id sid tid token lemma pos cord-267001-csgmc155 1 1 key key NN cord-267001-csgmc155 1 2 : : : cord-267001-csgmc155 1 3 cord-267001-csgmc155 cord-267001-csgmc155 NNP cord-267001-csgmc155 1 4 authors author NNS cord-267001-csgmc155 1 5 : : : cord-267001-csgmc155 1 6 George George NNP cord-267001-csgmc155 1 7 , , , cord-267001-csgmc155 1 8 Parakkal Parakkal NNP cord-267001-csgmc155 1 9 Jovvian Jovvian NNP cord-267001-csgmc155 1 10 ; ; : cord-267001-csgmc155 1 11 Tai Tai NNP cord-267001-csgmc155 1 12 , , , cord-267001-csgmc155 1 13 Wanbo Wanbo NNP cord-267001-csgmc155 1 14 ; ; : cord-267001-csgmc155 1 15 Du Du NNP cord-267001-csgmc155 1 16 , , , cord-267001-csgmc155 1 17 Lanying Lanying NNP cord-267001-csgmc155 1 18 ; ; : cord-267001-csgmc155 1 19 Lustigman Lustigman NNP cord-267001-csgmc155 1 20 , , , cord-267001-csgmc155 1 21 Sara Sara NNP cord-267001-csgmc155 2 1 title title NN cord-267001-csgmc155 2 2 : : : cord-267001-csgmc155 3 1 The the DT cord-267001-csgmc155 3 2 Potency Potency NNP cord-267001-csgmc155 3 3 of of IN cord-267001-csgmc155 3 4 an an DT cord-267001-csgmc155 3 5 Anti Anti NNP cord-267001-csgmc155 3 6 - - NNP cord-267001-csgmc155 3 7 MERS MERS NNP cord-267001-csgmc155 3 8 Coronavirus Coronavirus NNP cord-267001-csgmc155 3 9 Subunit Subunit NNP cord-267001-csgmc155 3 10 Vaccine Vaccine NNP cord-267001-csgmc155 3 11 Depends depend VBZ cord-267001-csgmc155 3 12 on on IN cord-267001-csgmc155 3 13 a a DT cord-267001-csgmc155 3 14 Unique unique JJ cord-267001-csgmc155 3 15 Combinatorial Combinatorial NNP cord-267001-csgmc155 3 16 Adjuvant Adjuvant NNP cord-267001-csgmc155 3 17 Formulation Formulation NNP cord-267001-csgmc155 3 18 date date NN cord-267001-csgmc155 3 19 : : : cord-267001-csgmc155 3 20 2020 2020 CD cord-267001-csgmc155 3 21 - - HYPH cord-267001-csgmc155 3 22 05 05 CD cord-267001-csgmc155 3 23 - - HYPH cord-267001-csgmc155 3 24 27 27 CD cord-267001-csgmc155 3 25 journal journal NN cord-267001-csgmc155 3 26 : : : cord-267001-csgmc155 3 27 Vaccines Vaccines NNP cord-267001-csgmc155 3 28 ( ( -LRB- cord-267001-csgmc155 3 29 Basel Basel NNP cord-267001-csgmc155 3 30 ) ) -RRB- cord-267001-csgmc155 3 31 DOI DOI NNP cord-267001-csgmc155 3 32 : : : cord-267001-csgmc155 4 1 10.3390 10.3390 CD cord-267001-csgmc155 4 2 / / SYM cord-267001-csgmc155 4 3 vaccines8020251 vaccines8020251 NN cord-267001-csgmc155 5 1 sha sha NNP cord-267001-csgmc155 5 2 : : : cord-267001-csgmc155 6 1 64e435a73d7c656a95403aef740b9fa6c377be3c 64e435a73d7c656a95403aef740b9fa6c377be3c RB cord-267001-csgmc155 6 2 doc_id doc_id CD cord-267001-csgmc155 7 1 : : : cord-267001-csgmc155 7 2 267001 267001 CD cord-267001-csgmc155 7 3 cord_uid cord_uid NNS cord-267001-csgmc155 7 4 : : : cord-267001-csgmc155 8 1 csgmc155 csgmc155 NNP cord-267001-csgmc155 8 2 Vaccination Vaccination NNP cord-267001-csgmc155 8 3 is be VBZ cord-267001-csgmc155 8 4 one one CD cord-267001-csgmc155 8 5 of of IN cord-267001-csgmc155 8 6 the the DT cord-267001-csgmc155 8 7 most most RBS cord-267001-csgmc155 8 8 successful successful JJ cord-267001-csgmc155 8 9 strategies strategy NNS cord-267001-csgmc155 8 10 to to TO cord-267001-csgmc155 8 11 prevent prevent VB cord-267001-csgmc155 8 12 human human JJ cord-267001-csgmc155 8 13 infectious infectious JJ cord-267001-csgmc155 8 14 diseases disease NNS cord-267001-csgmc155 8 15 . . . cord-267001-csgmc155 9 1 Combinatorial combinatorial JJ cord-267001-csgmc155 9 2 adjuvants adjuvant NNS cord-267001-csgmc155 9 3 have have VBP cord-267001-csgmc155 9 4 gained gain VBN cord-267001-csgmc155 9 5 increasing increase VBG cord-267001-csgmc155 9 6 interest interest NN cord-267001-csgmc155 9 7 as as IN cord-267001-csgmc155 9 8 they -PRON- PRP cord-267001-csgmc155 9 9 can can MD cord-267001-csgmc155 9 10 stimulate stimulate VB cord-267001-csgmc155 9 11 multiple multiple JJ cord-267001-csgmc155 9 12 immune immune JJ cord-267001-csgmc155 9 13 pathways pathway NNS cord-267001-csgmc155 9 14 and and CC cord-267001-csgmc155 9 15 enhance enhance VB cord-267001-csgmc155 9 16 the the DT cord-267001-csgmc155 9 17 vaccine vaccine NN cord-267001-csgmc155 9 18 efficacy efficacy NN cord-267001-csgmc155 9 19 of of IN cord-267001-csgmc155 9 20 subunit subunit NN cord-267001-csgmc155 9 21 vaccines vaccine NNS cord-267001-csgmc155 9 22 . . . cord-267001-csgmc155 10 1 We -PRON- PRP cord-267001-csgmc155 10 2 investigated investigate VBD cord-267001-csgmc155 10 3 the the DT cord-267001-csgmc155 10 4 adjuvanticity adjuvanticity NN cord-267001-csgmc155 10 5 of of IN cord-267001-csgmc155 10 6 Aluminum aluminum NN cord-267001-csgmc155 10 7 ( ( -LRB- cord-267001-csgmc155 10 8 alum alum NN cord-267001-csgmc155 10 9 ) ) -RRB- cord-267001-csgmc155 10 10 in in IN cord-267001-csgmc155 10 11 combination combination NN cord-267001-csgmc155 10 12 with with IN cord-267001-csgmc155 10 13 rASP-1 rASP-1 NNP cord-267001-csgmc155 10 14 , , , cord-267001-csgmc155 10 15 a a DT cord-267001-csgmc155 10 16 protein protein NN cord-267001-csgmc155 10 17 adjuvant adjuvant NN cord-267001-csgmc155 10 18 , , , cord-267001-csgmc155 10 19 using use VBG cord-267001-csgmc155 10 20 the the DT cord-267001-csgmc155 10 21 Middle Middle NNP cord-267001-csgmc155 10 22 East East NNP cord-267001-csgmc155 10 23 respiratory respiratory JJ cord-267001-csgmc155 10 24 syndrome syndrome NN cord-267001-csgmc155 10 25 coronavirus coronavirus NN cord-267001-csgmc155 10 26 MERS MERS NNP cord-267001-csgmc155 10 27 - - HYPH cord-267001-csgmc155 10 28 CoV CoV NNP cord-267001-csgmc155 10 29 receptor receptor NN cord-267001-csgmc155 10 30 - - HYPH cord-267001-csgmc155 10 31 binding bind VBG cord-267001-csgmc155 10 32 - - HYPH cord-267001-csgmc155 10 33 domain domain NN cord-267001-csgmc155 10 34 ( ( -LRB- cord-267001-csgmc155 10 35 RBD RBD NNP cord-267001-csgmc155 10 36 ) ) -RRB- cord-267001-csgmc155 10 37 vaccine vaccine NN cord-267001-csgmc155 10 38 antigen antigen NN cord-267001-csgmc155 10 39 . . . cord-267001-csgmc155 11 1 A a DT cord-267001-csgmc155 11 2 highly highly RB cord-267001-csgmc155 11 3 enhanced enhance VBN cord-267001-csgmc155 11 4 anti anti JJ cord-267001-csgmc155 11 5 - - JJ cord-267001-csgmc155 11 6 MERS mers JJ cord-267001-csgmc155 11 7 - - HYPH cord-267001-csgmc155 11 8 CoV CoV NNP cord-267001-csgmc155 11 9 neutralizing neutralize VBG cord-267001-csgmc155 11 10 antibody antibody NN cord-267001-csgmc155 11 11 response response NN cord-267001-csgmc155 11 12 was be VBD cord-267001-csgmc155 11 13 induced induce VBN cord-267001-csgmc155 11 14 when when WRB cord-267001-csgmc155 11 15 mice mouse NNS cord-267001-csgmc155 11 16 were be VBD cord-267001-csgmc155 11 17 immunized immunize VBN cord-267001-csgmc155 11 18 with with IN cord-267001-csgmc155 11 19 rASP-1 rASP-1 NNP cord-267001-csgmc155 11 20 and and CC cord-267001-csgmc155 11 21 the the DT cord-267001-csgmc155 11 22 alum alum NN cord-267001-csgmc155 11 23 - - HYPH cord-267001-csgmc155 11 24 adjuvanted adjuvante VBN cord-267001-csgmc155 11 25 RBD RBD NNP cord-267001-csgmc155 11 26 vaccine vaccine NN cord-267001-csgmc155 11 27 in in IN cord-267001-csgmc155 11 28 two two CD cord-267001-csgmc155 11 29 separate separate JJ cord-267001-csgmc155 11 30 injection injection NN cord-267001-csgmc155 11 31 sites site NNS cord-267001-csgmc155 11 32 as as IN cord-267001-csgmc155 11 33 compared compare VBN cord-267001-csgmc155 11 34 to to IN cord-267001-csgmc155 11 35 mice mouse NNS cord-267001-csgmc155 11 36 immunized immunize VBN cord-267001-csgmc155 11 37 with with IN cord-267001-csgmc155 11 38 RBD RBD NNP cord-267001-csgmc155 11 39 + + CC cord-267001-csgmc155 12 1 rASP-1 rasp-1 LS cord-267001-csgmc155 12 2 + + CC cord-267001-csgmc155 12 3 alum alum NN cord-267001-csgmc155 12 4 formulated formulate VBD cord-267001-csgmc155 12 5 into into IN cord-267001-csgmc155 12 6 a a DT cord-267001-csgmc155 12 7 single single JJ cord-267001-csgmc155 12 8 inoculum inoculum NN cord-267001-csgmc155 12 9 . . . cord-267001-csgmc155 13 1 The the DT cord-267001-csgmc155 13 2 antibodies antibody NNS cord-267001-csgmc155 13 3 produced produce VBN cord-267001-csgmc155 13 4 also also RB cord-267001-csgmc155 13 5 significantly significantly RB cord-267001-csgmc155 13 6 inhibited inhibit VBD cord-267001-csgmc155 13 7 the the DT cord-267001-csgmc155 13 8 binding binding NN cord-267001-csgmc155 13 9 of of IN cord-267001-csgmc155 13 10 RBD RBD NNP cord-267001-csgmc155 13 11 to to IN cord-267001-csgmc155 13 12 its -PRON- PRP$ cord-267001-csgmc155 13 13 cell cell NN cord-267001-csgmc155 13 14 - - HYPH cord-267001-csgmc155 13 15 associated associate VBN cord-267001-csgmc155 13 16 receptor receptor NN cord-267001-csgmc155 13 17 . . . cord-267001-csgmc155 14 1 Moreover moreover RB cord-267001-csgmc155 14 2 , , , cord-267001-csgmc155 14 3 immunization immunization NN cord-267001-csgmc155 14 4 with with IN cord-267001-csgmc155 14 5 rASP-1 rASP-1 NNP cord-267001-csgmc155 14 6 co co NN cord-267001-csgmc155 14 7 - - VBN cord-267001-csgmc155 14 8 administered administer VBN cord-267001-csgmc155 14 9 with with IN cord-267001-csgmc155 14 10 the the DT cord-267001-csgmc155 14 11 alum alum NN cord-267001-csgmc155 14 12 - - HYPH cord-267001-csgmc155 14 13 adjuvanted adjuvante VBN cord-267001-csgmc155 14 14 RBD RBD NNP cord-267001-csgmc155 14 15 vaccine vaccine NN cord-267001-csgmc155 14 16 in in IN cord-267001-csgmc155 14 17 separate separate JJ cord-267001-csgmc155 14 18 sites site NNS cord-267001-csgmc155 14 19 resulted result VBD cord-267001-csgmc155 14 20 in in IN cord-267001-csgmc155 14 21 an an DT cord-267001-csgmc155 14 22 enhanced enhanced JJ cord-267001-csgmc155 14 23 frequency frequency NN cord-267001-csgmc155 14 24 of of IN cord-267001-csgmc155 14 25 TfH tfh NN cord-267001-csgmc155 14 26 and and CC cord-267001-csgmc155 14 27 GC GC NNP cord-267001-csgmc155 14 28 B B NNP cord-267001-csgmc155 14 29 cells cell NNS cord-267001-csgmc155 14 30 within within IN cord-267001-csgmc155 14 31 the the DT cord-267001-csgmc155 14 32 draining drain VBG cord-267001-csgmc155 14 33 lymph lymph NN cord-267001-csgmc155 14 34 nodes node NNS cord-267001-csgmc155 14 35 , , , cord-267001-csgmc155 14 36 both both DT cord-267001-csgmc155 14 37 of of IN cord-267001-csgmc155 14 38 which which WDT cord-267001-csgmc155 14 39 were be VBD cord-267001-csgmc155 14 40 positively positively RB cord-267001-csgmc155 14 41 associated associate VBN cord-267001-csgmc155 14 42 with with IN cord-267001-csgmc155 14 43 the the DT cord-267001-csgmc155 14 44 titers titer NNS cord-267001-csgmc155 14 45 of of IN cord-267001-csgmc155 14 46 the the DT cord-267001-csgmc155 14 47 neutralizing neutralize VBG cord-267001-csgmc155 14 48 antibody antibody NN cord-267001-csgmc155 14 49 response response NN cord-267001-csgmc155 14 50 related relate VBN cord-267001-csgmc155 14 51 to to IN cord-267001-csgmc155 14 52 anti anti JJ cord-267001-csgmc155 14 53 - - JJ cord-267001-csgmc155 14 54 MERS mers JJ cord-267001-csgmc155 14 55 - - HYPH cord-267001-csgmc155 14 56 CoV cov NN cord-267001-csgmc155 14 57 protective protective JJ cord-267001-csgmc155 14 58 immunity immunity NN cord-267001-csgmc155 14 59 . . . cord-267001-csgmc155 15 1 Our -PRON- PRP$ cord-267001-csgmc155 15 2 findings finding NNS cord-267001-csgmc155 15 3 not not RB cord-267001-csgmc155 15 4 only only RB cord-267001-csgmc155 15 5 indicate indicate VBP cord-267001-csgmc155 15 6 that that IN cord-267001-csgmc155 15 7 this this DT cord-267001-csgmc155 15 8 unique unique JJ cord-267001-csgmc155 15 9 combinatorial combinatorial JJ cord-267001-csgmc155 15 10 adjuvanted adjuvante VBN cord-267001-csgmc155 15 11 RBD RBD NNP cord-267001-csgmc155 15 12 vaccine vaccine NN cord-267001-csgmc155 15 13 regimen regimen NN cord-267001-csgmc155 15 14 improved improve VBD cord-267001-csgmc155 15 15 the the DT cord-267001-csgmc155 15 16 immunogenicity immunogenicity NN cord-267001-csgmc155 15 17 of of IN cord-267001-csgmc155 15 18 RBD RBD NNP cord-267001-csgmc155 15 19 , , , cord-267001-csgmc155 15 20 but but CC cord-267001-csgmc155 15 21 also also RB cord-267001-csgmc155 15 22 point point VBP cord-267001-csgmc155 15 23 to to IN cord-267001-csgmc155 15 24 the the DT cord-267001-csgmc155 15 25 importance importance NN cord-267001-csgmc155 15 26 of of IN cord-267001-csgmc155 15 27 utilizing utilize VBG cord-267001-csgmc155 15 28 combinatorial combinatorial JJ cord-267001-csgmc155 15 29 adjuvants adjuvant NNS cord-267001-csgmc155 15 30 for for IN cord-267001-csgmc155 15 31 the the DT cord-267001-csgmc155 15 32 induction induction NN cord-267001-csgmc155 15 33 of of IN cord-267001-csgmc155 15 34 synergistic synergistic JJ cord-267001-csgmc155 15 35 protective protective JJ cord-267001-csgmc155 15 36 immune immune JJ cord-267001-csgmc155 15 37 responses response NNS cord-267001-csgmc155 15 38 . . . cord-267001-csgmc155 16 1 Vaccination vaccination NN cord-267001-csgmc155 16 2 is be VBZ cord-267001-csgmc155 16 3 one one CD cord-267001-csgmc155 16 4 of of IN cord-267001-csgmc155 16 5 the the DT cord-267001-csgmc155 16 6 most most RBS cord-267001-csgmc155 16 7 successful successful JJ cord-267001-csgmc155 16 8 strategy strategy NN cord-267001-csgmc155 16 9 to to TO cord-267001-csgmc155 16 10 prevent prevent VB cord-267001-csgmc155 16 11 infectious infectious JJ cord-267001-csgmc155 16 12 diseases disease NNS cord-267001-csgmc155 16 13 in in IN cord-267001-csgmc155 16 14 the the DT cord-267001-csgmc155 16 15 human human JJ cord-267001-csgmc155 16 16 population population NN cord-267001-csgmc155 16 17 , , , cord-267001-csgmc155 16 18 including include VBG cord-267001-csgmc155 16 19 those those DT cord-267001-csgmc155 16 20 caused cause VBN cord-267001-csgmc155 16 21 by by IN cord-267001-csgmc155 16 22 emerging emerge VBG cord-267001-csgmc155 16 23 viruses virus NNS cord-267001-csgmc155 16 24 [ [ -LRB- cord-267001-csgmc155 16 25 1 1 CD cord-267001-csgmc155 16 26 ] ] -RRB- cord-267001-csgmc155 16 27 . . . cord-267001-csgmc155 17 1 Among among IN cord-267001-csgmc155 17 2 various various JJ cord-267001-csgmc155 17 3 vaccine vaccine NN cord-267001-csgmc155 17 4 types type NNS cord-267001-csgmc155 17 5 , , , cord-267001-csgmc155 17 6 such such JJ cord-267001-csgmc155 17 7 as as IN cord-267001-csgmc155 17 8 inactivated inactivate VBN cord-267001-csgmc155 17 9 virus virus NN cord-267001-csgmc155 17 10 , , , cord-267001-csgmc155 17 11 live live VB cord-267001-csgmc155 17 12 attenuated attenuated JJ cord-267001-csgmc155 17 13 virus virus NN cord-267001-csgmc155 17 14 , , , cord-267001-csgmc155 17 15 and and CC cord-267001-csgmc155 17 16 viral viral JJ cord-267001-csgmc155 17 17 vector vector NN cord-267001-csgmc155 17 18 - - HYPH cord-267001-csgmc155 17 19 based base VBN cord-267001-csgmc155 17 20 vaccines vaccine NNS cord-267001-csgmc155 17 21 , , , cord-267001-csgmc155 17 22 subunit subunit NN cord-267001-csgmc155 17 23 vaccines vaccine NNS cord-267001-csgmc155 17 24 using use VBG cord-267001-csgmc155 17 25 proteins protein NNS cord-267001-csgmc155 17 26 or or CC cord-267001-csgmc155 17 27 peptides peptide NNS cord-267001-csgmc155 17 28 are be VBP cord-267001-csgmc155 17 29 believed believe VBN cord-267001-csgmc155 17 30 to to TO cord-267001-csgmc155 17 31 be be VB cord-267001-csgmc155 17 32 much much RB cord-267001-csgmc155 17 33 safer safe JJR cord-267001-csgmc155 17 34 as as IN cord-267001-csgmc155 17 35 they -PRON- PRP cord-267001-csgmc155 17 36 do do VBP cord-267001-csgmc155 17 37 not not RB cord-267001-csgmc155 17 38 contain contain VB cord-267001-csgmc155 17 39 any any DT cord-267001-csgmc155 17 40 live live JJ cord-267001-csgmc155 17 41 virus virus NN cord-267001-csgmc155 17 42 components component NNS cord-267001-csgmc155 17 43 and/or and/or CC cord-267001-csgmc155 17 44 cause cause VB cord-267001-csgmc155 17 45 undesirable undesirable JJ cord-267001-csgmc155 17 46 severe severe JJ cord-267001-csgmc155 17 47 side side NN cord-267001-csgmc155 17 48 effects effect NNS cord-267001-csgmc155 17 49 [ [ -LRB- cord-267001-csgmc155 17 50 2 2 CD cord-267001-csgmc155 17 51 ] ] -RRB- cord-267001-csgmc155 17 52 . . . cord-267001-csgmc155 18 1 However however RB cord-267001-csgmc155 18 2 , , , cord-267001-csgmc155 18 3 unlike unlike IN cord-267001-csgmc155 18 4 attenuated attenuated JJ cord-267001-csgmc155 18 5 vaccines vaccine NNS cord-267001-csgmc155 18 6 ( ( -LRB- cord-267001-csgmc155 18 7 composed compose VBN cord-267001-csgmc155 18 8 of of IN cord-267001-csgmc155 18 9 a a DT cord-267001-csgmc155 18 10 virus virus NN cord-267001-csgmc155 18 11 or or CC cord-267001-csgmc155 18 12 bacterium bacterium NN cord-267001-csgmc155 18 13 that that WDT cord-267001-csgmc155 18 14 replicates replicate VBZ cord-267001-csgmc155 18 15 within within IN cord-267001-csgmc155 18 16 the the DT cord-267001-csgmc155 18 17 host host NN cord-267001-csgmc155 18 18 ) ) -RRB- cord-267001-csgmc155 18 19 or or CC cord-267001-csgmc155 18 20 inactivated inactivate VBN cord-267001-csgmc155 18 21 vaccines vaccine NNS cord-267001-csgmc155 18 22 ( ( -LRB- cord-267001-csgmc155 18 23 composed compose VBN cord-267001-csgmc155 18 24 of of IN cord-267001-csgmc155 18 25 either either CC cord-267001-csgmc155 18 26 heat heat NN cord-267001-csgmc155 18 27 or or CC cord-267001-csgmc155 18 28 chemically chemically RB cord-267001-csgmc155 18 29 - - HYPH cord-267001-csgmc155 18 30 inactivated inactivate VBN cord-267001-csgmc155 18 31 parts part NNS cord-267001-csgmc155 18 32 of of IN cord-267001-csgmc155 18 33 the the DT cord-267001-csgmc155 18 34 pathogen pathogen NN cord-267001-csgmc155 18 35 ) ) -RRB- cord-267001-csgmc155 18 36 , , , cord-267001-csgmc155 18 37 subunit subunit NN cord-267001-csgmc155 18 38 vaccines vaccine NNS cord-267001-csgmc155 18 39 ( ( -LRB- cord-267001-csgmc155 18 40 that that WDT cord-267001-csgmc155 18 41 are be VBP cord-267001-csgmc155 18 42 derived derive VBN cord-267001-csgmc155 18 43 from from IN cord-267001-csgmc155 18 44 known know VBN cord-267001-csgmc155 18 45 pathogen pathogen NN cord-267001-csgmc155 18 46 target target NN cord-267001-csgmc155 18 47 antigens antigen NNS cord-267001-csgmc155 18 48 ) ) -RRB- cord-267001-csgmc155 18 49 are be VBP cord-267001-csgmc155 18 50 generally generally RB cord-267001-csgmc155 18 51 much much RB cord-267001-csgmc155 18 52 less less RBR cord-267001-csgmc155 18 53 immunogenic immunogenic JJ cord-267001-csgmc155 18 54 , , , cord-267001-csgmc155 18 55 which which WDT cord-267001-csgmc155 18 56 can can MD cord-267001-csgmc155 18 57 be be VB cord-267001-csgmc155 18 58 improved improve VBN cord-267001-csgmc155 18 59 with with IN cord-267001-csgmc155 18 60 the the DT cord-267001-csgmc155 18 61 addition addition NN cord-267001-csgmc155 18 62 of of IN cord-267001-csgmc155 18 63 appropriate appropriate JJ cord-267001-csgmc155 18 64 adjuvant(s adjuvant(s NNP cord-267001-csgmc155 18 65 ) ) -RRB- cord-267001-csgmc155 18 66 to to IN cord-267001-csgmc155 18 67 the the DT cord-267001-csgmc155 18 68 vaccine vaccine NN cord-267001-csgmc155 18 69 [ [ -LRB- cord-267001-csgmc155 18 70 1 1 CD cord-267001-csgmc155 18 71 ] ] -RRB- cord-267001-csgmc155 18 72 . . . cord-267001-csgmc155 19 1 Adjuvants adjuvant NNS cord-267001-csgmc155 19 2 play play VBP cord-267001-csgmc155 19 3 an an DT cord-267001-csgmc155 19 4 important important JJ cord-267001-csgmc155 19 5 role role NN cord-267001-csgmc155 19 6 in in IN cord-267001-csgmc155 19 7 enhancing enhance VBG cord-267001-csgmc155 19 8 the the DT cord-267001-csgmc155 19 9 potency potency NN cord-267001-csgmc155 19 10 of of IN cord-267001-csgmc155 19 11 subunit subunit NN cord-267001-csgmc155 19 12 vaccines vaccine NNS cord-267001-csgmc155 19 13 by by IN cord-267001-csgmc155 19 14 improving improve VBG cord-267001-csgmc155 19 15 humoral humoral JJ cord-267001-csgmc155 19 16 and/or and/or CC cord-267001-csgmc155 19 17 cellular cellular JJ cord-267001-csgmc155 19 18 immune immune JJ cord-267001-csgmc155 19 19 responses response NNS cord-267001-csgmc155 19 20 to to IN cord-267001-csgmc155 19 21 the the DT cord-267001-csgmc155 19 22 various various JJ cord-267001-csgmc155 19 23 subunit subunit NN cord-267001-csgmc155 19 24 protein protein NN cord-267001-csgmc155 19 25 vaccines vaccine NNS cord-267001-csgmc155 19 26 , , , cord-267001-csgmc155 19 27 decreasing decrease VBG cord-267001-csgmc155 19 28 the the DT cord-267001-csgmc155 19 29 antigen antigen NN cord-267001-csgmc155 19 30 dosages dosage NNS cord-267001-csgmc155 19 31 , , , cord-267001-csgmc155 19 32 and/or and/or CC cord-267001-csgmc155 19 33 reducing reduce VBG cord-267001-csgmc155 19 34 immunization immunization NN cord-267001-csgmc155 19 35 regimens regimen NNS cord-267001-csgmc155 19 36 [ [ -LRB- cord-267001-csgmc155 19 37 3 3 CD cord-267001-csgmc155 19 38 , , , cord-267001-csgmc155 19 39 4 4 CD cord-267001-csgmc155 19 40 ] ] -RRB- cord-267001-csgmc155 19 41 . . . cord-267001-csgmc155 20 1 Aluminum aluminum NN cord-267001-csgmc155 20 2 salts salt NNS cord-267001-csgmc155 20 3 ( ( -LRB- cord-267001-csgmc155 20 4 hereinafter hereinafter NNP cord-267001-csgmc155 20 5 alum alum NN cord-267001-csgmc155 20 6 ) ) -RRB- cord-267001-csgmc155 21 1 C57BL/6 C57BL/6 NNP cord-267001-csgmc155 21 2 mice mouse NNS cord-267001-csgmc155 21 3 were be VBD cord-267001-csgmc155 21 4 immunized immunize VBN cord-267001-csgmc155 21 5 intramuscularly intramuscularly RB cord-267001-csgmc155 21 6 ( ( -LRB- cord-267001-csgmc155 21 7 i.m i.m NNP cord-267001-csgmc155 21 8 . . . cord-267001-csgmc155 21 9 ) ) -RRB- cord-267001-csgmc155 22 1 twice twice RB cord-267001-csgmc155 22 2 , , , cord-267001-csgmc155 22 3 three three CD cord-267001-csgmc155 22 4 weeks week NNS cord-267001-csgmc155 22 5 apart apart RB cord-267001-csgmc155 22 6 , , , cord-267001-csgmc155 22 7 with with IN cord-267001-csgmc155 22 8 MERS MERS NNP cord-267001-csgmc155 22 9 - - HYPH cord-267001-csgmc155 22 10 RBD RBD NNP cord-267001-csgmc155 22 11 - - HYPH cord-267001-csgmc155 22 12 Fd Fd NNP cord-267001-csgmc155 22 13 ( ( -LRB- cord-267001-csgmc155 22 14 5 5 CD cord-267001-csgmc155 22 15 µg µg NN cord-267001-csgmc155 22 16 ; ; : cord-267001-csgmc155 22 17 hereinafter hereinafter RB cord-267001-csgmc155 22 18 RBD RBD NNP cord-267001-csgmc155 22 19 ) ) -RRB- cord-267001-csgmc155 22 20 formulated formulate VBN cord-267001-csgmc155 22 21 with with IN cord-267001-csgmc155 22 22 or or CC cord-267001-csgmc155 22 23 without without IN cord-267001-csgmc155 22 24 alum alum NN cord-267001-csgmc155 23 1 ( ( -LRB- cord-267001-csgmc155 23 2 Alhydrogel Alhydrogel NNP cord-267001-csgmc155 23 3 ® ® VBP cord-267001-csgmc155 23 4 250 250 CD cord-267001-csgmc155 23 5 µg µg NN cord-267001-csgmc155 23 6 ) ) -RRB- cord-267001-csgmc155 24 1 ( ( -LRB- cord-267001-csgmc155 24 2 InvivoGen InvivoGen NNP cord-267001-csgmc155 24 3 , , , cord-267001-csgmc155 24 4 San San NNP cord-267001-csgmc155 24 5 Diego Diego NNP cord-267001-csgmc155 24 6 , , , cord-267001-csgmc155 24 7 CA CA NNP cord-267001-csgmc155 24 8 , , , cord-267001-csgmc155 24 9 USA USA NNP cord-267001-csgmc155 24 10 ) ) -RRB- cord-267001-csgmc155 24 11 , , , cord-267001-csgmc155 24 12 rASP-1 rASP-1 NNP cord-267001-csgmc155 24 13 ( ( -LRB- cord-267001-csgmc155 24 14 25 25 CD cord-267001-csgmc155 24 15 µg µg NN cord-267001-csgmc155 24 16 ) ) -RRB- cord-267001-csgmc155 24 17 , , , cord-267001-csgmc155 24 18 or or CC cord-267001-csgmc155 24 19 with with IN cord-267001-csgmc155 24 20 distinct distinct JJ cord-267001-csgmc155 24 21 adjuvant adjuvant JJ cord-267001-csgmc155 24 22 combinations combination NNS cord-267001-csgmc155 24 23 . . . cord-267001-csgmc155 25 1 Inoculums Inoculums NNP cord-267001-csgmc155 25 2 were be VBD cord-267001-csgmc155 25 3 prepared prepare VBN cord-267001-csgmc155 25 4 in in IN cord-267001-csgmc155 25 5 a a DT cord-267001-csgmc155 25 6 final final JJ cord-267001-csgmc155 25 7 volume volume NN cord-267001-csgmc155 25 8 of of IN cord-267001-csgmc155 25 9 100 100 CD cord-267001-csgmc155 25 10 µL µl CD cord-267001-csgmc155 25 11 per per IN cord-267001-csgmc155 25 12 mouse mouse NN cord-267001-csgmc155 25 13 and and CC cord-267001-csgmc155 25 14 50 50 CD cord-267001-csgmc155 25 15 µL µL NNP cord-267001-csgmc155 25 16 was be VBD cord-267001-csgmc155 25 17 injected inject VBN cord-267001-csgmc155 25 18 in in IN cord-267001-csgmc155 25 19 the the DT cord-267001-csgmc155 25 20 caudal caudal JJ cord-267001-csgmc155 25 21 thigh thigh NN cord-267001-csgmc155 25 22 muscle muscle NN cord-267001-csgmc155 25 23 of of IN cord-267001-csgmc155 25 24 each each DT cord-267001-csgmc155 25 25 hind hind NN cord-267001-csgmc155 25 26 leg leg NN cord-267001-csgmc155 25 27 in in IN cord-267001-csgmc155 25 28 the the DT cord-267001-csgmc155 25 29 appropriate appropriate JJ cord-267001-csgmc155 25 30 site site NN cord-267001-csgmc155 25 31 as as IN cord-267001-csgmc155 25 32 outlined outline VBN cord-267001-csgmc155 25 33 in in IN cord-267001-csgmc155 25 34 Table Table NNP cord-267001-csgmc155 25 35 1 1 CD cord-267001-csgmc155 25 36 . . . cord-267001-csgmc155 26 1 Control control NN cord-267001-csgmc155 26 2 mice mouse NNS cord-267001-csgmc155 26 3 were be VBD cord-267001-csgmc155 26 4 injected inject VBN cord-267001-csgmc155 26 5 with with IN cord-267001-csgmc155 26 6 PBS PBS NNP cord-267001-csgmc155 26 7 in in IN cord-267001-csgmc155 26 8 0.1 0.1 CD cord-267001-csgmc155 26 9 % % NN cord-267001-csgmc155 26 10 SDS SDS NNP cord-267001-csgmc155 26 11 , , , cord-267001-csgmc155 26 12 the the DT cord-267001-csgmc155 26 13 buffer buffer NN cord-267001-csgmc155 26 14 solution solution NN cord-267001-csgmc155 26 15 of of IN cord-267001-csgmc155 26 16 rASP-1 rasp-1 NN cord-267001-csgmc155 26 17 and and CC cord-267001-csgmc155 26 18 is be VBZ cord-267001-csgmc155 26 19 referred refer VBN cord-267001-csgmc155 26 20 to to IN cord-267001-csgmc155 26 21 as as RB cord-267001-csgmc155 26 22 naive naive JJ cord-267001-csgmc155 26 23 mice mouse NNS cord-267001-csgmc155 26 24 hereafter hereafter RB cord-267001-csgmc155 26 25 . . . cord-267001-csgmc155 27 1 Complete complete JJ cord-267001-csgmc155 27 2 adsorption adsorption NN cord-267001-csgmc155 27 3 of of IN cord-267001-csgmc155 27 4 the the DT cord-267001-csgmc155 27 5 RBD RBD NNP cord-267001-csgmc155 27 6 and and CC cord-267001-csgmc155 27 7 rASP-1 rasp-1 NN cord-267001-csgmc155 27 8 proteins protein NNS cord-267001-csgmc155 27 9 by by IN cord-267001-csgmc155 27 10 alum alum NN cord-267001-csgmc155 27 11 was be VBD cord-267001-csgmc155 27 12 confirmed confirm VBN cord-267001-csgmc155 27 13 by by IN cord-267001-csgmc155 27 14 SDS SDS NNP cord-267001-csgmc155 27 15 - - HYPH cord-267001-csgmc155 27 16 gel gel NN cord-267001-csgmc155 27 17 electrophoresis electrophoresis NN cord-267001-csgmc155 27 18 of of IN cord-267001-csgmc155 27 19 the the DT cord-267001-csgmc155 27 20 unbound unbound JJ cord-267001-csgmc155 27 21 protein protein NN cord-267001-csgmc155 27 22 samples sample NNS cord-267001-csgmc155 27 23 after after IN cord-267001-csgmc155 27 24 absorption absorption NN cord-267001-csgmc155 27 25 with with IN cord-267001-csgmc155 27 26 alum alum NN cord-267001-csgmc155 27 27 for for IN cord-267001-csgmc155 27 28 30 30 CD cord-267001-csgmc155 27 29 min min NN cord-267001-csgmc155 27 30 on on IN cord-267001-csgmc155 27 31 a a DT cord-267001-csgmc155 27 32 rotator rotator NN cord-267001-csgmc155 27 33 at at IN cord-267001-csgmc155 27 34 RT RT NNP cord-267001-csgmc155 27 35 . . . cord-267001-csgmc155 28 1 Sera Sera NNP cord-267001-csgmc155 28 2 samples sample NNS cord-267001-csgmc155 28 3 were be VBD cord-267001-csgmc155 28 4 collected collect VBN cord-267001-csgmc155 28 5 7 7 CD cord-267001-csgmc155 28 6 days day NNS cord-267001-csgmc155 28 7 post-2nd post-2nd JJ cord-267001-csgmc155 28 8 immunization immunization NN cord-267001-csgmc155 28 9 for for IN cord-267001-csgmc155 28 10 analyses analysis NNS cord-267001-csgmc155 28 11 of of IN cord-267001-csgmc155 28 12 anti anti JJ cord-267001-csgmc155 28 13 - - JJ cord-267001-csgmc155 28 14 MERS mers JJ cord-267001-csgmc155 28 15 - - HYPH cord-267001-csgmc155 28 16 CoV CoV NNP cord-267001-csgmc155 28 17 neutralizing neutralize VBG cord-267001-csgmc155 28 18 antibody antibody NN cord-267001-csgmc155 28 19 titers titer NNS cord-267001-csgmc155 28 20 , , , cord-267001-csgmc155 28 21 inhibition inhibition NN cord-267001-csgmc155 28 22 of of IN cord-267001-csgmc155 28 23 MERS MERS NNP cord-267001-csgmc155 28 24 - - HYPH cord-267001-csgmc155 28 25 CoV CoV NNP cord-267001-csgmc155 28 26 RBD RBD NNP cord-267001-csgmc155 28 27 - - HYPH cord-267001-csgmc155 28 28 DPP4 DPP4 NNP cord-267001-csgmc155 28 29 receptor receptor NN cord-267001-csgmc155 28 30 binding binding NN cord-267001-csgmc155 28 31 , , , cord-267001-csgmc155 28 32 and and CC cord-267001-csgmc155 28 33 MERS MERS NNP cord-267001-csgmc155 28 34 - - HYPH cord-267001-csgmc155 28 35 CoV cov NN cord-267001-csgmc155 28 36 RBD RBD NNP cord-267001-csgmc155 28 37 - - HYPH cord-267001-csgmc155 28 38 specific specific JJ cord-267001-csgmc155 28 39 antibody antibody NN cord-267001-csgmc155 28 40 responses response NNS cord-267001-csgmc155 28 41 using use VBG cord-267001-csgmc155 28 42 MERS MERS NNP cord-267001-csgmc155 28 43 - - HYPH cord-267001-csgmc155 28 44 CoV CoV NNP cord-267001-csgmc155 28 45 S1 S1 NNP cord-267001-csgmc155 28 46 as as IN cord-267001-csgmc155 28 47 a a DT cord-267001-csgmc155 28 48 target target NN cord-267001-csgmc155 28 49 . . . cord-267001-csgmc155 29 1 The the DT cord-267001-csgmc155 29 2 draining drain VBG cord-267001-csgmc155 29 3 lymph lymph NN cord-267001-csgmc155 29 4 nodes node NNS cord-267001-csgmc155 29 5 from from IN cord-267001-csgmc155 29 6 each each DT cord-267001-csgmc155 29 7 hind hind NN cord-267001-csgmc155 29 8 leg leg NN cord-267001-csgmc155 29 9 per per IN cord-267001-csgmc155 29 10 mouse mouse NN cord-267001-csgmc155 29 11 were be VBD cord-267001-csgmc155 29 12 also also RB cord-267001-csgmc155 29 13 recovered recover VBN cord-267001-csgmc155 29 14 at at IN cord-267001-csgmc155 29 15 day day NN cord-267001-csgmc155 29 16 7 7 CD cord-267001-csgmc155 29 17 post-2nd post-2nd NN cord-267001-csgmc155 29 18 immunization immunization NN cord-267001-csgmc155 29 19 for for IN cord-267001-csgmc155 29 20 analyses analysis NNS cord-267001-csgmc155 29 21 of of IN cord-267001-csgmc155 29 22 the the DT cord-267001-csgmc155 29 23 various various JJ cord-267001-csgmc155 29 24 cell cell NN cord-267001-csgmc155 29 25 profiles profile NNS cord-267001-csgmc155 29 26 within within RB cord-267001-csgmc155 29 27 . . . cord-267001-csgmc155 29 28 _SP cord-267001-csgmc155 30 1 The the DT cord-267001-csgmc155 30 2 neutralizing neutralize VBG cord-267001-csgmc155 30 3 activity activity NN cord-267001-csgmc155 30 4 of of IN cord-267001-csgmc155 30 5 sera sera NNP cord-267001-csgmc155 30 6 from from IN cord-267001-csgmc155 30 7 the the DT cord-267001-csgmc155 30 8 immunized immunize VBN cord-267001-csgmc155 30 9 mice mouse NNS cord-267001-csgmc155 30 10 against against IN cord-267001-csgmc155 30 11 MERS MERS NNP cord-267001-csgmc155 30 12 - - HYPH cord-267001-csgmc155 30 13 CoV cov NN cord-267001-csgmc155 30 14 infection infection NN cord-267001-csgmc155 30 15 in in IN cord-267001-csgmc155 30 16 vitro vitro FW cord-267001-csgmc155 30 17 was be VBD cord-267001-csgmc155 30 18 carried carry VBN cord-267001-csgmc155 30 19 out out RP cord-267001-csgmc155 30 20 using use VBG cord-267001-csgmc155 30 21 our -PRON- PRP$ cord-267001-csgmc155 30 22 established establish VBN cord-267001-csgmc155 30 23 pseudovirus pseudovirus JJ cord-267001-csgmc155 30 24 neutralization neutralization NN cord-267001-csgmc155 30 25 assay assay NN cord-267001-csgmc155 30 26 [ [ -LRB- cord-267001-csgmc155 30 27 17 17 CD cord-267001-csgmc155 30 28 , , , cord-267001-csgmc155 30 29 20 20 CD cord-267001-csgmc155 30 30 ] ] -RRB- cord-267001-csgmc155 30 31 . . . cord-267001-csgmc155 31 1 Briefly briefly RB cord-267001-csgmc155 31 2 , , , cord-267001-csgmc155 31 3 293 293 CD cord-267001-csgmc155 31 4 T t NN cord-267001-csgmc155 31 5 cells cell NNS cord-267001-csgmc155 31 6 were be VBD cord-267001-csgmc155 31 7 co co JJ cord-267001-csgmc155 31 8 - - VBN cord-267001-csgmc155 31 9 transfected transfecte VBN cord-267001-csgmc155 32 1 with with IN cord-267001-csgmc155 32 2 a a DT cord-267001-csgmc155 32 3 plasmid plasmid NN cord-267001-csgmc155 32 4 encoding encode VBG cord-267001-csgmc155 32 5 the the DT cord-267001-csgmc155 32 6 S S NNP cord-267001-csgmc155 32 7 protein protein NN cord-267001-csgmc155 32 8 of of IN cord-267001-csgmc155 32 9 MERS MERS NNP cord-267001-csgmc155 32 10 - - HYPH cord-267001-csgmc155 32 11 CoV CoV NNP cord-267001-csgmc155 32 12 ( ( -LRB- cord-267001-csgmc155 32 13 strain strain NN cord-267001-csgmc155 32 14 EMC2012 EMC2012 NNP cord-267001-csgmc155 32 15 ) ) -RRB- cord-267001-csgmc155 32 16 and and CC cord-267001-csgmc155 32 17 a a DT cord-267001-csgmc155 32 18 plasmid plasmid NN cord-267001-csgmc155 32 19 encoding encode VBG cord-267001-csgmc155 32 20 Env env NN cord-267001-csgmc155 32 21 - - HYPH cord-267001-csgmc155 32 22 defective defective JJ cord-267001-csgmc155 32 23 , , , cord-267001-csgmc155 32 24 luciferase luciferase NN cord-267001-csgmc155 32 25 - - HYPH cord-267001-csgmc155 32 26 expressing express VBG cord-267001-csgmc155 32 27 HIV-1 HIV-1 NNP cord-267001-csgmc155 32 28 genome genome NN cord-267001-csgmc155 32 29 ( ( -LRB- cord-267001-csgmc155 32 30 pNL4 pnl4 RB cord-267001-csgmc155 32 31 - - HYPH cord-267001-csgmc155 32 32 3.luc 3.luc CD cord-267001-csgmc155 32 33 . . . cord-267001-csgmc155 32 34 RE RE NNP cord-267001-csgmc155 32 35 ) ) -RRB- cord-267001-csgmc155 32 36 . . . cord-267001-csgmc155 33 1 The the DT cord-267001-csgmc155 33 2 supernatants supernatant NNS cord-267001-csgmc155 33 3 containing contain VBG cord-267001-csgmc155 33 4 MERS MERS NNP cord-267001-csgmc155 33 5 - - HYPH cord-267001-csgmc155 33 6 CoV CoV NNP cord-267001-csgmc155 33 7 S S NNP cord-267001-csgmc155 33 8 expressing express VBG cord-267001-csgmc155 33 9 pseudovirus pseudovirus NNP cord-267001-csgmc155 33 10 collected collect VBD cord-267001-csgmc155 33 11 72 72 CD cord-267001-csgmc155 33 12 h h NN cord-267001-csgmc155 33 13 post post NN cord-267001-csgmc155 33 14 - - NN cord-267001-csgmc155 33 15 transfection transfection NN cord-267001-csgmc155 33 16 were be VBD cord-267001-csgmc155 33 17 incubated incubate VBN cord-267001-csgmc155 33 18 with with IN cord-267001-csgmc155 33 19 serially serially RB cord-267001-csgmc155 33 20 diluted dilute VBN cord-267001-csgmc155 33 21 mouse mouse NN cord-267001-csgmc155 33 22 sera sera NNP cord-267001-csgmc155 33 23 at at IN cord-267001-csgmc155 33 24 37 37 CD cord-267001-csgmc155 33 25 • • NN cord-267001-csgmc155 33 26 C C NNP cord-267001-csgmc155 33 27 for for IN cord-267001-csgmc155 33 28 1 1 CD cord-267001-csgmc155 33 29 h. h. NN cord-267001-csgmc155 34 1 The the DT cord-267001-csgmc155 34 2 virus virus NN cord-267001-csgmc155 34 3 - - HYPH cord-267001-csgmc155 34 4 serum serum NN cord-267001-csgmc155 34 5 mixtures mixture NNS cord-267001-csgmc155 34 6 were be VBD cord-267001-csgmc155 34 7 then then RB cord-267001-csgmc155 34 8 added add VBN cord-267001-csgmc155 34 9 into into IN cord-267001-csgmc155 34 10 Huh-7 Huh-7 NNP cord-267001-csgmc155 34 11 cells cell NNS cord-267001-csgmc155 34 12 expressing express VBG cord-267001-csgmc155 34 13 the the DT cord-267001-csgmc155 34 14 MERS MERS NNP cord-267001-csgmc155 34 15 - - HYPH cord-267001-csgmc155 34 16 CoV CoV NNP cord-267001-csgmc155 34 17 receptor receptor NN cord-267001-csgmc155 34 18 DPP4 DPP4 NNP cord-267001-csgmc155 34 19 . . . cord-267001-csgmc155 35 1 The the DT cord-267001-csgmc155 35 2 cells cell NNS cord-267001-csgmc155 35 3 were be VBD cord-267001-csgmc155 35 4 refed refe VBN cord-267001-csgmc155 35 5 with with IN cord-267001-csgmc155 35 6 fresh fresh JJ cord-267001-csgmc155 35 7 medium medium JJ cord-267001-csgmc155 35 8 24 24 CD cord-267001-csgmc155 35 9 h h NN cord-267001-csgmc155 35 10 later later RB cord-267001-csgmc155 35 11 , , , cord-267001-csgmc155 35 12 and and CC cord-267001-csgmc155 35 13 after after IN cord-267001-csgmc155 35 14 72 72 CD cord-267001-csgmc155 35 15 h h NN cord-267001-csgmc155 35 16 , , , cord-267001-csgmc155 35 17 lysed lyse VBN cord-267001-csgmc155 35 18 using use VBG cord-267001-csgmc155 35 19 cell cell NN cord-267001-csgmc155 35 20 lysis lysis NN cord-267001-csgmc155 35 21 buffer buffer NN cord-267001-csgmc155 35 22 ( ( -LRB- cord-267001-csgmc155 35 23 Promega Promega NNP cord-267001-csgmc155 35 24 , , , cord-267001-csgmc155 35 25 Madison Madison NNP cord-267001-csgmc155 35 26 , , , cord-267001-csgmc155 35 27 WI WI NNP cord-267001-csgmc155 35 28 , , , cord-267001-csgmc155 35 29 USA USA NNP cord-267001-csgmc155 35 30 ) ) -RRB- cord-267001-csgmc155 35 31 before before IN cord-267001-csgmc155 35 32 the the DT cord-267001-csgmc155 35 33 supernatants supernatant NNS cord-267001-csgmc155 35 34 were be VBD cord-267001-csgmc155 35 35 transferred transfer VBN cord-267001-csgmc155 35 36 into into IN cord-267001-csgmc155 35 37 96-well 96-well CD cord-267001-csgmc155 35 38 luminometer luminometer NN cord-267001-csgmc155 35 39 plates plate NNS cord-267001-csgmc155 35 40 . . . cord-267001-csgmc155 36 1 After after IN cord-267001-csgmc155 36 2 addition addition NN cord-267001-csgmc155 36 3 of of IN cord-267001-csgmc155 36 4 luciferase luciferase NN cord-267001-csgmc155 36 5 substrate substrate NN cord-267001-csgmc155 36 6 ( ( -LRB- cord-267001-csgmc155 36 7 Promega Promega NNP cord-267001-csgmc155 36 8 , , , cord-267001-csgmc155 36 9 Madison Madison NNP cord-267001-csgmc155 36 10 , , , cord-267001-csgmc155 36 11 WI WI NNP cord-267001-csgmc155 36 12 , , , cord-267001-csgmc155 36 13 USA USA NNP cord-267001-csgmc155 36 14 ) ) -RRB- cord-267001-csgmc155 36 15 , , , cord-267001-csgmc155 36 16 the the DT cord-267001-csgmc155 36 17 plates plate NNS cord-267001-csgmc155 36 18 were be VBD cord-267001-csgmc155 36 19 measured measure VBN cord-267001-csgmc155 36 20 for for IN cord-267001-csgmc155 36 21 relative relative JJ cord-267001-csgmc155 36 22 luciferase luciferase NN cord-267001-csgmc155 36 23 activity activity NN cord-267001-csgmc155 36 24 using use VBG cord-267001-csgmc155 36 25 Infinite infinite JJ cord-267001-csgmc155 36 26 200 200 CD cord-267001-csgmc155 36 27 PRO PRO NNP cord-267001-csgmc155 36 28 Luminator Luminator NNP cord-267001-csgmc155 36 29 ( ( -LRB- cord-267001-csgmc155 36 30 Tecan Tecan NNP cord-267001-csgmc155 36 31 , , , cord-267001-csgmc155 36 32 Männedorf Männedorf NNP cord-267001-csgmc155 36 33 , , , cord-267001-csgmc155 36 34 Switzerland Switzerland NNP cord-267001-csgmc155 36 35 ) ) -RRB- cord-267001-csgmc155 36 36 . . . cord-267001-csgmc155 37 1 Neutralizing neutralize VBG cord-267001-csgmc155 37 2 activity activity NN cord-267001-csgmc155 37 3 was be VBD cord-267001-csgmc155 37 4 calculated calculate VBN cord-267001-csgmc155 37 5 using use VBG cord-267001-csgmc155 37 6 the the DT cord-267001-csgmc155 37 7 CalcuSyn CalcuSyn NNP cord-267001-csgmc155 37 8 computer computer NN cord-267001-csgmc155 37 9 program program NN cord-267001-csgmc155 37 10 [ [ -LRB- cord-267001-csgmc155 37 11 25 25 CD cord-267001-csgmc155 37 12 ] ] -RRB- cord-267001-csgmc155 37 13 and and CC cord-267001-csgmc155 37 14 is be VBZ cord-267001-csgmc155 37 15 expressed express VBN cord-267001-csgmc155 37 16 as as IN cord-267001-csgmc155 37 17 50 50 CD cord-267001-csgmc155 37 18 % % NN cord-267001-csgmc155 37 19 pseudovirus pseudovirus JJ cord-267001-csgmc155 37 20 neutralizing neutralize VBG cord-267001-csgmc155 37 21 antibody antibody NN cord-267001-csgmc155 37 22 titers titer NNS cord-267001-csgmc155 37 23 ( ( -LRB- cord-267001-csgmc155 37 24 NT NT NNP cord-267001-csgmc155 37 25 50 50 CD cord-267001-csgmc155 37 26 ) ) -RRB- cord-267001-csgmc155 37 27 . . . cord-267001-csgmc155 38 1 Sera Sera NNP cord-267001-csgmc155 38 2 from from IN cord-267001-csgmc155 38 3 immunized immunized JJ cord-267001-csgmc155 38 4 mice mouse NNS cord-267001-csgmc155 38 5 were be VBD cord-267001-csgmc155 38 6 tested test VBN cord-267001-csgmc155 38 7 for for IN cord-267001-csgmc155 38 8 their -PRON- PRP$ cord-267001-csgmc155 38 9 ability ability NN cord-267001-csgmc155 38 10 to to TO cord-267001-csgmc155 38 11 inhibit inhibit VB cord-267001-csgmc155 38 12 the the DT cord-267001-csgmc155 38 13 binding binding NN cord-267001-csgmc155 38 14 of of IN cord-267001-csgmc155 38 15 the the DT cord-267001-csgmc155 38 16 recombinant recombinant JJ cord-267001-csgmc155 38 17 MERS MERS NNP cord-267001-csgmc155 38 18 - - HYPH cord-267001-csgmc155 38 19 RBD RBD NNP cord-267001-csgmc155 38 20 - - HYPH cord-267001-csgmc155 38 21 Fc Fc NNP cord-267001-csgmc155 38 22 protein protein NN cord-267001-csgmc155 38 23 to to IN cord-267001-csgmc155 38 24 the the DT cord-267001-csgmc155 38 25 cell cell NN cord-267001-csgmc155 38 26 - - HYPH cord-267001-csgmc155 38 27 associated associate VBN cord-267001-csgmc155 38 28 hDPP4 hdpp4 NN cord-267001-csgmc155 38 29 receptor receptor NN cord-267001-csgmc155 38 30 in in IN cord-267001-csgmc155 38 31 Huh-7 Huh-7 NNP cord-267001-csgmc155 38 32 cells cell NNS cord-267001-csgmc155 38 33 using use VBG cord-267001-csgmc155 38 34 flow flow NN cord-267001-csgmc155 38 35 cytometry cytometry NN cord-267001-csgmc155 38 36 analysis analysis NN cord-267001-csgmc155 38 37 [ [ -LRB- cord-267001-csgmc155 38 38 26 26 CD cord-267001-csgmc155 38 39 ] ] -RRB- cord-267001-csgmc155 38 40 . . . cord-267001-csgmc155 39 1 Briefly briefly RB cord-267001-csgmc155 39 2 , , , cord-267001-csgmc155 39 3 cells cell NNS cord-267001-csgmc155 39 4 were be VBD cord-267001-csgmc155 39 5 incubated incubate VBN cord-267001-csgmc155 39 6 with with IN cord-267001-csgmc155 39 7 the the DT cord-267001-csgmc155 39 8 MERS MERS NNP cord-267001-csgmc155 39 9 - - HYPH cord-267001-csgmc155 39 10 RBD RBD NNP cord-267001-csgmc155 39 11 - - HYPH cord-267001-csgmc155 39 12 Fc Fc NNP cord-267001-csgmc155 39 13 protein protein NN cord-267001-csgmc155 39 14 ( ( -LRB- cord-267001-csgmc155 39 15 5 5 CD cord-267001-csgmc155 39 16 µg µg NN cord-267001-csgmc155 39 17 / / SYM cord-267001-csgmc155 39 18 mL mL NNP cord-267001-csgmc155 39 19 ) ) -RRB- cord-267001-csgmc155 39 20 in in IN cord-267001-csgmc155 39 21 the the DT cord-267001-csgmc155 39 22 presence presence NN cord-267001-csgmc155 39 23 or or CC cord-267001-csgmc155 39 24 absence absence NN cord-267001-csgmc155 39 25 of of IN cord-267001-csgmc155 39 26 diluted dilute VBN cord-267001-csgmc155 39 27 mouse mouse NN cord-267001-csgmc155 39 28 sera sera NNP cord-267001-csgmc155 39 29 ( ( -LRB- cord-267001-csgmc155 39 30 1:50 1:50 CD cord-267001-csgmc155 39 31 ) ) -RRB- cord-267001-csgmc155 39 32 for for IN cord-267001-csgmc155 39 33 30 30 CD cord-267001-csgmc155 39 34 min min NN cord-267001-csgmc155 39 35 at at IN cord-267001-csgmc155 39 36 room room NN cord-267001-csgmc155 39 37 temperature temperature NN cord-267001-csgmc155 39 38 . . . cord-267001-csgmc155 40 1 After after IN cord-267001-csgmc155 40 2 three three CD cord-267001-csgmc155 40 3 washes wash NNS cord-267001-csgmc155 40 4 and and CC cord-267001-csgmc155 40 5 staining stain VBG cord-267001-csgmc155 40 6 with with IN cord-267001-csgmc155 40 7 FITC FITC NNP cord-267001-csgmc155 40 8 - - HYPH cord-267001-csgmc155 40 9 labeled label VBN cord-267001-csgmc155 40 10 goat goat NN cord-267001-csgmc155 40 11 anti anti JJ cord-267001-csgmc155 40 12 - - JJ cord-267001-csgmc155 40 13 human human JJ cord-267001-csgmc155 40 14 IgG IgG NNP cord-267001-csgmc155 40 15 Fc Fc NNP cord-267001-csgmc155 40 16 secondary secondary JJ cord-267001-csgmc155 40 17 antibody antibody NN cord-267001-csgmc155 40 18 ( ( -LRB- cord-267001-csgmc155 40 19 1:500 1:500 CD cord-267001-csgmc155 40 20 , , , cord-267001-csgmc155 40 21 Thermo Thermo NNP cord-267001-csgmc155 40 22 Fisher Fisher NNP cord-267001-csgmc155 40 23 Scientific Scientific NNP cord-267001-csgmc155 40 24 , , , cord-267001-csgmc155 40 25 Waltham Waltham NNP cord-267001-csgmc155 40 26 , , , cord-267001-csgmc155 40 27 MA MA NNP cord-267001-csgmc155 40 28 , , , cord-267001-csgmc155 40 29 USA USA NNP cord-267001-csgmc155 40 30 ) ) -RRB- cord-267001-csgmc155 40 31 for for IN cord-267001-csgmc155 40 32 30 30 CD cord-267001-csgmc155 40 33 min min NN cord-267001-csgmc155 40 34 at at IN cord-267001-csgmc155 40 35 room room NN cord-267001-csgmc155 40 36 temperature temperature NN cord-267001-csgmc155 40 37 , , , cord-267001-csgmc155 40 38 the the DT cord-267001-csgmc155 40 39 cells cell NNS cord-267001-csgmc155 40 40 were be VBD cord-267001-csgmc155 40 41 measured measure VBN cord-267001-csgmc155 40 42 for for IN cord-267001-csgmc155 40 43 fluorescence fluorescence NN cord-267001-csgmc155 40 44 in in IN cord-267001-csgmc155 40 45 a a DT cord-267001-csgmc155 40 46 flow flow NN cord-267001-csgmc155 40 47 cytometer cytometer NN cord-267001-csgmc155 41 1 ( ( -LRB- cord-267001-csgmc155 41 2 BD BD NNP cord-267001-csgmc155 41 3 LSRFortessa LSRFortessa NNP cord-267001-csgmc155 41 4 4 4 CD cord-267001-csgmc155 41 5 system system NN cord-267001-csgmc155 41 6 ) ) -RRB- cord-267001-csgmc155 41 7 . . . cord-267001-csgmc155 42 1 Mean mean JJ cord-267001-csgmc155 42 2 fluorescence fluorescence NN cord-267001-csgmc155 42 3 intensity intensity NN cord-267001-csgmc155 42 4 ( ( -LRB- cord-267001-csgmc155 42 5 MFI MFI NNP cord-267001-csgmc155 42 6 ) ) -RRB- cord-267001-csgmc155 42 7 values value NNS cord-267001-csgmc155 42 8 of of IN cord-267001-csgmc155 42 9 the the DT cord-267001-csgmc155 42 10 FITC FITC NNP cord-267001-csgmc155 42 11 channel channel NN cord-267001-csgmc155 42 12 from from IN cord-267001-csgmc155 42 13 cells cell NNS cord-267001-csgmc155 42 14 incubated incubate VBN cord-267001-csgmc155 42 15 with with IN cord-267001-csgmc155 42 16 MERS MERS NNP cord-267001-csgmc155 42 17 - - HYPH cord-267001-csgmc155 42 18 RBD RBD NNP cord-267001-csgmc155 42 19 - - HYPH cord-267001-csgmc155 42 20 Fc Fc NNP cord-267001-csgmc155 42 21 protein protein NN cord-267001-csgmc155 42 22 in in IN cord-267001-csgmc155 42 23 the the DT cord-267001-csgmc155 42 24 absence absence NN cord-267001-csgmc155 42 25 of of IN cord-267001-csgmc155 42 26 diluted dilute VBN cord-267001-csgmc155 42 27 sera sera NNP cord-267001-csgmc155 42 28 were be VBD cord-267001-csgmc155 42 29 treated treat VBN cord-267001-csgmc155 42 30 as as IN cord-267001-csgmc155 42 31 100 100 CD cord-267001-csgmc155 42 32 percentage percentage NN cord-267001-csgmc155 42 33 binding binding NN cord-267001-csgmc155 42 34 . . . cord-267001-csgmc155 43 1 Inhibition inhibition NN cord-267001-csgmc155 43 2 of of IN cord-267001-csgmc155 43 3 binding binding NN cord-267001-csgmc155 43 4 was be VBD cord-267001-csgmc155 43 5 calculated calculate VBN cord-267001-csgmc155 43 6 as as IN cord-267001-csgmc155 43 7 the the DT cord-267001-csgmc155 43 8 percentage percentage NN cord-267001-csgmc155 43 9 of of IN cord-267001-csgmc155 43 10 reduced reduce VBN cord-267001-csgmc155 43 11 binding binding NN cord-267001-csgmc155 43 12 to to IN cord-267001-csgmc155 43 13 hDPP4 hdpp4 ADD cord-267001-csgmc155 43 14 receptor receptor NN cord-267001-csgmc155 43 15 in in IN cord-267001-csgmc155 43 16 the the DT cord-267001-csgmc155 43 17 presence presence NN cord-267001-csgmc155 43 18 of of IN cord-267001-csgmc155 43 19 diluted dilute VBN cord-267001-csgmc155 43 20 sera sera NNP cord-267001-csgmc155 43 21 from from IN cord-267001-csgmc155 43 22 the the DT cord-267001-csgmc155 43 23 different different JJ cord-267001-csgmc155 43 24 immunization immunization NN cord-267001-csgmc155 43 25 groups group NNS cord-267001-csgmc155 43 26 versus versus IN cord-267001-csgmc155 43 27 the the DT cord-267001-csgmc155 43 28 maximum maximum JJ cord-267001-csgmc155 43 29 binding binding NN cord-267001-csgmc155 43 30 observed observe VBN cord-267001-csgmc155 43 31 in in IN cord-267001-csgmc155 43 32 the the DT cord-267001-csgmc155 43 33 absence absence NN cord-267001-csgmc155 43 34 of of IN cord-267001-csgmc155 43 35 sera sera NNP cord-267001-csgmc155 43 36 . . . cord-267001-csgmc155 44 1 ELISA ELISA NNP cord-267001-csgmc155 44 2 to to TO cord-267001-csgmc155 44 3 measure measure VB cord-267001-csgmc155 44 4 MERS MERS NNP cord-267001-csgmc155 44 5 - - HYPH cord-267001-csgmc155 44 6 CoV cov NN cord-267001-csgmc155 44 7 RBD RBD NNP cord-267001-csgmc155 44 8 - - HYPH cord-267001-csgmc155 44 9 specific specific JJ cord-267001-csgmc155 44 10 antibody antibody NN cord-267001-csgmc155 44 11 responses response NNS cord-267001-csgmc155 44 12 in in IN cord-267001-csgmc155 44 13 immunized immunize VBN cord-267001-csgmc155 44 14 mouse mouse NN cord-267001-csgmc155 44 15 sera sera NNP cord-267001-csgmc155 44 16 was be VBD cord-267001-csgmc155 44 17 performed perform VBN cord-267001-csgmc155 44 18 with with IN cord-267001-csgmc155 44 19 MERS MERS NNP cord-267001-csgmc155 44 20 - - HYPH cord-267001-csgmc155 44 21 CoV CoV NNP cord-267001-csgmc155 44 22 S1 S1 NNP cord-267001-csgmc155 44 23 as as IN cord-267001-csgmc155 44 24 the the DT cord-267001-csgmc155 44 25 target target NN cord-267001-csgmc155 44 26 antigen antigen NN cord-267001-csgmc155 44 27 and and CC cord-267001-csgmc155 44 28 as as IN cord-267001-csgmc155 44 29 previously previously RB cord-267001-csgmc155 44 30 described describe VBN cord-267001-csgmc155 44 31 with with IN cord-267001-csgmc155 44 32 some some DT cord-267001-csgmc155 44 33 modifications modification NNS cord-267001-csgmc155 44 34 [ [ -LRB- cord-267001-csgmc155 44 35 17 17 CD cord-267001-csgmc155 44 36 , , , cord-267001-csgmc155 44 37 20 20 CD cord-267001-csgmc155 44 38 ] ] -RRB- cord-267001-csgmc155 44 39 . . . cord-267001-csgmc155 45 1 The the DT cord-267001-csgmc155 45 2 MERS MERS NNP cord-267001-csgmc155 45 3 - - HYPH cord-267001-csgmc155 45 4 CoV CoV NNP cord-267001-csgmc155 45 5 S1 S1 NNP cord-267001-csgmc155 45 6 subunit subunit NN cord-267001-csgmc155 45 7 of of IN cord-267001-csgmc155 45 8 the the DT cord-267001-csgmc155 45 9 MERS MERS NNP cord-267001-csgmc155 45 10 - - HYPH cord-267001-csgmc155 45 11 CoV CoV NNP cord-267001-csgmc155 45 12 S S NNP cord-267001-csgmc155 45 13 protein protein NN cord-267001-csgmc155 45 14 contains contain VBZ cord-267001-csgmc155 45 15 the the DT cord-267001-csgmc155 45 16 RBD RBD NNP cord-267001-csgmc155 45 17 region region NN cord-267001-csgmc155 45 18 of of IN cord-267001-csgmc155 45 19 the the DT cord-267001-csgmc155 45 20 virus virus NN cord-267001-csgmc155 45 21 . . . cord-267001-csgmc155 46 1 Briefly briefly RB cord-267001-csgmc155 46 2 , , , cord-267001-csgmc155 46 3 96-well 96-well CD cord-267001-csgmc155 46 4 ELISA ELISA NNP cord-267001-csgmc155 46 5 plates plate NNS cord-267001-csgmc155 46 6 were be VBD cord-267001-csgmc155 46 7 coated coat VBN cord-267001-csgmc155 46 8 with with IN cord-267001-csgmc155 46 9 MERS MERS NNP cord-267001-csgmc155 46 10 - - HYPH cord-267001-csgmc155 46 11 CoV CoV NNP cord-267001-csgmc155 46 12 S1 S1 NNP cord-267001-csgmc155 46 13 ( ( -LRB- cord-267001-csgmc155 46 14 1 1 CD cord-267001-csgmc155 46 15 µg µg NN cord-267001-csgmc155 46 16 / / SYM cord-267001-csgmc155 46 17 mL ml NN cord-267001-csgmc155 46 18 ) ) -RRB- cord-267001-csgmc155 46 19 overnight overnight RB cord-267001-csgmc155 46 20 at at IN cord-267001-csgmc155 46 21 4 4 CD cord-267001-csgmc155 47 1 • • NNP cord-267001-csgmc155 47 2 C C NNP cord-267001-csgmc155 47 3 , , , cord-267001-csgmc155 47 4 blocked block VBN cord-267001-csgmc155 47 5 with with IN cord-267001-csgmc155 47 6 2 2 CD cord-267001-csgmc155 47 7 % % NN cord-267001-csgmc155 47 8 fat fat NN cord-267001-csgmc155 47 9 - - HYPH cord-267001-csgmc155 47 10 free free JJ cord-267001-csgmc155 47 11 milk milk NN cord-267001-csgmc155 47 12 in in IN cord-267001-csgmc155 47 13 PBS PBS NNP cord-267001-csgmc155 47 14 containing contain VBG cord-267001-csgmc155 47 15 tween-20 tween-20 CD cord-267001-csgmc155 47 16 ( ( -LRB- cord-267001-csgmc155 47 17 PBST PBST NNP cord-267001-csgmc155 47 18 ) ) -RRB- cord-267001-csgmc155 47 19 at at IN cord-267001-csgmc155 47 20 37 37 CD cord-267001-csgmc155 47 21 • • NN cord-267001-csgmc155 47 22 C c NN cord-267001-csgmc155 47 23 for for IN cord-267001-csgmc155 47 24 2 2 CD cord-267001-csgmc155 47 25 h h NN cord-267001-csgmc155 47 26 , , , cord-267001-csgmc155 47 27 and and CC cord-267001-csgmc155 47 28 then then RB cord-267001-csgmc155 47 29 washed wash VBD cord-267001-csgmc155 47 30 with with IN cord-267001-csgmc155 47 31 PBST PBST NNP cord-267001-csgmc155 47 32 3 3 CD cord-267001-csgmc155 47 33 times time NNS cord-267001-csgmc155 47 34 . . . cord-267001-csgmc155 48 1 The the DT cord-267001-csgmc155 48 2 plates plate NNS cord-267001-csgmc155 48 3 were be VBD cord-267001-csgmc155 48 4 subsequently subsequently RB cord-267001-csgmc155 48 5 incubated incubate VBN cord-267001-csgmc155 48 6 at at IN cord-267001-csgmc155 48 7 37 37 CD cord-267001-csgmc155 48 8 • • NN cord-267001-csgmc155 48 9 C c NN cord-267001-csgmc155 48 10 for for IN cord-267001-csgmc155 48 11 1 1 CD cord-267001-csgmc155 48 12 h h NN cord-267001-csgmc155 48 13 with with IN cord-267001-csgmc155 48 14 serially serially RB cord-267001-csgmc155 48 15 diluted dilute VBN cord-267001-csgmc155 48 16 mouse mouse NN cord-267001-csgmc155 48 17 sera sera NNP cord-267001-csgmc155 48 18 , , , cord-267001-csgmc155 48 19 and and CC cord-267001-csgmc155 48 20 horseradish horseradish NN cord-267001-csgmc155 48 21 peroxidase peroxidase NN cord-267001-csgmc155 48 22 ( ( -LRB- cord-267001-csgmc155 48 23 HRP)-conjugated HRP)-conjugated NNP cord-267001-csgmc155 48 24 anti anti JJ cord-267001-csgmc155 48 25 - - JJ cord-267001-csgmc155 48 26 mouse mouse JJ cord-267001-csgmc155 48 27 IgG igg NN cord-267001-csgmc155 48 28 ( ( -LRB- cord-267001-csgmc155 48 29 1:5000 1:5000 NNP cord-267001-csgmc155 48 30 ) ) -RRB- cord-267001-csgmc155 48 31 , , , cord-267001-csgmc155 48 32 IgG1 igg1 FW cord-267001-csgmc155 48 33 ( ( -LRB- cord-267001-csgmc155 48 34 1:5000 1:5000 NNP cord-267001-csgmc155 48 35 ) ) -RRB- cord-267001-csgmc155 48 36 , , , cord-267001-csgmc155 48 37 or or CC cord-267001-csgmc155 48 38 IgG2c IgG2c NNP cord-267001-csgmc155 48 39 ( ( -LRB- cord-267001-csgmc155 48 40 1:2000 1:2000 LS cord-267001-csgmc155 48 41 ) ) -RRB- cord-267001-csgmc155 48 42 antibodies antibody NNS cord-267001-csgmc155 48 43 ( ( -LRB- cord-267001-csgmc155 48 44 Thermo Thermo NNP cord-267001-csgmc155 48 45 Fisher Fisher NNP cord-267001-csgmc155 48 46 Scientific Scientific NNP cord-267001-csgmc155 48 47 , , , cord-267001-csgmc155 48 48 Waltham Waltham NNP cord-267001-csgmc155 48 49 , , , cord-267001-csgmc155 48 50 MA MA NNP cord-267001-csgmc155 48 51 , , , cord-267001-csgmc155 48 52 USA USA NNP cord-267001-csgmc155 48 53 ) ) -RRB- cord-267001-csgmc155 48 54 . . . cord-267001-csgmc155 49 1 The the DT cord-267001-csgmc155 49 2 substrate substrate NN cord-267001-csgmc155 49 3 3,3 3,3 CD cord-267001-csgmc155 49 4 , , , cord-267001-csgmc155 49 5 5,5 5,5 CD cord-267001-csgmc155 49 6 -tetramethylbenzidine -tetramethylbenzidine NN cord-267001-csgmc155 50 1 ( ( -LRB- cord-267001-csgmc155 50 2 Sigma Sigma NNP cord-267001-csgmc155 50 3 - - HYPH cord-267001-csgmc155 50 4 Aldrich Aldrich NNP cord-267001-csgmc155 50 5 , , , cord-267001-csgmc155 50 6 St. St. NNP cord-267001-csgmc155 50 7 Louis Louis NNP cord-267001-csgmc155 50 8 , , , cord-267001-csgmc155 50 9 MO MO NNP cord-267001-csgmc155 50 10 , , , cord-267001-csgmc155 50 11 USA USA NNP cord-267001-csgmc155 50 12 ) ) -RRB- cord-267001-csgmc155 50 13 was be VBD cord-267001-csgmc155 50 14 added add VBN cord-267001-csgmc155 50 15 to to IN cord-267001-csgmc155 50 16 the the DT cord-267001-csgmc155 50 17 plates plate NNS cord-267001-csgmc155 50 18 after after IN cord-267001-csgmc155 50 19 additional additional JJ cord-267001-csgmc155 50 20 washes wash NNS cord-267001-csgmc155 50 21 , , , cord-267001-csgmc155 50 22 and and CC cord-267001-csgmc155 50 23 the the DT cord-267001-csgmc155 50 24 reaction reaction NN cord-267001-csgmc155 50 25 was be VBD cord-267001-csgmc155 50 26 stopped stop VBN cord-267001-csgmc155 50 27 by by IN cord-267001-csgmc155 50 28 the the DT cord-267001-csgmc155 50 29 addition addition NN cord-267001-csgmc155 50 30 of of IN cord-267001-csgmc155 50 31 1 1 CD cord-267001-csgmc155 50 32 N n NN cord-267001-csgmc155 50 33 H h NN cord-267001-csgmc155 50 34 2 2 CD cord-267001-csgmc155 50 35 SO so NN cord-267001-csgmc155 50 36 4 4 CD cord-267001-csgmc155 50 37 . . . cord-267001-csgmc155 51 1 Absorbance Absorbance NNP cord-267001-csgmc155 51 2 at at IN cord-267001-csgmc155 51 3 450 450 CD cord-267001-csgmc155 51 4 nm nm NN cord-267001-csgmc155 51 5 was be VBD cord-267001-csgmc155 51 6 measured measure VBN cord-267001-csgmc155 51 7 using use VBG cord-267001-csgmc155 51 8 an an DT cord-267001-csgmc155 51 9 ELISA ELISA NNP cord-267001-csgmc155 51 10 plate plate NN cord-267001-csgmc155 51 11 reader reader NN cord-267001-csgmc155 51 12 ( ( -LRB- cord-267001-csgmc155 51 13 Tecan Tecan NNP cord-267001-csgmc155 51 14 , , , cord-267001-csgmc155 51 15 Männedorf Männedorf NNP cord-267001-csgmc155 51 16 , , , cord-267001-csgmc155 51 17 Switzerland Switzerland NNP cord-267001-csgmc155 51 18 ) ) -RRB- cord-267001-csgmc155 51 19 . . . cord-267001-csgmc155 52 1 Endpoint endpoint NN cord-267001-csgmc155 52 2 titers titer NNS cord-267001-csgmc155 52 3 were be VBD cord-267001-csgmc155 52 4 calculated calculate VBN cord-267001-csgmc155 52 5 as as IN cord-267001-csgmc155 52 6 the the DT cord-267001-csgmc155 52 7 reciprocal reciprocal NN cord-267001-csgmc155 52 8 of of IN cord-267001-csgmc155 52 9 the the DT cord-267001-csgmc155 52 10 highest high JJS cord-267001-csgmc155 52 11 dilution dilution NN cord-267001-csgmc155 52 12 of of IN cord-267001-csgmc155 52 13 sera sera NNP cord-267001-csgmc155 52 14 giving give VBG cord-267001-csgmc155 52 15 an an DT cord-267001-csgmc155 52 16 optical optical JJ cord-267001-csgmc155 52 17 density density NN cord-267001-csgmc155 52 18 greater great JJR cord-267001-csgmc155 52 19 than than IN cord-267001-csgmc155 52 20 the the DT cord-267001-csgmc155 52 21 mean mean JJ cord-267001-csgmc155 52 22 ± ± NNP cord-267001-csgmc155 52 23 3 3 CD cord-267001-csgmc155 52 24 times time NNS cord-267001-csgmc155 52 25 the the DT cord-267001-csgmc155 52 26 standard standard JJ cord-267001-csgmc155 52 27 deviation deviation NN cord-267001-csgmc155 52 28 of of IN cord-267001-csgmc155 52 29 sera sera NNP cord-267001-csgmc155 52 30 from from IN cord-267001-csgmc155 52 31 naïve naïve JJ cord-267001-csgmc155 52 32 mice mouse NNS cord-267001-csgmc155 52 33 . . . cord-267001-csgmc155 53 1 Draining drain VBG cord-267001-csgmc155 53 2 lymph lymph NN cord-267001-csgmc155 53 3 nodes node NNS cord-267001-csgmc155 53 4 from from IN cord-267001-csgmc155 53 5 each each DT cord-267001-csgmc155 53 6 hind hind NN cord-267001-csgmc155 53 7 leg leg NN cord-267001-csgmc155 53 8 per per IN cord-267001-csgmc155 53 9 mouse mouse NN cord-267001-csgmc155 53 10 were be VBD cord-267001-csgmc155 53 11 harvested harvest VBN cord-267001-csgmc155 53 12 at at IN cord-267001-csgmc155 53 13 day day NN cord-267001-csgmc155 53 14 7 7 CD cord-267001-csgmc155 53 15 post-2nd post-2nd NN cord-267001-csgmc155 53 16 immunization immunization NN cord-267001-csgmc155 53 17 . . . cord-267001-csgmc155 54 1 The the DT cord-267001-csgmc155 54 2 lymph lymph NN cord-267001-csgmc155 54 3 nodes node NNS cord-267001-csgmc155 54 4 were be VBD cord-267001-csgmc155 54 5 dissociated dissociate VBN cord-267001-csgmc155 54 6 into into IN cord-267001-csgmc155 54 7 single single JJ cord-267001-csgmc155 54 8 cell cell NN cord-267001-csgmc155 54 9 suspensions suspension NNS cord-267001-csgmc155 54 10 using use VBG cord-267001-csgmc155 54 11 a a DT cord-267001-csgmc155 54 12 syringe syringe NN cord-267001-csgmc155 54 13 plunger plunger NN cord-267001-csgmc155 54 14 , , , cord-267001-csgmc155 54 15 then then RB cord-267001-csgmc155 54 16 passed pass VBD cord-267001-csgmc155 54 17 through through RP cord-267001-csgmc155 54 18 a a DT cord-267001-csgmc155 54 19 70 70 CD cord-267001-csgmc155 54 20 µm µm NN cord-267001-csgmc155 54 21 cell cell NN cord-267001-csgmc155 54 22 strainer strainer NN cord-267001-csgmc155 54 23 and and CC cord-267001-csgmc155 54 24 resuspended resuspend VBD cord-267001-csgmc155 54 25 in in IN cord-267001-csgmc155 54 26 complete complete JJ cord-267001-csgmc155 54 27 RPMI RPMI NNP cord-267001-csgmc155 54 28 1640 1640 CD cord-267001-csgmc155 54 29 media medium NNS cord-267001-csgmc155 54 30 containing contain VBG cord-267001-csgmc155 54 31 10 10 CD cord-267001-csgmc155 54 32 % % NN cord-267001-csgmc155 54 33 fetal fetal JJ cord-267001-csgmc155 54 34 bovine bovine JJ cord-267001-csgmc155 54 35 serum serum NN cord-267001-csgmc155 54 36 ( ( -LRB- cord-267001-csgmc155 54 37 R10 R10 NNP cord-267001-csgmc155 54 38 ) ) -RRB- cord-267001-csgmc155 54 39 . . . cord-267001-csgmc155 55 1 Subsequently subsequently RB cord-267001-csgmc155 55 2 , , , cord-267001-csgmc155 55 3 2.5 2.5 CD cord-267001-csgmc155 55 4 × × NN cord-267001-csgmc155 55 5 10 10 CD cord-267001-csgmc155 55 6 6 6 CD cord-267001-csgmc155 55 7 cells cell NNS cord-267001-csgmc155 55 8 were be VBD cord-267001-csgmc155 55 9 washed wash VBN cord-267001-csgmc155 55 10 and and CC cord-267001-csgmc155 55 11 resuspended resuspend VBN cord-267001-csgmc155 55 12 in in IN cord-267001-csgmc155 55 13 fresh fresh JJ cord-267001-csgmc155 55 14 R10 R10 NNP cord-267001-csgmc155 55 15 media medium NNS cord-267001-csgmc155 55 16 in in IN cord-267001-csgmc155 55 17 a a DT cord-267001-csgmc155 55 18 96-well 96-well CD cord-267001-csgmc155 55 19 cell cell NN cord-267001-csgmc155 55 20 culture culture NN cord-267001-csgmc155 55 21 plate plate NN cord-267001-csgmc155 55 22 for for IN cord-267001-csgmc155 55 23 flow flow NN cord-267001-csgmc155 55 24 cytometry cytometry NN cord-267001-csgmc155 55 25 staining staining NN cord-267001-csgmc155 55 26 . . . cord-267001-csgmc155 56 1 1.5 1.5 CD cord-267001-csgmc155 56 2 × × NN cord-267001-csgmc155 56 3 10 10 CD cord-267001-csgmc155 56 4 6 6 CD cord-267001-csgmc155 56 5 cells cell NNS cord-267001-csgmc155 56 6 were be VBD cord-267001-csgmc155 56 7 stained stain VBN cord-267001-csgmc155 56 8 with with IN cord-267001-csgmc155 56 9 a a DT cord-267001-csgmc155 56 10 labeled label VBN cord-267001-csgmc155 56 11 antibodies antibody NNS cord-267001-csgmc155 56 12 : : : cord-267001-csgmc155 56 13 CD45-AF700 CD45-AF700 NNP cord-267001-csgmc155 56 14 , , , cord-267001-csgmc155 57 1 CD11b CD11b NNPS cord-267001-csgmc155 57 2 - - HYPH cord-267001-csgmc155 57 3 PE pe NN cord-267001-csgmc155 57 4 - - HYPH cord-267001-csgmc155 57 5 Cy5 Cy5 NNP cord-267001-csgmc155 58 1 , , , cord-267001-csgmc155 58 2 CD11c CD11c NNP cord-267001-csgmc155 58 3 - - HYPH cord-267001-csgmc155 58 4 BV711 BV711 NNP cord-267001-csgmc155 58 5 , , , cord-267001-csgmc155 58 6 _SP cord-267001-csgmc155 58 7 Ly6C Ly6C NNP cord-267001-csgmc155 58 8 - - HYPH cord-267001-csgmc155 58 9 PerCP percp NN cord-267001-csgmc155 58 10 , , , cord-267001-csgmc155 58 11 CD40-APC cd40-apc NN cord-267001-csgmc155 58 12 , , , cord-267001-csgmc155 58 13 CCR7-PE CCR7-PE NNP cord-267001-csgmc155 58 14 , , , cord-267001-csgmc155 58 15 CD80-BV650 CD80-BV650 NNP cord-267001-csgmc155 58 16 , , , cord-267001-csgmc155 59 1 CD86-BV421 CD86-BV421 NNP cord-267001-csgmc155 59 2 , , , cord-267001-csgmc155 59 3 Ly6G Ly6G NNP cord-267001-csgmc155 59 4 - - HYPH cord-267001-csgmc155 59 5 PE pe NN cord-267001-csgmc155 59 6 - - HYPH cord-267001-csgmc155 59 7 Cy7 Cy7 NNP cord-267001-csgmc155 59 8 , , , cord-267001-csgmc155 59 9 and and CC cord-267001-csgmc155 59 10 B220-BV605 b220-bv605 NN cord-267001-csgmc155 59 11 . . . cord-267001-csgmc155 60 1 While while IN cord-267001-csgmc155 60 2 _SP cord-267001-csgmc155 60 3 1 1 CD cord-267001-csgmc155 60 4 × × NNP cord-267001-csgmc155 60 5 10 10 CD cord-267001-csgmc155 60 6 6 6 CD cord-267001-csgmc155 60 7 cells cell NNS cord-267001-csgmc155 60 8 were be VBD cord-267001-csgmc155 60 9 stained stain VBN cord-267001-csgmc155 60 10 with with IN cord-267001-csgmc155 60 11 a a DT cord-267001-csgmc155 60 12 cocktail cocktail NN cord-267001-csgmc155 60 13 of of IN cord-267001-csgmc155 60 14 the the DT cord-267001-csgmc155 60 15 following follow VBG cord-267001-csgmc155 60 16 fluorescently fluorescently RB cord-267001-csgmc155 60 17 labeled label VBN cord-267001-csgmc155 60 18 antibodies antibody NNS cord-267001-csgmc155 60 19 : : : cord-267001-csgmc155 60 20 CD45-AF700 CD45-AF700 NNP cord-267001-csgmc155 60 21 , , , cord-267001-csgmc155 60 22 _SP cord-267001-csgmc155 60 23 CD4-PE cd4-pe NN cord-267001-csgmc155 60 24 - - HYPH cord-267001-csgmc155 60 25 Cy7 Cy7 NNP cord-267001-csgmc155 60 26 , , , cord-267001-csgmc155 60 27 CXCR5-BV605 cxcr5-bv605 UH cord-267001-csgmc155 60 28 , , , cord-267001-csgmc155 60 29 PD-1-BV421 PD-1-BV421 NNPS cord-267001-csgmc155 60 30 , , , cord-267001-csgmc155 60 31 B220-BV650 B220-BV650 NNP cord-267001-csgmc155 61 1 and and CC cord-267001-csgmc155 61 2 GL-7-AF647 GL-7-AF647 NNP cord-267001-csgmc155 61 3 ( ( -LRB- cord-267001-csgmc155 61 4 all all DT cord-267001-csgmc155 61 5 from from IN cord-267001-csgmc155 61 6 Biolegend Biolegend NNP cord-267001-csgmc155 61 7 , , , cord-267001-csgmc155 61 8 San San NNP cord-267001-csgmc155 61 9 Diego Diego NNP cord-267001-csgmc155 61 10 , , , cord-267001-csgmc155 61 11 _SP cord-267001-csgmc155 61 12 CA CA NNP cord-267001-csgmc155 61 13 , , , cord-267001-csgmc155 61 14 USA USA NNP cord-267001-csgmc155 61 15 ) ) -RRB- cord-267001-csgmc155 61 16 , , , cord-267001-csgmc155 61 17 and and CC cord-267001-csgmc155 61 18 CD95-BV510 CD95-BV510 NNP cord-267001-csgmc155 61 19 ( ( -LRB- cord-267001-csgmc155 61 20 BD BD NNP cord-267001-csgmc155 61 21 Biosciences Biosciences NNP cord-267001-csgmc155 61 22 , , , cord-267001-csgmc155 61 23 Dublin Dublin NNP cord-267001-csgmc155 61 24 , , , cord-267001-csgmc155 61 25 Ireland Ireland NNP cord-267001-csgmc155 61 26 ) ) -RRB- cord-267001-csgmc155 61 27 , , , cord-267001-csgmc155 61 28 in in IN cord-267001-csgmc155 61 29 a a DT cord-267001-csgmc155 61 30 brilliant brilliant JJ cord-267001-csgmc155 61 31 violet violet JJ cord-267001-csgmc155 61 32 cell cell NN cord-267001-csgmc155 61 33 stain stain NN cord-267001-csgmc155 61 34 buffer buffer NN cord-267001-csgmc155 61 35 ( ( -LRB- cord-267001-csgmc155 61 36 BD BD NNP cord-267001-csgmc155 61 37 Biosciences Biosciences NNP cord-267001-csgmc155 61 38 , , , cord-267001-csgmc155 61 39 Dublin Dublin NNP cord-267001-csgmc155 61 40 , , , cord-267001-csgmc155 61 41 Ireland Ireland NNP cord-267001-csgmc155 61 42 ) ) -RRB- cord-267001-csgmc155 61 43 for for IN cord-267001-csgmc155 61 44 20 20 CD cord-267001-csgmc155 61 45 min min NN cord-267001-csgmc155 61 46 in in IN cord-267001-csgmc155 61 47 the the DT cord-267001-csgmc155 61 48 dark dark NN cord-267001-csgmc155 61 49 at at IN cord-267001-csgmc155 61 50 room room NN cord-267001-csgmc155 61 51 temperature temperature NN cord-267001-csgmc155 61 52 . . . cord-267001-csgmc155 62 1 Cells cell NNS cord-267001-csgmc155 62 2 were be VBD cord-267001-csgmc155 62 3 then then RB cord-267001-csgmc155 62 4 washed wash VBN cord-267001-csgmc155 62 5 , , , cord-267001-csgmc155 62 6 resuspended resuspend VBN cord-267001-csgmc155 62 7 in in IN cord-267001-csgmc155 62 8 cell cell NN cord-267001-csgmc155 62 9 stain stain NN cord-267001-csgmc155 62 10 buffer buffer NN cord-267001-csgmc155 62 11 ( ( -LRB- cord-267001-csgmc155 62 12 BioLegend BioLegend NNP cord-267001-csgmc155 62 13 , , , cord-267001-csgmc155 62 14 San San NNP cord-267001-csgmc155 62 15 Diego Diego NNP cord-267001-csgmc155 62 16 , , , cord-267001-csgmc155 62 17 CA CA NNP cord-267001-csgmc155 62 18 , , , cord-267001-csgmc155 62 19 USA USA NNP cord-267001-csgmc155 62 20 ) ) -RRB- cord-267001-csgmc155 62 21 , , , cord-267001-csgmc155 62 22 and and CC cord-267001-csgmc155 62 23 the the DT cord-267001-csgmc155 62 24 number number NN cord-267001-csgmc155 62 25 of of IN cord-267001-csgmc155 62 26 stained stained JJ cord-267001-csgmc155 62 27 cells cell NNS cord-267001-csgmc155 62 28 was be VBD cord-267001-csgmc155 62 29 acquired acquire VBN cord-267001-csgmc155 62 30 using use VBG cord-267001-csgmc155 62 31 BD BD NNP cord-267001-csgmc155 62 32 LSRFortessa LSRFortessa NNP cord-267001-csgmc155 62 33 cell cell NN cord-267001-csgmc155 62 34 analyzer analyzer NN cord-267001-csgmc155 62 35 ( ( -LRB- cord-267001-csgmc155 62 36 BD BD NNP cord-267001-csgmc155 62 37 Biosciences Biosciences NNP cord-267001-csgmc155 62 38 , , , cord-267001-csgmc155 62 39 Dublin Dublin NNP cord-267001-csgmc155 62 40 , , , cord-267001-csgmc155 62 41 Ireland Ireland NNP cord-267001-csgmc155 62 42 ) ) -RRB- cord-267001-csgmc155 62 43 . . . cord-267001-csgmc155 63 1 The the DT cord-267001-csgmc155 63 2 data datum NNS cord-267001-csgmc155 63 3 were be VBD cord-267001-csgmc155 63 4 analyzed analyze VBN cord-267001-csgmc155 63 5 using use VBG cord-267001-csgmc155 63 6 Flowjo Flowjo NNP cord-267001-csgmc155 63 7 Software Software NNP cord-267001-csgmc155 63 8 ( ( -LRB- cord-267001-csgmc155 63 9 Tree Tree NNP cord-267001-csgmc155 63 10 Star Star NNP cord-267001-csgmc155 63 11 , , , cord-267001-csgmc155 63 12 Ashland Ashland NNP cord-267001-csgmc155 63 13 , , , cord-267001-csgmc155 63 14 OR or CC cord-267001-csgmc155 63 15 , , , cord-267001-csgmc155 63 16 USA USA NNP cord-267001-csgmc155 63 17 ) ) -RRB- cord-267001-csgmc155 63 18 . . . cord-267001-csgmc155 64 1 CD45 CD45 NNP cord-267001-csgmc155 64 2 + + CC cord-267001-csgmc155 65 1 CD11c CD11c NNP cord-267001-csgmc155 66 1 -Ly6C -Ly6C NNP cord-267001-csgmc155 67 1 + + CC cord-267001-csgmc155 67 2 cells cell NNS cord-267001-csgmc155 67 3 were be VBD cord-267001-csgmc155 67 4 identified identify VBN cord-267001-csgmc155 67 5 as as IN cord-267001-csgmc155 67 6 monocytes monocyte NNS cord-267001-csgmc155 67 7 , , , cord-267001-csgmc155 67 8 CD45 CD45 NNP cord-267001-csgmc155 67 9 + + CC cord-267001-csgmc155 67 10 CD11c CD11c NNP cord-267001-csgmc155 67 11 -Ly6C -Ly6C NNP cord-267001-csgmc155 68 1 + + CC cord-267001-csgmc155 69 1 CD40 CD40 NNP cord-267001-csgmc155 69 2 + + CC cord-267001-csgmc155 69 3 cells cell NNS cord-267001-csgmc155 69 4 were be VBD cord-267001-csgmc155 69 5 identified identify VBN cord-267001-csgmc155 69 6 as as IN cord-267001-csgmc155 69 7 activated activate VBN cord-267001-csgmc155 69 8 monocytes monocyte NNS cord-267001-csgmc155 69 9 , , , cord-267001-csgmc155 69 10 CD45 CD45 NNP cord-267001-csgmc155 69 11 + + CC cord-267001-csgmc155 69 12 CD11c CD11c NNP cord-267001-csgmc155 70 1 -Ly6C -Ly6C NNP cord-267001-csgmc155 71 1 + + CC cord-267001-csgmc155 72 1 CCR7 CCR7 NNP cord-267001-csgmc155 72 2 + + CC cord-267001-csgmc155 72 3 cells cell NNS cord-267001-csgmc155 72 4 were be VBD cord-267001-csgmc155 72 5 identified identify VBN cord-267001-csgmc155 72 6 as as IN cord-267001-csgmc155 72 7 migratory migratory JJ cord-267001-csgmc155 72 8 monocytes monocyte NNS cord-267001-csgmc155 72 9 , , , cord-267001-csgmc155 72 10 CD45 CD45 NNP cord-267001-csgmc155 72 11 + + CC cord-267001-csgmc155 72 12 CD4 CD4 NNP cord-267001-csgmc155 72 13 + + CC cord-267001-csgmc155 72 14 cells cell NNS cord-267001-csgmc155 72 15 were be VBD cord-267001-csgmc155 72 16 identified identify VBN cord-267001-csgmc155 72 17 as as IN cord-267001-csgmc155 72 18 CD4 CD4 NNP cord-267001-csgmc155 72 19 + + CC cord-267001-csgmc155 72 20 T t NN cord-267001-csgmc155 72 21 cells cell NNS cord-267001-csgmc155 72 22 , , , cord-267001-csgmc155 72 23 CD45 CD45 NNP cord-267001-csgmc155 72 24 + + CC cord-267001-csgmc155 72 25 CD4 CD4 NNP cord-267001-csgmc155 72 26 + + CC cord-267001-csgmc155 72 27 CXCR5 cxcr5 XX cord-267001-csgmc155 73 1 + + CC cord-267001-csgmc155 74 1 PD-1 PD-1 NNP cord-267001-csgmc155 75 1 + + CC cord-267001-csgmc155 75 2 cells cell NNS cord-267001-csgmc155 75 3 were be VBD cord-267001-csgmc155 75 4 identified identify VBN cord-267001-csgmc155 75 5 as as IN cord-267001-csgmc155 75 6 TfH tfh NN cord-267001-csgmc155 75 7 cells cell NNS cord-267001-csgmc155 75 8 , , , cord-267001-csgmc155 75 9 CD45 CD45 NNP cord-267001-csgmc155 75 10 + + CC cord-267001-csgmc155 75 11 B220 B220 NNP cord-267001-csgmc155 76 1 + + CC cord-267001-csgmc155 76 2 cells cell NNS cord-267001-csgmc155 76 3 were be VBD cord-267001-csgmc155 76 4 identified identify VBN cord-267001-csgmc155 76 5 as as IN cord-267001-csgmc155 76 6 B b NN cord-267001-csgmc155 76 7 cells cell NNS cord-267001-csgmc155 76 8 and and CC cord-267001-csgmc155 76 9 CD45 CD45 NNP cord-267001-csgmc155 76 10 + + CC cord-267001-csgmc155 76 11 B220 B220 NNP cord-267001-csgmc155 76 12 + + SYM cord-267001-csgmc155 76 13 CD95 CD95 NNP cord-267001-csgmc155 76 14 + + -RRB- cord-267001-csgmc155 77 1 GL-7 GL-7 NNP cord-267001-csgmc155 77 2 + + CC cord-267001-csgmc155 77 3 cells cell NNS cord-267001-csgmc155 77 4 were be VBD cord-267001-csgmc155 77 5 identified identify VBN cord-267001-csgmc155 77 6 as as IN cord-267001-csgmc155 77 7 GC GC NNP cord-267001-csgmc155 77 8 B B NNP cord-267001-csgmc155 77 9 cells cell NNS cord-267001-csgmc155 77 10 . . . cord-267001-csgmc155 78 1 One one CD cord-267001-csgmc155 78 2 - - HYPH cord-267001-csgmc155 78 3 way way NN cord-267001-csgmc155 78 4 ANOVA anova NN cord-267001-csgmc155 78 5 test test NN cord-267001-csgmc155 78 6 with with IN cord-267001-csgmc155 78 7 Tukey Tukey NNP cord-267001-csgmc155 78 8 's 's POS cord-267001-csgmc155 78 9 multiple multiple JJ cord-267001-csgmc155 78 10 comparison comparison NN cord-267001-csgmc155 78 11 was be VBD cord-267001-csgmc155 78 12 used use VBN cord-267001-csgmc155 78 13 for for IN cord-267001-csgmc155 78 14 statistical statistical JJ cord-267001-csgmc155 78 15 analysis analysis NN cord-267001-csgmc155 78 16 using use VBG cord-267001-csgmc155 78 17 GraphPad GraphPad NNP cord-267001-csgmc155 78 18 Prism Prism NNP cord-267001-csgmc155 78 19 v6 v6 NN cord-267001-csgmc155 78 20 ( ( -LRB- cord-267001-csgmc155 78 21 GraphPad GraphPad NNP cord-267001-csgmc155 78 22 , , , cord-267001-csgmc155 78 23 San San NNP cord-267001-csgmc155 78 24 Diego Diego NNP cord-267001-csgmc155 78 25 , , , cord-267001-csgmc155 78 26 CA CA NNP cord-267001-csgmc155 78 27 , , , cord-267001-csgmc155 78 28 USA USA NNP cord-267001-csgmc155 78 29 ) ) -RRB- cord-267001-csgmc155 78 30 . . . cord-267001-csgmc155 79 1 Spearman Spearman NNP cord-267001-csgmc155 79 2 correlation correlation NN cord-267001-csgmc155 79 3 was be VBD cord-267001-csgmc155 79 4 performed perform VBN cord-267001-csgmc155 79 5 to to TO cord-267001-csgmc155 79 6 determine determine VB cord-267001-csgmc155 79 7 the the DT cord-267001-csgmc155 79 8 association association NN cord-267001-csgmc155 79 9 of of IN cord-267001-csgmc155 79 10 the the DT cord-267001-csgmc155 79 11 fold fold JJ cord-267001-csgmc155 79 12 increase increase NN cord-267001-csgmc155 79 13 in in IN cord-267001-csgmc155 79 14 the the DT cord-267001-csgmc155 79 15 frequency frequency NN cord-267001-csgmc155 79 16 of of IN cord-267001-csgmc155 79 17 TfH tfh NN cord-267001-csgmc155 79 18 and and CC cord-267001-csgmc155 79 19 GC GC NNP cord-267001-csgmc155 79 20 B B NNP cord-267001-csgmc155 79 21 cells cell NNS cord-267001-csgmc155 79 22 with with IN cord-267001-csgmc155 79 23 neutralizing neutralize VBG cord-267001-csgmc155 79 24 antibody antibody NN cord-267001-csgmc155 79 25 titers titer NNS cord-267001-csgmc155 79 26 using use VBG cord-267001-csgmc155 79 27 GraphPad GraphPad NNP cord-267001-csgmc155 79 28 Prism Prism NNP cord-267001-csgmc155 79 29 v6 v6 NN cord-267001-csgmc155 79 30 ( ( -LRB- cord-267001-csgmc155 79 31 GraphPad GraphPad NNP cord-267001-csgmc155 79 32 , , , cord-267001-csgmc155 79 33 San San NNP cord-267001-csgmc155 79 34 Diego Diego NNP cord-267001-csgmc155 79 35 , , , cord-267001-csgmc155 79 36 CA CA NNP cord-267001-csgmc155 79 37 , , , cord-267001-csgmc155 79 38 USA USA NNP cord-267001-csgmc155 79 39 ) ) -RRB- cord-267001-csgmc155 79 40 . . . cord-267001-csgmc155 80 1 p p NN cord-267001-csgmc155 80 2 < < XX cord-267001-csgmc155 80 3 0.05 0.05 CD cord-267001-csgmc155 80 4 : : : cord-267001-csgmc155 81 1 * * NFP cord-267001-csgmc155 81 2 , , , cord-267001-csgmc155 81 3 p p NN cord-267001-csgmc155 81 4 < < XX cord-267001-csgmc155 81 5 0.01 0.01 CD cord-267001-csgmc155 81 6 : : : cord-267001-csgmc155 82 1 * * NFP cord-267001-csgmc155 82 2 * * NFP cord-267001-csgmc155 82 3 , , , cord-267001-csgmc155 82 4 p p NN cord-267001-csgmc155 82 5 < < XX cord-267001-csgmc155 82 6 0.001 0.001 CD cord-267001-csgmc155 82 7 : : : cord-267001-csgmc155 83 1 * * NFP cord-267001-csgmc155 83 2 * * NFP cord-267001-csgmc155 83 3 * * NFP cord-267001-csgmc155 83 4 , , , cord-267001-csgmc155 83 5 p p NN cord-267001-csgmc155 83 6 < < XX cord-267001-csgmc155 83 7 0.0001 0.0001 CD cord-267001-csgmc155 83 8 : : : cord-267001-csgmc155 84 1 * * NFP cord-267001-csgmc155 84 2 * * NFP cord-267001-csgmc155 84 3 * * NFP cord-267001-csgmc155 84 4 * * NFP cord-267001-csgmc155 84 5 . . . cord-267001-csgmc155 84 6 ND ND NNP cord-267001-csgmc155 84 7 : : : cord-267001-csgmc155 84 8 not not RB cord-267001-csgmc155 84 9 detectable detectable JJ cord-267001-csgmc155 84 10 . . . cord-267001-csgmc155 85 1 To to TO cord-267001-csgmc155 85 2 investigate investigate VB cord-267001-csgmc155 85 3 whether whether IN cord-267001-csgmc155 85 4 rASP-1 rASP-1 VBN cord-267001-csgmc155 85 5 in in IN cord-267001-csgmc155 85 6 combination combination NN cord-267001-csgmc155 85 7 with with IN cord-267001-csgmc155 85 8 alum alum NN cord-267001-csgmc155 85 9 enhances enhance VBZ cord-267001-csgmc155 85 10 the the DT cord-267001-csgmc155 85 11 humoral humoral JJ cord-267001-csgmc155 85 12 immune immune JJ cord-267001-csgmc155 85 13 responses response NNS cord-267001-csgmc155 85 14 induced induce VBN cord-267001-csgmc155 85 15 by by IN cord-267001-csgmc155 85 16 the the DT cord-267001-csgmc155 85 17 MRES MRES NNP cord-267001-csgmc155 85 18 - - HYPH cord-267001-csgmc155 85 19 RBD RBD NNP cord-267001-csgmc155 85 20 - - HYPH cord-267001-csgmc155 85 21 Fd Fd NNP cord-267001-csgmc155 85 22 ( ( -LRB- cord-267001-csgmc155 85 23 herein herein RB cord-267001-csgmc155 85 24 after after IN cord-267001-csgmc155 85 25 RBD RBD NNP cord-267001-csgmc155 85 26 ) ) -RRB- cord-267001-csgmc155 85 27 vaccine vaccine NN cord-267001-csgmc155 85 28 , , , cord-267001-csgmc155 85 29 we -PRON- PRP cord-267001-csgmc155 85 30 immunized immunize VBD cord-267001-csgmc155 85 31 C57BL/6 C57BL/6 NNP cord-267001-csgmc155 85 32 mice mouse NNS cord-267001-csgmc155 85 33 twice twice RB cord-267001-csgmc155 85 34 . . . cord-267001-csgmc155 86 1 three three CD cord-267001-csgmc155 86 2 weeks week NNS cord-267001-csgmc155 86 3 apart apart RB cord-267001-csgmc155 86 4 , , , cord-267001-csgmc155 86 5 using use VBG cord-267001-csgmc155 86 6 a a DT cord-267001-csgmc155 86 7 formulation formulation NN cord-267001-csgmc155 86 8 where where WRB cord-267001-csgmc155 86 9 rASP-1 rasp-1 NN cord-267001-csgmc155 86 10 and and CC cord-267001-csgmc155 86 11 the the DT cord-267001-csgmc155 86 12 RBD RBD NNP cord-267001-csgmc155 86 13 vaccine vaccine NN cord-267001-csgmc155 86 14 proteins protein NNS cord-267001-csgmc155 86 15 were be VBD cord-267001-csgmc155 86 16 completely completely RB cord-267001-csgmc155 86 17 adsorbed adsorb VBN cord-267001-csgmc155 86 18 to to IN cord-267001-csgmc155 86 19 alum alum NN cord-267001-csgmc155 86 20 and and CC cord-267001-csgmc155 86 21 then then RB cord-267001-csgmc155 86 22 administered administer VBN cord-267001-csgmc155 86 23 as as IN cord-267001-csgmc155 86 24 a a DT cord-267001-csgmc155 86 25 single single JJ cord-267001-csgmc155 86 26 inoculum inoculum NN cord-267001-csgmc155 86 27 ( ( -LRB- cord-267001-csgmc155 86 28 Table table NN cord-267001-csgmc155 86 29 1 1 CD cord-267001-csgmc155 86 30 ; ; : cord-267001-csgmc155 86 31 Group group NN cord-267001-csgmc155 86 32 5 5 CD cord-267001-csgmc155 86 33 ) ) -RRB- cord-267001-csgmc155 86 34 . . . cord-267001-csgmc155 87 1 This this DT cord-267001-csgmc155 87 2 adjuvanted adjuvanted JJ cord-267001-csgmc155 87 3 vaccine vaccine NN cord-267001-csgmc155 87 4 was be VBD cord-267001-csgmc155 87 5 compared compare VBN cord-267001-csgmc155 87 6 to to IN cord-267001-csgmc155 87 7 that that DT cord-267001-csgmc155 87 8 in in IN cord-267001-csgmc155 87 9 which which WDT cord-267001-csgmc155 87 10 rASP-1 rasp-1 NN cord-267001-csgmc155 87 11 was be VBD cord-267001-csgmc155 87 12 co co VBN cord-267001-csgmc155 87 13 - - VBN cord-267001-csgmc155 87 14 administered administer VBN cord-267001-csgmc155 87 15 with with IN cord-267001-csgmc155 87 16 the the DT cord-267001-csgmc155 87 17 alum alum NN cord-267001-csgmc155 87 18 - - HYPH cord-267001-csgmc155 87 19 adjuvanted adjuvante VBN cord-267001-csgmc155 87 20 RBD RBD NNP cord-267001-csgmc155 87 21 vaccine vaccine NN cord-267001-csgmc155 87 22 as as IN cord-267001-csgmc155 87 23 two two CD cord-267001-csgmc155 87 24 inoculums inoculum NNS cord-267001-csgmc155 87 25 and and CC cord-267001-csgmc155 87 26 in in IN cord-267001-csgmc155 87 27 two two CD cord-267001-csgmc155 87 28 separate separate JJ cord-267001-csgmc155 87 29 sites site NNS cord-267001-csgmc155 87 30 of of IN cord-267001-csgmc155 87 31 the the DT cord-267001-csgmc155 87 32 caudal caudal JJ cord-267001-csgmc155 87 33 thigh thigh NN cord-267001-csgmc155 87 34 muscle muscle NN cord-267001-csgmc155 87 35 ( ( -LRB- cord-267001-csgmc155 87 36 Table table NN cord-267001-csgmc155 87 37 1 1 CD cord-267001-csgmc155 87 38 ; ; : cord-267001-csgmc155 87 39 Group Group NNP cord-267001-csgmc155 87 40 6 6 CD cord-267001-csgmc155 87 41 ) ) -RRB- cord-267001-csgmc155 87 42 . . . cord-267001-csgmc155 88 1 RBD RBD NNP cord-267001-csgmc155 88 2 formulated formulate VBD cord-267001-csgmc155 88 3 with with IN cord-267001-csgmc155 88 4 either either CC cord-267001-csgmc155 88 5 rASP-1 rasp-1 NN cord-267001-csgmc155 88 6 or or CC cord-267001-csgmc155 88 7 alum alum NN cord-267001-csgmc155 88 8 alone alone RB cord-267001-csgmc155 88 9 , , , cord-267001-csgmc155 88 10 RBD RBD NNP cord-267001-csgmc155 88 11 alone alone RB cord-267001-csgmc155 88 12 , , , cord-267001-csgmc155 88 13 and and CC cord-267001-csgmc155 88 14 PBS PBS NNP cord-267001-csgmc155 88 15 alone alone RB cord-267001-csgmc155 88 16 were be VBD cord-267001-csgmc155 88 17 included include VBN cord-267001-csgmc155 88 18 as as IN cord-267001-csgmc155 88 19 controls control NNS cord-267001-csgmc155 88 20 . . . cord-267001-csgmc155 89 1 Table table NN cord-267001-csgmc155 89 2 1 1 CD cord-267001-csgmc155 89 3 . . . cord-267001-csgmc155 90 1 Immunization immunization NN cord-267001-csgmc155 90 2 of of IN cord-267001-csgmc155 90 3 mice mouse NNS cord-267001-csgmc155 90 4 using use VBG cord-267001-csgmc155 90 5 different different JJ cord-267001-csgmc155 90 6 combinations combination NNS cord-267001-csgmc155 90 7 and/or and/or CC cord-267001-csgmc155 90 8 formulations formulation NNS cord-267001-csgmc155 90 9 of of IN cord-267001-csgmc155 90 10 the the DT cord-267001-csgmc155 90 11 vaccines vaccine NNS cord-267001-csgmc155 90 12 and and CC cord-267001-csgmc155 90 13 the the DT cord-267001-csgmc155 90 14 site site NN cord-267001-csgmc155 90 15 of of IN cord-267001-csgmc155 90 16 injection injection NN cord-267001-csgmc155 90 17 : : : cord-267001-csgmc155 91 1 C57BL/6 C57BL/6 NNP cord-267001-csgmc155 91 2 mice mouse NNS cord-267001-csgmc155 91 3 were be VBD cord-267001-csgmc155 91 4 immunized immunize VBN cord-267001-csgmc155 91 5 intramuscularly intramuscularly RB cord-267001-csgmc155 91 6 ( ( -LRB- cord-267001-csgmc155 91 7 i.m i.m NNP cord-267001-csgmc155 91 8 . . . cord-267001-csgmc155 91 9 ) ) -RRB- cord-267001-csgmc155 92 1 with with IN cord-267001-csgmc155 92 2 MERS MERS NNP cord-267001-csgmc155 92 3 - - HYPH cord-267001-csgmc155 92 4 RBD RBD NNP cord-267001-csgmc155 92 5 - - HYPH cord-267001-csgmc155 92 6 Fd Fd NNP cord-267001-csgmc155 92 7 ( ( -LRB- cord-267001-csgmc155 92 8 RBD RBD NNP cord-267001-csgmc155 92 9 ) ) -RRB- cord-267001-csgmc155 92 10 formulated formulate VBN cord-267001-csgmc155 92 11 with with IN cord-267001-csgmc155 92 12 or or CC cord-267001-csgmc155 92 13 without without IN cord-267001-csgmc155 92 14 alum alum NN cord-267001-csgmc155 92 15 and/or and/or CC cord-267001-csgmc155 92 16 rASP-1 rasp-1 NN cord-267001-csgmc155 92 17 alone alone RB cord-267001-csgmc155 92 18 or or CC cord-267001-csgmc155 92 19 together together RB cord-267001-csgmc155 92 20 in in IN cord-267001-csgmc155 92 21 different different JJ cord-267001-csgmc155 92 22 combinations combination NNS cord-267001-csgmc155 92 23 and/or and/or CC cord-267001-csgmc155 92 24 formulations formulation NNS cord-267001-csgmc155 92 25 . . . cord-267001-csgmc155 93 1 Mice mouse NNS cord-267001-csgmc155 93 2 were be VBD cord-267001-csgmc155 93 3 immunized immunize VBN cord-267001-csgmc155 93 4 twice twice RB cord-267001-csgmc155 93 5 , , , cord-267001-csgmc155 93 6 3 3 CD cord-267001-csgmc155 93 7 weeks week NNS cord-267001-csgmc155 93 8 apart apart RB cord-267001-csgmc155 93 9 according accord VBG cord-267001-csgmc155 93 10 to to IN cord-267001-csgmc155 93 11 the the DT cord-267001-csgmc155 93 12 various various JJ cord-267001-csgmc155 93 13 G1-G6 G1-G6 NNP cord-267001-csgmc155 93 14 experimental experimental JJ cord-267001-csgmc155 93 15 groups group NNS cord-267001-csgmc155 93 16 either either CC cord-267001-csgmc155 93 17 at at IN cord-267001-csgmc155 93 18 the the DT cord-267001-csgmc155 93 19 front front NN cord-267001-csgmc155 94 1 ( ( -LRB- cord-267001-csgmc155 94 2 A a NN cord-267001-csgmc155 94 3 : : : cord-267001-csgmc155 94 4 50 50 CD cord-267001-csgmc155 94 5 µL µl CD cord-267001-csgmc155 94 6 of of IN cord-267001-csgmc155 94 7 inoculum inoculum NN cord-267001-csgmc155 94 8 ) ) -RRB- cord-267001-csgmc155 95 1 and/or and/or CC cord-267001-csgmc155 96 1 the the DT cord-267001-csgmc155 96 2 back back NN cord-267001-csgmc155 97 1 ( ( -LRB- cord-267001-csgmc155 97 2 B b NN cord-267001-csgmc155 97 3 : : : cord-267001-csgmc155 97 4 50 50 CD cord-267001-csgmc155 97 5 µL µl CD cord-267001-csgmc155 97 6 of of IN cord-267001-csgmc155 97 7 inoculum inoculum NN cord-267001-csgmc155 97 8 ) ) -RRB- cord-267001-csgmc155 97 9 of of IN cord-267001-csgmc155 97 10 the the DT cord-267001-csgmc155 97 11 caudal caudal JJ cord-267001-csgmc155 97 12 thigh thigh NN cord-267001-csgmc155 97 13 muscle muscle NN cord-267001-csgmc155 97 14 in in IN cord-267001-csgmc155 97 15 each each DT cord-267001-csgmc155 97 16 hind hind NN cord-267001-csgmc155 97 17 leg leg NN cord-267001-csgmc155 97 18 . . . cord-267001-csgmc155 98 1 Injection Injection NNP cord-267001-csgmc155 98 2 Immunization Immunization NNP cord-267001-csgmc155 98 3 of of IN cord-267001-csgmc155 98 4 mice mouse NNS cord-267001-csgmc155 98 5 with with IN cord-267001-csgmc155 98 6 rASP-1 rasp-1 CD cord-267001-csgmc155 98 7 and and CC cord-267001-csgmc155 98 8 the the DT cord-267001-csgmc155 98 9 alum alum NN cord-267001-csgmc155 98 10 - - HYPH cord-267001-csgmc155 98 11 adjuvanted adjuvante VBN cord-267001-csgmc155 98 12 RBD RBD NNP cord-267001-csgmc155 98 13 vaccine vaccine NN cord-267001-csgmc155 98 14 in in IN cord-267001-csgmc155 98 15 separate separate JJ cord-267001-csgmc155 98 16 sites site NNS cord-267001-csgmc155 98 17 ( ( -LRB- cord-267001-csgmc155 98 18 G6 G6 NNP cord-267001-csgmc155 98 19 , , , cord-267001-csgmc155 98 20 Figure figure NN cord-267001-csgmc155 98 21 1 1 CD cord-267001-csgmc155 98 22 ) ) -RRB- cord-267001-csgmc155 98 23 significantly significantly RB cord-267001-csgmc155 98 24 resulted result VBD cord-267001-csgmc155 98 25 in in IN cord-267001-csgmc155 98 26 the the DT cord-267001-csgmc155 98 27 highest high JJS cord-267001-csgmc155 98 28 neutralizing neutralize VBG cord-267001-csgmc155 98 29 antibody antibody NN cord-267001-csgmc155 98 30 titers titer NNS cord-267001-csgmc155 98 31 against against IN cord-267001-csgmc155 98 32 MERS MERS NNP cord-267001-csgmc155 98 33 - - HYPH cord-267001-csgmc155 98 34 CoV cov NN cord-267001-csgmc155 98 35 infection infection NN cord-267001-csgmc155 98 36 in in IN cord-267001-csgmc155 98 37 vitro vitro FW cord-267001-csgmc155 98 38 , , , cord-267001-csgmc155 98 39 NT NT NNP cord-267001-csgmc155 98 40 50 50 CD cord-267001-csgmc155 98 41 = = SYM cord-267001-csgmc155 98 42 17,657 17,657 CD cord-267001-csgmc155 98 43 . . . cord-267001-csgmc155 99 1 It -PRON- PRP cord-267001-csgmc155 99 2 was be VBD cord-267001-csgmc155 99 3 approximately approximately RB cord-267001-csgmc155 99 4 four four CD cord-267001-csgmc155 99 5 - - RB cord-267001-csgmc155 99 6 fold fold VB cord-267001-csgmc155 99 7 higher higher RBR cord-267001-csgmc155 99 8 than than IN cord-267001-csgmc155 99 9 in in IN cord-267001-csgmc155 99 10 mice mouse NNS cord-267001-csgmc155 99 11 that that WDT cord-267001-csgmc155 99 12 were be VBD cord-267001-csgmc155 99 13 vaccinated vaccinate VBN cord-267001-csgmc155 99 14 with with IN cord-267001-csgmc155 99 15 RBD RBD NNP cord-267001-csgmc155 99 16 + + CC cord-267001-csgmc155 99 17 rASP-1 rasp-1 NN cord-267001-csgmc155 100 1 + + CC cord-267001-csgmc155 100 2 alum alum NN cord-267001-csgmc155 100 3 in in IN cord-267001-csgmc155 100 4 a a DT cord-267001-csgmc155 100 5 single single JJ cord-267001-csgmc155 100 6 inoculum inoculum NN cord-267001-csgmc155 100 7 ( ( -LRB- cord-267001-csgmc155 100 8 G5 G5 NNP cord-267001-csgmc155 100 9 − − NNP cord-267001-csgmc155 100 10 NT NT NNP cord-267001-csgmc155 100 11 50 50 CD cord-267001-csgmc155 100 12 = = SYM cord-267001-csgmc155 100 13 4453 4453 CD cord-267001-csgmc155 100 14 ; ; : cord-267001-csgmc155 100 15 Figure figure NN cord-267001-csgmc155 100 16 1 1 CD cord-267001-csgmc155 100 17 ) ) -RRB- cord-267001-csgmc155 100 18 , , , cord-267001-csgmc155 100 19 ~10-,~3- ~10-,~3- NNP cord-267001-csgmc155 100 20 , , , cord-267001-csgmc155 100 21 and and CC cord-267001-csgmc155 100 22 85-fold 85-fold CD cord-267001-csgmc155 100 23 higher high JJR cord-267001-csgmc155 100 24 when when WRB cord-267001-csgmc155 100 25 compared compare VBN cord-267001-csgmc155 100 26 to to IN cord-267001-csgmc155 100 27 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 100 28 RBD RBD NNP cord-267001-csgmc155 100 29 vaccine vaccine NN cord-267001-csgmc155 100 30 , , , cord-267001-csgmc155 100 31 alum alum NN cord-267001-csgmc155 100 32 - - HYPH cord-267001-csgmc155 100 33 adjuvanted adjuvante VBN cord-267001-csgmc155 100 34 RBD RBD NNP cord-267001-csgmc155 100 35 vaccine vaccine NN cord-267001-csgmc155 100 36 , , , cord-267001-csgmc155 100 37 and and CC cord-267001-csgmc155 100 38 RBD RBD NNP cord-267001-csgmc155 100 39 only only RB cord-267001-csgmc155 100 40 , , , cord-267001-csgmc155 100 41 respectively respectively RB cord-267001-csgmc155 100 42 ( ( -LRB- cord-267001-csgmc155 100 43 G3 G3 NNP cord-267001-csgmc155 100 44 − − NNP cord-267001-csgmc155 100 45 NT NT NNP cord-267001-csgmc155 100 46 50 50 CD cord-267001-csgmc155 100 47 = = SYM cord-267001-csgmc155 100 48 1839 1839 CD cord-267001-csgmc155 100 49 , , , cord-267001-csgmc155 100 50 G4 G4 NNP cord-267001-csgmc155 100 51 − − NNP cord-267001-csgmc155 100 52 NT NT NNP cord-267001-csgmc155 100 53 50 50 CD cord-267001-csgmc155 100 54 = = SYM cord-267001-csgmc155 100 55 6528 6528 CD cord-267001-csgmc155 100 56 , , , cord-267001-csgmc155 100 57 G2 G2 NNP cord-267001-csgmc155 100 58 − − NN cord-267001-csgmc155 100 59 NT NT NNP cord-267001-csgmc155 100 60 50 50 CD cord-267001-csgmc155 100 61 = = SYM cord-267001-csgmc155 100 62 207 207 CD cord-267001-csgmc155 100 63 , , , cord-267001-csgmc155 100 64 respectively respectively RB cord-267001-csgmc155 100 65 ; ; : cord-267001-csgmc155 100 66 Figure figure NN cord-267001-csgmc155 100 67 1 1 CD cord-267001-csgmc155 100 68 ) ) -RRB- cord-267001-csgmc155 100 69 . . . cord-267001-csgmc155 101 1 It -PRON- PRP cord-267001-csgmc155 101 2 appears appear VBZ cord-267001-csgmc155 101 3 that that IN cord-267001-csgmc155 101 4 this this DT cord-267001-csgmc155 101 5 unique unique JJ cord-267001-csgmc155 101 6 rASP-1 rasp-1 NN cord-267001-csgmc155 101 7 and and CC cord-267001-csgmc155 101 8 alum alum NN cord-267001-csgmc155 101 9 combinatorial combinatorial JJ cord-267001-csgmc155 101 10 adjuvants adjuvant NNS cord-267001-csgmc155 101 11 promoted promote VBD cord-267001-csgmc155 101 12 synergy synergy NN cord-267001-csgmc155 101 13 in in IN cord-267001-csgmc155 101 14 the the DT cord-267001-csgmc155 101 15 functional functional JJ cord-267001-csgmc155 101 16 humoral humoral JJ cord-267001-csgmc155 101 17 response response NN cord-267001-csgmc155 101 18 produced produce VBN cord-267001-csgmc155 101 19 vs. vs. IN cord-267001-csgmc155 101 20 the the DT cord-267001-csgmc155 101 21 vaccines vaccine NNS cord-267001-csgmc155 101 22 that that WDT cord-267001-csgmc155 101 23 utilized utilize VBD cord-267001-csgmc155 101 24 the the DT cord-267001-csgmc155 101 25 other other JJ cord-267001-csgmc155 101 26 formulations formulation NNS cord-267001-csgmc155 101 27 and/or and/or CC cord-267001-csgmc155 101 28 regimens regimen NNS cord-267001-csgmc155 101 29 , , , cord-267001-csgmc155 101 30 including include VBG cord-267001-csgmc155 101 31 the the DT cord-267001-csgmc155 101 32 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 101 33 RBD RBD NNP cord-267001-csgmc155 101 34 vaccine vaccine NN cord-267001-csgmc155 101 35 . . . cord-267001-csgmc155 101 36 ) ) -RRB- cord-267001-csgmc155 101 37 . . . cord-267001-csgmc155 102 1 It -PRON- PRP cord-267001-csgmc155 102 2 appears appear VBZ cord-267001-csgmc155 102 3 that that IN cord-267001-csgmc155 102 4 this this DT cord-267001-csgmc155 102 5 unique unique JJ cord-267001-csgmc155 102 6 rASP-1 rasp-1 NN cord-267001-csgmc155 102 7 and and CC cord-267001-csgmc155 102 8 alum alum NN cord-267001-csgmc155 102 9 combinatorial combinatorial JJ cord-267001-csgmc155 102 10 adjuvants adjuvant NNS cord-267001-csgmc155 102 11 promoted promote VBD cord-267001-csgmc155 102 12 synergy synergy NN cord-267001-csgmc155 102 13 in in IN cord-267001-csgmc155 102 14 the the DT cord-267001-csgmc155 102 15 functional functional JJ cord-267001-csgmc155 102 16 humoral humoral JJ cord-267001-csgmc155 102 17 response response NN cord-267001-csgmc155 102 18 produced produce VBN cord-267001-csgmc155 102 19 vs. vs. IN cord-267001-csgmc155 102 20 the the DT cord-267001-csgmc155 102 21 vaccines vaccine NNS cord-267001-csgmc155 102 22 that that WDT cord-267001-csgmc155 102 23 utilized utilize VBD cord-267001-csgmc155 102 24 the the DT cord-267001-csgmc155 102 25 other other JJ cord-267001-csgmc155 102 26 formulations formulation NNS cord-267001-csgmc155 102 27 and/or and/or CC cord-267001-csgmc155 102 28 regimens regimen NNS cord-267001-csgmc155 102 29 , , , cord-267001-csgmc155 102 30 including include VBG cord-267001-csgmc155 102 31 the the DT cord-267001-csgmc155 102 32 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 102 33 RBD RBD NNP cord-267001-csgmc155 102 34 vaccine vaccine NN cord-267001-csgmc155 102 35 . . . cord-267001-csgmc155 103 1 ( ( -LRB- cord-267001-csgmc155 103 2 Table table NN cord-267001-csgmc155 103 3 1 1 CD cord-267001-csgmc155 103 4 and and CC cord-267001-csgmc155 103 5 X x NN cord-267001-csgmc155 103 6 - - NN cord-267001-csgmc155 103 7 axis axis NN cord-267001-csgmc155 103 8 legend legend NN cord-267001-csgmc155 103 9 ) ) -RRB- cord-267001-csgmc155 103 10 . . . cord-267001-csgmc155 104 1 Sera Sera NNP cord-267001-csgmc155 104 2 samples sample NNS cord-267001-csgmc155 104 3 were be VBD cord-267001-csgmc155 104 4 collected collect VBN cord-267001-csgmc155 104 5 7 7 CD cord-267001-csgmc155 104 6 days day NNS cord-267001-csgmc155 104 7 post-2nd post-2nd JJ cord-267001-csgmc155 104 8 immunization immunization NN cord-267001-csgmc155 104 9 and and CC cord-267001-csgmc155 104 10 analyzed analyze VBN cord-267001-csgmc155 104 11 for for IN cord-267001-csgmc155 104 12 neutralization neutralization NN cord-267001-csgmc155 104 13 of of IN cord-267001-csgmc155 104 14 the the DT cord-267001-csgmc155 104 15 pseudotyped pseudotyped NNP cord-267001-csgmc155 104 16 MERS- MERS- NNP cord-267001-csgmc155 105 1 CoV. CoV. NNP cord-267001-csgmc155 106 1 The the DT cord-267001-csgmc155 106 2 data data NN cord-267001-csgmc155 106 3 represents represent VBZ cord-267001-csgmc155 106 4 the the DT cord-267001-csgmc155 106 5 mean mean JJ cord-267001-csgmc155 106 6 and and CC cord-267001-csgmc155 106 7 standard standard JJ cord-267001-csgmc155 106 8 error error NN cord-267001-csgmc155 106 9 ( ( -LRB- cord-267001-csgmc155 106 10 SEM SEM NNP cord-267001-csgmc155 106 11 ) ) -RRB- cord-267001-csgmc155 106 12 of of IN cord-267001-csgmc155 106 13 NT50 NT50 NNP cord-267001-csgmc155 106 14 titers titer NNS cord-267001-csgmc155 106 15 from from IN cord-267001-csgmc155 106 16 at at RB cord-267001-csgmc155 106 17 least least RBS cord-267001-csgmc155 106 18 two two CD cord-267001-csgmc155 106 19 independent independent JJ cord-267001-csgmc155 106 20 experiments experiment NNS cord-267001-csgmc155 106 21 with with IN cord-267001-csgmc155 106 22 3 3 CD cord-267001-csgmc155 106 23 to to TO cord-267001-csgmc155 106 24 5 5 CD cord-267001-csgmc155 106 25 mice mouse NNS cord-267001-csgmc155 106 26 per per IN cord-267001-csgmc155 106 27 group group NN cord-267001-csgmc155 106 28 . . . cord-267001-csgmc155 107 1 " " `` cord-267001-csgmc155 107 2 + + CC cord-267001-csgmc155 107 3 " " `` cord-267001-csgmc155 107 4 indicates indicate VBZ cord-267001-csgmc155 107 5 the the DT cord-267001-csgmc155 107 6 presence presence NN cord-267001-csgmc155 107 7 and and CC cord-267001-csgmc155 107 8 " " `` cord-267001-csgmc155 107 9 − − NNP cord-267001-csgmc155 107 10 " " '' cord-267001-csgmc155 107 11 indicates indicate VBZ cord-267001-csgmc155 107 12 the the DT cord-267001-csgmc155 107 13 absence absence NN cord-267001-csgmc155 107 14 of of IN cord-267001-csgmc155 107 15 the the DT cord-267001-csgmc155 107 16 protein protein NN cord-267001-csgmc155 107 17 or or CC cord-267001-csgmc155 107 18 adjuvants adjuvant NNS cord-267001-csgmc155 107 19 in in IN cord-267001-csgmc155 107 20 the the DT cord-267001-csgmc155 107 21 formulation formulation NN cord-267001-csgmc155 107 22 . . . cord-267001-csgmc155 108 1 Statistics statistic NNS cord-267001-csgmc155 108 2 was be VBD cord-267001-csgmc155 108 3 performed perform VBN cord-267001-csgmc155 108 4 using use VBG cord-267001-csgmc155 108 5 one one CD cord-267001-csgmc155 108 6 - - HYPH cord-267001-csgmc155 108 7 way way NN cord-267001-csgmc155 108 8 ANOVA anova NN cord-267001-csgmc155 108 9 with with IN cord-267001-csgmc155 108 10 Tukey Tukey NNP cord-267001-csgmc155 108 11 's 's POS cord-267001-csgmc155 108 12 multiple multiple JJ cord-267001-csgmc155 108 13 comparison comparison NN cord-267001-csgmc155 108 14 . . . cord-267001-csgmc155 109 1 p p NN cord-267001-csgmc155 109 2 < < XX cord-267001-csgmc155 109 3 0.001 0.001 CD cord-267001-csgmc155 109 4 : : : cord-267001-csgmc155 110 1 * * NFP cord-267001-csgmc155 110 2 * * NFP cord-267001-csgmc155 110 3 * * NFP cord-267001-csgmc155 110 4 , , , cord-267001-csgmc155 110 5 p p NN cord-267001-csgmc155 110 6 < < XX cord-267001-csgmc155 110 7 0.0001 0.0001 CD cord-267001-csgmc155 110 8 : : : cord-267001-csgmc155 111 1 * * NFP cord-267001-csgmc155 111 2 * * NFP cord-267001-csgmc155 111 3 * * NFP cord-267001-csgmc155 111 4 * * NFP cord-267001-csgmc155 111 5 , , , cord-267001-csgmc155 111 6 ND ND NNP cord-267001-csgmc155 111 7 : : : cord-267001-csgmc155 111 8 not not RB cord-267001-csgmc155 111 9 detectable detectable JJ cord-267001-csgmc155 111 10 . . . cord-267001-csgmc155 112 1 When when WRB cord-267001-csgmc155 112 2 the the DT cord-267001-csgmc155 112 3 total total JJ cord-267001-csgmc155 112 4 IgG igg NN cord-267001-csgmc155 112 5 response response NN cord-267001-csgmc155 112 6 to to IN cord-267001-csgmc155 112 7 the the DT cord-267001-csgmc155 112 8 MERS MERS NNP cord-267001-csgmc155 112 9 - - HYPH cord-267001-csgmc155 112 10 RBD RBD NNP cord-267001-csgmc155 112 11 antigen antigen NN cord-267001-csgmc155 112 12 was be VBD cord-267001-csgmc155 112 13 studied study VBN cord-267001-csgmc155 112 14 using use VBG cord-267001-csgmc155 112 15 the the DT cord-267001-csgmc155 112 16 MERS MERS NNP cord-267001-csgmc155 112 17 - - HYPH cord-267001-csgmc155 112 18 CoV CoV NNP cord-267001-csgmc155 112 19 S1 S1 NNP cord-267001-csgmc155 112 20 protein protein NN cord-267001-csgmc155 112 21 as as IN cord-267001-csgmc155 112 22 the the DT cord-267001-csgmc155 112 23 target target NN cord-267001-csgmc155 112 24 protein protein NN cord-267001-csgmc155 112 25 , , , cord-267001-csgmc155 112 26 we -PRON- PRP cord-267001-csgmc155 112 27 found find VBD cord-267001-csgmc155 112 28 that that IN cord-267001-csgmc155 112 29 although although IN cord-267001-csgmc155 112 30 the the DT cord-267001-csgmc155 112 31 RBD RBD NNP cord-267001-csgmc155 112 32 - - HYPH cord-267001-csgmc155 112 33 specific specific JJ cord-267001-csgmc155 112 34 total total JJ cord-267001-csgmc155 112 35 IgG igg NN cord-267001-csgmc155 112 36 antibody antibody NN cord-267001-csgmc155 112 37 titers titer NNS cord-267001-csgmc155 112 38 were be VBD cord-267001-csgmc155 112 39 ~8 ~8 CD cord-267001-csgmc155 112 40 times time NNS cord-267001-csgmc155 112 41 higher high JJR cord-267001-csgmc155 112 42 in in IN cord-267001-csgmc155 112 43 mice mouse NNS cord-267001-csgmc155 112 44 that that WDT cord-267001-csgmc155 112 45 were be VBD cord-267001-csgmc155 112 46 vaccinated vaccinate VBN cord-267001-csgmc155 112 47 by by IN cord-267001-csgmc155 112 48 co co NN cord-267001-csgmc155 112 49 - - JJ cord-267001-csgmc155 112 50 administrating administrating JJ cord-267001-csgmc155 112 51 rASP-1 rasp-1 CD cord-267001-csgmc155 112 52 and and CC cord-267001-csgmc155 112 53 the the DT cord-267001-csgmc155 112 54 alum alum NN cord-267001-csgmc155 112 55 - - HYPH cord-267001-csgmc155 112 56 adjuvanted adjuvante VBN cord-267001-csgmc155 112 57 RBD RBD NNP cord-267001-csgmc155 112 58 vaccine vaccine NN cord-267001-csgmc155 112 59 in in IN cord-267001-csgmc155 112 60 separate separate JJ cord-267001-csgmc155 112 61 sites site NNS cord-267001-csgmc155 112 62 ( ( -LRB- cord-267001-csgmc155 112 63 G6 G6 NNP cord-267001-csgmc155 112 64 - - HYPH cord-267001-csgmc155 112 65 142,525 142,525 CD cord-267001-csgmc155 112 66 end end NN cord-267001-csgmc155 112 67 point point NN cord-267001-csgmc155 112 68 titer titer NN cord-267001-csgmc155 112 69 ) ) -RRB- cord-267001-csgmc155 112 70 , , , cord-267001-csgmc155 112 71 they -PRON- PRP cord-267001-csgmc155 112 72 were be VBD cord-267001-csgmc155 112 73 not not RB cord-267001-csgmc155 112 74 significantly significantly RB cord-267001-csgmc155 112 75 different different JJ cord-267001-csgmc155 112 76 from from IN cord-267001-csgmc155 112 77 those those DT cord-267001-csgmc155 112 78 elicited elicit VBN cord-267001-csgmc155 112 79 by by IN cord-267001-csgmc155 112 80 immunization immunization NN cord-267001-csgmc155 112 81 with with IN cord-267001-csgmc155 112 82 RBD RBD NNP cord-267001-csgmc155 112 83 + + CC cord-267001-csgmc155 112 84 rASP-1 rasp-1 NN cord-267001-csgmc155 112 85 + + CC cord-267001-csgmc155 112 86 alum alum NN cord-267001-csgmc155 112 87 administered administer VBN cord-267001-csgmc155 112 88 in in IN cord-267001-csgmc155 112 89 a a DT cord-267001-csgmc155 112 90 single single JJ cord-267001-csgmc155 112 91 inoculum inoculum NN cord-267001-csgmc155 112 92 ( ( -LRB- cord-267001-csgmc155 112 93 G5 G5 NNP cord-267001-csgmc155 112 94 - - HYPH cord-267001-csgmc155 112 95 18,149 18,149 CD cord-267001-csgmc155 112 96 end end NN cord-267001-csgmc155 112 97 point point NN cord-267001-csgmc155 112 98 titer titer NN cord-267001-csgmc155 112 99 ) ) -RRB- cord-267001-csgmc155 112 100 , , , cord-267001-csgmc155 112 101 or or CC cord-267001-csgmc155 112 102 with with IN cord-267001-csgmc155 112 103 the the DT cord-267001-csgmc155 112 104 alum alum NN cord-267001-csgmc155 112 105 - - HYPH cord-267001-csgmc155 112 106 adjuvanted adjuvante VBN cord-267001-csgmc155 112 107 RBD RBD NNP cord-267001-csgmc155 112 108 vaccine vaccine NN cord-267001-csgmc155 112 109 ( ( -LRB- cord-267001-csgmc155 112 110 G4 G4 NNP cord-267001-csgmc155 112 111 - - HYPH cord-267001-csgmc155 112 112 53,104 53,104 CD cord-267001-csgmc155 112 113 end end NN cord-267001-csgmc155 112 114 point point NN cord-267001-csgmc155 112 115 titer titer NN cord-267001-csgmc155 112 116 ; ; : cord-267001-csgmc155 112 117 Figure figure VB cord-267001-csgmc155 112 118 _SP cord-267001-csgmc155 112 119 S1A s1a NN cord-267001-csgmc155 112 120 ) ) -RRB- cord-267001-csgmc155 112 121 . . . cord-267001-csgmc155 113 1 Nevertheless nevertheless RB cord-267001-csgmc155 113 2 , , , cord-267001-csgmc155 113 3 the the DT cord-267001-csgmc155 113 4 co co NN cord-267001-csgmc155 113 5 - - NN cord-267001-csgmc155 113 6 administration administration NN cord-267001-csgmc155 113 7 of of IN cord-267001-csgmc155 113 8 rASP-1 rASP-1 NNP cord-267001-csgmc155 113 9 and and CC cord-267001-csgmc155 113 10 the the DT cord-267001-csgmc155 113 11 alum alum NN cord-267001-csgmc155 113 12 - - HYPH cord-267001-csgmc155 113 13 adjuvanted adjuvante VBN cord-267001-csgmc155 113 14 RBD RBD NNP cord-267001-csgmc155 113 15 vaccine vaccine NN cord-267001-csgmc155 113 16 in in IN cord-267001-csgmc155 113 17 separate separate JJ cord-267001-csgmc155 113 18 sites site NNS cord-267001-csgmc155 113 19 significantly significantly RB cord-267001-csgmc155 113 20 increased increase VBD cord-267001-csgmc155 113 21 the the DT cord-267001-csgmc155 113 22 RBD RBD NNP cord-267001-csgmc155 113 23 - - HYPH cord-267001-csgmc155 113 24 specific specific JJ cord-267001-csgmc155 113 25 total total JJ cord-267001-csgmc155 113 26 IgG igg NN cord-267001-csgmc155 113 27 antibody antibody NN cord-267001-csgmc155 113 28 titers titer NNS cord-267001-csgmc155 113 29 by by IN cord-267001-csgmc155 113 30 ~20-fold ~20-fold NN cord-267001-csgmc155 113 31 compared compare VBN cord-267001-csgmc155 113 32 to to IN cord-267001-csgmc155 113 33 rASP-1-adjuvanted rASP-1-adjuvanted NNP cord-267001-csgmc155 113 34 MERS MERS NNP cord-267001-csgmc155 113 35 - - HYPH cord-267001-csgmc155 113 36 RBD RBD NNP cord-267001-csgmc155 113 37 vaccine vaccine NN cord-267001-csgmc155 113 38 or or CC cord-267001-csgmc155 113 39 ~160-fold ~160-fold NNP cord-267001-csgmc155 113 40 compared compare VBN cord-267001-csgmc155 113 41 to to IN cord-267001-csgmc155 113 42 the the DT cord-267001-csgmc155 113 43 RBD RBD NNP cord-267001-csgmc155 113 44 vaccine vaccine NN cord-267001-csgmc155 113 45 alone alone RB cord-267001-csgmc155 113 46 ( ( -LRB- cord-267001-csgmc155 113 47 G6 G6 NNP cord-267001-csgmc155 113 48 - - HYPH cord-267001-csgmc155 113 49 142,525 142,525 CD cord-267001-csgmc155 113 50 , , , cord-267001-csgmc155 113 51 G3 G3 NNP cord-267001-csgmc155 113 52 - - HYPH cord-267001-csgmc155 113 53 6700 6700 CD cord-267001-csgmc155 113 54 and and CC cord-267001-csgmc155 113 55 G2 G2 NNP cord-267001-csgmc155 113 56 - - HYPH cord-267001-csgmc155 113 57 872 872 CD cord-267001-csgmc155 113 58 end end NN cord-267001-csgmc155 113 59 point point NN cord-267001-csgmc155 113 60 titers titer NNS cord-267001-csgmc155 113 61 respectively respectively RB cord-267001-csgmc155 113 62 ; ; : cord-267001-csgmc155 113 63 Figure figure NN cord-267001-csgmc155 113 64 S1A s1a NN cord-267001-csgmc155 113 65 ) ) -RRB- cord-267001-csgmc155 113 66 ; ; : cord-267001-csgmc155 113 67 clearly clearly RB cord-267001-csgmc155 113 68 showing show VBG cord-267001-csgmc155 113 69 that that IN cord-267001-csgmc155 113 70 immunization immunization NN cord-267001-csgmc155 113 71 using use VBG cord-267001-csgmc155 113 72 the the DT cord-267001-csgmc155 113 73 unique unique JJ cord-267001-csgmc155 113 74 rASP-1 rasp-1 NN cord-267001-csgmc155 113 75 and and CC cord-267001-csgmc155 113 76 alum alum NN cord-267001-csgmc155 113 77 combinational combinational JJ cord-267001-csgmc155 113 78 adjuvants adjuvant NNS cord-267001-csgmc155 113 79 had have VBD cord-267001-csgmc155 113 80 a a DT cord-267001-csgmc155 113 81 beneficiary beneficiary NN cord-267001-csgmc155 113 82 effect effect NN cord-267001-csgmc155 113 83 in in IN cord-267001-csgmc155 113 84 comparison comparison NN cord-267001-csgmc155 113 85 to to IN cord-267001-csgmc155 113 86 the the DT cord-267001-csgmc155 113 87 rASP-1 rASP-1 VBN cord-267001-csgmc155 113 88 ( ( -LRB- cord-267001-csgmc155 113 89 ~20 ~20 NFP cord-267001-csgmc155 113 90 fold fold VB cord-267001-csgmc155 113 91 ) ) -RRB- cord-267001-csgmc155 113 92 or or CC cord-267001-csgmc155 113 93 the the DT cord-267001-csgmc155 113 94 alum alum NN cord-267001-csgmc155 113 95 ( ( -LRB- cord-267001-csgmc155 113 96 ~3 ~3 NFP cord-267001-csgmc155 113 97 fold fold VB cord-267001-csgmc155 113 98 ) ) -RRB- cord-267001-csgmc155 113 99 adjuvanted adjuvante VBN cord-267001-csgmc155 113 100 vaccines vaccine NNS cord-267001-csgmc155 113 101 . . . cord-267001-csgmc155 114 1 To to TO cord-267001-csgmc155 114 2 elucidate elucidate VB cord-267001-csgmc155 114 3 the the DT cord-267001-csgmc155 114 4 IgG igg NN cord-267001-csgmc155 114 5 subtypes subtype NNS cord-267001-csgmc155 114 6 induced induce VBN cord-267001-csgmc155 114 7 in in IN cord-267001-csgmc155 114 8 the the DT cord-267001-csgmc155 114 9 different different JJ cord-267001-csgmc155 114 10 immunization immunization NN cord-267001-csgmc155 114 11 groups group NNS cord-267001-csgmc155 114 12 , , , cord-267001-csgmc155 114 13 we -PRON- PRP cord-267001-csgmc155 114 14 also also RB cord-267001-csgmc155 114 15 analyzed analyze VBD cord-267001-csgmc155 114 16 the the DT cord-267001-csgmc155 114 17 RBD RBD NNP cord-267001-csgmc155 114 18 - - HYPH cord-267001-csgmc155 114 19 specific specific JJ cord-267001-csgmc155 114 20 IgG1 igg1 NN cord-267001-csgmc155 114 21 and and CC cord-267001-csgmc155 114 22 IgG2c IgG2c NNP cord-267001-csgmc155 114 23 antibody antibody NN cord-267001-csgmc155 114 24 titers titer NNS cord-267001-csgmc155 114 25 . . . cord-267001-csgmc155 115 1 We -PRON- PRP cord-267001-csgmc155 115 2 observed observe VBD cord-267001-csgmc155 115 3 that that IN cord-267001-csgmc155 115 4 the the DT cord-267001-csgmc155 115 5 highest high JJS cord-267001-csgmc155 115 6 titer titer NN cord-267001-csgmc155 115 7 of of IN cord-267001-csgmc155 115 8 IgG1 IgG1 NNP cord-267001-csgmc155 115 9 antibodies antibody NNS cord-267001-csgmc155 115 10 was be VBD cord-267001-csgmc155 115 11 induced induce VBN cord-267001-csgmc155 115 12 when when WRB cord-267001-csgmc155 115 13 the the DT cord-267001-csgmc155 115 14 RBD RBD NNP cord-267001-csgmc155 115 15 vaccine vaccine NN cord-267001-csgmc155 115 16 was be VBD cord-267001-csgmc155 115 17 formulated formulate VBN cord-267001-csgmc155 115 18 with with IN cord-267001-csgmc155 115 19 alum alum NN cord-267001-csgmc155 115 20 alone alone RB cord-267001-csgmc155 115 21 or or CC cord-267001-csgmc155 115 22 with with IN cord-267001-csgmc155 115 23 rASP-1 rasp-1 ADD cord-267001-csgmc155 116 1 + + CC cord-267001-csgmc155 117 1 alum alum NN cord-267001-csgmc155 117 2 in in IN cord-267001-csgmc155 117 3 one one CD cord-267001-csgmc155 117 4 inoculum inoculum NN cord-267001-csgmc155 118 1 ( ( -LRB- cord-267001-csgmc155 118 2 G4 G4 NNP cord-267001-csgmc155 118 3 - - HYPH cord-267001-csgmc155 118 4 250,951 250,951 CD cord-267001-csgmc155 118 5 and and CC cord-267001-csgmc155 119 1 G5 G5 NNP cord-267001-csgmc155 119 2 - - HYPH cord-267001-csgmc155 119 3 369,000 369,000 CD cord-267001-csgmc155 119 4 end end NN cord-267001-csgmc155 119 5 point point NN cord-267001-csgmc155 119 6 titers titer NNS cord-267001-csgmc155 119 7 respectively respectively RB cord-267001-csgmc155 119 8 ; ; : cord-267001-csgmc155 119 9 Figure figure NN cord-267001-csgmc155 119 10 S1B s1b NN cord-267001-csgmc155 119 11 ) ) -RRB- cord-267001-csgmc155 119 12 , , , cord-267001-csgmc155 119 13 with with IN cord-267001-csgmc155 119 14 the the DT cord-267001-csgmc155 119 15 titers titer NNS cord-267001-csgmc155 119 16 being be VBG cord-267001-csgmc155 119 17 ( ( -LRB- cord-267001-csgmc155 119 18 Table table NN cord-267001-csgmc155 119 19 1 1 CD cord-267001-csgmc155 119 20 and and CC cord-267001-csgmc155 119 21 X x NN cord-267001-csgmc155 119 22 - - NN cord-267001-csgmc155 119 23 axis axis NN cord-267001-csgmc155 119 24 legend legend NN cord-267001-csgmc155 119 25 ) ) -RRB- cord-267001-csgmc155 119 26 . . . cord-267001-csgmc155 120 1 Sera Sera NNP cord-267001-csgmc155 120 2 samples sample NNS cord-267001-csgmc155 120 3 were be VBD cord-267001-csgmc155 120 4 collected collect VBN cord-267001-csgmc155 120 5 7 7 CD cord-267001-csgmc155 120 6 days day NNS cord-267001-csgmc155 120 7 post-2nd post-2nd JJ cord-267001-csgmc155 120 8 immunization immunization NN cord-267001-csgmc155 120 9 and and CC cord-267001-csgmc155 120 10 analyzed analyze VBN cord-267001-csgmc155 120 11 for for IN cord-267001-csgmc155 120 12 neutralization neutralization NN cord-267001-csgmc155 120 13 of of IN cord-267001-csgmc155 120 14 the the DT cord-267001-csgmc155 120 15 pseudotyped pseudotyped NNP cord-267001-csgmc155 120 16 MERS- MERS- NNP cord-267001-csgmc155 121 1 CoV. CoV. NNP cord-267001-csgmc155 122 1 The the DT cord-267001-csgmc155 122 2 data data NN cord-267001-csgmc155 122 3 represents represent VBZ cord-267001-csgmc155 122 4 the the DT cord-267001-csgmc155 122 5 mean mean JJ cord-267001-csgmc155 122 6 and and CC cord-267001-csgmc155 122 7 standard standard JJ cord-267001-csgmc155 122 8 error error NN cord-267001-csgmc155 122 9 ( ( -LRB- cord-267001-csgmc155 122 10 SEM SEM NNP cord-267001-csgmc155 122 11 ) ) -RRB- cord-267001-csgmc155 122 12 of of IN cord-267001-csgmc155 122 13 NT NT NNP cord-267001-csgmc155 122 14 50 50 CD cord-267001-csgmc155 122 15 titers titer NNS cord-267001-csgmc155 122 16 from from IN cord-267001-csgmc155 122 17 at at RB cord-267001-csgmc155 122 18 least least RBS cord-267001-csgmc155 122 19 two two CD cord-267001-csgmc155 122 20 independent independent JJ cord-267001-csgmc155 122 21 experiments experiment NNS cord-267001-csgmc155 122 22 with with IN cord-267001-csgmc155 122 23 3 3 CD cord-267001-csgmc155 122 24 to to TO cord-267001-csgmc155 122 25 5 5 CD cord-267001-csgmc155 122 26 mice mouse NNS cord-267001-csgmc155 122 27 per per IN cord-267001-csgmc155 122 28 group group NN cord-267001-csgmc155 122 29 . . . cord-267001-csgmc155 123 1 " " `` cord-267001-csgmc155 123 2 + + CC cord-267001-csgmc155 123 3 " " `` cord-267001-csgmc155 123 4 indicates indicate VBZ cord-267001-csgmc155 123 5 the the DT cord-267001-csgmc155 123 6 presence presence NN cord-267001-csgmc155 123 7 and and CC cord-267001-csgmc155 123 8 " " `` cord-267001-csgmc155 123 9 − − NNP cord-267001-csgmc155 123 10 " " '' cord-267001-csgmc155 123 11 indicates indicate VBZ cord-267001-csgmc155 123 12 the the DT cord-267001-csgmc155 123 13 absence absence NN cord-267001-csgmc155 123 14 of of IN cord-267001-csgmc155 123 15 the the DT cord-267001-csgmc155 123 16 protein protein NN cord-267001-csgmc155 123 17 or or CC cord-267001-csgmc155 123 18 adjuvants adjuvant NNS cord-267001-csgmc155 123 19 in in IN cord-267001-csgmc155 123 20 the the DT cord-267001-csgmc155 123 21 formulation formulation NN cord-267001-csgmc155 123 22 . . . cord-267001-csgmc155 124 1 Statistics statistic NNS cord-267001-csgmc155 124 2 was be VBD cord-267001-csgmc155 124 3 performed perform VBN cord-267001-csgmc155 124 4 using use VBG cord-267001-csgmc155 124 5 one one CD cord-267001-csgmc155 124 6 - - HYPH cord-267001-csgmc155 124 7 way way NN cord-267001-csgmc155 124 8 ANOVA anova NN cord-267001-csgmc155 124 9 with with IN cord-267001-csgmc155 124 10 Tukey Tukey NNP cord-267001-csgmc155 124 11 's 's POS cord-267001-csgmc155 124 12 multiple multiple JJ cord-267001-csgmc155 124 13 comparison comparison NN cord-267001-csgmc155 124 14 . . . cord-267001-csgmc155 125 1 p p NN cord-267001-csgmc155 125 2 < < XX cord-267001-csgmc155 125 3 0.001 0.001 CD cord-267001-csgmc155 125 4 : : : cord-267001-csgmc155 126 1 * * NFP cord-267001-csgmc155 126 2 * * NFP cord-267001-csgmc155 126 3 * * NFP cord-267001-csgmc155 126 4 , , , cord-267001-csgmc155 126 5 p p NN cord-267001-csgmc155 126 6 < < XX cord-267001-csgmc155 126 7 0.0001 0.0001 CD cord-267001-csgmc155 126 8 : : : cord-267001-csgmc155 127 1 * * NFP cord-267001-csgmc155 127 2 * * NFP cord-267001-csgmc155 127 3 * * NFP cord-267001-csgmc155 127 4 * * NFP cord-267001-csgmc155 127 5 , , , cord-267001-csgmc155 127 6 ND ND NNP cord-267001-csgmc155 127 7 : : : cord-267001-csgmc155 127 8 not not RB cord-267001-csgmc155 127 9 detectable detectable JJ cord-267001-csgmc155 127 10 . . . cord-267001-csgmc155 128 1 When when WRB cord-267001-csgmc155 128 2 the the DT cord-267001-csgmc155 128 3 total total JJ cord-267001-csgmc155 128 4 IgG igg NN cord-267001-csgmc155 128 5 response response NN cord-267001-csgmc155 128 6 to to IN cord-267001-csgmc155 128 7 the the DT cord-267001-csgmc155 128 8 MERS MERS NNP cord-267001-csgmc155 128 9 - - HYPH cord-267001-csgmc155 128 10 RBD RBD NNP cord-267001-csgmc155 128 11 antigen antigen NN cord-267001-csgmc155 128 12 was be VBD cord-267001-csgmc155 128 13 studied study VBN cord-267001-csgmc155 128 14 using use VBG cord-267001-csgmc155 128 15 the the DT cord-267001-csgmc155 128 16 MERS MERS NNP cord-267001-csgmc155 128 17 - - HYPH cord-267001-csgmc155 128 18 CoV CoV NNP cord-267001-csgmc155 128 19 S1 S1 NNP cord-267001-csgmc155 128 20 protein protein NN cord-267001-csgmc155 128 21 as as IN cord-267001-csgmc155 128 22 the the DT cord-267001-csgmc155 128 23 target target NN cord-267001-csgmc155 128 24 protein protein NN cord-267001-csgmc155 128 25 , , , cord-267001-csgmc155 128 26 we -PRON- PRP cord-267001-csgmc155 128 27 found find VBD cord-267001-csgmc155 128 28 that that IN cord-267001-csgmc155 128 29 although although IN cord-267001-csgmc155 128 30 the the DT cord-267001-csgmc155 128 31 RBD RBD NNP cord-267001-csgmc155 128 32 - - HYPH cord-267001-csgmc155 128 33 specific specific JJ cord-267001-csgmc155 128 34 total total JJ cord-267001-csgmc155 128 35 IgG igg NN cord-267001-csgmc155 128 36 antibody antibody NN cord-267001-csgmc155 128 37 titers titer NNS cord-267001-csgmc155 128 38 werẽ werẽ NNP cord-267001-csgmc155 128 39 8 8 CD cord-267001-csgmc155 128 40 times time NNS cord-267001-csgmc155 128 41 higher high JJR cord-267001-csgmc155 128 42 in in IN cord-267001-csgmc155 128 43 mice mouse NNS cord-267001-csgmc155 128 44 that that WDT cord-267001-csgmc155 128 45 were be VBD cord-267001-csgmc155 128 46 vaccinated vaccinate VBN cord-267001-csgmc155 128 47 by by IN cord-267001-csgmc155 128 48 co co NN cord-267001-csgmc155 128 49 - - JJ cord-267001-csgmc155 128 50 administrating administrating JJ cord-267001-csgmc155 128 51 rASP-1 rasp-1 CD cord-267001-csgmc155 128 52 and and CC cord-267001-csgmc155 128 53 the the DT cord-267001-csgmc155 128 54 alum alum NN cord-267001-csgmc155 128 55 - - HYPH cord-267001-csgmc155 128 56 adjuvanted adjuvante VBN cord-267001-csgmc155 128 57 RBD RBD NNP cord-267001-csgmc155 128 58 vaccine vaccine NN cord-267001-csgmc155 128 59 in in IN cord-267001-csgmc155 128 60 separate separate JJ cord-267001-csgmc155 128 61 sites site NNS cord-267001-csgmc155 128 62 ( ( -LRB- cord-267001-csgmc155 128 63 G6 G6 NNP cord-267001-csgmc155 128 64 - - HYPH cord-267001-csgmc155 128 65 142,525 142,525 CD cord-267001-csgmc155 128 66 end end NN cord-267001-csgmc155 128 67 point point NN cord-267001-csgmc155 128 68 titer titer NN cord-267001-csgmc155 128 69 ) ) -RRB- cord-267001-csgmc155 128 70 , , , cord-267001-csgmc155 128 71 they -PRON- PRP cord-267001-csgmc155 128 72 were be VBD cord-267001-csgmc155 128 73 not not RB cord-267001-csgmc155 128 74 significantly significantly RB cord-267001-csgmc155 128 75 different different JJ cord-267001-csgmc155 128 76 from from IN cord-267001-csgmc155 128 77 those those DT cord-267001-csgmc155 128 78 elicited elicit VBN cord-267001-csgmc155 128 79 by by IN cord-267001-csgmc155 128 80 immunization immunization NN cord-267001-csgmc155 128 81 with with IN cord-267001-csgmc155 128 82 RBD RBD NNP cord-267001-csgmc155 128 83 + + CC cord-267001-csgmc155 128 84 rASP-1 rasp-1 NN cord-267001-csgmc155 128 85 + + CC cord-267001-csgmc155 128 86 alum alum NN cord-267001-csgmc155 128 87 administered administer VBN cord-267001-csgmc155 128 88 in in IN cord-267001-csgmc155 128 89 a a DT cord-267001-csgmc155 128 90 single single JJ cord-267001-csgmc155 128 91 inoculum inoculum NN cord-267001-csgmc155 128 92 ( ( -LRB- cord-267001-csgmc155 128 93 G5 G5 NNP cord-267001-csgmc155 128 94 - - HYPH cord-267001-csgmc155 128 95 18,149 18,149 CD cord-267001-csgmc155 128 96 end end NN cord-267001-csgmc155 128 97 point point NN cord-267001-csgmc155 128 98 titer titer NN cord-267001-csgmc155 128 99 ) ) -RRB- cord-267001-csgmc155 128 100 , , , cord-267001-csgmc155 128 101 or or CC cord-267001-csgmc155 128 102 with with IN cord-267001-csgmc155 128 103 the the DT cord-267001-csgmc155 128 104 alum alum NN cord-267001-csgmc155 128 105 - - HYPH cord-267001-csgmc155 128 106 adjuvanted adjuvante VBN cord-267001-csgmc155 128 107 RBD RBD NNP cord-267001-csgmc155 128 108 vaccine vaccine NN cord-267001-csgmc155 128 109 ( ( -LRB- cord-267001-csgmc155 128 110 G4 G4 NNP cord-267001-csgmc155 128 111 - - HYPH cord-267001-csgmc155 128 112 53,104 53,104 CD cord-267001-csgmc155 128 113 end end NN cord-267001-csgmc155 128 114 point point NN cord-267001-csgmc155 128 115 titer titer NN cord-267001-csgmc155 128 116 ; ; : cord-267001-csgmc155 128 117 Figure figure NN cord-267001-csgmc155 128 118 S1A s1a NN cord-267001-csgmc155 128 119 ) ) -RRB- cord-267001-csgmc155 128 120 . . . cord-267001-csgmc155 129 1 Nevertheless nevertheless RB cord-267001-csgmc155 129 2 , , , cord-267001-csgmc155 129 3 the the DT cord-267001-csgmc155 129 4 co co NN cord-267001-csgmc155 129 5 - - NN cord-267001-csgmc155 129 6 administration administration NN cord-267001-csgmc155 129 7 of of IN cord-267001-csgmc155 129 8 rASP-1 rASP-1 NNP cord-267001-csgmc155 129 9 and and CC cord-267001-csgmc155 129 10 the the DT cord-267001-csgmc155 129 11 alum alum NN cord-267001-csgmc155 129 12 - - HYPH cord-267001-csgmc155 129 13 adjuvanted adjuvante VBN cord-267001-csgmc155 129 14 RBD RBD NNP cord-267001-csgmc155 129 15 vaccine vaccine NN cord-267001-csgmc155 129 16 in in IN cord-267001-csgmc155 129 17 separate separate JJ cord-267001-csgmc155 129 18 sites site NNS cord-267001-csgmc155 129 19 significantly significantly RB cord-267001-csgmc155 129 20 increased increase VBD cord-267001-csgmc155 129 21 the the DT cord-267001-csgmc155 129 22 RBD RBD NNP cord-267001-csgmc155 129 23 - - HYPH cord-267001-csgmc155 129 24 specific specific JJ cord-267001-csgmc155 129 25 total total JJ cord-267001-csgmc155 129 26 IgG igg NN cord-267001-csgmc155 129 27 antibody antibody NN cord-267001-csgmc155 129 28 titers titer NNS cord-267001-csgmc155 129 29 by~20-fold by~20-fold NNP cord-267001-csgmc155 129 30 compared compare VBD cord-267001-csgmc155 129 31 to to IN cord-267001-csgmc155 129 32 rASP-1-adjuvanted rASP-1-adjuvanted NNP cord-267001-csgmc155 129 33 MERS MERS NNP cord-267001-csgmc155 129 34 - - HYPH cord-267001-csgmc155 129 35 RBD RBD NNP cord-267001-csgmc155 129 36 vaccine vaccine NN cord-267001-csgmc155 129 37 or~160-fold or~160-fold NN cord-267001-csgmc155 129 38 compared compare VBN cord-267001-csgmc155 129 39 to to IN cord-267001-csgmc155 129 40 the the DT cord-267001-csgmc155 129 41 RBD RBD NNP cord-267001-csgmc155 129 42 vaccine vaccine NN cord-267001-csgmc155 129 43 alone alone RB cord-267001-csgmc155 129 44 ( ( -LRB- cord-267001-csgmc155 129 45 G6 G6 NNP cord-267001-csgmc155 129 46 - - HYPH cord-267001-csgmc155 129 47 142,525 142,525 CD cord-267001-csgmc155 129 48 , , , cord-267001-csgmc155 129 49 G3 G3 NNP cord-267001-csgmc155 129 50 - - HYPH cord-267001-csgmc155 129 51 6700 6700 CD cord-267001-csgmc155 129 52 and and CC cord-267001-csgmc155 129 53 G2 G2 NNP cord-267001-csgmc155 129 54 - - HYPH cord-267001-csgmc155 129 55 872 872 CD cord-267001-csgmc155 129 56 end end NN cord-267001-csgmc155 129 57 point point NN cord-267001-csgmc155 129 58 titers titer NNS cord-267001-csgmc155 129 59 respectively respectively RB cord-267001-csgmc155 129 60 ; ; : cord-267001-csgmc155 129 61 Figure figure NN cord-267001-csgmc155 129 62 S1A s1a NN cord-267001-csgmc155 129 63 ) ) -RRB- cord-267001-csgmc155 129 64 ; ; : cord-267001-csgmc155 129 65 clearly clearly RB cord-267001-csgmc155 129 66 showing show VBG cord-267001-csgmc155 129 67 that that IN cord-267001-csgmc155 129 68 immunization immunization NN cord-267001-csgmc155 129 69 using use VBG cord-267001-csgmc155 129 70 the the DT cord-267001-csgmc155 129 71 unique unique JJ cord-267001-csgmc155 129 72 rASP-1 rasp-1 NN cord-267001-csgmc155 129 73 and and CC cord-267001-csgmc155 129 74 alum alum NN cord-267001-csgmc155 129 75 combinational combinational JJ cord-267001-csgmc155 129 76 adjuvants adjuvant NNS cord-267001-csgmc155 129 77 had have VBD cord-267001-csgmc155 129 78 a a DT cord-267001-csgmc155 129 79 beneficiary beneficiary NN cord-267001-csgmc155 129 80 effect effect NN cord-267001-csgmc155 129 81 in in IN cord-267001-csgmc155 129 82 comparison comparison NN cord-267001-csgmc155 129 83 to to IN cord-267001-csgmc155 129 84 the the DT cord-267001-csgmc155 129 85 rASP-1 rASP-1 VBN cord-267001-csgmc155 129 86 ( ( -LRB- cord-267001-csgmc155 129 87 ~20 ~20 NFP cord-267001-csgmc155 129 88 fold fold VB cord-267001-csgmc155 129 89 ) ) -RRB- cord-267001-csgmc155 129 90 or or CC cord-267001-csgmc155 129 91 the the DT cord-267001-csgmc155 129 92 alum alum NN cord-267001-csgmc155 129 93 ( ( -LRB- cord-267001-csgmc155 129 94 ~3 ~3 NFP cord-267001-csgmc155 129 95 fold fold VB cord-267001-csgmc155 129 96 ) ) -RRB- cord-267001-csgmc155 129 97 adjuvanted adjuvante VBN cord-267001-csgmc155 129 98 vaccines vaccine NNS cord-267001-csgmc155 129 99 . . . cord-267001-csgmc155 130 1 To to TO cord-267001-csgmc155 130 2 elucidate elucidate VB cord-267001-csgmc155 130 3 the the DT cord-267001-csgmc155 130 4 IgG igg NN cord-267001-csgmc155 130 5 subtypes subtype NNS cord-267001-csgmc155 130 6 induced induce VBN cord-267001-csgmc155 130 7 in in IN cord-267001-csgmc155 130 8 the the DT cord-267001-csgmc155 130 9 different different JJ cord-267001-csgmc155 130 10 immunization immunization NN cord-267001-csgmc155 130 11 groups group NNS cord-267001-csgmc155 130 12 , , , cord-267001-csgmc155 130 13 we -PRON- PRP cord-267001-csgmc155 130 14 also also RB cord-267001-csgmc155 130 15 analyzed analyze VBD cord-267001-csgmc155 130 16 the the DT cord-267001-csgmc155 130 17 RBD RBD NNP cord-267001-csgmc155 130 18 - - HYPH cord-267001-csgmc155 130 19 specific specific JJ cord-267001-csgmc155 130 20 IgG1 igg1 NN cord-267001-csgmc155 130 21 and and CC cord-267001-csgmc155 130 22 IgG2c IgG2c NNP cord-267001-csgmc155 130 23 antibody antibody NN cord-267001-csgmc155 130 24 titers titer NNS cord-267001-csgmc155 130 25 . . . cord-267001-csgmc155 131 1 We -PRON- PRP cord-267001-csgmc155 131 2 observed observe VBD cord-267001-csgmc155 131 3 that that IN cord-267001-csgmc155 131 4 the the DT cord-267001-csgmc155 131 5 highest high JJS cord-267001-csgmc155 131 6 titer titer NN cord-267001-csgmc155 131 7 of of IN cord-267001-csgmc155 131 8 IgG1 IgG1 NNP cord-267001-csgmc155 131 9 antibodies antibody NNS cord-267001-csgmc155 131 10 was be VBD cord-267001-csgmc155 131 11 induced induce VBN cord-267001-csgmc155 131 12 when when WRB cord-267001-csgmc155 131 13 the the DT cord-267001-csgmc155 131 14 RBD RBD NNP cord-267001-csgmc155 131 15 vaccine vaccine NN cord-267001-csgmc155 131 16 was be VBD cord-267001-csgmc155 131 17 formulated formulate VBN cord-267001-csgmc155 131 18 with with IN cord-267001-csgmc155 131 19 alum alum NN cord-267001-csgmc155 131 20 alone alone RB cord-267001-csgmc155 131 21 or or CC cord-267001-csgmc155 131 22 with with IN cord-267001-csgmc155 131 23 rASP-1 rasp-1 ADD cord-267001-csgmc155 132 1 + + CC cord-267001-csgmc155 133 1 alum alum NN cord-267001-csgmc155 133 2 in in IN cord-267001-csgmc155 133 3 one one CD cord-267001-csgmc155 133 4 inoculum inoculum NN cord-267001-csgmc155 134 1 ( ( -LRB- cord-267001-csgmc155 134 2 G4 G4 NNP cord-267001-csgmc155 134 3 - - HYPH cord-267001-csgmc155 134 4 250,951 250,951 CD cord-267001-csgmc155 134 5 and and CC cord-267001-csgmc155 135 1 G5 G5 NNP cord-267001-csgmc155 135 2 - - HYPH cord-267001-csgmc155 135 3 369,000 369,000 CD cord-267001-csgmc155 135 4 end end NN cord-267001-csgmc155 135 5 point point NN cord-267001-csgmc155 135 6 titers titer NNS cord-267001-csgmc155 135 7 respectively respectively RB cord-267001-csgmc155 135 8 ; ; : cord-267001-csgmc155 135 9 Figure figure NN cord-267001-csgmc155 135 10 S1B s1b NN cord-267001-csgmc155 135 11 ) ) -RRB- cord-267001-csgmc155 135 12 , , , cord-267001-csgmc155 135 13 with with IN cord-267001-csgmc155 135 14 the the DT cord-267001-csgmc155 135 15 titers titer NNS cord-267001-csgmc155 135 16 being be VBG cord-267001-csgmc155 135 17 significantly significantly RB cord-267001-csgmc155 135 18 higher high JJR cord-267001-csgmc155 135 19 when when WRB cord-267001-csgmc155 135 20 the the DT cord-267001-csgmc155 135 21 vaccine vaccine NN cord-267001-csgmc155 135 22 was be VBD cord-267001-csgmc155 135 23 with with IN cord-267001-csgmc155 135 24 both both DT cord-267001-csgmc155 135 25 adjuvants adjuvant NNS cord-267001-csgmc155 135 26 and and CC cord-267001-csgmc155 135 27 in in IN cord-267001-csgmc155 135 28 one one CD cord-267001-csgmc155 135 29 inoculum inoculum NN cord-267001-csgmc155 135 30 . . . cord-267001-csgmc155 136 1 The the DT cord-267001-csgmc155 136 2 RBD RBD NNP cord-267001-csgmc155 136 3 - - HYPH cord-267001-csgmc155 136 4 specific specific JJ cord-267001-csgmc155 136 5 IgG1 IgG1 NNS cord-267001-csgmc155 136 6 titers titer NNS cord-267001-csgmc155 136 7 were be VBD cord-267001-csgmc155 136 8 significantly significantly RB cord-267001-csgmc155 136 9 decreased decrease VBN cord-267001-csgmc155 136 10 when when WRB cord-267001-csgmc155 136 11 rASP-1 rASP-1 NNP cord-267001-csgmc155 136 12 was be VBD cord-267001-csgmc155 136 13 used use VBN cord-267001-csgmc155 136 14 as as IN cord-267001-csgmc155 136 15 an an DT cord-267001-csgmc155 136 16 adjuvant adjuvant NN cord-267001-csgmc155 136 17 in in IN cord-267001-csgmc155 136 18 aqueous aqueous JJ cord-267001-csgmc155 136 19 formulations formulation NNS cord-267001-csgmc155 136 20 ; ; : cord-267001-csgmc155 136 21 when when WRB cord-267001-csgmc155 136 22 the the DT cord-267001-csgmc155 136 23 rASP-1 rasp-1 NN cord-267001-csgmc155 136 24 and and CC cord-267001-csgmc155 136 25 the the DT cord-267001-csgmc155 136 26 alum alum NN cord-267001-csgmc155 136 27 - - HYPH cord-267001-csgmc155 136 28 adjuvanted adjuvante VBN cord-267001-csgmc155 136 29 RBD RBD NNP cord-267001-csgmc155 136 30 were be VBD cord-267001-csgmc155 136 31 co co VBN cord-267001-csgmc155 136 32 - - VBN cord-267001-csgmc155 136 33 administered administer VBN cord-267001-csgmc155 136 34 in in IN cord-267001-csgmc155 136 35 separate separate JJ cord-267001-csgmc155 136 36 sites site NNS cord-267001-csgmc155 136 37 ( ( -LRB- cord-267001-csgmc155 136 38 ~7-fold ~7-fold NNP cord-267001-csgmc155 136 39 decrease decrease NN cord-267001-csgmc155 136 40 ; ; : cord-267001-csgmc155 136 41 G6 G6 NNP cord-267001-csgmc155 136 42 - - HYPH cord-267001-csgmc155 136 43 55,945 55,945 CD cord-267001-csgmc155 136 44 end end NN cord-267001-csgmc155 136 45 point point NN cord-267001-csgmc155 136 46 titers titer NNS cord-267001-csgmc155 136 47 ) ) -RRB- cord-267001-csgmc155 136 48 or or CC cord-267001-csgmc155 136 49 with with IN cord-267001-csgmc155 136 50 the the DT cord-267001-csgmc155 136 51 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 136 52 RBD RBD NNP cord-267001-csgmc155 136 53 vaccine vaccine NN cord-267001-csgmc155 136 54 ( ( -LRB- cord-267001-csgmc155 136 55 ~40-fold ~40-fold NNP cord-267001-csgmc155 136 56 decrease decrease NN cord-267001-csgmc155 136 57 ; ; : cord-267001-csgmc155 136 58 G3 G3 NNP cord-267001-csgmc155 136 59 - - HYPH cord-267001-csgmc155 136 60 9165 9165 CD cord-267001-csgmc155 136 61 end end NN cord-267001-csgmc155 136 62 point point NN cord-267001-csgmc155 136 63 titers titer NNS cord-267001-csgmc155 136 64 ) ) -RRB- cord-267001-csgmc155 136 65 when when WRB cord-267001-csgmc155 136 66 it -PRON- PRP cord-267001-csgmc155 136 67 was be VBD cord-267001-csgmc155 136 68 compared compare VBN cord-267001-csgmc155 136 69 to to IN cord-267001-csgmc155 136 70 the the DT cord-267001-csgmc155 136 71 administration administration NN cord-267001-csgmc155 136 72 of of IN cord-267001-csgmc155 136 73 RBD RBD NNP cord-267001-csgmc155 136 74 + + CC cord-267001-csgmc155 137 1 rASP-1 rasp-1 LS cord-267001-csgmc155 137 2 + + CC cord-267001-csgmc155 137 3 alum alum NN cord-267001-csgmc155 137 4 in in IN cord-267001-csgmc155 137 5 a a DT cord-267001-csgmc155 137 6 single single JJ cord-267001-csgmc155 137 7 inoculum inoculum NN cord-267001-csgmc155 137 8 ( ( -LRB- cord-267001-csgmc155 137 9 G5 G5 NNP cord-267001-csgmc155 137 10 - - HYPH cord-267001-csgmc155 137 11 369,000 369,000 CD cord-267001-csgmc155 137 12 end end NN cord-267001-csgmc155 137 13 point point NN cord-267001-csgmc155 137 14 titers titer NNS cord-267001-csgmc155 137 15 ; ; : cord-267001-csgmc155 137 16 Figure figure NN cord-267001-csgmc155 137 17 S1B s1b NN cord-267001-csgmc155 137 18 ) ) -RRB- cord-267001-csgmc155 137 19 . . . cord-267001-csgmc155 138 1 rASP-1 rASP-1 NNP cord-267001-csgmc155 138 2 is be VBZ cord-267001-csgmc155 138 3 known know VBN cord-267001-csgmc155 138 4 as as IN cord-267001-csgmc155 138 5 an an DT cord-267001-csgmc155 138 6 IgG2 igg2 NN cord-267001-csgmc155 138 7 ( ( -LRB- cord-267001-csgmc155 138 8 Th1)-biased th1)-biased JJ cord-267001-csgmc155 138 9 adjuvant adjuvant NN cord-267001-csgmc155 138 10 [ [ -LRB- cord-267001-csgmc155 138 11 8 8 CD cord-267001-csgmc155 138 12 ] ] -RRB- cord-267001-csgmc155 138 13 . . . cord-267001-csgmc155 139 1 Notably notably RB cord-267001-csgmc155 139 2 , , , cord-267001-csgmc155 139 3 IgG2c igg2c JJ cord-267001-csgmc155 139 4 responses response NNS cord-267001-csgmc155 139 5 were be VBD cord-267001-csgmc155 139 6 only only RB cord-267001-csgmc155 139 7 elevated elevate VBN cord-267001-csgmc155 139 8 when when WRB cord-267001-csgmc155 139 9 rASP-1 rASP-1 NNP cord-267001-csgmc155 139 10 was be VBD cord-267001-csgmc155 139 11 also also RB cord-267001-csgmc155 139 12 administered administer VBN cord-267001-csgmc155 139 13 as as IN cord-267001-csgmc155 139 14 an an DT cord-267001-csgmc155 139 15 adjuvant adjuvant NN cord-267001-csgmc155 139 16 ( ( -LRB- cord-267001-csgmc155 139 17 G3 G3 NNP cord-267001-csgmc155 139 18 - - HYPH cord-267001-csgmc155 139 19 254 254 CD cord-267001-csgmc155 139 20 , , , cord-267001-csgmc155 139 21 G5 G5 NNP cord-267001-csgmc155 139 22 - - HYPH cord-267001-csgmc155 139 23 1064 1064 CD cord-267001-csgmc155 139 24 , , , cord-267001-csgmc155 139 25 and and CC cord-267001-csgmc155 139 26 G6 G6 NNP cord-267001-csgmc155 139 27 - - HYPH cord-267001-csgmc155 139 28 726 726 CD cord-267001-csgmc155 139 29 end end NN cord-267001-csgmc155 139 30 point point NN cord-267001-csgmc155 139 31 titers titer NNS cord-267001-csgmc155 139 32 ) ) -RRB- cord-267001-csgmc155 139 33 , , , cord-267001-csgmc155 139 34 with with IN cord-267001-csgmc155 139 35 the the DT cord-267001-csgmc155 139 36 combinatorial combinatorial JJ cord-267001-csgmc155 139 37 adjuvanted adjuvante VBN cord-267001-csgmc155 139 38 vaccines vaccine NNS cord-267001-csgmc155 139 39 performing perform VBG cord-267001-csgmc155 139 40 similarly similarly RB cord-267001-csgmc155 139 41 and and CC cord-267001-csgmc155 139 42 best good JJS cord-267001-csgmc155 139 43 ( ( -LRB- cord-267001-csgmc155 139 44 G5 G5 NNP cord-267001-csgmc155 139 45 and and CC cord-267001-csgmc155 139 46 G6 G6 NNP cord-267001-csgmc155 139 47 ; ; : cord-267001-csgmc155 139 48 Figure Figure NNP cord-267001-csgmc155 139 49 S1C s1c CD cord-267001-csgmc155 139 50 ) ) -RRB- cord-267001-csgmc155 139 51 . . . cord-267001-csgmc155 140 1 These these DT cord-267001-csgmc155 140 2 data datum NNS cord-267001-csgmc155 140 3 suggest suggest VBP cord-267001-csgmc155 140 4 that that IN cord-267001-csgmc155 140 5 when when WRB cord-267001-csgmc155 140 6 rASP-1 rASP-1 NNP cord-267001-csgmc155 140 7 is be VBZ cord-267001-csgmc155 140 8 adsorbed adsorb VBN cord-267001-csgmc155 140 9 to to IN cord-267001-csgmc155 140 10 alum alum NN cord-267001-csgmc155 140 11 in in IN cord-267001-csgmc155 140 12 a a DT cord-267001-csgmc155 140 13 vaccine vaccine NN cord-267001-csgmc155 140 14 formulation formulation NN cord-267001-csgmc155 140 15 ( ( -LRB- cord-267001-csgmc155 140 16 G5 G5 NNP cord-267001-csgmc155 140 17 ) ) -RRB- cord-267001-csgmc155 140 18 , , , cord-267001-csgmc155 140 19 the the DT cord-267001-csgmc155 140 20 two two CD cord-267001-csgmc155 140 21 adjuvants adjuvant NNS cord-267001-csgmc155 140 22 work work VBP cord-267001-csgmc155 140 23 in in IN cord-267001-csgmc155 140 24 synergy synergy NN cord-267001-csgmc155 140 25 not not RB cord-267001-csgmc155 140 26 only only RB cord-267001-csgmc155 140 27 to to TO cord-267001-csgmc155 140 28 elicit elicit VB cord-267001-csgmc155 140 29 a a DT cord-267001-csgmc155 140 30 stronger strong JJR cord-267001-csgmc155 140 31 IgG1 igg1 NN cord-267001-csgmc155 140 32 response response NN cord-267001-csgmc155 140 33 than than IN cord-267001-csgmc155 140 34 the the DT cord-267001-csgmc155 140 35 alum alum NN cord-267001-csgmc155 140 36 - - HYPH cord-267001-csgmc155 140 37 adjuvanted adjuvante VBN cord-267001-csgmc155 140 38 vaccine vaccine NN cord-267001-csgmc155 140 39 formulation formulation NN cord-267001-csgmc155 140 40 , , , cord-267001-csgmc155 140 41 but but CC cord-267001-csgmc155 140 42 also also RB cord-267001-csgmc155 140 43 for for IN cord-267001-csgmc155 140 44 inducing induce VBG cord-267001-csgmc155 140 45 the the DT cord-267001-csgmc155 140 46 IgG2c IgG2c NNP cord-267001-csgmc155 140 47 antibody antibody NN cord-267001-csgmc155 140 48 response response NN cord-267001-csgmc155 140 49 as as IN cord-267001-csgmc155 140 50 compared compare VBN cord-267001-csgmc155 140 51 to to IN cord-267001-csgmc155 140 52 alum alum NN cord-267001-csgmc155 140 53 - - HYPH cord-267001-csgmc155 140 54 adjuvanted adjuvante VBN cord-267001-csgmc155 140 55 vaccine vaccine NN cord-267001-csgmc155 140 56 formulation formulation NN cord-267001-csgmc155 140 57 alone alone RB cord-267001-csgmc155 140 58 ( ( -LRB- cord-267001-csgmc155 140 59 ~14-fold ~14-fold NFP cord-267001-csgmc155 140 60 increase increase NN cord-267001-csgmc155 140 61 ) ) -RRB- cord-267001-csgmc155 140 62 , , , cord-267001-csgmc155 140 63 suggesting suggest VBG cord-267001-csgmc155 140 64 that that IN cord-267001-csgmc155 140 65 the the DT cord-267001-csgmc155 140 66 combination combination NN cord-267001-csgmc155 140 67 of of IN cord-267001-csgmc155 140 68 rASP-1 rasp-1 NN cord-267001-csgmc155 140 69 and and CC cord-267001-csgmc155 140 70 alum alum NN cord-267001-csgmc155 140 71 in in IN cord-267001-csgmc155 140 72 a a DT cord-267001-csgmc155 140 73 vaccine vaccine NN cord-267001-csgmc155 140 74 with with IN cord-267001-csgmc155 140 75 the the DT cord-267001-csgmc155 140 76 RBD RBD NNP cord-267001-csgmc155 140 77 antigen antigen NN cord-267001-csgmc155 140 78 works work VBZ cord-267001-csgmc155 140 79 in in IN cord-267001-csgmc155 140 80 synergy synergy NN cord-267001-csgmc155 140 81 to to TO cord-267001-csgmc155 140 82 elicit elicit VB cord-267001-csgmc155 140 83 a a DT cord-267001-csgmc155 140 84 more more RBR cord-267001-csgmc155 140 85 balanced balanced JJ cord-267001-csgmc155 140 86 IgG1-IgG2c IgG1-IgG2c NNP cord-267001-csgmc155 140 87 antibody antibody NN cord-267001-csgmc155 140 88 response response NN cord-267001-csgmc155 140 89 ( ( -LRB- cord-267001-csgmc155 140 90 IgG1 IgG1 NNP cord-267001-csgmc155 140 91 / / SYM cord-267001-csgmc155 140 92 IgG2c IgG2c NNP cord-267001-csgmc155 140 93 ratio ratio NN cord-267001-csgmc155 140 94 of of IN cord-267001-csgmc155 140 95 1626 1626 CD cord-267001-csgmc155 140 96 in in IN cord-267001-csgmc155 140 97 G5 G5 NNP cord-267001-csgmc155 140 98 vs. vs. IN cord-267001-csgmc155 140 99 4403 4403 CD cord-267001-csgmc155 140 100 in in IN cord-267001-csgmc155 140 101 G4 G4 NNP cord-267001-csgmc155 140 102 ; ; : cord-267001-csgmc155 140 103 Figure figure NN cord-267001-csgmc155 140 104 S1D s1d NN cord-267001-csgmc155 140 105 ) ) -RRB- cord-267001-csgmc155 140 106 . . . cord-267001-csgmc155 141 1 The the DT cord-267001-csgmc155 141 2 reduced reduce VBN cord-267001-csgmc155 141 3 IgG1 igg1 NN cord-267001-csgmc155 141 4 / / SYM cord-267001-csgmc155 141 5 IgG2c IgG2c NNP cord-267001-csgmc155 141 6 ratio ratio NN cord-267001-csgmc155 141 7 is be VBZ cord-267001-csgmc155 141 8 more more RBR cord-267001-csgmc155 141 9 pronounced pronounced JJ cord-267001-csgmc155 141 10 in in IN cord-267001-csgmc155 141 11 a a DT cord-267001-csgmc155 141 12 vaccine vaccine NN cord-267001-csgmc155 141 13 formulation formulation NN cord-267001-csgmc155 141 14 where where WRB cord-267001-csgmc155 141 15 rASP-1 rASP-1 NNP cord-267001-csgmc155 141 16 is be VBZ cord-267001-csgmc155 141 17 not not RB cord-267001-csgmc155 141 18 adsorbed adsorb VBN cord-267001-csgmc155 141 19 to to IN cord-267001-csgmc155 141 20 alum alum NN cord-267001-csgmc155 141 21 but but CC cord-267001-csgmc155 141 22 co co NNS cord-267001-csgmc155 141 23 - - VBN cord-267001-csgmc155 141 24 administered administer VBN cord-267001-csgmc155 141 25 separately separately RB cord-267001-csgmc155 141 26 ( ( -LRB- cord-267001-csgmc155 141 27 IgG1 IgG1 NNP cord-267001-csgmc155 141 28 / / SYM cord-267001-csgmc155 141 29 IgG2c IgG2c NNP cord-267001-csgmc155 141 30 ratio ratio NN cord-267001-csgmc155 141 31 of of IN cord-267001-csgmc155 141 32 601 601 CD cord-267001-csgmc155 141 33 in in IN cord-267001-csgmc155 141 34 G6 G6 NNP cord-267001-csgmc155 141 35 ; ; . cord-267001-csgmc155 142 1 Figure figure NN cord-267001-csgmc155 142 2 S1D s1d NN cord-267001-csgmc155 142 3 ) ) -RRB- cord-267001-csgmc155 142 4 . . . cord-267001-csgmc155 143 1 Sera Sera NNP cord-267001-csgmc155 143 2 samples sample NNS cord-267001-csgmc155 143 3 from from IN cord-267001-csgmc155 143 4 day day NN cord-267001-csgmc155 143 5 7 7 CD cord-267001-csgmc155 143 6 post-2nd post-2nd NN cord-267001-csgmc155 143 7 immunization immunization NN cord-267001-csgmc155 143 8 were be VBD cord-267001-csgmc155 143 9 also also RB cord-267001-csgmc155 143 10 tested test VBN cord-267001-csgmc155 143 11 for for IN cord-267001-csgmc155 143 12 their -PRON- PRP$ cord-267001-csgmc155 143 13 ability ability NN cord-267001-csgmc155 143 14 to to TO cord-267001-csgmc155 143 15 inhibit inhibit VB cord-267001-csgmc155 143 16 the the DT cord-267001-csgmc155 143 17 binding binding NN cord-267001-csgmc155 143 18 of of IN cord-267001-csgmc155 143 19 MERS MERS NNP cord-267001-csgmc155 143 20 - - HYPH cord-267001-csgmc155 143 21 RBD RBD NNP cord-267001-csgmc155 143 22 - - HYPH cord-267001-csgmc155 143 23 Fc Fc NNP cord-267001-csgmc155 143 24 protein protein NN cord-267001-csgmc155 143 25 to to IN cord-267001-csgmc155 143 26 the the DT cord-267001-csgmc155 143 27 hDPP4 hdpp4 NN cord-267001-csgmc155 143 28 receptor receptor NN cord-267001-csgmc155 143 29 - - HYPH cord-267001-csgmc155 143 30 expressing express VBG cord-267001-csgmc155 143 31 Huh-7 Huh-7 NNP cord-267001-csgmc155 143 32 cells cell NNS cord-267001-csgmc155 143 33 by by IN cord-267001-csgmc155 143 34 flow flow NN cord-267001-csgmc155 143 35 cytometry cytometry NN cord-267001-csgmc155 143 36 . . . cord-267001-csgmc155 144 1 Similarly similarly RB cord-267001-csgmc155 144 2 to to IN cord-267001-csgmc155 144 3 the the DT cord-267001-csgmc155 144 4 enhanced enhance VBN cord-267001-csgmc155 144 5 induction induction NN cord-267001-csgmc155 144 6 of of IN cord-267001-csgmc155 144 7 neutralizing neutralize VBG cord-267001-csgmc155 144 8 antibodies antibody NNS cord-267001-csgmc155 144 9 , , , cord-267001-csgmc155 144 10 immunization immunization NN cord-267001-csgmc155 144 11 with with IN cord-267001-csgmc155 144 12 rASP-1 rASP-1 NNP cord-267001-csgmc155 144 13 and and CC cord-267001-csgmc155 144 14 the the DT cord-267001-csgmc155 144 15 alum alum NN cord-267001-csgmc155 144 16 - - HYPH cord-267001-csgmc155 144 17 adjuvanted adjuvante VBN cord-267001-csgmc155 144 18 RBD RBD NNP cord-267001-csgmc155 144 19 vaccine vaccine NN cord-267001-csgmc155 144 20 in in IN cord-267001-csgmc155 144 21 separate separate JJ cord-267001-csgmc155 144 22 injection injection NN cord-267001-csgmc155 144 23 sites site NNS cord-267001-csgmc155 144 24 also also RB cord-267001-csgmc155 144 25 increased increase VBD cord-267001-csgmc155 144 26 the the DT cord-267001-csgmc155 144 27 ability ability NN cord-267001-csgmc155 144 28 of of IN cord-267001-csgmc155 144 29 the the DT cord-267001-csgmc155 144 30 generated generate VBN cord-267001-csgmc155 144 31 antibodies antibody NNS cord-267001-csgmc155 144 32 to to TO cord-267001-csgmc155 144 33 inhibit inhibit VB cord-267001-csgmc155 144 34 the the DT cord-267001-csgmc155 144 35 binding binding NN cord-267001-csgmc155 144 36 of of IN cord-267001-csgmc155 144 37 the the DT cord-267001-csgmc155 144 38 RBD RBD NNP cord-267001-csgmc155 144 39 protein protein NN cord-267001-csgmc155 144 40 to to IN cord-267001-csgmc155 144 41 its -PRON- PRP$ cord-267001-csgmc155 144 42 receptor receptor NN cord-267001-csgmc155 144 43 by~2-fold by~2-fold NNP cord-267001-csgmc155 144 44 ( ( -LRB- cord-267001-csgmc155 144 45 G6 G6 NNP cord-267001-csgmc155 144 46 - - HYPH cord-267001-csgmc155 144 47 50 50 CD cord-267001-csgmc155 144 48 % % NN cord-267001-csgmc155 144 49 ; ; : cord-267001-csgmc155 144 50 Figure figure NN cord-267001-csgmc155 144 51 2 2 CD cord-267001-csgmc155 144 52 ) ) -RRB- cord-267001-csgmc155 144 53 as as IN cord-267001-csgmc155 144 54 compared compare VBN cord-267001-csgmc155 144 55 to to IN cord-267001-csgmc155 144 56 RBD RBD NNP cord-267001-csgmc155 144 57 + + CC cord-267001-csgmc155 144 58 rASP-1 rasp-1 CD cord-267001-csgmc155 144 59 + + CC cord-267001-csgmc155 144 60 alum alum NN cord-267001-csgmc155 144 61 adjuvanted adjuvanted JJ cord-267001-csgmc155 144 62 vaccine vaccine NN cord-267001-csgmc155 144 63 in in IN cord-267001-csgmc155 144 64 a a DT cord-267001-csgmc155 144 65 single single JJ cord-267001-csgmc155 144 66 inoculum inoculum NN cord-267001-csgmc155 144 67 or or CC cord-267001-csgmc155 144 68 with with IN cord-267001-csgmc155 144 69 alum alum NN cord-267001-csgmc155 144 70 - - HYPH cord-267001-csgmc155 144 71 adjuvanted adjuvante VBN cord-267001-csgmc155 144 72 RBD RBD NNP cord-267001-csgmc155 144 73 vaccine vaccine NN cord-267001-csgmc155 144 74 ( ( -LRB- cord-267001-csgmc155 144 75 G5 G5 NNP cord-267001-csgmc155 144 76 - - HYPH cord-267001-csgmc155 144 77 25 25 CD cord-267001-csgmc155 144 78 % % NN cord-267001-csgmc155 144 79 and and CC cord-267001-csgmc155 144 80 G4 G4 NNP cord-267001-csgmc155 144 81 - - HYPH cord-267001-csgmc155 144 82 35 35 CD cord-267001-csgmc155 144 83 % % NN cord-267001-csgmc155 144 84 ; ; : cord-267001-csgmc155 144 85 Figure figure NN cord-267001-csgmc155 144 86 2 2 CD cord-267001-csgmc155 144 87 ) ) -RRB- cord-267001-csgmc155 144 88 , , , cord-267001-csgmc155 144 89 and and CC cord-267001-csgmc155 144 90 by by IN cord-267001-csgmc155 144 91 > > XX cord-267001-csgmc155 144 92 3-fold 3-fold CD cord-267001-csgmc155 144 93 as as IN cord-267001-csgmc155 144 94 compared compare VBN cord-267001-csgmc155 144 95 to to IN cord-267001-csgmc155 144 96 the the DT cord-267001-csgmc155 144 97 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 144 98 RBD RBD NNP cord-267001-csgmc155 144 99 vaccine vaccine NN cord-267001-csgmc155 144 100 ( ( -LRB- cord-267001-csgmc155 144 101 G3 G3 NNP cord-267001-csgmc155 144 102 - - HYPH cord-267001-csgmc155 144 103 16 16 CD cord-267001-csgmc155 144 104 % % NN cord-267001-csgmc155 144 105 ; ; : cord-267001-csgmc155 144 106 Figure figure NN cord-267001-csgmc155 144 107 2 2 CD cord-267001-csgmc155 144 108 ) ) -RRB- cord-267001-csgmc155 144 109 . . . cord-267001-csgmc155 145 1 When when WRB cord-267001-csgmc155 145 2 group group NN cord-267001-csgmc155 145 3 G6 G6 NNP cord-267001-csgmc155 145 4 was be VBD cord-267001-csgmc155 145 5 compared compare VBN cord-267001-csgmc155 145 6 to to IN cord-267001-csgmc155 145 7 groups group NNS cord-267001-csgmc155 145 8 G3 G3 NNP cord-267001-csgmc155 145 9 and and CC cord-267001-csgmc155 145 10 G4 G4 NNP cord-267001-csgmc155 145 11 , , , cord-267001-csgmc155 145 12 a a DT cord-267001-csgmc155 145 13 synergy synergy NN cord-267001-csgmc155 145 14 of of IN cord-267001-csgmc155 145 15 the the DT cord-267001-csgmc155 145 16 combinatorial combinatorial JJ cord-267001-csgmc155 145 17 adjuvants adjuvant NNS cord-267001-csgmc155 145 18 , , , cord-267001-csgmc155 145 19 though though IN cord-267001-csgmc155 145 20 when when WRB cord-267001-csgmc155 145 21 rASP-1 rASP-1 NNP cord-267001-csgmc155 145 22 is be VBZ cord-267001-csgmc155 145 23 not not RB cord-267001-csgmc155 145 24 adsorbed adsorb VBN cord-267001-csgmc155 145 25 to to IN cord-267001-csgmc155 145 26 alum alum NN cord-267001-csgmc155 145 27 , , , cord-267001-csgmc155 145 28 was be VBD cord-267001-csgmc155 145 29 evident evident JJ cord-267001-csgmc155 145 30 . . . cord-267001-csgmc155 146 1 However however RB cord-267001-csgmc155 146 2 , , , cord-267001-csgmc155 146 3 when when WRB cord-267001-csgmc155 146 4 rASP-1 rASP-1 NNP cord-267001-csgmc155 146 5 was be VBD cord-267001-csgmc155 146 6 adsorbed adsorb VBN cord-267001-csgmc155 146 7 to to IN cord-267001-csgmc155 146 8 alum alum NN cord-267001-csgmc155 146 9 ( ( -LRB- cord-267001-csgmc155 146 10 G5 G5 NNP cord-267001-csgmc155 146 11 ) ) -RRB- cord-267001-csgmc155 146 12 , , , cord-267001-csgmc155 146 13 the the DT cord-267001-csgmc155 146 14 functionality functionality NN cord-267001-csgmc155 146 15 of of IN cord-267001-csgmc155 146 16 the the DT cord-267001-csgmc155 146 17 antibodies antibody NNS cord-267001-csgmc155 146 18 elicited elicit VBN cord-267001-csgmc155 146 19 by by IN cord-267001-csgmc155 146 20 the the DT cord-267001-csgmc155 146 21 vaccine vaccine NN cord-267001-csgmc155 146 22 is be VBZ cord-267001-csgmc155 146 23 much much RB cord-267001-csgmc155 146 24 reduced reduce VBN cord-267001-csgmc155 146 25 . . . cord-267001-csgmc155 147 1 The the DT cord-267001-csgmc155 147 2 inhibitory inhibitory JJ cord-267001-csgmc155 147 3 activity activity NN cord-267001-csgmc155 147 4 in in IN cord-267001-csgmc155 147 5 group group NN cord-267001-csgmc155 147 6 G5 G5 NNP cord-267001-csgmc155 147 7 was be VBD cord-267001-csgmc155 147 8 reduced reduce VBN cord-267001-csgmc155 147 9 by~30 by~30 NNP cord-267001-csgmc155 147 10 % % NN cord-267001-csgmc155 147 11 , , , cord-267001-csgmc155 147 12 albeit albeit IN cord-267001-csgmc155 147 13 not not RB cord-267001-csgmc155 147 14 significantly significantly RB cord-267001-csgmc155 147 15 , , , cord-267001-csgmc155 147 16 as as IN cord-267001-csgmc155 147 17 compared compare VBN cord-267001-csgmc155 147 18 to to IN cord-267001-csgmc155 147 19 G4 G4 NNP cord-267001-csgmc155 147 20 . . . cord-267001-csgmc155 148 1 ( ( -LRB- cord-267001-csgmc155 148 2 Table table NN cord-267001-csgmc155 148 3 1 1 CD cord-267001-csgmc155 148 4 and and CC cord-267001-csgmc155 148 5 X x NN cord-267001-csgmc155 148 6 - - NN cord-267001-csgmc155 148 7 axis axis NN cord-267001-csgmc155 148 8 legend legend NN cord-267001-csgmc155 148 9 ) ) -RRB- cord-267001-csgmc155 148 10 . . . cord-267001-csgmc155 149 1 Sera Sera NNP cord-267001-csgmc155 149 2 samples sample NNS cord-267001-csgmc155 149 3 were be VBD cord-267001-csgmc155 149 4 collected collect VBN cord-267001-csgmc155 149 5 on on IN cord-267001-csgmc155 149 6 day day NN cord-267001-csgmc155 149 7 7 7 CD cord-267001-csgmc155 149 8 post-2nd post-2nd NN cord-267001-csgmc155 149 9 immunization immunization NN cord-267001-csgmc155 149 10 and and CC cord-267001-csgmc155 149 11 assayed assay VBN cord-267001-csgmc155 149 12 for for IN cord-267001-csgmc155 149 13 inhibition inhibition NN cord-267001-csgmc155 149 14 of of IN cord-267001-csgmc155 149 15 the the DT cord-267001-csgmc155 149 16 binding binding NN cord-267001-csgmc155 149 17 of of IN cord-267001-csgmc155 149 18 MERS MERS NNP cord-267001-csgmc155 149 19 - - HYPH cord-267001-csgmc155 149 20 CoV CoV NNP cord-267001-csgmc155 149 21 RBD RBD NNP cord-267001-csgmc155 149 22 - - HYPH cord-267001-csgmc155 149 23 Fc Fc NNP cord-267001-csgmc155 149 24 to to IN cord-267001-csgmc155 149 25 Huh-7 Huh-7 NNP cord-267001-csgmc155 149 26 cells cell NNS cord-267001-csgmc155 149 27 expressing express VBG cord-267001-csgmc155 149 28 MERS MERS NNP cord-267001-csgmc155 149 29 - - HYPH cord-267001-csgmc155 149 30 CoV CoV NNP cord-267001-csgmc155 149 31 receptor receptor NN cord-267001-csgmc155 149 32 DPP4 DPP4 NNP cord-267001-csgmc155 149 33 . . . cord-267001-csgmc155 150 1 The the DT cord-267001-csgmc155 150 2 data data NN cord-267001-csgmc155 150 3 represents represent VBZ cord-267001-csgmc155 150 4 the the DT cord-267001-csgmc155 150 5 mean mean JJ cord-267001-csgmc155 150 6 and and CC cord-267001-csgmc155 150 7 standard standard JJ cord-267001-csgmc155 150 8 error error NN cord-267001-csgmc155 150 9 ( ( -LRB- cord-267001-csgmc155 150 10 SEM SEM NNP cord-267001-csgmc155 150 11 ) ) -RRB- cord-267001-csgmc155 150 12 of of IN cord-267001-csgmc155 150 13 percentage percentage NN cord-267001-csgmc155 150 14 inhibition inhibition NN cord-267001-csgmc155 150 15 of of IN cord-267001-csgmc155 150 16 binding bind VBG cord-267001-csgmc155 150 17 from from IN cord-267001-csgmc155 150 18 at at RB cord-267001-csgmc155 150 19 least least RBS cord-267001-csgmc155 150 20 two two CD cord-267001-csgmc155 150 21 independent independent JJ cord-267001-csgmc155 150 22 experiments experiment NNS cord-267001-csgmc155 150 23 with with IN cord-267001-csgmc155 150 24 3 3 CD cord-267001-csgmc155 150 25 to to TO cord-267001-csgmc155 150 26 5 5 CD cord-267001-csgmc155 150 27 mice mouse NNS cord-267001-csgmc155 150 28 per per IN cord-267001-csgmc155 150 29 group group NN cord-267001-csgmc155 150 30 . . . cord-267001-csgmc155 151 1 " " `` cord-267001-csgmc155 151 2 + + CC cord-267001-csgmc155 151 3 " " `` cord-267001-csgmc155 151 4 indicates indicate VBZ cord-267001-csgmc155 151 5 the the DT cord-267001-csgmc155 151 6 presence presence NN cord-267001-csgmc155 151 7 and and CC cord-267001-csgmc155 151 8 " " `` cord-267001-csgmc155 151 9 − − NNP cord-267001-csgmc155 151 10 " " '' cord-267001-csgmc155 151 11 indicates indicate VBZ cord-267001-csgmc155 151 12 the the DT cord-267001-csgmc155 151 13 absence absence NN cord-267001-csgmc155 151 14 of of IN cord-267001-csgmc155 151 15 the the DT cord-267001-csgmc155 151 16 protein protein NN cord-267001-csgmc155 151 17 or or CC cord-267001-csgmc155 151 18 adjuvants adjuvant NNS cord-267001-csgmc155 151 19 in in IN cord-267001-csgmc155 151 20 the the DT cord-267001-csgmc155 151 21 formulation formulation NN cord-267001-csgmc155 151 22 . . . cord-267001-csgmc155 152 1 Statistics statistic NNS cord-267001-csgmc155 152 2 was be VBD cord-267001-csgmc155 152 3 performed perform VBN cord-267001-csgmc155 152 4 using use VBG cord-267001-csgmc155 152 5 one one CD cord-267001-csgmc155 152 6 - - HYPH cord-267001-csgmc155 152 7 way way NN cord-267001-csgmc155 152 8 ANOVA anova NN cord-267001-csgmc155 152 9 with with IN cord-267001-csgmc155 152 10 Tukey Tukey NNP cord-267001-csgmc155 152 11 's 's POS cord-267001-csgmc155 152 12 multiple multiple JJ cord-267001-csgmc155 152 13 comparison comparison NN cord-267001-csgmc155 152 14 . . . cord-267001-csgmc155 153 1 p p NN cord-267001-csgmc155 153 2 < < XX cord-267001-csgmc155 153 3 0.05 0.05 CD cord-267001-csgmc155 153 4 : : : cord-267001-csgmc155 154 1 * * NFP cord-267001-csgmc155 154 2 , , , cord-267001-csgmc155 154 3 p p NN cord-267001-csgmc155 154 4 < < XX cord-267001-csgmc155 154 5 0.0001 0.0001 CD cord-267001-csgmc155 154 6 : : : cord-267001-csgmc155 155 1 * * NFP cord-267001-csgmc155 155 2 * * NFP cord-267001-csgmc155 155 3 * * NFP cord-267001-csgmc155 155 4 * * NFP cord-267001-csgmc155 155 5 . . . cord-267001-csgmc155 155 6 ND ND NNP cord-267001-csgmc155 155 7 : : : cord-267001-csgmc155 155 8 not not RB cord-267001-csgmc155 155 9 detectable detectable JJ cord-267001-csgmc155 155 10 . . . cord-267001-csgmc155 156 1 The the DT cord-267001-csgmc155 156 2 draining drain VBG cord-267001-csgmc155 156 3 lymph lymph NN cord-267001-csgmc155 156 4 nodes node NNS cord-267001-csgmc155 156 5 ( ( -LRB- cord-267001-csgmc155 156 6 LN LN NNP cord-267001-csgmc155 156 7 ) ) -RRB- cord-267001-csgmc155 156 8 were be VBD cord-267001-csgmc155 156 9 harvested harvest VBN cord-267001-csgmc155 156 10 from from IN cord-267001-csgmc155 156 11 each each DT cord-267001-csgmc155 156 12 leg leg NN cord-267001-csgmc155 156 13 7 7 CD cord-267001-csgmc155 156 14 days day NNS cord-267001-csgmc155 156 15 post-2nd post-2nd JJ cord-267001-csgmc155 156 16 immunization immunization NN cord-267001-csgmc155 156 17 and and CC cord-267001-csgmc155 156 18 analyzed analyze VBN cord-267001-csgmc155 156 19 for for IN cord-267001-csgmc155 156 20 the the DT cord-267001-csgmc155 156 21 number number NN cord-267001-csgmc155 156 22 of of IN cord-267001-csgmc155 156 23 monocytes monocyte NNS cord-267001-csgmc155 156 24 as as RB cord-267001-csgmc155 156 25 well well RB cord-267001-csgmc155 156 26 as as IN cord-267001-csgmc155 156 27 their -PRON- PRP$ cord-267001-csgmc155 156 28 activation activation NN cord-267001-csgmc155 156 29 and and CC cord-267001-csgmc155 156 30 migratory migratory JJ cord-267001-csgmc155 156 31 status status NN cord-267001-csgmc155 156 32 . . . cord-267001-csgmc155 157 1 Migration migration NN cord-267001-csgmc155 157 2 of of IN cord-267001-csgmc155 157 3 innate innate JJ cord-267001-csgmc155 157 4 cells cell NNS cord-267001-csgmc155 157 5 from from IN cord-267001-csgmc155 157 6 the the DT cord-267001-csgmc155 157 7 site site NN cord-267001-csgmc155 157 8 of of IN cord-267001-csgmc155 157 9 injection injection NN cord-267001-csgmc155 157 10 to to IN cord-267001-csgmc155 157 11 the the DT cord-267001-csgmc155 157 12 LNs ln NNS cord-267001-csgmc155 157 13 are be VBP cord-267001-csgmc155 157 14 required require VBN cord-267001-csgmc155 157 15 to to TO cord-267001-csgmc155 157 16 initiate initiate VB cord-267001-csgmc155 157 17 an an DT cord-267001-csgmc155 157 18 effective effective JJ cord-267001-csgmc155 157 19 adaptive adaptive JJ cord-267001-csgmc155 157 20 immune immune JJ cord-267001-csgmc155 157 21 response response NN cord-267001-csgmc155 157 22 [ [ -LRB- cord-267001-csgmc155 157 23 27 27 CD cord-267001-csgmc155 157 24 ] ] -RRB- cord-267001-csgmc155 157 25 . . . cord-267001-csgmc155 158 1 The the DT cord-267001-csgmc155 158 2 analyses analysis NNS cord-267001-csgmc155 158 3 demonstrated demonstrate VBD cord-267001-csgmc155 158 4 that that IN cord-267001-csgmc155 158 5 there there EX cord-267001-csgmc155 158 6 was be VBD cord-267001-csgmc155 158 7 no no DT cord-267001-csgmc155 158 8 significant significant JJ cord-267001-csgmc155 158 9 difference difference NN cord-267001-csgmc155 158 10 in in IN cord-267001-csgmc155 158 11 the the DT cord-267001-csgmc155 158 12 total total JJ cord-267001-csgmc155 158 13 number number NN cord-267001-csgmc155 158 14 of of IN cord-267001-csgmc155 158 15 monocytes monocyte NNS cord-267001-csgmc155 158 16 ( ( -LRB- cord-267001-csgmc155 158 17 CD45 CD45 NNP cord-267001-csgmc155 158 18 + + CC cord-267001-csgmc155 158 19 CD11c CD11c NNP cord-267001-csgmc155 158 20 -Ly6C -Ly6C NNP cord-267001-csgmc155 158 21 + + CC cord-267001-csgmc155 158 22 ; ; : cord-267001-csgmc155 158 23 Figures figure NNS cord-267001-csgmc155 158 24 S2A s2a JJ cord-267001-csgmc155 158 25 and and CC cord-267001-csgmc155 158 26 S3A s3a LS cord-267001-csgmc155 158 27 ) ) -RRB- cord-267001-csgmc155 158 28 recruited recruit VBN cord-267001-csgmc155 158 29 into into IN cord-267001-csgmc155 158 30 the the DT cord-267001-csgmc155 158 31 LN ln NN cord-267001-csgmc155 158 32 per per IN cord-267001-csgmc155 158 33 mouse mouse NN cord-267001-csgmc155 158 34 between between IN cord-267001-csgmc155 158 35 the the DT cord-267001-csgmc155 158 36 various various JJ cord-267001-csgmc155 158 37 immunization immunization NN cord-267001-csgmc155 158 38 groups group NNS cord-267001-csgmc155 158 39 . . . cord-267001-csgmc155 159 1 However however RB cord-267001-csgmc155 159 2 , , , cord-267001-csgmc155 159 3 the the DT cord-267001-csgmc155 159 4 number number NN cord-267001-csgmc155 159 5 of of IN cord-267001-csgmc155 159 6 activated activate VBN cord-267001-csgmc155 159 7 monocytes monocyte NNS cord-267001-csgmc155 159 8 ( ( -LRB- cord-267001-csgmc155 159 9 C45 C45 NNP cord-267001-csgmc155 159 10 + + CC cord-267001-csgmc155 159 11 CD11c CD11c NNP cord-267001-csgmc155 159 12 -Ly6C -Ly6C NNP cord-267001-csgmc155 159 13 + + CC cord-267001-csgmc155 159 14 CD40 CD40 NNP cord-267001-csgmc155 159 15 + + CC cord-267001-csgmc155 159 16 ) ) -RRB- cord-267001-csgmc155 159 17 in in IN cord-267001-csgmc155 159 18 the the DT cord-267001-csgmc155 159 19 LN LN NNP cord-267001-csgmc155 159 20 were be VBD cord-267001-csgmc155 159 21 significantly significantly RB cord-267001-csgmc155 159 22 higher high JJR cord-267001-csgmc155 159 23 in in IN cord-267001-csgmc155 159 24 mice mouse NNS cord-267001-csgmc155 159 25 where where WRB cord-267001-csgmc155 159 26 rASP-1 rasp-1 NN cord-267001-csgmc155 159 27 and and CC cord-267001-csgmc155 159 28 the the DT cord-267001-csgmc155 159 29 alumadjuvanted alumadjuvanted JJ cord-267001-csgmc155 159 30 RBD RBD NNP cord-267001-csgmc155 159 31 vaccine vaccine NN cord-267001-csgmc155 159 32 were be VBD cord-267001-csgmc155 159 33 co co VBN cord-267001-csgmc155 159 34 - - VBN cord-267001-csgmc155 159 35 administered administer VBN cord-267001-csgmc155 159 36 in in IN cord-267001-csgmc155 159 37 separate separate JJ cord-267001-csgmc155 159 38 sites site NNS cord-267001-csgmc155 159 39 than than IN cord-267001-csgmc155 159 40 in in IN cord-267001-csgmc155 159 41 mice mouse NNS cord-267001-csgmc155 159 42 immunized immunize VBN cord-267001-csgmc155 159 43 with with IN cord-267001-csgmc155 159 44 RBD RBD NNP cord-267001-csgmc155 159 45 + + CC cord-267001-csgmc155 160 1 rASP-1 rasp-1 LS cord-267001-csgmc155 160 2 + + CC cord-267001-csgmc155 160 3 alum alum NN cord-267001-csgmc155 160 4 in in IN cord-267001-csgmc155 160 5 a a DT cord-267001-csgmc155 160 6 single single JJ cord-267001-csgmc155 160 7 inoculum inoculum NN cord-267001-csgmc155 160 8 , , , cord-267001-csgmc155 160 9 or or CC cord-267001-csgmc155 160 10 with with IN cord-267001-csgmc155 160 11 alum alum NN cord-267001-csgmc155 160 12 - - HYPH cord-267001-csgmc155 160 13 adjuvanted adjuvante VBN cord-267001-csgmc155 160 14 RBD RBD NNP cord-267001-csgmc155 160 15 vaccine vaccine NN cord-267001-csgmc155 160 16 ( ( -LRB- cord-267001-csgmc155 160 17 G6 G6 NNP cord-267001-csgmc155 160 18 vs. vs. IN cord-267001-csgmc155 160 19 G5 G5 NNP cord-267001-csgmc155 160 20 and and CC cord-267001-csgmc155 160 21 G4 G4 NNP cord-267001-csgmc155 160 22 , , , cord-267001-csgmc155 160 23 respectively respectively RB cord-267001-csgmc155 160 24 ; ; : cord-267001-csgmc155 160 25 Figure figure NN cord-267001-csgmc155 160 26 3B 3b CD cord-267001-csgmc155 160 27 ) ) -RRB- cord-267001-csgmc155 160 28 . . . cord-267001-csgmc155 161 1 Notably notably RB cord-267001-csgmc155 161 2 , , , cord-267001-csgmc155 161 3 the the DT cord-267001-csgmc155 161 4 number number NN cord-267001-csgmc155 161 5 of of IN cord-267001-csgmc155 161 6 activated activate VBN cord-267001-csgmc155 161 7 monocytes monocyte NNS cord-267001-csgmc155 161 8 in in IN cord-267001-csgmc155 161 9 the the DT cord-267001-csgmc155 161 10 LN ln NN cord-267001-csgmc155 161 11 of of IN cord-267001-csgmc155 161 12 mice mouse NNS cord-267001-csgmc155 161 13 that that WDT cord-267001-csgmc155 161 14 received receive VBD cord-267001-csgmc155 161 15 only only RB cord-267001-csgmc155 161 16 the the DT cord-267001-csgmc155 161 17 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 161 18 RBD RBD NNP cord-267001-csgmc155 161 19 vaccine vaccine NN cord-267001-csgmc155 161 20 ( ( -LRB- cord-267001-csgmc155 161 21 G3 G3 NNP cord-267001-csgmc155 161 22 ) ) -RRB- cord-267001-csgmc155 161 23 were be VBD cord-267001-csgmc155 161 24 similar similar JJ cord-267001-csgmc155 161 25 to to IN cord-267001-csgmc155 161 26 those those DT cord-267001-csgmc155 161 27 present present JJ cord-267001-csgmc155 161 28 in in IN cord-267001-csgmc155 161 29 mice mouse NNS cord-267001-csgmc155 161 30 where where WRB cord-267001-csgmc155 161 31 rASP-1 rASP-1 NNP cord-267001-csgmc155 161 32 was be VBD cord-267001-csgmc155 161 33 administered administer VBN cord-267001-csgmc155 161 34 without without IN cord-267001-csgmc155 161 35 being be VBG cord-267001-csgmc155 161 36 adsorbed adsorb VBN cord-267001-csgmc155 161 37 to to IN cord-267001-csgmc155 161 38 alum alum NN cord-267001-csgmc155 161 39 ( ( -LRB- cord-267001-csgmc155 161 40 G6 G6 NNP cord-267001-csgmc155 161 41 ) ) -RRB- cord-267001-csgmc155 161 42 . . . cord-267001-csgmc155 162 1 It -PRON- PRP cord-267001-csgmc155 162 2 appears appear VBZ cord-267001-csgmc155 162 3 that that DT cord-267001-csgmc155 162 4 alum alum NN cord-267001-csgmc155 162 5 does do VBZ cord-267001-csgmc155 162 6 not not RB cord-267001-csgmc155 162 7 add add VB cord-267001-csgmc155 162 8 to to IN cord-267001-csgmc155 162 9 the the DT cord-267001-csgmc155 162 10 activation activation NN cord-267001-csgmc155 162 11 of of IN cord-267001-csgmc155 162 12 the the DT cord-267001-csgmc155 162 13 monocytes monocyte NNS cord-267001-csgmc155 162 14 in in IN cord-267001-csgmc155 162 15 any any DT cord-267001-csgmc155 162 16 of of IN cord-267001-csgmc155 162 17 the the DT cord-267001-csgmc155 162 18 formulations formulation NNS cord-267001-csgmc155 162 19 tested test VBN cord-267001-csgmc155 162 20 ( ( -LRB- cord-267001-csgmc155 162 21 G4 G4 NNP cord-267001-csgmc155 162 22 , , , cord-267001-csgmc155 162 23 G5 G5 NNP cord-267001-csgmc155 162 24 or or CC cord-267001-csgmc155 162 25 G6 G6 NNP cord-267001-csgmc155 162 26 ; ; : cord-267001-csgmc155 162 27 Figure figure NN cord-267001-csgmc155 162 28 3B 3b CD cord-267001-csgmc155 162 29 ) ) -RRB- cord-267001-csgmc155 162 30 . . . cord-267001-csgmc155 163 1 ( ( -LRB- cord-267001-csgmc155 163 2 Table table NN cord-267001-csgmc155 163 3 1 1 CD cord-267001-csgmc155 163 4 and and CC cord-267001-csgmc155 163 5 X x NN cord-267001-csgmc155 163 6 - - NN cord-267001-csgmc155 163 7 axis axis NN cord-267001-csgmc155 163 8 legend legend NN cord-267001-csgmc155 163 9 ) ) -RRB- cord-267001-csgmc155 163 10 . . . cord-267001-csgmc155 164 1 Sera Sera NNP cord-267001-csgmc155 164 2 samples sample NNS cord-267001-csgmc155 164 3 were be VBD cord-267001-csgmc155 164 4 collected collect VBN cord-267001-csgmc155 164 5 on on IN cord-267001-csgmc155 164 6 day day NN cord-267001-csgmc155 164 7 7 7 CD cord-267001-csgmc155 164 8 post-2nd post-2nd NN cord-267001-csgmc155 164 9 immunization immunization NN cord-267001-csgmc155 164 10 and and CC cord-267001-csgmc155 164 11 assayed assay VBN cord-267001-csgmc155 164 12 for for IN cord-267001-csgmc155 164 13 inhibition inhibition NN cord-267001-csgmc155 164 14 of of IN cord-267001-csgmc155 164 15 the the DT cord-267001-csgmc155 164 16 binding binding NN cord-267001-csgmc155 164 17 of of IN cord-267001-csgmc155 164 18 MERS MERS NNP cord-267001-csgmc155 164 19 - - HYPH cord-267001-csgmc155 164 20 CoV CoV NNP cord-267001-csgmc155 164 21 RBD RBD NNP cord-267001-csgmc155 164 22 - - HYPH cord-267001-csgmc155 164 23 Fc Fc NNP cord-267001-csgmc155 164 24 to to IN cord-267001-csgmc155 164 25 Huh-7 Huh-7 NNP cord-267001-csgmc155 164 26 cells cell NNS cord-267001-csgmc155 164 27 expressing express VBG cord-267001-csgmc155 164 28 MERS MERS NNP cord-267001-csgmc155 164 29 - - HYPH cord-267001-csgmc155 164 30 CoV CoV NNP cord-267001-csgmc155 164 31 receptor receptor NN cord-267001-csgmc155 164 32 DPP4 DPP4 NNP cord-267001-csgmc155 164 33 . . . cord-267001-csgmc155 165 1 The the DT cord-267001-csgmc155 165 2 data data NN cord-267001-csgmc155 165 3 represents represent VBZ cord-267001-csgmc155 165 4 the the DT cord-267001-csgmc155 165 5 mean mean JJ cord-267001-csgmc155 165 6 and and CC cord-267001-csgmc155 165 7 standard standard JJ cord-267001-csgmc155 165 8 error error NN cord-267001-csgmc155 165 9 ( ( -LRB- cord-267001-csgmc155 165 10 SEM SEM NNP cord-267001-csgmc155 165 11 ) ) -RRB- cord-267001-csgmc155 165 12 of of IN cord-267001-csgmc155 165 13 percentage percentage NN cord-267001-csgmc155 165 14 inhibition inhibition NN cord-267001-csgmc155 165 15 of of IN cord-267001-csgmc155 165 16 binding bind VBG cord-267001-csgmc155 165 17 from from IN cord-267001-csgmc155 165 18 at at RB cord-267001-csgmc155 165 19 least least RBS cord-267001-csgmc155 165 20 two two CD cord-267001-csgmc155 165 21 independent independent JJ cord-267001-csgmc155 165 22 experiments experiment NNS cord-267001-csgmc155 165 23 with with IN cord-267001-csgmc155 165 24 3 3 CD cord-267001-csgmc155 165 25 to to TO cord-267001-csgmc155 165 26 5 5 CD cord-267001-csgmc155 165 27 mice mouse NNS cord-267001-csgmc155 165 28 per per IN cord-267001-csgmc155 165 29 group group NN cord-267001-csgmc155 165 30 . . . cord-267001-csgmc155 166 1 " " `` cord-267001-csgmc155 166 2 + + CC cord-267001-csgmc155 166 3 " " `` cord-267001-csgmc155 166 4 indicates indicate VBZ cord-267001-csgmc155 166 5 the the DT cord-267001-csgmc155 166 6 presence presence NN cord-267001-csgmc155 166 7 and and CC cord-267001-csgmc155 166 8 " " `` cord-267001-csgmc155 166 9 − − NNP cord-267001-csgmc155 166 10 " " '' cord-267001-csgmc155 166 11 indicates indicate VBZ cord-267001-csgmc155 166 12 the the DT cord-267001-csgmc155 166 13 absence absence NN cord-267001-csgmc155 166 14 of of IN cord-267001-csgmc155 166 15 the the DT cord-267001-csgmc155 166 16 protein protein NN cord-267001-csgmc155 166 17 or or CC cord-267001-csgmc155 166 18 adjuvants adjuvant NNS cord-267001-csgmc155 166 19 in in IN cord-267001-csgmc155 166 20 the the DT cord-267001-csgmc155 166 21 formulation formulation NN cord-267001-csgmc155 166 22 . . . cord-267001-csgmc155 167 1 Statistics statistic NNS cord-267001-csgmc155 167 2 was be VBD cord-267001-csgmc155 167 3 performed perform VBN cord-267001-csgmc155 167 4 using use VBG cord-267001-csgmc155 167 5 one one CD cord-267001-csgmc155 167 6 - - HYPH cord-267001-csgmc155 167 7 way way NN cord-267001-csgmc155 167 8 ANOVA anova NN cord-267001-csgmc155 167 9 with with IN cord-267001-csgmc155 167 10 Tukey Tukey NNP cord-267001-csgmc155 167 11 's 's POS cord-267001-csgmc155 167 12 multiple multiple JJ cord-267001-csgmc155 167 13 comparison comparison NN cord-267001-csgmc155 167 14 . . . cord-267001-csgmc155 168 1 p p NN cord-267001-csgmc155 168 2 < < XX cord-267001-csgmc155 168 3 0.05 0.05 CD cord-267001-csgmc155 168 4 : : : cord-267001-csgmc155 169 1 * * NFP cord-267001-csgmc155 169 2 , , , cord-267001-csgmc155 169 3 p p NN cord-267001-csgmc155 169 4 < < XX cord-267001-csgmc155 169 5 0.0001 0.0001 CD cord-267001-csgmc155 169 6 : : : cord-267001-csgmc155 170 1 * * NFP cord-267001-csgmc155 170 2 * * NFP cord-267001-csgmc155 170 3 * * NFP cord-267001-csgmc155 170 4 * * NFP cord-267001-csgmc155 170 5 . . . cord-267001-csgmc155 170 6 ND ND NNP cord-267001-csgmc155 170 7 : : : cord-267001-csgmc155 170 8 not not RB cord-267001-csgmc155 170 9 detectable detectable JJ cord-267001-csgmc155 170 10 . . . cord-267001-csgmc155 171 1 The the DT cord-267001-csgmc155 171 2 draining drain VBG cord-267001-csgmc155 171 3 lymph lymph NN cord-267001-csgmc155 171 4 nodes node NNS cord-267001-csgmc155 171 5 ( ( -LRB- cord-267001-csgmc155 171 6 LN LN NNP cord-267001-csgmc155 171 7 ) ) -RRB- cord-267001-csgmc155 171 8 were be VBD cord-267001-csgmc155 171 9 harvested harvest VBN cord-267001-csgmc155 171 10 from from IN cord-267001-csgmc155 171 11 each each DT cord-267001-csgmc155 171 12 leg leg NN cord-267001-csgmc155 171 13 7 7 CD cord-267001-csgmc155 171 14 days day NNS cord-267001-csgmc155 171 15 post-2nd post-2nd JJ cord-267001-csgmc155 171 16 immunization immunization NN cord-267001-csgmc155 171 17 and and CC cord-267001-csgmc155 171 18 analyzed analyze VBN cord-267001-csgmc155 171 19 for for IN cord-267001-csgmc155 171 20 the the DT cord-267001-csgmc155 171 21 number number NN cord-267001-csgmc155 171 22 of of IN cord-267001-csgmc155 171 23 monocytes monocyte NNS cord-267001-csgmc155 171 24 as as RB cord-267001-csgmc155 171 25 well well RB cord-267001-csgmc155 171 26 as as IN cord-267001-csgmc155 171 27 their -PRON- PRP$ cord-267001-csgmc155 171 28 activation activation NN cord-267001-csgmc155 171 29 and and CC cord-267001-csgmc155 171 30 migratory migratory JJ cord-267001-csgmc155 171 31 status status NN cord-267001-csgmc155 171 32 . . . cord-267001-csgmc155 172 1 Migration migration NN cord-267001-csgmc155 172 2 of of IN cord-267001-csgmc155 172 3 innate innate JJ cord-267001-csgmc155 172 4 cells cell NNS cord-267001-csgmc155 172 5 from from IN cord-267001-csgmc155 172 6 the the DT cord-267001-csgmc155 172 7 site site NN cord-267001-csgmc155 172 8 of of IN cord-267001-csgmc155 172 9 injection injection NN cord-267001-csgmc155 172 10 to to IN cord-267001-csgmc155 172 11 the the DT cord-267001-csgmc155 172 12 LNs ln NNS cord-267001-csgmc155 172 13 are be VBP cord-267001-csgmc155 172 14 required require VBN cord-267001-csgmc155 172 15 to to TO cord-267001-csgmc155 172 16 initiate initiate VB cord-267001-csgmc155 172 17 an an DT cord-267001-csgmc155 172 18 effective effective JJ cord-267001-csgmc155 172 19 adaptive adaptive JJ cord-267001-csgmc155 172 20 immune immune JJ cord-267001-csgmc155 172 21 response response NN cord-267001-csgmc155 172 22 [ [ -LRB- cord-267001-csgmc155 172 23 27 27 CD cord-267001-csgmc155 172 24 ] ] -RRB- cord-267001-csgmc155 172 25 . . . cord-267001-csgmc155 173 1 The the DT cord-267001-csgmc155 173 2 analyses analysis NNS cord-267001-csgmc155 173 3 demonstrated demonstrate VBD cord-267001-csgmc155 173 4 that that IN cord-267001-csgmc155 173 5 there there EX cord-267001-csgmc155 173 6 was be VBD cord-267001-csgmc155 173 7 no no DT cord-267001-csgmc155 173 8 significant significant JJ cord-267001-csgmc155 173 9 difference difference NN cord-267001-csgmc155 173 10 in in IN cord-267001-csgmc155 173 11 the the DT cord-267001-csgmc155 173 12 total total JJ cord-267001-csgmc155 173 13 number number NN cord-267001-csgmc155 173 14 of of IN cord-267001-csgmc155 173 15 monocytes monocyte NNS cord-267001-csgmc155 173 16 ( ( -LRB- cord-267001-csgmc155 173 17 CD45 CD45 NNP cord-267001-csgmc155 173 18 + + CC cord-267001-csgmc155 173 19 CD11c CD11c NNP cord-267001-csgmc155 173 20 -Ly6C -Ly6C NNP cord-267001-csgmc155 173 21 + + CC cord-267001-csgmc155 173 22 ; ; : cord-267001-csgmc155 173 23 Figures figure NNS cord-267001-csgmc155 173 24 S2A s2a JJ cord-267001-csgmc155 173 25 and and CC cord-267001-csgmc155 173 26 S3A s3a LS cord-267001-csgmc155 173 27 ) ) -RRB- cord-267001-csgmc155 173 28 recruited recruit VBN cord-267001-csgmc155 173 29 into into IN cord-267001-csgmc155 173 30 the the DT cord-267001-csgmc155 173 31 LN ln NN cord-267001-csgmc155 173 32 per per IN cord-267001-csgmc155 173 33 mouse mouse NN cord-267001-csgmc155 173 34 between between IN cord-267001-csgmc155 173 35 the the DT cord-267001-csgmc155 173 36 various various JJ cord-267001-csgmc155 173 37 immunization immunization NN cord-267001-csgmc155 173 38 groups group NNS cord-267001-csgmc155 173 39 . . . cord-267001-csgmc155 174 1 However however RB cord-267001-csgmc155 174 2 , , , cord-267001-csgmc155 174 3 the the DT cord-267001-csgmc155 174 4 number number NN cord-267001-csgmc155 174 5 of of IN cord-267001-csgmc155 174 6 activated activate VBN cord-267001-csgmc155 174 7 monocytes monocyte NNS cord-267001-csgmc155 174 8 ( ( -LRB- cord-267001-csgmc155 174 9 C45 C45 NNP cord-267001-csgmc155 174 10 + + CC cord-267001-csgmc155 174 11 CD11c CD11c NNP cord-267001-csgmc155 174 12 -Ly6C -Ly6C NNP cord-267001-csgmc155 174 13 + + CC cord-267001-csgmc155 174 14 CD40 CD40 NNP cord-267001-csgmc155 174 15 + + CC cord-267001-csgmc155 174 16 ) ) -RRB- cord-267001-csgmc155 174 17 in in IN cord-267001-csgmc155 174 18 the the DT cord-267001-csgmc155 174 19 LN LN NNP cord-267001-csgmc155 174 20 were be VBD cord-267001-csgmc155 174 21 significantly significantly RB cord-267001-csgmc155 174 22 higher high JJR cord-267001-csgmc155 174 23 in in IN cord-267001-csgmc155 174 24 mice mouse NNS cord-267001-csgmc155 174 25 where where WRB cord-267001-csgmc155 174 26 rASP-1 rasp-1 NN cord-267001-csgmc155 174 27 and and CC cord-267001-csgmc155 174 28 the the DT cord-267001-csgmc155 174 29 alum alum NN cord-267001-csgmc155 174 30 - - HYPH cord-267001-csgmc155 174 31 adjuvanted adjuvante VBN cord-267001-csgmc155 174 32 RBD RBD NNP cord-267001-csgmc155 174 33 vaccine vaccine NN cord-267001-csgmc155 174 34 were be VBD cord-267001-csgmc155 174 35 co co VBN cord-267001-csgmc155 174 36 - - VBN cord-267001-csgmc155 174 37 administered administer VBN cord-267001-csgmc155 174 38 in in IN cord-267001-csgmc155 174 39 separate separate JJ cord-267001-csgmc155 174 40 sites site NNS cord-267001-csgmc155 174 41 than than IN cord-267001-csgmc155 174 42 in in IN cord-267001-csgmc155 174 43 mice mouse NNS cord-267001-csgmc155 174 44 immunized immunize VBN cord-267001-csgmc155 174 45 with with IN cord-267001-csgmc155 174 46 RBD RBD NNP cord-267001-csgmc155 174 47 + + CC cord-267001-csgmc155 175 1 rASP-1 rasp-1 LS cord-267001-csgmc155 175 2 + + CC cord-267001-csgmc155 175 3 alum alum NN cord-267001-csgmc155 175 4 in in IN cord-267001-csgmc155 175 5 a a DT cord-267001-csgmc155 175 6 single single JJ cord-267001-csgmc155 175 7 inoculum inoculum NN cord-267001-csgmc155 175 8 , , , cord-267001-csgmc155 175 9 or or CC cord-267001-csgmc155 175 10 with with IN cord-267001-csgmc155 175 11 alum alum NN cord-267001-csgmc155 175 12 - - HYPH cord-267001-csgmc155 175 13 adjuvanted adjuvante VBN cord-267001-csgmc155 175 14 RBD RBD NNP cord-267001-csgmc155 175 15 vaccine vaccine NN cord-267001-csgmc155 175 16 ( ( -LRB- cord-267001-csgmc155 175 17 G6 G6 NNP cord-267001-csgmc155 175 18 vs. vs. IN cord-267001-csgmc155 175 19 G5 G5 NNP cord-267001-csgmc155 175 20 and and CC cord-267001-csgmc155 175 21 G4 G4 NNP cord-267001-csgmc155 175 22 , , , cord-267001-csgmc155 175 23 respectively respectively RB cord-267001-csgmc155 175 24 ; ; : cord-267001-csgmc155 175 25 Figure figure NN cord-267001-csgmc155 175 26 3B 3b CD cord-267001-csgmc155 175 27 ) ) -RRB- cord-267001-csgmc155 175 28 . . . cord-267001-csgmc155 176 1 Notably notably RB cord-267001-csgmc155 176 2 , , , cord-267001-csgmc155 176 3 the the DT cord-267001-csgmc155 176 4 number number NN cord-267001-csgmc155 176 5 of of IN cord-267001-csgmc155 176 6 activated activate VBN cord-267001-csgmc155 176 7 monocytes monocyte NNS cord-267001-csgmc155 176 8 in in IN cord-267001-csgmc155 176 9 the the DT cord-267001-csgmc155 176 10 LN ln NN cord-267001-csgmc155 176 11 of of IN cord-267001-csgmc155 176 12 mice mouse NNS cord-267001-csgmc155 176 13 that that WDT cord-267001-csgmc155 176 14 received receive VBD cord-267001-csgmc155 176 15 only only RB cord-267001-csgmc155 176 16 the the DT cord-267001-csgmc155 176 17 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 176 18 RBD RBD NNP cord-267001-csgmc155 176 19 vaccine vaccine NN cord-267001-csgmc155 176 20 ( ( -LRB- cord-267001-csgmc155 176 21 G3 G3 NNP cord-267001-csgmc155 176 22 ) ) -RRB- cord-267001-csgmc155 176 23 were be VBD cord-267001-csgmc155 176 24 similar similar JJ cord-267001-csgmc155 176 25 to to IN cord-267001-csgmc155 176 26 those those DT cord-267001-csgmc155 176 27 present present JJ cord-267001-csgmc155 176 28 in in IN cord-267001-csgmc155 176 29 mice mouse NNS cord-267001-csgmc155 176 30 where where WRB cord-267001-csgmc155 176 31 rASP-1 rASP-1 NNP cord-267001-csgmc155 176 32 was be VBD cord-267001-csgmc155 176 33 administered administer VBN cord-267001-csgmc155 176 34 without without IN cord-267001-csgmc155 176 35 being be VBG cord-267001-csgmc155 176 36 adsorbed adsorb VBN cord-267001-csgmc155 176 37 to to IN cord-267001-csgmc155 176 38 alum alum NN cord-267001-csgmc155 176 39 ( ( -LRB- cord-267001-csgmc155 176 40 G6 G6 NNP cord-267001-csgmc155 176 41 ) ) -RRB- cord-267001-csgmc155 176 42 . . . cord-267001-csgmc155 177 1 It -PRON- PRP cord-267001-csgmc155 177 2 appears appear VBZ cord-267001-csgmc155 177 3 that that DT cord-267001-csgmc155 177 4 alum alum NN cord-267001-csgmc155 177 5 does do VBZ cord-267001-csgmc155 177 6 not not RB cord-267001-csgmc155 177 7 add add VB cord-267001-csgmc155 177 8 to to IN cord-267001-csgmc155 177 9 the the DT cord-267001-csgmc155 177 10 activation activation NN cord-267001-csgmc155 177 11 of of IN cord-267001-csgmc155 177 12 the the DT cord-267001-csgmc155 177 13 monocytes monocyte NNS cord-267001-csgmc155 177 14 in in IN cord-267001-csgmc155 177 15 any any DT cord-267001-csgmc155 177 16 of of IN cord-267001-csgmc155 177 17 the the DT cord-267001-csgmc155 177 18 formulations formulation NNS cord-267001-csgmc155 177 19 tested test VBN cord-267001-csgmc155 177 20 ( ( -LRB- cord-267001-csgmc155 177 21 G4 G4 NNP cord-267001-csgmc155 177 22 , , , cord-267001-csgmc155 177 23 G5 G5 NNP cord-267001-csgmc155 177 24 or or CC cord-267001-csgmc155 177 25 G6 G6 NNP cord-267001-csgmc155 177 26 ; ; : cord-267001-csgmc155 177 27 Figure figure NN cord-267001-csgmc155 177 28 3B 3b CD cord-267001-csgmc155 177 29 ) ) -RRB- cord-267001-csgmc155 177 30 . . . cord-267001-csgmc155 178 1 Nevertheless nevertheless RB cord-267001-csgmc155 178 2 , , , cord-267001-csgmc155 178 3 a a DT cord-267001-csgmc155 178 4 synergistic synergistic JJ cord-267001-csgmc155 178 5 effect effect NN cord-267001-csgmc155 178 6 was be VBD cord-267001-csgmc155 178 7 observed observe VBN cord-267001-csgmc155 178 8 when when WRB cord-267001-csgmc155 178 9 rASP-1 rASP-1 NNP cord-267001-csgmc155 178 10 was be VBD cord-267001-csgmc155 178 11 added add VBN cord-267001-csgmc155 178 12 to to IN cord-267001-csgmc155 178 13 the the DT cord-267001-csgmc155 178 14 RBD RBD NNP cord-267001-csgmc155 178 15 vaccine vaccine NN cord-267001-csgmc155 178 16 with with IN cord-267001-csgmc155 178 17 or or CC cord-267001-csgmc155 178 18 without without IN cord-267001-csgmc155 178 19 alum alum NN cord-267001-csgmc155 178 20 with with IN cord-267001-csgmc155 178 21 respect respect NN cord-267001-csgmc155 178 22 to to IN cord-267001-csgmc155 178 23 CCR7 CCR7 NNP cord-267001-csgmc155 179 1 + + CC cord-267001-csgmc155 179 2 ( ( -LRB- cord-267001-csgmc155 179 3 migratory migratory JJ cord-267001-csgmc155 179 4 ) ) -RRB- cord-267001-csgmc155 179 5 monocyte monocyte NNP cord-267001-csgmc155 179 6 subset subset NNP cord-267001-csgmc155 179 7 . . . cord-267001-csgmc155 180 1 The the DT cord-267001-csgmc155 180 2 number number NN cord-267001-csgmc155 180 3 of of IN cord-267001-csgmc155 180 4 migratory migratory JJ cord-267001-csgmc155 180 5 monocytes monocyte NNS cord-267001-csgmc155 180 6 ( ( -LRB- cord-267001-csgmc155 180 7 CD45 CD45 NNP cord-267001-csgmc155 180 8 + + CC cord-267001-csgmc155 180 9 CD11c CD11c NNP cord-267001-csgmc155 180 10 -Ly6C -Ly6C NNP cord-267001-csgmc155 180 11 + + CC cord-267001-csgmc155 180 12 CCR7 CCR7 NNP cord-267001-csgmc155 180 13 + + CC cord-267001-csgmc155 180 14 ) ) -RRB- cord-267001-csgmc155 180 15 in in IN cord-267001-csgmc155 180 16 the the DT cord-267001-csgmc155 180 17 LN LN NNP cord-267001-csgmc155 180 18 were be VBD cord-267001-csgmc155 180 19 significantly significantly RB cord-267001-csgmc155 180 20 higher high JJR cord-267001-csgmc155 180 21 in in IN cord-267001-csgmc155 180 22 mice mouse NNS cord-267001-csgmc155 180 23 where where WRB cord-267001-csgmc155 180 24 rASP-1 rasp-1 NN cord-267001-csgmc155 180 25 and and CC cord-267001-csgmc155 180 26 the the DT cord-267001-csgmc155 180 27 alum alum NN cord-267001-csgmc155 180 28 - - HYPH cord-267001-csgmc155 180 29 adjuvanted adjuvante VBN cord-267001-csgmc155 180 30 RBD RBD NNP cord-267001-csgmc155 180 31 vaccine vaccine NN cord-267001-csgmc155 180 32 were be VBD cord-267001-csgmc155 180 33 co co VBN cord-267001-csgmc155 180 34 - - VBN cord-267001-csgmc155 180 35 administered administer VBN cord-267001-csgmc155 180 36 in in IN cord-267001-csgmc155 180 37 separate separate JJ cord-267001-csgmc155 180 38 sites site NNS cord-267001-csgmc155 180 39 , , , cord-267001-csgmc155 180 40 RBD RBD NNP cord-267001-csgmc155 180 41 + + CC cord-267001-csgmc155 180 42 rASP-1 rasp-1 NN cord-267001-csgmc155 180 43 + + CC cord-267001-csgmc155 180 44 alum alum NN cord-267001-csgmc155 180 45 was be VBD cord-267001-csgmc155 180 46 administered administer VBN cord-267001-csgmc155 180 47 in in IN cord-267001-csgmc155 180 48 a a DT cord-267001-csgmc155 180 49 single single JJ cord-267001-csgmc155 180 50 inoculum inoculum NN cord-267001-csgmc155 180 51 or or CC cord-267001-csgmc155 180 52 the the DT cord-267001-csgmc155 180 53 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 180 54 RBD RBD NNP cord-267001-csgmc155 180 55 vaccine vaccine NN cord-267001-csgmc155 180 56 vs. vs. IN cord-267001-csgmc155 180 57 the the DT cord-267001-csgmc155 180 58 alum alum NN cord-267001-csgmc155 180 59 - - HYPH cord-267001-csgmc155 180 60 adjuvanted adjuvante VBN cord-267001-csgmc155 180 61 RBD RBD NNP cord-267001-csgmc155 180 62 vaccine vaccine NN cord-267001-csgmc155 180 63 ( ( -LRB- cord-267001-csgmc155 180 64 G6 G6 NNP cord-267001-csgmc155 180 65 , , , cord-267001-csgmc155 180 66 G5 G5 NNP cord-267001-csgmc155 180 67 and and CC cord-267001-csgmc155 180 68 G3 G3 NNP cord-267001-csgmc155 180 69 vs. vs. IN cord-267001-csgmc155 180 70 G4 G4 NNP cord-267001-csgmc155 180 71 ; ; : cord-267001-csgmc155 180 72 Figure Figure NNP cord-267001-csgmc155 180 73 3C 3c NN cord-267001-csgmc155 180 74 ) ) -RRB- cord-267001-csgmc155 180 75 . . . cord-267001-csgmc155 181 1 The the DT cord-267001-csgmc155 181 2 number number NN cord-267001-csgmc155 181 3 of of IN cord-267001-csgmc155 181 4 migratory migratory JJ cord-267001-csgmc155 181 5 monocytes monocyte NNS cord-267001-csgmc155 181 6 in in IN cord-267001-csgmc155 181 7 the the DT cord-267001-csgmc155 181 8 LN ln NN cord-267001-csgmc155 181 9 of of IN cord-267001-csgmc155 181 10 mice mouse NNS cord-267001-csgmc155 181 11 that that WDT cord-267001-csgmc155 181 12 received receive VBD cord-267001-csgmc155 181 13 the the DT cord-267001-csgmc155 181 14 alum alum NN cord-267001-csgmc155 181 15 - - HYPH cord-267001-csgmc155 181 16 adjuvanted adjuvante VBN cord-267001-csgmc155 181 17 RBD RBD NNP cord-267001-csgmc155 181 18 vaccine vaccine NN cord-267001-csgmc155 181 19 were be VBD cord-267001-csgmc155 181 20 actually actually RB cord-267001-csgmc155 181 21 similar similar JJ cord-267001-csgmc155 181 22 to to IN cord-267001-csgmc155 181 23 those those DT cord-267001-csgmc155 181 24 in in IN cord-267001-csgmc155 181 25 the the DT cord-267001-csgmc155 181 26 control control NN cord-267001-csgmc155 181 27 group group NN cord-267001-csgmc155 181 28 that that WDT cord-267001-csgmc155 181 29 received receive VBD cord-267001-csgmc155 181 30 only only RB cord-267001-csgmc155 181 31 RBD RBD NNP cord-267001-csgmc155 181 32 ( ( -LRB- cord-267001-csgmc155 181 33 G4 G4 NNP cord-267001-csgmc155 181 34 vs. vs. IN cord-267001-csgmc155 181 35 G2 G2 NNP cord-267001-csgmc155 181 36 ) ) -RRB- cord-267001-csgmc155 181 37 . . . cord-267001-csgmc155 182 1 As as IN cord-267001-csgmc155 182 2 observed observe VBN cord-267001-csgmc155 182 3 with with IN cord-267001-csgmc155 182 4 the the DT cord-267001-csgmc155 182 5 number number NN cord-267001-csgmc155 182 6 of of IN cord-267001-csgmc155 182 7 activated activate VBN cord-267001-csgmc155 182 8 monocytes monocyte NNS cord-267001-csgmc155 182 9 , , , cord-267001-csgmc155 182 10 migratory migratory JJ cord-267001-csgmc155 182 11 monocytes monocyte NNS cord-267001-csgmc155 182 12 in in IN cord-267001-csgmc155 182 13 the the DT cord-267001-csgmc155 182 14 LNs ln NNS cord-267001-csgmc155 182 15 of of IN cord-267001-csgmc155 182 16 mice mouse NNS cord-267001-csgmc155 182 17 that that WDT cord-267001-csgmc155 182 18 received receive VBD cord-267001-csgmc155 182 19 rASP-1 rasp-1 CD cord-267001-csgmc155 182 20 and and CC cord-267001-csgmc155 182 21 the the DT cord-267001-csgmc155 182 22 alum alum NN cord-267001-csgmc155 182 23 - - HYPH cord-267001-csgmc155 182 24 adjuvanted adjuvante VBN cord-267001-csgmc155 182 25 RBD RBD NNP cord-267001-csgmc155 182 26 vaccine vaccine NN cord-267001-csgmc155 182 27 co co NNS cord-267001-csgmc155 182 28 - - VBN cord-267001-csgmc155 182 29 administered administer VBN cord-267001-csgmc155 182 30 in in IN cord-267001-csgmc155 182 31 separate separate JJ cord-267001-csgmc155 182 32 sites site NNS cord-267001-csgmc155 182 33 were be VBD cord-267001-csgmc155 182 34 significantly significantly RB cord-267001-csgmc155 182 35 higher high JJR cord-267001-csgmc155 182 36 in in IN cord-267001-csgmc155 182 37 mice mouse NNS cord-267001-csgmc155 182 38 than than IN cord-267001-csgmc155 182 39 in in IN cord-267001-csgmc155 182 40 mice mouse NNS cord-267001-csgmc155 182 41 received receive VBD cord-267001-csgmc155 182 42 RBD RBD NNP cord-267001-csgmc155 182 43 + + CC cord-267001-csgmc155 183 1 rASP-1 rasp-1 LS cord-267001-csgmc155 183 2 + + CC cord-267001-csgmc155 183 3 alum alum NN cord-267001-csgmc155 183 4 administered administer VBN cord-267001-csgmc155 183 5 in in IN cord-267001-csgmc155 183 6 a a DT cord-267001-csgmc155 183 7 single single JJ cord-267001-csgmc155 183 8 inoculum inoculum NN cord-267001-csgmc155 183 9 ( ( -LRB- cord-267001-csgmc155 183 10 G6 G6 NNP cord-267001-csgmc155 183 11 vs vs IN cord-267001-csgmc155 183 12 G5 G5 NNP cord-267001-csgmc155 183 13 ; ; : cord-267001-csgmc155 183 14 Figure Figure NNP cord-267001-csgmc155 183 15 3C 3c NN cord-267001-csgmc155 183 16 ) ) -RRB- cord-267001-csgmc155 183 17 . . . cord-267001-csgmc155 184 1 Nevertheless nevertheless RB cord-267001-csgmc155 184 2 , , , cord-267001-csgmc155 184 3 a a DT cord-267001-csgmc155 184 4 synergistic synergistic JJ cord-267001-csgmc155 184 5 effect effect NN cord-267001-csgmc155 184 6 was be VBD cord-267001-csgmc155 184 7 observed observe VBN cord-267001-csgmc155 184 8 when when WRB cord-267001-csgmc155 184 9 rASP-1 rASP-1 NNP cord-267001-csgmc155 184 10 was be VBD cord-267001-csgmc155 184 11 added add VBN cord-267001-csgmc155 184 12 to to IN cord-267001-csgmc155 184 13 the the DT cord-267001-csgmc155 184 14 RBD RBD NNP cord-267001-csgmc155 184 15 vaccine vaccine NN cord-267001-csgmc155 184 16 with with IN cord-267001-csgmc155 184 17 or or CC cord-267001-csgmc155 184 18 without without IN cord-267001-csgmc155 184 19 alum alum NN cord-267001-csgmc155 184 20 with with IN cord-267001-csgmc155 184 21 respect respect NN cord-267001-csgmc155 184 22 to to IN cord-267001-csgmc155 184 23 CCR7 CCR7 NNP cord-267001-csgmc155 185 1 + + CC cord-267001-csgmc155 185 2 ( ( -LRB- cord-267001-csgmc155 185 3 migratory migratory JJ cord-267001-csgmc155 185 4 ) ) -RRB- cord-267001-csgmc155 185 5 monocyte monocyte NNP cord-267001-csgmc155 185 6 subset subset NNP cord-267001-csgmc155 185 7 . . . cord-267001-csgmc155 186 1 The the DT cord-267001-csgmc155 186 2 number number NN cord-267001-csgmc155 186 3 of of IN cord-267001-csgmc155 186 4 migratory migratory JJ cord-267001-csgmc155 186 5 monocytes monocyte NNS cord-267001-csgmc155 186 6 ( ( -LRB- cord-267001-csgmc155 186 7 CD45 CD45 NNP cord-267001-csgmc155 186 8 + + CC cord-267001-csgmc155 186 9 CD11c CD11c NNP cord-267001-csgmc155 186 10 -Ly6C -Ly6C NNP cord-267001-csgmc155 186 11 + + CC cord-267001-csgmc155 186 12 CCR7 CCR7 NNP cord-267001-csgmc155 186 13 + + CC cord-267001-csgmc155 186 14 ) ) -RRB- cord-267001-csgmc155 186 15 in in IN cord-267001-csgmc155 186 16 the the DT cord-267001-csgmc155 186 17 LN LN NNP cord-267001-csgmc155 186 18 were be VBD cord-267001-csgmc155 186 19 significantly significantly RB cord-267001-csgmc155 186 20 higher high JJR cord-267001-csgmc155 186 21 in in IN cord-267001-csgmc155 186 22 mice mouse NNS cord-267001-csgmc155 186 23 where where WRB cord-267001-csgmc155 186 24 rASP-1 rasp-1 NN cord-267001-csgmc155 186 25 and and CC cord-267001-csgmc155 186 26 the the DT cord-267001-csgmc155 186 27 alum alum NN cord-267001-csgmc155 186 28 - - HYPH cord-267001-csgmc155 186 29 adjuvanted adjuvante VBN cord-267001-csgmc155 186 30 RBD RBD NNP cord-267001-csgmc155 186 31 vaccine vaccine NN cord-267001-csgmc155 186 32 were be VBD cord-267001-csgmc155 186 33 co co VBN cord-267001-csgmc155 186 34 - - VBN cord-267001-csgmc155 186 35 administered administer VBN cord-267001-csgmc155 186 36 in in IN cord-267001-csgmc155 186 37 separate separate JJ cord-267001-csgmc155 186 38 sites site NNS cord-267001-csgmc155 186 39 , , , cord-267001-csgmc155 186 40 RBD RBD NNP cord-267001-csgmc155 186 41 + + CC cord-267001-csgmc155 186 42 rASP-1 rasp-1 NN cord-267001-csgmc155 186 43 + + CC cord-267001-csgmc155 186 44 alum alum NN cord-267001-csgmc155 186 45 was be VBD cord-267001-csgmc155 186 46 administered administer VBN cord-267001-csgmc155 186 47 in in IN cord-267001-csgmc155 186 48 a a DT cord-267001-csgmc155 186 49 single single JJ cord-267001-csgmc155 186 50 inoculum inoculum NN cord-267001-csgmc155 186 51 or or CC cord-267001-csgmc155 186 52 the the DT cord-267001-csgmc155 186 53 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 186 54 RBD RBD NNP cord-267001-csgmc155 186 55 vaccine vaccine NN cord-267001-csgmc155 186 56 vs. vs. IN cord-267001-csgmc155 186 57 the the DT cord-267001-csgmc155 186 58 alum alum NN cord-267001-csgmc155 186 59 - - HYPH cord-267001-csgmc155 186 60 adjuvanted adjuvante VBN cord-267001-csgmc155 186 61 RBD RBD NNP cord-267001-csgmc155 186 62 vaccine vaccine NN cord-267001-csgmc155 186 63 ( ( -LRB- cord-267001-csgmc155 186 64 G6 G6 NNP cord-267001-csgmc155 186 65 , , , cord-267001-csgmc155 186 66 G5 G5 NNP cord-267001-csgmc155 186 67 and and CC cord-267001-csgmc155 186 68 G3 G3 NNP cord-267001-csgmc155 186 69 vs. vs. IN cord-267001-csgmc155 186 70 G4 G4 NNP cord-267001-csgmc155 186 71 ; ; : cord-267001-csgmc155 186 72 Figure Figure NNP cord-267001-csgmc155 186 73 3C 3c NN cord-267001-csgmc155 186 74 ) ) -RRB- cord-267001-csgmc155 186 75 . . . cord-267001-csgmc155 187 1 The the DT cord-267001-csgmc155 187 2 number number NN cord-267001-csgmc155 187 3 of of IN cord-267001-csgmc155 187 4 migratory migratory JJ cord-267001-csgmc155 187 5 monocytes monocyte NNS cord-267001-csgmc155 187 6 in in IN cord-267001-csgmc155 187 7 the the DT cord-267001-csgmc155 187 8 LN ln NN cord-267001-csgmc155 187 9 of of IN cord-267001-csgmc155 187 10 mice mouse NNS cord-267001-csgmc155 187 11 that that WDT cord-267001-csgmc155 187 12 received receive VBD cord-267001-csgmc155 187 13 the the DT cord-267001-csgmc155 187 14 alum alum NN cord-267001-csgmc155 187 15 - - HYPH cord-267001-csgmc155 187 16 adjuvanted adjuvante VBN cord-267001-csgmc155 187 17 RBD RBD NNP cord-267001-csgmc155 187 18 vaccine vaccine NN cord-267001-csgmc155 187 19 were be VBD cord-267001-csgmc155 187 20 actually actually RB cord-267001-csgmc155 187 21 similar similar JJ cord-267001-csgmc155 187 22 to to IN cord-267001-csgmc155 187 23 those those DT cord-267001-csgmc155 187 24 in in IN cord-267001-csgmc155 187 25 the the DT cord-267001-csgmc155 187 26 control control NN cord-267001-csgmc155 187 27 group group NN cord-267001-csgmc155 187 28 that that WDT cord-267001-csgmc155 187 29 received receive VBD cord-267001-csgmc155 187 30 only only RB cord-267001-csgmc155 187 31 RBD RBD NNP cord-267001-csgmc155 187 32 ( ( -LRB- cord-267001-csgmc155 187 33 G4 G4 NNP cord-267001-csgmc155 187 34 vs. vs. IN cord-267001-csgmc155 187 35 G2 G2 NNP cord-267001-csgmc155 187 36 ) ) -RRB- cord-267001-csgmc155 187 37 . . . cord-267001-csgmc155 188 1 As as IN cord-267001-csgmc155 188 2 observed observe VBN cord-267001-csgmc155 188 3 with with IN cord-267001-csgmc155 188 4 the the DT cord-267001-csgmc155 188 5 number number NN cord-267001-csgmc155 188 6 of of IN cord-267001-csgmc155 188 7 activated activate VBN cord-267001-csgmc155 188 8 monocytes monocyte NNS cord-267001-csgmc155 188 9 , , , cord-267001-csgmc155 188 10 migratory migratory JJ cord-267001-csgmc155 188 11 monocytes monocyte NNS cord-267001-csgmc155 188 12 in in IN cord-267001-csgmc155 188 13 the the DT cord-267001-csgmc155 188 14 LNs ln NNS cord-267001-csgmc155 188 15 of of IN cord-267001-csgmc155 188 16 mice mouse NNS cord-267001-csgmc155 188 17 that that WDT cord-267001-csgmc155 188 18 received receive VBD cord-267001-csgmc155 188 19 rASP-1 rasp-1 CD cord-267001-csgmc155 188 20 and and CC cord-267001-csgmc155 188 21 the the DT cord-267001-csgmc155 188 22 alum alum NN cord-267001-csgmc155 188 23 - - HYPH cord-267001-csgmc155 188 24 adjuvanted adjuvante VBN cord-267001-csgmc155 188 25 RBD RBD NNP cord-267001-csgmc155 188 26 vaccine vaccine NN cord-267001-csgmc155 188 27 co co NNS cord-267001-csgmc155 188 28 - - VBN cord-267001-csgmc155 188 29 administered administer VBN cord-267001-csgmc155 188 30 in in IN cord-267001-csgmc155 188 31 separate separate JJ cord-267001-csgmc155 188 32 sites site NNS cord-267001-csgmc155 188 33 were be VBD cord-267001-csgmc155 188 34 significantly significantly RB cord-267001-csgmc155 188 35 higher high JJR cord-267001-csgmc155 188 36 in in IN cord-267001-csgmc155 188 37 mice mouse NNS cord-267001-csgmc155 188 38 than than IN cord-267001-csgmc155 188 39 in in IN cord-267001-csgmc155 188 40 mice mouse NNS cord-267001-csgmc155 188 41 received receive VBD cord-267001-csgmc155 188 42 RBD RBD NNP cord-267001-csgmc155 188 43 + + CC cord-267001-csgmc155 189 1 rASP-1 rasp-1 LS cord-267001-csgmc155 189 2 + + CC cord-267001-csgmc155 189 3 alum alum NN cord-267001-csgmc155 189 4 administered administer VBN cord-267001-csgmc155 189 5 in in IN cord-267001-csgmc155 189 6 a a DT cord-267001-csgmc155 189 7 single single JJ cord-267001-csgmc155 189 8 inoculum inoculum NN cord-267001-csgmc155 189 9 ( ( -LRB- cord-267001-csgmc155 189 10 G6 G6 NNP cord-267001-csgmc155 189 11 vs vs IN cord-267001-csgmc155 189 12 G5 G5 NNP cord-267001-csgmc155 189 13 ; ; : cord-267001-csgmc155 189 14 Figure Figure NNP cord-267001-csgmc155 189 15 3C 3c NN cord-267001-csgmc155 189 16 ) ) -RRB- cord-267001-csgmc155 189 17 . . . cord-267001-csgmc155 190 1 To to TO cord-267001-csgmc155 190 2 investigate investigate VB cord-267001-csgmc155 190 3 the the DT cord-267001-csgmc155 190 4 possible possible JJ cord-267001-csgmc155 190 5 contribution contribution NN cord-267001-csgmc155 190 6 of of IN cord-267001-csgmc155 190 7 TfH tfh NN cord-267001-csgmc155 190 8 and and CC cord-267001-csgmc155 190 9 GC GC NNP cord-267001-csgmc155 190 10 B B NNP cord-267001-csgmc155 190 11 cells cell NNS cord-267001-csgmc155 190 12 to to IN cord-267001-csgmc155 190 13 the the DT cord-267001-csgmc155 190 14 robust robust JJ cord-267001-csgmc155 190 15 functional functional JJ cord-267001-csgmc155 190 16 antibody antibody NN cord-267001-csgmc155 190 17 responses response NNS cord-267001-csgmc155 190 18 induced induce VBN cord-267001-csgmc155 190 19 in in IN cord-267001-csgmc155 190 20 mice mouse NNS cord-267001-csgmc155 190 21 administered administer VBN cord-267001-csgmc155 190 22 with with IN cord-267001-csgmc155 190 23 rASP-1 rasp-1 CD cord-267001-csgmc155 190 24 and and CC cord-267001-csgmc155 190 25 the the DT cord-267001-csgmc155 190 26 alum alum NN cord-267001-csgmc155 190 27 - - HYPH cord-267001-csgmc155 190 28 adjuvanted adjuvante VBN cord-267001-csgmc155 190 29 RBD RBD NNP cord-267001-csgmc155 190 30 vaccine vaccine NN cord-267001-csgmc155 190 31 in in IN cord-267001-csgmc155 190 32 separate separate JJ cord-267001-csgmc155 190 33 injection injection NN cord-267001-csgmc155 190 34 sites site NNS cord-267001-csgmc155 190 35 , , , cord-267001-csgmc155 190 36 LN LN NNP cord-267001-csgmc155 190 37 from from IN cord-267001-csgmc155 190 38 7 7 CD cord-267001-csgmc155 190 39 days day NNS cord-267001-csgmc155 190 40 post-2nd post-2nd JJ cord-267001-csgmc155 190 41 immunization immunization NN cord-267001-csgmc155 190 42 were be VBD cord-267001-csgmc155 190 43 analyzed analyze VBN cord-267001-csgmc155 190 44 for for IN cord-267001-csgmc155 190 45 the the DT cord-267001-csgmc155 190 46 TfH tfh NN cord-267001-csgmc155 190 47 ( ( -LRB- cord-267001-csgmc155 190 48 Figure figure NN cord-267001-csgmc155 190 49 4A 4a CD cord-267001-csgmc155 190 50 ) ) -RRB- cord-267001-csgmc155 190 51 and and CC cord-267001-csgmc155 190 52 GC GC NNP cord-267001-csgmc155 190 53 B B NNP cord-267001-csgmc155 191 1 ( ( -LRB- cord-267001-csgmc155 191 2 Figure figure NN cord-267001-csgmc155 191 3 5A 5a CD cord-267001-csgmc155 191 4 ) ) -RRB- cord-267001-csgmc155 191 5 cell cell NN cord-267001-csgmc155 191 6 frequencies frequency NNS cord-267001-csgmc155 191 7 . . . cord-267001-csgmc155 192 1 Although although IN cord-267001-csgmc155 192 2 the the DT cord-267001-csgmc155 192 3 frequency frequency NN cord-267001-csgmc155 192 4 of of IN cord-267001-csgmc155 192 5 total total JJ cord-267001-csgmc155 192 6 CD4 CD4 NNP cord-267001-csgmc155 192 7 + + CC cord-267001-csgmc155 192 8 T t NN cord-267001-csgmc155 192 9 cells cell NNS cord-267001-csgmc155 192 10 within within IN cord-267001-csgmc155 192 11 the the DT cord-267001-csgmc155 192 12 LN ln NN cord-267001-csgmc155 192 13 was be VBD cord-267001-csgmc155 192 14 not not RB cord-267001-csgmc155 192 15 significantly significantly RB cord-267001-csgmc155 192 16 different different JJ cord-267001-csgmc155 192 17 between between IN cord-267001-csgmc155 192 18 the the DT cord-267001-csgmc155 192 19 various various JJ cord-267001-csgmc155 192 20 immunization immunization NN cord-267001-csgmc155 192 21 groups group NNS cord-267001-csgmc155 192 22 ( ( -LRB- cord-267001-csgmc155 192 23 Figure figure NN cord-267001-csgmc155 192 24 S4B s4b CD cord-267001-csgmc155 192 25 ) ) -RRB- cord-267001-csgmc155 192 26 , , , cord-267001-csgmc155 192 27 the the DT cord-267001-csgmc155 192 28 frequency frequency NN cord-267001-csgmc155 192 29 of of IN cord-267001-csgmc155 192 30 the the DT cord-267001-csgmc155 192 31 TfH tfh NN cord-267001-csgmc155 192 32 ( ( -LRB- cord-267001-csgmc155 192 33 CD4 CD4 NNP cord-267001-csgmc155 192 34 + + CC cord-267001-csgmc155 192 35 CXCR5 cxcr5 XX cord-267001-csgmc155 193 1 + + CC cord-267001-csgmc155 194 1 PD-1 PD-1 NNP cord-267001-csgmc155 194 2 + + CC cord-267001-csgmc155 195 1 ) ) -RRB- cord-267001-csgmc155 195 2 cells cell NNS cord-267001-csgmc155 195 3 within within IN cord-267001-csgmc155 195 4 the the DT cord-267001-csgmc155 195 5 LN ln NN cord-267001-csgmc155 195 6 of of IN cord-267001-csgmc155 195 7 mice mouse NNS cord-267001-csgmc155 195 8 administered administer VBN cord-267001-csgmc155 195 9 with with IN cord-267001-csgmc155 195 10 rASP-1 rasp-1 CD cord-267001-csgmc155 195 11 and and CC cord-267001-csgmc155 195 12 the the DT cord-267001-csgmc155 195 13 alum alum NN cord-267001-csgmc155 195 14 - - HYPH cord-267001-csgmc155 195 15 adjuvanted adjuvante VBN cord-267001-csgmc155 195 16 RBD RBD NNP cord-267001-csgmc155 195 17 vaccine vaccine NN cord-267001-csgmc155 195 18 in in IN cord-267001-csgmc155 195 19 separate separate JJ cord-267001-csgmc155 195 20 sites site NNS cord-267001-csgmc155 195 21 ( ( -LRB- cord-267001-csgmc155 195 22 G6 G6 NNP cord-267001-csgmc155 195 23 ) ) -RRB- cord-267001-csgmc155 195 24 was be VBD cord-267001-csgmc155 195 25 2.3-fold 2.3-fold CD cord-267001-csgmc155 195 26 higher high JJR cord-267001-csgmc155 195 27 than than IN cord-267001-csgmc155 195 28 in in IN cord-267001-csgmc155 195 29 mice mouse NNS cord-267001-csgmc155 195 30 administered administer VBN cord-267001-csgmc155 195 31 with with IN cord-267001-csgmc155 195 32 the the DT cord-267001-csgmc155 195 33 RBD RBD NNP cord-267001-csgmc155 195 34 + + CC cord-267001-csgmc155 195 35 rASP-1 rasp-1 NN cord-267001-csgmc155 196 1 + + CC cord-267001-csgmc155 197 1 alum alum NN cord-267001-csgmc155 197 2 vaccine vaccine NN cord-267001-csgmc155 197 3 in in IN cord-267001-csgmc155 197 4 a a DT cord-267001-csgmc155 197 5 single single JJ cord-267001-csgmc155 197 6 inoculum inoculum NN cord-267001-csgmc155 197 7 , , , cord-267001-csgmc155 197 8 and and CC cord-267001-csgmc155 198 1 5.5-and 5.5-and CD cord-267001-csgmc155 198 2 2.1-fold 2.1-fold CD cord-267001-csgmc155 198 3 higher high JJR cord-267001-csgmc155 198 4 versus versus IN cord-267001-csgmc155 198 5 rASP-1-and rasp-1-and JJ cord-267001-csgmc155 198 6 alum alum NN cord-267001-csgmc155 198 7 - - HYPH cord-267001-csgmc155 198 8 adjuvanted adjuvante VBN cord-267001-csgmc155 198 9 RBD RBD NNP cord-267001-csgmc155 198 10 vaccines vaccine NNS cord-267001-csgmc155 198 11 ( ( -LRB- cord-267001-csgmc155 198 12 G6 G6 NNP cord-267001-csgmc155 198 13 vs. vs. IN cord-267001-csgmc155 198 14 G3 G3 NNP cord-267001-csgmc155 198 15 and and CC cord-267001-csgmc155 198 16 G4 G4 NNP cord-267001-csgmc155 198 17 , , , cord-267001-csgmc155 198 18 respectively respectively RB cord-267001-csgmc155 198 19 ; ; : cord-267001-csgmc155 198 20 Figure figure NN cord-267001-csgmc155 198 21 4B 4b CD cord-267001-csgmc155 198 22 ) ) -RRB- cord-267001-csgmc155 198 23 . . . cord-267001-csgmc155 199 1 Importantly importantly RB cord-267001-csgmc155 199 2 , , , cord-267001-csgmc155 199 3 the the DT cord-267001-csgmc155 199 4 fold fold JJ cord-267001-csgmc155 199 5 increase increase NN cord-267001-csgmc155 199 6 in in IN cord-267001-csgmc155 199 7 the the DT cord-267001-csgmc155 199 8 TfH tfh NN cord-267001-csgmc155 199 9 cells cell NNS cord-267001-csgmc155 199 10 was be VBD cord-267001-csgmc155 199 11 positively positively RB cord-267001-csgmc155 199 12 and and CC cord-267001-csgmc155 199 13 significantly significantly RB cord-267001-csgmc155 199 14 associated associate VBN cord-267001-csgmc155 199 15 with with IN cord-267001-csgmc155 199 16 the the DT cord-267001-csgmc155 199 17 neutralizing neutralize VBG cord-267001-csgmc155 199 18 antibody antibody NN cord-267001-csgmc155 199 19 titers titer NNS cord-267001-csgmc155 199 20 against against IN cord-267001-csgmc155 199 21 the the DT cord-267001-csgmc155 199 22 pseudotyped pseudotyped NNP cord-267001-csgmc155 199 23 MERS MERS NNP cord-267001-csgmc155 199 24 - - HYPH cord-267001-csgmc155 199 25 CoV CoV NNP cord-267001-csgmc155 199 26 in in IN cord-267001-csgmc155 199 27 two two CD cord-267001-csgmc155 199 28 immunization immunization NN cord-267001-csgmc155 199 29 groups group NNS cord-267001-csgmc155 199 30 , , , cord-267001-csgmc155 199 31 namely namely RB cord-267001-csgmc155 199 32 mice mouse NNS cord-267001-csgmc155 199 33 that that WDT cord-267001-csgmc155 199 34 were be VBD cord-267001-csgmc155 199 35 immunized immunize VBN cord-267001-csgmc155 199 36 with with IN cord-267001-csgmc155 199 37 rASP-1 rASP-1 NNP cord-267001-csgmc155 199 38 and and CC cord-267001-csgmc155 199 39 the the DT cord-267001-csgmc155 199 40 alum alum NN cord-267001-csgmc155 199 41 - - HYPH cord-267001-csgmc155 199 42 adjuvanted adjuvante VBN cord-267001-csgmc155 199 43 RBD RBD NNP cord-267001-csgmc155 199 44 vaccine vaccine NN cord-267001-csgmc155 199 45 in in IN cord-267001-csgmc155 199 46 separate separate JJ cord-267001-csgmc155 199 47 sites site NNS cord-267001-csgmc155 199 48 ( ( -LRB- cord-267001-csgmc155 199 49 G6 G6 NNP cord-267001-csgmc155 199 50 ; ; : cord-267001-csgmc155 199 51 r r NN cord-267001-csgmc155 199 52 = = SYM cord-267001-csgmc155 199 53 0.535 0.535 CD cord-267001-csgmc155 199 54 , , , cord-267001-csgmc155 199 55 p p NN cord-267001-csgmc155 199 56 = = SYM cord-267001-csgmc155 199 57 0.0150 0.0150 CD cord-267001-csgmc155 199 58 ) ) -RRB- cord-267001-csgmc155 199 59 and and CC cord-267001-csgmc155 199 60 mice mouse NNS cord-267001-csgmc155 199 61 immunized immunize VBN cord-267001-csgmc155 199 62 with with IN cord-267001-csgmc155 199 63 RBD RBD NNP cord-267001-csgmc155 199 64 + + CC cord-267001-csgmc155 200 1 rASP-1 rasp-1 LS cord-267001-csgmc155 200 2 + + CC cord-267001-csgmc155 200 3 alum alum NN cord-267001-csgmc155 200 4 vaccine vaccine NN cord-267001-csgmc155 200 5 in in IN cord-267001-csgmc155 200 6 a a DT cord-267001-csgmc155 200 7 single single JJ cord-267001-csgmc155 200 8 inoculum inoculum NN cord-267001-csgmc155 200 9 ( ( -LRB- cord-267001-csgmc155 200 10 G5 G5 NNP cord-267001-csgmc155 200 11 ; ; : cord-267001-csgmc155 200 12 r r NN cord-267001-csgmc155 200 13 = = SYM cord-267001-csgmc155 200 14 0.593 0.593 CD cord-267001-csgmc155 200 15 , , , cord-267001-csgmc155 200 16 p p NN cord-267001-csgmc155 200 17 = = SYM cord-267001-csgmc155 200 18 0.0058 0.0058 CD cord-267001-csgmc155 200 19 ) ) -RRB- cord-267001-csgmc155 201 1 ( ( -LRB- cord-267001-csgmc155 201 2 Figure figure NN cord-267001-csgmc155 201 3 4C 4c CD cord-267001-csgmc155 201 4 ) ) -RRB- cord-267001-csgmc155 201 5 . . . cord-267001-csgmc155 202 1 Notably notably RB cord-267001-csgmc155 202 2 , , , cord-267001-csgmc155 202 3 the the DT cord-267001-csgmc155 202 4 frequency frequency NN cord-267001-csgmc155 202 5 of of IN cord-267001-csgmc155 202 6 B b NN cord-267001-csgmc155 202 7 cells cell NNS cord-267001-csgmc155 202 8 ( ( -LRB- cord-267001-csgmc155 202 9 B220 b220 RB cord-267001-csgmc155 202 10 + + JJ cord-267001-csgmc155 202 11 ) ) -RRB- cord-267001-csgmc155 202 12 in in IN cord-267001-csgmc155 202 13 the the DT cord-267001-csgmc155 202 14 LN ln NN cord-267001-csgmc155 202 15 was be VBD cord-267001-csgmc155 202 16 also also RB cord-267001-csgmc155 202 17 significantly significantly RB cord-267001-csgmc155 202 18 higher high JJR cord-267001-csgmc155 202 19 in in IN cord-267001-csgmc155 202 20 mice mouse NNS cord-267001-csgmc155 202 21 administered administer VBN cord-267001-csgmc155 202 22 with with IN cord-267001-csgmc155 202 23 rASP-1 rasp-1 CD cord-267001-csgmc155 202 24 and and CC cord-267001-csgmc155 202 25 the the DT cord-267001-csgmc155 202 26 alum alum NN cord-267001-csgmc155 202 27 - - HYPH cord-267001-csgmc155 202 28 adjuvanted adjuvante VBN cord-267001-csgmc155 202 29 RBD RBD NNP cord-267001-csgmc155 202 30 vaccine vaccine NN cord-267001-csgmc155 202 31 in in IN cord-267001-csgmc155 202 32 separate separate JJ cord-267001-csgmc155 202 33 sites site NNS cord-267001-csgmc155 202 34 than than IN cord-267001-csgmc155 202 35 in in IN cord-267001-csgmc155 202 36 mice mouse NNS cord-267001-csgmc155 202 37 administered administer VBN cord-267001-csgmc155 202 38 with with IN cord-267001-csgmc155 202 39 RBD RBD NNP cord-267001-csgmc155 202 40 + + CC cord-267001-csgmc155 202 41 rASP-1 rasp-1 NN cord-267001-csgmc155 203 1 + + CC cord-267001-csgmc155 203 2 alum alum NN cord-267001-csgmc155 203 3 in in IN cord-267001-csgmc155 203 4 a a DT cord-267001-csgmc155 203 5 single single JJ cord-267001-csgmc155 203 6 inoculum inoculum NN cord-267001-csgmc155 203 7 , , , cord-267001-csgmc155 203 8 or or CC cord-267001-csgmc155 203 9 with with IN cord-267001-csgmc155 203 10 the the DT cord-267001-csgmc155 203 11 alum alum NN cord-267001-csgmc155 203 12 - - HYPH cord-267001-csgmc155 203 13 adjuvanted adjuvante VBN cord-267001-csgmc155 203 14 RBD RBD NNP cord-267001-csgmc155 203 15 vaccine vaccine NN cord-267001-csgmc155 203 16 or or CC cord-267001-csgmc155 203 17 with with IN cord-267001-csgmc155 203 18 the the DT cord-267001-csgmc155 203 19 RBD RBD NNP cord-267001-csgmc155 203 20 vaccine vaccine NN cord-267001-csgmc155 203 21 alone alone RB cord-267001-csgmc155 204 1 ( ( -LRB- cord-267001-csgmc155 204 2 G6 G6 NNP cord-267001-csgmc155 204 3 - - HYPH cord-267001-csgmc155 204 4 33 33 CD cord-267001-csgmc155 204 5 % % NN cord-267001-csgmc155 204 6 vs. vs. IN cord-267001-csgmc155 204 7 G5 G5 NNP cord-267001-csgmc155 204 8 - - HYPH cord-267001-csgmc155 204 9 25 25 CD cord-267001-csgmc155 204 10 % % NN cord-267001-csgmc155 204 11 , , , cord-267001-csgmc155 204 12 G4 G4 NNP cord-267001-csgmc155 204 13 - - HYPH cord-267001-csgmc155 204 14 25 25 CD cord-267001-csgmc155 204 15 % % NN cord-267001-csgmc155 204 16 , , , cord-267001-csgmc155 204 17 and and CC cord-267001-csgmc155 204 18 G2 G2 NNP cord-267001-csgmc155 204 19 - - HYPH cord-267001-csgmc155 204 20 24 24 CD cord-267001-csgmc155 204 21 % % NN cord-267001-csgmc155 204 22 respectively respectively RB cord-267001-csgmc155 204 23 ; ; : cord-267001-csgmc155 204 24 Figure figure NN cord-267001-csgmc155 204 25 5B 5b NN cord-267001-csgmc155 204 26 ) ) -RRB- cord-267001-csgmc155 204 27 . . . cord-267001-csgmc155 205 1 Additionally additionally RB cord-267001-csgmc155 205 2 , , , cord-267001-csgmc155 205 3 the the DT cord-267001-csgmc155 205 4 frequency frequency NN cord-267001-csgmc155 205 5 of of IN cord-267001-csgmc155 205 6 B b NN cord-267001-csgmc155 205 7 cells cell NNS cord-267001-csgmc155 205 8 in in IN cord-267001-csgmc155 205 9 mice mouse NNS cord-267001-csgmc155 205 10 immunized immunize VBN cord-267001-csgmc155 205 11 with with IN cord-267001-csgmc155 205 12 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 206 1 RBD RBD NNP cord-267001-csgmc155 206 2 was be VBD cord-267001-csgmc155 206 3 also also RB cord-267001-csgmc155 206 4 significantly significantly RB cord-267001-csgmc155 206 5 higher high JJR cord-267001-csgmc155 206 6 as as IN cord-267001-csgmc155 206 7 compared compare VBN cord-267001-csgmc155 206 8 to to IN cord-267001-csgmc155 206 9 mice mouse NNS cord-267001-csgmc155 206 10 immunized immunize VBN cord-267001-csgmc155 206 11 with with IN cord-267001-csgmc155 206 12 RBD RBD NNP cord-267001-csgmc155 206 13 + + CC cord-267001-csgmc155 207 1 rASP-1 rasp-1 LS cord-267001-csgmc155 207 2 + + CC cord-267001-csgmc155 207 3 alum alum NN cord-267001-csgmc155 207 4 in in IN cord-267001-csgmc155 207 5 a a DT cord-267001-csgmc155 207 6 single single JJ cord-267001-csgmc155 207 7 inoculum inoculum NN cord-267001-csgmc155 207 8 ( ( -LRB- cord-267001-csgmc155 207 9 G3 G3 NNP cord-267001-csgmc155 207 10 - - HYPH cord-267001-csgmc155 207 11 29 29 CD cord-267001-csgmc155 207 12 % % NN cord-267001-csgmc155 207 13 vs. vs. IN cord-267001-csgmc155 207 14 G5 G5 NNP cord-267001-csgmc155 207 15 - - HYPH cord-267001-csgmc155 207 16 25 25 CD cord-267001-csgmc155 207 17 % % NN cord-267001-csgmc155 207 18 respectively respectively RB cord-267001-csgmc155 207 19 ; ; : cord-267001-csgmc155 207 20 Figure figure NN cord-267001-csgmc155 207 21 5B 5b NN cord-267001-csgmc155 207 22 ) ) -RRB- cord-267001-csgmc155 207 23 . . . cord-267001-csgmc155 208 1 Formulating formulate VBG cord-267001-csgmc155 208 2 the the DT cord-267001-csgmc155 208 3 vaccine vaccine NN cord-267001-csgmc155 208 4 with with IN cord-267001-csgmc155 208 5 rASP-1 rASP-1 NNP cord-267001-csgmc155 208 6 in in IN cord-267001-csgmc155 208 7 an an DT cord-267001-csgmc155 208 8 aqueous aqueous JJ cord-267001-csgmc155 208 9 formulation formulation NN cord-267001-csgmc155 208 10 ( ( -LRB- cord-267001-csgmc155 208 11 not not RB cord-267001-csgmc155 208 12 adsorbed adsorb VBN cord-267001-csgmc155 208 13 to to IN cord-267001-csgmc155 208 14 alum alum NN cord-267001-csgmc155 208 15 ) ) -RRB- cord-267001-csgmc155 208 16 might may MD cord-267001-csgmc155 208 17 have have VB cord-267001-csgmc155 208 18 been be VBN cord-267001-csgmc155 208 19 critical critical JJ cord-267001-csgmc155 208 20 for for IN cord-267001-csgmc155 208 21 the the DT cord-267001-csgmc155 208 22 increased increase VBN cord-267001-csgmc155 208 23 number number NN cord-267001-csgmc155 208 24 of of IN cord-267001-csgmc155 208 25 B b NN cord-267001-csgmc155 208 26 cells cell NNS cord-267001-csgmc155 208 27 in in IN cord-267001-csgmc155 208 28 these these DT cord-267001-csgmc155 208 29 two two CD cord-267001-csgmc155 208 30 vaccine vaccine NN cord-267001-csgmc155 208 31 formulations formulation NNS cord-267001-csgmc155 208 32 ( ( -LRB- cord-267001-csgmc155 208 33 G6 G6 NNP cord-267001-csgmc155 208 34 and and CC cord-267001-csgmc155 208 35 G3 G3 NNP cord-267001-csgmc155 208 36 ) ) -RRB- cord-267001-csgmc155 208 37 . . . cord-267001-csgmc155 209 1 When when WRB cord-267001-csgmc155 209 2 the the DT cord-267001-csgmc155 209 3 frequency frequency NN cord-267001-csgmc155 209 4 of of IN cord-267001-csgmc155 209 5 GC GC NNP cord-267001-csgmc155 209 6 B B NNP cord-267001-csgmc155 209 7 cells cell NNS cord-267001-csgmc155 209 8 ( ( -LRB- cord-267001-csgmc155 209 9 B220 b220 RB cord-267001-csgmc155 209 10 + + SYM cord-267001-csgmc155 209 11 CD95 CD95 NNP cord-267001-csgmc155 209 12 + + CC cord-267001-csgmc155 209 13 GL-7 GL-7 NNP cord-267001-csgmc155 209 14 + + CC cord-267001-csgmc155 209 15 ) ) -RRB- cord-267001-csgmc155 210 1 in in IN cord-267001-csgmc155 210 2 the the DT cord-267001-csgmc155 210 3 draining drain VBG cord-267001-csgmc155 210 4 LN ln NN cord-267001-csgmc155 210 5 ( ( -LRB- cord-267001-csgmc155 210 6 Figure figure NN cord-267001-csgmc155 210 7 5C 5c CD cord-267001-csgmc155 210 8 ) ) -RRB- cord-267001-csgmc155 210 9 were be VBD cord-267001-csgmc155 210 10 analyzed analyze VBN cord-267001-csgmc155 210 11 , , , cord-267001-csgmc155 210 12 it -PRON- PRP cord-267001-csgmc155 210 13 appeared appear VBD cord-267001-csgmc155 210 14 that that IN cord-267001-csgmc155 210 15 immunization immunization NN cord-267001-csgmc155 210 16 of of IN cord-267001-csgmc155 210 17 mice mouse NNS cord-267001-csgmc155 210 18 with with IN cord-267001-csgmc155 210 19 rASP-1 rasp-1 CD cord-267001-csgmc155 210 20 and and CC cord-267001-csgmc155 210 21 the the DT cord-267001-csgmc155 210 22 alum alum NN cord-267001-csgmc155 210 23 - - HYPH cord-267001-csgmc155 210 24 adjuvanted adjuvante VBN cord-267001-csgmc155 210 25 RBD RBD NNP cord-267001-csgmc155 210 26 vaccine vaccine NN cord-267001-csgmc155 210 27 in in IN cord-267001-csgmc155 210 28 separate separate JJ cord-267001-csgmc155 210 29 sites site NNS cord-267001-csgmc155 210 30 ( ( -LRB- cord-267001-csgmc155 210 31 G6 G6 NNP cord-267001-csgmc155 210 32 ) ) -RRB- cord-267001-csgmc155 210 33 induced~2-fold induced~2-fold NNP cord-267001-csgmc155 210 34 increase increase NN cord-267001-csgmc155 210 35 in in IN cord-267001-csgmc155 210 36 the the DT cord-267001-csgmc155 210 37 frequency frequency NN cord-267001-csgmc155 210 38 of of IN cord-267001-csgmc155 210 39 the the DT cord-267001-csgmc155 210 40 GC GC NNP cord-267001-csgmc155 210 41 B B NNP cord-267001-csgmc155 210 42 cells cell NNS cord-267001-csgmc155 210 43 versus versus IN cord-267001-csgmc155 210 44 immunization immunization NN cord-267001-csgmc155 210 45 with with IN cord-267001-csgmc155 210 46 RBD RBD NNP cord-267001-csgmc155 210 47 + + CC cord-267001-csgmc155 211 1 rASP-1 rasp-1 LS cord-267001-csgmc155 211 2 + + CC cord-267001-csgmc155 211 3 alum alum NN cord-267001-csgmc155 211 4 in in IN cord-267001-csgmc155 211 5 a a DT cord-267001-csgmc155 211 6 single single JJ cord-267001-csgmc155 211 7 inoculum inoculum NN cord-267001-csgmc155 211 8 and and CC cord-267001-csgmc155 211 9 the the DT cord-267001-csgmc155 211 10 alum alum NN cord-267001-csgmc155 211 11 - - HYPH cord-267001-csgmc155 211 12 adjuvanted adjuvante VBN cord-267001-csgmc155 211 13 RBD RBD NNP cord-267001-csgmc155 211 14 vaccine vaccine NN cord-267001-csgmc155 211 15 ( ( -LRB- cord-267001-csgmc155 211 16 G5 G5 NNP cord-267001-csgmc155 211 17 and and CC cord-267001-csgmc155 211 18 G4 G4 NNP cord-267001-csgmc155 211 19 ) ) -RRB- cord-267001-csgmc155 211 20 , , . cord-267001-csgmc155 212 1 and~4-fold and~4-fold . cord-267001-csgmc155 213 1 increase increase NN cord-267001-csgmc155 213 2 in in IN cord-267001-csgmc155 213 3 GC GC NNP cord-267001-csgmc155 213 4 B B NNP cord-267001-csgmc155 213 5 cells cell NNS cord-267001-csgmc155 213 6 was be VBD cord-267001-csgmc155 213 7 induced induce VBN cord-267001-csgmc155 213 8 versus versus IN cord-267001-csgmc155 213 9 immunization immunization NN cord-267001-csgmc155 213 10 with with IN cord-267001-csgmc155 213 11 the the DT cord-267001-csgmc155 213 12 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 213 13 RBD RBD NNP cord-267001-csgmc155 213 14 vaccine vaccine NN cord-267001-csgmc155 213 15 ( ( -LRB- cord-267001-csgmc155 213 16 G3 G3 NNP cord-267001-csgmc155 213 17 ; ; : cord-267001-csgmc155 213 18 Figure figure NN cord-267001-csgmc155 213 19 5C 5c CD cord-267001-csgmc155 213 20 ) ) -RRB- cord-267001-csgmc155 213 21 . . . cord-267001-csgmc155 214 1 Interestingly interestingly RB cord-267001-csgmc155 214 2 , , , cord-267001-csgmc155 214 3 the the DT cord-267001-csgmc155 214 4 alum alum NN cord-267001-csgmc155 214 5 - - HYPH cord-267001-csgmc155 214 6 adjuvanted adjuvante VBN cord-267001-csgmc155 214 7 vaccines vaccine NNS cord-267001-csgmc155 214 8 ( ( -LRB- cord-267001-csgmc155 214 9 G5 G5 NNP cord-267001-csgmc155 214 10 and and CC cord-267001-csgmc155 214 11 G4 G4 NNP cord-267001-csgmc155 214 12 ) ) -RRB- cord-267001-csgmc155 214 13 had have VBD cord-267001-csgmc155 214 14 > > XX cord-267001-csgmc155 214 15 2-fold 2-fold CD cord-267001-csgmc155 214 16 increase increase NN cord-267001-csgmc155 214 17 in in IN cord-267001-csgmc155 214 18 GC GC NNP cord-267001-csgmc155 214 19 B B NNP cord-267001-csgmc155 214 20 cells cell NNS cord-267001-csgmc155 214 21 in in IN cord-267001-csgmc155 214 22 the the DT cord-267001-csgmc155 214 23 LN ln NN cord-267001-csgmc155 214 24 compared compare VBN cord-267001-csgmc155 214 25 to to IN cord-267001-csgmc155 214 26 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 214 27 RBD RBD NNP cord-267001-csgmc155 214 28 vaccine vaccine NN cord-267001-csgmc155 214 29 ( ( -LRB- cord-267001-csgmc155 214 30 G3 G3 NNP cord-267001-csgmc155 214 31 ; ; : cord-267001-csgmc155 214 32 Figure figure NN cord-267001-csgmc155 214 33 5C 5c CD cord-267001-csgmc155 214 34 ) ) -RRB- cord-267001-csgmc155 214 35 . . . cord-267001-csgmc155 215 1 Importantly importantly RB cord-267001-csgmc155 215 2 , , , cord-267001-csgmc155 215 3 only only RB cord-267001-csgmc155 215 4 when when WRB cord-267001-csgmc155 215 5 rASP-1 rASP-1 JJS cord-267001-csgmc155 215 6 and and CC cord-267001-csgmc155 215 7 the the DT cord-267001-csgmc155 215 8 alum alum NN cord-267001-csgmc155 215 9 - - HYPH cord-267001-csgmc155 215 10 adjuvanted adjuvante VBN cord-267001-csgmc155 215 11 RBD RBD NNP cord-267001-csgmc155 215 12 vaccine vaccine NN cord-267001-csgmc155 215 13 were be VBD cord-267001-csgmc155 215 14 co co VBN cord-267001-csgmc155 215 15 - - VBN cord-267001-csgmc155 215 16 administered administer VBN cord-267001-csgmc155 215 17 in in IN cord-267001-csgmc155 215 18 separate separate JJ cord-267001-csgmc155 215 19 sites site NNS cord-267001-csgmc155 215 20 ( ( -LRB- cord-267001-csgmc155 215 21 G6 G6 NNP cord-267001-csgmc155 215 22 ) ) -RRB- cord-267001-csgmc155 215 23 was be VBD cord-267001-csgmc155 215 24 the the DT cord-267001-csgmc155 215 25 fold fold JJ cord-267001-csgmc155 215 26 increase increase NN cord-267001-csgmc155 215 27 in in IN cord-267001-csgmc155 215 28 the the DT cord-267001-csgmc155 215 29 GC GC NNP cord-267001-csgmc155 215 30 B B NNP cord-267001-csgmc155 215 31 cells cell NNS cord-267001-csgmc155 215 32 positively positively RB cord-267001-csgmc155 215 33 and and CC cord-267001-csgmc155 215 34 significantly significantly RB cord-267001-csgmc155 215 35 associated associate VBN cord-267001-csgmc155 215 36 with with IN cord-267001-csgmc155 215 37 the the DT cord-267001-csgmc155 215 38 neutralizing neutralize VBG cord-267001-csgmc155 215 39 antibody antibody NN cord-267001-csgmc155 215 40 titers titer NNS cord-267001-csgmc155 215 41 against against IN cord-267001-csgmc155 215 42 the the DT cord-267001-csgmc155 215 43 pseudotyped pseudotyped NNP cord-267001-csgmc155 215 44 MERS MERS NNP cord-267001-csgmc155 215 45 - - HYPH cord-267001-csgmc155 215 46 CoV CoV NNP cord-267001-csgmc155 216 1 ( ( -LRB- cord-267001-csgmc155 216 2 r r NN cord-267001-csgmc155 216 3 = = SYM cord-267001-csgmc155 216 4 0.550 0.550 CD cord-267001-csgmc155 216 5 , , , cord-267001-csgmc155 216 6 p p NN cord-267001-csgmc155 216 7 = = SYM cord-267001-csgmc155 216 8 0.029 0.029 CD cord-267001-csgmc155 216 9 ) ) -RRB- cord-267001-csgmc155 216 10 . . . cord-267001-csgmc155 217 1 No no DT cord-267001-csgmc155 217 2 significant significant JJ cord-267001-csgmc155 217 3 association association NN cord-267001-csgmc155 217 4 was be VBD cord-267001-csgmc155 217 5 observed observe VBN cord-267001-csgmc155 217 6 in in IN cord-267001-csgmc155 217 7 mice mouse NNS cord-267001-csgmc155 217 8 when when WRB cord-267001-csgmc155 217 9 the the DT cord-267001-csgmc155 217 10 RBD RBD NNP cord-267001-csgmc155 217 11 + + CC cord-267001-csgmc155 217 12 rASP-1 rasp-1 CD cord-267001-csgmc155 217 13 + + CC cord-267001-csgmc155 217 14 alum alum NN cord-267001-csgmc155 217 15 vaccine vaccine NN cord-267001-csgmc155 217 16 was be VBD cord-267001-csgmc155 217 17 administered administer VBN cord-267001-csgmc155 217 18 ( ( -LRB- cord-267001-csgmc155 217 19 G5 G5 NNP cord-267001-csgmc155 217 20 ) ) -RRB- cord-267001-csgmc155 217 21 as as IN cord-267001-csgmc155 217 22 a a DT cord-267001-csgmc155 217 23 single single JJ cord-267001-csgmc155 217 24 inoculum inoculum NN cord-267001-csgmc155 217 25 ( ( -LRB- cord-267001-csgmc155 217 26 r r NN cord-267001-csgmc155 217 27 = = NN cord-267001-csgmc155 217 28 −0.051 −0.051 NN cord-267001-csgmc155 217 29 , , , cord-267001-csgmc155 217 30 p p NN cord-267001-csgmc155 217 31 = = SYM cord-267001-csgmc155 217 32 0.829 0.829 CD cord-267001-csgmc155 217 33 ; ; : cord-267001-csgmc155 217 34 Figure figure NN cord-267001-csgmc155 217 35 5D 5d CD cord-267001-csgmc155 217 36 ) ) -RRB- cord-267001-csgmc155 217 37 . . . cord-267001-csgmc155 217 38 " " '' cord-267001-csgmc155 218 1 − − NNP cord-267001-csgmc155 218 2 " " `` cord-267001-csgmc155 218 3 indicates indicate VBZ cord-267001-csgmc155 218 4 the the DT cord-267001-csgmc155 218 5 absence absence NN cord-267001-csgmc155 218 6 of of IN cord-267001-csgmc155 218 7 the the DT cord-267001-csgmc155 218 8 protein protein NN cord-267001-csgmc155 218 9 or or CC cord-267001-csgmc155 218 10 adjuvants adjuvant NNS cord-267001-csgmc155 218 11 in in IN cord-267001-csgmc155 218 12 the the DT cord-267001-csgmc155 218 13 formulation formulation NN cord-267001-csgmc155 218 14 . . . cord-267001-csgmc155 219 1 Statistics statistic NNS cord-267001-csgmc155 219 2 was be VBD cord-267001-csgmc155 219 3 performed perform VBN cord-267001-csgmc155 219 4 using use VBG cord-267001-csgmc155 219 5 one one CD cord-267001-csgmc155 219 6 - - HYPH cord-267001-csgmc155 219 7 way way NN cord-267001-csgmc155 219 8 ANOVA anova NN cord-267001-csgmc155 219 9 with with IN cord-267001-csgmc155 219 10 Tukey Tukey NNP cord-267001-csgmc155 219 11 's 's POS cord-267001-csgmc155 219 12 multiple multiple JJ cord-267001-csgmc155 219 13 comparison comparison NN cord-267001-csgmc155 219 14 . . . cord-267001-csgmc155 220 1 p p NN cord-267001-csgmc155 220 2 < < XX cord-267001-csgmc155 220 3 0.05 0.05 CD cord-267001-csgmc155 220 4 : : : cord-267001-csgmc155 221 1 * * NFP cord-267001-csgmc155 221 2 , , , cord-267001-csgmc155 221 3 p p NN cord-267001-csgmc155 221 4 < < XX cord-267001-csgmc155 221 5 0.001 0.001 CD cord-267001-csgmc155 221 6 : : : cord-267001-csgmc155 222 1 * * NFP cord-267001-csgmc155 222 2 * * NFP cord-267001-csgmc155 222 3 * * NFP cord-267001-csgmc155 222 4 . . . cord-267001-csgmc155 223 1 Spearman Spearman NNP cord-267001-csgmc155 223 2 correlation correlation NN cord-267001-csgmc155 223 3 was be VBD cord-267001-csgmc155 223 4 performed perform VBN cord-267001-csgmc155 223 5 to to TO cord-267001-csgmc155 223 6 determine determine VB cord-267001-csgmc155 223 7 the the DT cord-267001-csgmc155 223 8 association association NNP cord-267001-csgmc155 223 9 of of IN cord-267001-csgmc155 223 10 TfH TfH NNP cord-267001-csgmc155 223 11 cells cell NNS cord-267001-csgmc155 223 12 with with IN cord-267001-csgmc155 223 13 neutralizing neutralize VBG cord-267001-csgmc155 223 14 antibody antibody NN cord-267001-csgmc155 223 15 titers titer NNS cord-267001-csgmc155 223 16 . . . cord-267001-csgmc155 223 17 _SP cord-267001-csgmc155 224 1 Adjuvants adjuvant NNS cord-267001-csgmc155 224 2 are be VBP cord-267001-csgmc155 224 3 essential essential JJ cord-267001-csgmc155 224 4 components component NNS cord-267001-csgmc155 224 5 in in IN cord-267001-csgmc155 224 6 both both CC cord-267001-csgmc155 224 7 prophylactic prophylactic JJ cord-267001-csgmc155 224 8 and and CC cord-267001-csgmc155 224 9 therapeutic therapeutic JJ cord-267001-csgmc155 224 10 vaccines vaccine NNS cord-267001-csgmc155 224 11 since since IN cord-267001-csgmc155 224 12 they -PRON- PRP cord-267001-csgmc155 224 13 ameliorate ameliorate VBP cord-267001-csgmc155 224 14 antigen antigen NN cord-267001-csgmc155 224 15 - - HYPH cord-267001-csgmc155 224 16 specific specific JJ cord-267001-csgmc155 224 17 protective protective JJ cord-267001-csgmc155 224 18 immune immune JJ cord-267001-csgmc155 224 19 responses response NNS cord-267001-csgmc155 224 20 [ [ -LRB- cord-267001-csgmc155 224 21 28 28 CD cord-267001-csgmc155 224 22 ] ] -RRB- cord-267001-csgmc155 224 23 . . . cord-267001-csgmc155 225 1 However however RB cord-267001-csgmc155 225 2 , , , cord-267001-csgmc155 225 3 choosing choose VBG cord-267001-csgmc155 225 4 the the DT cord-267001-csgmc155 225 5 appropriate appropriate JJ cord-267001-csgmc155 225 6 adjuvant adjuvant NN cord-267001-csgmc155 225 7 that that WDT cord-267001-csgmc155 225 8 can can MD cord-267001-csgmc155 225 9 be be VB cord-267001-csgmc155 225 10 employed employ VBN cord-267001-csgmc155 225 11 safely safely RB cord-267001-csgmc155 225 12 and and CC cord-267001-csgmc155 225 13 that that DT cord-267001-csgmc155 225 14 enhances enhance VBZ cord-267001-csgmc155 225 15 vaccine vaccine NN cord-267001-csgmc155 225 16 efficacy efficacy NN cord-267001-csgmc155 225 17 is be VBZ cord-267001-csgmc155 225 18 still still RB cord-267001-csgmc155 225 19 elusive elusive JJ cord-267001-csgmc155 225 20 and and CC cord-267001-csgmc155 225 21 needs need VBZ cord-267001-csgmc155 225 22 to to TO cord-267001-csgmc155 225 23 be be VB cord-267001-csgmc155 225 24 optimized optimize VBN cord-267001-csgmc155 225 25 experimentally experimentally RB cord-267001-csgmc155 225 26 first first JJ cord-267001-csgmc155 225 27 [ [ -LRB- cord-267001-csgmc155 225 28 29 29 CD cord-267001-csgmc155 225 29 ] ] -RRB- cord-267001-csgmc155 225 30 . . . cord-267001-csgmc155 226 1 Besides besides IN cord-267001-csgmc155 226 2 a a DT cord-267001-csgmc155 226 3 handful handful NN cord-267001-csgmc155 226 4 of of IN cord-267001-csgmc155 226 5 adjuvants adjuvant NNS cord-267001-csgmc155 226 6 such such JJ cord-267001-csgmc155 226 7 as as IN cord-267001-csgmc155 226 8 CPG CPG NNP cord-267001-csgmc155 226 9 , , , cord-267001-csgmc155 226 10 Poly Poly NNP cord-267001-csgmc155 226 11 I i NN cord-267001-csgmc155 226 12 : : : cord-267001-csgmc155 226 13 C C NNP cord-267001-csgmc155 226 14 , , , cord-267001-csgmc155 226 15 MPLA MPLA NNP cord-267001-csgmc155 226 16 and and CC cord-267001-csgmc155 226 17 MF59 MF59 NNP cord-267001-csgmc155 226 18 , , , cord-267001-csgmc155 226 19 aluminum aluminum NN cord-267001-csgmc155 226 20 - - HYPH cord-267001-csgmc155 226 21 based base VBN cord-267001-csgmc155 226 22 ( ( -LRB- cord-267001-csgmc155 226 23 alum alum NN cord-267001-csgmc155 226 24 ) ) -RRB- cord-267001-csgmc155 226 25 adjuvants adjuvant NNS cord-267001-csgmc155 226 26 are be VBP cord-267001-csgmc155 226 27 being be VBG cord-267001-csgmc155 226 28 used use VBN cord-267001-csgmc155 226 29 in in IN cord-267001-csgmc155 226 30 most most JJS cord-267001-csgmc155 226 31 of of IN cord-267001-csgmc155 226 32 the the DT cord-267001-csgmc155 226 33 adjuvanted adjuvante VBN cord-267001-csgmc155 226 34 vaccines vaccine NNS cord-267001-csgmc155 226 35 for for IN cord-267001-csgmc155 226 36 humans human NNS cord-267001-csgmc155 226 37 globally globally RB cord-267001-csgmc155 226 38 even even RB cord-267001-csgmc155 226 39 today today NN cord-267001-csgmc155 226 40 since since IN cord-267001-csgmc155 226 41 its -PRON- PRP$ cord-267001-csgmc155 226 42 inception inception NN cord-267001-csgmc155 226 43 85 85 CD cord-267001-csgmc155 226 44 years year NNS cord-267001-csgmc155 226 45 ago ago RB cord-267001-csgmc155 226 46 [ [ -LRB- cord-267001-csgmc155 226 47 30 30 CD cord-267001-csgmc155 226 48 ] ] -RRB- cord-267001-csgmc155 226 49 . . . cord-267001-csgmc155 227 1 Although although IN cord-267001-csgmc155 227 2 beneficial beneficial JJ cord-267001-csgmc155 227 3 effects effect NNS cord-267001-csgmc155 227 4 of of IN cord-267001-csgmc155 227 5 alum alum NN cord-267001-csgmc155 227 6 as as IN cord-267001-csgmc155 227 7 an an DT cord-267001-csgmc155 227 8 adjuvant adjuvant NN cord-267001-csgmc155 227 9 were be VBD cord-267001-csgmc155 227 10 observed observe VBN cord-267001-csgmc155 227 11 with with IN cord-267001-csgmc155 227 12 the the DT cord-267001-csgmc155 227 13 DTap DTap NNP cord-267001-csgmc155 227 14 , , , cord-267001-csgmc155 227 15 HepB HepB NNP cord-267001-csgmc155 227 16 , , , cord-267001-csgmc155 227 17 and and CC cord-267001-csgmc155 227 18 HepA HepA NNP cord-267001-csgmc155 227 19 vaccines vaccine NNS cord-267001-csgmc155 227 20 , , , cord-267001-csgmc155 227 21 a a DT cord-267001-csgmc155 227 22 biased biased JJ cord-267001-csgmc155 227 23 Th2-type Th2-type NNP cord-267001-csgmc155 227 24 immune immune JJ cord-267001-csgmc155 227 25 response response NN cord-267001-csgmc155 227 26 , , , cord-267001-csgmc155 227 27 absence absence NN cord-267001-csgmc155 227 28 of of IN cord-267001-csgmc155 227 29 strong strong JJ cord-267001-csgmc155 227 30 cellular cellular JJ cord-267001-csgmc155 227 31 responses response NNS cord-267001-csgmc155 227 32 , , , cord-267001-csgmc155 227 33 and and CC cord-267001-csgmc155 227 34 the the DT cord-267001-csgmc155 227 35 induction induction NN cord-267001-csgmc155 227 36 of of IN cord-267001-csgmc155 227 37 adverse adverse JJ cord-267001-csgmc155 227 38 reactions reaction NNS cord-267001-csgmc155 227 39 were be VBD cord-267001-csgmc155 227 40 some some DT cord-267001-csgmc155 227 41 of of IN cord-267001-csgmc155 227 42 the the DT cord-267001-csgmc155 227 43 limitations limitation NNS cord-267001-csgmc155 227 44 found find VBN cord-267001-csgmc155 227 45 with with IN cord-267001-csgmc155 227 46 the the DT cord-267001-csgmc155 227 47 various various JJ cord-267001-csgmc155 227 48 alum alum NN cord-267001-csgmc155 227 49 - - HYPH cord-267001-csgmc155 227 50 adjuvanted adjuvante VBN cord-267001-csgmc155 227 51 vaccines vaccine NNS cord-267001-csgmc155 227 52 [ [ -LRB- cord-267001-csgmc155 227 53 30 30 CD cord-267001-csgmc155 227 54 ] ] -RRB- cord-267001-csgmc155 227 55 . . . cord-267001-csgmc155 228 1 Therefore therefore RB cord-267001-csgmc155 228 2 , , , cord-267001-csgmc155 228 3 the the DT cord-267001-csgmc155 228 4 utilization utilization NN cord-267001-csgmc155 228 5 of of IN cord-267001-csgmc155 228 6 a a DT cord-267001-csgmc155 228 7 combination combination NN cord-267001-csgmc155 228 8 of of IN cord-267001-csgmc155 228 9 adjuvants adjuvant NNS cord-267001-csgmc155 228 10 in in IN cord-267001-csgmc155 228 11 vaccines vaccine NNS cord-267001-csgmc155 228 12 that that WDT cord-267001-csgmc155 228 13 can can MD cord-267001-csgmc155 228 14 improve improve VB cord-267001-csgmc155 228 15 the the DT cord-267001-csgmc155 228 16 safety safety NN cord-267001-csgmc155 228 17 and and CC cord-267001-csgmc155 228 18 efficacy efficacy NN cord-267001-csgmc155 228 19 of of IN cord-267001-csgmc155 228 20 vaccines vaccine NNS cord-267001-csgmc155 228 21 against against IN cord-267001-csgmc155 228 22 emerging emerge VBG cord-267001-csgmc155 228 23 pathogens pathogen NNS cord-267001-csgmc155 228 24 is be VBZ cord-267001-csgmc155 228 25 being be VBG cord-267001-csgmc155 228 26 actively actively RB cord-267001-csgmc155 228 27 pursued pursue VBN cord-267001-csgmc155 228 28 by by IN cord-267001-csgmc155 228 29 the the DT cord-267001-csgmc155 228 30 research research NN cord-267001-csgmc155 228 31 community community NN cord-267001-csgmc155 228 32 [ [ -LRB- cord-267001-csgmc155 228 33 31 31 CD cord-267001-csgmc155 228 34 ] ] -RRB- cord-267001-csgmc155 228 35 . . . cord-267001-csgmc155 229 1 The the DT cord-267001-csgmc155 229 2 use use NN cord-267001-csgmc155 229 3 of of IN cord-267001-csgmc155 229 4 combinatorial combinatorial JJ cord-267001-csgmc155 229 5 adjuvant adjuvant NN cord-267001-csgmc155 229 6 system system NN cord-267001-csgmc155 229 7 is be VBZ cord-267001-csgmc155 229 8 beneficial beneficial JJ cord-267001-csgmc155 229 9 since since IN cord-267001-csgmc155 229 10 they -PRON- PRP cord-267001-csgmc155 229 11 can can MD cord-267001-csgmc155 229 12 be be VB cord-267001-csgmc155 229 13 tailored tailor VBN cord-267001-csgmc155 229 14 to to TO cord-267001-csgmc155 229 15 target target VB cord-267001-csgmc155 229 16 varied varied JJ cord-267001-csgmc155 229 17 pattern pattern NN cord-267001-csgmc155 229 18 - - HYPH cord-267001-csgmc155 229 19 recognition recognition NN cord-267001-csgmc155 229 20 receptors receptor NNS cord-267001-csgmc155 229 21 ( ( -LRB- cord-267001-csgmc155 229 22 PRRs PRRs NNP cord-267001-csgmc155 229 23 ) ) -RRB- cord-267001-csgmc155 229 24 with with IN cord-267001-csgmc155 229 25 each each DT cord-267001-csgmc155 229 26 being be VBG cord-267001-csgmc155 229 27 able able JJ cord-267001-csgmc155 229 28 to to TO cord-267001-csgmc155 229 29 enhance enhance VB cord-267001-csgmc155 229 30 antigen antigen NN cord-267001-csgmc155 229 31 - - HYPH cord-267001-csgmc155 229 32 specific specific JJ cord-267001-csgmc155 229 33 responses response NNS cord-267001-csgmc155 229 34 ( ( -LRB- cord-267001-csgmc155 229 35 cellular cellular JJ cord-267001-csgmc155 229 36 and and CC cord-267001-csgmc155 229 37 humoral humoral JJ cord-267001-csgmc155 229 38 ) ) -RRB- cord-267001-csgmc155 229 39 in in IN cord-267001-csgmc155 229 40 a a DT cord-267001-csgmc155 229 41 complementary complementary JJ cord-267001-csgmc155 229 42 or or CC cord-267001-csgmc155 229 43 synergistic synergistic JJ cord-267001-csgmc155 229 44 outcome outcome NN cord-267001-csgmc155 229 45 [ [ -LRB- cord-267001-csgmc155 229 46 32 32 CD cord-267001-csgmc155 229 47 ] ] -RRB- cord-267001-csgmc155 229 48 . . . cord-267001-csgmc155 230 1 For for IN cord-267001-csgmc155 230 2 instance instance NN cord-267001-csgmc155 230 3 , , , cord-267001-csgmc155 230 4 intranasal intranasal NN cord-267001-csgmc155 230 5 vaccination vaccination NN cord-267001-csgmc155 230 6 with with IN cord-267001-csgmc155 230 7 emulsified emulsify VBN cord-267001-csgmc155 230 8 fine fine JJ cord-267001-csgmc155 230 9 particles particle NNS cord-267001-csgmc155 230 10 like like IN cord-267001-csgmc155 230 11 PELC PELC NNP cord-267001-csgmc155 230 12 in in IN cord-267001-csgmc155 230 13 combination combination NN cord-267001-csgmc155 230 14 with with IN cord-267001-csgmc155 230 15 LD LD NNP cord-267001-csgmc155 230 16 - - HYPH cord-267001-csgmc155 230 17 indolicidin indolicidin NNP cord-267001-csgmc155 230 18 enhanced enhance VBN cord-267001-csgmc155 230 19 protective protective JJ cord-267001-csgmc155 230 20 influenza influenza NN cord-267001-csgmc155 230 21 - - HYPH cord-267001-csgmc155 230 22 specific specific JJ cord-267001-csgmc155 230 23 serological serological JJ cord-267001-csgmc155 230 24 immunity immunity NN cord-267001-csgmc155 230 25 in in IN cord-267001-csgmc155 230 26 mice mouse NNS cord-267001-csgmc155 230 27 [ [ -LRB- cord-267001-csgmc155 230 28 33 33 CD cord-267001-csgmc155 230 29 ] ] -RRB- cord-267001-csgmc155 230 30 . . . cord-267001-csgmc155 231 1 MPL MPL NNP cord-267001-csgmc155 231 2 and and CC cord-267001-csgmc155 231 3 CpG CpG NNP cord-267001-csgmc155 231 4 combination combination NN cord-267001-csgmc155 231 5 adjuvants adjuvant NNS cord-267001-csgmc155 231 6 promoted promote VBD cord-267001-csgmc155 231 7 homologous homologous JJ cord-267001-csgmc155 231 8 and and CC cord-267001-csgmc155 231 9 heterosubtypic heterosubtypic NNP cord-267001-csgmc155 231 10 cross cross NNP cord-267001-csgmc155 231 11 protection protection NN cord-267001-csgmc155 231 12 when when WRB cord-267001-csgmc155 231 13 used use VBN cord-267001-csgmc155 231 14 with with IN cord-267001-csgmc155 231 15 the the DT cord-267001-csgmc155 231 16 inactivated inactivate VBN cord-267001-csgmc155 231 17 split split NN cord-267001-csgmc155 231 18 influenza influenza NN cord-267001-csgmc155 231 19 virus virus NN cord-267001-csgmc155 231 20 vaccine vaccine NN cord-267001-csgmc155 231 21 [ [ -LRB- cord-267001-csgmc155 231 22 34 34 CD cord-267001-csgmc155 231 23 ] ] -RRB- cord-267001-csgmc155 231 24 . . . cord-267001-csgmc155 232 1 The the DT cord-267001-csgmc155 232 2 co co NN cord-267001-csgmc155 232 3 - - NN cord-267001-csgmc155 232 4 administration administration NN cord-267001-csgmc155 232 5 of of IN cord-267001-csgmc155 232 6 alum alum NN cord-267001-csgmc155 232 7 and and CC cord-267001-csgmc155 232 8 a a DT cord-267001-csgmc155 232 9 TLR-7 TLR-7 NNP cord-267001-csgmc155 232 10 adjuvant adjuvant JJ cord-267001-csgmc155 232 11 enhanced enhance VBN cord-267001-csgmc155 232 12 memory memory NN cord-267001-csgmc155 232 13 B b NN cord-267001-csgmc155 232 14 cell cell NN cord-267001-csgmc155 232 15 response response NN cord-267001-csgmc155 232 16 to to IN cord-267001-csgmc155 232 17 lymphocytic lymphocytic JJ cord-267001-csgmc155 232 18 choriomeningitis choriomeningitis NNP cord-267001-csgmc155 232 19 virus virus NN cord-267001-csgmc155 232 20 ( ( -LRB- cord-267001-csgmc155 232 21 LCMV LCMV NNP cord-267001-csgmc155 232 22 ) ) -RRB- cord-267001-csgmc155 232 23 antigen antigen NN cord-267001-csgmc155 232 24 [ [ -LRB- cord-267001-csgmc155 232 25 35 35 CD cord-267001-csgmc155 232 26 ] ] -RRB- cord-267001-csgmc155 232 27 . . . cord-267001-csgmc155 233 1 Alum alum NN cord-267001-csgmc155 233 2 in in IN cord-267001-csgmc155 233 3 combination combination NN cord-267001-csgmc155 233 4 with with IN cord-267001-csgmc155 233 5 MPLA MPLA NNP cord-267001-csgmc155 233 6 - - HYPH cord-267001-csgmc155 233 7 HA HA NNP cord-267001-csgmc155 233 8 - - HYPH cord-267001-csgmc155 233 9 adjuvanted adjuvante VBN cord-267001-csgmc155 233 10 HBsAg HBsAg NNP cord-267001-csgmc155 233 11 increased increase VBD cord-267001-csgmc155 233 12 both both CC cord-267001-csgmc155 233 13 the the DT cord-267001-csgmc155 233 14 magnitude magnitude NN cord-267001-csgmc155 233 15 and and CC cord-267001-csgmc155 233 16 the the DT cord-267001-csgmc155 233 17 persistence persistence NN cord-267001-csgmc155 233 18 of of IN cord-267001-csgmc155 233 19 HBsAg HBsAg NNP cord-267001-csgmc155 233 20 - - HYPH cord-267001-csgmc155 233 21 specific specific JJ cord-267001-csgmc155 233 22 immune immune JJ cord-267001-csgmc155 233 23 responses response NNS cord-267001-csgmc155 233 24 against against IN cord-267001-csgmc155 233 25 hepatitis hepatitis NN cord-267001-csgmc155 233 26 B B NNP cord-267001-csgmc155 233 27 virus virus NN cord-267001-csgmc155 233 28 infection infection NN cord-267001-csgmc155 233 29 [ [ -LRB- cord-267001-csgmc155 233 30 36 36 CD cord-267001-csgmc155 233 31 ] ] -RRB- cord-267001-csgmc155 233 32 . . . cord-267001-csgmc155 234 1 The the DT cord-267001-csgmc155 234 2 aim aim NN cord-267001-csgmc155 234 3 of of IN cord-267001-csgmc155 234 4 the the DT cord-267001-csgmc155 234 5 present present JJ cord-267001-csgmc155 234 6 study study NN cord-267001-csgmc155 234 7 was be VBD cord-267001-csgmc155 234 8 to to TO cord-267001-csgmc155 234 9 explore explore VB cord-267001-csgmc155 234 10 the the DT cord-267001-csgmc155 234 11 synergistic synergistic JJ cord-267001-csgmc155 234 12 potential potential NN cord-267001-csgmc155 234 13 of of IN cord-267001-csgmc155 234 14 combining combine VBG cord-267001-csgmc155 234 15 the the DT cord-267001-csgmc155 234 16 O. O. NNP cord-267001-csgmc155 234 17 volvulus volvulus NN cord-267001-csgmc155 234 18 - - HYPH cord-267001-csgmc155 234 19 derived derive VBN cord-267001-csgmc155 234 20 protein protein NN cord-267001-csgmc155 234 21 adjuvant adjuvant NN cord-267001-csgmc155 234 22 , , , cord-267001-csgmc155 234 23 rASP-1 rASP-1 VBN cord-267001-csgmc155 234 24 with with IN cord-267001-csgmc155 234 25 alum alum NN cord-267001-csgmc155 234 26 as as IN cord-267001-csgmc155 234 27 a a DT cord-267001-csgmc155 234 28 novel novel JJ cord-267001-csgmc155 234 29 combinatorial combinatorial JJ cord-267001-csgmc155 234 30 adjuvant adjuvant NN cord-267001-csgmc155 234 31 system system NN cord-267001-csgmc155 234 32 using use VBG cord-267001-csgmc155 234 33 MERS MERS NNP cord-267001-csgmc155 234 34 - - HYPH cord-267001-csgmc155 234 35 RBD RBD NNP cord-267001-csgmc155 234 36 - - HYPH cord-267001-csgmc155 234 37 Fd Fd NNP cord-267001-csgmc155 234 38 as as IN cord-267001-csgmc155 234 39 the the DT cord-267001-csgmc155 234 40 model model NN cord-267001-csgmc155 234 41 vaccine vaccine NN cord-267001-csgmc155 234 42 antigen antigen NN cord-267001-csgmc155 234 43 . . . cord-267001-csgmc155 235 1 We -PRON- PRP cord-267001-csgmc155 235 2 have have VBP cord-267001-csgmc155 235 3 previously previously RB cord-267001-csgmc155 235 4 shown show VBN cord-267001-csgmc155 235 5 that that IN cord-267001-csgmc155 235 6 rASP-1 rasp-1 PRP cord-267001-csgmc155 235 7 enhances enhance VBZ cord-267001-csgmc155 235 8 the the DT cord-267001-csgmc155 235 9 immune immune JJ cord-267001-csgmc155 235 10 response response NN cord-267001-csgmc155 235 11 when when WRB cord-267001-csgmc155 235 12 co co NN cord-267001-csgmc155 235 13 - - VBN cord-267001-csgmc155 235 14 administered administer VBN cord-267001-csgmc155 235 15 in in IN cord-267001-csgmc155 235 16 an an DT cord-267001-csgmc155 235 17 aqueous aqueous JJ cord-267001-csgmc155 235 18 formulation formulation NN cord-267001-csgmc155 235 19 with with IN cord-267001-csgmc155 235 20 several several JJ cord-267001-csgmc155 235 21 bystander bystander NN cord-267001-csgmc155 235 22 vaccine vaccine NN cord-267001-csgmc155 235 23 antigens antigen NNS cord-267001-csgmc155 235 24 [ [ -LRB- cord-267001-csgmc155 235 25 9 9 CD cord-267001-csgmc155 235 26 ] ] -RRB- cord-267001-csgmc155 235 27 [ [ -LRB- cord-267001-csgmc155 235 28 10 10 CD cord-267001-csgmc155 235 29 ] ] -RRB- cord-267001-csgmc155 235 30 [ [ -LRB- cord-267001-csgmc155 235 31 11 11 CD cord-267001-csgmc155 235 32 ] ] -RRB- cord-267001-csgmc155 235 33 . . . cord-267001-csgmc155 236 1 Moreover moreover RB cord-267001-csgmc155 236 2 , , , cord-267001-csgmc155 236 3 we -PRON- PRP cord-267001-csgmc155 236 4 have have VBP cord-267001-csgmc155 236 5 also also RB cord-267001-csgmc155 236 6 reported report VBN cord-267001-csgmc155 236 7 that that IN cord-267001-csgmc155 236 8 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 236 9 trivalent trivalent JJ cord-267001-csgmc155 236 10 influenza influenza NN cord-267001-csgmc155 236 11 vaccine vaccine NN cord-267001-csgmc155 236 12 ( ( -LRB- cord-267001-csgmc155 236 13 IIV3 IIV3 NNP cord-267001-csgmc155 236 14 ) ) -RRB- cord-267001-csgmc155 236 15 elicits elicit VBZ cord-267001-csgmc155 236 16 a a DT cord-267001-csgmc155 236 17 balanced balanced JJ cord-267001-csgmc155 236 18 IgG1 IgG1 NNP cord-267001-csgmc155 236 19 / / SYM cord-267001-csgmc155 236 20 IgG2c IgG2c NNP cord-267001-csgmc155 236 21 response response NN cord-267001-csgmc155 236 22 to to IN cord-267001-csgmc155 236 23 IIV3 IIV3 NNP cord-267001-csgmc155 236 24 and and CC cord-267001-csgmc155 236 25 protects protect VBZ cord-267001-csgmc155 236 26 mice mouse NNS cord-267001-csgmc155 236 27 following follow VBG cord-267001-csgmc155 236 28 H1N1 H1N1 NNP cord-267001-csgmc155 236 29 virus virus NN cord-267001-csgmc155 236 30 challenge challenge NN cord-267001-csgmc155 236 31 , , , cord-267001-csgmc155 236 32 potentially potentially RB cord-267001-csgmc155 236 33 via via IN cord-267001-csgmc155 236 34 MyD88-independent MyD88-independent NNP cord-267001-csgmc155 236 35 TLR4 TLR4 NNP cord-267001-csgmc155 237 1 signaling signal VBG cord-267001-csgmc155 237 2 [ [ -LRB- cord-267001-csgmc155 237 3 8 8 CD cord-267001-csgmc155 237 4 , , , cord-267001-csgmc155 237 5 12 12 CD cord-267001-csgmc155 237 6 ] ] -RRB- cord-267001-csgmc155 237 7 . . . cord-267001-csgmc155 238 1 In in IN cord-267001-csgmc155 238 2 this this DT cord-267001-csgmc155 238 3 study study NN cord-267001-csgmc155 238 4 , , , cord-267001-csgmc155 238 5 we -PRON- PRP cord-267001-csgmc155 238 6 have have VBP cord-267001-csgmc155 238 7 shown show VBN cord-267001-csgmc155 238 8 that that IN cord-267001-csgmc155 238 9 mice mouse NNS cord-267001-csgmc155 238 10 immunized immunize VBN cord-267001-csgmc155 238 11 with with IN cord-267001-csgmc155 238 12 RBD RBD NNP cord-267001-csgmc155 238 13 + + CC cord-267001-csgmc155 239 1 rASP-1 rasp-1 LS cord-267001-csgmc155 239 2 + + CC cord-267001-csgmc155 239 3 alum alum NN cord-267001-csgmc155 239 4 in in IN cord-267001-csgmc155 239 5 a a DT cord-267001-csgmc155 239 6 single single JJ cord-267001-csgmc155 239 7 inoculum inoculum NN cord-267001-csgmc155 239 8 elicited elicit VBD cord-267001-csgmc155 239 9 neutralizing neutralize VBG cord-267001-csgmc155 239 10 antibody antibody NN cord-267001-csgmc155 239 11 titers titer NNS cord-267001-csgmc155 239 12 against against IN cord-267001-csgmc155 239 13 pseudotyped pseudotyped NNP cord-267001-csgmc155 239 14 MERS MERS NNP cord-267001-csgmc155 239 15 - - HYPH cord-267001-csgmc155 239 16 CoV CoV NNP cord-267001-csgmc155 239 17 that that WDT cord-267001-csgmc155 239 18 were be VBD cord-267001-csgmc155 239 19 not not RB cord-267001-csgmc155 239 20 significantly significantly RB cord-267001-csgmc155 239 21 different different JJ cord-267001-csgmc155 239 22 from from IN cord-267001-csgmc155 239 23 mice mouse NNS cord-267001-csgmc155 239 24 that that WDT cord-267001-csgmc155 239 25 received receive VBD cord-267001-csgmc155 239 26 either either RB cord-267001-csgmc155 239 27 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 240 1 RBD RBD NNP cord-267001-csgmc155 240 2 vaccine vaccine NN cord-267001-csgmc155 240 3 or or CC cord-267001-csgmc155 240 4 alum alum NN cord-267001-csgmc155 240 5 - - HYPH cord-267001-csgmc155 240 6 adjuvanted adjuvante VBN cord-267001-csgmc155 240 7 RBD RBD NNP cord-267001-csgmc155 240 8 vaccine vaccine NN cord-267001-csgmc155 240 9 alone alone RB cord-267001-csgmc155 241 1 ( ( -LRB- cord-267001-csgmc155 241 2 Figure figure NN cord-267001-csgmc155 241 3 1 1 CD cord-267001-csgmc155 241 4 ) ) -RRB- cord-267001-csgmc155 241 5 . . . cord-267001-csgmc155 242 1 Notably notably RB cord-267001-csgmc155 242 2 , , , cord-267001-csgmc155 242 3 when when WRB cord-267001-csgmc155 242 4 rASP-1 rasp-1 ADD cord-267001-csgmc155 242 5 and and CC cord-267001-csgmc155 242 6 the the DT cord-267001-csgmc155 242 7 alum alum NN cord-267001-csgmc155 242 8 - - HYPH cord-267001-csgmc155 242 9 adjuvanted adjuvante VBN cord-267001-csgmc155 242 10 RBD RBD NNP cord-267001-csgmc155 242 11 vaccine vaccine NN cord-267001-csgmc155 242 12 were be VBD cord-267001-csgmc155 242 13 co co VBN cord-267001-csgmc155 242 14 - - VBN cord-267001-csgmc155 242 15 administered administer VBN cord-267001-csgmc155 242 16 in in IN cord-267001-csgmc155 242 17 separate separate JJ cord-267001-csgmc155 242 18 sites site NNS cord-267001-csgmc155 242 19 the the DT cord-267001-csgmc155 242 20 vaccine vaccine NN cord-267001-csgmc155 242 21 ameliorated ameliorate VBD cord-267001-csgmc155 242 22 the the DT cord-267001-csgmc155 242 23 production production NN cord-267001-csgmc155 242 24 of of IN cord-267001-csgmc155 242 25 neutralizing neutralize VBG cord-267001-csgmc155 242 26 antibody antibody NN cord-267001-csgmc155 242 27 titers titer NNS cord-267001-csgmc155 242 28 by~4-fold by~4-fold RB cord-267001-csgmc155 242 29 as as IN cord-267001-csgmc155 242 30 compared compare VBN cord-267001-csgmc155 242 31 to to IN cord-267001-csgmc155 242 32 the the DT cord-267001-csgmc155 242 33 combinatorial combinatorial JJ cord-267001-csgmc155 242 34 adjuvant adjuvant NN cord-267001-csgmc155 242 35 system system NN cord-267001-csgmc155 242 36 administered administer VBN cord-267001-csgmc155 242 37 in in IN cord-267001-csgmc155 242 38 a a DT cord-267001-csgmc155 242 39 single single JJ cord-267001-csgmc155 242 40 inoculum inoculum NN cord-267001-csgmc155 242 41 ( ( -LRB- cord-267001-csgmc155 242 42 Figure figure NN cord-267001-csgmc155 242 43 1 1 CD cord-267001-csgmc155 242 44 ) ) -RRB- cord-267001-csgmc155 242 45 . . . cord-267001-csgmc155 243 1 We -PRON- PRP cord-267001-csgmc155 243 2 also also RB cord-267001-csgmc155 243 3 observed observe VBD cord-267001-csgmc155 243 4 that that IN cord-267001-csgmc155 243 5 mice mouse NNS cord-267001-csgmc155 243 6 that that WDT cord-267001-csgmc155 243 7 received receive VBD cord-267001-csgmc155 243 8 two two CD cord-267001-csgmc155 243 9 immunizations immunization NNS cord-267001-csgmc155 243 10 at at IN cord-267001-csgmc155 243 11 three three CD cord-267001-csgmc155 243 12 - - HYPH cord-267001-csgmc155 243 13 week week NN cord-267001-csgmc155 243 14 intervals interval NNS cord-267001-csgmc155 243 15 of of IN cord-267001-csgmc155 243 16 the the DT cord-267001-csgmc155 243 17 combinatorial combinatorial JJ cord-267001-csgmc155 243 18 adjuvant adjuvant NN cord-267001-csgmc155 243 19 system system NN cord-267001-csgmc155 244 1 where where WRB cord-267001-csgmc155 244 2 rASP-1 rasp-1 VB cord-267001-csgmc155 244 3 and and CC cord-267001-csgmc155 244 4 the the DT cord-267001-csgmc155 244 5 alum alum NN cord-267001-csgmc155 244 6 - - HYPH cord-267001-csgmc155 244 7 adjuvanted adjuvante VBN cord-267001-csgmc155 244 8 RBD RBD NNP cord-267001-csgmc155 244 9 vaccine vaccine NN cord-267001-csgmc155 244 10 were be VBD cord-267001-csgmc155 244 11 co co VBN cord-267001-csgmc155 244 12 - - VBN cord-267001-csgmc155 244 13 administered administer VBN cord-267001-csgmc155 244 14 separately separately RB cord-267001-csgmc155 244 15 elicited elicit VBD cord-267001-csgmc155 244 16 neutralizing neutralize VBG cord-267001-csgmc155 244 17 antibody antibody NN cord-267001-csgmc155 244 18 titers titer NNS cord-267001-csgmc155 244 19 against against IN cord-267001-csgmc155 244 20 pseudotyped pseudotyped NNP cord-267001-csgmc155 244 21 MERS MERS NNP cord-267001-csgmc155 244 22 - - HYPH cord-267001-csgmc155 244 23 CoV cov NN cord-267001-csgmc155 244 24 infection infection NN cord-267001-csgmc155 244 25 that that WDT cord-267001-csgmc155 244 26 were be VBD cord-267001-csgmc155 244 27 similar similar JJ cord-267001-csgmc155 244 28 to to IN cord-267001-csgmc155 244 29 , , , cord-267001-csgmc155 244 30 or or CC cord-267001-csgmc155 244 31 slightly slightly RB cord-267001-csgmc155 244 32 lower low JJR cord-267001-csgmc155 244 33 than than IN cord-267001-csgmc155 244 34 , , , cord-267001-csgmc155 244 35 those those DT cord-267001-csgmc155 244 36 elicited elicit VBN cord-267001-csgmc155 244 37 in in IN cord-267001-csgmc155 244 38 mice mouse NNS cord-267001-csgmc155 244 39 that that WDT cord-267001-csgmc155 244 40 received receive VBD cord-267001-csgmc155 244 41 three three CD cord-267001-csgmc155 244 42 immunizations immunization NNS cord-267001-csgmc155 244 43 of of IN cord-267001-csgmc155 244 44 the the DT cord-267001-csgmc155 244 45 Montanide Montanide NNP cord-267001-csgmc155 244 46 ISA51-adjuvanted ISA51-adjuvanted NNP cord-267001-csgmc155 244 47 , , , cord-267001-csgmc155 244 48 or or CC cord-267001-csgmc155 244 49 two two CD cord-267001-csgmc155 244 50 immunizations immunization NNS cord-267001-csgmc155 244 51 of of IN cord-267001-csgmc155 244 52 the the DT cord-267001-csgmc155 244 53 MF59-adjuvanted MF59-adjuvanted NNP cord-267001-csgmc155 244 54 MERS MERS NNP cord-267001-csgmc155 244 55 CoV CoV NNP cord-267001-csgmc155 244 56 - - HYPH cord-267001-csgmc155 244 57 RBD RBD NNP cord-267001-csgmc155 244 58 - - HYPH cord-267001-csgmc155 244 59 Fc Fc NNP cord-267001-csgmc155 244 60 or or CC cord-267001-csgmc155 244 61 MERS MERS NNP cord-267001-csgmc155 244 62 - - HYPH cord-267001-csgmc155 244 63 RBD RBD NNP cord-267001-csgmc155 244 64 - - HYPH cord-267001-csgmc155 244 65 Fd Fd NNP cord-267001-csgmc155 244 66 vaccines vaccine NNS cord-267001-csgmc155 244 67 [ [ -LRB- cord-267001-csgmc155 244 68 20 20 CD cord-267001-csgmc155 244 69 ] ] -RRB- cord-267001-csgmc155 244 70 . . . cord-267001-csgmc155 245 1 Another another DT cord-267001-csgmc155 245 2 noteworthy noteworthy JJ cord-267001-csgmc155 245 3 observation observation NN cord-267001-csgmc155 245 4 is be VBZ cord-267001-csgmc155 245 5 that that IN cord-267001-csgmc155 245 6 the the DT cord-267001-csgmc155 245 7 heightened heighten VBN cord-267001-csgmc155 245 8 neutralizing neutralize VBG cord-267001-csgmc155 245 9 antibody antibody NN cord-267001-csgmc155 245 10 titers titer NNS cord-267001-csgmc155 245 11 induced induce VBN cord-267001-csgmc155 245 12 by by IN cord-267001-csgmc155 245 13 the the DT cord-267001-csgmc155 245 14 unique unique JJ cord-267001-csgmc155 245 15 experimental experimental JJ cord-267001-csgmc155 245 16 combinatorial combinatorial JJ cord-267001-csgmc155 245 17 adjuvant adjuvant NN cord-267001-csgmc155 245 18 system system NN cord-267001-csgmc155 245 19 was be VBD cord-267001-csgmc155 245 20 achieved achieve VBN cord-267001-csgmc155 245 21 using use VBG cord-267001-csgmc155 245 22 5 5 CD cord-267001-csgmc155 245 23 µg µg CD cord-267001-csgmc155 245 24 of of IN cord-267001-csgmc155 245 25 the the DT cord-267001-csgmc155 245 26 MERS MERS NNP cord-267001-csgmc155 245 27 - - HYPH cord-267001-csgmc155 245 28 RBD RBD NNP cord-267001-csgmc155 245 29 - - HYPH cord-267001-csgmc155 245 30 Fd Fd NNP cord-267001-csgmc155 245 31 vaccine vaccine NN cord-267001-csgmc155 245 32 protein protein NN cord-267001-csgmc155 245 33 , , , cord-267001-csgmc155 245 34 compared compare VBN cord-267001-csgmc155 245 35 to to IN cord-267001-csgmc155 245 36 10 10 CD cord-267001-csgmc155 245 37 µg µg NN cord-267001-csgmc155 245 38 of of IN cord-267001-csgmc155 245 39 MERS MERS NNP cord-267001-csgmc155 245 40 - - HYPH cord-267001-csgmc155 245 41 RBD RBD NNP cord-267001-csgmc155 245 42 - - HYPH cord-267001-csgmc155 245 43 Fc Fc NNP cord-267001-csgmc155 245 44 or or CC cord-267001-csgmc155 245 45 MERS MERS NNP cord-267001-csgmc155 245 46 - - HYPH cord-267001-csgmc155 245 47 RBD RBD NNP cord-267001-csgmc155 245 48 - - HYPH cord-267001-csgmc155 245 49 Fd fd NN cord-267001-csgmc155 245 50 proteins protein NNS cord-267001-csgmc155 245 51 used use VBN cord-267001-csgmc155 245 52 in in IN cord-267001-csgmc155 245 53 previous previous JJ cord-267001-csgmc155 245 54 studies study NNS cord-267001-csgmc155 245 55 [ [ -LRB- cord-267001-csgmc155 245 56 20 20 CD cord-267001-csgmc155 245 57 ] ] -RRB- cord-267001-csgmc155 245 58 . . . cord-267001-csgmc155 246 1 This this DT cord-267001-csgmc155 246 2 suggests suggest VBZ cord-267001-csgmc155 246 3 that that IN cord-267001-csgmc155 246 4 the the DT cord-267001-csgmc155 246 5 rASP-1 rasp-1 NN cord-267001-csgmc155 246 6 in in IN cord-267001-csgmc155 246 7 this this DT cord-267001-csgmc155 246 8 unique unique JJ cord-267001-csgmc155 246 9 combinatorial combinatorial JJ cord-267001-csgmc155 246 10 adjuvant adjuvant NN cord-267001-csgmc155 246 11 system system NN cord-267001-csgmc155 246 12 enabled enable VBD cord-267001-csgmc155 246 13 also also RB cord-267001-csgmc155 246 14 RBD RBD NNP cord-267001-csgmc155 246 15 dose dose NN cord-267001-csgmc155 246 16 sparing sparing NN cord-267001-csgmc155 246 17 and and CC cord-267001-csgmc155 246 18 with with IN cord-267001-csgmc155 246 19 two two CD cord-267001-csgmc155 246 20 immunizations immunization NNS cord-267001-csgmc155 246 21 . . . cord-267001-csgmc155 247 1 We -PRON- PRP cord-267001-csgmc155 247 2 have have VBP cord-267001-csgmc155 247 3 previously previously RB cord-267001-csgmc155 247 4 reported report VBN cord-267001-csgmc155 247 5 that that IN cord-267001-csgmc155 247 6 rASP-1 rASP-1 : cord-267001-csgmc155 247 7 also also RB cord-267001-csgmc155 247 8 facilitates facilitate VBZ cord-267001-csgmc155 247 9 IIV3 IIV3 NNP cord-267001-csgmc155 247 10 antigen antigen NN cord-267001-csgmc155 247 11 dose dose NN cord-267001-csgmc155 247 12 sparing sparing NN cord-267001-csgmc155 247 13 up up RP cord-267001-csgmc155 247 14 to to IN cord-267001-csgmc155 247 15 a a DT cord-267001-csgmc155 247 16 10-or 10-or CD cord-267001-csgmc155 247 17 40-fold 40-fold CD cord-267001-csgmc155 247 18 decrease decrease NN cord-267001-csgmc155 247 19 , , , cord-267001-csgmc155 247 20 and and CC cord-267001-csgmc155 247 21 with with IN cord-267001-csgmc155 247 22 a a DT cord-267001-csgmc155 247 23 single single JJ cord-267001-csgmc155 247 24 immunization immunization NN cord-267001-csgmc155 247 25 of of IN cord-267001-csgmc155 247 26 the the DT cord-267001-csgmc155 247 27 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 247 28 IIV3 IIV3 NNP cord-267001-csgmc155 247 29 , , , cord-267001-csgmc155 247 30 mice mouse NNS cord-267001-csgmc155 247 31 were be VBD cord-267001-csgmc155 247 32 still still RB cord-267001-csgmc155 247 33 protected protect VBN cord-267001-csgmc155 247 34 from from IN cord-267001-csgmc155 247 35 a a DT cord-267001-csgmc155 247 36 lethal lethal JJ cord-267001-csgmc155 247 37 H1N1 H1N1 NNP cord-267001-csgmc155 247 38 influenza influenza NN cord-267001-csgmc155 247 39 virus virus NN cord-267001-csgmc155 247 40 challenge challenge NN cord-267001-csgmc155 247 41 [ [ -LRB- cord-267001-csgmc155 247 42 12 12 CD cord-267001-csgmc155 247 43 ] ] -RRB- cord-267001-csgmc155 247 44 . . . cord-267001-csgmc155 248 1 Importantly importantly RB cord-267001-csgmc155 248 2 , , , cord-267001-csgmc155 248 3 the the DT cord-267001-csgmc155 248 4 antibodies antibody NNS cord-267001-csgmc155 248 5 elicited elicit VBN cord-267001-csgmc155 248 6 by by IN cord-267001-csgmc155 248 7 the the DT cord-267001-csgmc155 248 8 different different JJ cord-267001-csgmc155 248 9 combinatorial combinatorial JJ cord-267001-csgmc155 248 10 RBD RBD NNP cord-267001-csgmc155 248 11 - - HYPH cord-267001-csgmc155 248 12 adjuvanted adjuvante VBN cord-267001-csgmc155 248 13 vaccines vaccine NNS cord-267001-csgmc155 248 14 were be VBD cord-267001-csgmc155 248 15 also also RB cord-267001-csgmc155 248 16 functional functional JJ cord-267001-csgmc155 248 17 in in IN cord-267001-csgmc155 248 18 their -PRON- PRP$ cord-267001-csgmc155 248 19 ability ability NN cord-267001-csgmc155 248 20 to to TO cord-267001-csgmc155 248 21 inhibit inhibit VB cord-267001-csgmc155 248 22 the the DT cord-267001-csgmc155 248 23 binding binding NN cord-267001-csgmc155 248 24 of of IN cord-267001-csgmc155 248 25 MERS MERS NNP cord-267001-csgmc155 248 26 - - HYPH cord-267001-csgmc155 248 27 RBD RBD NNP cord-267001-csgmc155 248 28 to to IN cord-267001-csgmc155 248 29 the the DT cord-267001-csgmc155 248 30 human human JJ cord-267001-csgmc155 248 31 DPP4 DPP4 NNP cord-267001-csgmc155 248 32 receptor receptor NN cord-267001-csgmc155 248 33 . . . cord-267001-csgmc155 249 1 Mice mouse NNS cord-267001-csgmc155 249 2 that that WDT cord-267001-csgmc155 249 3 received receive VBD cord-267001-csgmc155 249 4 rASP-1 rasp-1 CD cord-267001-csgmc155 249 5 and and CC cord-267001-csgmc155 249 6 the the DT cord-267001-csgmc155 249 7 alum alum NN cord-267001-csgmc155 249 8 - - HYPH cord-267001-csgmc155 249 9 adjuvanted adjuvante VBN cord-267001-csgmc155 249 10 RBD RBD NNP cord-267001-csgmc155 249 11 vaccine vaccine NN cord-267001-csgmc155 249 12 separately separately RB cord-267001-csgmc155 249 13 inhibited inhibit VBD cord-267001-csgmc155 249 14 the the DT cord-267001-csgmc155 249 15 binding binding NN cord-267001-csgmc155 249 16 bỹ bỹ NN cord-267001-csgmc155 249 17 2-fold 2-fold CD cord-267001-csgmc155 249 18 more more JJR cord-267001-csgmc155 249 19 as as IN cord-267001-csgmc155 249 20 compared compare VBN cord-267001-csgmc155 249 21 to to IN cord-267001-csgmc155 249 22 mice mouse NNS cord-267001-csgmc155 249 23 administered administer VBN cord-267001-csgmc155 249 24 with with IN cord-267001-csgmc155 249 25 RBD RBD NNP cord-267001-csgmc155 249 26 rASP-1 rASP-1 NNP cord-267001-csgmc155 250 1 + + CC cord-267001-csgmc155 251 1 alum alum NN cord-267001-csgmc155 251 2 in in IN cord-267001-csgmc155 251 3 a a DT cord-267001-csgmc155 251 4 single single JJ cord-267001-csgmc155 251 5 inoculum inoculum NN cord-267001-csgmc155 251 6 ( ( -LRB- cord-267001-csgmc155 251 7 Figure figure NN cord-267001-csgmc155 251 8 2 2 CD cord-267001-csgmc155 251 9 ) ) -RRB- cord-267001-csgmc155 251 10 . . . cord-267001-csgmc155 252 1 Although although IN cord-267001-csgmc155 252 2 mice mouse NNS cord-267001-csgmc155 252 3 that that WDT cord-267001-csgmc155 252 4 received receive VBD cord-267001-csgmc155 252 5 alum alum NN cord-267001-csgmc155 252 6 - - HYPH cord-267001-csgmc155 252 7 adjuvanted adjuvante VBN cord-267001-csgmc155 252 8 RBD RBD NNP cord-267001-csgmc155 252 9 vaccine vaccine NN cord-267001-csgmc155 252 10 significantly significantly RB cord-267001-csgmc155 252 11 inhibited inhibit VBD cord-267001-csgmc155 252 12 binding bind VBG cord-267001-csgmc155 252 13 ( ( -LRB- cord-267001-csgmc155 252 14 35 35 CD cord-267001-csgmc155 252 15 % % NN cord-267001-csgmc155 252 16 ± ± NNP cord-267001-csgmc155 252 17 2.3 2.3 CD cord-267001-csgmc155 252 18 ) ) -RRB- cord-267001-csgmc155 252 19 compared compare VBD cord-267001-csgmc155 252 20 to to IN cord-267001-csgmc155 252 21 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 252 22 RBD RBD NNP cord-267001-csgmc155 252 23 vaccine vaccine NN cord-267001-csgmc155 252 24 , , , cord-267001-csgmc155 252 25 they -PRON- PRP cord-267001-csgmc155 252 26 were be VBD cord-267001-csgmc155 252 27 not not RB cord-267001-csgmc155 252 28 significantly significantly RB cord-267001-csgmc155 252 29 different different JJ cord-267001-csgmc155 252 30 compared compare VBN cord-267001-csgmc155 252 31 to to IN cord-267001-csgmc155 252 32 the the DT cord-267001-csgmc155 252 33 combinatorial combinatorial JJ cord-267001-csgmc155 252 34 adjuvant adjuvant NN cord-267001-csgmc155 252 35 system system NN cord-267001-csgmc155 252 36 administered administer VBN cord-267001-csgmc155 252 37 in in IN cord-267001-csgmc155 252 38 a a DT cord-267001-csgmc155 252 39 single single JJ cord-267001-csgmc155 252 40 inoculum inoculum NN cord-267001-csgmc155 253 1 ( ( -LRB- cord-267001-csgmc155 253 2 Figure figure NN cord-267001-csgmc155 253 3 2 2 CD cord-267001-csgmc155 253 4 ) ) -RRB- cord-267001-csgmc155 253 5 . . . cord-267001-csgmc155 254 1 The the DT cord-267001-csgmc155 254 2 inhibition inhibition NN cord-267001-csgmc155 254 3 of of IN cord-267001-csgmc155 254 4 binding binding NN cord-267001-csgmc155 254 5 , , , cord-267001-csgmc155 254 6 however however RB cord-267001-csgmc155 254 7 , , , cord-267001-csgmc155 254 8 was be VBD cord-267001-csgmc155 254 9 only only RB cord-267001-csgmc155 254 10 enhanced enhance VBN cord-267001-csgmc155 254 11 in in IN cord-267001-csgmc155 254 12 the the DT cord-267001-csgmc155 254 13 combinatorial combinatorial JJ cord-267001-csgmc155 254 14 adjuvant adjuvant NN cord-267001-csgmc155 254 15 system system NN cord-267001-csgmc155 254 16 where where WRB cord-267001-csgmc155 254 17 rASP-1 rasp-1 NN cord-267001-csgmc155 254 18 and and CC cord-267001-csgmc155 254 19 alum alum NN cord-267001-csgmc155 254 20 - - HYPH cord-267001-csgmc155 254 21 adjuvanted adjuvante VBN cord-267001-csgmc155 254 22 RBD RBD NNP cord-267001-csgmc155 254 23 vaccine vaccine NN cord-267001-csgmc155 254 24 are be VBP cord-267001-csgmc155 254 25 co co VBN cord-267001-csgmc155 254 26 - - VBN cord-267001-csgmc155 254 27 administered administer VBN cord-267001-csgmc155 254 28 separately separately RB cord-267001-csgmc155 254 29 . . . cord-267001-csgmc155 255 1 These these DT cord-267001-csgmc155 255 2 data datum NNS cord-267001-csgmc155 255 3 collectively collectively RB cord-267001-csgmc155 255 4 suggest suggest VBP cord-267001-csgmc155 255 5 that that IN cord-267001-csgmc155 255 6 adsorption adsorption NN cord-267001-csgmc155 255 7 of of IN cord-267001-csgmc155 255 8 rASP-1 rASP-1 NNP cord-267001-csgmc155 255 9 to to IN cord-267001-csgmc155 255 10 alum alum NN cord-267001-csgmc155 255 11 in in IN cord-267001-csgmc155 255 12 a a DT cord-267001-csgmc155 255 13 combinatorial combinatorial JJ cord-267001-csgmc155 255 14 adjuvant adjuvant NN cord-267001-csgmc155 255 15 system system NN cord-267001-csgmc155 255 16 does do VBZ cord-267001-csgmc155 255 17 not not RB cord-267001-csgmc155 255 18 enhance enhance VB cord-267001-csgmc155 255 19 the the DT cord-267001-csgmc155 255 20 functional functional JJ cord-267001-csgmc155 255 21 antibody antibody NN cord-267001-csgmc155 255 22 responses response NNS cord-267001-csgmc155 255 23 elicited elicit VBN cord-267001-csgmc155 255 24 by by IN cord-267001-csgmc155 255 25 alum alum NN cord-267001-csgmc155 255 26 - - HYPH cord-267001-csgmc155 255 27 adjuvanted adjuvante VBN cord-267001-csgmc155 255 28 RBD RBD NNP cord-267001-csgmc155 255 29 vaccine vaccine NN cord-267001-csgmc155 255 30 . . . cord-267001-csgmc155 256 1 While while IN cord-267001-csgmc155 256 2 rASP-1 rasp-1 NN cord-267001-csgmc155 256 3 when when WRB cord-267001-csgmc155 256 4 not not RB cord-267001-csgmc155 256 5 adsorbed adsorb VBN cord-267001-csgmc155 256 6 to to IN cord-267001-csgmc155 256 7 alum alum NN cord-267001-csgmc155 256 8 in in IN cord-267001-csgmc155 256 9 a a DT cord-267001-csgmc155 256 10 combinatorial combinatorial JJ cord-267001-csgmc155 256 11 adjuvant adjuvant NN cord-267001-csgmc155 256 12 system system NN cord-267001-csgmc155 256 13 was be VBD cord-267001-csgmc155 256 14 able able JJ cord-267001-csgmc155 256 15 to to TO cord-267001-csgmc155 256 16 ameliorate ameliorate VB cord-267001-csgmc155 256 17 the the DT cord-267001-csgmc155 256 18 functional functional JJ cord-267001-csgmc155 256 19 antibody antibody NN cord-267001-csgmc155 256 20 responses response NNS cord-267001-csgmc155 256 21 . . . cord-267001-csgmc155 257 1 An an DT cord-267001-csgmc155 257 2 important important JJ cord-267001-csgmc155 257 3 concern concern NN cord-267001-csgmc155 257 4 raised raise VBD cord-267001-csgmc155 257 5 when when WRB cord-267001-csgmc155 257 6 anti anti JJ cord-267001-csgmc155 257 7 - - JJ cord-267001-csgmc155 257 8 viral viral JJ cord-267001-csgmc155 257 9 vaccine vaccine NN cord-267001-csgmc155 257 10 are be VBP cord-267001-csgmc155 257 11 developed develop VBN cord-267001-csgmc155 257 12 , , , cord-267001-csgmc155 257 13 especially especially RB cord-267001-csgmc155 257 14 with with IN cord-267001-csgmc155 257 15 the the DT cord-267001-csgmc155 257 16 ongoing ongoing JJ cord-267001-csgmc155 257 17 COVID-19 COVID-19 NNP cord-267001-csgmc155 257 18 crisis crisis NN cord-267001-csgmc155 257 19 , , , cord-267001-csgmc155 257 20 is be VBZ cord-267001-csgmc155 257 21 that that IN cord-267001-csgmc155 257 22 some some DT cord-267001-csgmc155 257 23 vaccine vaccine NN cord-267001-csgmc155 257 24 approaches approach NNS cord-267001-csgmc155 257 25 may may MD cord-267001-csgmc155 257 26 induce induce VB cord-267001-csgmc155 257 27 unwantedly unwantedly RB cord-267001-csgmc155 257 28 adverse adverse JJ cord-267001-csgmc155 257 29 side side NN cord-267001-csgmc155 257 30 effects effect NNS cord-267001-csgmc155 257 31 due due IN cord-267001-csgmc155 257 32 to to IN cord-267001-csgmc155 257 33 antibody antibody NN cord-267001-csgmc155 257 34 dependent dependent JJ cord-267001-csgmc155 257 35 enhancement enhancement NN cord-267001-csgmc155 257 36 ( ( -LRB- cord-267001-csgmc155 257 37 ADE ADE NNP cord-267001-csgmc155 257 38 ) ) -RRB- cord-267001-csgmc155 257 39 and and CC cord-267001-csgmc155 257 40 thus thus RB cord-267001-csgmc155 257 41 more more RBR cord-267001-csgmc155 257 42 severe severe JJ cord-267001-csgmc155 257 43 pathology pathology NN cord-267001-csgmc155 257 44 [ [ -LRB- cord-267001-csgmc155 257 45 37 37 CD cord-267001-csgmc155 257 46 ] ] -RRB- cord-267001-csgmc155 257 47 . . . cord-267001-csgmc155 258 1 Since since IN cord-267001-csgmc155 258 2 ADE ADE NNP cord-267001-csgmc155 258 3 is be VBZ cord-267001-csgmc155 258 4 generally generally RB cord-267001-csgmc155 258 5 correlated correlate VBN cord-267001-csgmc155 258 6 to to IN cord-267001-csgmc155 258 7 the the DT cord-267001-csgmc155 258 8 neutralizing neutralize VBG cord-267001-csgmc155 258 9 antibody antibody NN cord-267001-csgmc155 258 10 titers titer NNS cord-267001-csgmc155 258 11 , , , cord-267001-csgmc155 258 12 studies study NNS cord-267001-csgmc155 258 13 have have VBP cord-267001-csgmc155 258 14 also also RB cord-267001-csgmc155 258 15 shown show VBN cord-267001-csgmc155 258 16 that that IN cord-267001-csgmc155 258 17 high high JJ cord-267001-csgmc155 258 18 neutralizing neutralize VBG cord-267001-csgmc155 258 19 antibody antibody NN cord-267001-csgmc155 258 20 titer titer NN cord-267001-csgmc155 258 21 may may MD cord-267001-csgmc155 258 22 eliminate eliminate VB cord-267001-csgmc155 258 23 the the DT cord-267001-csgmc155 258 24 potential potential JJ cord-267001-csgmc155 258 25 induction induction NN cord-267001-csgmc155 258 26 of of IN cord-267001-csgmc155 258 27 ADE ADE NNP cord-267001-csgmc155 258 28 [ [ -LRB- cord-267001-csgmc155 258 29 38 38 CD cord-267001-csgmc155 258 30 , , , cord-267001-csgmc155 258 31 39 39 CD cord-267001-csgmc155 258 32 ] ] -RRB- cord-267001-csgmc155 258 33 . . . cord-267001-csgmc155 259 1 [ [ -LRB- cord-267001-csgmc155 259 2 18 18 CD cord-267001-csgmc155 259 3 ] ] -RRB- cord-267001-csgmc155 259 4 [ [ -LRB- cord-267001-csgmc155 259 5 19 19 CD cord-267001-csgmc155 259 6 ] ] -RRB- cord-267001-csgmc155 259 7 [ [ -LRB- cord-267001-csgmc155 259 8 20 20 CD cord-267001-csgmc155 259 9 ] ] -RRB- cord-267001-csgmc155 259 10 40 40 CD cord-267001-csgmc155 259 11 ] ] -RRB- cord-267001-csgmc155 259 12 . . . cord-267001-csgmc155 260 1 In in IN cord-267001-csgmc155 260 2 our -PRON- PRP$ cord-267001-csgmc155 260 3 study study NN cord-267001-csgmc155 260 4 , , , cord-267001-csgmc155 260 5 we -PRON- PRP cord-267001-csgmc155 260 6 show show VBP cord-267001-csgmc155 260 7 immunization immunization NN cord-267001-csgmc155 260 8 of of IN cord-267001-csgmc155 260 9 mice mouse NNS cord-267001-csgmc155 260 10 with with IN cord-267001-csgmc155 260 11 rASP-1 rasp-1 CD cord-267001-csgmc155 260 12 and and CC cord-267001-csgmc155 260 13 the the DT cord-267001-csgmc155 260 14 alum alum NN cord-267001-csgmc155 260 15 - - HYPH cord-267001-csgmc155 260 16 adjuvanted adjuvante VBN cord-267001-csgmc155 260 17 MERS MERS NNP cord-267001-csgmc155 260 18 - - HYPH cord-267001-csgmc155 260 19 CoV CoV NNP cord-267001-csgmc155 260 20 RBD RBD NNP cord-267001-csgmc155 260 21 vaccine vaccine NN cord-267001-csgmc155 260 22 in in IN cord-267001-csgmc155 260 23 separate separate JJ cord-267001-csgmc155 260 24 sites site NNS cord-267001-csgmc155 260 25 have have VBP cord-267001-csgmc155 260 26 induced induce VBN cord-267001-csgmc155 260 27 NT NT NNP cord-267001-csgmc155 260 28 50 50 CD cord-267001-csgmc155 260 29 neutralizing neutralize VBG cord-267001-csgmc155 260 30 antibody antibody NN cord-267001-csgmc155 260 31 titers titer NNS cord-267001-csgmc155 260 32 greater great JJR cord-267001-csgmc155 260 33 than than IN cord-267001-csgmc155 260 34 1:15,000 1:15,000 CD cord-267001-csgmc155 260 35 against against IN cord-267001-csgmc155 260 36 pseudotyped pseudotyped NNP cord-267001-csgmc155 260 37 MERS MERS NNP cord-267001-csgmc155 260 38 - - HYPH cord-267001-csgmc155 260 39 CoV CoV NNP cord-267001-csgmc155 260 40 infection infection NN cord-267001-csgmc155 260 41 . . . cord-267001-csgmc155 261 1 We -PRON- PRP cord-267001-csgmc155 261 2 expect expect VBP cord-267001-csgmc155 261 3 that that IN cord-267001-csgmc155 261 4 such such JJ cord-267001-csgmc155 261 5 high high JJ cord-267001-csgmc155 261 6 - - HYPH cord-267001-csgmc155 261 7 titer titer NN cord-267001-csgmc155 261 8 neutralizing neutralizing NN cord-267001-csgmc155 261 9 may may MD cord-267001-csgmc155 261 10 prevent prevent VB cord-267001-csgmc155 261 11 MERS MERS NNP cord-267001-csgmc155 261 12 - - HYPH cord-267001-csgmc155 261 13 CoV cov NN cord-267001-csgmc155 261 14 infection infection NN cord-267001-csgmc155 261 15 in in IN cord-267001-csgmc155 261 16 vivo vivo NN cord-267001-csgmc155 261 17 without without IN cord-267001-csgmc155 261 18 causing cause VBG cord-267001-csgmc155 261 19 any any DT cord-267001-csgmc155 261 20 adverse adverse JJ cord-267001-csgmc155 261 21 effects effect NNS cord-267001-csgmc155 261 22 . . . cord-267001-csgmc155 262 1 However however RB cord-267001-csgmc155 262 2 , , , cord-267001-csgmc155 262 3 this this DT cord-267001-csgmc155 262 4 will will MD cord-267001-csgmc155 262 5 have have VB cord-267001-csgmc155 262 6 to to TO cord-267001-csgmc155 262 7 be be VB cord-267001-csgmc155 262 8 proven prove VBN cord-267001-csgmc155 262 9 experimentally experimentally RB cord-267001-csgmc155 262 10 in in IN cord-267001-csgmc155 262 11 the the DT cord-267001-csgmc155 262 12 future future NN cord-267001-csgmc155 262 13 . . . cord-267001-csgmc155 263 1 In in IN cord-267001-csgmc155 263 2 this this DT cord-267001-csgmc155 263 3 study study NN cord-267001-csgmc155 263 4 , , , cord-267001-csgmc155 263 5 we -PRON- PRP cord-267001-csgmc155 263 6 also also RB cord-267001-csgmc155 263 7 observed observe VBD cord-267001-csgmc155 263 8 that that IN cord-267001-csgmc155 263 9 immunization immunization NN cord-267001-csgmc155 263 10 with with IN cord-267001-csgmc155 263 11 the the DT cord-267001-csgmc155 263 12 alum alum NN cord-267001-csgmc155 263 13 - - HYPH cord-267001-csgmc155 263 14 adjuvanted adjuvante VBN cord-267001-csgmc155 263 15 RBD RBD NNP cord-267001-csgmc155 263 16 vaccine vaccine NN cord-267001-csgmc155 263 17 elicits elicit VBZ cord-267001-csgmc155 263 18 an an DT cord-267001-csgmc155 263 19 RBD RBD NNP cord-267001-csgmc155 263 20 - - HYPH cord-267001-csgmc155 263 21 specific specific JJ cord-267001-csgmc155 263 22 IgG1-biased igg1-biased JJ cord-267001-csgmc155 263 23 response response NN cord-267001-csgmc155 263 24 , , , cord-267001-csgmc155 263 25 while while IN cord-267001-csgmc155 263 26 the the DT cord-267001-csgmc155 263 27 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 263 28 RBD RBD NNP cord-267001-csgmc155 263 29 vaccine vaccine NN cord-267001-csgmc155 263 30 elicits elicit VBZ cord-267001-csgmc155 263 31 a a DT cord-267001-csgmc155 263 32 balanced balanced JJ cord-267001-csgmc155 263 33 RBD RBD NNP cord-267001-csgmc155 263 34 specific specific JJ cord-267001-csgmc155 263 35 IgG1-IgG2c IgG1-IgG2c NNP cord-267001-csgmc155 263 36 response response NN cord-267001-csgmc155 263 37 ( ( -LRB- cord-267001-csgmc155 263 38 Figure figure NN cord-267001-csgmc155 263 39 S1B s1b NN cord-267001-csgmc155 263 40 , , , cord-267001-csgmc155 263 41 C C NNP cord-267001-csgmc155 263 42 ) ) -RRB- cord-267001-csgmc155 263 43 . . . cord-267001-csgmc155 264 1 Notably notably RB cord-267001-csgmc155 264 2 , , , cord-267001-csgmc155 264 3 in in IN cord-267001-csgmc155 264 4 the the DT cord-267001-csgmc155 264 5 combinatorial combinatorial JJ cord-267001-csgmc155 264 6 adjuvant adjuvant NN cord-267001-csgmc155 264 7 system system NN cord-267001-csgmc155 264 8 where where WRB cord-267001-csgmc155 264 9 rASP-1 rasp-1 NN cord-267001-csgmc155 264 10 and and CC cord-267001-csgmc155 264 11 the the DT cord-267001-csgmc155 264 12 alum alum NN cord-267001-csgmc155 264 13 - - HYPH cord-267001-csgmc155 264 14 adjuvanted adjuvante VBN cord-267001-csgmc155 264 15 RBD RBD NNP cord-267001-csgmc155 264 16 vaccine vaccine NN cord-267001-csgmc155 264 17 are be VBP cord-267001-csgmc155 264 18 co co VBN cord-267001-csgmc155 264 19 - - VBN cord-267001-csgmc155 264 20 administered administer VBN cord-267001-csgmc155 264 21 separately separately RB cord-267001-csgmc155 264 22 the the DT cord-267001-csgmc155 264 23 balanced balanced JJ cord-267001-csgmc155 264 24 IgG1 IgG1 NNP cord-267001-csgmc155 264 25 / / SYM cord-267001-csgmc155 264 26 IgG2c IgG2c NNP cord-267001-csgmc155 264 27 response response NN cord-267001-csgmc155 264 28 ( ( -LRB- cord-267001-csgmc155 264 29 Figure figure NN cord-267001-csgmc155 264 30 S1D s1d NN cord-267001-csgmc155 264 31 ) ) -RRB- cord-267001-csgmc155 264 32 was be VBD cord-267001-csgmc155 264 33 preserved preserve VBN cord-267001-csgmc155 264 34 , , , cord-267001-csgmc155 264 35 while while IN cord-267001-csgmc155 264 36 mice mouse NNS cord-267001-csgmc155 264 37 that that WDT cord-267001-csgmc155 264 38 received receive VBD cord-267001-csgmc155 264 39 the the DT cord-267001-csgmc155 264 40 combinatorial combinatorial JJ cord-267001-csgmc155 264 41 adjuvant adjuvant NN cord-267001-csgmc155 264 42 system system NN cord-267001-csgmc155 264 43 in in IN cord-267001-csgmc155 264 44 a a DT cord-267001-csgmc155 264 45 single single JJ cord-267001-csgmc155 264 46 inoculum inoculum NN cord-267001-csgmc155 264 47 elicited elicit VBD cord-267001-csgmc155 264 48 an an DT cord-267001-csgmc155 264 49 IgG1-biased igg1-biased JJ cord-267001-csgmc155 264 50 response response NN cord-267001-csgmc155 264 51 ( ( -LRB- cord-267001-csgmc155 264 52 Figure figure NN cord-267001-csgmc155 264 53 S1B s1b NN cord-267001-csgmc155 264 54 , , , cord-267001-csgmc155 264 55 D D NNP cord-267001-csgmc155 264 56 ) ) -RRB- cord-267001-csgmc155 264 57 . . . cord-267001-csgmc155 265 1 These these DT cord-267001-csgmc155 265 2 results result NNS cord-267001-csgmc155 265 3 suggest suggest VBP cord-267001-csgmc155 265 4 that that IN cord-267001-csgmc155 265 5 the the DT cord-267001-csgmc155 265 6 presence presence NN cord-267001-csgmc155 265 7 of of IN cord-267001-csgmc155 265 8 rASP-1 rasp-1 NN cord-267001-csgmc155 265 9 in in IN cord-267001-csgmc155 265 10 an an DT cord-267001-csgmc155 265 11 aqueous aqueous JJ cord-267001-csgmc155 265 12 formulation formulation NN cord-267001-csgmc155 265 13 shifts shift VBZ cord-267001-csgmc155 265 14 the the DT cord-267001-csgmc155 265 15 dominant dominant JJ cord-267001-csgmc155 265 16 IgG1 IgG1 NNP cord-267001-csgmc155 265 17 response response NN cord-267001-csgmc155 265 18 elicited elicit VBN cord-267001-csgmc155 265 19 by by IN cord-267001-csgmc155 265 20 the the DT cord-267001-csgmc155 265 21 alum alum NN cord-267001-csgmc155 265 22 - - HYPH cord-267001-csgmc155 265 23 adjuvanted adjuvante VBN cord-267001-csgmc155 265 24 RBD RBD NNP cord-267001-csgmc155 265 25 vaccine vaccine NN cord-267001-csgmc155 265 26 to to IN cord-267001-csgmc155 265 27 a a DT cord-267001-csgmc155 265 28 balanced balanced JJ cord-267001-csgmc155 265 29 IgG1-IgG2c IgG1-IgG2c NNP cord-267001-csgmc155 265 30 response response NN cord-267001-csgmc155 265 31 and and CC cord-267001-csgmc155 266 1 this this DT cord-267001-csgmc155 266 2 was be VBD cord-267001-csgmc155 266 3 more more RBR cord-267001-csgmc155 266 4 pronounced pronounce VBN cord-267001-csgmc155 266 5 when when WRB cord-267001-csgmc155 266 6 rASP-1 rASP-1 NNP cord-267001-csgmc155 266 7 was be VBD cord-267001-csgmc155 266 8 not not RB cord-267001-csgmc155 266 9 adsorbed adsorb VBN cord-267001-csgmc155 266 10 to to IN cord-267001-csgmc155 266 11 alum alum NN cord-267001-csgmc155 266 12 . . . cord-267001-csgmc155 267 1 Interestingly interestingly RB cord-267001-csgmc155 267 2 , , , cord-267001-csgmc155 267 3 the the DT cord-267001-csgmc155 267 4 administration administration NN cord-267001-csgmc155 267 5 of of IN cord-267001-csgmc155 267 6 the the DT cord-267001-csgmc155 267 7 combinatorial combinatorial JJ cord-267001-csgmc155 267 8 adjuvant adjuvant NN cord-267001-csgmc155 267 9 system system NN cord-267001-csgmc155 267 10 showed show VBD cord-267001-csgmc155 267 11 differences difference NNS cord-267001-csgmc155 267 12 in in IN cord-267001-csgmc155 267 13 the the DT cord-267001-csgmc155 267 14 Ly6C Ly6C NNP cord-267001-csgmc155 267 15 + + CC cord-267001-csgmc155 267 16 activated activate VBN cord-267001-csgmc155 267 17 monocyte monocyte NNP cord-267001-csgmc155 267 18 but but CC cord-267001-csgmc155 267 19 not not RB cord-267001-csgmc155 267 20 in in IN cord-267001-csgmc155 267 21 CD11c CD11c NNP cord-267001-csgmc155 267 22 + + CC cord-267001-csgmc155 267 23 activated activate VBN cord-267001-csgmc155 267 24 DC DC NNP cord-267001-csgmc155 267 25 subsets subset NNS cord-267001-csgmc155 267 26 ( ( -LRB- cord-267001-csgmc155 267 27 Figure figure NN cord-267001-csgmc155 267 28 S3 s3 NN cord-267001-csgmc155 267 29 ) ) -RRB- cord-267001-csgmc155 267 30 . . . cord-267001-csgmc155 268 1 This this DT cord-267001-csgmc155 268 2 may may MD cord-267001-csgmc155 268 3 likely likely RB cord-267001-csgmc155 268 4 be be VB cord-267001-csgmc155 268 5 due due JJ cord-267001-csgmc155 268 6 to to IN cord-267001-csgmc155 268 7 the the DT cord-267001-csgmc155 268 8 presence presence NN cord-267001-csgmc155 268 9 of of IN cord-267001-csgmc155 268 10 rASP-1 rASP-1 NNP cord-267001-csgmc155 268 11 in in IN cord-267001-csgmc155 268 12 the the DT cord-267001-csgmc155 268 13 vaccine vaccine NN cord-267001-csgmc155 268 14 , , , cord-267001-csgmc155 268 15 since since IN cord-267001-csgmc155 268 16 we -PRON- PRP cord-267001-csgmc155 268 17 have have VBP cord-267001-csgmc155 268 18 previously previously RB cord-267001-csgmc155 268 19 shown show VBN cord-267001-csgmc155 268 20 that that IN cord-267001-csgmc155 268 21 intra intra JJ cord-267001-csgmc155 268 22 - - JJ cord-267001-csgmc155 268 23 muscular muscular JJ cord-267001-csgmc155 268 24 injection injection NN cord-267001-csgmc155 268 25 rASP-1 rasp-1 NN cord-267001-csgmc155 268 26 alone alone RB cord-267001-csgmc155 268 27 or or CC cord-267001-csgmc155 268 28 the the DT cord-267001-csgmc155 268 29 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 268 30 trivalent trivalent JJ cord-267001-csgmc155 268 31 influenza influenza NN cord-267001-csgmc155 268 32 ( ( -LRB- cord-267001-csgmc155 268 33 IIV3 IIV3 NNP cord-267001-csgmc155 268 34 ) ) -RRB- cord-267001-csgmc155 268 35 vaccine vaccine NN cord-267001-csgmc155 268 36 elicited elicit VBD cord-267001-csgmc155 268 37 an an DT cord-267001-csgmc155 268 38 increased increase VBN cord-267001-csgmc155 268 39 recruitment recruitment NN cord-267001-csgmc155 268 40 of of IN cord-267001-csgmc155 268 41 monocytes monocyte NNS cord-267001-csgmc155 268 42 than than IN cord-267001-csgmc155 268 43 DCs dc NNS cord-267001-csgmc155 268 44 at at IN cord-267001-csgmc155 268 45 the the DT cord-267001-csgmc155 268 46 site site NN cord-267001-csgmc155 268 47 of of IN cord-267001-csgmc155 268 48 injection injection NN cord-267001-csgmc155 268 49 ( ( -LRB- cord-267001-csgmc155 268 50 24 24 CD cord-267001-csgmc155 268 51 h h NN cord-267001-csgmc155 268 52 after after IN cord-267001-csgmc155 268 53 injection injection NN cord-267001-csgmc155 268 54 ) ) -RRB- cord-267001-csgmc155 268 55 as as IN cord-267001-csgmc155 268 56 compared compare VBN cord-267001-csgmc155 268 57 to to IN cord-267001-csgmc155 268 58 PBS PBS NNP cord-267001-csgmc155 268 59 control control NN cord-267001-csgmc155 268 60 group group NN cord-267001-csgmc155 268 61 or or CC cord-267001-csgmc155 268 62 IIV3 IIV3 NNP cord-267001-csgmc155 268 63 alone alone JJ cord-267001-csgmc155 268 64 [ [ -LRB- cord-267001-csgmc155 268 65 12 12 CD cord-267001-csgmc155 268 66 ] ] -RRB- cord-267001-csgmc155 268 67 . . . cord-267001-csgmc155 269 1 In in IN cord-267001-csgmc155 269 2 the the DT cord-267001-csgmc155 269 3 present present JJ cord-267001-csgmc155 269 4 study study NN cord-267001-csgmc155 269 5 , , , cord-267001-csgmc155 269 6 the the DT cord-267001-csgmc155 269 7 administration administration NN cord-267001-csgmc155 269 8 of of IN cord-267001-csgmc155 269 9 the the DT cord-267001-csgmc155 269 10 combinatorial combinatorial JJ cord-267001-csgmc155 269 11 adjuvant adjuvant NN cord-267001-csgmc155 269 12 system system NN cord-267001-csgmc155 269 13 where where WRB cord-267001-csgmc155 269 14 rASP-1 rASP-1 NNP cord-267001-csgmc155 269 15 was be VBD cord-267001-csgmc155 269 16 completely completely RB cord-267001-csgmc155 269 17 adsorbed adsorb VBN cord-267001-csgmc155 269 18 to to IN cord-267001-csgmc155 269 19 alum alum NN cord-267001-csgmc155 269 20 ( ( -LRB- cord-267001-csgmc155 269 21 single single JJ cord-267001-csgmc155 269 22 inoculum inoculum NN cord-267001-csgmc155 269 23 immunization immunization NN cord-267001-csgmc155 269 24 group group NN cord-267001-csgmc155 269 25 ) ) -RRB- cord-267001-csgmc155 269 26 significantly significantly RB cord-267001-csgmc155 269 27 reduced reduce VBD cord-267001-csgmc155 269 28 the the DT cord-267001-csgmc155 269 29 number number NN cord-267001-csgmc155 269 30 of of IN cord-267001-csgmc155 269 31 CD40 CD40 NNP cord-267001-csgmc155 269 32 + + CC cord-267001-csgmc155 269 33 ( ( -LRB- cord-267001-csgmc155 269 34 activated activate VBN cord-267001-csgmc155 269 35 ) ) -RRB- cord-267001-csgmc155 269 36 monocytes monocyte NNS cord-267001-csgmc155 269 37 and and CC cord-267001-csgmc155 269 38 CCR7 CCR7 NNP cord-267001-csgmc155 270 1 + + CC cord-267001-csgmc155 271 1 ( ( -LRB- cord-267001-csgmc155 271 2 migratory migratory JJ cord-267001-csgmc155 271 3 ) ) -RRB- cord-267001-csgmc155 271 4 monocytes monocyte VBZ cord-267001-csgmc155 271 5 to to IN cord-267001-csgmc155 271 6 the the DT cord-267001-csgmc155 271 7 draining drain VBG cord-267001-csgmc155 271 8 LN ln NN cord-267001-csgmc155 271 9 compared compare VBN cord-267001-csgmc155 271 10 to to IN cord-267001-csgmc155 271 11 the the DT cord-267001-csgmc155 271 12 administration administration NN cord-267001-csgmc155 271 13 of of IN cord-267001-csgmc155 271 14 the the DT cord-267001-csgmc155 271 15 combinatorial combinatorial JJ cord-267001-csgmc155 271 16 adjuvant adjuvant NN cord-267001-csgmc155 271 17 system system NN cord-267001-csgmc155 271 18 where where WRB cord-267001-csgmc155 271 19 rASP-1 rASP-1 NNP cord-267001-csgmc155 271 20 was be VBD cord-267001-csgmc155 271 21 not not RB cord-267001-csgmc155 271 22 adsorbed adsorb VBN cord-267001-csgmc155 271 23 to to IN cord-267001-csgmc155 271 24 alum alum NN cord-267001-csgmc155 271 25 ( ( -LRB- cord-267001-csgmc155 271 26 Figure figure NN cord-267001-csgmc155 271 27 3B 3b NN cord-267001-csgmc155 271 28 , , , cord-267001-csgmc155 271 29 C C NNP cord-267001-csgmc155 271 30 ) ) -RRB- cord-267001-csgmc155 271 31 . . . cord-267001-csgmc155 272 1 Interestingly interestingly RB cord-267001-csgmc155 272 2 , , , cord-267001-csgmc155 272 3 the the DT cord-267001-csgmc155 272 4 number number NN cord-267001-csgmc155 272 5 of of IN cord-267001-csgmc155 272 6 CD80 CD80 NNP cord-267001-csgmc155 272 7 + + CC cord-267001-csgmc155 272 8 monocytes monocyte NNS cord-267001-csgmc155 272 9 in in IN cord-267001-csgmc155 272 10 the the DT cord-267001-csgmc155 272 11 LN ln NN cord-267001-csgmc155 272 12 was be VBD cord-267001-csgmc155 272 13 similar similar JJ cord-267001-csgmc155 272 14 whether whether IN cord-267001-csgmc155 272 15 rASP-1 rASP-1 VBN cord-267001-csgmc155 273 1 + + CC cord-267001-csgmc155 274 1 alum alum NN cord-267001-csgmc155 274 2 + + CC cord-267001-csgmc155 274 3 RBD RBD NNP cord-267001-csgmc155 274 4 were be VBD cord-267001-csgmc155 274 5 administered administer VBN cord-267001-csgmc155 274 6 as as IN cord-267001-csgmc155 274 7 a a DT cord-267001-csgmc155 274 8 single single JJ cord-267001-csgmc155 274 9 inoculum inoculum NN cord-267001-csgmc155 274 10 or or CC cord-267001-csgmc155 274 11 as as IN cord-267001-csgmc155 274 12 a a DT cord-267001-csgmc155 274 13 co co NN cord-267001-csgmc155 274 14 - - JJ cord-267001-csgmc155 274 15 administered administer VBN cord-267001-csgmc155 274 16 vaccine vaccine NN cord-267001-csgmc155 274 17 in in IN cord-267001-csgmc155 274 18 two two CD cord-267001-csgmc155 274 19 separate separate JJ cord-267001-csgmc155 274 20 sites site NNS cord-267001-csgmc155 274 21 . . . cord-267001-csgmc155 275 1 However however RB cord-267001-csgmc155 275 2 , , , cord-267001-csgmc155 275 3 both both DT cord-267001-csgmc155 275 4 of of IN cord-267001-csgmc155 275 5 these these DT cord-267001-csgmc155 275 6 vaccine vaccine NN cord-267001-csgmc155 275 7 formulations formulation NNS cord-267001-csgmc155 275 8 as as RB cord-267001-csgmc155 275 9 well well RB cord-267001-csgmc155 275 10 as as IN cord-267001-csgmc155 275 11 the the DT cord-267001-csgmc155 275 12 rASP-1 rASP-1 VBN cord-267001-csgmc155 275 13 adjuvanted adjuvante VBN cord-267001-csgmc155 275 14 - - HYPH cord-267001-csgmc155 275 15 MERS MERS NNP cord-267001-csgmc155 275 16 - - HYPH cord-267001-csgmc155 275 17 RBD RBD NNP cord-267001-csgmc155 275 18 vaccine vaccine NN cord-267001-csgmc155 275 19 resulted result VBD cord-267001-csgmc155 275 20 in in IN cord-267001-csgmc155 275 21 significantly significantly RB cord-267001-csgmc155 275 22 higher high JJR cord-267001-csgmc155 275 23 number number NN cord-267001-csgmc155 275 24 of of IN cord-267001-csgmc155 275 25 recruited recruit VBN cord-267001-csgmc155 275 26 CD80 CD80 NNP cord-267001-csgmc155 275 27 + + CC cord-267001-csgmc155 275 28 monocytes monocyte NNS cord-267001-csgmc155 275 29 than than IN cord-267001-csgmc155 275 30 the the DT cord-267001-csgmc155 275 31 alum alum NN cord-267001-csgmc155 275 32 - - HYPH cord-267001-csgmc155 275 33 adjuvanted adjuvante VBN cord-267001-csgmc155 275 34 RBD RBD NNP cord-267001-csgmc155 275 35 vaccine vaccine NN cord-267001-csgmc155 275 36 , , , cord-267001-csgmc155 275 37 suggesting suggest VBG cord-267001-csgmc155 275 38 that that IN cord-267001-csgmc155 275 39 the the DT cord-267001-csgmc155 275 40 presence presence NN cord-267001-csgmc155 275 41 of of IN cord-267001-csgmc155 275 42 alum alum NN cord-267001-csgmc155 275 43 did do VBD cord-267001-csgmc155 275 44 not not RB cord-267001-csgmc155 275 45 significantly significantly RB cord-267001-csgmc155 275 46 alter alter VB cord-267001-csgmc155 275 47 the the DT cord-267001-csgmc155 275 48 number number NN cord-267001-csgmc155 275 49 of of IN cord-267001-csgmc155 275 50 CD80 CD80 NNP cord-267001-csgmc155 275 51 + + CC cord-267001-csgmc155 275 52 monocytes monocyte NNS cord-267001-csgmc155 275 53 recruited recruit VBN cord-267001-csgmc155 275 54 by by IN cord-267001-csgmc155 275 55 the the DT cord-267001-csgmc155 275 56 combinatorial combinatorial NN cord-267001-csgmc155 275 57 rASP-1 rasp-1 NN cord-267001-csgmc155 275 58 and and CC cord-267001-csgmc155 275 59 alum alum NN cord-267001-csgmc155 275 60 adjuvanted adjuvante VBN cord-267001-csgmc155 275 61 - - HYPH cord-267001-csgmc155 275 62 MERS MERS NNP cord-267001-csgmc155 275 63 - - HYPH cord-267001-csgmc155 275 64 RBD RBD NNP cord-267001-csgmc155 275 65 vaccines vaccine NNS cord-267001-csgmc155 275 66 ( ( -LRB- cord-267001-csgmc155 275 67 Figure figure NN cord-267001-csgmc155 275 68 S3B s3b NN cord-267001-csgmc155 275 69 ) ) -RRB- cord-267001-csgmc155 275 70 . . . cord-267001-csgmc155 276 1 Moreover moreover RB cord-267001-csgmc155 276 2 , , , cord-267001-csgmc155 276 3 there there EX cord-267001-csgmc155 276 4 was be VBD cord-267001-csgmc155 276 5 a a DT cord-267001-csgmc155 276 6 2-fold 2-fold CD cord-267001-csgmc155 276 7 increase increase NN cord-267001-csgmc155 276 8 in in IN cord-267001-csgmc155 276 9 the the DT cord-267001-csgmc155 276 10 number number NN cord-267001-csgmc155 276 11 of of IN cord-267001-csgmc155 276 12 the the DT cord-267001-csgmc155 276 13 activated activate VBN cord-267001-csgmc155 276 14 monocytes monocyte NNS cord-267001-csgmc155 276 15 and and CC cord-267001-csgmc155 276 16 migratory migratory JJ cord-267001-csgmc155 276 17 monocytes monocyte NNS cord-267001-csgmc155 276 18 recruited recruit VBN cord-267001-csgmc155 276 19 to to IN cord-267001-csgmc155 276 20 the the DT cord-267001-csgmc155 276 21 draining drain VBG cord-267001-csgmc155 276 22 LN ln NN cord-267001-csgmc155 276 23 in in IN cord-267001-csgmc155 276 24 mice mouse NNS cord-267001-csgmc155 276 25 that that WDT cord-267001-csgmc155 276 26 received receive VBD cord-267001-csgmc155 276 27 the the DT cord-267001-csgmc155 276 28 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 276 29 RBD RBD NNP cord-267001-csgmc155 276 30 vaccine vaccine NN cord-267001-csgmc155 276 31 when when WRB cord-267001-csgmc155 276 32 compared compare VBN cord-267001-csgmc155 276 33 to to IN cord-267001-csgmc155 276 34 the the DT cord-267001-csgmc155 276 35 alum alum NN cord-267001-csgmc155 276 36 - - HYPH cord-267001-csgmc155 276 37 adjuvanted adjuvante VBN cord-267001-csgmc155 276 38 RBD RBD NNP cord-267001-csgmc155 276 39 vaccine vaccine NN cord-267001-csgmc155 276 40 ( ( -LRB- cord-267001-csgmc155 276 41 Figure figure NN cord-267001-csgmc155 276 42 3B 3b NN cord-267001-csgmc155 276 43 , , , cord-267001-csgmc155 276 44 C C NNP cord-267001-csgmc155 276 45 ) ) -RRB- cord-267001-csgmc155 276 46 . . . cord-267001-csgmc155 277 1 The the DT cord-267001-csgmc155 277 2 number number NN cord-267001-csgmc155 277 3 of of IN cord-267001-csgmc155 277 4 migratory migratory JJ cord-267001-csgmc155 277 5 monocytes monocyte NNS cord-267001-csgmc155 277 6 doubled double VBD cord-267001-csgmc155 277 7 in in IN cord-267001-csgmc155 277 8 the the DT cord-267001-csgmc155 277 9 draining drain VBG cord-267001-csgmc155 277 10 LN ln NN cord-267001-csgmc155 277 11 of of IN cord-267001-csgmc155 277 12 mice mouse NNS cord-267001-csgmc155 277 13 immunized immunize VBN cord-267001-csgmc155 277 14 with with IN cord-267001-csgmc155 277 15 the the DT cord-267001-csgmc155 277 16 combinatorial combinatorial JJ cord-267001-csgmc155 277 17 adjuvant adjuvant NN cord-267001-csgmc155 277 18 system system NN cord-267001-csgmc155 277 19 where where WRB cord-267001-csgmc155 277 20 RBD RBD NNP cord-267001-csgmc155 277 21 + + CC cord-267001-csgmc155 277 22 rASP-1 rasp-1 NN cord-267001-csgmc155 277 23 + + CC cord-267001-csgmc155 277 24 alum alum NN cord-267001-csgmc155 277 25 was be VBD cord-267001-csgmc155 277 26 administered administer VBN cord-267001-csgmc155 277 27 in in IN cord-267001-csgmc155 277 28 a a DT cord-267001-csgmc155 277 29 single single JJ cord-267001-csgmc155 277 30 inoculum inoculum NN cord-267001-csgmc155 277 31 as as IN cord-267001-csgmc155 277 32 compared compare VBN cord-267001-csgmc155 277 33 to to IN cord-267001-csgmc155 277 34 the the DT cord-267001-csgmc155 277 35 alum alum NN cord-267001-csgmc155 277 36 - - HYPH cord-267001-csgmc155 277 37 adjuvanted adjuvante VBN cord-267001-csgmc155 277 38 RBD RBD NNP cord-267001-csgmc155 277 39 vaccine vaccine NN cord-267001-csgmc155 277 40 alone alone RB cord-267001-csgmc155 277 41 . . . cord-267001-csgmc155 278 1 The the DT cord-267001-csgmc155 278 2 number number NN cord-267001-csgmc155 278 3 of of IN cord-267001-csgmc155 278 4 migratory migratory JJ cord-267001-csgmc155 278 5 monocytes monocyte NNS cord-267001-csgmc155 278 6 further further RB cord-267001-csgmc155 278 7 increased increase VBD cord-267001-csgmc155 278 8 in in IN cord-267001-csgmc155 278 9 mice mouse NNS cord-267001-csgmc155 278 10 that that WDT cord-267001-csgmc155 278 11 received receive VBD cord-267001-csgmc155 278 12 the the DT cord-267001-csgmc155 278 13 combinatorial combinatorial JJ cord-267001-csgmc155 278 14 adjuvant adjuvant NN cord-267001-csgmc155 278 15 system system NN cord-267001-csgmc155 278 16 where where WRB cord-267001-csgmc155 278 17 rASP-1 rasp-1 NN cord-267001-csgmc155 278 18 and and CC cord-267001-csgmc155 278 19 the the DT cord-267001-csgmc155 278 20 alum alum NN cord-267001-csgmc155 278 21 - - HYPH cord-267001-csgmc155 278 22 adjuvanted adjuvante VBN cord-267001-csgmc155 278 23 RBD RBD NNP cord-267001-csgmc155 278 24 vaccine vaccine NN cord-267001-csgmc155 278 25 were be VBD cord-267001-csgmc155 278 26 co co VBN cord-267001-csgmc155 278 27 - - VBN cord-267001-csgmc155 278 28 administered administer VBN cord-267001-csgmc155 278 29 separately separately RB cord-267001-csgmc155 278 30 ( ( -LRB- cord-267001-csgmc155 278 31 Figure Figure NNP cord-267001-csgmc155 278 32 3C 3c NN cord-267001-csgmc155 278 33 ) ) -RRB- cord-267001-csgmc155 278 34 . . . cord-267001-csgmc155 279 1 There there EX cord-267001-csgmc155 279 2 were be VBD cord-267001-csgmc155 279 3 no no DT cord-267001-csgmc155 279 4 significant significant JJ cord-267001-csgmc155 279 5 differences difference NNS cord-267001-csgmc155 279 6 observed observe VBN cord-267001-csgmc155 279 7 in in IN cord-267001-csgmc155 279 8 the the DT cord-267001-csgmc155 279 9 number number NN cord-267001-csgmc155 279 10 of of IN cord-267001-csgmc155 279 11 activated activate VBN cord-267001-csgmc155 279 12 and and CC cord-267001-csgmc155 279 13 migratory migratory JJ cord-267001-csgmc155 279 14 DCs dc NNS cord-267001-csgmc155 279 15 across across IN cord-267001-csgmc155 279 16 all all PDT cord-267001-csgmc155 279 17 the the DT cord-267001-csgmc155 279 18 immunization immunization NN cord-267001-csgmc155 279 19 groups group NNS cord-267001-csgmc155 279 20 . . . cord-267001-csgmc155 280 1 Collectively collectively RB cord-267001-csgmc155 280 2 , , , cord-267001-csgmc155 280 3 these these DT cord-267001-csgmc155 280 4 data datum NNS cord-267001-csgmc155 280 5 suggest suggest VBP cord-267001-csgmc155 280 6 that that IN cord-267001-csgmc155 280 7 the the DT cord-267001-csgmc155 280 8 rASP-1 rasp-1 CD cord-267001-csgmc155 280 9 in in IN cord-267001-csgmc155 280 10 the the DT cord-267001-csgmc155 280 11 combinatorial combinatorial JJ cord-267001-csgmc155 280 12 adjuvant adjuvant NN cord-267001-csgmc155 280 13 system system NN cord-267001-csgmc155 280 14 may may MD cord-267001-csgmc155 280 15 play play VB cord-267001-csgmc155 280 16 a a DT cord-267001-csgmc155 280 17 significant significant JJ cord-267001-csgmc155 280 18 role role NN cord-267001-csgmc155 280 19 in in IN cord-267001-csgmc155 280 20 the the DT cord-267001-csgmc155 280 21 enhanced enhanced JJ cord-267001-csgmc155 280 22 recruitment recruitment NN cord-267001-csgmc155 280 23 of of IN cord-267001-csgmc155 280 24 monocyte monocyte NNP cord-267001-csgmc155 280 25 subsets subset NNS cord-267001-csgmc155 280 26 . . . cord-267001-csgmc155 281 1 This this DT cord-267001-csgmc155 281 2 is be VBZ cord-267001-csgmc155 281 3 supported support VBN cord-267001-csgmc155 281 4 with with IN cord-267001-csgmc155 281 5 the the DT cord-267001-csgmc155 281 6 data datum NNS cord-267001-csgmc155 281 7 where where WRB cord-267001-csgmc155 281 8 the the DT cord-267001-csgmc155 281 9 administration administration NN cord-267001-csgmc155 281 10 of of IN cord-267001-csgmc155 281 11 the the DT cord-267001-csgmc155 281 12 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 281 13 RBD RBD NNP cord-267001-csgmc155 281 14 vaccine vaccine NN cord-267001-csgmc155 281 15 also also RB cord-267001-csgmc155 281 16 significantly significantly RB cord-267001-csgmc155 281 17 increased increase VBD cord-267001-csgmc155 281 18 the the DT cord-267001-csgmc155 281 19 number number NN cord-267001-csgmc155 281 20 of of IN cord-267001-csgmc155 281 21 activated activate VBN cord-267001-csgmc155 281 22 ( ( -LRB- cord-267001-csgmc155 281 23 CD40 CD40 NNP cord-267001-csgmc155 281 24 + + SYM cord-267001-csgmc155 281 25 ) ) -RRB- cord-267001-csgmc155 281 26 and and CC cord-267001-csgmc155 281 27 migratory migratory JJ cord-267001-csgmc155 281 28 ( ( -LRB- cord-267001-csgmc155 281 29 CCR7 CCR7 NNP cord-267001-csgmc155 281 30 + + SYM cord-267001-csgmc155 281 31 ) ) -RRB- cord-267001-csgmc155 281 32 monocytes monocyte VBZ cord-267001-csgmc155 281 33 in in IN cord-267001-csgmc155 281 34 the the DT cord-267001-csgmc155 281 35 draining drain VBG cord-267001-csgmc155 281 36 LN ln NN cord-267001-csgmc155 281 37 compared compare VBN cord-267001-csgmc155 281 38 to to IN cord-267001-csgmc155 281 39 alum alum NN cord-267001-csgmc155 281 40 - - HYPH cord-267001-csgmc155 281 41 adjuvanted adjuvante VBN cord-267001-csgmc155 281 42 RBD RBD NNP cord-267001-csgmc155 281 43 vaccine vaccine NN cord-267001-csgmc155 281 44 ( ( -LRB- cord-267001-csgmc155 281 45 Figure figure NN cord-267001-csgmc155 281 46 3B 3b NN cord-267001-csgmc155 281 47 , , , cord-267001-csgmc155 281 48 C C NNP cord-267001-csgmc155 281 49 ) ) -RRB- cord-267001-csgmc155 281 50 . . . cord-267001-csgmc155 282 1 Also also RB cord-267001-csgmc155 282 2 , , , cord-267001-csgmc155 282 3 rASP-1 rasp-1 NN cord-267001-csgmc155 282 4 and and CC cord-267001-csgmc155 282 5 alum alum NN cord-267001-csgmc155 282 6 may may MD cord-267001-csgmc155 282 7 work work VB cord-267001-csgmc155 282 8 in in IN cord-267001-csgmc155 282 9 synergy synergy NN cord-267001-csgmc155 282 10 to to TO cord-267001-csgmc155 282 11 improve improve VB cord-267001-csgmc155 282 12 the the DT cord-267001-csgmc155 282 13 number number NN cord-267001-csgmc155 282 14 of of IN cord-267001-csgmc155 282 15 migratory migratory JJ cord-267001-csgmc155 282 16 monocytes monocyte NNS cord-267001-csgmc155 282 17 in in IN cord-267001-csgmc155 282 18 the the DT cord-267001-csgmc155 282 19 draining drain VBG cord-267001-csgmc155 282 20 LN ln NN cord-267001-csgmc155 282 21 compared compare VBN cord-267001-csgmc155 282 22 to to IN cord-267001-csgmc155 282 23 what what WP cord-267001-csgmc155 282 24 alum alum NN cord-267001-csgmc155 282 25 could could MD cord-267001-csgmc155 282 26 do do VB cord-267001-csgmc155 282 27 alone alone RB cord-267001-csgmc155 282 28 . . . cord-267001-csgmc155 283 1 One one CD cord-267001-csgmc155 283 2 of of IN cord-267001-csgmc155 283 3 the the DT cord-267001-csgmc155 283 4 important important JJ cord-267001-csgmc155 283 5 events event NNS cord-267001-csgmc155 283 6 in in IN cord-267001-csgmc155 283 7 the the DT cord-267001-csgmc155 283 8 generation generation NN cord-267001-csgmc155 283 9 of of IN cord-267001-csgmc155 283 10 an an DT cord-267001-csgmc155 283 11 adaptive adaptive JJ cord-267001-csgmc155 283 12 cellular cellular JJ cord-267001-csgmc155 283 13 response response NN cord-267001-csgmc155 283 14 is be VBZ cord-267001-csgmc155 283 15 the the DT cord-267001-csgmc155 283 16 effective effective JJ cord-267001-csgmc155 283 17 migration migration NN cord-267001-csgmc155 283 18 of of IN cord-267001-csgmc155 283 19 innate innate JJ cord-267001-csgmc155 283 20 cells cell NNS cord-267001-csgmc155 283 21 to to IN cord-267001-csgmc155 283 22 the the DT cord-267001-csgmc155 283 23 lymph lymph NN cord-267001-csgmc155 283 24 nodes node NNS cord-267001-csgmc155 283 25 to to TO cord-267001-csgmc155 283 26 encounter encounter VB cord-267001-csgmc155 283 27 naïve naïve JJ cord-267001-csgmc155 283 28 T t NN cord-267001-csgmc155 283 29 cells cell NNS cord-267001-csgmc155 283 30 , , , cord-267001-csgmc155 283 31 a a DT cord-267001-csgmc155 283 32 process process NN cord-267001-csgmc155 283 33 in in IN cord-267001-csgmc155 283 34 which which WDT cord-267001-csgmc155 283 35 CCR7 CCR7 NNP cord-267001-csgmc155 283 36 , , , cord-267001-csgmc155 283 37 a a DT cord-267001-csgmc155 283 38 chemokine chemokine NN cord-267001-csgmc155 283 39 receptor receptor NN cord-267001-csgmc155 283 40 , , , cord-267001-csgmc155 283 41 is be VBZ cord-267001-csgmc155 283 42 known know VBN cord-267001-csgmc155 283 43 to to TO cord-267001-csgmc155 283 44 play play VB cord-267001-csgmc155 283 45 a a DT cord-267001-csgmc155 283 46 dominant dominant JJ cord-267001-csgmc155 283 47 role role NN cord-267001-csgmc155 283 48 [ [ -LRB- cord-267001-csgmc155 283 49 41 41 CD cord-267001-csgmc155 283 50 ] ] -RRB- cord-267001-csgmc155 283 51 . . . cord-267001-csgmc155 284 1 In in IN cord-267001-csgmc155 284 2 addition addition NN cord-267001-csgmc155 284 3 , , , cord-267001-csgmc155 284 4 the the DT cord-267001-csgmc155 284 5 absence absence NN cord-267001-csgmc155 284 6 of of IN cord-267001-csgmc155 284 7 CCR7 CCR7 NNP cord-267001-csgmc155 284 8 has have VBZ cord-267001-csgmc155 284 9 been be VBN cord-267001-csgmc155 284 10 shown show VBN cord-267001-csgmc155 284 11 to to TO cord-267001-csgmc155 284 12 affect affect VB cord-267001-csgmc155 284 13 the the DT cord-267001-csgmc155 284 14 magnitude magnitude NN cord-267001-csgmc155 284 15 of of IN cord-267001-csgmc155 284 16 protective protective JJ cord-267001-csgmc155 284 17 responses response NNS cord-267001-csgmc155 284 18 against against IN cord-267001-csgmc155 284 19 viral viral JJ cord-267001-csgmc155 284 20 infections infection NNS cord-267001-csgmc155 284 21 in in IN cord-267001-csgmc155 284 22 mouse mouse NN cord-267001-csgmc155 284 23 models model NNS cord-267001-csgmc155 284 24 [ [ -LRB- cord-267001-csgmc155 284 25 42 42 CD cord-267001-csgmc155 284 26 , , , cord-267001-csgmc155 284 27 43 43 CD cord-267001-csgmc155 284 28 ] ] -RRB- cord-267001-csgmc155 284 29 . . . cord-267001-csgmc155 285 1 Therefore therefore RB cord-267001-csgmc155 285 2 , , , cord-267001-csgmc155 285 3 we -PRON- PRP cord-267001-csgmc155 285 4 suggest suggest VBP cord-267001-csgmc155 285 5 that that IN cord-267001-csgmc155 285 6 rASP-1 rasp-1 XX cord-267001-csgmc155 285 7 , , , cord-267001-csgmc155 285 8 when when WRB cord-267001-csgmc155 285 9 not not RB cord-267001-csgmc155 285 10 adsorbed adsorb VBN cord-267001-csgmc155 285 11 to to IN cord-267001-csgmc155 285 12 alum alum NN cord-267001-csgmc155 285 13 in in IN cord-267001-csgmc155 285 14 a a DT cord-267001-csgmc155 285 15 vaccine vaccine NN cord-267001-csgmc155 285 16 formulation formulation NN cord-267001-csgmc155 285 17 , , , cord-267001-csgmc155 285 18 may may MD cord-267001-csgmc155 285 19 improve improve VB cord-267001-csgmc155 285 20 the the DT cord-267001-csgmc155 285 21 effective effective JJ cord-267001-csgmc155 285 22 recruitment recruitment NN cord-267001-csgmc155 285 23 of of IN cord-267001-csgmc155 285 24 innate innate JJ cord-267001-csgmc155 285 25 cells cell NNS cord-267001-csgmc155 285 26 that that WDT cord-267001-csgmc155 285 27 lead lead VBP cord-267001-csgmc155 285 28 to to IN cord-267001-csgmc155 285 29 the the DT cord-267001-csgmc155 285 30 induction induction NN cord-267001-csgmc155 285 31 of of IN cord-267001-csgmc155 285 32 effector effector JJ cord-267001-csgmc155 285 33 adaptive adaptive JJ cord-267001-csgmc155 285 34 cellular cellular JJ cord-267001-csgmc155 285 35 responses response NNS cord-267001-csgmc155 285 36 . . . cord-267001-csgmc155 286 1 TfH tfh NN cord-267001-csgmc155 286 2 cells cell NNS cord-267001-csgmc155 286 3 can can MD cord-267001-csgmc155 286 4 determine determine VB cord-267001-csgmc155 286 5 humoral humoral JJ cord-267001-csgmc155 286 6 immunity immunity NN cord-267001-csgmc155 286 7 that that WDT cord-267001-csgmc155 286 8 is be VBZ cord-267001-csgmc155 286 9 also also RB cord-267001-csgmc155 286 10 derived derive VBN cord-267001-csgmc155 286 11 from from IN cord-267001-csgmc155 286 12 GC GC NNP cord-267001-csgmc155 286 13 B B NNP cord-267001-csgmc155 286 14 cells cell NNS cord-267001-csgmc155 286 15 , , , cord-267001-csgmc155 286 16 and and CC cord-267001-csgmc155 286 17 therefore therefore RB cord-267001-csgmc155 286 18 both both DT cord-267001-csgmc155 286 19 of of IN cord-267001-csgmc155 286 20 these these DT cord-267001-csgmc155 286 21 cell cell NN cord-267001-csgmc155 286 22 types type NNS cord-267001-csgmc155 286 23 have have VBP cord-267001-csgmc155 286 24 become become VBN cord-267001-csgmc155 286 25 an an DT cord-267001-csgmc155 286 26 important important JJ cord-267001-csgmc155 286 27 aspect aspect NN cord-267001-csgmc155 286 28 for for IN cord-267001-csgmc155 286 29 rational rational JJ cord-267001-csgmc155 286 30 designs design NNS cord-267001-csgmc155 286 31 of of IN cord-267001-csgmc155 286 32 more more JJR cord-267001-csgmc155 286 33 effective effective JJ cord-267001-csgmc155 286 34 vaccines vaccine NNS cord-267001-csgmc155 286 35 , , , cord-267001-csgmc155 286 36 in in IN cord-267001-csgmc155 286 37 particular particular JJ cord-267001-csgmc155 286 38 those those DT cord-267001-csgmc155 286 39 depending depend VBG cord-267001-csgmc155 286 40 on on IN cord-267001-csgmc155 286 41 functional functional JJ cord-267001-csgmc155 286 42 antibodies antibody NNS cord-267001-csgmc155 286 43 for for IN cord-267001-csgmc155 286 44 their -PRON- PRP$ cord-267001-csgmc155 286 45 efficacy efficacy NN cord-267001-csgmc155 286 46 [ [ -LRB- cord-267001-csgmc155 286 47 44 44 CD cord-267001-csgmc155 286 48 , , , cord-267001-csgmc155 286 49 45 45 CD cord-267001-csgmc155 286 50 ] ] -RRB- cord-267001-csgmc155 286 51 . . . cord-267001-csgmc155 287 1 To to TO cord-267001-csgmc155 287 2 better better RB cord-267001-csgmc155 287 3 understand understand VB cord-267001-csgmc155 287 4 what what WP cord-267001-csgmc155 287 5 contributed contribute VBD cord-267001-csgmc155 287 6 to to IN cord-267001-csgmc155 287 7 the the DT cord-267001-csgmc155 287 8 improved improved JJ cord-267001-csgmc155 287 9 elicitation elicitation NN cord-267001-csgmc155 287 10 of of IN cord-267001-csgmc155 287 11 functional functional JJ cord-267001-csgmc155 287 12 anti anti JJ cord-267001-csgmc155 287 13 - - JJ cord-267001-csgmc155 287 14 MERS mers JJ cord-267001-csgmc155 287 15 - - HYPH cord-267001-csgmc155 287 16 CoV CoV NNP cord-267001-csgmc155 287 17 neutralizing neutralize VBG cord-267001-csgmc155 287 18 antibodies antibody NNS cord-267001-csgmc155 287 19 , , , cord-267001-csgmc155 287 20 the the DT cord-267001-csgmc155 287 21 frequencies frequency NNS cord-267001-csgmc155 287 22 of of IN cord-267001-csgmc155 287 23 TfH tfh NN cord-267001-csgmc155 287 24 ( ( -LRB- cord-267001-csgmc155 287 25 CD4 CD4 NNP cord-267001-csgmc155 287 26 + + CC cord-267001-csgmc155 287 27 CXCR5 cxcr5 XX cord-267001-csgmc155 288 1 + + CC cord-267001-csgmc155 288 2 PD-1 PD-1 NNP cord-267001-csgmc155 288 3 + + JJ cord-267001-csgmc155 288 4 ) ) -RRB- cord-267001-csgmc155 288 5 cells cell NNS cord-267001-csgmc155 288 6 and and CC cord-267001-csgmc155 288 7 GC GC NNP cord-267001-csgmc155 288 8 B B NNP cord-267001-csgmc155 288 9 ( ( -LRB- cord-267001-csgmc155 288 10 B220 b220 RB cord-267001-csgmc155 288 11 + + SYM cord-267001-csgmc155 288 12 CD95 CD95 NNP cord-267001-csgmc155 288 13 + + -RRB- cord-267001-csgmc155 289 1 GL-7 GL-7 NNP cord-267001-csgmc155 289 2 + + CC cord-267001-csgmc155 289 3 ) ) -RRB- cord-267001-csgmc155 289 4 cells cell NNS cord-267001-csgmc155 289 5 in in IN cord-267001-csgmc155 289 6 the the DT cord-267001-csgmc155 289 7 draining drain VBG cord-267001-csgmc155 289 8 LN ln NN cord-267001-csgmc155 289 9 of of IN cord-267001-csgmc155 289 10 immunized immunize VBN cord-267001-csgmc155 289 11 mice mouse NNS cord-267001-csgmc155 289 12 were be VBD cord-267001-csgmc155 289 13 analyzed analyze VBN cord-267001-csgmc155 289 14 . . . cord-267001-csgmc155 290 1 A a DT cord-267001-csgmc155 290 2 two two CD cord-267001-csgmc155 290 3 - - HYPH cord-267001-csgmc155 290 4 fold fold JJ cord-267001-csgmc155 290 5 increase increase NN cord-267001-csgmc155 290 6 in in IN cord-267001-csgmc155 290 7 both both DT cord-267001-csgmc155 290 8 TfH tfh NN cord-267001-csgmc155 290 9 and and CC cord-267001-csgmc155 290 10 GC GC NNP cord-267001-csgmc155 290 11 B B NNP cord-267001-csgmc155 290 12 frequencies frequency NNS cord-267001-csgmc155 290 13 were be VBD cord-267001-csgmc155 290 14 induced induce VBN cord-267001-csgmc155 290 15 when when WRB cord-267001-csgmc155 290 16 rASP-1 rASP-1 JJS cord-267001-csgmc155 290 17 and and CC cord-267001-csgmc155 290 18 the the DT cord-267001-csgmc155 290 19 alum alum NN cord-267001-csgmc155 290 20 - - HYPH cord-267001-csgmc155 290 21 adjuvanted adjuvante VBN cord-267001-csgmc155 290 22 RBD RBD NNP cord-267001-csgmc155 290 23 vaccine vaccine NN cord-267001-csgmc155 290 24 were be VBD cord-267001-csgmc155 290 25 co co VBN cord-267001-csgmc155 290 26 - - VBN cord-267001-csgmc155 290 27 administered administer VBN cord-267001-csgmc155 290 28 in in IN cord-267001-csgmc155 290 29 separate separate JJ cord-267001-csgmc155 290 30 sites site NNS cord-267001-csgmc155 290 31 as as IN cord-267001-csgmc155 290 32 compared compare VBN cord-267001-csgmc155 290 33 to to IN cord-267001-csgmc155 290 34 the the DT cord-267001-csgmc155 290 35 combinatorial combinatorial JJ cord-267001-csgmc155 290 36 adjuvant adjuvant NN cord-267001-csgmc155 290 37 system system NN cord-267001-csgmc155 290 38 where where WRB cord-267001-csgmc155 290 39 RBD RBD NNP cord-267001-csgmc155 290 40 + + CC cord-267001-csgmc155 290 41 rASP-1 rasp-1 NN cord-267001-csgmc155 290 42 + + CC cord-267001-csgmc155 290 43 alum alum NN cord-267001-csgmc155 290 44 were be VBD cord-267001-csgmc155 290 45 administered administer VBN cord-267001-csgmc155 290 46 in in IN cord-267001-csgmc155 290 47 a a DT cord-267001-csgmc155 290 48 single single JJ cord-267001-csgmc155 290 49 inoculum inoculum NN cord-267001-csgmc155 290 50 ( ( -LRB- cord-267001-csgmc155 290 51 Figures figure NNS cord-267001-csgmc155 290 52 4B 4b NN cord-267001-csgmc155 290 53 and and CC cord-267001-csgmc155 290 54 5C 5c CD cord-267001-csgmc155 290 55 ) ) -RRB- cord-267001-csgmc155 290 56 . . . cord-267001-csgmc155 291 1 While while IN cord-267001-csgmc155 291 2 no no DT cord-267001-csgmc155 291 3 significant significant JJ cord-267001-csgmc155 291 4 difference difference NN cord-267001-csgmc155 291 5 was be VBD cord-267001-csgmc155 291 6 observed observe VBN cord-267001-csgmc155 291 7 in in IN cord-267001-csgmc155 291 8 the the DT cord-267001-csgmc155 291 9 fold fold JJ cord-267001-csgmc155 291 10 increase increase NN cord-267001-csgmc155 291 11 of of IN cord-267001-csgmc155 291 12 the the DT cord-267001-csgmc155 291 13 frequency frequency NN cord-267001-csgmc155 291 14 of of IN cord-267001-csgmc155 291 15 GC GC NNP cord-267001-csgmc155 291 16 B B NNP cord-267001-csgmc155 291 17 cells cell NNS cord-267001-csgmc155 291 18 in in IN cord-267001-csgmc155 291 19 the the DT cord-267001-csgmc155 291 20 LN ln NN cord-267001-csgmc155 291 21 of of IN cord-267001-csgmc155 291 22 mice mouse NNS cord-267001-csgmc155 291 23 that that WDT cord-267001-csgmc155 291 24 were be VBD cord-267001-csgmc155 291 25 immunized immunize VBN cord-267001-csgmc155 291 26 with with IN cord-267001-csgmc155 291 27 rASP-1 rASP-1 NNP cord-267001-csgmc155 291 28 and and CC cord-267001-csgmc155 291 29 the the DT cord-267001-csgmc155 291 30 alum alum NN cord-267001-csgmc155 291 31 - - HYPH cord-267001-csgmc155 291 32 adjuvanted adjuvante VBN cord-267001-csgmc155 291 33 RBD RBD NNP cord-267001-csgmc155 291 34 vaccine vaccine NN cord-267001-csgmc155 291 35 co co VBD cord-267001-csgmc155 291 36 - - VBN cord-267001-csgmc155 291 37 administered administer VBN cord-267001-csgmc155 291 38 separately separately RB cord-267001-csgmc155 291 39 as as IN cord-267001-csgmc155 291 40 compared compare VBN cord-267001-csgmc155 291 41 to to IN cord-267001-csgmc155 291 42 the the DT cord-267001-csgmc155 291 43 alum alum NN cord-267001-csgmc155 291 44 - - HYPH cord-267001-csgmc155 291 45 adjuvanted adjuvante VBN cord-267001-csgmc155 291 46 RBD RBD NNP cord-267001-csgmc155 291 47 vaccine vaccine NN cord-267001-csgmc155 291 48 , , , cord-267001-csgmc155 291 49 a a DT cord-267001-csgmc155 291 50 six six CD cord-267001-csgmc155 291 51 - - RB cord-267001-csgmc155 291 52 fold fold JJ cord-267001-csgmc155 291 53 increase increase NN cord-267001-csgmc155 291 54 was be VBD cord-267001-csgmc155 291 55 observed observe VBN cord-267001-csgmc155 291 56 when when WRB cord-267001-csgmc155 291 57 this this DT cord-267001-csgmc155 291 58 was be VBD cord-267001-csgmc155 291 59 compared compare VBN cord-267001-csgmc155 291 60 to to IN cord-267001-csgmc155 291 61 rASP-1-adjuvanted rasp-1-adjuvante VBN cord-267001-csgmc155 291 62 RBD RBD NNP cord-267001-csgmc155 291 63 vaccine vaccine NN cord-267001-csgmc155 291 64 alone alone JJ cord-267001-csgmc155 291 65 ( ( -LRB- cord-267001-csgmc155 291 66 Figure figure NN cord-267001-csgmc155 291 67 5C 5c CD cord-267001-csgmc155 291 68 ) ) -RRB- cord-267001-csgmc155 291 69 . . . cord-267001-csgmc155 292 1 These these DT cord-267001-csgmc155 292 2 data datum NNS cord-267001-csgmc155 292 3 suggest suggest VBP cord-267001-csgmc155 292 4 that that IN cord-267001-csgmc155 292 5 the the DT cord-267001-csgmc155 292 6 complete complete JJ cord-267001-csgmc155 292 7 adsorption adsorption NN cord-267001-csgmc155 292 8 of of IN cord-267001-csgmc155 292 9 rASP-1 rasp-1 NN cord-267001-csgmc155 292 10 to to IN cord-267001-csgmc155 292 11 alum alum NN cord-267001-csgmc155 292 12 diminished diminish VBD cord-267001-csgmc155 292 13 not not RB cord-267001-csgmc155 292 14 only only RB cord-267001-csgmc155 292 15 the the DT cord-267001-csgmc155 292 16 ability ability NN cord-267001-csgmc155 292 17 to to TO cord-267001-csgmc155 292 18 induce induce VB cord-267001-csgmc155 292 19 migratory migratory JJ cord-267001-csgmc155 292 20 monocyte monocyte NNP cord-267001-csgmc155 292 21 , , , cord-267001-csgmc155 292 22 but but CC cord-267001-csgmc155 292 23 also also RB cord-267001-csgmc155 292 24 the the DT cord-267001-csgmc155 292 25 development development NN cord-267001-csgmc155 292 26 of of IN cord-267001-csgmc155 292 27 cells cell NNS cord-267001-csgmc155 292 28 that that WDT cord-267001-csgmc155 292 29 are be VBP cord-267001-csgmc155 292 30 important important JJ cord-267001-csgmc155 292 31 for for IN cord-267001-csgmc155 292 32 mounting mount VBG cord-267001-csgmc155 292 33 an an DT cord-267001-csgmc155 292 34 effective effective JJ cord-267001-csgmc155 292 35 humoral humoral JJ cord-267001-csgmc155 292 36 response response NN cord-267001-csgmc155 292 37 . . . cord-267001-csgmc155 293 1 Importantly importantly RB cord-267001-csgmc155 293 2 , , , cord-267001-csgmc155 293 3 we -PRON- PRP cord-267001-csgmc155 293 4 found find VBD cord-267001-csgmc155 293 5 a a DT cord-267001-csgmc155 293 6 significant significant JJ cord-267001-csgmc155 293 7 and and CC cord-267001-csgmc155 293 8 positive positive JJ cord-267001-csgmc155 293 9 correlation correlation NN cord-267001-csgmc155 293 10 between between IN cord-267001-csgmc155 293 11 the the DT cord-267001-csgmc155 293 12 neutralizing neutralize VBG cord-267001-csgmc155 293 13 antibody antibody NN cord-267001-csgmc155 293 14 titers titer NNS cord-267001-csgmc155 293 15 in in IN cord-267001-csgmc155 293 16 sera sera NNP cord-267001-csgmc155 293 17 of of IN cord-267001-csgmc155 293 18 mice mouse NNS cord-267001-csgmc155 293 19 vaccinated vaccinate VBN cord-267001-csgmc155 293 20 with with IN cord-267001-csgmc155 293 21 rASP-1 rASP-1 NNP cord-267001-csgmc155 293 22 and and CC cord-267001-csgmc155 293 23 the the DT cord-267001-csgmc155 293 24 alum alum NN cord-267001-csgmc155 293 25 adjuvanted adjuvante VBD cord-267001-csgmc155 293 26 RBD RBD NNP cord-267001-csgmc155 293 27 vaccine vaccine NN cord-267001-csgmc155 293 28 separately separately RB cord-267001-csgmc155 293 29 and and CC cord-267001-csgmc155 293 30 the the DT cord-267001-csgmc155 293 31 fold fold JJ cord-267001-csgmc155 293 32 increase increase NN cord-267001-csgmc155 293 33 in in IN cord-267001-csgmc155 293 34 the the DT cord-267001-csgmc155 293 35 frequency frequency NN cord-267001-csgmc155 293 36 of of IN cord-267001-csgmc155 293 37 TfH tfh NN cord-267001-csgmc155 293 38 and and CC cord-267001-csgmc155 293 39 GC GC NNP cord-267001-csgmc155 293 40 B B NNP cord-267001-csgmc155 293 41 cells cell NNS cord-267001-csgmc155 293 42 recruited recruit VBN cord-267001-csgmc155 293 43 in in IN cord-267001-csgmc155 293 44 the the DT cord-267001-csgmc155 293 45 draining drain VBG cord-267001-csgmc155 293 46 LN ln NN cord-267001-csgmc155 293 47 ( ( -LRB- cord-267001-csgmc155 293 48 Figures figure NNS cord-267001-csgmc155 293 49 4C 4c CD cord-267001-csgmc155 293 50 and and CC cord-267001-csgmc155 293 51 5D 5D NNP cord-267001-csgmc155 293 52 ) ) -RRB- cord-267001-csgmc155 293 53 . . . cord-267001-csgmc155 294 1 Interestingly interestingly RB cord-267001-csgmc155 294 2 , , , cord-267001-csgmc155 294 3 the the DT cord-267001-csgmc155 294 4 fold fold JJ cord-267001-csgmc155 294 5 increase increase NN cord-267001-csgmc155 294 6 in in IN cord-267001-csgmc155 294 7 the the DT cord-267001-csgmc155 294 8 frequency frequency NN cord-267001-csgmc155 294 9 of of IN cord-267001-csgmc155 294 10 TfH tfh NN cord-267001-csgmc155 294 11 cells cell NNS cord-267001-csgmc155 294 12 was be VBD cord-267001-csgmc155 294 13 also also RB cord-267001-csgmc155 294 14 significantly significantly RB cord-267001-csgmc155 294 15 and and CC cord-267001-csgmc155 294 16 positively positively RB cord-267001-csgmc155 294 17 associated associate VBN cord-267001-csgmc155 294 18 with with IN cord-267001-csgmc155 294 19 the the DT cord-267001-csgmc155 294 20 titers titer NNS cord-267001-csgmc155 294 21 of of IN cord-267001-csgmc155 294 22 neutralizing neutralize VBG cord-267001-csgmc155 294 23 antibodies antibody NNS cord-267001-csgmc155 294 24 in in IN cord-267001-csgmc155 294 25 mice mouse NNS cord-267001-csgmc155 294 26 that that WDT cord-267001-csgmc155 294 27 were be VBD cord-267001-csgmc155 294 28 immunized immunize VBN cord-267001-csgmc155 294 29 with with IN cord-267001-csgmc155 294 30 the the DT cord-267001-csgmc155 294 31 combinatorial combinatorial JJ cord-267001-csgmc155 294 32 adjuvant adjuvant NN cord-267001-csgmc155 294 33 system system NN cord-267001-csgmc155 294 34 administered administer VBN cord-267001-csgmc155 294 35 in in IN cord-267001-csgmc155 294 36 a a DT cord-267001-csgmc155 294 37 single single JJ cord-267001-csgmc155 294 38 inoculum inoculum NN cord-267001-csgmc155 294 39 ( ( -LRB- cord-267001-csgmc155 294 40 RBD RBD NNP cord-267001-csgmc155 294 41 + + CC cord-267001-csgmc155 294 42 rASP-1 rasp-1 NN cord-267001-csgmc155 294 43 + + CC cord-267001-csgmc155 294 44 alum alum NN cord-267001-csgmc155 294 45 ; ; : cord-267001-csgmc155 294 46 Figure figure NN cord-267001-csgmc155 294 47 4B 4b CD cord-267001-csgmc155 294 48 ) ) -RRB- cord-267001-csgmc155 294 49 , , , cord-267001-csgmc155 294 50 suggesting suggest VBG cord-267001-csgmc155 294 51 that that IN cord-267001-csgmc155 294 52 the the DT cord-267001-csgmc155 294 53 rASP-1 rasp-1 NN cord-267001-csgmc155 294 54 and and CC cord-267001-csgmc155 294 55 alum alum NN cord-267001-csgmc155 294 56 may may MD cord-267001-csgmc155 294 57 work work VB cord-267001-csgmc155 294 58 in in IN cord-267001-csgmc155 294 59 synergy synergy NN cord-267001-csgmc155 294 60 . . . cord-267001-csgmc155 295 1 Our -PRON- PRP$ cord-267001-csgmc155 295 2 study study NN cord-267001-csgmc155 295 3 demonstrates demonstrate VBZ cord-267001-csgmc155 295 4 that that IN cord-267001-csgmc155 295 5 a a DT cord-267001-csgmc155 295 6 unique unique JJ cord-267001-csgmc155 295 7 combination combination NN cord-267001-csgmc155 295 8 of of IN cord-267001-csgmc155 295 9 rASP-1 rasp-1 NN cord-267001-csgmc155 295 10 ( ( -LRB- cord-267001-csgmc155 295 11 a a DT cord-267001-csgmc155 295 12 helminth helminth NN cord-267001-csgmc155 295 13 - - HYPH cord-267001-csgmc155 295 14 derived derive VBN cord-267001-csgmc155 295 15 protein protein NN cord-267001-csgmc155 295 16 ) ) -RRB- cord-267001-csgmc155 295 17 protein protein NN cord-267001-csgmc155 295 18 adjuvant adjuvant NN cord-267001-csgmc155 295 19 with with IN cord-267001-csgmc155 295 20 alum alum NN cord-267001-csgmc155 295 21 and and CC cord-267001-csgmc155 295 22 the the DT cord-267001-csgmc155 295 23 MERS MERS NNP cord-267001-csgmc155 295 24 - - HYPH cord-267001-csgmc155 295 25 RBD RBD NNP cord-267001-csgmc155 295 26 - - HYPH cord-267001-csgmc155 295 27 Fd Fd NNP cord-267001-csgmc155 295 28 using use VBG cord-267001-csgmc155 295 29 the the DT cord-267001-csgmc155 295 30 model model NN cord-267001-csgmc155 295 31 vaccine vaccine NN cord-267001-csgmc155 295 32 antigen antigen NN cord-267001-csgmc155 295 33 enhanced enhance VBD cord-267001-csgmc155 295 34 the the DT cord-267001-csgmc155 295 35 protective protective JJ cord-267001-csgmc155 295 36 immune immune JJ cord-267001-csgmc155 295 37 responses response NNS cord-267001-csgmc155 295 38 to to IN cord-267001-csgmc155 295 39 MERS MERS NNP cord-267001-csgmc155 295 40 - - HYPH cord-267001-csgmc155 295 41 CoV CoV NNP cord-267001-csgmc155 295 42 , , , cord-267001-csgmc155 295 43 despite despite IN cord-267001-csgmc155 295 44 the the DT cord-267001-csgmc155 295 45 fact fact NN cord-267001-csgmc155 295 46 that that IN cord-267001-csgmc155 295 47 adjuvants adjuvant NNS cord-267001-csgmc155 295 48 have have VBP cord-267001-csgmc155 295 49 to to TO cord-267001-csgmc155 295 50 be be VB cord-267001-csgmc155 295 51 co co VBN cord-267001-csgmc155 295 52 - - VBN cord-267001-csgmc155 295 53 administered administer VBN cord-267001-csgmc155 295 54 separately separately RB cord-267001-csgmc155 295 55 ( ( -LRB- cord-267001-csgmc155 295 56 where where WRB cord-267001-csgmc155 295 57 rASP-1 rASP-1 NNP cord-267001-csgmc155 295 58 was be VBD cord-267001-csgmc155 295 59 not not RB cord-267001-csgmc155 295 60 adsorbed adsorb VBN cord-267001-csgmc155 295 61 to to IN cord-267001-csgmc155 295 62 alum alum NN cord-267001-csgmc155 295 63 ) ) -RRB- cord-267001-csgmc155 295 64 . . . cord-267001-csgmc155 296 1 Also also RB cord-267001-csgmc155 296 2 , , , cord-267001-csgmc155 296 3 for for IN cord-267001-csgmc155 296 4 the the DT cord-267001-csgmc155 296 5 first first JJ cord-267001-csgmc155 296 6 time time NN cord-267001-csgmc155 296 7 , , , cord-267001-csgmc155 296 8 we -PRON- PRP cord-267001-csgmc155 296 9 were be VBD cord-267001-csgmc155 296 10 able able JJ cord-267001-csgmc155 296 11 to to TO cord-267001-csgmc155 296 12 determine determine VB cord-267001-csgmc155 296 13 that that IN cord-267001-csgmc155 296 14 the the DT cord-267001-csgmc155 296 15 TfH tfh NN cord-267001-csgmc155 296 16 and and CC cord-267001-csgmc155 296 17 GC GC NNP cord-267001-csgmc155 296 18 B B NNP cord-267001-csgmc155 296 19 cells cell NNS cord-267001-csgmc155 296 20 in in IN cord-267001-csgmc155 296 21 the the DT cord-267001-csgmc155 296 22 LNs ln NNS cord-267001-csgmc155 296 23 in in IN cord-267001-csgmc155 296 24 mice mouse NNS cord-267001-csgmc155 296 25 immunized immunize VBN cord-267001-csgmc155 296 26 with with IN cord-267001-csgmc155 296 27 combinatorial combinatorial JJ cord-267001-csgmc155 296 28 adjuvanted adjuvante VBN cord-267001-csgmc155 296 29 - - HYPH cord-267001-csgmc155 296 30 MERS MERS NNP cord-267001-csgmc155 296 31 - - HYPH cord-267001-csgmc155 296 32 RBD RBD NNP cord-267001-csgmc155 296 33 vaccine vaccine NN cord-267001-csgmc155 296 34 were be VBD cord-267001-csgmc155 296 35 significantly significantly RB cord-267001-csgmc155 296 36 and and CC cord-267001-csgmc155 296 37 positively positively RB cord-267001-csgmc155 296 38 associated associate VBN cord-267001-csgmc155 296 39 with with IN cord-267001-csgmc155 296 40 the the DT cord-267001-csgmc155 296 41 essential essential JJ cord-267001-csgmc155 296 42 functional functional JJ cord-267001-csgmc155 296 43 protective protective JJ cord-267001-csgmc155 296 44 immune immune JJ cord-267001-csgmc155 296 45 responses response NNS cord-267001-csgmc155 296 46 to to IN cord-267001-csgmc155 296 47 MERS MERS NNP cord-267001-csgmc155 296 48 - - HYPH cord-267001-csgmc155 296 49 CoV CoV NNP cord-267001-csgmc155 296 50 neutralizing neutralize VBG cord-267001-csgmc155 296 51 antibodies antibody NNS cord-267001-csgmc155 296 52 . . . cord-267001-csgmc155 297 1 Further further JJ cord-267001-csgmc155 297 2 studies study NNS cord-267001-csgmc155 297 3 will will MD cord-267001-csgmc155 297 4 be be VB cord-267001-csgmc155 297 5 necessary necessary JJ cord-267001-csgmc155 297 6 , , , cord-267001-csgmc155 297 7 however however RB cord-267001-csgmc155 297 8 , , , cord-267001-csgmc155 297 9 to to TO cord-267001-csgmc155 297 10 elucidate elucidate VB cord-267001-csgmc155 297 11 the the DT cord-267001-csgmc155 297 12 precise precise JJ cord-267001-csgmc155 297 13 underlining underlining NN cord-267001-csgmc155 297 14 mechanisms mechanism NNS cord-267001-csgmc155 297 15 of of IN cord-267001-csgmc155 297 16 this this DT cord-267001-csgmc155 297 17 unique unique JJ cord-267001-csgmc155 297 18 adjuvant adjuvant JJ cord-267001-csgmc155 297 19 combination combination NN cord-267001-csgmc155 297 20 of of IN cord-267001-csgmc155 297 21 rASP-1 rasp-1 NN cord-267001-csgmc155 297 22 and and CC cord-267001-csgmc155 297 23 alum alum NN cord-267001-csgmc155 297 24 . . . cord-267001-csgmc155 298 1 In in IN cord-267001-csgmc155 298 2 our -PRON- PRP$ cord-267001-csgmc155 298 3 study study NN cord-267001-csgmc155 298 4 , , , cord-267001-csgmc155 298 5 it -PRON- PRP cord-267001-csgmc155 298 6 appeared appear VBD cord-267001-csgmc155 298 7 that that IN cord-267001-csgmc155 298 8 the the DT cord-267001-csgmc155 298 9 adsorption adsorption NN cord-267001-csgmc155 298 10 of of IN cord-267001-csgmc155 298 11 rASP-1 rASP-1 NNP cord-267001-csgmc155 298 12 to to IN cord-267001-csgmc155 298 13 alum alum NN cord-267001-csgmc155 298 14 reduced reduce VBD cord-267001-csgmc155 298 15 the the DT cord-267001-csgmc155 298 16 immunopotentiating immunopotentiating NN cord-267001-csgmc155 298 17 activities activity NNS cord-267001-csgmc155 298 18 of of IN cord-267001-csgmc155 298 19 either either CC cord-267001-csgmc155 298 20 rASP-1 rasp-1 NN cord-267001-csgmc155 298 21 or or CC cord-267001-csgmc155 298 22 alum alum NN cord-267001-csgmc155 298 23 . . . cord-267001-csgmc155 299 1 As as IN cord-267001-csgmc155 299 2 the the DT cord-267001-csgmc155 299 3 potency potency NN cord-267001-csgmc155 299 4 of of IN cord-267001-csgmc155 299 5 rASP-1 rasp-1 NN cord-267001-csgmc155 299 6 is be VBZ cord-267001-csgmc155 299 7 highest high JJS cord-267001-csgmc155 299 8 when when WRB cord-267001-csgmc155 299 9 it -PRON- PRP cord-267001-csgmc155 299 10 is be VBZ cord-267001-csgmc155 299 11 in in IN cord-267001-csgmc155 299 12 an an DT cord-267001-csgmc155 299 13 aqueous aqueous JJ cord-267001-csgmc155 299 14 formulation formulation NN cord-267001-csgmc155 299 15 , , , cord-267001-csgmc155 299 16 a a DT cord-267001-csgmc155 299 17 better well JJR cord-267001-csgmc155 299 18 understanding understanding NN cord-267001-csgmc155 299 19 of of IN cord-267001-csgmc155 299 20 the the DT cord-267001-csgmc155 299 21 targets target NNS cord-267001-csgmc155 299 22 of of IN cord-267001-csgmc155 299 23 multiple multiple JJ cord-267001-csgmc155 299 24 immune immune JJ cord-267001-csgmc155 299 25 pathways pathway NNS cord-267001-csgmc155 299 26 that that WDT cord-267001-csgmc155 299 27 are be VBP cord-267001-csgmc155 299 28 induced induce VBN cord-267001-csgmc155 299 29 may may MD cord-267001-csgmc155 299 30 also also RB cord-267001-csgmc155 299 31 help help VB cord-267001-csgmc155 299 32 us -PRON- PRP cord-267001-csgmc155 299 33 utilize utilize VB cord-267001-csgmc155 299 34 the the DT cord-267001-csgmc155 299 35 rASP-1 rASP-1 NNP cord-267001-csgmc155 299 36 protein protein NN cord-267001-csgmc155 299 37 adjuvant adjuvant NN cord-267001-csgmc155 299 38 in in IN cord-267001-csgmc155 299 39 combination combination NN cord-267001-csgmc155 299 40 with with IN cord-267001-csgmc155 299 41 other other JJ cord-267001-csgmc155 299 42 PRR PRR NNP cord-267001-csgmc155 299 43 agonists agonist NNS cord-267001-csgmc155 299 44 that that WDT cord-267001-csgmc155 299 45 can can MD cord-267001-csgmc155 299 46 be be VB cord-267001-csgmc155 299 47 used use VBN cord-267001-csgmc155 299 48 in in IN cord-267001-csgmc155 299 49 aqueous aqueous JJ cord-267001-csgmc155 299 50 formulations formulation NNS cord-267001-csgmc155 299 51 as as IN cord-267001-csgmc155 299 52 adjuvants adjuvant NNS cord-267001-csgmc155 299 53 in in IN cord-267001-csgmc155 299 54 novel novel JJ cord-267001-csgmc155 299 55 combinatorial combinatorial JJ cord-267001-csgmc155 299 56 formulations formulation NNS cord-267001-csgmc155 299 57 . . . cord-267001-csgmc155 300 1 Such such JJ cord-267001-csgmc155 300 2 combinatorial combinatorial JJ cord-267001-csgmc155 300 3 adjuvants adjuvant NNS cord-267001-csgmc155 300 4 may may MD cord-267001-csgmc155 300 5 be be VB cord-267001-csgmc155 300 6 more more RBR cord-267001-csgmc155 300 7 advantageous advantageous JJ cord-267001-csgmc155 300 8 with with IN cord-267001-csgmc155 300 9 subunit subunit NN cord-267001-csgmc155 300 10 vaccine vaccine NN cord-267001-csgmc155 300 11 models model NNS cord-267001-csgmc155 300 12 that that WDT cord-267001-csgmc155 300 13 generally generally RB cord-267001-csgmc155 300 14 are be VBP cord-267001-csgmc155 300 15 known know VBN cord-267001-csgmc155 300 16 to to TO cord-267001-csgmc155 300 17 induce induce VB cord-267001-csgmc155 300 18 suboptimal suboptimal JJ cord-267001-csgmc155 300 19 protective protective JJ cord-267001-csgmc155 300 20 immune immune JJ cord-267001-csgmc155 300 21 responses response NNS cord-267001-csgmc155 300 22 alone alone RB cord-267001-csgmc155 300 23 and/or and/or CC cord-267001-csgmc155 300 24 induce induce VB cord-267001-csgmc155 300 25 vaccine vaccine NN cord-267001-csgmc155 300 26 enhanced enhance VBN cord-267001-csgmc155 300 27 disease disease NN cord-267001-csgmc155 300 28 ( ( -LRB- cord-267001-csgmc155 300 29 VED VED NNP cord-267001-csgmc155 300 30 ) ) -RRB- cord-267001-csgmc155 300 31 when when WRB cord-267001-csgmc155 300 32 used use VBN cord-267001-csgmc155 300 33 with with IN cord-267001-csgmc155 300 34 the the DT cord-267001-csgmc155 300 35 alum alum NN cord-267001-csgmc155 300 36 adjuvant adjuvant JJ cord-267001-csgmc155 300 37 [ [ -LRB- cord-267001-csgmc155 300 38 46 46 CD cord-267001-csgmc155 300 39 ] ] -RRB- cord-267001-csgmc155 300 40 . . . cord-267001-csgmc155 301 1 The the DT cord-267001-csgmc155 301 2 following follow VBG cord-267001-csgmc155 301 3 are be VBP cord-267001-csgmc155 301 4 available available JJ cord-267001-csgmc155 301 5 online online RB cord-267001-csgmc155 301 6 at at IN cord-267001-csgmc155 301 7 http://www.mdpi.com/2076-393X/8/2/251/s1 http://www.mdpi.com/2076-393x/8/2/251/s1 ADD cord-267001-csgmc155 301 8 , , , cord-267001-csgmc155 301 9 Figure figure NN cord-267001-csgmc155 301 10 S1 s1 NN cord-267001-csgmc155 301 11 : : : cord-267001-csgmc155 301 12 Induction induction NN cord-267001-csgmc155 301 13 of of IN cord-267001-csgmc155 301 14 MERS MERS NNP cord-267001-csgmc155 301 15 - - HYPH cord-267001-csgmc155 301 16 CoV CoV NNP cord-267001-csgmc155 301 17 - - HYPH cord-267001-csgmc155 301 18 RBD RBD NNP cord-267001-csgmc155 301 19 specific specific JJ cord-267001-csgmc155 301 20 IgG igg NN cord-267001-csgmc155 301 21 subtypes subtype NNS cord-267001-csgmc155 301 22 in in IN cord-267001-csgmc155 301 23 sera sera NNP cord-267001-csgmc155 301 24 of of IN cord-267001-csgmc155 301 25 immunized immunize VBN cord-267001-csgmc155 301 26 mice mouse NNS cord-267001-csgmc155 301 27 , , , cord-267001-csgmc155 301 28 Figure figure NN cord-267001-csgmc155 301 29 S2 s2 NN cord-267001-csgmc155 301 30 : : : cord-267001-csgmc155 301 31 Representative representative JJ cord-267001-csgmc155 301 32 flow flow NN cord-267001-csgmc155 301 33 cytometry cytometry NN cord-267001-csgmc155 301 34 plot plot NN cord-267001-csgmc155 301 35 determining determine VBG cord-267001-csgmc155 301 36 the the DT cord-267001-csgmc155 301 37 gating gate VBG cord-267001-csgmc155 301 38 strategy strategy NN cord-267001-csgmc155 301 39 of of IN cord-267001-csgmc155 301 40 the the DT cord-267001-csgmc155 301 41 immune immune JJ cord-267001-csgmc155 301 42 cells cell NNS cord-267001-csgmc155 301 43 recruited recruit VBN cord-267001-csgmc155 301 44 to to IN cord-267001-csgmc155 301 45 the the DT cord-267001-csgmc155 301 46 draining drain VBG cord-267001-csgmc155 301 47 lymph lymph NN cord-267001-csgmc155 301 48 nodes node NNS cord-267001-csgmc155 301 49 ( ( -LRB- cord-267001-csgmc155 301 50 LNs LNs NNP cord-267001-csgmc155 301 51 ) ) -RRB- cord-267001-csgmc155 301 52 of of IN cord-267001-csgmc155 301 53 immunized immunize VBN cord-267001-csgmc155 301 54 mice mouse NNS cord-267001-csgmc155 301 55 , , , cord-267001-csgmc155 301 56 Figure figure NN cord-267001-csgmc155 301 57 S3 s3 NN cord-267001-csgmc155 301 58 : : : cord-267001-csgmc155 302 1 Number number NN cord-267001-csgmc155 302 2 of of IN cord-267001-csgmc155 302 3 monocyte monocyte NNP cord-267001-csgmc155 302 4 and and CC cord-267001-csgmc155 302 5 DC DC NNP cord-267001-csgmc155 302 6 subsets subset NNS cord-267001-csgmc155 302 7 recruited recruit VBN cord-267001-csgmc155 302 8 into into IN cord-267001-csgmc155 302 9 the the DT cord-267001-csgmc155 302 10 lymph lymph NN cord-267001-csgmc155 302 11 nodes node NNS cord-267001-csgmc155 302 12 ( ( -LRB- cord-267001-csgmc155 302 13 LNs LNs NNP cord-267001-csgmc155 302 14 ) ) -RRB- cord-267001-csgmc155 302 15 of of IN cord-267001-csgmc155 302 16 immunized immunize VBN cord-267001-csgmc155 302 17 mice mouse NNS cord-267001-csgmc155 302 18 , , , cord-267001-csgmc155 302 19 Figure figure NN cord-267001-csgmc155 302 20 S4 s4 NN cord-267001-csgmc155 302 21 : : : cord-267001-csgmc155 303 1 Frequency frequency NN cord-267001-csgmc155 303 2 of of IN cord-267001-csgmc155 303 3 CD4 CD4 NNP cord-267001-csgmc155 303 4 + + CC cord-267001-csgmc155 303 5 T T NNP cord-267001-csgmc155 303 6 cells cell NNS cord-267001-csgmc155 303 7 in in IN cord-267001-csgmc155 303 8 the the DT cord-267001-csgmc155 303 9 lymph lymph NN cord-267001-csgmc155 303 10 nodes node NNS cord-267001-csgmc155 303 11 ( ( -LRB- cord-267001-csgmc155 303 12 LNs LNs NNP cord-267001-csgmc155 303 13 ) ) -RRB- cord-267001-csgmc155 303 14 of of IN cord-267001-csgmc155 303 15 immunized immunize VBN cord-267001-csgmc155 303 16 mice mouse NNS cord-267001-csgmc155 303 17 . . . cord-267001-csgmc155 304 1 Funding funding NN cord-267001-csgmc155 304 2 : : : cord-267001-csgmc155 305 1 This this DT cord-267001-csgmc155 305 2 research research NN cord-267001-csgmc155 305 3 was be VBD cord-267001-csgmc155 305 4 funded fund VBN cord-267001-csgmc155 305 5 by by IN cord-267001-csgmc155 305 6 NIH NIH NNP cord-267001-csgmc155 305 7 grants grant NNS cord-267001-csgmc155 305 8 U01AI124260 U01AI124260 NNP cord-267001-csgmc155 305 9 and and CC cord-267001-csgmc155 305 10 R01AI139092 R01AI139092 NNP cord-267001-csgmc155 305 11 . . . cord-267001-csgmc155 306 1 Recent recent JJ cord-267001-csgmc155 306 2 advances advance NNS cord-267001-csgmc155 306 3 of of IN cord-267001-csgmc155 306 4 vaccine vaccine NN cord-267001-csgmc155 306 5 adjuvants adjuvant NNS cord-267001-csgmc155 306 6 for for IN cord-267001-csgmc155 306 7 infectious infectious JJ cord-267001-csgmc155 306 8 diseases disease NNS cord-267001-csgmc155 307 1 The the DT cord-267001-csgmc155 307 2 latest late JJS cord-267001-csgmc155 307 3 advancements advancement NNS cord-267001-csgmc155 307 4 in in IN cord-267001-csgmc155 307 5 Zika Zika NNP cord-267001-csgmc155 307 6 virus virus NN cord-267001-csgmc155 307 7 vaccine vaccine NN cord-267001-csgmc155 307 8 development development NN cord-267001-csgmc155 307 9 Augmentation augmentation NN cord-267001-csgmc155 307 10 of of IN cord-267001-csgmc155 307 11 vaccine vaccine NN cord-267001-csgmc155 307 12 - - HYPH cord-267001-csgmc155 307 13 induced induce VBN cord-267001-csgmc155 307 14 humoral humoral JJ cord-267001-csgmc155 307 15 and and CC cord-267001-csgmc155 307 16 cellular cellular JJ cord-267001-csgmc155 307 17 immunity immunity NN cord-267001-csgmc155 307 18 by by IN cord-267001-csgmc155 307 19 a a DT cord-267001-csgmc155 307 20 physical physical JJ cord-267001-csgmc155 307 21 radiofrequency radiofrequency NN cord-267001-csgmc155 307 22 adjuvant adjuvant JJ cord-267001-csgmc155 307 23 From from IN cord-267001-csgmc155 307 24 1920 1920 CD cord-267001-csgmc155 307 25 to to IN cord-267001-csgmc155 307 26 2015 2015 CD cord-267001-csgmc155 307 27 and and CC cord-267001-csgmc155 307 28 Beyond Beyond NNP cord-267001-csgmc155 307 29 . . . cord-267001-csgmc155 308 1 Vaccines vaccine NNS cord-267001-csgmc155 308 2 ( ( -LRB- cord-267001-csgmc155 308 3 Basel Basel NNP cord-267001-csgmc155 308 4 ) ) -RRB- cord-267001-csgmc155 308 5 Aluminium aluminium NN cord-267001-csgmc155 308 6 adjuvants adjuvant NNS cord-267001-csgmc155 308 7 - - : cord-267001-csgmc155 308 8 in in IN cord-267001-csgmc155 308 9 retrospect retrospect JJ cord-267001-csgmc155 308 10 and and CC cord-267001-csgmc155 308 11 prospect prospect NN cord-267001-csgmc155 308 12 Optimizing optimize VBG cord-267001-csgmc155 308 13 the the DT cord-267001-csgmc155 308 14 utilization utilization NN cord-267001-csgmc155 308 15 of of IN cord-267001-csgmc155 308 16 aluminum aluminum NN cord-267001-csgmc155 308 17 adjuvants adjuvant NNS cord-267001-csgmc155 308 18 in in IN cord-267001-csgmc155 308 19 vaccines vaccine NNS cord-267001-csgmc155 308 20 : : : cord-267001-csgmc155 308 21 You -PRON- PRP cord-267001-csgmc155 308 22 might may MD cord-267001-csgmc155 308 23 just just RB cord-267001-csgmc155 308 24 get get VB cord-267001-csgmc155 308 25 what what WP cord-267001-csgmc155 308 26 you -PRON- PRP cord-267001-csgmc155 308 27 want want VBP cord-267001-csgmc155 308 28 Old old JJ cord-267001-csgmc155 308 29 and and CC cord-267001-csgmc155 308 30 new new JJ cord-267001-csgmc155 308 31 adjuvants adjuvant NNS cord-267001-csgmc155 308 32 -1 -1 NN cord-267001-csgmc155 308 33 , , , cord-267001-csgmc155 308 34 a a DT cord-267001-csgmc155 308 35 Th1-biased th1-biase VBN cord-267001-csgmc155 308 36 protein protein NN cord-267001-csgmc155 308 37 adjuvant adjuvant NN cord-267001-csgmc155 308 38 derived derive VBN cord-267001-csgmc155 308 39 from from IN cord-267001-csgmc155 308 40 the the DT cord-267001-csgmc155 308 41 helminth helminth JJ cord-267001-csgmc155 308 42 Onchocerca Onchocerca NNP cord-267001-csgmc155 308 43 volvulus volvulus NN cord-267001-csgmc155 308 44 , , , cord-267001-csgmc155 308 45 can can MD cord-267001-csgmc155 308 46 directly directly RB cord-267001-csgmc155 308 47 bind bind VB cord-267001-csgmc155 308 48 and and CC cord-267001-csgmc155 308 49 activate activate VB cord-267001-csgmc155 308 50 antigen antigen NN cord-267001-csgmc155 308 51 - - HYPH cord-267001-csgmc155 308 52 presenting present VBG cord-267001-csgmc155 308 53 cells cell NNS cord-267001-csgmc155 309 1 The the DT cord-267001-csgmc155 309 2 adjuvanticity adjuvanticity NN cord-267001-csgmc155 309 3 of of IN cord-267001-csgmc155 309 4 an an DT cord-267001-csgmc155 309 5 O. O. NNP cord-267001-csgmc155 309 6 volvulus volvulus NN cord-267001-csgmc155 309 7 - - HYPH cord-267001-csgmc155 309 8 derived derive VBN cord-267001-csgmc155 309 9 rOv rov NN cord-267001-csgmc155 309 10 - - HYPH cord-267001-csgmc155 309 11 ASP-1 ASP-1 NNP cord-267001-csgmc155 309 12 protein protein NN cord-267001-csgmc155 309 13 in in IN cord-267001-csgmc155 309 14 mice mouse NNS cord-267001-csgmc155 309 15 using use VBG cord-267001-csgmc155 309 16 sequential sequential JJ cord-267001-csgmc155 309 17 vaccinations vaccination NNS cord-267001-csgmc155 309 18 and and CC cord-267001-csgmc155 309 19 in in IN cord-267001-csgmc155 309 20 non non JJ cord-267001-csgmc155 309 21 - - JJ cord-267001-csgmc155 309 22 human human JJ cord-267001-csgmc155 309 23 primates primate NNS cord-267001-csgmc155 309 24 ASP-1 ASP-1 NNP cord-267001-csgmc155 309 25 , , , cord-267001-csgmc155 309 26 a a DT cord-267001-csgmc155 309 27 recombinant recombinant JJ cord-267001-csgmc155 309 28 secreted secrete VBN cord-267001-csgmc155 309 29 protein protein NN cord-267001-csgmc155 309 30 of of IN cord-267001-csgmc155 309 31 the the DT cord-267001-csgmc155 309 32 helminth helminth JJ cord-267001-csgmc155 309 33 Onchocercavolvulus Onchocercavolvulus NNP cord-267001-csgmc155 309 34 , , , cord-267001-csgmc155 309 35 is be VBZ cord-267001-csgmc155 309 36 a a DT cord-267001-csgmc155 309 37 potent potent JJ cord-267001-csgmc155 309 38 adjuvant adjuvant NN cord-267001-csgmc155 309 39 for for IN cord-267001-csgmc155 309 40 inducing induce VBG cord-267001-csgmc155 309 41 antibodies antibody NNS cord-267001-csgmc155 309 42 to to IN cord-267001-csgmc155 309 43 ovalbumin ovalbumin NNP cord-267001-csgmc155 309 44 , , , cord-267001-csgmc155 309 45 HIV-1 HIV-1 NNP cord-267001-csgmc155 309 46 polypeptide polypeptide NN cord-267001-csgmc155 309 47 and and CC cord-267001-csgmc155 310 1 SARS SARS NNP cord-267001-csgmc155 310 2 - - HYPH cord-267001-csgmc155 310 3 CoV CoV NNP cord-267001-csgmc155 310 4 peptide peptide NN cord-267001-csgmc155 310 5 antigens antigen NNS cord-267001-csgmc155 310 6 Enhanced Enhanced NNP cord-267001-csgmc155 310 7 humoral humoral JJ cord-267001-csgmc155 310 8 response response NN cord-267001-csgmc155 310 9 to to IN cord-267001-csgmc155 310 10 influenza influenza NN cord-267001-csgmc155 310 11 vaccine vaccine NN cord-267001-csgmc155 310 12 in in IN cord-267001-csgmc155 310 13 aged aged JJ cord-267001-csgmc155 310 14 mice mouse NNS cord-267001-csgmc155 310 15 with with IN cord-267001-csgmc155 310 16 a a DT cord-267001-csgmc155 310 17 novel novel NN cord-267001-csgmc155 310 18 adjuvant adjuvant NN cord-267001-csgmc155 310 19 , , , cord-267001-csgmc155 310 20 rOv rOv NNP cord-267001-csgmc155 310 21 - - HYPH cord-267001-csgmc155 310 22 ASP-1 ASP-1 NNP cord-267001-csgmc155 310 23 . . . cord-267001-csgmc155 311 1 Vaccine vaccine NN cord-267001-csgmc155 312 1 The the DT cord-267001-csgmc155 312 2 parasite parasite NN cord-267001-csgmc155 312 3 - - HYPH cord-267001-csgmc155 312 4 derived derive VBN cord-267001-csgmc155 312 5 rOv rov NN cord-267001-csgmc155 312 6 - - : cord-267001-csgmc155 312 7 ASP-1 ASP-1 NNP cord-267001-csgmc155 312 8 is be VBZ cord-267001-csgmc155 312 9 an an DT cord-267001-csgmc155 312 10 effective effective JJ cord-267001-csgmc155 312 11 antigen antigen NN cord-267001-csgmc155 312 12 - - HYPH cord-267001-csgmc155 312 13 sparing spare VBG cord-267001-csgmc155 312 14 CD4(+ CD4(+ NNS cord-267001-csgmc155 312 15 ) ) -RRB- cord-267001-csgmc155 313 1 T T NNP cord-267001-csgmc155 313 2 cell cell NN cord-267001-csgmc155 313 3 - - HYPH cord-267001-csgmc155 313 4 dependent dependent JJ cord-267001-csgmc155 313 5 adjuvant adjuvant NN cord-267001-csgmc155 313 6 for for IN cord-267001-csgmc155 313 7 the the DT cord-267001-csgmc155 313 8 trivalent trivalent JJ cord-267001-csgmc155 313 9 inactivated inactivate VBN cord-267001-csgmc155 313 10 influenza influenza NN cord-267001-csgmc155 313 11 vaccine vaccine NN cord-267001-csgmc155 313 12 , , , cord-267001-csgmc155 313 13 and and CC cord-267001-csgmc155 313 14 functions function NNS cord-267001-csgmc155 313 15 in in IN cord-267001-csgmc155 313 16 the the DT cord-267001-csgmc155 313 17 absence absence NN cord-267001-csgmc155 313 18 of of IN cord-267001-csgmc155 313 19 MyD88 myd88 JJ cord-267001-csgmc155 313 20 pathway pathway NN cord-267001-csgmc155 313 21 Isolation isolation NN cord-267001-csgmc155 313 22 of of IN cord-267001-csgmc155 313 23 a a DT cord-267001-csgmc155 313 24 novel novel JJ cord-267001-csgmc155 313 25 coronavirus coronavirus NN cord-267001-csgmc155 313 26 from from IN cord-267001-csgmc155 313 27 a a DT cord-267001-csgmc155 313 28 man man NN cord-267001-csgmc155 313 29 with with IN cord-267001-csgmc155 313 30 pneumonia pneumonia NN cord-267001-csgmc155 313 31 in in IN cord-267001-csgmc155 313 32 Saudi Saudi NNP cord-267001-csgmc155 313 33 Arabia Arabia NNP cord-267001-csgmc155 313 34 Crystal Crystal NNP cord-267001-csgmc155 313 35 structure structure NN cord-267001-csgmc155 313 36 of of IN cord-267001-csgmc155 313 37 the the DT cord-267001-csgmc155 313 38 receptor receptor NN cord-267001-csgmc155 313 39 - - HYPH cord-267001-csgmc155 313 40 binding bind VBG cord-267001-csgmc155 313 41 domain domain NN cord-267001-csgmc155 313 42 from from IN cord-267001-csgmc155 313 43 newly newly RB cord-267001-csgmc155 313 44 emerged emerge VBN cord-267001-csgmc155 313 45 Middle Middle NNP cord-267001-csgmc155 313 46 East East NNP cord-267001-csgmc155 313 47 respiratory respiratory JJ cord-267001-csgmc155 313 48 syndrome syndrome NN cord-267001-csgmc155 313 49 coronavirus coronavirus NN cord-267001-csgmc155 313 50 Dipeptidyl Dipeptidyl NNP cord-267001-csgmc155 313 51 peptidase peptidase NN cord-267001-csgmc155 313 52 4 4 CD cord-267001-csgmc155 313 53 is be VBZ cord-267001-csgmc155 313 54 a a DT cord-267001-csgmc155 313 55 functional functional JJ cord-267001-csgmc155 313 56 receptor receptor NN cord-267001-csgmc155 313 57 for for IN cord-267001-csgmc155 313 58 the the DT cord-267001-csgmc155 313 59 emerging emerge VBG cord-267001-csgmc155 313 60 human human JJ cord-267001-csgmc155 313 61 coronavirus coronavirus NN cord-267001-csgmc155 313 62 - - HYPH cord-267001-csgmc155 313 63 EMC EMC NNP cord-267001-csgmc155 313 64 Advances advance VBZ cord-267001-csgmc155 313 65 in in IN cord-267001-csgmc155 313 66 MERS MERS NNP cord-267001-csgmc155 313 67 - - HYPH cord-267001-csgmc155 313 68 CoV CoV NNP cord-267001-csgmc155 313 69 Vaccines Vaccines NNPS cord-267001-csgmc155 313 70 and and CC cord-267001-csgmc155 313 71 Therapeutics Therapeutics NNP cord-267001-csgmc155 313 72 Based Based NNP cord-267001-csgmc155 313 73 on on IN cord-267001-csgmc155 313 74 the the DT cord-267001-csgmc155 313 75 Receptor receptor NN cord-267001-csgmc155 313 76 - - HYPH cord-267001-csgmc155 313 77 Binding bind VBG cord-267001-csgmc155 313 78 Domain Domain NNP cord-267001-csgmc155 313 79 Recombinant Recombinant NNP cord-267001-csgmc155 313 80 Receptor Receptor NNP cord-267001-csgmc155 313 81 - - HYPH cord-267001-csgmc155 313 82 Binding bind VBG cord-267001-csgmc155 313 83 Domains domain NNS cord-267001-csgmc155 313 84 of of IN cord-267001-csgmc155 313 85 Multiple Multiple NNP cord-267001-csgmc155 313 86 Middle Middle NNP cord-267001-csgmc155 313 87 East East NNP cord-267001-csgmc155 313 88 Respiratory Respiratory NNP cord-267001-csgmc155 313 89 Syndrome Syndrome NNP cord-267001-csgmc155 313 90 Coronaviruses Coronaviruses NNP cord-267001-csgmc155 313 91 ( ( -LRB- cord-267001-csgmc155 313 92 MERS MERS NNP cord-267001-csgmc155 313 93 - - HYPH cord-267001-csgmc155 313 94 CoVs CoVs NNP cord-267001-csgmc155 313 95 ) ) -RRB- cord-267001-csgmc155 314 1 Induce induce VB cord-267001-csgmc155 314 2 Cross Cross NNP cord-267001-csgmc155 314 3 - - HYPH cord-267001-csgmc155 314 4 Neutralizing neutralize VBG cord-267001-csgmc155 314 5 Antibodies Antibodies NNPS cord-267001-csgmc155 314 6 against against IN cord-267001-csgmc155 314 7 Divergent Divergent NNP cord-267001-csgmc155 314 8 Human Human NNP cord-267001-csgmc155 314 9 and and CC cord-267001-csgmc155 314 10 Camel Camel NNP cord-267001-csgmc155 314 11 MERS MERS NNP cord-267001-csgmc155 314 12 - - HYPH cord-267001-csgmc155 314 13 CoVs CoVs NNP cord-267001-csgmc155 314 14 and and CC cord-267001-csgmc155 314 15 Antibody Antibody NNP cord-267001-csgmc155 314 16 Escape Escape NNP cord-267001-csgmc155 314 17 Mutants Mutants NNPS cord-267001-csgmc155 314 18 Receptor receptor NN cord-267001-csgmc155 314 19 - - HYPH cord-267001-csgmc155 314 20 binding bind VBG cord-267001-csgmc155 314 21 domain domain NN cord-267001-csgmc155 314 22 of of IN cord-267001-csgmc155 314 23 MERS MERS NNP cord-267001-csgmc155 314 24 - - HYPH cord-267001-csgmc155 314 25 CoV CoV NNP cord-267001-csgmc155 314 26 with with IN cord-267001-csgmc155 314 27 optimal optimal JJ cord-267001-csgmc155 314 28 immunogen immunogen NN cord-267001-csgmc155 314 29 dosage dosage NN cord-267001-csgmc155 314 30 and and CC cord-267001-csgmc155 314 31 immunization immunization NN cord-267001-csgmc155 314 32 interval interval NN cord-267001-csgmc155 314 33 protects protect VBZ cord-267001-csgmc155 314 34 human human JJ cord-267001-csgmc155 314 35 transgenic transgenic JJ cord-267001-csgmc155 314 36 mice mouse NNS cord-267001-csgmc155 314 37 from from IN cord-267001-csgmc155 314 38 MERS MERS NNP cord-267001-csgmc155 314 39 - - HYPH cord-267001-csgmc155 314 40 CoV CoV NNP cord-267001-csgmc155 314 41 infection infection NN cord-267001-csgmc155 315 1 Introduction introduction NN cord-267001-csgmc155 315 2 of of IN cord-267001-csgmc155 315 3 neutralizing neutralize VBG cord-267001-csgmc155 315 4 immunogenicity immunogenicity NN cord-267001-csgmc155 315 5 index index NN cord-267001-csgmc155 315 6 to to IN cord-267001-csgmc155 315 7 the the DT cord-267001-csgmc155 315 8 rational rational JJ cord-267001-csgmc155 315 9 design design NN cord-267001-csgmc155 315 10 of of IN cord-267001-csgmc155 315 11 MERS MERS NNP cord-267001-csgmc155 315 12 coronavirus coronavirus NN cord-267001-csgmc155 315 13 subunit subunit NN cord-267001-csgmc155 315 14 vaccines vaccine VBZ cord-267001-csgmc155 315 15 A a DT cord-267001-csgmc155 315 16 recombinant recombinant JJ cord-267001-csgmc155 315 17 receptor receptor NN cord-267001-csgmc155 315 18 - - HYPH cord-267001-csgmc155 315 19 binding bind VBG cord-267001-csgmc155 315 20 domain domain NN cord-267001-csgmc155 315 21 of of IN cord-267001-csgmc155 315 22 MERS MERS NNP cord-267001-csgmc155 315 23 - - HYPH cord-267001-csgmc155 315 24 CoV CoV NNP cord-267001-csgmc155 315 25 in in IN cord-267001-csgmc155 315 26 trimeric trimeric NNP cord-267001-csgmc155 315 27 form form NN cord-267001-csgmc155 315 28 protects protect VBZ cord-267001-csgmc155 315 29 human human JJ cord-267001-csgmc155 315 30 dipeptidyl dipeptidyl JJ cord-267001-csgmc155 315 31 peptidase peptidase NNP cord-267001-csgmc155 315 32 4 4 CD cord-267001-csgmc155 315 33 ( ( -LRB- cord-267001-csgmc155 315 34 hDPP4 hdpp4 NN cord-267001-csgmc155 315 35 ) ) -RRB- cord-267001-csgmc155 315 36 transgenic transgenic JJ cord-267001-csgmc155 315 37 mice mouse NNS cord-267001-csgmc155 315 38 from from IN cord-267001-csgmc155 315 39 MERS MERS NNP cord-267001-csgmc155 315 40 - - HYPH cord-267001-csgmc155 315 41 CoV CoV NNP cord-267001-csgmc155 315 42 infection infection NN cord-267001-csgmc155 315 43 Combinatorial Combinatorial NNP cord-267001-csgmc155 315 44 Delivery Delivery NNP cord-267001-csgmc155 315 45 of of IN cord-267001-csgmc155 315 46 Dual Dual NNP cord-267001-csgmc155 315 47 and and CC cord-267001-csgmc155 315 48 Triple triple JJ cord-267001-csgmc155 315 49 TLR TLR NNP cord-267001-csgmc155 315 50 Agonists Agonists NNPS cord-267001-csgmc155 315 51 via via IN cord-267001-csgmc155 315 52 Polymeric Polymeric NNP cord-267001-csgmc155 315 53 Pathogen Pathogen NNP cord-267001-csgmc155 315 54 - - HYPH cord-267001-csgmc155 315 55 like like JJ cord-267001-csgmc155 315 56 Particles particle NNS cord-267001-csgmc155 315 57 Synergistically synergistically RB cord-267001-csgmc155 315 58 Enhances enhance VBZ cord-267001-csgmc155 315 59 Innate innate JJ cord-267001-csgmc155 315 60 and and CC cord-267001-csgmc155 315 61 Adaptive Adaptive NNP cord-267001-csgmc155 315 62 Immune Immune NNP cord-267001-csgmc155 315 63 Responses Responses NNPS cord-267001-csgmc155 316 1 The the DT cord-267001-csgmc155 316 2 novel novel JJ cord-267001-csgmc155 316 3 complex complex JJ cord-267001-csgmc155 316 4 combination combination NN cord-267001-csgmc155 316 5 of of IN cord-267001-csgmc155 316 6 alum alum NN cord-267001-csgmc155 316 7 , , , cord-267001-csgmc155 316 8 CpG CpG NNP cord-267001-csgmc155 316 9 ODN ODN NNP cord-267001-csgmc155 316 10 and and CC cord-267001-csgmc155 316 11 HH2 HH2 NNP cord-267001-csgmc155 316 12 as as IN cord-267001-csgmc155 316 13 adjuvant adjuvant JJ cord-267001-csgmc155 316 14 in in IN cord-267001-csgmc155 316 15 cancer cancer NN cord-267001-csgmc155 316 16 vaccine vaccine NN cord-267001-csgmc155 316 17 effectively effectively RB cord-267001-csgmc155 316 18 suppresses suppress VBZ cord-267001-csgmc155 316 19 tumor tumor NN cord-267001-csgmc155 316 20 growth growth NN cord-267001-csgmc155 316 21 in in IN cord-267001-csgmc155 316 22 vivo vivo NNP cord-267001-csgmc155 316 23 Combination combination NN cord-267001-csgmc155 316 24 of of IN cord-267001-csgmc155 316 25 adjuvants adjuvant NNS cord-267001-csgmc155 316 26 : : : cord-267001-csgmc155 317 1 The the DT cord-267001-csgmc155 317 2 future future NN cord-267001-csgmc155 317 3 of of IN cord-267001-csgmc155 317 4 vaccine vaccine NN cord-267001-csgmc155 317 5 design design NN cord-267001-csgmc155 317 6 Hookworm hookworm NN cord-267001-csgmc155 317 7 burden burden NN cord-267001-csgmc155 317 8 reductions reduction NNS cord-267001-csgmc155 317 9 in in IN cord-267001-csgmc155 317 10 BALB BALB NNP cord-267001-csgmc155 317 11 / / SYM cord-267001-csgmc155 317 12 c c NN cord-267001-csgmc155 317 13 mice mouse NNS cord-267001-csgmc155 317 14 vaccinated vaccinate VBN cord-267001-csgmc155 317 15 with with IN cord-267001-csgmc155 317 16 recombinant recombinant JJ cord-267001-csgmc155 317 17 Ancylostoma Ancylostoma NNP cord-267001-csgmc155 317 18 secreted secrete VBD cord-267001-csgmc155 317 19 proteins protein NNS cord-267001-csgmc155 317 20 ( ( -LRB- cord-267001-csgmc155 317 21 ASPs asp NNS cord-267001-csgmc155 317 22 ) ) -RRB- cord-267001-csgmc155 317 23 from from IN cord-267001-csgmc155 317 24 Ancylostoma Ancylostoma NNP cord-267001-csgmc155 317 25 duodenale duodenale NNP cord-267001-csgmc155 317 26 , , , cord-267001-csgmc155 317 27 Ancylostoma Ancylostoma NNP cord-267001-csgmc155 317 28 caninum caninum NN cord-267001-csgmc155 317 29 and and CC cord-267001-csgmc155 317 30 Necator Necator NNP cord-267001-csgmc155 317 31 americanus americanus NN cord-267001-csgmc155 317 32 Theoretical theoretical JJ cord-267001-csgmc155 317 33 basis basis NN cord-267001-csgmc155 317 34 , , , cord-267001-csgmc155 317 35 experimental experimental JJ cord-267001-csgmc155 317 36 design design NN cord-267001-csgmc155 317 37 , , , cord-267001-csgmc155 317 38 and and CC cord-267001-csgmc155 317 39 computerized computerized JJ cord-267001-csgmc155 317 40 simulation simulation NN cord-267001-csgmc155 317 41 of of IN cord-267001-csgmc155 317 42 synergism synergism NN cord-267001-csgmc155 317 43 and and CC cord-267001-csgmc155 317 44 antagonism antagonism NN cord-267001-csgmc155 317 45 in in IN cord-267001-csgmc155 317 46 drug drug NN cord-267001-csgmc155 317 47 combination combination NN cord-267001-csgmc155 317 48 studies study NNS cord-267001-csgmc155 317 49 Identification Identification NNP cord-267001-csgmc155 317 50 of of IN cord-267001-csgmc155 317 51 a a DT cord-267001-csgmc155 317 52 receptor receptor NN cord-267001-csgmc155 317 53 - - HYPH cord-267001-csgmc155 317 54 binding bind VBG cord-267001-csgmc155 317 55 domain domain NN cord-267001-csgmc155 317 56 in in IN cord-267001-csgmc155 317 57 the the DT cord-267001-csgmc155 317 58 S S NNP cord-267001-csgmc155 317 59 protein protein NN cord-267001-csgmc155 317 60 of of IN cord-267001-csgmc155 317 61 the the DT cord-267001-csgmc155 317 62 novel novel JJ cord-267001-csgmc155 317 63 human human JJ cord-267001-csgmc155 317 64 coronavirus coronavirus NN cord-267001-csgmc155 317 65 Middle Middle NNP cord-267001-csgmc155 317 66 East East NNP cord-267001-csgmc155 317 67 respiratory respiratory JJ cord-267001-csgmc155 317 68 syndrome syndrome NN cord-267001-csgmc155 317 69 coronavirus coronavirus NN cord-267001-csgmc155 317 70 as as IN cord-267001-csgmc155 317 71 an an DT cord-267001-csgmc155 317 72 essential essential JJ cord-267001-csgmc155 317 73 target target NN cord-267001-csgmc155 317 74 for for IN cord-267001-csgmc155 317 75 vaccine vaccine NN cord-267001-csgmc155 317 76 development development NN cord-267001-csgmc155 317 77 Dendritic dendritic JJ cord-267001-csgmc155 317 78 cell cell NN cord-267001-csgmc155 317 79 migration migration NN cord-267001-csgmc155 317 80 to to IN cord-267001-csgmc155 317 81 peripheral peripheral JJ cord-267001-csgmc155 317 82 lymph lymph NN cord-267001-csgmc155 317 83 nodes node NNS cord-267001-csgmc155 317 84 Vaccine Vaccine NNP cord-267001-csgmc155 317 85 safety safety NN cord-267001-csgmc155 317 86 evaluation evaluation NN cord-267001-csgmc155 317 87 : : : cord-267001-csgmc155 317 88 Practical practical JJ cord-267001-csgmc155 317 89 aspects aspect NNS cord-267001-csgmc155 317 90 in in IN cord-267001-csgmc155 317 91 assessing assess VBG cord-267001-csgmc155 317 92 benefits benefit NNS cord-267001-csgmc155 317 93 and and CC cord-267001-csgmc155 317 94 risks risk NNS cord-267001-csgmc155 317 95 Efficacy efficacy NN cord-267001-csgmc155 317 96 and and CC cord-267001-csgmc155 317 97 safety safety NN cord-267001-csgmc155 317 98 of of IN cord-267001-csgmc155 317 99 immunological immunological JJ cord-267001-csgmc155 317 100 adjuvants adjuvant NNS cord-267001-csgmc155 317 101 . . . cord-267001-csgmc155 318 1 Where where WRB cord-267001-csgmc155 318 2 is be VBZ cord-267001-csgmc155 318 3 the the DT cord-267001-csgmc155 318 4 cut cut NN cord-267001-csgmc155 318 5 - - HYPH cord-267001-csgmc155 318 6 off off RP cord-267001-csgmc155 318 7 ? ? . cord-267001-csgmc155 319 1 Advances advance NNS cord-267001-csgmc155 319 2 in in IN cord-267001-csgmc155 319 3 aluminum aluminum NN cord-267001-csgmc155 319 4 hydroxide hydroxide NN cord-267001-csgmc155 319 5 - - HYPH cord-267001-csgmc155 319 6 based base VBN cord-267001-csgmc155 319 7 adjuvant adjuvant NN cord-267001-csgmc155 319 8 research research NN cord-267001-csgmc155 319 9 and and CC cord-267001-csgmc155 319 10 its -PRON- PRP$ cord-267001-csgmc155 319 11 mechanism mechanism NN cord-267001-csgmc155 319 12 From from IN cord-267001-csgmc155 319 13 discovery discovery NN cord-267001-csgmc155 319 14 to to IN cord-267001-csgmc155 319 15 licensure licensure NN cord-267001-csgmc155 319 16 , , , cord-267001-csgmc155 319 17 the the DT cord-267001-csgmc155 319 18 Adjuvant Adjuvant NNP cord-267001-csgmc155 319 19 System System NNP cord-267001-csgmc155 319 20 story story NN cord-267001-csgmc155 319 21 Triggering trigger VBG cord-267001-csgmc155 319 22 Intracellular Intracellular NNP cord-267001-csgmc155 319 23 Receptors Receptors NNPS cord-267001-csgmc155 319 24 for for IN cord-267001-csgmc155 319 25 Vaccine Vaccine NNP cord-267001-csgmc155 319 26 Adjuvantation Adjuvantation NNP cord-267001-csgmc155 319 27 Mucosal Mucosal NNP cord-267001-csgmc155 319 28 delivery delivery NN cord-267001-csgmc155 319 29 of of IN cord-267001-csgmc155 319 30 a a DT cord-267001-csgmc155 319 31 combination combination NN cord-267001-csgmc155 319 32 adjuvant adjuvant NN cord-267001-csgmc155 319 33 comprising comprise VBG cord-267001-csgmc155 319 34 emulsified emulsify VBN cord-267001-csgmc155 319 35 fine fine JJ cord-267001-csgmc155 319 36 particles particle NNS cord-267001-csgmc155 319 37 and and CC cord-267001-csgmc155 319 38 LD LD NNP cord-267001-csgmc155 319 39 - - HYPH cord-267001-csgmc155 319 40 indolicidin indolicidin NNP cord-267001-csgmc155 319 41 enhances enhance VBZ cord-267001-csgmc155 319 42 serological serological JJ cord-267001-csgmc155 319 43 immunity immunity NN cord-267001-csgmc155 319 44 to to IN cord-267001-csgmc155 319 45 inactivated inactivate VBN cord-267001-csgmc155 319 46 influenza influenza NN cord-267001-csgmc155 319 47 virus virus NN cord-267001-csgmc155 319 48 MPL MPL NNP cord-267001-csgmc155 319 49 and and CC cord-267001-csgmc155 319 50 CpG CpG NNP cord-267001-csgmc155 319 51 combination combination NN cord-267001-csgmc155 319 52 adjuvants adjuvant NNS cord-267001-csgmc155 319 53 promote promote VBP cord-267001-csgmc155 319 54 homologous homologous JJ cord-267001-csgmc155 319 55 and and CC cord-267001-csgmc155 319 56 heterosubtypic heterosubtypic NNP cord-267001-csgmc155 319 57 cross cross NNP cord-267001-csgmc155 319 58 protection protection NNP cord-267001-csgmc155 319 59 of of IN cord-267001-csgmc155 319 60 inactivated inactivated JJ cord-267001-csgmc155 319 61 split split NN cord-267001-csgmc155 319 62 influenza influenza NN cord-267001-csgmc155 319 63 virus virus NN cord-267001-csgmc155 319 64 vaccine vaccine NN cord-267001-csgmc155 319 65 Alum Alum NNP cord-267001-csgmc155 319 66 / / SYM cord-267001-csgmc155 319 67 Toll Toll NNP cord-267001-csgmc155 319 68 - - HYPH cord-267001-csgmc155 319 69 Like Like NNP cord-267001-csgmc155 319 70 Receptor Receptor NNP cord-267001-csgmc155 319 71 7 7 CD cord-267001-csgmc155 319 72 Adjuvant Adjuvant NNP cord-267001-csgmc155 319 73 Enhances enhance VBZ cord-267001-csgmc155 319 74 the the DT cord-267001-csgmc155 319 75 Expansion Expansion NNP cord-267001-csgmc155 319 76 of of IN cord-267001-csgmc155 319 77 Memory Memory NNP cord-267001-csgmc155 319 78 B B NNP cord-267001-csgmc155 319 79 Cell Cell NNP cord-267001-csgmc155 319 80 Compartment Compartment NNP cord-267001-csgmc155 319 81 Within within IN cord-267001-csgmc155 319 82 the the DT cord-267001-csgmc155 319 83 Draining drain VBG cord-267001-csgmc155 319 84 Lymph lymph NN cord-267001-csgmc155 319 85 Node Node NNP cord-267001-csgmc155 319 86 Evaluation Evaluation NNP cord-267001-csgmc155 319 87 of of IN cord-267001-csgmc155 319 88 hyaluronic hyaluronic NN cord-267001-csgmc155 319 89 acid acid NN cord-267001-csgmc155 319 90 - - HYPH cord-267001-csgmc155 319 91 based base VBN cord-267001-csgmc155 319 92 combination combination NN cord-267001-csgmc155 319 93 adjuvant adjuvant NN cord-267001-csgmc155 319 94 containing contain VBG cord-267001-csgmc155 319 95 monophosphoryl monophosphoryl NNP cord-267001-csgmc155 319 96 lipid lipid VBG cord-267001-csgmc155 319 97 A A NNP cord-267001-csgmc155 319 98 and and CC cord-267001-csgmc155 319 99 aluminum aluminum NN cord-267001-csgmc155 319 100 salt salt NN cord-267001-csgmc155 319 101 for for IN cord-267001-csgmc155 319 102 hepatitis hepatitis NN cord-267001-csgmc155 319 103 B B NNP cord-267001-csgmc155 319 104 vaccine vaccine NN cord-267001-csgmc155 320 1 The the DT cord-267001-csgmc155 320 2 potential potential JJ cord-267001-csgmc155 320 3 danger danger NN cord-267001-csgmc155 320 4 of of IN cord-267001-csgmc155 320 5 suboptimal suboptimal JJ cord-267001-csgmc155 320 6 antibody antibody NN cord-267001-csgmc155 320 7 responses response NNS cord-267001-csgmc155 320 8 in in IN cord-267001-csgmc155 320 9 COVID-19 COVID-19 NNP cord-267001-csgmc155 320 10 cross cross NN cord-267001-csgmc155 320 11 - - NN cord-267001-csgmc155 320 12 reactivity reactivity NN cord-267001-csgmc155 320 13 , , , cord-267001-csgmc155 320 14 and and CC cord-267001-csgmc155 320 15 function function NN cord-267001-csgmc155 320 16 of of IN cord-267001-csgmc155 320 17 antibodies antibody NNS cord-267001-csgmc155 320 18 elicited elicit VBN cord-267001-csgmc155 320 19 by by IN cord-267001-csgmc155 320 20 Zika Zika NNP cord-267001-csgmc155 320 21 virus virus NN cord-267001-csgmc155 320 22 infection infection NN cord-267001-csgmc155 320 23 Engineering engineer VBG cord-267001-csgmc155 320 24 a a DT cord-267001-csgmc155 320 25 stable stable JJ cord-267001-csgmc155 320 26 CHO CHO NNP cord-267001-csgmc155 320 27 cell cell NN cord-267001-csgmc155 320 28 line line NN cord-267001-csgmc155 320 29 for for IN cord-267001-csgmc155 320 30 the the DT cord-267001-csgmc155 320 31 expression expression NN cord-267001-csgmc155 320 32 of of IN cord-267001-csgmc155 320 33 a a DT cord-267001-csgmc155 320 34 MERS MERS NNP cord-267001-csgmc155 320 35 - - HYPH cord-267001-csgmc155 320 36 coronavirus coronavirus NN cord-267001-csgmc155 320 37 vaccine vaccine NN cord-267001-csgmc155 320 38 antigen antigen NN cord-267001-csgmc155 320 39 Rot Rot NNP cord-267001-csgmc155 320 40 , , , cord-267001-csgmc155 320 41 A. A. NNP cord-267001-csgmc155 320 42 CCR7 CCR7 NNP cord-267001-csgmc155 320 43 and and CC cord-267001-csgmc155 320 44 its -PRON- PRP$ cord-267001-csgmc155 320 45 ligands ligand NNS cord-267001-csgmc155 320 46 : : : cord-267001-csgmc155 320 47 Balancing balance VBG cord-267001-csgmc155 320 48 immunity immunity NN cord-267001-csgmc155 320 49 and and CC cord-267001-csgmc155 320 50 tolerance tolerance NN cord-267001-csgmc155 320 51 Impact Impact NNP cord-267001-csgmc155 320 52 of of IN cord-267001-csgmc155 320 53 CCR7 CCR7 NNP cord-267001-csgmc155 320 54 on on IN cord-267001-csgmc155 320 55 priming priming NN cord-267001-csgmc155 320 56 and and CC cord-267001-csgmc155 320 57 distribution distribution NN cord-267001-csgmc155 320 58 of of IN cord-267001-csgmc155 320 59 antiviral antiviral JJ cord-267001-csgmc155 320 60 effector effector NN cord-267001-csgmc155 320 61 and and CC cord-267001-csgmc155 320 62 memory memory NN cord-267001-csgmc155 320 63 CTL CTL NNP cord-267001-csgmc155 320 64 Antiviral Antiviral NNP cord-267001-csgmc155 320 65 immune immune JJ cord-267001-csgmc155 320 66 responses response NNS cord-267001-csgmc155 320 67 in in IN cord-267001-csgmc155 320 68 the the DT cord-267001-csgmc155 320 69 absence absence NN cord-267001-csgmc155 320 70 of of IN cord-267001-csgmc155 320 71 organized organize VBN cord-267001-csgmc155 320 72 lymphoid lymphoid JJ cord-267001-csgmc155 320 73 T T NNP cord-267001-csgmc155 320 74 cell cell NN cord-267001-csgmc155 320 75 zones zone NNS cord-267001-csgmc155 320 76 in in IN cord-267001-csgmc155 320 77 plt plt NNP cord-267001-csgmc155 320 78 / / SYM cord-267001-csgmc155 320 79 plt plt NNP cord-267001-csgmc155 320 80 mice mouse NNS cord-267001-csgmc155 321 1 The the DT cord-267001-csgmc155 321 2 adjuvant adjuvant JJ cord-267001-csgmc155 321 3 GLA GLA NNP cord-267001-csgmc155 321 4 - - HYPH cord-267001-csgmc155 321 5 SE SE NNP cord-267001-csgmc155 321 6 promotes promote VBZ cord-267001-csgmc155 321 7 human human JJ cord-267001-csgmc155 321 8 Tfh Tfh NNP cord-267001-csgmc155 321 9 cell cell NN cord-267001-csgmc155 321 10 expansion expansion NN cord-267001-csgmc155 321 11 and and CC cord-267001-csgmc155 321 12 emergence emergence NN cord-267001-csgmc155 321 13 of of IN cord-267001-csgmc155 321 14 public public JJ cord-267001-csgmc155 321 15 TCRbeta tcrbeta NN cord-267001-csgmc155 321 16 clonotypes clonotype NNS cord-267001-csgmc155 321 17 Can Can MD cord-267001-csgmc155 321 18 follicular follicular JJ cord-267001-csgmc155 321 19 helper helper NN cord-267001-csgmc155 321 20 T t NN cord-267001-csgmc155 321 21 cells cell NNS cord-267001-csgmc155 321 22 be be VB cord-267001-csgmc155 321 23 targeted target VBN cord-267001-csgmc155 321 24 to to TO cord-267001-csgmc155 321 25 improve improve VB cord-267001-csgmc155 321 26 vaccine vaccine NN cord-267001-csgmc155 321 27 efficacy efficacy NN cord-267001-csgmc155 321 28 ? ? . cord-267001-csgmc155 322 1 A a DT cord-267001-csgmc155 322 2 unique unique JJ cord-267001-csgmc155 322 3 combination combination NN cord-267001-csgmc155 322 4 adjuvant adjuvant NN cord-267001-csgmc155 322 5 modulates modulate VBZ cord-267001-csgmc155 322 6 immune immune JJ cord-267001-csgmc155 322 7 responses response NNS cord-267001-csgmc155 322 8 preventing prevent VBG cord-267001-csgmc155 322 9 vaccine vaccine NN cord-267001-csgmc155 322 10 - - HYPH cord-267001-csgmc155 322 11 enhanced enhance VBN cord-267001-csgmc155 322 12 pulmonary pulmonary JJ cord-267001-csgmc155 322 13 histopathology histopathology NN cord-267001-csgmc155 322 14 after after IN cord-267001-csgmc155 322 15 a a DT cord-267001-csgmc155 322 16 single single JJ cord-267001-csgmc155 322 17 dose dose NN cord-267001-csgmc155 322 18 vaccination vaccination NN cord-267001-csgmc155 322 19 with with IN cord-267001-csgmc155 322 20 fusion fusion NN cord-267001-csgmc155 322 21 protein protein NN cord-267001-csgmc155 322 22 and and CC cord-267001-csgmc155 322 23 challenge challenge NN cord-267001-csgmc155 322 24 with with IN cord-267001-csgmc155 322 25 respiratory respiratory JJ cord-267001-csgmc155 322 26 syncytial syncytial JJ cord-267001-csgmc155 322 27 virus virus NN cord-267001-csgmc155 323 1 This this DT cord-267001-csgmc155 323 2 article article NN cord-267001-csgmc155 323 3 is be VBZ cord-267001-csgmc155 323 4 an an DT cord-267001-csgmc155 323 5 open open JJ cord-267001-csgmc155 323 6 access access NN cord-267001-csgmc155 323 7 article article NN cord-267001-csgmc155 323 8 distributed distribute VBN cord-267001-csgmc155 323 9 under under IN cord-267001-csgmc155 323 10 the the DT cord-267001-csgmc155 323 11 terms term NNS cord-267001-csgmc155 323 12 and and CC cord-267001-csgmc155 323 13 conditions condition NNS cord-267001-csgmc155 323 14 of of IN cord-267001-csgmc155 323 15 the the DT cord-267001-csgmc155 323 16 Creative Creative NNP cord-267001-csgmc155 323 17 Commons Commons NNP cord-267001-csgmc155 323 18 Attribution Attribution NNP cord-267001-csgmc155 323 19 ( ( -LRB- cord-267001-csgmc155 323 20 CC CC NNP cord-267001-csgmc155 323 21 BY by IN cord-267001-csgmc155 323 22 ) ) -RRB- cord-267001-csgmc155 323 23 license license NN cord-267001-csgmc155 323 24 We -PRON- PRP cord-267001-csgmc155 323 25 gratefully gratefully RB cord-267001-csgmc155 323 26 acknowledge acknowledge VBP cord-267001-csgmc155 323 27 Kathy Kathy NNP cord-267001-csgmc155 323 28 Tang Tang NNP cord-267001-csgmc155 323 29 , , , cord-267001-csgmc155 323 30 Head Head NNP cord-267001-csgmc155 323 31 of of IN cord-267001-csgmc155 323 32 the the DT cord-267001-csgmc155 323 33 LARS LARS NNP cord-267001-csgmc155 323 34 facility facility NN cord-267001-csgmc155 323 35 at at IN cord-267001-csgmc155 323 36 NYBC NYBC NNP cord-267001-csgmc155 323 37 for for IN cord-267001-csgmc155 323 38 providing provide VBG cord-267001-csgmc155 323 39 animal animal NN cord-267001-csgmc155 323 40 and and CC cord-267001-csgmc155 323 41 veterinary veterinary JJ cord-267001-csgmc155 323 42 care care NN cord-267001-csgmc155 323 43 . . . cord-267001-csgmc155 324 1 The the DT cord-267001-csgmc155 324 2 authors author NNS cord-267001-csgmc155 324 3 also also RB cord-267001-csgmc155 324 4 thank thank VBP cord-267001-csgmc155 324 5 Mihaela Mihaela NNP cord-267001-csgmc155 324 6 Barbu Barbu NNP cord-267001-csgmc155 324 7 - - HYPH cord-267001-csgmc155 324 8 Stevanovic Stevanovic NNP cord-267001-csgmc155 324 9 , , , cord-267001-csgmc155 324 10 Head Head NNP cord-267001-csgmc155 324 11 of of IN cord-267001-csgmc155 324 12 the the DT cord-267001-csgmc155 324 13 Flowcytometry Flowcytometry NNP cord-267001-csgmc155 324 14 Core Core NNP cord-267001-csgmc155 324 15 facility facility NN cord-267001-csgmc155 324 16 at at IN cord-267001-csgmc155 324 17 NYBC NYBC NNP cord-267001-csgmc155 324 18 . . . cord-267001-csgmc155 325 1 The the DT cord-267001-csgmc155 325 2 authors author NNS cord-267001-csgmc155 325 3 also also RB cord-267001-csgmc155 325 4 acknowledge acknowledge VBP cord-267001-csgmc155 325 5 Maria Maria NNP cord-267001-csgmc155 325 6 Elena Elena NNP cord-267001-csgmc155 325 7 Bottazzi Bottazzi NNP cord-267001-csgmc155 325 8 and and CC cord-267001-csgmc155 325 9 Bin Bin NNP cord-267001-csgmc155 325 10 Zhan Zhan NNP cord-267001-csgmc155 325 11 from from IN cord-267001-csgmc155 325 12 Baylor Baylor NNP cord-267001-csgmc155 325 13 College College NNP cord-267001-csgmc155 325 14 of of IN cord-267001-csgmc155 325 15 Medicine Medicine NNP cord-267001-csgmc155 325 16 , , , cord-267001-csgmc155 325 17 Texas Texas NNP cord-267001-csgmc155 325 18 Children Children NNP cord-267001-csgmc155 325 19 's 's POS cord-267001-csgmc155 325 20 Hospital Hospital NNP cord-267001-csgmc155 325 21 Center Center NNP cord-267001-csgmc155 325 22 for for IN cord-267001-csgmc155 325 23 Vaccine Vaccine NNP cord-267001-csgmc155 325 24 Development Development NNP cord-267001-csgmc155 325 25 , , , cord-267001-csgmc155 325 26 Houston Houston NNP cord-267001-csgmc155 325 27 , , , cord-267001-csgmc155 325 28 Texas Texas NNP cord-267001-csgmc155 325 29 for for IN cord-267001-csgmc155 325 30 the the DT cord-267001-csgmc155 325 31 production production NN cord-267001-csgmc155 325 32 of of IN cord-267001-csgmc155 325 33 the the DT cord-267001-csgmc155 325 34 recombinant recombinant JJ cord-267001-csgmc155 325 35 Ov Ov NNP cord-267001-csgmc155 325 36 - - HYPH cord-267001-csgmc155 325 37 ASP-1 ASP-1 NNP cord-267001-csgmc155 325 38 protein protein NN cord-267001-csgmc155 325 39 . . . cord-267001-csgmc155 326 1 The the DT cord-267001-csgmc155 326 2 authors author NNS cord-267001-csgmc155 326 3 declare declare VBP cord-267001-csgmc155 326 4 no no DT cord-267001-csgmc155 326 5 conflict conflict NN cord-267001-csgmc155 326 6 of of IN cord-267001-csgmc155 326 7 interest interest NN cord-267001-csgmc155 326 8 . . . cord-267001-csgmc155 327 1 The the DT cord-267001-csgmc155 327 2 funders funder NNS cord-267001-csgmc155 327 3 had have VBD cord-267001-csgmc155 327 4 no no DT cord-267001-csgmc155 327 5 role role NN cord-267001-csgmc155 327 6 in in IN cord-267001-csgmc155 327 7 the the DT cord-267001-csgmc155 327 8 design design NN cord-267001-csgmc155 327 9 of of IN cord-267001-csgmc155 327 10 the the DT cord-267001-csgmc155 327 11 study study NN cord-267001-csgmc155 327 12 ; ; : cord-267001-csgmc155 327 13 in in IN cord-267001-csgmc155 327 14 the the DT cord-267001-csgmc155 327 15 collection collection NN cord-267001-csgmc155 327 16 , , , cord-267001-csgmc155 327 17 analyses analysis NNS cord-267001-csgmc155 327 18 , , , cord-267001-csgmc155 327 19 or or CC cord-267001-csgmc155 327 20 interpretation interpretation NN cord-267001-csgmc155 327 21 of of IN cord-267001-csgmc155 327 22 data datum NNS cord-267001-csgmc155 327 23 ; ; : cord-267001-csgmc155 327 24 in in IN cord-267001-csgmc155 327 25 the the DT cord-267001-csgmc155 327 26 writing writing NN cord-267001-csgmc155 327 27 of of IN cord-267001-csgmc155 327 28 the the DT cord-267001-csgmc155 327 29 manuscript manuscript NN cord-267001-csgmc155 327 30 , , , cord-267001-csgmc155 327 31 or or CC cord-267001-csgmc155 327 32 in in IN cord-267001-csgmc155 327 33 the the DT cord-267001-csgmc155 327 34 decision decision NN cord-267001-csgmc155 327 35 to to TO cord-267001-csgmc155 327 36 publish publish VB cord-267001-csgmc155 327 37 the the DT cord-267001-csgmc155 327 38 results result NNS cord-267001-csgmc155 327 39 . . .