-280624-7v8xuicg 124 9 of of IN cord-280624-7v8xuicg 124 10 the the DT cord-280624-7v8xuicg 124 11 ORF8 ORF8 NNP cord-280624-7v8xuicg 124 12 gene gene NN cord-280624-7v8xuicg 124 13 that that WDT cord-280624-7v8xuicg 124 14 can can MD cord-280624-7v8xuicg 124 15 produce produce VB cord-280624-7v8xuicg 124 16 ORF8 orf8 NN cord-280624-7v8xuicg 124 17 protein protein NN cord-280624-7v8xuicg 124 18 with with IN cord-280624-7v8xuicg 124 19 a a DT cord-280624-7v8xuicg 124 20 length length NN cord-280624-7v8xuicg 124 21 close close RB cord-280624-7v8xuicg 124 22 to to IN cord-280624-7v8xuicg 124 23 the the DT cord-280624-7v8xuicg 124 24 wild wild JJ cord-280624-7v8xuicg 124 25 type type NN cord-280624-7v8xuicg 124 26 by by IN cord-280624-7v8xuicg 124 27 starting start VBG cord-280624-7v8xuicg 124 28 from from IN cord-280624-7v8xuicg 124 29 different different JJ cord-280624-7v8xuicg 124 30 frames frame NNS cord-280624-7v8xuicg 124 31 rather rather RB cord-280624-7v8xuicg 124 32 than than IN cord-280624-7v8xuicg 124 33 frame-1 frame-1 NNP cord-280624-7v8xuicg 124 34 , , , cord-280624-7v8xuicg 124 35 all all DT cord-280624-7v8xuicg 124 36 possible possible JJ cord-280624-7v8xuicg 124 37 ORFs orf NNS cord-280624-7v8xuicg 124 38 were be VBD cord-280624-7v8xuicg 124 39 tested test VBN cord-280624-7v8xuicg 124 40 . . . cord-280624-7v8xuicg 125 1 There there EX cord-280624-7v8xuicg 125 2 was be VBD cord-280624-7v8xuicg 125 3 no no DT cord-280624-7v8xuicg 125 4 defective defective JJ cord-280624-7v8xuicg 125 5 form form NN cord-280624-7v8xuicg 125 6 of of IN cord-280624-7v8xuicg 125 7 gene gene NN cord-280624-7v8xuicg 125 8 ORF8 ORF8 NNP cord-280624-7v8xuicg 125 9 that that WDT cord-280624-7v8xuicg 125 10 produced produce VBD cord-280624-7v8xuicg 125 11 ORF8 orf8 JJ cord-280624-7v8xuicg 125 12 protein protein NN cord-280624-7v8xuicg 125 13 with with IN cord-280624-7v8xuicg 125 14 a a DT cord-280624-7v8xuicg 125 15 length length NN cord-280624-7v8xuicg 125 16 close close RB cord-280624-7v8xuicg 125 17 to to IN cord-280624-7v8xuicg 125 18 the the DT cord-280624-7v8xuicg 125 19 wild wild JJ cord-280624-7v8xuicg 125 20 type type NN cord-280624-7v8xuicg 125 21 ( ( -LRB- cord-280624-7v8xuicg 125 22 Figure figure NN cord-280624-7v8xuicg 125 23 S6 S6 NNP cord-280624-7v8xuicg 125 24 ) ) -RRB- cord-280624-7v8xuicg 125 25 . . . cord-280624-7v8xuicg 126 1 However however RB cord-280624-7v8xuicg 126 2 , , , cord-280624-7v8xuicg 126 3 the the DT cord-280624-7v8xuicg 126 4 biological biological JJ cord-280624-7v8xuicg 126 5 consequence consequence NN cord-280624-7v8xuicg 126 6 behind behind IN cord-280624-7v8xuicg 126 7 the the DT cord-280624-7v8xuicg 126 8 variation variation NN cord-280624-7v8xuicg 126 9 of of IN cord-280624-7v8xuicg 126 10 ORF8 orf8 JJ cord-280624-7v8xuicg 126 11 protein protein NN cord-280624-7v8xuicg 126 12 length length NN cord-280624-7v8xuicg 126 13 is be VBZ cord-280624-7v8xuicg 126 14 still still RB cord-280624-7v8xuicg 126 15 unknown unknown JJ cord-280624-7v8xuicg 126 16 . . . cord-280624-7v8xuicg 127 1 Comparative comparative JJ cord-280624-7v8xuicg 127 2 genome genome NN cord-280624-7v8xuicg 127 3 sequence sequence NN cord-280624-7v8xuicg 127 4 analysis analysis NN cord-280624-7v8xuicg 127 5 of of IN cord-280624-7v8xuicg 127 6 the the DT cord-280624-7v8xuicg 127 7 MERS MERS NNP cord-280624-7v8xuicg 127 8 - - HYPH cord-280624-7v8xuicg 127 9 CoV CoV NNP cord-280624-7v8xuicg 127 10 of of IN cord-280624-7v8xuicg 127 11 both both DT cord-280624-7v8xuicg 127 12 dromedary dromedary NN cord-280624-7v8xuicg 127 13 camels camel NNS cord-280624-7v8xuicg 127 14 and and CC cord-280624-7v8xuicg 127 15 human human JJ cord-280624-7v8xuicg 127 16 origins origin NNS cord-280624-7v8xuicg 127 17 revealed reveal VBD cord-280624-7v8xuicg 127 18 significant significant JJ cord-280624-7v8xuicg 127 19 evidence evidence NN cord-280624-7v8xuicg 127 20 for for IN cord-280624-7v8xuicg 127 21 potential potential JJ cord-280624-7v8xuicg 127 22 barcoding barcoding NN cord-280624-7v8xuicg 127 23 of of IN cord-280624-7v8xuicg 127 24 the the DT cord-280624-7v8xuicg 127 25 African african JJ cord-280624-7v8xuicg 127 26 clades clade NNS cord-280624-7v8xuicg 127 27 based base VBN cord-280624-7v8xuicg 127 28 on on IN cord-280624-7v8xuicg 127 29 the the DT cord-280624-7v8xuicg 127 30 S S NNP cord-280624-7v8xuicg 127 31 gene gene NN cord-280624-7v8xuicg 127 32 sequences sequence NNS cord-280624-7v8xuicg 127 33 . . . cord-280624-7v8xuicg 128 1 It -PRON- PRP cord-280624-7v8xuicg 128 2 also also RB cord-280624-7v8xuicg 128 3 provided provide VBD cord-280624-7v8xuicg 128 4 evidence evidence NN cord-280624-7v8xuicg 128 5 for for IN cord-280624-7v8xuicg 128 6 the the DT cord-280624-7v8xuicg 128 7 zoonotic zoonotic JJ cord-280624-7v8xuicg 128 8 origins origin NNS cord-280624-7v8xuicg 128 9 of of IN cord-280624-7v8xuicg 128 10 the the DT cord-280624-7v8xuicg 128 11 virus virus NN cord-280624-7v8xuicg 128 12 from from IN cord-280624-7v8xuicg 128 13 dromedary dromedary NN cord-280624-7v8xuicg 128 14 camels camel NNS cord-280624-7v8xuicg 128 15 to to IN cord-280624-7v8xuicg 128 16 humans human NNS cord-280624-7v8xuicg 128 17 and and CC cord-280624-7v8xuicg 128 18 highlighted highlight VBD cord-280624-7v8xuicg 128 19 the the DT cord-280624-7v8xuicg 128 20 role role NN cord-280624-7v8xuicg 128 21 of of IN cord-280624-7v8xuicg 128 22 selection selection NN cord-280624-7v8xuicg 128 23 pressure pressure NN cord-280624-7v8xuicg 128 24 and and CC cord-280624-7v8xuicg 128 25 compensatory compensatory JJ cord-280624-7v8xuicg 128 26 mechanisms mechanism NNS cord-280624-7v8xuicg 128 27 in in IN cord-280624-7v8xuicg 128 28 virus virus NN cord-280624-7v8xuicg 128 29 genome genome NN cord-280624-7v8xuicg 128 30 evolution evolution NN cord-280624-7v8xuicg 128 31 . . . cord-280624-7v8xuicg 129 1 Isolation isolation NN cord-280624-7v8xuicg 129 2 of of IN cord-280624-7v8xuicg 129 3 a a DT cord-280624-7v8xuicg 129 4 novel novel JJ cord-280624-7v8xuicg 129 5 coronavirus coronavirus NN cord-280624-7v8xuicg 129 6 from from IN cord-280624-7v8xuicg 129 7 a a DT cord-280624-7v8xuicg 129 8 man man NN cord-280624-7v8xuicg 129 9 with with IN cord-280624-7v8xuicg 129 10 pneumonia pneumonia NN cord-280624-7v8xuicg 129 11 in in IN cord-280624-7v8xuicg 129 12 Saudi Saudi NNP cord-280624-7v8xuicg 129 13 Arabia Arabia NNP cord-280624-7v8xuicg 129 14 Ninth Ninth NNP cord-280624-7v8xuicg 129 15 Report Report NNP cord-280624-7v8xuicg 129 16 of of IN cord-280624-7v8xuicg 129 17 the the DT cord-280624-7v8xuicg 129 18 International International NNP cord-280624-7v8xuicg 129 19 Committee Committee NNP cord-280624-7v8xuicg 129 20 on on IN cord-280624-7v8xuicg 129 21 Taxonomy Taxonomy NNP cord-280624-7v8xuicg 129 22 of of IN cord-280624-7v8xuicg 129 23 Viruses Viruses NNP cord-280624-7v8xuicg 129 24 Origin Origin NNP cord-280624-7v8xuicg 129 25 and and CC cord-280624-7v8xuicg 129 26 evolution evolution NN cord-280624-7v8xuicg 129 27 of of IN cord-280624-7v8xuicg 129 28 pathogenic pathogenic JJ cord-280624-7v8xuicg 129 29 coronaviruses coronaviruse NNS cord-280624-7v8xuicg 129 30 Middle Middle NNP cord-280624-7v8xuicg 129 31 East East NNP cord-280624-7v8xuicg 129 32 respiratory respiratory JJ cord-280624-7v8xuicg 129 33 syndrome syndrome NN cord-280624-7v8xuicg 129 34 coronavirus coronavirus NN cord-280624-7v8xuicg 129 35 and and CC cord-280624-7v8xuicg 129 36 the the DT cord-280624-7v8xuicg 129 37 one one CD cord-280624-7v8xuicg 129 38 health health NN cord-280624-7v8xuicg 129 39 concept concept NN cord-280624-7v8xuicg 130 1 Genomic genomic JJ cord-280624-7v8xuicg 130 2 variance variance NN cord-280624-7v8xuicg 130 3 of of IN cord-280624-7v8xuicg 130 4 the the DT cord-280624-7v8xuicg 130 5 2019-nCoV 2019-ncov CD cord-280624-7v8xuicg 130 6 coronavirus coronavirus NN cord-280624-7v8xuicg 130 7 Full full JJ cord-280624-7v8xuicg 130 8 genome genome NN cord-280624-7v8xuicg 130 9 characterization characterization NN cord-280624-7v8xuicg 130 10 of of IN cord-280624-7v8xuicg 130 11 two two CD cord-280624-7v8xuicg 130 12 novel novel JJ cord-280624-7v8xuicg 130 13 alpha alpha NN cord-280624-7v8xuicg 130 14 - - HYPH cord-280624-7v8xuicg 130 15 coronavirus coronavirus NN cord-280624-7v8xuicg 130 16 species specie NNS cord-280624-7v8xuicg 130 17 from from IN cord-280624-7v8xuicg 130 18 Italian italian JJ cord-280624-7v8xuicg 130 19 bats bat NNS cord-280624-7v8xuicg 130 20 Full full JJ cord-280624-7v8xuicg 130 21 - - HYPH cord-280624-7v8xuicg 130 22 length length NN cord-280624-7v8xuicg 130 23 genome genome NN cord-280624-7v8xuicg 130 24 analysis analysis NN cord-280624-7v8xuicg 130 25 of of IN cord-280624-7v8xuicg 130 26 canine canine JJ cord-280624-7v8xuicg 130 27 coronavirus coronavirus NN cord-280624-7v8xuicg 130 28 type type NN cord-280624-7v8xuicg 130 29 I I NNP cord-280624-7v8xuicg 130 30 Molecular Molecular NNP cord-280624-7v8xuicg 130 31 investigation investigation NN cord-280624-7v8xuicg 130 32 of of IN cord-280624-7v8xuicg 130 33 a a DT cord-280624-7v8xuicg 130 34 fulllength fulllength NN cord-280624-7v8xuicg 130 35 genome genome NN cord-280624-7v8xuicg 130 36 of of IN cord-280624-7v8xuicg 130 37 a a DT cord-280624-7v8xuicg 130 38 Q1-like Q1-like , cord-280624-7v8xuicg 130 39 IBV IBV NNP cord-280624-7v8xuicg 130 40 strain strain NN cord-280624-7v8xuicg 130 41 isolated isolate VBN cord-280624-7v8xuicg 130 42 in in IN cord-280624-7v8xuicg 130 43 Italy Italy NNP cord-280624-7v8xuicg 130 44 in in IN cord-280624-7v8xuicg 130 45 2013 2013 CD cord-280624-7v8xuicg 131 1 A a DT cord-280624-7v8xuicg 131 2 metagenomic metagenomic FW cord-280624-7v8xuicg 131 3 viral viral JJ cord-280624-7v8xuicg 131 4 discovery discovery NN cord-280624-7v8xuicg 131 5 approach approach NN cord-280624-7v8xuicg 131 6 identifies identify VBZ cord-280624-7v8xuicg 131 7 potential potential JJ cord-280624-7v8xuicg 131 8 zoonotic zoonotic JJ cord-280624-7v8xuicg 131 9 and and CC cord-280624-7v8xuicg 131 10 novel novel JJ cord-280624-7v8xuicg 131 11 mammalian mammalian JJ cord-280624-7v8xuicg 131 12 viruses virus NNS cord-280624-7v8xuicg 131 13 in in IN cord-280624-7v8xuicg 131 14 Neoromicia Neoromicia NNP cord-280624-7v8xuicg 131 15 bats bat NNS cord-280624-7v8xuicg 131 16 within within IN cord-280624-7v8xuicg 131 17 South South NNP cord-280624-7v8xuicg 131 18 Africa Africa NNP cord-280624-7v8xuicg 131 19 Molecular Molecular NNP cord-280624-7v8xuicg 131 20 identification identification NN cord-280624-7v8xuicg 131 21 and and CC cord-280624-7v8xuicg 131 22 characterization characterization NN cord-280624-7v8xuicg 131 23 of of IN cord-280624-7v8xuicg 131 24 novel novel NN cord-280624-7v8xuicg 131 25 coronaviruses coronaviruse NNS cord-280624-7v8xuicg 131 26 infecting infect VBG cord-280624-7v8xuicg 131 27 graylag graylag NNP cord-280624-7v8xuicg 131 28 geese goose NNS cord-280624-7v8xuicg 131 29 ( ( -LRB- cord-280624-7v8xuicg 131 30 Anser Anser NNP cord-280624-7v8xuicg 131 31 anser anser NNP cord-280624-7v8xuicg 131 32 ) ) -RRB- cord-280624-7v8xuicg 131 33 , , , cord-280624-7v8xuicg 131 34 feral feral JJ cord-280624-7v8xuicg 131 35 pigeons pigeon NNS cord-280624-7v8xuicg 131 36 ( ( -LRB- cord-280624-7v8xuicg 131 37 Columbia Columbia NNP cord-280624-7v8xuicg 131 38 livia livia NNP cord-280624-7v8xuicg 131 39 ) ) -RRB- cord-280624-7v8xuicg 131 40 and and CC cord-280624-7v8xuicg 131 41 mallards mallard NNS cord-280624-7v8xuicg 131 42 Complete complete VB cord-280624-7v8xuicg 131 43 genome genome NN cord-280624-7v8xuicg 131 44 analysis analysis NN cord-280624-7v8xuicg 131 45 of of IN cord-280624-7v8xuicg 131 46 equine equine JJ cord-280624-7v8xuicg 131 47 coronavirus coronavirus NN cord-280624-7v8xuicg 131 48 isolated isolate VBN cord-280624-7v8xuicg 131 49 in in IN cord-280624-7v8xuicg 131 50 Japan Japan NNP cord-280624-7v8xuicg 131 51 Full full JJ cord-280624-7v8xuicg 131 52 - - HYPH cord-280624-7v8xuicg 131 53 length length NN cord-280624-7v8xuicg 131 54 genome genome NN cord-280624-7v8xuicg 131 55 sequences sequence NNS cord-280624-7v8xuicg 131 56 of of IN cord-280624-7v8xuicg 132 1 porcine porcine JJ cord-280624-7v8xuicg 132 2 epidemic epidemic NN cord-280624-7v8xuicg 132 3 diarrhoea diarrhoea NN cord-280624-7v8xuicg 132 4 virus virus NN cord-280624-7v8xuicg 132 5 strain strain VBP cord-280624-7v8xuicg 132 6 CV777 CV777 '' cord-280624-7v8xuicg 132 7 ; ; : cord-280624-7v8xuicg 132 8 use use NN cord-280624-7v8xuicg 132 9 of of IN cord-280624-7v8xuicg 132 10 NGS NGS NNP cord-280624-7v8xuicg 132 11 to to TO cord-280624-7v8xuicg 132 12 analyse analyse VB cord-280624-7v8xuicg 132 13 genomic genomic JJ cord-280624-7v8xuicg 132 14 and and CC cord-280624-7v8xuicg 132 15 sub sub JJ cord-280624-7v8xuicg 132 16 - - JJ cord-280624-7v8xuicg 132 17 genomic genomic JJ cord-280624-7v8xuicg 132 18 RNAs rna NNS cord-280624-7v8xuicg 132 19 MERS MERS NNP cord-280624-7v8xuicg 132 20 coronaviruses coronaviruse NNS cord-280624-7v8xuicg 132 21 from from IN cord-280624-7v8xuicg 132 22 camels camel NNS cord-280624-7v8xuicg 132 23 in in IN cord-280624-7v8xuicg 132 24 Africa Africa NNP cord-280624-7v8xuicg 132 25 exhibit exhibit NN cord-280624-7v8xuicg 132 26 region region NN cord-280624-7v8xuicg 132 27 - - HYPH cord-280624-7v8xuicg 132 28 dependent dependent JJ cord-280624-7v8xuicg 132 29 genetic genetic JJ cord-280624-7v8xuicg 132 30 diversity diversity NN cord-280624-7v8xuicg 132 31 Genomics genomic NNS cord-280624-7v8xuicg 132 32 and and CC cord-280624-7v8xuicg 132 33 zoonotic zoonotic JJ cord-280624-7v8xuicg 132 34 infections infection NNS cord-280624-7v8xuicg 132 35 : : : cord-280624-7v8xuicg 132 36 Middle Middle NNP cord-280624-7v8xuicg 132 37 East East NNP cord-280624-7v8xuicg 132 38 respiratory respiratory JJ cord-280624-7v8xuicg 132 39 syndrome syndrome NN cord-280624-7v8xuicg 132 40 Detection detection NN cord-280624-7v8xuicg 132 41 of of IN cord-280624-7v8xuicg 132 42 distinct distinct JJ cord-280624-7v8xuicg 132 43 MERS mers NN cord-280624-7v8xuicg 132 44 - - HYPH cord-280624-7v8xuicg 132 45 coronavirus coronavirus NN cord-280624-7v8xuicg 132 46 strains strain NNS cord-280624-7v8xuicg 132 47 in in IN cord-280624-7v8xuicg 132 48 dromedary dromedary NN cord-280624-7v8xuicg 132 49 camels camel NNS cord-280624-7v8xuicg 132 50 from from IN cord-280624-7v8xuicg 132 51 Kenya Kenya NNP cord-280624-7v8xuicg 132 52 Dromedary Dromedary NNP cord-280624-7v8xuicg 132 53 camels camel NNS cord-280624-7v8xuicg 132 54 and and CC cord-280624-7v8xuicg 132 55 the the DT cord-280624-7v8xuicg 132 56 transmission transmission NN cord-280624-7v8xuicg 132 57 of of IN cord-280624-7v8xuicg 132 58 Middle Middle NNP cord-280624-7v8xuicg 132 59 East East NNP cord-280624-7v8xuicg 132 60 respiratory respiratory JJ cord-280624-7v8xuicg 132 61 syndrome syndrome NN cord-280624-7v8xuicg 132 62 coronavirus coronavirus NN cord-280624-7v8xuicg 132 63 ( ( -LRB- cord-280624-7v8xuicg 132 64 MERS MERS NNP cord-280624-7v8xuicg 132 65 - - HYPH cord-280624-7v8xuicg 132 66 CoV CoV NNP cord-280624-7v8xuicg 132 67 ) ) -RRB- cord-280624-7v8xuicg 133 1 Middle Middle NNP cord-280624-7v8xuicg 133 2 East East NNP cord-280624-7v8xuicg 133 3 respiratory respiratory JJ cord-280624-7v8xuicg 133 4 syndrome syndrome NN cord-280624-7v8xuicg 133 5 coronavirus coronavirus NN cord-280624-7v8xuicg 133 6 in in IN cord-280624-7v8xuicg 133 7 bats bat NNS cord-280624-7v8xuicg 133 8 , , , cord-280624-7v8xuicg 133 9 Saudi Saudi NNP cord-280624-7v8xuicg 133 10 Arabia Arabia NNP cord-280624-7v8xuicg 133 11 Middle Middle NNP cord-280624-7v8xuicg 133 12 East East NNP cord-280624-7v8xuicg 133 13 respiratory respiratory JJ cord-280624-7v8xuicg 133 14 syndrome syndrome NN cord-280624-7v8xuicg 133 15 coronavirus coronavirus NN cord-280624-7v8xuicg 133 16 transmission transmission NN cord-280624-7v8xuicg 133 17 Spread spread NN cord-280624-7v8xuicg 133 18 , , , cord-280624-7v8xuicg 133 19 circulation circulation NN cord-280624-7v8xuicg 133 20 , , , cord-280624-7v8xuicg 133 21 and and CC cord-280624-7v8xuicg 133 22 evolution evolution NN cord-280624-7v8xuicg 133 23 of of IN cord-280624-7v8xuicg 133 24 the the DT cord-280624-7v8xuicg 133 25 Middle Middle NNP cord-280624-7v8xuicg 133 26 East East NNP cord-280624-7v8xuicg 133 27 respiratory respiratory JJ cord-280624-7v8xuicg 133 28 syndrome syndrome NN cord-280624-7v8xuicg 133 29 coronavirus coronavirus NN cord-280624-7v8xuicg 133 30 Transmission transmission NN cord-280624-7v8xuicg 133 31 and and CC cord-280624-7v8xuicg 133 32 evolution evolution NN cord-280624-7v8xuicg 133 33 of of IN cord-280624-7v8xuicg 133 34 the the DT cord-280624-7v8xuicg 133 35 Middle Middle NNP cord-280624-7v8xuicg 133 36 East East NNP cord-280624-7v8xuicg 133 37 respiratory respiratory JJ cord-280624-7v8xuicg 133 38 syndrome syndrome NN cord-280624-7v8xuicg 133 39 coronavirus coronavirus NN cord-280624-7v8xuicg 133 40 in in IN cord-280624-7v8xuicg 133 41 Saudi Saudi NNP cord-280624-7v8xuicg 133 42 Arabia Arabia NNP cord-280624-7v8xuicg 133 43 : : : cord-280624-7v8xuicg 133 44 a a DT cord-280624-7v8xuicg 133 45 descriptive descriptive JJ cord-280624-7v8xuicg 133 46 genomic genomic JJ cord-280624-7v8xuicg 133 47 study study NN cord-280624-7v8xuicg 133 48 Unique Unique NNP cord-280624-7v8xuicg 133 49 and and CC cord-280624-7v8xuicg 133 50 conserved conserve VBN cord-280624-7v8xuicg 133 51 features feature NNS cord-280624-7v8xuicg 133 52 of of IN cord-280624-7v8xuicg 133 53 genome genome NN cord-280624-7v8xuicg 133 54 and and CC cord-280624-7v8xuicg 133 55 proteome proteome NN cord-280624-7v8xuicg 133 56 of of IN cord-280624-7v8xuicg 133 57 SARS SARS NNP cord-280624-7v8xuicg 133 58 - - HYPH cord-280624-7v8xuicg 133 59 coronavirus coronavirus NN cord-280624-7v8xuicg 133 60 , , , cord-280624-7v8xuicg 133 61 an an DT cord-280624-7v8xuicg 133 62 early early JJ cord-280624-7v8xuicg 133 63 split split NN cord-280624-7v8xuicg 133 64 - - HYPH cord-280624-7v8xuicg 133 65 off off NN cord-280624-7v8xuicg 133 66 from from IN cord-280624-7v8xuicg 133 67 the the DT cord-280624-7v8xuicg 133 68 coronavirus coronavirus NN cord-280624-7v8xuicg 133 69 group group NN cord-280624-7v8xuicg 133 70 2 2 CD cord-280624-7v8xuicg 133 71 lineage lineage NN cord-280624-7v8xuicg 133 72 MEGA7 MEGA7 NNP cord-280624-7v8xuicg 133 73 : : : cord-280624-7v8xuicg 134 1 molecular molecular JJ cord-280624-7v8xuicg 134 2 evolutionary evolutionary JJ cord-280624-7v8xuicg 134 3 genetics genetics NNP cord-280624-7v8xuicg 134 4 analysis analysis NNP cord-280624-7v8xuicg 134 5 version version NN cord-280624-7v8xuicg 134 6 7.0 7.0 CD cord-280624-7v8xuicg 134 7 for for IN cord-280624-7v8xuicg 134 8 bigger big JJR cord-280624-7v8xuicg 134 9 datasets dataset NNS cord-280624-7v8xuicg 134 10 Variations variation NNS cord-280624-7v8xuicg 134 11 in in IN cord-280624-7v8xuicg 134 12 spike spike NN cord-280624-7v8xuicg 134 13 glycoprotein glycoprotein NN cord-280624-7v8xuicg 134 14 gene gene NN cord-280624-7v8xuicg 134 15 of of IN cord-280624-7v8xuicg 134 16 MERS MERS NNP cord-280624-7v8xuicg 134 17 - - HYPH cord-280624-7v8xuicg 134 18 CoV CoV NNP cord-280624-7v8xuicg 135 1 The the DT cord-280624-7v8xuicg 135 2 severe severe JJ cord-280624-7v8xuicg 135 3 acute acute JJ cord-280624-7v8xuicg 135 4 respiratory respiratory JJ cord-280624-7v8xuicg 135 5 syndrome syndrome NN cord-280624-7v8xuicg 136 1 A a DT cord-280624-7v8xuicg 136 2 novel novel JJ cord-280624-7v8xuicg 136 3 coronavirus coronavirus NN cord-280624-7v8xuicg 136 4 from from IN cord-280624-7v8xuicg 136 5 patients patient NNS cord-280624-7v8xuicg 136 6 with with IN cord-280624-7v8xuicg 136 7 pneumonia pneumonia NN cord-280624-7v8xuicg 136 8 in in IN cord-280624-7v8xuicg 136 9 China China NNP cord-280624-7v8xuicg 136 10 Middle Middle NNP cord-280624-7v8xuicg 136 11 East East NNP cord-280624-7v8xuicg 136 12 respiratory respiratory JJ cord-280624-7v8xuicg 136 13 syndrome syndrome NN cord-280624-7v8xuicg 136 14 coronavirus coronavirus NN cord-280624-7v8xuicg 136 15 ( ( -LRB- cord-280624-7v8xuicg 136 16 MERS MERS NNP cord-280624-7v8xuicg 136 17 - - HYPH cord-280624-7v8xuicg 136 18 CoV CoV NNP cord-280624-7v8xuicg 136 19 ) ) -RRB- cord-280624-7v8xuicg 136 20 in in IN cord-280624-7v8xuicg 136 21 dromedary dromedary NN cord-280624-7v8xuicg 136 22 camels camel NNS cord-280624-7v8xuicg 136 23 in in IN cord-280624-7v8xuicg 136 24 Africa Africa NNP cord-280624-7v8xuicg 136 25 and and CC cord-280624-7v8xuicg 136 26 Middle Middle NNP cord-280624-7v8xuicg 136 27 East East NNP cord-280624-7v8xuicg 137 1 Serological serological JJ cord-280624-7v8xuicg 137 2 evidence evidence NN cord-280624-7v8xuicg 137 3 of of IN cord-280624-7v8xuicg 137 4 MERS MERS NNP cord-280624-7v8xuicg 137 5 - - HYPH cord-280624-7v8xuicg 137 6 CoV CoV NNP cord-280624-7v8xuicg 137 7 and and CC cord-280624-7v8xuicg 137 8 HKU8-related HKU8-related NNP cord-280624-7v8xuicg 137 9 CoV CoV NNP cord-280624-7v8xuicg 137 10 co co NN cord-280624-7v8xuicg 137 11 - - NN cord-280624-7v8xuicg 137 12 infection infection NN cord-280624-7v8xuicg 137 13 in in IN cord-280624-7v8xuicg 137 14 Kenyan kenyan JJ cord-280624-7v8xuicg 137 15 camels camel NNS cord-280624-7v8xuicg 138 1 The the DT cord-280624-7v8xuicg 138 2 severe severe JJ cord-280624-7v8xuicg 138 3 acute acute JJ cord-280624-7v8xuicg 138 4 respiratory respiratory JJ cord-280624-7v8xuicg 138 5 syndrome syndrome NN cord-280624-7v8xuicg 138 6 coronavirus coronavirus NN cord-280624-7v8xuicg 139 1 Nucleocapsid Nucleocapsid NNP cord-280624-7v8xuicg 139 2 inhibits inhibit VBZ cord-280624-7v8xuicg 139 3 type type NN cord-280624-7v8xuicg 139 4 I -PRON- PRP cord-280624-7v8xuicg 140 1 interferon interferon NN cord-280624-7v8xuicg 140 2 production production NN cord-280624-7v8xuicg 140 3 by by IN cord-280624-7v8xuicg 140 4 interfering interfere VBG cord-280624-7v8xuicg 140 5 with with IN cord-280624-7v8xuicg 140 6 TRIM25-mediated trim25-mediated JJ cord-280624-7v8xuicg 140 7 RIG- RIG- NNP cord-280624-7v8xuicg 141 1 I -PRON- PRP cord-280624-7v8xuicg 141 2 ubiquitination ubiquitination RB cord-280624-7v8xuicg 142 1 We -PRON- PRP cord-280624-7v8xuicg 142 2 wish wish VBP cord-280624-7v8xuicg 142 3 to to TO cord-280624-7v8xuicg 142 4 thank thank VB cord-280624-7v8xuicg 142 5 the the DT cord-280624-7v8xuicg 142 6 King King NNP cord-280624-7v8xuicg 142 7 Abdul Abdul NNP cord-280624-7v8xuicg 142 8 - - HYPH cord-280624-7v8xuicg 142 9 Aziz Aziz NNP cord-280624-7v8xuicg 142 10 City City NNP cord-280624-7v8xuicg 142 11 for for IN cord-280624-7v8xuicg 142 12 Science Science NNP cord-280624-7v8xuicg 142 13 and and CC cord-280624-7v8xuicg 142 14 Technology Technology NNP cord-280624-7v8xuicg 142 15 ( ( -LRB- cord-280624-7v8xuicg 142 16 KACST KACST NNP cord-280624-7v8xuicg 142 17 ) ) -RRB- cord-280624-7v8xuicg 142 18 , , , cord-280624-7v8xuicg 142 19 Saudi Saudi NNP cord-280624-7v8xuicg 142 20 Arabia Arabia NNP cord-280624-7v8xuicg 142 21 , , , cord-280624-7v8xuicg 142 22 for for IN cord-280624-7v8xuicg 142 23 their -PRON- PRP$ cord-280624-7v8xuicg 142 24 generous generous JJ cord-280624-7v8xuicg 142 25 funding funding NN cord-280624-7v8xuicg 142 26 through through IN cord-280624-7v8xuicg 142 27 the the DT cord-280624-7v8xuicg 142 28 MERS MERS NNP cord-280624-7v8xuicg 142 29 - - HYPH cord-280624-7v8xuicg 142 30 CoV CoV NNP cord-280624-7v8xuicg 142 31 research research NN cord-280624-7v8xuicg 142 32 grant grant NN cord-280624-7v8xuicg 142 33 program program NN cord-280624-7v8xuicg 142 34 ( ( -LRB- cord-280624-7v8xuicg 142 35 number number NN cord-280624-7v8xuicg 142 36 20 20 CD cord-280624-7v8xuicg 142 37 - - HYPH cord-280624-7v8xuicg 142 38 0004 0004 CD cord-280624-7v8xuicg 142 39 ) ) -RRB- cord-280624-7v8xuicg 142 40 , , , cord-280624-7v8xuicg 142 41 which which WDT cord-280624-7v8xuicg 142 42 is be VBZ cord-280624-7v8xuicg 142 43 a a DT cord-280624-7v8xuicg 142 44 part part NN cord-280624-7v8xuicg 142 45 of of IN cord-280624-7v8xuicg 142 46 the the DT cord-280624-7v8xuicg 142 47 Targeted Targeted NNP cord-280624-7v8xuicg 142 48 Research Research NNP cord-280624-7v8xuicg 142 49 Program Program NNP cord-280624-7v8xuicg 142 50 ( ( -LRB- cord-280624-7v8xuicg 142 51 TRP TRP NNP cord-280624-7v8xuicg 142 52 ) ) -RRB- cord-280624-7v8xuicg 142 53 . . . cord-280624-7v8xuicg 143 1 The the DT cord-280624-7v8xuicg 143 2 authors author NNS cord-280624-7v8xuicg 143 3 have have VBP cord-280624-7v8xuicg 143 4 no no DT cord-280624-7v8xuicg 143 5 competing compete VBG cord-280624-7v8xuicg 143 6 interest interest NN cord-280624-7v8xuicg 143 7 . . . cord-280624-7v8xuicg 144 1 https://orcid.org/0000-0002-5986-7237 https://orcid.org/0000-0002-5986-7237 ADD cord-280624-7v8xuicg 145 1 Additional additional JJ cord-280624-7v8xuicg 145 2 supporting support VBG cord-280624-7v8xuicg 145 3 information information NN cord-280624-7v8xuicg 145 4 may may MD cord-280624-7v8xuicg 145 5 be be VB cord-280624-7v8xuicg 145 6 found find VBN cord-280624-7v8xuicg 145 7 online online RB cord-280624-7v8xuicg 145 8 in in IN cord-280624-7v8xuicg 145 9 the the DT cord-280624-7v8xuicg 145 10 Supporting support VBG cord-280624-7v8xuicg 145 11 Information information NN cord-280624-7v8xuicg 145 12 section section NN cord-280624-7v8xuicg 145 13 at at IN cord-280624-7v8xuicg 145 14 the the DT cord-280624-7v8xuicg 145 15 end end NN cord-280624-7v8xuicg 145 16 of of IN cord-280624-7v8xuicg 145 17 this this DT cord-280624-7v8xuicg 145 18 article article NN cord-280624-7v8xuicg 145 19 . . . cord-280624-7v8xuicg 145 20 _SP