id sid tid token lemma pos cord-265279-0zjpqnqp 1 1 key key JJ cord-265279-0zjpqnqp 1 2 : : : cord-265279-0zjpqnqp 1 3 cord-265279 cord-265279 NNP cord-265279-0zjpqnqp 1 4 - - HYPH cord-265279-0zjpqnqp 1 5 0zjpqnqp 0zjpqnqp CD cord-265279-0zjpqnqp 1 6 authors author NNS cord-265279-0zjpqnqp 1 7 : : : cord-265279-0zjpqnqp 1 8 Hoteit Hoteit NNP cord-265279-0zjpqnqp 1 9 , , , cord-265279-0zjpqnqp 1 10 Rouba Rouba NNP cord-265279-0zjpqnqp 1 11 ; ; : cord-265279-0zjpqnqp 1 12 Shammaa Shammaa NNP cord-265279-0zjpqnqp 1 13 , , , cord-265279-0zjpqnqp 1 14 Dina Dina NNP cord-265279-0zjpqnqp 1 15 ; ; : cord-265279-0zjpqnqp 1 16 Mahfouz Mahfouz NNP cord-265279-0zjpqnqp 1 17 , , , cord-265279-0zjpqnqp 1 18 Rami Rami NNP cord-265279-0zjpqnqp 1 19 title title NN cord-265279-0zjpqnqp 1 20 : : : cord-265279-0zjpqnqp 1 21 Use Use NNP cord-265279-0zjpqnqp 1 22 of of IN cord-265279-0zjpqnqp 1 23 the the DT cord-265279-0zjpqnqp 1 24 Human Human NNP cord-265279-0zjpqnqp 1 25 Coronavirus Coronavirus NNP cord-265279-0zjpqnqp 1 26 2012 2012 CD cord-265279-0zjpqnqp 1 27 ( ( -LRB- cord-265279-0zjpqnqp 1 28 MERS MERS NNP cord-265279-0zjpqnqp 1 29 ) ) -RRB- cord-265279-0zjpqnqp 2 1 GeneSig GeneSig NNP cord-265279-0zjpqnqp 2 2 kit kit NN cord-265279-0zjpqnqp 2 3 for for IN cord-265279-0zjpqnqp 2 4 MERS MERS NNP cord-265279-0zjpqnqp 2 5 - - HYPH cord-265279-0zjpqnqp 2 6 CoV CoV NNP cord-265279-0zjpqnqp 2 7 detection detection NN cord-265279-0zjpqnqp 2 8 date date NN cord-265279-0zjpqnqp 2 9 : : : cord-265279-0zjpqnqp 2 10 2016 2016 CD cord-265279-0zjpqnqp 2 11 - - HYPH cord-265279-0zjpqnqp 2 12 04 04 CD cord-265279-0zjpqnqp 2 13 - - SYM cord-265279-0zjpqnqp 2 14 16 16 CD cord-265279-0zjpqnqp 2 15 journal journal NN cord-265279-0zjpqnqp 2 16 : : : cord-265279-0zjpqnqp 3 1 Gene Gene NNP cord-265279-0zjpqnqp 3 2 Rep Rep NNP cord-265279-0zjpqnqp 3 3 DOI DOI NNP cord-265279-0zjpqnqp 3 4 : : : cord-265279-0zjpqnqp 4 1 10.1016 10.1016 LS cord-265279-0zjpqnqp 4 2 / / SYM cord-265279-0zjpqnqp 4 3 j.genrep.2016.04.004 j.genrep.2016.04.004 NNP cord-265279-0zjpqnqp 4 4 sha sha XX cord-265279-0zjpqnqp 4 5 : : : cord-265279-0zjpqnqp 5 1 2dee7034f6900389a04b7cfcc8b9bcdd32175d02 2dee7034f6900389a04b7cfcc8b9bcdd32175d02 CD cord-265279-0zjpqnqp 5 2 doc_id doc_id CD cord-265279-0zjpqnqp 5 3 : : : cord-265279-0zjpqnqp 5 4 265279 265279 CD cord-265279-0zjpqnqp 5 5 cord_uid cord_uid NNS cord-265279-0zjpqnqp 5 6 : : : cord-265279-0zjpqnqp 6 1 0zjpqnqp 0zjpqnqp NFP cord-265279-0zjpqnqp 7 1 INTRODUCTION introduction NN cord-265279-0zjpqnqp 7 2 : : : cord-265279-0zjpqnqp 8 1 Mortality mortality NN cord-265279-0zjpqnqp 8 2 due due IN cord-265279-0zjpqnqp 8 3 to to IN cord-265279-0zjpqnqp 8 4 MERS MERS NNP cord-265279-0zjpqnqp 8 5 - - HYPH cord-265279-0zjpqnqp 8 6 CoV cov NN cord-265279-0zjpqnqp 8 7 infection infection NN cord-265279-0zjpqnqp 8 8 is be VBZ cord-265279-0zjpqnqp 8 9 common common JJ cord-265279-0zjpqnqp 8 10 especially especially RB cord-265279-0zjpqnqp 8 11 among among IN cord-265279-0zjpqnqp 8 12 immunocompromised immunocompromised JJ cord-265279-0zjpqnqp 8 13 patients patient NNS cord-265279-0zjpqnqp 8 14 . . . cord-265279-0zjpqnqp 9 1 The the DT cord-265279-0zjpqnqp 9 2 pathogenesis pathogenesis NN cord-265279-0zjpqnqp 9 3 and and CC cord-265279-0zjpqnqp 9 4 the the DT cord-265279-0zjpqnqp 9 5 transmission transmission NN cord-265279-0zjpqnqp 9 6 mode mode NN cord-265279-0zjpqnqp 9 7 of of IN cord-265279-0zjpqnqp 9 8 this this DT cord-265279-0zjpqnqp 9 9 virus virus NN cord-265279-0zjpqnqp 9 10 are be VBP cord-265279-0zjpqnqp 9 11 still still RB cord-265279-0zjpqnqp 9 12 not not RB cord-265279-0zjpqnqp 9 13 well well RB cord-265279-0zjpqnqp 9 14 understood understand VBN cord-265279-0zjpqnqp 9 15 . . . cord-265279-0zjpqnqp 10 1 The the DT cord-265279-0zjpqnqp 10 2 name name NN cord-265279-0zjpqnqp 10 3 of of IN cord-265279-0zjpqnqp 10 4 the the DT cord-265279-0zjpqnqp 10 5 virus virus NN cord-265279-0zjpqnqp 10 6 is be VBZ cord-265279-0zjpqnqp 10 7 derived derive VBN cord-265279-0zjpqnqp 10 8 from from IN cord-265279-0zjpqnqp 10 9 the the DT cord-265279-0zjpqnqp 10 10 area area NN cord-265279-0zjpqnqp 10 11 of of IN cord-265279-0zjpqnqp 10 12 its -PRON- PRP$ cord-265279-0zjpqnqp 10 13 appearance appearance NN cord-265279-0zjpqnqp 10 14 and and CC cord-265279-0zjpqnqp 10 15 the the DT cord-265279-0zjpqnqp 10 16 genomic genomic JJ cord-265279-0zjpqnqp 10 17 sequence sequence NN cord-265279-0zjpqnqp 10 18 that that WDT cord-265279-0zjpqnqp 10 19 was be VBD cord-265279-0zjpqnqp 10 20 used use VBN cord-265279-0zjpqnqp 10 21 in in IN cord-265279-0zjpqnqp 10 22 the the DT cord-265279-0zjpqnqp 10 23 development development NN cord-265279-0zjpqnqp 10 24 of of IN cord-265279-0zjpqnqp 10 25 qRT qRT NNP cord-265279-0zjpqnqp 10 26 - - HYPH cord-265279-0zjpqnqp 10 27 PCR PCR NNP cord-265279-0zjpqnqp 10 28 assays assay NNS cord-265279-0zjpqnqp 10 29 for for IN cord-265279-0zjpqnqp 10 30 MERS MERS NNP cord-265279-0zjpqnqp 10 31 - - HYPH cord-265279-0zjpqnqp 10 32 CoV CoV NNP cord-265279-0zjpqnqp 10 33 detection detection NN cord-265279-0zjpqnqp 10 34 was be VBD cord-265279-0zjpqnqp 10 35 retrieved retrieve VBN cord-265279-0zjpqnqp 10 36 from from IN cord-265279-0zjpqnqp 10 37 the the DT cord-265279-0zjpqnqp 10 38 first first JJ cord-265279-0zjpqnqp 10 39 detected detect VBN cord-265279-0zjpqnqp 10 40 case case NN cord-265279-0zjpqnqp 10 41 isolate isolate VB cord-265279-0zjpqnqp 10 42 . . . cord-265279-0zjpqnqp 11 1 The the DT cord-265279-0zjpqnqp 11 2 employed employ VBN cord-265279-0zjpqnqp 11 3 assays assay NNS cord-265279-0zjpqnqp 11 4 target target VBP cord-265279-0zjpqnqp 11 5 various various JJ cord-265279-0zjpqnqp 11 6 regions region NNS cord-265279-0zjpqnqp 11 7 including include VBG cord-265279-0zjpqnqp 11 8 the the DT cord-265279-0zjpqnqp 11 9 area area NN cord-265279-0zjpqnqp 11 10 upstream upstream RB cord-265279-0zjpqnqp 11 11 of of IN cord-265279-0zjpqnqp 11 12 the the DT cord-265279-0zjpqnqp 11 13 envelope envelope NN cord-265279-0zjpqnqp 11 14 gene gene NN cord-265279-0zjpqnqp 11 15 ( ( -LRB- cord-265279-0zjpqnqp 11 16 upE upE NNP cord-265279-0zjpqnqp 11 17 ) ) -RRB- cord-265279-0zjpqnqp 11 18 that that WDT cord-265279-0zjpqnqp 11 19 is be VBZ cord-265279-0zjpqnqp 11 20 used use VBN cord-265279-0zjpqnqp 11 21 for for IN cord-265279-0zjpqnqp 11 22 screening screening NN cord-265279-0zjpqnqp 11 23 and and CC cord-265279-0zjpqnqp 11 24 the the DT cord-265279-0zjpqnqp 11 25 open open JJ cord-265279-0zjpqnqp 11 26 reading reading NN cord-265279-0zjpqnqp 11 27 frames frame NNS cord-265279-0zjpqnqp 11 28 ( ( -LRB- cord-265279-0zjpqnqp 11 29 ORF ORF NNP cord-265279-0zjpqnqp 11 30 ) ) -RRB- cord-265279-0zjpqnqp 11 31 1a 1a NN cord-265279-0zjpqnqp 11 32 and and CC cord-265279-0zjpqnqp 11 33 1b 1b CD cord-265279-0zjpqnqp 11 34 used use VBN cord-265279-0zjpqnqp 11 35 for for IN cord-265279-0zjpqnqp 11 36 confirmation confirmation NN cord-265279-0zjpqnqp 11 37 . . . cord-265279-0zjpqnqp 12 1 AIM aim VB cord-265279-0zjpqnqp 12 2 : : : cord-265279-0zjpqnqp 13 1 This this DT cord-265279-0zjpqnqp 13 2 study study NN cord-265279-0zjpqnqp 13 3 assesses assess VBZ cord-265279-0zjpqnqp 13 4 the the DT cord-265279-0zjpqnqp 13 5 use use NN cord-265279-0zjpqnqp 13 6 of of IN cord-265279-0zjpqnqp 13 7 a a DT cord-265279-0zjpqnqp 13 8 MERS MERS NNP cord-265279-0zjpqnqp 13 9 - - HYPH cord-265279-0zjpqnqp 13 10 CoV cov NN cord-265279-0zjpqnqp 13 11 specific specific JJ cord-265279-0zjpqnqp 13 12 assay assay NN cord-265279-0zjpqnqp 13 13 for for IN cord-265279-0zjpqnqp 13 14 screening screening NN cord-265279-0zjpqnqp 13 15 of of IN cord-265279-0zjpqnqp 13 16 respiratory respiratory JJ cord-265279-0zjpqnqp 13 17 samples sample NNS cord-265279-0zjpqnqp 13 18 in in IN cord-265279-0zjpqnqp 13 19 anticipation anticipation NN cord-265279-0zjpqnqp 13 20 of of IN cord-265279-0zjpqnqp 13 21 the the DT cord-265279-0zjpqnqp 13 22 possible possible JJ cord-265279-0zjpqnqp 13 23 spread spread NN cord-265279-0zjpqnqp 13 24 of of IN cord-265279-0zjpqnqp 13 25 the the DT cord-265279-0zjpqnqp 13 26 virus virus NN cord-265279-0zjpqnqp 13 27 in in IN cord-265279-0zjpqnqp 13 28 the the DT cord-265279-0zjpqnqp 13 29 region region NN cord-265279-0zjpqnqp 13 30 . . . cord-265279-0zjpqnqp 14 1 METHODS methods NN cord-265279-0zjpqnqp 14 2 : : : cord-265279-0zjpqnqp 15 1 46 46 CD cord-265279-0zjpqnqp 15 2 respiratory respiratory JJ cord-265279-0zjpqnqp 15 3 specimens specimen NNS cord-265279-0zjpqnqp 15 4 were be VBD cord-265279-0zjpqnqp 15 5 tested test VBN cord-265279-0zjpqnqp 15 6 using use VBG cord-265279-0zjpqnqp 15 7 the the DT cord-265279-0zjpqnqp 15 8 qualitative qualitative JJ cord-265279-0zjpqnqp 15 9 one one CD cord-265279-0zjpqnqp 15 10 - - HYPH cord-265279-0zjpqnqp 15 11 step step NN cord-265279-0zjpqnqp 15 12 qRT qrt ADD cord-265279-0zjpqnqp 15 13 - - HYPH cord-265279-0zjpqnqp 15 14 PCR PCR NNP cord-265279-0zjpqnqp 15 15 GeneSig GeneSig NNP cord-265279-0zjpqnqp 15 16 Human Human NNP cord-265279-0zjpqnqp 15 17 Coronavirus Coronavirus NNP cord-265279-0zjpqnqp 15 18 2012 2012 CD cord-265279-0zjpqnqp 15 19 ( ( -LRB- cord-265279-0zjpqnqp 15 20 MERS MERS NNP cord-265279-0zjpqnqp 15 21 ) ) -RRB- cord-265279-0zjpqnqp 15 22 kit kit NN cord-265279-0zjpqnqp 15 23 ( ( -LRB- cord-265279-0zjpqnqp 15 24 PrimerDesign PrimerDesign NNP cord-265279-0zjpqnqp 15 25 ™ ™ NN cord-265279-0zjpqnqp 15 26 ) ) -RRB- cord-265279-0zjpqnqp 15 27 . . . cord-265279-0zjpqnqp 16 1 RESULTS result NNS cord-265279-0zjpqnqp 16 2 : : : cord-265279-0zjpqnqp 17 1 Out out IN cord-265279-0zjpqnqp 17 2 of of IN cord-265279-0zjpqnqp 17 3 the the DT cord-265279-0zjpqnqp 17 4 46 46 CD cord-265279-0zjpqnqp 17 5 tested test VBN cord-265279-0zjpqnqp 17 6 samples sample NNS cord-265279-0zjpqnqp 17 7 , , , cord-265279-0zjpqnqp 17 8 45 45 CD cord-265279-0zjpqnqp 17 9 were be VBD cord-265279-0zjpqnqp 17 10 negative negative JJ cord-265279-0zjpqnqp 17 11 for for IN cord-265279-0zjpqnqp 17 12 MERS MERS NNP cord-265279-0zjpqnqp 17 13 - - HYPH cord-265279-0zjpqnqp 17 14 CoV CoV NNP cord-265279-0zjpqnqp 17 15 and and CC cord-265279-0zjpqnqp 17 16 one one CD cord-265279-0zjpqnqp 17 17 sample sample NN cord-265279-0zjpqnqp 17 18 was be VBD cord-265279-0zjpqnqp 17 19 found find VBN cord-265279-0zjpqnqp 17 20 MERS MERS NNP cord-265279-0zjpqnqp 17 21 - - HYPH cord-265279-0zjpqnqp 17 22 CoV CoV NNP cord-265279-0zjpqnqp 17 23 positive positive JJ cord-265279-0zjpqnqp 17 24 . . . cord-265279-0zjpqnqp 18 1 CONCLUSION conclusion NN cord-265279-0zjpqnqp 18 2 : : : cord-265279-0zjpqnqp 19 1 The the DT cord-265279-0zjpqnqp 19 2 GeneSig GeneSig NNP cord-265279-0zjpqnqp 19 3 Human Human NNP cord-265279-0zjpqnqp 19 4 Coronavirus Coronavirus NNP cord-265279-0zjpqnqp 19 5 2012 2012 CD cord-265279-0zjpqnqp 19 6 ( ( -LRB- cord-265279-0zjpqnqp 19 7 MERS MERS NNP cord-265279-0zjpqnqp 19 8 ) ) -RRB- cord-265279-0zjpqnqp 19 9 kit kit NN cord-265279-0zjpqnqp 19 10 is be VBZ cord-265279-0zjpqnqp 19 11 very very RB cord-265279-0zjpqnqp 19 12 useful useful JJ cord-265279-0zjpqnqp 19 13 for for IN cord-265279-0zjpqnqp 19 14 the the DT cord-265279-0zjpqnqp 19 15 screening screening NN cord-265279-0zjpqnqp 19 16 of of IN cord-265279-0zjpqnqp 19 17 suspected suspect VBN cord-265279-0zjpqnqp 19 18 respiratory respiratory JJ cord-265279-0zjpqnqp 19 19 cases case NNS cord-265279-0zjpqnqp 19 20 in in IN cord-265279-0zjpqnqp 19 21 the the DT cord-265279-0zjpqnqp 19 22 Middle Middle NNP cord-265279-0zjpqnqp 19 23 East East NNP cord-265279-0zjpqnqp 19 24 area area NN cord-265279-0zjpqnqp 19 25 as as RB cord-265279-0zjpqnqp 19 26 well well RB cord-265279-0zjpqnqp 19 27 as as IN cord-265279-0zjpqnqp 19 28 other other JJ cord-265279-0zjpqnqp 19 29 regions region NNS cord-265279-0zjpqnqp 19 30 . . . cord-265279-0zjpqnqp 20 1 The the DT cord-265279-0zjpqnqp 20 2 Middle Middle NNP cord-265279-0zjpqnqp 20 3 East East NNP cord-265279-0zjpqnqp 20 4 Respiratory Respiratory NNP cord-265279-0zjpqnqp 20 5 Syndrome Syndrome NNP cord-265279-0zjpqnqp 20 6 ( ( -LRB- cord-265279-0zjpqnqp 20 7 MERS MERS NNP cord-265279-0zjpqnqp 20 8 ) ) -RRB- cord-265279-0zjpqnqp 20 9 is be VBZ cord-265279-0zjpqnqp 20 10 a a DT cord-265279-0zjpqnqp 20 11 novel novel JJ cord-265279-0zjpqnqp 20 12 Coronavirus Coronavirus NNP cord-265279-0zjpqnqp 20 13 first first RB cord-265279-0zjpqnqp 20 14 discovered discover VBD cord-265279-0zjpqnqp 20 15 in in IN cord-265279-0zjpqnqp 20 16 September September NNP cord-265279-0zjpqnqp 20 17 2012 2012 CD cord-265279-0zjpqnqp 20 18 in in IN cord-265279-0zjpqnqp 20 19 a a DT cord-265279-0zjpqnqp 20 20 cell cell NN cord-265279-0zjpqnqp 20 21 - - HYPH cord-265279-0zjpqnqp 20 22 culture culture NN cord-265279-0zjpqnqp 20 23 from from IN cord-265279-0zjpqnqp 20 24 a a DT cord-265279-0zjpqnqp 20 25 patient patient NN cord-265279-0zjpqnqp 20 26 after after IN cord-265279-0zjpqnqp 20 27 his -PRON- PRP$ cord-265279-0zjpqnqp 20 28 death death NN cord-265279-0zjpqnqp 20 29 from from IN cord-265279-0zjpqnqp 20 30 pneumonia pneumonia NN cord-265279-0zjpqnqp 20 31 in in IN cord-265279-0zjpqnqp 20 32 June June NNP cord-265279-0zjpqnqp 20 33 2012 2012 CD cord-265279-0zjpqnqp 20 34 in in IN cord-265279-0zjpqnqp 20 35 Saudi Saudi NNP cord-265279-0zjpqnqp 20 36 Arabia Arabia NNP cord-265279-0zjpqnqp 21 1 ( ( -LRB- cord-265279-0zjpqnqp 21 2 Assiri Assiri NNP cord-265279-0zjpqnqp 21 3 et et NNP cord-265279-0zjpqnqp 21 4 al al NNP cord-265279-0zjpqnqp 21 5 . . NNP cord-265279-0zjpqnqp 21 6 , , , cord-265279-0zjpqnqp 21 7 2013 2013 CD cord-265279-0zjpqnqp 21 8 ) ) -RRB- cord-265279-0zjpqnqp 21 9 . . . cord-265279-0zjpqnqp 22 1 Mortality mortality NN cord-265279-0zjpqnqp 22 2 due due IN cord-265279-0zjpqnqp 22 3 to to IN cord-265279-0zjpqnqp 22 4 MERS MERS NNP cord-265279-0zjpqnqp 22 5 - - HYPH cord-265279-0zjpqnqp 22 6 CoV cov NN cord-265279-0zjpqnqp 22 7 infection infection NN cord-265279-0zjpqnqp 22 8 is be VBZ cord-265279-0zjpqnqp 22 9 common common JJ cord-265279-0zjpqnqp 22 10 especially especially RB cord-265279-0zjpqnqp 22 11 among among IN cord-265279-0zjpqnqp 22 12 immunocompromised immunocompromised JJ cord-265279-0zjpqnqp 22 13 patients patient NNS cord-265279-0zjpqnqp 23 1 ( ( -LRB- cord-265279-0zjpqnqp 23 2 Al Al NNP cord-265279-0zjpqnqp 23 3 - - HYPH cord-265279-0zjpqnqp 23 4 Abdallat Abdallat NNP cord-265279-0zjpqnqp 23 5 et et NNP cord-265279-0zjpqnqp 23 6 al al NNP cord-265279-0zjpqnqp 23 7 . . NNP cord-265279-0zjpqnqp 23 8 , , , cord-265279-0zjpqnqp 23 9 2014 2014 CD cord-265279-0zjpqnqp 23 10 ) ) -RRB- cord-265279-0zjpqnqp 23 11 . . . cord-265279-0zjpqnqp 24 1 Coronaviruses coronaviruse NNS cord-265279-0zjpqnqp 24 2 are be VBP cord-265279-0zjpqnqp 24 3 the the DT cord-265279-0zjpqnqp 24 4 largest large JJS cord-265279-0zjpqnqp 24 5 positive positive JJ cord-265279-0zjpqnqp 24 6 single single JJ cord-265279-0zjpqnqp 24 7 - - HYPH cord-265279-0zjpqnqp 24 8 stranded strand VBN cord-265279-0zjpqnqp 24 9 RNA RNA NNP cord-265279-0zjpqnqp 24 10 viruses virus NNS cord-265279-0zjpqnqp 24 11 with with IN cord-265279-0zjpqnqp 24 12 a a DT cord-265279-0zjpqnqp 24 13 genome genome NN cord-265279-0zjpqnqp 24 14 that that WDT cord-265279-0zjpqnqp 24 15 can can MD cord-265279-0zjpqnqp 24 16 reach reach VB cord-265279-0zjpqnqp 24 17 up up IN cord-265279-0zjpqnqp 24 18 to to TO cord-265279-0zjpqnqp 24 19 32 32 CD cord-265279-0zjpqnqp 24 20 kb kb NNP cord-265279-0zjpqnqp 24 21 long long JJ cord-265279-0zjpqnqp 24 22 . . . cord-265279-0zjpqnqp 25 1 The the DT cord-265279-0zjpqnqp 25 2 genome genome NN cord-265279-0zjpqnqp 25 3 entails entail VBZ cord-265279-0zjpqnqp 25 4 a a DT cord-265279-0zjpqnqp 25 5 5′-terminal 5′-terminal CD cord-265279-0zjpqnqp 25 6 cap cap NN cord-265279-0zjpqnqp 25 7 structure structure NN cord-265279-0zjpqnqp 25 8 and and CC cord-265279-0zjpqnqp 25 9 is be VBZ cord-265279-0zjpqnqp 25 10 polyadenylated polyadenylate VBN cord-265279-0zjpqnqp 25 11 at at IN cord-265279-0zjpqnqp 25 12 its -PRON- PRP$ cord-265279-0zjpqnqp 25 13 3′ 3′ CD cord-265279-0zjpqnqp 25 14 end end NN cord-265279-0zjpqnqp 25 15 , , , cord-265279-0zjpqnqp 25 16 and and CC cord-265279-0zjpqnqp 25 17 is be VBZ cord-265279-0zjpqnqp 25 18 occupied occupy VBN cord-265279-0zjpqnqp 25 19 by by IN cord-265279-0zjpqnqp 25 20 two two CD cord-265279-0zjpqnqp 25 21 large large JJ cord-265279-0zjpqnqp 25 22 overlapping overlap VBG cord-265279-0zjpqnqp 25 23 open open JJ cord-265279-0zjpqnqp 25 24 reading reading NN cord-265279-0zjpqnqp 25 25 frames frame NNS cord-265279-0zjpqnqp 25 26 , , , cord-265279-0zjpqnqp 25 27 ORFs ORFs NNP cord-265279-0zjpqnqp 25 28 1a 1a NN cord-265279-0zjpqnqp 25 29 and and CC cord-265279-0zjpqnqp 25 30 1b 1b CD cord-265279-0zjpqnqp 26 1 ( ( -LRB- cord-265279-0zjpqnqp 26 2 Subissi Subissi NNP cord-265279-0zjpqnqp 26 3 et et NNP cord-265279-0zjpqnqp 26 4 al al NNP cord-265279-0zjpqnqp 26 5 . . NNP cord-265279-0zjpqnqp 26 6 , , , cord-265279-0zjpqnqp 26 7 2014 2014 CD cord-265279-0zjpqnqp 26 8 ) ) -RRB- cord-265279-0zjpqnqp 26 9 . . . cord-265279-0zjpqnqp 27 1 MERS MERS NNP cord-265279-0zjpqnqp 27 2 - - HYPH cord-265279-0zjpqnqp 27 3 CoV CoV NNP cord-265279-0zjpqnqp 27 4 is be VBZ cord-265279-0zjpqnqp 27 5 part part NN cord-265279-0zjpqnqp 27 6 of of IN cord-265279-0zjpqnqp 27 7 the the DT cord-265279-0zjpqnqp 27 8 C C NNP cord-265279-0zjpqnqp 27 9 lineage lineage NN cord-265279-0zjpqnqp 27 10 of of IN cord-265279-0zjpqnqp 27 11 the the DT cord-265279-0zjpqnqp 27 12 Betacoronavirus Betacoronavirus NNP cord-265279-0zjpqnqp 27 13 genus genus NN cord-265279-0zjpqnqp 28 1 and and CC cord-265279-0zjpqnqp 28 2 it -PRON- PRP cord-265279-0zjpqnqp 28 3 is be VBZ cord-265279-0zjpqnqp 28 4 related relate VBN cord-265279-0zjpqnqp 28 5 to to IN cord-265279-0zjpqnqp 28 6 the the DT cord-265279-0zjpqnqp 28 7 HKU4 HKU4 NNP cord-265279-0zjpqnqp 28 8 and and CC cord-265279-0zjpqnqp 28 9 HKU5 HKU5 NNP cord-265279-0zjpqnqp 28 10 coronavirus coronavirus NN cord-265279-0zjpqnqp 28 11 detected detect VBN cord-265279-0zjpqnqp 28 12 in in IN cord-265279-0zjpqnqp 28 13 bats bat NNS cord-265279-0zjpqnqp 28 14 ( ( -LRB- cord-265279-0zjpqnqp 28 15 Omrani Omrani NNP cord-265279-0zjpqnqp 28 16 et et NNP cord-265279-0zjpqnqp 28 17 al al NNP cord-265279-0zjpqnqp 28 18 . . . cord-265279-0zjpqnqp 29 1 , , , cord-265279-0zjpqnqp 29 2 2013 2013 CD cord-265279-0zjpqnqp 29 3 ) ) -RRB- cord-265279-0zjpqnqp 29 4 . . . cord-265279-0zjpqnqp 30 1 MERS MERS NNP cord-265279-0zjpqnqp 30 2 - - HYPH cord-265279-0zjpqnqp 30 3 CoV CoV NNP cord-265279-0zjpqnqp 30 4 and and CC cord-265279-0zjpqnqp 30 5 highly highly RB cord-265279-0zjpqnqp 30 6 homologous homologous JJ cord-265279-0zjpqnqp 31 1 MERS MERS NNP cord-265279-0zjpqnqp 31 2 - - HYPH cord-265279-0zjpqnqp 31 3 like like JJ cord-265279-0zjpqnqp 31 4 CoV CoV NNP cord-265279-0zjpqnqp 31 5 were be VBD cord-265279-0zjpqnqp 31 6 isolated isolate VBN cord-265279-0zjpqnqp 31 7 in in IN cord-265279-0zjpqnqp 31 8 dromedary dromedary NN cord-265279-0zjpqnqp 31 9 camels camel NNS cord-265279-0zjpqnqp 31 10 and and CC cord-265279-0zjpqnqp 31 11 African african JJ cord-265279-0zjpqnqp 31 12 Neoromicia Neoromicia NNP cord-265279-0zjpqnqp 31 13 capensis capensis NN cord-265279-0zjpqnqp 31 14 bats bat NNS cord-265279-0zjpqnqp 31 15 , , , cord-265279-0zjpqnqp 31 16 respectively respectively RB cord-265279-0zjpqnqp 31 17 . . . cord-265279-0zjpqnqp 32 1 Although although IN cord-265279-0zjpqnqp 32 2 MERS MERS NNP cord-265279-0zjpqnqp 32 3 - - HYPH cord-265279-0zjpqnqp 32 4 CoV CoV NNP cord-265279-0zjpqnqp 32 5 is be VBZ cord-265279-0zjpqnqp 32 6 known know VBN cord-265279-0zjpqnqp 32 7 to to TO cord-265279-0zjpqnqp 32 8 have have VB cord-265279-0zjpqnqp 32 9 zoonotic zoonotic JJ cord-265279-0zjpqnqp 32 10 origins origin NNS cord-265279-0zjpqnqp 32 11 the the DT cord-265279-0zjpqnqp 32 12 pathway pathway NN cord-265279-0zjpqnqp 32 13 of of IN cord-265279-0zjpqnqp 32 14 transmission transmission NN cord-265279-0zjpqnqp 32 15 from from IN cord-265279-0zjpqnqp 32 16 the the DT cord-265279-0zjpqnqp 32 17 animal animal NN cord-265279-0zjpqnqp 32 18 reservoir reservoir NN cord-265279-0zjpqnqp 32 19 to to IN cord-265279-0zjpqnqp 32 20 humans human NNS cord-265279-0zjpqnqp 32 21 is be VBZ cord-265279-0zjpqnqp 32 22 still still RB cord-265279-0zjpqnqp 32 23 not not RB cord-265279-0zjpqnqp 32 24 well well RB cord-265279-0zjpqnqp 32 25 understood understand VBN cord-265279-0zjpqnqp 32 26 . . . cord-265279-0zjpqnqp 33 1 It -PRON- PRP cord-265279-0zjpqnqp 33 2 is be VBZ cord-265279-0zjpqnqp 33 3 , , , cord-265279-0zjpqnqp 33 4 however however RB cord-265279-0zjpqnqp 33 5 , , , cord-265279-0zjpqnqp 33 6 suggested suggest VBD cord-265279-0zjpqnqp 33 7 that that IN cord-265279-0zjpqnqp 33 8 a a DT cord-265279-0zjpqnqp 33 9 bat bat NN cord-265279-0zjpqnqp 33 10 to to TO cord-265279-0zjpqnqp 33 11 camel camel VB cord-265279-0zjpqnqp 33 12 to to IN cord-265279-0zjpqnqp 33 13 human human JJ cord-265279-0zjpqnqp 33 14 route route NN cord-265279-0zjpqnqp 33 15 could could MD cord-265279-0zjpqnqp 33 16 explain explain VB cord-265279-0zjpqnqp 33 17 the the DT cord-265279-0zjpqnqp 33 18 MERS MERS NNP cord-265279-0zjpqnqp 33 19 - - HYPH cord-265279-0zjpqnqp 33 20 CoV CoV NNP cord-265279-0zjpqnqp 33 21 2012 2012 CD cord-265279-0zjpqnqp 33 22 outbreak outbreak NN cord-265279-0zjpqnqp 33 23 in in IN cord-265279-0zjpqnqp 33 24 humans human NNS cord-265279-0zjpqnqp 33 25 , , , cord-265279-0zjpqnqp 33 26 due due IN cord-265279-0zjpqnqp 33 27 to to IN cord-265279-0zjpqnqp 33 28 the the DT cord-265279-0zjpqnqp 33 29 emerging emerge VBG cord-265279-0zjpqnqp 33 30 camel camel NN cord-265279-0zjpqnqp 33 31 trade trade NN cord-265279-0zjpqnqp 33 32 between between IN cord-265279-0zjpqnqp 33 33 equatorial equatorial JJ cord-265279-0zjpqnqp 33 34 Africa Africa NNP cord-265279-0zjpqnqp 33 35 and and CC cord-265279-0zjpqnqp 33 36 Saudi Saudi NNP cord-265279-0zjpqnqp 33 37 Arabia Arabia NNP cord-265279-0zjpqnqp 33 38 during during IN cord-265279-0zjpqnqp 33 39 the the DT cord-265279-0zjpqnqp 33 40 last last JJ cord-265279-0zjpqnqp 33 41 20 20 CD cord-265279-0zjpqnqp 33 42 years year NNS cord-265279-0zjpqnqp 34 1 ( ( -LRB- cord-265279-0zjpqnqp 34 2 Gralinski Gralinski NNP cord-265279-0zjpqnqp 34 3 and and CC cord-265279-0zjpqnqp 34 4 Baric Baric NNP cord-265279-0zjpqnqp 34 5 , , , cord-265279-0zjpqnqp 34 6 2015 2015 CD cord-265279-0zjpqnqp 34 7 ) ) -RRB- cord-265279-0zjpqnqp 34 8 . . . cord-265279-0zjpqnqp 35 1 MERS MERS NNP cord-265279-0zjpqnqp 35 2 - - HYPH cord-265279-0zjpqnqp 35 3 CoV CoV NNP cord-265279-0zjpqnqp 35 4 causes cause VBZ cord-265279-0zjpqnqp 35 5 severe severe JJ cord-265279-0zjpqnqp 35 6 lower low JJR cord-265279-0zjpqnqp 35 7 respiratory respiratory JJ cord-265279-0zjpqnqp 35 8 tract tract NN cord-265279-0zjpqnqp 35 9 infection infection NN cord-265279-0zjpqnqp 35 10 that that WDT cord-265279-0zjpqnqp 35 11 sometimes sometimes RB cord-265279-0zjpqnqp 35 12 requires require VBZ cord-265279-0zjpqnqp 35 13 admission admission NN cord-265279-0zjpqnqp 35 14 to to IN cord-265279-0zjpqnqp 35 15 the the DT cord-265279-0zjpqnqp 35 16 intensive intensive JJ cord-265279-0zjpqnqp 35 17 care care NN cord-265279-0zjpqnqp 35 18 unit unit NN cord-265279-0zjpqnqp 35 19 . . . cord-265279-0zjpqnqp 36 1 Patients patient NNS cord-265279-0zjpqnqp 36 2 usually usually RB cord-265279-0zjpqnqp 36 3 respond respond VBP cord-265279-0zjpqnqp 36 4 well well RB cord-265279-0zjpqnqp 36 5 to to IN cord-265279-0zjpqnqp 36 6 alpha alpha NN cord-265279-0zjpqnqp 36 7 interferon interferon NN cord-265279-0zjpqnqp 36 8 or or CC cord-265279-0zjpqnqp 36 9 cyclosporine cyclosporine JJ cord-265279-0zjpqnqp 36 10 treatment treatment NN cord-265279-0zjpqnqp 36 11 , , , cord-265279-0zjpqnqp 36 12 however however RB cord-265279-0zjpqnqp 36 13 , , , cord-265279-0zjpqnqp 36 14 no no DT cord-265279-0zjpqnqp 36 15 specific specific JJ cord-265279-0zjpqnqp 36 16 antiviral antiviral JJ cord-265279-0zjpqnqp 36 17 or or CC cord-265279-0zjpqnqp 36 18 vaccine vaccine NN cord-265279-0zjpqnqp 36 19 is be VBZ cord-265279-0zjpqnqp 36 20 available available JJ cord-265279-0zjpqnqp 36 21 for for IN cord-265279-0zjpqnqp 36 22 MERS MERS NNP cord-265279-0zjpqnqp 36 23 - - HYPH cord-265279-0zjpqnqp 36 24 CoV CoV NNP cord-265279-0zjpqnqp 36 25 ( ( -LRB- cord-265279-0zjpqnqp 36 26 Ohnuma Ohnuma NNP cord-265279-0zjpqnqp 36 27 et et NNP cord-265279-0zjpqnqp 36 28 al al NNP cord-265279-0zjpqnqp 36 29 . . NNP cord-265279-0zjpqnqp 36 30 , , , cord-265279-0zjpqnqp 36 31 2013 2013 CD cord-265279-0zjpqnqp 36 32 ) ) -RRB- cord-265279-0zjpqnqp 36 33 . . . cord-265279-0zjpqnqp 37 1 More More JJR cord-265279-0zjpqnqp 37 2 than than IN cord-265279-0zjpqnqp 37 3 1540 1540 CD cord-265279-0zjpqnqp 37 4 cases case NNS cord-265279-0zjpqnqp 37 5 from from IN cord-265279-0zjpqnqp 37 6 21 21 CD cord-265279-0zjpqnqp 37 7 countries country NNS cord-265279-0zjpqnqp 37 8 worldwide worldwide RB cord-265279-0zjpqnqp 37 9 have have VBP cord-265279-0zjpqnqp 37 10 been be VBN cord-265279-0zjpqnqp 37 11 infected infect VBN cord-265279-0zjpqnqp 37 12 and and CC cord-265279-0zjpqnqp 37 13 diagnosed diagnose VBN cord-265279-0zjpqnqp 37 14 with with IN cord-265279-0zjpqnqp 37 15 MERS MERS NNP cord-265279-0zjpqnqp 37 16 - - HYPH cord-265279-0zjpqnqp 37 17 CoV CoV NNP cord-265279-0zjpqnqp 37 18 since since IN cord-265279-0zjpqnqp 37 19 June June NNP cord-265279-0zjpqnqp 37 20 2012 2012 CD cord-265279-0zjpqnqp 37 21 , , , cord-265279-0zjpqnqp 37 22 and and CC cord-265279-0zjpqnqp 37 23 almost almost RB cord-265279-0zjpqnqp 37 24 a a DT cord-265279-0zjpqnqp 37 25 third third NN cord-265279-0zjpqnqp 37 26 of of IN cord-265279-0zjpqnqp 37 27 those those DT cord-265279-0zjpqnqp 37 28 died die VBN cord-265279-0zjpqnqp 37 29 ( ( -LRB- cord-265279-0zjpqnqp 38 1 Saad Saad NNP cord-265279-0zjpqnqp 38 2 et et NNP cord-265279-0zjpqnqp 38 3 al al NNP cord-265279-0zjpqnqp 38 4 . . NNP cord-265279-0zjpqnqp 38 5 , , , cord-265279-0zjpqnqp 38 6 2014 2014 CD cord-265279-0zjpqnqp 38 7 ; ; : cord-265279-0zjpqnqp 38 8 WHO who WP cord-265279-0zjpqnqp 38 9 , , , cord-265279-0zjpqnqp 38 10 c c NN cord-265279-0zjpqnqp 38 11 2015 2015 CD cord-265279-0zjpqnqp 38 12 ) ) -RRB- cord-265279-0zjpqnqp 38 13 . . . cord-265279-0zjpqnqp 39 1 Patients patient NNS cord-265279-0zjpqnqp 39 2 with with IN cord-265279-0zjpqnqp 39 3 MERS MERS NNP cord-265279-0zjpqnqp 39 4 - - HYPH cord-265279-0zjpqnqp 39 5 CoV cov NN cord-265279-0zjpqnqp 39 6 infection infection NN cord-265279-0zjpqnqp 39 7 tend tend VBP cord-265279-0zjpqnqp 39 8 to to TO cord-265279-0zjpqnqp 39 9 have have VB cord-265279-0zjpqnqp 39 10 leukocytosis leukocytosis NN cord-265279-0zjpqnqp 39 11 , , , cord-265279-0zjpqnqp 39 12 lymphopenia lymphopenia NNP cord-265279-0zjpqnqp 39 13 and and CC cord-265279-0zjpqnqp 39 14 some some DT cord-265279-0zjpqnqp 39 15 express express JJ cord-265279-0zjpqnqp 39 16 thrombocytopenia thrombocytopenia NN cord-265279-0zjpqnqp 39 17 and and CC cord-265279-0zjpqnqp 39 18 coagulopathy coagulopathy NN cord-265279-0zjpqnqp 39 19 . . . cord-265279-0zjpqnqp 40 1 Moreover moreover RB cord-265279-0zjpqnqp 40 2 , , , cord-265279-0zjpqnqp 40 3 creatinine creatinine NN cord-265279-0zjpqnqp 40 4 levels level NNS cord-265279-0zjpqnqp 40 5 , , , cord-265279-0zjpqnqp 40 6 lactate lactate NN cord-265279-0zjpqnqp 40 7 dehydrogenase dehydrogenase NN cord-265279-0zjpqnqp 40 8 , , , cord-265279-0zjpqnqp 40 9 alanine alanine NN cord-265279-0zjpqnqp 40 10 aminotransferase aminotransferase NN cord-265279-0zjpqnqp 40 11 and and CC cord-265279-0zjpqnqp 40 12 aspartate aspartate NN cord-265279-0zjpqnqp 40 13 aminotransferase aminotransferase NN cord-265279-0zjpqnqp 40 14 levels level NNS cord-265279-0zjpqnqp 40 15 may may MD cord-265279-0zjpqnqp 40 16 be be VB cord-265279-0zjpqnqp 40 17 elevated elevate VBN cord-265279-0zjpqnqp 40 18 and and CC cord-265279-0zjpqnqp 40 19 thus thus RB cord-265279-0zjpqnqp 40 20 implying imply VBG cord-265279-0zjpqnqp 40 21 a a DT cord-265279-0zjpqnqp 40 22 liver liver NN cord-265279-0zjpqnqp 40 23 or or CC cord-265279-0zjpqnqp 40 24 kidney kidney NN cord-265279-0zjpqnqp 40 25 disease disease NN cord-265279-0zjpqnqp 40 26 ( ( -LRB- cord-265279-0zjpqnqp 40 27 van van NNP cord-265279-0zjpqnqp 40 28 den den NNP cord-265279-0zjpqnqp 40 29 Brand Brand NNP cord-265279-0zjpqnqp 40 30 et et NNP cord-265279-0zjpqnqp 40 31 al al NNP cord-265279-0zjpqnqp 40 32 . . NNP cord-265279-0zjpqnqp 40 33 , , , cord-265279-0zjpqnqp 40 34 2015 2015 CD cord-265279-0zjpqnqp 40 35 ) ) -RRB- cord-265279-0zjpqnqp 40 36 . . . cord-265279-0zjpqnqp 41 1 Males male NNS cord-265279-0zjpqnqp 41 2 and and CC cord-265279-0zjpqnqp 41 3 elderly elderly JJ cord-265279-0zjpqnqp 41 4 are be VBP cord-265279-0zjpqnqp 41 5 more more RBR cord-265279-0zjpqnqp 41 6 commonly commonly RB cord-265279-0zjpqnqp 41 7 infected infect VBN cord-265279-0zjpqnqp 41 8 with with IN cord-265279-0zjpqnqp 41 9 MERS MERS NNP cord-265279-0zjpqnqp 41 10 - - HYPH cord-265279-0zjpqnqp 41 11 CoV CoV NNP cord-265279-0zjpqnqp 41 12 than than IN cord-265279-0zjpqnqp 41 13 females female NNS cord-265279-0zjpqnqp 41 14 and and CC cord-265279-0zjpqnqp 41 15 younger young JJR cord-265279-0zjpqnqp 41 16 people people NNS cord-265279-0zjpqnqp 41 17 , , , cord-265279-0zjpqnqp 41 18 and and CC cord-265279-0zjpqnqp 41 19 human human NN cord-265279-0zjpqnqp 41 20 - - HYPH cord-265279-0zjpqnqp 41 21 to to IN cord-265279-0zjpqnqp 41 22 - - HYPH cord-265279-0zjpqnqp 41 23 human human JJ cord-265279-0zjpqnqp 41 24 transmission transmission NN cord-265279-0zjpqnqp 41 25 in in IN cord-265279-0zjpqnqp 41 26 the the DT cord-265279-0zjpqnqp 41 27 community community NN cord-265279-0zjpqnqp 41 28 is be VBZ cord-265279-0zjpqnqp 41 29 mainly mainly RB cord-265279-0zjpqnqp 41 30 in in IN cord-265279-0zjpqnqp 41 31 healthcare healthcare NN cord-265279-0zjpqnqp 41 32 settings setting NNS cord-265279-0zjpqnqp 41 33 where where WRB cord-265279-0zjpqnqp 41 34 poor poor JJ cord-265279-0zjpqnqp 41 35 infection infection NN cord-265279-0zjpqnqp 41 36 control control NN cord-265279-0zjpqnqp 41 37 measures measure NNS cord-265279-0zjpqnqp 41 38 are be VBP cord-265279-0zjpqnqp 41 39 implemented implement VBN cord-265279-0zjpqnqp 41 40 especially especially RB cord-265279-0zjpqnqp 41 41 in in IN cord-265279-0zjpqnqp 41 42 intensive intensive JJ cord-265279-0zjpqnqp 41 43 care care NN cord-265279-0zjpqnqp 41 44 units unit NNS cord-265279-0zjpqnqp 41 45 , , , cord-265279-0zjpqnqp 41 46 and and CC cord-265279-0zjpqnqp 41 47 where where WRB cord-265279-0zjpqnqp 41 48 overcrowding overcrowding NN cord-265279-0zjpqnqp 41 49 of of IN cord-265279-0zjpqnqp 41 50 patients patient NNS cord-265279-0zjpqnqp 41 51 may may MD cord-265279-0zjpqnqp 41 52 occur occur VB cord-265279-0zjpqnqp 42 1 ( ( -LRB- cord-265279-0zjpqnqp 42 2 Saad Saad NNP cord-265279-0zjpqnqp 42 3 et et NNP cord-265279-0zjpqnqp 42 4 al al NNP cord-265279-0zjpqnqp 42 5 . . NNP cord-265279-0zjpqnqp 42 6 , , , cord-265279-0zjpqnqp 42 7 2014 2014 CD cord-265279-0zjpqnqp 42 8 ) ) -RRB- cord-265279-0zjpqnqp 42 9 . . . cord-265279-0zjpqnqp 43 1 Other other JJ cord-265279-0zjpqnqp 43 2 reported report VBN cord-265279-0zjpqnqp 43 3 cases case NNS cord-265279-0zjpqnqp 43 4 of of IN cord-265279-0zjpqnqp 43 5 MERS MERS NNP cord-265279-0zjpqnqp 43 6 - - HYPH cord-265279-0zjpqnqp 43 7 CoV CoV NNP cord-265279-0zjpqnqp 43 8 , , , cord-265279-0zjpqnqp 43 9 especially especially RB cord-265279-0zjpqnqp 43 10 the the DT cord-265279-0zjpqnqp 43 11 ones one NNS cord-265279-0zjpqnqp 43 12 reported report VBN cord-265279-0zjpqnqp 43 13 in in IN cord-265279-0zjpqnqp 43 14 Europe Europe NNP cord-265279-0zjpqnqp 43 15 or or CC cord-265279-0zjpqnqp 43 16 the the DT cord-265279-0zjpqnqp 43 17 US US NNP cord-265279-0zjpqnqp 43 18 are be VBP cord-265279-0zjpqnqp 43 19 more more RBR cord-265279-0zjpqnqp 43 20 likely likely RB cord-265279-0zjpqnqp 43 21 associated associate VBN cord-265279-0zjpqnqp 43 22 with with IN cord-265279-0zjpqnqp 43 23 the the DT cord-265279-0zjpqnqp 43 24 travel travel NN cord-265279-0zjpqnqp 43 25 history history NN cord-265279-0zjpqnqp 43 26 to to IN cord-265279-0zjpqnqp 43 27 the the DT cord-265279-0zjpqnqp 43 28 Middle Middle NNP cord-265279-0zjpqnqp 43 29 East East NNP cord-265279-0zjpqnqp 43 30 . . . cord-265279-0zjpqnqp 44 1 The the DT cord-265279-0zjpqnqp 44 2 rate rate NN cord-265279-0zjpqnqp 44 3 transmission transmission NN cord-265279-0zjpqnqp 44 4 of of IN cord-265279-0zjpqnqp 44 5 the the DT cord-265279-0zjpqnqp 44 6 virus virus NN cord-265279-0zjpqnqp 44 7 from from IN cord-265279-0zjpqnqp 44 8 infected infected JJ cord-265279-0zjpqnqp 44 9 patients patient NNS cord-265279-0zjpqnqp 44 10 to to IN cord-265279-0zjpqnqp 44 11 their -PRON- PRP$ cord-265279-0zjpqnqp 44 12 household household NN cord-265279-0zjpqnqp 44 13 contacts contact NNS cord-265279-0zjpqnqp 44 14 is be VBZ cord-265279-0zjpqnqp 44 15 as as RB cord-265279-0zjpqnqp 44 16 low low JJ cord-265279-0zjpqnqp 44 17 as as IN cord-265279-0zjpqnqp 44 18 5 5 CD cord-265279-0zjpqnqp 44 19 % % NN cord-265279-0zjpqnqp 44 20 ( ( -LRB- cord-265279-0zjpqnqp 44 21 Drosten Drosten NNP cord-265279-0zjpqnqp 44 22 et et FW cord-265279-0zjpqnqp 44 23 al al NNP cord-265279-0zjpqnqp 44 24 . . NNP cord-265279-0zjpqnqp 44 25 , , , cord-265279-0zjpqnqp 44 26 2014 2014 CD cord-265279-0zjpqnqp 44 27 ) ) -RRB- cord-265279-0zjpqnqp 44 28 . . . cord-265279-0zjpqnqp 45 1 Rapid rapid JJ cord-265279-0zjpqnqp 45 2 detection detection NN cord-265279-0zjpqnqp 45 3 and and CC cord-265279-0zjpqnqp 45 4 implementation implementation NN cord-265279-0zjpqnqp 45 5 of of IN cord-265279-0zjpqnqp 45 6 proper proper JJ cord-265279-0zjpqnqp 45 7 infection infection NN cord-265279-0zjpqnqp 45 8 control control NN cord-265279-0zjpqnqp 45 9 measures measure NNS cord-265279-0zjpqnqp 45 10 are be VBP cord-265279-0zjpqnqp 45 11 two two CD cord-265279-0zjpqnqp 45 12 essential essential JJ cord-265279-0zjpqnqp 45 13 steps step NNS cord-265279-0zjpqnqp 45 14 to to TO cord-265279-0zjpqnqp 45 15 limit limit VB cord-265279-0zjpqnqp 45 16 and and CC cord-265279-0zjpqnqp 45 17 control control VB cord-265279-0zjpqnqp 45 18 MERS MERS NNP cord-265279-0zjpqnqp 45 19 - - HYPH cord-265279-0zjpqnqp 45 20 CoV CoV NNP cord-265279-0zjpqnqp 45 21 transmission transmission NN cord-265279-0zjpqnqp 45 22 in in IN cord-265279-0zjpqnqp 45 23 healthcare healthcare NN cord-265279-0zjpqnqp 45 24 settings setting NNS cord-265279-0zjpqnqp 45 25 . . . cord-265279-0zjpqnqp 46 1 This this DT cord-265279-0zjpqnqp 46 2 includes include VBZ cord-265279-0zjpqnqp 46 3 applying apply VBG cord-265279-0zjpqnqp 46 4 contact contact NN cord-265279-0zjpqnqp 46 5 and and CC cord-265279-0zjpqnqp 46 6 airborne airborne JJ cord-265279-0zjpqnqp 46 7 precautions precaution NNS cord-265279-0zjpqnqp 46 8 such such JJ cord-265279-0zjpqnqp 46 9 as as IN cord-265279-0zjpqnqp 46 10 wearing wear VBG cord-265279-0zjpqnqp 46 11 gloves glove NNS cord-265279-0zjpqnqp 46 12 , , , cord-265279-0zjpqnqp 46 13 gowns gown NNS cord-265279-0zjpqnqp 46 14 and and CC cord-265279-0zjpqnqp 46 15 surgical surgical JJ cord-265279-0zjpqnqp 46 16 masks mask NNS cord-265279-0zjpqnqp 46 17 upon upon IN cord-265279-0zjpqnqp 46 18 entry entry NN cord-265279-0zjpqnqp 46 19 to to IN cord-265279-0zjpqnqp 46 20 a a DT cord-265279-0zjpqnqp 46 21 room room NN cord-265279-0zjpqnqp 46 22 of of IN cord-265279-0zjpqnqp 46 23 MERS MERS NNP cord-265279-0zjpqnqp 46 24 - - HYPH cord-265279-0zjpqnqp 46 25 CoV CoV NNP cord-265279-0zjpqnqp 46 26 infected infect VBN cord-265279-0zjpqnqp 46 27 patient patient NN cord-265279-0zjpqnqp 46 28 in in IN cord-265279-0zjpqnqp 46 29 isolation isolation NN cord-265279-0zjpqnqp 46 30 and and CC cord-265279-0zjpqnqp 46 31 removing remove VBG cord-265279-0zjpqnqp 46 32 such such JJ cord-265279-0zjpqnqp 46 33 personal personal JJ cord-265279-0zjpqnqp 46 34 protective protective JJ cord-265279-0zjpqnqp 46 35 equipment equipment NN cord-265279-0zjpqnqp 46 36 upon upon IN cord-265279-0zjpqnqp 46 37 leaving leave VBG cord-265279-0zjpqnqp 46 38 the the DT cord-265279-0zjpqnqp 46 39 room room NN cord-265279-0zjpqnqp 46 40 ( ( -LRB- cord-265279-0zjpqnqp 46 41 Zumla Zumla NNP cord-265279-0zjpqnqp 46 42 and and CC cord-265279-0zjpqnqp 46 43 Hui Hui NNP cord-265279-0zjpqnqp 46 44 , , , cord-265279-0zjpqnqp 46 45 2014 2014 CD cord-265279-0zjpqnqp 46 46 ) ) -RRB- cord-265279-0zjpqnqp 46 47 . . . cord-265279-0zjpqnqp 47 1 Protective protective JJ cord-265279-0zjpqnqp 47 2 measures measure NNS cord-265279-0zjpqnqp 47 3 outside outside IN cord-265279-0zjpqnqp 47 4 healthcare healthcare NN cord-265279-0zjpqnqp 47 5 settings setting NNS cord-265279-0zjpqnqp 47 6 include include VBP cord-265279-0zjpqnqp 47 7 avoiding avoid VBG cord-265279-0zjpqnqp 47 8 contact contact NN cord-265279-0zjpqnqp 47 9 with with IN cord-265279-0zjpqnqp 47 10 dromedary dromedary NN cord-265279-0zjpqnqp 47 11 camels camel NNS cord-265279-0zjpqnqp 47 12 , , , cord-265279-0zjpqnqp 47 13 the the DT cord-265279-0zjpqnqp 47 14 host host NN cord-265279-0zjpqnqp 47 15 of of IN cord-265279-0zjpqnqp 47 16 MERS MERS NNP cord-265279-0zjpqnqp 47 17 - - HYPH cord-265279-0zjpqnqp 47 18 CoV CoV NNP cord-265279-0zjpqnqp 47 19 , , , cord-265279-0zjpqnqp 47 20 and and CC cord-265279-0zjpqnqp 47 21 restraining restrain VBG cord-265279-0zjpqnqp 47 22 from from IN cord-265279-0zjpqnqp 47 23 drinking drink VBG cord-265279-0zjpqnqp 47 24 camel camel NN cord-265279-0zjpqnqp 47 25 urine urine NN cord-265279-0zjpqnqp 47 26 or or CC cord-265279-0zjpqnqp 47 27 raw raw JJ cord-265279-0zjpqnqp 47 28 milk milk NN cord-265279-0zjpqnqp 47 29 or or CC cord-265279-0zjpqnqp 47 30 eating eat VBG cord-265279-0zjpqnqp 47 31 raw raw JJ cord-265279-0zjpqnqp 47 32 or or CC cord-265279-0zjpqnqp 47 33 undercooked undercooked JJ cord-265279-0zjpqnqp 47 34 camel camel NN cord-265279-0zjpqnqp 47 35 meat meat NN cord-265279-0zjpqnqp 47 36 . . . cord-265279-0zjpqnqp 48 1 Moreover moreover RB cord-265279-0zjpqnqp 48 2 people people NNS cord-265279-0zjpqnqp 48 3 working work VBG cord-265279-0zjpqnqp 48 4 with with IN cord-265279-0zjpqnqp 48 5 camels camel NNS cord-265279-0zjpqnqp 48 6 must must MD cord-265279-0zjpqnqp 48 7 wear wear VB cord-265279-0zjpqnqp 48 8 protective protective JJ cord-265279-0zjpqnqp 48 9 clothing clothing NN cord-265279-0zjpqnqp 48 10 and and CC cord-265279-0zjpqnqp 48 11 facial facial JJ cord-265279-0zjpqnqp 48 12 masks mask NNS cord-265279-0zjpqnqp 48 13 , , , cord-265279-0zjpqnqp 48 14 and and CC cord-265279-0zjpqnqp 48 15 maintain maintain VB cord-265279-0zjpqnqp 48 16 a a DT cord-265279-0zjpqnqp 48 17 good good JJ cord-265279-0zjpqnqp 48 18 personal personal JJ cord-265279-0zjpqnqp 48 19 hygiene hygiene NN cord-265279-0zjpqnqp 48 20 ( ( -LRB- cord-265279-0zjpqnqp 48 21 Reusken reusken FW cord-265279-0zjpqnqp 48 22 et et FW cord-265279-0zjpqnqp 48 23 al al NNP cord-265279-0zjpqnqp 48 24 . . NNP cord-265279-0zjpqnqp 48 25 , , , cord-265279-0zjpqnqp 48 26 2014 2014 CD cord-265279-0zjpqnqp 48 27 ) ) -RRB- cord-265279-0zjpqnqp 48 28 . . . cord-265279-0zjpqnqp 49 1 Ideally ideally RB cord-265279-0zjpqnqp 49 2 , , , cord-265279-0zjpqnqp 49 3 lower low JJR cord-265279-0zjpqnqp 49 4 respiratory respiratory JJ cord-265279-0zjpqnqp 49 5 specimens specimen NNS cord-265279-0zjpqnqp 49 6 such such JJ cord-265279-0zjpqnqp 49 7 as as IN cord-265279-0zjpqnqp 49 8 sputum sputum NN cord-265279-0zjpqnqp 49 9 , , , cord-265279-0zjpqnqp 49 10 bronchoalveolar bronchoalveolar NNP cord-265279-0zjpqnqp 49 11 lavage lavage NN cord-265279-0zjpqnqp 49 12 , , , cord-265279-0zjpqnqp 49 13 bronchial bronchial JJ cord-265279-0zjpqnqp 49 14 wash wash NN cord-265279-0zjpqnqp 49 15 and and CC cord-265279-0zjpqnqp 49 16 tracheal tracheal JJ cord-265279-0zjpqnqp 49 17 aspirates aspirate NNS cord-265279-0zjpqnqp 49 18 are be VBP cord-265279-0zjpqnqp 49 19 the the DT cord-265279-0zjpqnqp 49 20 most most RBS cord-265279-0zjpqnqp 49 21 representative representative JJ cord-265279-0zjpqnqp 49 22 and and CC cord-265279-0zjpqnqp 49 23 appropriate appropriate JJ cord-265279-0zjpqnqp 49 24 for for IN cord-265279-0zjpqnqp 49 25 MERS MERS NNP cord-265279-0zjpqnqp 49 26 - - HYPH cord-265279-0zjpqnqp 49 27 CoV CoV NNP cord-265279-0zjpqnqp 49 28 testing testing NN cord-265279-0zjpqnqp 49 29 ( ( -LRB- cord-265279-0zjpqnqp 49 30 CDC CDC NNP cord-265279-0zjpqnqp 49 31 , , , cord-265279-0zjpqnqp 49 32 June June NNP cord-265279-0zjpqnqp 49 33 14 14 CD cord-265279-0zjpqnqp 49 34 , , , cord-265279-0zjpqnqp 49 35 2013 2013 CD cord-265279-0zjpqnqp 49 36 ) ) -RRB- cord-265279-0zjpqnqp 49 37 . . . cord-265279-0zjpqnqp 50 1 The the DT cord-265279-0zjpqnqp 50 2 name name NN cord-265279-0zjpqnqp 50 3 of of IN cord-265279-0zjpqnqp 50 4 the the DT cord-265279-0zjpqnqp 50 5 virus virus NN cord-265279-0zjpqnqp 50 6 is be VBZ cord-265279-0zjpqnqp 50 7 derived derive VBN cord-265279-0zjpqnqp 50 8 from from IN cord-265279-0zjpqnqp 50 9 the the DT cord-265279-0zjpqnqp 50 10 area area NN cord-265279-0zjpqnqp 50 11 of of IN cord-265279-0zjpqnqp 50 12 its -PRON- PRP$ cord-265279-0zjpqnqp 50 13 appearance appearance NN cord-265279-0zjpqnqp 50 14 and and CC cord-265279-0zjpqnqp 50 15 the the DT cord-265279-0zjpqnqp 50 16 genomic genomic JJ cord-265279-0zjpqnqp 50 17 sequence sequence NN cord-265279-0zjpqnqp 50 18 that that WDT cord-265279-0zjpqnqp 50 19 was be VBD cord-265279-0zjpqnqp 50 20 used use VBN cord-265279-0zjpqnqp 50 21 in in IN cord-265279-0zjpqnqp 50 22 the the DT cord-265279-0zjpqnqp 50 23 development development NN cord-265279-0zjpqnqp 50 24 of of IN cord-265279-0zjpqnqp 50 25 qRT qRT NNP cord-265279-0zjpqnqp 50 26 - - HYPH cord-265279-0zjpqnqp 50 27 PCR PCR NNP cord-265279-0zjpqnqp 50 28 assays assay NNS cord-265279-0zjpqnqp 50 29 for for IN cord-265279-0zjpqnqp 50 30 MERS MERS NNP cord-265279-0zjpqnqp 50 31 - - HYPH cord-265279-0zjpqnqp 50 32 CoV CoV NNP cord-265279-0zjpqnqp 50 33 detection detection NN cord-265279-0zjpqnqp 50 34 was be VBD cord-265279-0zjpqnqp 50 35 retrieved retrieve VBN cord-265279-0zjpqnqp 50 36 from from IN cord-265279-0zjpqnqp 50 37 the the DT cord-265279-0zjpqnqp 50 38 first first JJ cord-265279-0zjpqnqp 50 39 detected detect VBN cord-265279-0zjpqnqp 50 40 case case NN cord-265279-0zjpqnqp 50 41 isolate isolate VB cord-265279-0zjpqnqp 50 42 ( ( -LRB- cord-265279-0zjpqnqp 50 43 Lu Lu NNP cord-265279-0zjpqnqp 50 44 et et FW cord-265279-0zjpqnqp 50 45 al al NNP cord-265279-0zjpqnqp 50 46 . . NNP cord-265279-0zjpqnqp 50 47 , , , cord-265279-0zjpqnqp 50 48 2014 2014 CD cord-265279-0zjpqnqp 50 49 ) ) -RRB- cord-265279-0zjpqnqp 50 50 . . . cord-265279-0zjpqnqp 51 1 The the DT cord-265279-0zjpqnqp 51 2 employed employ VBN cord-265279-0zjpqnqp 51 3 assays assay NNS cord-265279-0zjpqnqp 51 4 target target VBP cord-265279-0zjpqnqp 51 5 various various JJ cord-265279-0zjpqnqp 51 6 regions region NNS cord-265279-0zjpqnqp 51 7 including include VBG cord-265279-0zjpqnqp 51 8 the the DT cord-265279-0zjpqnqp 51 9 area area NN cord-265279-0zjpqnqp 51 10 upstream upstream RB cord-265279-0zjpqnqp 51 11 of of IN cord-265279-0zjpqnqp 51 12 the the DT cord-265279-0zjpqnqp 51 13 envelope envelope NN cord-265279-0zjpqnqp 51 14 gene gene NN cord-265279-0zjpqnqp 51 15 ( ( -LRB- cord-265279-0zjpqnqp 51 16 upE upE NNP cord-265279-0zjpqnqp 51 17 ) ) -RRB- cord-265279-0zjpqnqp 51 18 that that WDT cord-265279-0zjpqnqp 51 19 is be VBZ cord-265279-0zjpqnqp 51 20 used use VBN cord-265279-0zjpqnqp 51 21 for for IN cord-265279-0zjpqnqp 51 22 screening screening NN cord-265279-0zjpqnqp 51 23 and and CC cord-265279-0zjpqnqp 51 24 the the DT cord-265279-0zjpqnqp 51 25 open open JJ cord-265279-0zjpqnqp 51 26 reading reading NN cord-265279-0zjpqnqp 51 27 frames frame NNS cord-265279-0zjpqnqp 51 28 ( ( -LRB- cord-265279-0zjpqnqp 51 29 ORF ORF NNP cord-265279-0zjpqnqp 51 30 ) ) -RRB- cord-265279-0zjpqnqp 51 31 1a 1a NN cord-265279-0zjpqnqp 51 32 and and CC cord-265279-0zjpqnqp 51 33 1b 1b CD cord-265279-0zjpqnqp 51 34 used use VBN cord-265279-0zjpqnqp 51 35 for for IN cord-265279-0zjpqnqp 51 36 confirmation confirmation NN cord-265279-0zjpqnqp 51 37 . . . cord-265279-0zjpqnqp 52 1 The the DT cord-265279-0zjpqnqp 52 2 aim aim NN cord-265279-0zjpqnqp 52 3 of of IN cord-265279-0zjpqnqp 52 4 this this DT cord-265279-0zjpqnqp 52 5 study study NN cord-265279-0zjpqnqp 52 6 was be VBD cord-265279-0zjpqnqp 52 7 to to TO cord-265279-0zjpqnqp 52 8 assess assess VB cord-265279-0zjpqnqp 52 9 the the DT cord-265279-0zjpqnqp 52 10 use use NN cord-265279-0zjpqnqp 52 11 of of IN cord-265279-0zjpqnqp 52 12 a a DT cord-265279-0zjpqnqp 52 13 MERS MERS NNP cord-265279-0zjpqnqp 52 14 - - HYPH cord-265279-0zjpqnqp 52 15 CoV cov NN cord-265279-0zjpqnqp 52 16 specific specific JJ cord-265279-0zjpqnqp 52 17 assay assay NN cord-265279-0zjpqnqp 52 18 for for IN cord-265279-0zjpqnqp 52 19 screening screening NN cord-265279-0zjpqnqp 52 20 of of IN cord-265279-0zjpqnqp 52 21 respiratory respiratory JJ cord-265279-0zjpqnqp 52 22 samples sample NNS cord-265279-0zjpqnqp 52 23 referred refer VBN cord-265279-0zjpqnqp 52 24 to to IN cord-265279-0zjpqnqp 52 25 a a DT cord-265279-0zjpqnqp 52 26 major major JJ cord-265279-0zjpqnqp 52 27 tertiary tertiary JJ cord-265279-0zjpqnqp 52 28 care care NN cord-265279-0zjpqnqp 52 29 center center NN cord-265279-0zjpqnqp 52 30 in in IN cord-265279-0zjpqnqp 52 31 anticipation anticipation NN cord-265279-0zjpqnqp 52 32 of of IN cord-265279-0zjpqnqp 52 33 the the DT cord-265279-0zjpqnqp 52 34 possible possible JJ cord-265279-0zjpqnqp 52 35 spread spread NN cord-265279-0zjpqnqp 52 36 of of IN cord-265279-0zjpqnqp 52 37 the the DT cord-265279-0zjpqnqp 52 38 virus virus NN cord-265279-0zjpqnqp 52 39 in in IN cord-265279-0zjpqnqp 52 40 the the DT cord-265279-0zjpqnqp 52 41 region region NN cord-265279-0zjpqnqp 52 42 . . . cord-265279-0zjpqnqp 53 1 RNA RNA NNP cord-265279-0zjpqnqp 53 2 was be VBD cord-265279-0zjpqnqp 53 3 extracted extract VBN cord-265279-0zjpqnqp 53 4 from from IN cord-265279-0zjpqnqp 53 5 46 46 CD cord-265279-0zjpqnqp 53 6 respiratory respiratory JJ cord-265279-0zjpqnqp 53 7 specimens specimen NNS cord-265279-0zjpqnqp 53 8 using use VBG cord-265279-0zjpqnqp 53 9 the the DT cord-265279-0zjpqnqp 53 10 QIAamp QIAamp NNP cord-265279-0zjpqnqp 53 11 viral viral JJ cord-265279-0zjpqnqp 53 12 RNA RNA NNP cord-265279-0zjpqnqp 53 13 mini mini JJ cord-265279-0zjpqnqp 53 14 kit kit NN cord-265279-0zjpqnqp 53 15 ( ( -LRB- cord-265279-0zjpqnqp 53 16 QIAGEN QIAGEN NNP cord-265279-0zjpqnqp 53 17 , , , cord-265279-0zjpqnqp 53 18 Hilden Hilden NNP cord-265279-0zjpqnqp 53 19 , , , cord-265279-0zjpqnqp 53 20 Germany Germany NNP cord-265279-0zjpqnqp 53 21 ) ) -RRB- cord-265279-0zjpqnqp 53 22 that that WDT cord-265279-0zjpqnqp 53 23 does do VBZ cord-265279-0zjpqnqp 53 24 not not RB cord-265279-0zjpqnqp 53 25 use use VB cord-265279-0zjpqnqp 53 26 phenol/ phenol/ JJ cord-265279-0zjpqnqp 53 27 chloroform chloroform NN cord-265279-0zjpqnqp 53 28 extraction extraction NN cord-265279-0zjpqnqp 53 29 or or CC cord-265279-0zjpqnqp 53 30 alcohol alcohol NN cord-265279-0zjpqnqp 53 31 precipitation precipitation NN cord-265279-0zjpqnqp 53 32 protocols protocol NNS cord-265279-0zjpqnqp 53 33 . . . cord-265279-0zjpqnqp 54 1 Briefly briefly RB cord-265279-0zjpqnqp 54 2 , , , cord-265279-0zjpqnqp 54 3 a a DT cord-265279-0zjpqnqp 54 4 lysis lysis NN cord-265279-0zjpqnqp 54 5 buffer buffer NN cord-265279-0zjpqnqp 54 6 was be VBD cord-265279-0zjpqnqp 54 7 used use VBN cord-265279-0zjpqnqp 54 8 to to TO cord-265279-0zjpqnqp 54 9 isolate isolate VB cord-265279-0zjpqnqp 54 10 non non JJ cord-265279-0zjpqnqp 54 11 - - JJ cord-265279-0zjpqnqp 54 12 degraded degraded JJ cord-265279-0zjpqnqp 54 13 viral viral JJ cord-265279-0zjpqnqp 54 14 RNA rna NN cord-265279-0zjpqnqp 54 15 and and CC cord-265279-0zjpqnqp 54 16 inactivate inactivate VB cord-265279-0zjpqnqp 54 17 RNAses RNAses NNP cord-265279-0zjpqnqp 54 18 . . . cord-265279-0zjpqnqp 55 1 The the DT cord-265279-0zjpqnqp 55 2 sample sample NN cord-265279-0zjpqnqp 55 3 was be VBD cord-265279-0zjpqnqp 55 4 then then RB cord-265279-0zjpqnqp 55 5 transferred transfer VBN cord-265279-0zjpqnqp 55 6 to to IN cord-265279-0zjpqnqp 55 7 the the DT cord-265279-0zjpqnqp 55 8 QIAamp QIAamp NNP cord-265279-0zjpqnqp 55 9 Mini Mini NNP cord-265279-0zjpqnqp 55 10 spin spin NN cord-265279-0zjpqnqp 55 11 column column NN cord-265279-0zjpqnqp 55 12 under under IN cord-265279-0zjpqnqp 55 13 optimal optimal JJ cord-265279-0zjpqnqp 55 14 conditions condition NNS cord-265279-0zjpqnqp 55 15 that that WDT cord-265279-0zjpqnqp 55 16 ensured ensure VBD cord-265279-0zjpqnqp 55 17 effective effective JJ cord-265279-0zjpqnqp 55 18 binding binding NN cord-265279-0zjpqnqp 55 19 of of IN cord-265279-0zjpqnqp 55 20 the the DT cord-265279-0zjpqnqp 55 21 RNA RNA NNP cord-265279-0zjpqnqp 55 22 to to IN cord-265279-0zjpqnqp 55 23 the the DT cord-265279-0zjpqnqp 55 24 QIAamp QIAamp NNP cord-265279-0zjpqnqp 55 25 membrane membrane NN cord-265279-0zjpqnqp 55 26 . . . cord-265279-0zjpqnqp 56 1 Possible possible JJ cord-265279-0zjpqnqp 56 2 contaminants contaminant NNS cord-265279-0zjpqnqp 56 3 were be VBD cord-265279-0zjpqnqp 56 4 removed remove VBN cord-265279-0zjpqnqp 56 5 using use VBG cord-265279-0zjpqnqp 56 6 two two CD cord-265279-0zjpqnqp 56 7 different different JJ cord-265279-0zjpqnqp 56 8 wash wash NN cord-265279-0zjpqnqp 56 9 buffers buffer NNS cord-265279-0zjpqnqp 56 10 , , , cord-265279-0zjpqnqp 56 11 then then RB cord-265279-0zjpqnqp 56 12 , , , cord-265279-0zjpqnqp 56 13 a a DT cord-265279-0zjpqnqp 56 14 RNase rnase NN cord-265279-0zjpqnqp 56 15 - - HYPH cord-265279-0zjpqnqp 56 16 free free JJ cord-265279-0zjpqnqp 56 17 buffer buffer NN cord-265279-0zjpqnqp 56 18 was be VBD cord-265279-0zjpqnqp 56 19 employed employ VBN cord-265279-0zjpqnqp 56 20 to to TO cord-265279-0zjpqnqp 56 21 elute elute VB cord-265279-0zjpqnqp 56 22 the the DT cord-265279-0zjpqnqp 56 23 RNA RNA NNP cord-265279-0zjpqnqp 56 24 . . . cord-265279-0zjpqnqp 57 1 MERS MERS NNP cord-265279-0zjpqnqp 57 2 - - HYPH cord-265279-0zjpqnqp 57 3 Coronavirus Coronavirus NNP cord-265279-0zjpqnqp 58 1 qualitative qualitative JJ cord-265279-0zjpqnqp 58 2 one one CD cord-265279-0zjpqnqp 58 3 - - HYPH cord-265279-0zjpqnqp 58 4 step step NN cord-265279-0zjpqnqp 58 5 qRT qrt ADD cord-265279-0zjpqnqp 58 6 - - HYPH cord-265279-0zjpqnqp 58 7 PCR PCR NNP cord-265279-0zjpqnqp 58 8 testing testing NN cord-265279-0zjpqnqp 58 9 was be VBD cord-265279-0zjpqnqp 58 10 done do VBN cord-265279-0zjpqnqp 58 11 using use VBG cord-265279-0zjpqnqp 58 12 the the DT cord-265279-0zjpqnqp 58 13 GeneSig GeneSig NNP cord-265279-0zjpqnqp 58 14 Human Human NNP cord-265279-0zjpqnqp 58 15 Coronavirus Coronavirus NNP cord-265279-0zjpqnqp 58 16 2012 2012 CD cord-265279-0zjpqnqp 58 17 ( ( -LRB- cord-265279-0zjpqnqp 58 18 MERS MERS NNP cord-265279-0zjpqnqp 58 19 ) ) -RRB- cord-265279-0zjpqnqp 58 20 kit kit NN cord-265279-0zjpqnqp 58 21 ( ( -LRB- cord-265279-0zjpqnqp 58 22 PrimerDesign PrimerDesign NNP cord-265279-0zjpqnqp 58 23 ™ ™ NN cord-265279-0zjpqnqp 58 24 , , , cord-265279-0zjpqnqp 58 25 London London NNP cord-265279-0zjpqnqp 58 26 , , , cord-265279-0zjpqnqp 58 27 UK UK NNP cord-265279-0zjpqnqp 58 28 ) ) -RRB- cord-265279-0zjpqnqp 58 29 . . . cord-265279-0zjpqnqp 59 1 The the DT cord-265279-0zjpqnqp 59 2 HCoV HCoV NNP cord-265279-0zjpqnqp 59 3 primers primer NNS cord-265279-0zjpqnqp 59 4 are be VBP cord-265279-0zjpqnqp 59 5 designed design VBN cord-265279-0zjpqnqp 59 6 for for IN cord-265279-0zjpqnqp 59 7 the the DT cord-265279-0zjpqnqp 59 8 specific specific JJ cord-265279-0zjpqnqp 59 9 and and CC cord-265279-0zjpqnqp 59 10 exclusive exclusive JJ cord-265279-0zjpqnqp 59 11 in in FW cord-265279-0zjpqnqp 59 12 vitro vitro FW cord-265279-0zjpqnqp 59 13 detection detection NN cord-265279-0zjpqnqp 59 14 of of IN cord-265279-0zjpqnqp 59 15 the the DT cord-265279-0zjpqnqp 59 16 novel novel JJ cord-265279-0zjpqnqp 59 17 coronavirus coronavirus NN cord-265279-0zjpqnqp 59 18 isolates isolate VBZ cord-265279-0zjpqnqp 59 19 based base VBN cord-265279-0zjpqnqp 59 20 on on IN cord-265279-0zjpqnqp 59 21 sequences sequence NNS cord-265279-0zjpqnqp 59 22 for for IN cord-265279-0zjpqnqp 59 23 the the DT cord-265279-0zjpqnqp 59 24 EMC EMC NNP cord-265279-0zjpqnqp 59 25 strain strain NN cord-265279-0zjpqnqp 59 26 by by IN cord-265279-0zjpqnqp 59 27 targeting target VBG cord-265279-0zjpqnqp 59 28 the the DT cord-265279-0zjpqnqp 59 29 ORF1ab ORF1ab NNP cord-265279-0zjpqnqp 59 30 and and CC cord-265279-0zjpqnqp 59 31 the the DT cord-265279-0zjpqnqp 59 32 upE upe JJ cord-265279-0zjpqnqp 59 33 regions region NNS cord-265279-0zjpqnqp 59 34 of of IN cord-265279-0zjpqnqp 59 35 ORF5 ORF5 NNP cord-265279-0zjpqnqp 59 36 . . . cord-265279-0zjpqnqp 60 1 The the DT cord-265279-0zjpqnqp 60 2 ORF1ab ORF1ab NNP cord-265279-0zjpqnqp 61 1 and and CC cord-265279-0zjpqnqp 61 2 ORF5 ORF5 NNP cord-265279-0zjpqnqp 61 3 / / SYM cord-265279-0zjpqnqp 61 4 E e NN cord-265279-0zjpqnqp 61 5 primer primer NN cord-265279-0zjpqnqp 61 6 and and CC cord-265279-0zjpqnqp 61 7 probe probe NN cord-265279-0zjpqnqp 61 8 sets set NNS cord-265279-0zjpqnqp 61 9 are be VBP cord-265279-0zjpqnqp 61 10 designed design VBN cord-265279-0zjpqnqp 61 11 to to TO cord-265279-0zjpqnqp 61 12 be be VB cord-265279-0zjpqnqp 61 13 specific specific JJ cord-265279-0zjpqnqp 61 14 to to IN cord-265279-0zjpqnqp 61 15 the the DT cord-265279-0zjpqnqp 61 16 MERS MERS NNP cord-265279-0zjpqnqp 61 17 strain strain VBP cord-265279-0zjpqnqp 61 18 regardless regardless RB cord-265279-0zjpqnqp 61 19 of of IN cord-265279-0zjpqnqp 61 20 the the DT cord-265279-0zjpqnqp 61 21 species specie NNS cord-265279-0zjpqnqp 61 22 of of IN cord-265279-0zjpqnqp 61 23 origin origin NN cord-265279-0zjpqnqp 61 24 and and CC cord-265279-0zjpqnqp 61 25 are be VBP cord-265279-0zjpqnqp 61 26 detected detect VBN cord-265279-0zjpqnqp 61 27 through through IN cord-265279-0zjpqnqp 61 28 the the DT cord-265279-0zjpqnqp 61 29 FAM FAM NNP cord-265279-0zjpqnqp 61 30 channel channel NN cord-265279-0zjpqnqp 61 31 . . . cord-265279-0zjpqnqp 62 1 An an DT cord-265279-0zjpqnqp 62 2 internal internal JJ cord-265279-0zjpqnqp 62 3 RNA RNA NNP cord-265279-0zjpqnqp 62 4 extraction extraction NN cord-265279-0zjpqnqp 62 5 control control NN cord-265279-0zjpqnqp 62 6 is be VBZ cord-265279-0zjpqnqp 62 7 available available JJ cord-265279-0zjpqnqp 62 8 in in IN cord-265279-0zjpqnqp 62 9 the the DT cord-265279-0zjpqnqp 62 10 kit kit NN cord-265279-0zjpqnqp 62 11 and and CC cord-265279-0zjpqnqp 62 12 was be VBD cord-265279-0zjpqnqp 62 13 added add VBN cord-265279-0zjpqnqp 62 14 to to IN cord-265279-0zjpqnqp 62 15 the the DT cord-265279-0zjpqnqp 62 16 lysis lysis NN cord-265279-0zjpqnqp 62 17 buffer buffer NN cord-265279-0zjpqnqp 62 18 as as IN cord-265279-0zjpqnqp 62 19 an an DT cord-265279-0zjpqnqp 62 20 external external JJ cord-265279-0zjpqnqp 62 21 source source NN cord-265279-0zjpqnqp 62 22 of of IN cord-265279-0zjpqnqp 62 23 RNA rna NN cord-265279-0zjpqnqp 62 24 template template NN cord-265279-0zjpqnqp 62 25 , , , cord-265279-0zjpqnqp 62 26 during during IN cord-265279-0zjpqnqp 62 27 the the DT cord-265279-0zjpqnqp 62 28 extraction extraction NN cord-265279-0zjpqnqp 62 29 step step NN cord-265279-0zjpqnqp 62 30 , , , cord-265279-0zjpqnqp 62 31 and and CC cord-265279-0zjpqnqp 62 32 co co JJ cord-265279-0zjpqnqp 62 33 - - VBN cord-265279-0zjpqnqp 62 34 purified purify VBN cord-265279-0zjpqnqp 62 35 with with IN cord-265279-0zjpqnqp 62 36 the the DT cord-265279-0zjpqnqp 62 37 sample sample NN cord-265279-0zjpqnqp 62 38 RNA RNA NNP cord-265279-0zjpqnqp 62 39 to to TO cord-265279-0zjpqnqp 62 40 monitor monitor VB cord-265279-0zjpqnqp 62 41 this this DT cord-265279-0zjpqnqp 62 42 process process NN cord-265279-0zjpqnqp 62 43 as as RB cord-265279-0zjpqnqp 62 44 well well RB cord-265279-0zjpqnqp 62 45 as as IN cord-265279-0zjpqnqp 62 46 to to TO cord-265279-0zjpqnqp 62 47 rule rule VB cord-265279-0zjpqnqp 62 48 out out RP cord-265279-0zjpqnqp 62 49 the the DT cord-265279-0zjpqnqp 62 50 presence presence NN cord-265279-0zjpqnqp 62 51 of of IN cord-265279-0zjpqnqp 62 52 inhibitors inhibitor NNS cord-265279-0zjpqnqp 62 53 in in IN cord-265279-0zjpqnqp 62 54 the the DT cord-265279-0zjpqnqp 62 55 realtime realtime NNP cord-265279-0zjpqnqp 62 56 PCR PCR NNP cord-265279-0zjpqnqp 62 57 step step NN cord-265279-0zjpqnqp 62 58 . . . cord-265279-0zjpqnqp 63 1 For for IN cord-265279-0zjpqnqp 63 2 the the DT cord-265279-0zjpqnqp 63 3 latter latter JJ cord-265279-0zjpqnqp 63 4 purpose purpose NN cord-265279-0zjpqnqp 63 5 , , , cord-265279-0zjpqnqp 63 6 a a DT cord-265279-0zjpqnqp 63 7 separate separate JJ cord-265279-0zjpqnqp 63 8 mix mix NN cord-265279-0zjpqnqp 63 9 of of IN cord-265279-0zjpqnqp 63 10 primers primer NNS cord-265279-0zjpqnqp 63 11 for for IN cord-265279-0zjpqnqp 63 12 the the DT cord-265279-0zjpqnqp 63 13 internal internal JJ cord-265279-0zjpqnqp 63 14 control control NN cord-265279-0zjpqnqp 63 15 , , , cord-265279-0zjpqnqp 63 16 with with IN cord-265279-0zjpqnqp 63 17 limited limited JJ cord-265279-0zjpqnqp 63 18 concentrations concentration NNS cord-265279-0zjpqnqp 63 19 that that WDT cord-265279-0zjpqnqp 63 20 allow allow VBP cord-265279-0zjpqnqp 63 21 for for IN cord-265279-0zjpqnqp 63 22 multiplexing multiplexe VBG cord-265279-0zjpqnqp 63 23 with with IN cord-265279-0zjpqnqp 63 24 the the DT cord-265279-0zjpqnqp 63 25 target target NN cord-265279-0zjpqnqp 63 26 sequence sequence NN cord-265279-0zjpqnqp 63 27 primers primer NNS cord-265279-0zjpqnqp 63 28 without without IN cord-265279-0zjpqnqp 63 29 affecting affect VBG cord-265279-0zjpqnqp 63 30 the the DT cord-265279-0zjpqnqp 63 31 ability ability NN cord-265279-0zjpqnqp 63 32 to to TO cord-265279-0zjpqnqp 63 33 detect detect VB cord-265279-0zjpqnqp 63 34 the the DT cord-265279-0zjpqnqp 63 35 target target NN cord-265279-0zjpqnqp 63 36 even even RB cord-265279-0zjpqnqp 63 37 when when WRB cord-265279-0zjpqnqp 63 38 present present JJ cord-265279-0zjpqnqp 63 39 in in IN cord-265279-0zjpqnqp 63 40 low low JJ cord-265279-0zjpqnqp 63 41 concentrations concentration NNS cord-265279-0zjpqnqp 63 42 , , , cord-265279-0zjpqnqp 63 43 was be VBD cord-265279-0zjpqnqp 63 44 used use VBN cord-265279-0zjpqnqp 63 45 . . . cord-265279-0zjpqnqp 64 1 The the DT cord-265279-0zjpqnqp 64 2 detection detection NN cord-265279-0zjpqnqp 64 3 of of IN cord-265279-0zjpqnqp 64 4 the the DT cord-265279-0zjpqnqp 64 5 internal internal JJ cord-265279-0zjpqnqp 64 6 control control NN cord-265279-0zjpqnqp 64 7 was be VBD cord-265279-0zjpqnqp 64 8 through through IN cord-265279-0zjpqnqp 64 9 the the DT cord-265279-0zjpqnqp 64 10 VIC VIC NNP cord-265279-0zjpqnqp 64 11 channel channel NN cord-265279-0zjpqnqp 64 12 . . . cord-265279-0zjpqnqp 65 1 Moreover moreover RB cord-265279-0zjpqnqp 65 2 , , , cord-265279-0zjpqnqp 65 3 a a DT cord-265279-0zjpqnqp 65 4 primer primer NN cord-265279-0zjpqnqp 65 5 mix mix NN cord-265279-0zjpqnqp 65 6 for for IN cord-265279-0zjpqnqp 65 7 the the DT cord-265279-0zjpqnqp 65 8 endogenous endogenous JJ cord-265279-0zjpqnqp 65 9 control control NN cord-265279-0zjpqnqp 66 1 Actin actin NN cord-265279-0zjpqnqp 66 2 Beta beta NN cord-265279-0zjpqnqp 66 3 ( ( -LRB- cord-265279-0zjpqnqp 66 4 ACTB ACTB NNP cord-265279-0zjpqnqp 66 5 ) ) -RRB- cord-265279-0zjpqnqp 66 6 gene gene NN cord-265279-0zjpqnqp 66 7 was be VBD cord-265279-0zjpqnqp 66 8 used use VBN cord-265279-0zjpqnqp 66 9 to to TO cord-265279-0zjpqnqp 66 10 evaluate evaluate VB cord-265279-0zjpqnqp 66 11 the the DT cord-265279-0zjpqnqp 66 12 quality quality NN cord-265279-0zjpqnqp 66 13 of of IN cord-265279-0zjpqnqp 66 14 the the DT cord-265279-0zjpqnqp 66 15 original original JJ cord-265279-0zjpqnqp 66 16 biological biological JJ cord-265279-0zjpqnqp 66 17 sample sample NN cord-265279-0zjpqnqp 66 18 . . . cord-265279-0zjpqnqp 67 1 The the DT cord-265279-0zjpqnqp 67 2 detection detection NN cord-265279-0zjpqnqp 67 3 of of IN cord-265279-0zjpqnqp 67 4 ACTB ACTB NNP cord-265279-0zjpqnqp 67 5 is be VBZ cord-265279-0zjpqnqp 67 6 through through IN cord-265279-0zjpqnqp 67 7 the the DT cord-265279-0zjpqnqp 67 8 VIC VIC NNP cord-265279-0zjpqnqp 67 9 channel channel NN cord-265279-0zjpqnqp 67 10 , , , cord-265279-0zjpqnqp 67 11 thus thus RB cord-265279-0zjpqnqp 67 12 a a DT cord-265279-0zjpqnqp 67 13 separate separate JJ cord-265279-0zjpqnqp 67 14 reaction reaction NN cord-265279-0zjpqnqp 67 15 mix mix NN cord-265279-0zjpqnqp 67 16 than than IN cord-265279-0zjpqnqp 67 17 that that DT cord-265279-0zjpqnqp 67 18 of of IN cord-265279-0zjpqnqp 67 19 the the DT cord-265279-0zjpqnqp 67 20 target target NN cord-265279-0zjpqnqp 67 21 is be VBZ cord-265279-0zjpqnqp 67 22 necessary necessary JJ cord-265279-0zjpqnqp 67 23 to to TO cord-265279-0zjpqnqp 67 24 test test VB cord-265279-0zjpqnqp 67 25 for for IN cord-265279-0zjpqnqp 67 26 ACTB ACTB NNP cord-265279-0zjpqnqp 67 27 as as IN cord-265279-0zjpqnqp 67 28 multiplexing multiplexe VBG cord-265279-0zjpqnqp 67 29 for for IN cord-265279-0zjpqnqp 67 30 ACTB ACTB NNP cord-265279-0zjpqnqp 67 31 and and CC cord-265279-0zjpqnqp 67 32 HCoV HCoV NNP cord-265279-0zjpqnqp 67 33 primers primer NNS cord-265279-0zjpqnqp 67 34 is be VBZ cord-265279-0zjpqnqp 67 35 not not RB cord-265279-0zjpqnqp 67 36 possible possible JJ cord-265279-0zjpqnqp 67 37 . . . cord-265279-0zjpqnqp 68 1 For for IN cord-265279-0zjpqnqp 68 2 each each DT cord-265279-0zjpqnqp 68 3 sample sample NN cord-265279-0zjpqnqp 68 4 , , , cord-265279-0zjpqnqp 68 5 three three CD cord-265279-0zjpqnqp 68 6 reaction reaction NN cord-265279-0zjpqnqp 68 7 mixes mix NNS cord-265279-0zjpqnqp 68 8 were be VBD cord-265279-0zjpqnqp 68 9 prepared prepare VBN cord-265279-0zjpqnqp 68 10 . . . cord-265279-0zjpqnqp 69 1 For for IN cord-265279-0zjpqnqp 69 2 the the DT cord-265279-0zjpqnqp 69 3 detection detection NN cord-265279-0zjpqnqp 69 4 of of IN cord-265279-0zjpqnqp 69 5 ORF1ab ORF1ab NNP cord-265279-0zjpqnqp 69 6 and and CC cord-265279-0zjpqnqp 69 7 ORF5 ORF5 NNP cord-265279-0zjpqnqp 69 8 / / SYM cord-265279-0zjpqnqp 69 9 E e NN cord-265279-0zjpqnqp 69 10 two two CD cord-265279-0zjpqnqp 69 11 20 20 CD cord-265279-0zjpqnqp 69 12 μl μl IN cord-265279-0zjpqnqp 69 13 reaction reaction NN cord-265279-0zjpqnqp 69 14 tubes tube NNS cord-265279-0zjpqnqp 69 15 were be VBD cord-265279-0zjpqnqp 69 16 prepared prepare VBN cord-265279-0zjpqnqp 69 17 as as IN cord-265279-0zjpqnqp 69 18 follows follow VBZ cord-265279-0zjpqnqp 69 19 : : : cord-265279-0zjpqnqp 70 1 10 10 CD cord-265279-0zjpqnqp 70 2 μl μl NN cord-265279-0zjpqnqp 70 3 of of IN cord-265279-0zjpqnqp 70 4 oasig oasig NNP cord-265279-0zjpqnqp 70 5 ™ ™ NNP cord-265279-0zjpqnqp 70 6 qRT qRT NNP cord-265279-0zjpqnqp 70 7 - - HYPH cord-265279-0zjpqnqp 70 8 PCR PCR NNP cord-265279-0zjpqnqp 70 9 mastermix mastermix NNP cord-265279-0zjpqnqp 70 10 , , , cord-265279-0zjpqnqp 70 11 1 1 CD cord-265279-0zjpqnqp 70 12 μl μl NN cord-265279-0zjpqnqp 70 13 of of IN cord-265279-0zjpqnqp 70 14 HCoV_2012 HCoV_2012 NNP cord-265279-0zjpqnqp 70 15 ( ( -LRB- cord-265279-0zjpqnqp 70 16 ORF1ab ORF1ab NNP cord-265279-0zjpqnqp 70 17 or or CC cord-265279-0zjpqnqp 70 18 ORF5 ORF5 NNP cord-265279-0zjpqnqp 70 19 / / SYM cord-265279-0zjpqnqp 70 20 E e NN cord-265279-0zjpqnqp 70 21 ) ) -RRB- cord-265279-0zjpqnqp 70 22 primer primer NN cord-265279-0zjpqnqp 70 23 / / SYM cord-265279-0zjpqnqp 70 24 probe probe NN cord-265279-0zjpqnqp 70 25 mix mix NN cord-265279-0zjpqnqp 70 26 , , , cord-265279-0zjpqnqp 70 27 1 1 CD cord-265279-0zjpqnqp 70 28 μl μl NN cord-265279-0zjpqnqp 70 29 of of IN cord-265279-0zjpqnqp 70 30 internal internal JJ cord-265279-0zjpqnqp 70 31 extraction extraction NN cord-265279-0zjpqnqp 70 32 control control NN cord-265279-0zjpqnqp 70 33 primer primer NN cord-265279-0zjpqnqp 70 34 / / SYM cord-265279-0zjpqnqp 70 35 probe probe NN cord-265279-0zjpqnqp 70 36 mix mix NN cord-265279-0zjpqnqp 70 37 , , , cord-265279-0zjpqnqp 70 38 6 6 CD cord-265279-0zjpqnqp 70 39 μl μl NN cord-265279-0zjpqnqp 70 40 of of IN cord-265279-0zjpqnqp 70 41 RNase RNase NNP cord-265279-0zjpqnqp 70 42 / / SYM cord-265279-0zjpqnqp 70 43 DNase DNase NNP cord-265279-0zjpqnqp 70 44 free free JJ cord-265279-0zjpqnqp 70 45 water water NN cord-265279-0zjpqnqp 70 46 and and CC cord-265279-0zjpqnqp 70 47 2 2 CD cord-265279-0zjpqnqp 70 48 μl μl NN cord-265279-0zjpqnqp 70 49 RNA RNA NNP cord-265279-0zjpqnqp 70 50 material material NN cord-265279-0zjpqnqp 70 51 . . . cord-265279-0zjpqnqp 71 1 To to TO cord-265279-0zjpqnqp 71 2 detect detect VB cord-265279-0zjpqnqp 71 3 the the DT cord-265279-0zjpqnqp 71 4 endogenous endogenous JJ cord-265279-0zjpqnqp 71 5 ACTB ACTB NNP cord-265279-0zjpqnqp 71 6 control control NN cord-265279-0zjpqnqp 71 7 , , , cord-265279-0zjpqnqp 71 8 a a DT cord-265279-0zjpqnqp 71 9 separate separate JJ cord-265279-0zjpqnqp 71 10 20 20 CD cord-265279-0zjpqnqp 71 11 μl μl IN cord-265279-0zjpqnqp 71 12 reaction reaction NN cord-265279-0zjpqnqp 71 13 mix mix NN cord-265279-0zjpqnqp 71 14 was be VBD cord-265279-0zjpqnqp 71 15 prepared prepare VBN cord-265279-0zjpqnqp 71 16 , , , cord-265279-0zjpqnqp 71 17 containing contain VBG cord-265279-0zjpqnqp 71 18 , , , cord-265279-0zjpqnqp 72 1 10 10 CD cord-265279-0zjpqnqp 72 2 μl μl NN cord-265279-0zjpqnqp 72 3 of of IN cord-265279-0zjpqnqp 72 4 oasig oasig NNP cord-265279-0zjpqnqp 72 5 ™ ™ NNP cord-265279-0zjpqnqp 72 6 qRT qRT NNP cord-265279-0zjpqnqp 72 7 - - HYPH cord-265279-0zjpqnqp 72 8 PCR PCR NNP cord-265279-0zjpqnqp 72 9 mastermix mastermix NN cord-265279-0zjpqnqp 72 10 , , , cord-265279-0zjpqnqp 73 1 1 1 CD cord-265279-0zjpqnqp 73 2 μl μl NN cord-265279-0zjpqnqp 73 3 of of IN cord-265279-0zjpqnqp 73 4 endogenous endogenous JJ cord-265279-0zjpqnqp 73 5 ACTB ACTB NNP cord-265279-0zjpqnqp 73 6 primer primer NN cord-265279-0zjpqnqp 73 7 / / SYM cord-265279-0zjpqnqp 73 8 probe probe NN cord-265279-0zjpqnqp 73 9 mix mix NN cord-265279-0zjpqnqp 73 10 , , , cord-265279-0zjpqnqp 73 11 7 7 CD cord-265279-0zjpqnqp 73 12 μl μl NN cord-265279-0zjpqnqp 73 13 of of IN cord-265279-0zjpqnqp 73 14 RNase RNase NNP cord-265279-0zjpqnqp 73 15 / / SYM cord-265279-0zjpqnqp 73 16 DNase DNase NNP cord-265279-0zjpqnqp 73 17 free free JJ cord-265279-0zjpqnqp 73 18 water water NN cord-265279-0zjpqnqp 73 19 and and CC cord-265279-0zjpqnqp 73 20 2 2 CD cord-265279-0zjpqnqp 73 21 μl μl NN cord-265279-0zjpqnqp 73 22 RNA RNA NNP cord-265279-0zjpqnqp 73 23 material material NN cord-265279-0zjpqnqp 73 24 . . . cord-265279-0zjpqnqp 74 1 The the DT cord-265279-0zjpqnqp 74 2 amplification amplification NN cord-265279-0zjpqnqp 74 3 conditions condition NNS cord-265279-0zjpqnqp 74 4 involved involve VBD cord-265279-0zjpqnqp 74 5 a a DT cord-265279-0zjpqnqp 74 6 reverse reverse JJ cord-265279-0zjpqnqp 74 7 transcription transcription NN cord-265279-0zjpqnqp 74 8 step step NN cord-265279-0zjpqnqp 74 9 at at IN cord-265279-0zjpqnqp 74 10 42 42 CD cord-265279-0zjpqnqp 74 11 ° ° NN cord-265279-0zjpqnqp 74 12 C c NN cord-265279-0zjpqnqp 74 13 for for IN cord-265279-0zjpqnqp 74 14 10 10 CD cord-265279-0zjpqnqp 74 15 min min NN cord-265279-0zjpqnqp 74 16 , , , cord-265279-0zjpqnqp 74 17 an an DT cord-265279-0zjpqnqp 74 18 enzyme enzyme NN cord-265279-0zjpqnqp 74 19 activation activation NN cord-265279-0zjpqnqp 74 20 step step NN cord-265279-0zjpqnqp 74 21 at at IN cord-265279-0zjpqnqp 74 22 95 95 CD cord-265279-0zjpqnqp 74 23 ° ° NN cord-265279-0zjpqnqp 74 24 C c NN cord-265279-0zjpqnqp 74 25 for for IN cord-265279-0zjpqnqp 74 26 2 2 CD cord-265279-0zjpqnqp 74 27 min min NN cord-265279-0zjpqnqp 74 28 and and CC cord-265279-0zjpqnqp 74 29 50 50 CD cord-265279-0zjpqnqp 74 30 cycles cycle NNS cord-265279-0zjpqnqp 74 31 of of IN cord-265279-0zjpqnqp 74 32 95 95 CD cord-265279-0zjpqnqp 74 33 ° ° NN cord-265279-0zjpqnqp 74 34 C c NN cord-265279-0zjpqnqp 74 35 for for IN cord-265279-0zjpqnqp 74 36 10 10 CD cord-265279-0zjpqnqp 74 37 s s NNS cord-265279-0zjpqnqp 74 38 followed follow VBN cord-265279-0zjpqnqp 74 39 by by IN cord-265279-0zjpqnqp 74 40 60 60 CD cord-265279-0zjpqnqp 74 41 ° ° NN cord-265279-0zjpqnqp 74 42 C c NN cord-265279-0zjpqnqp 74 43 for for IN cord-265279-0zjpqnqp 74 44 60 60 CD cord-265279-0zjpqnqp 75 1 s. s. NNP cord-265279-0zjpqnqp 75 2 A a DT cord-265279-0zjpqnqp 75 3 positive positive JJ cord-265279-0zjpqnqp 75 4 control control NN cord-265279-0zjpqnqp 75 5 for for IN cord-265279-0zjpqnqp 75 6 ORF1ab ORF1ab NNP cord-265279-0zjpqnqp 75 7 and and CC cord-265279-0zjpqnqp 75 8 ORF5 ORF5 NNP cord-265279-0zjpqnqp 75 9 / / SYM cord-265279-0zjpqnqp 75 10 E e NN cord-265279-0zjpqnqp 75 11 , , , cord-265279-0zjpqnqp 75 12 as as RB cord-265279-0zjpqnqp 75 13 well well RB cord-265279-0zjpqnqp 75 14 as as IN cord-265279-0zjpqnqp 75 15 a a DT cord-265279-0zjpqnqp 75 16 negative negative JJ cord-265279-0zjpqnqp 75 17 control control NN cord-265279-0zjpqnqp 75 18 ( ( -LRB- cord-265279-0zjpqnqp 75 19 RNase RNase NNP cord-265279-0zjpqnqp 75 20 / / SYM cord-265279-0zjpqnqp 75 21 DNase DNase NNP cord-265279-0zjpqnqp 75 22 free free JJ cord-265279-0zjpqnqp 75 23 water water NN cord-265279-0zjpqnqp 75 24 ) ) -RRB- cord-265279-0zjpqnqp 75 25 was be VBD cord-265279-0zjpqnqp 75 26 used use VBN cord-265279-0zjpqnqp 75 27 with with IN cord-265279-0zjpqnqp 75 28 each each DT cord-265279-0zjpqnqp 75 29 run run NN cord-265279-0zjpqnqp 75 30 . . . cord-265279-0zjpqnqp 76 1 The the DT cord-265279-0zjpqnqp 76 2 test test NN cord-265279-0zjpqnqp 76 3 requires require VBZ cord-265279-0zjpqnqp 76 4 65 65 CD cord-265279-0zjpqnqp 76 5 min min NN cord-265279-0zjpqnqp 76 6 hands hand NNS cord-265279-0zjpqnqp 76 7 - - HYPH cord-265279-0zjpqnqp 76 8 on on RP cord-265279-0zjpqnqp 76 9 time time NN cord-265279-0zjpqnqp 76 10 and and CC cord-265279-0zjpqnqp 76 11 the the DT cord-265279-0zjpqnqp 76 12 PCR PCR NNP cord-265279-0zjpqnqp 76 13 protocol protocol NN cord-265279-0zjpqnqp 76 14 lasts last VBZ cord-265279-0zjpqnqp 76 15 two two CD cord-265279-0zjpqnqp 76 16 hours hour NNS cord-265279-0zjpqnqp 76 17 after after IN cord-265279-0zjpqnqp 76 18 which which WDT cord-265279-0zjpqnqp 76 19 the the DT cord-265279-0zjpqnqp 76 20 ROTORGENE ROTORGENE NNP cord-265279-0zjpqnqp 76 21 - - HYPH cord-265279-0zjpqnqp 76 22 Q Q NNP cord-265279-0zjpqnqp 76 23 ( ( -LRB- cord-265279-0zjpqnqp 76 24 Qiagen Qiagen NNP cord-265279-0zjpqnqp 76 25 , , , cord-265279-0zjpqnqp 76 26 UK UK NNP cord-265279-0zjpqnqp 76 27 ) ) -RRB- cord-265279-0zjpqnqp 76 28 Software Software NNP cord-265279-0zjpqnqp 76 29 is be VBZ cord-265279-0zjpqnqp 76 30 used use VBN cord-265279-0zjpqnqp 76 31 for for IN cord-265279-0zjpqnqp 76 32 analysis analysis NN cord-265279-0zjpqnqp 76 33 . . . cord-265279-0zjpqnqp 77 1 Out out IN cord-265279-0zjpqnqp 77 2 of of IN cord-265279-0zjpqnqp 77 3 the the DT cord-265279-0zjpqnqp 77 4 46 46 CD cord-265279-0zjpqnqp 77 5 tested test VBN cord-265279-0zjpqnqp 77 6 samples sample NNS cord-265279-0zjpqnqp 77 7 , , , cord-265279-0zjpqnqp 77 8 45 45 CD cord-265279-0zjpqnqp 77 9 were be VBD cord-265279-0zjpqnqp 77 10 negative negative JJ cord-265279-0zjpqnqp 77 11 for for IN cord-265279-0zjpqnqp 77 12 MERS MERS NNP cord-265279-0zjpqnqp 77 13 - - HYPH cord-265279-0zjpqnqp 77 14 CoV CoV NNP cord-265279-0zjpqnqp 77 15 and and CC cord-265279-0zjpqnqp 77 16 one one CD cord-265279-0zjpqnqp 77 17 sample sample NN cord-265279-0zjpqnqp 77 18 was be VBD cord-265279-0zjpqnqp 77 19 found find VBN cord-265279-0zjpqnqp 77 20 MERS MERS NNP cord-265279-0zjpqnqp 77 21 - - HYPH cord-265279-0zjpqnqp 77 22 CoV CoV NNP cord-265279-0zjpqnqp 77 23 positive positive JJ cord-265279-0zjpqnqp 77 24 . . . cord-265279-0zjpqnqp 78 1 The the DT cord-265279-0zjpqnqp 78 2 positive positive JJ cord-265279-0zjpqnqp 78 3 result result NN cord-265279-0zjpqnqp 78 4 was be VBD cord-265279-0zjpqnqp 78 5 validated validate VBN cord-265279-0zjpqnqp 78 6 by by IN cord-265279-0zjpqnqp 78 7 the the DT cord-265279-0zjpqnqp 78 8 Naval Naval NNP cord-265279-0zjpqnqp 78 9 Medical Medical NNP cord-265279-0zjpqnqp 78 10 Research Research NNP cord-265279-0zjpqnqp 78 11 Unit Unit NNP cord-265279-0zjpqnqp 78 12 ( ( -LRB- cord-265279-0zjpqnqp 78 13 NAMRU NAMRU NNP cord-265279-0zjpqnqp 78 14 ) ) -RRB- cord-265279-0zjpqnqp 78 15 laboratory laboratory NN cord-265279-0zjpqnqp 78 16 , , , cord-265279-0zjpqnqp 78 17 located locate VBN cord-265279-0zjpqnqp 78 18 in in IN cord-265279-0zjpqnqp 78 19 Cairo Cairo NNP cord-265279-0zjpqnqp 78 20 - - HYPH cord-265279-0zjpqnqp 78 21 Egypt Egypt NNP cord-265279-0zjpqnqp 78 22 , , , cord-265279-0zjpqnqp 78 23 in in IN cord-265279-0zjpqnqp 78 24 collaboration collaboration NN cord-265279-0zjpqnqp 78 25 with with IN cord-265279-0zjpqnqp 78 26 the the DT cord-265279-0zjpqnqp 78 27 World World NNP cord-265279-0zjpqnqp 78 28 Health Health NNP cord-265279-0zjpqnqp 78 29 Organization Organization NNP cord-265279-0zjpqnqp 78 30 ( ( -LRB- cord-265279-0zjpqnqp 78 31 WHO who WP cord-265279-0zjpqnqp 78 32 ) ) -RRB- cord-265279-0zjpqnqp 78 33 . . . cord-265279-0zjpqnqp 79 1 All all DT cord-265279-0zjpqnqp 79 2 other other JJ cord-265279-0zjpqnqp 79 3 results result NNS cord-265279-0zjpqnqp 79 4 were be VBD cord-265279-0zjpqnqp 79 5 validated validate VBN cord-265279-0zjpqnqp 79 6 with with IN cord-265279-0zjpqnqp 79 7 a a DT cord-265279-0zjpqnqp 79 8 CAP cap NN cord-265279-0zjpqnqp 79 9 accredited accredit VBN cord-265279-0zjpqnqp 79 10 referral referral JJ cord-265279-0zjpqnqp 79 11 laboratory laboratory NN cord-265279-0zjpqnqp 79 12 in in IN cord-265279-0zjpqnqp 79 13 Germany Germany NNP cord-265279-0zjpqnqp 79 14 and and CC cord-265279-0zjpqnqp 79 15 the the DT cord-265279-0zjpqnqp 79 16 concordance concordance NN cord-265279-0zjpqnqp 79 17 rate rate NN cord-265279-0zjpqnqp 79 18 was be VBD cord-265279-0zjpqnqp 79 19 100 100 CD cord-265279-0zjpqnqp 79 20 % % NN cord-265279-0zjpqnqp 79 21 . . . cord-265279-0zjpqnqp 80 1 Fig Fig NNP cord-265279-0zjpqnqp 80 2 . . NNP cord-265279-0zjpqnqp 80 3 1 1 CD cord-265279-0zjpqnqp 80 4 represents represent VBZ cord-265279-0zjpqnqp 80 5 a a DT cord-265279-0zjpqnqp 80 6 graph graph NN cord-265279-0zjpqnqp 80 7 of of IN cord-265279-0zjpqnqp 80 8 the the DT cord-265279-0zjpqnqp 80 9 amplification amplification NN cord-265279-0zjpqnqp 80 10 of of IN cord-265279-0zjpqnqp 80 11 the the DT cord-265279-0zjpqnqp 80 12 MERS MERS NNP cord-265279-0zjpqnqp 80 13 - - HYPH cord-265279-0zjpqnqp 80 14 CoV CoV NNP cord-265279-0zjpqnqp 80 15 RNA RNA NNP cord-265279-0zjpqnqp 80 16 and and CC cord-265279-0zjpqnqp 80 17 the the DT cord-265279-0zjpqnqp 80 18 endogenous endogenous JJ cord-265279-0zjpqnqp 80 19 ACTB ACTB NNP cord-265279-0zjpqnqp 80 20 in in IN cord-265279-0zjpqnqp 80 21 the the DT cord-265279-0zjpqnqp 80 22 MERS MERS NNP cord-265279-0zjpqnqp 80 23 - - HYPH cord-265279-0zjpqnqp 80 24 CoV CoV NNP cord-265279-0zjpqnqp 80 25 positive positive JJ cord-265279-0zjpqnqp 80 26 sample sample NN cord-265279-0zjpqnqp 80 27 . . . cord-265279-0zjpqnqp 81 1 Positive positive JJ cord-265279-0zjpqnqp 81 2 and and CC cord-265279-0zjpqnqp 81 3 negative negative JJ cord-265279-0zjpqnqp 81 4 controls control NNS cord-265279-0zjpqnqp 81 5 were be VBD cord-265279-0zjpqnqp 81 6 used use VBN cord-265279-0zjpqnqp 81 7 and and CC cord-265279-0zjpqnqp 81 8 signal signal JJ cord-265279-0zjpqnqp 81 9 detection detection NN cord-265279-0zjpqnqp 81 10 was be VBD cord-265279-0zjpqnqp 81 11 done do VBN cord-265279-0zjpqnqp 81 12 on on IN cord-265279-0zjpqnqp 81 13 the the DT cord-265279-0zjpqnqp 81 14 FAM FAM NNP cord-265279-0zjpqnqp 81 15 channel channel NN cord-265279-0zjpqnqp 81 16 . . . cord-265279-0zjpqnqp 82 1 The the DT cord-265279-0zjpqnqp 82 2 graph graph NN cord-265279-0zjpqnqp 82 3 in in IN cord-265279-0zjpqnqp 82 4 Fig Fig NNP cord-265279-0zjpqnqp 82 5 . . . cord-265279-0zjpqnqp 83 1 2 2 CD cord-265279-0zjpqnqp 83 2 represents represent VBZ cord-265279-0zjpqnqp 83 3 the the DT cord-265279-0zjpqnqp 83 4 detection detection NN cord-265279-0zjpqnqp 83 5 of of IN cord-265279-0zjpqnqp 83 6 the the DT cord-265279-0zjpqnqp 83 7 internal internal JJ cord-265279-0zjpqnqp 83 8 RNA RNA NNP cord-265279-0zjpqnqp 83 9 extraction extraction NN cord-265279-0zjpqnqp 83 10 control control NN cord-265279-0zjpqnqp 83 11 ( ( -LRB- cord-265279-0zjpqnqp 83 12 IEC IEC NNP cord-265279-0zjpqnqp 83 13 ) ) -RRB- cord-265279-0zjpqnqp 83 14 in in IN cord-265279-0zjpqnqp 83 15 the the DT cord-265279-0zjpqnqp 83 16 fluorescence fluorescence NN cord-265279-0zjpqnqp 83 17 channel channel NN cord-265279-0zjpqnqp 83 18 VIC VIC NNP cord-265279-0zjpqnqp 83 19 , , , cord-265279-0zjpqnqp 83 20 for for IN cord-265279-0zjpqnqp 83 21 the the DT cord-265279-0zjpqnqp 83 22 same same JJ cord-265279-0zjpqnqp 83 23 positive positive JJ cord-265279-0zjpqnqp 83 24 sample sample NN cord-265279-0zjpqnqp 83 25 . . . cord-265279-0zjpqnqp 84 1 IEC IEC NNP cord-265279-0zjpqnqp 84 2 was be VBD cord-265279-0zjpqnqp 84 3 only only RB cord-265279-0zjpqnqp 84 4 added add VBN cord-265279-0zjpqnqp 84 5 to to IN cord-265279-0zjpqnqp 84 6 the the DT cord-265279-0zjpqnqp 84 7 sample sample NN cord-265279-0zjpqnqp 84 8 during during IN cord-265279-0zjpqnqp 84 9 extraction extraction NN cord-265279-0zjpqnqp 84 10 and and CC cord-265279-0zjpqnqp 84 11 not not RB cord-265279-0zjpqnqp 84 12 to to IN cord-265279-0zjpqnqp 84 13 the the DT cord-265279-0zjpqnqp 84 14 positive positive JJ cord-265279-0zjpqnqp 84 15 or or CC cord-265279-0zjpqnqp 84 16 negative negative JJ cord-265279-0zjpqnqp 84 17 controls control NNS cord-265279-0zjpqnqp 84 18 . . . cord-265279-0zjpqnqp 85 1 An an DT cord-265279-0zjpqnqp 85 2 acceptable acceptable JJ cord-265279-0zjpqnqp 85 3 Ct ct JJ cord-265279-0zjpqnqp 85 4 value value NN cord-265279-0zjpqnqp 85 5 of of IN cord-265279-0zjpqnqp 85 6 the the DT cord-265279-0zjpqnqp 85 7 IEC IEC NNP cord-265279-0zjpqnqp 85 8 ranges range NNS cord-265279-0zjpqnqp 85 9 between between IN cord-265279-0zjpqnqp 85 10 28 28 CD cord-265279-0zjpqnqp 85 11 and and CC cord-265279-0zjpqnqp 85 12 34 34 CD cord-265279-0zjpqnqp 85 13 . . . cord-265279-0zjpqnqp 86 1 The the DT cord-265279-0zjpqnqp 86 2 GeneSig GeneSig NNP cord-265279-0zjpqnqp 86 3 Human Human NNP cord-265279-0zjpqnqp 86 4 Coronavirus Coronavirus NNP cord-265279-0zjpqnqp 86 5 2012 2012 CD cord-265279-0zjpqnqp 86 6 ( ( -LRB- cord-265279-0zjpqnqp 86 7 MERS MERS NNP cord-265279-0zjpqnqp 86 8 ) ) -RRB- cord-265279-0zjpqnqp 86 9 kit kit NN cord-265279-0zjpqnqp 86 10 is be VBZ cord-265279-0zjpqnqp 86 11 a a DT cord-265279-0zjpqnqp 86 12 rapid rapid JJ cord-265279-0zjpqnqp 86 13 and and CC cord-265279-0zjpqnqp 86 14 useful useful JJ cord-265279-0zjpqnqp 86 15 kit kit NN cord-265279-0zjpqnqp 86 16 for for IN cord-265279-0zjpqnqp 86 17 the the DT cord-265279-0zjpqnqp 86 18 screening screening NN cord-265279-0zjpqnqp 86 19 of of IN cord-265279-0zjpqnqp 86 20 suspected suspect VBN cord-265279-0zjpqnqp 86 21 respiratory respiratory JJ cord-265279-0zjpqnqp 86 22 cases case NNS cord-265279-0zjpqnqp 86 23 in in IN cord-265279-0zjpqnqp 86 24 the the DT cord-265279-0zjpqnqp 86 25 Middle Middle NNP cord-265279-0zjpqnqp 86 26 East East NNP cord-265279-0zjpqnqp 86 27 area area NN cord-265279-0zjpqnqp 86 28 as as RB cord-265279-0zjpqnqp 86 29 well well RB cord-265279-0zjpqnqp 86 30 as as IN cord-265279-0zjpqnqp 86 31 other other JJ cord-265279-0zjpqnqp 86 32 regions region NNS cord-265279-0zjpqnqp 86 33 . . . cord-265279-0zjpqnqp 87 1 The the DT cord-265279-0zjpqnqp 87 2 collaboration collaboration NN cord-265279-0zjpqnqp 87 3 of of IN cord-265279-0zjpqnqp 87 4 different different JJ cord-265279-0zjpqnqp 87 5 molecular molecular JJ cord-265279-0zjpqnqp 87 6 microbiology microbiology NN cord-265279-0zjpqnqp 87 7 laboratories laboratory NNS cord-265279-0zjpqnqp 87 8 with with IN cord-265279-0zjpqnqp 87 9 the the DT cord-265279-0zjpqnqp 87 10 World World NNP cord-265279-0zjpqnqp 87 11 Health Health NNP cord-265279-0zjpqnqp 87 12 Organization Organization NNP cord-265279-0zjpqnqp 87 13 ( ( -LRB- cord-265279-0zjpqnqp 87 14 with with IN cord-265279-0zjpqnqp 87 15 viral viral JJ cord-265279-0zjpqnqp 87 16 cultures culture NNS cord-265279-0zjpqnqp 87 17 done do VBN cord-265279-0zjpqnqp 87 18 as as IN cord-265279-0zjpqnqp 87 19 gold gold JJ cord-265279-0zjpqnqp 87 20 standard standard JJ cord-265279-0zjpqnqp 87 21 reference reference NN cord-265279-0zjpqnqp 87 22 testing testing NN cord-265279-0zjpqnqp 87 23 ) ) -RRB- cord-265279-0zjpqnqp 87 24 has have VBZ cord-265279-0zjpqnqp 87 25 always always RB cord-265279-0zjpqnqp 87 26 been be VBN cord-265279-0zjpqnqp 87 27 a a DT cord-265279-0zjpqnqp 87 28 rewarding rewarding JJ cord-265279-0zjpqnqp 87 29 and and CC cord-265279-0zjpqnqp 87 30 teaching teaching NN cord-265279-0zjpqnqp 87 31 experience experience NN cord-265279-0zjpqnqp 87 32 . . . cord-265279-0zjpqnqp 88 1 No no DT cord-265279-0zjpqnqp 88 2 extensive extensive JJ cord-265279-0zjpqnqp 88 3 sensitivity sensitivity NN cord-265279-0zjpqnqp 88 4 and and CC cord-265279-0zjpqnqp 88 5 specificity specificity NN cord-265279-0zjpqnqp 88 6 work work NN cord-265279-0zjpqnqp 88 7 - - HYPH cord-265279-0zjpqnqp 88 8 up up NN cord-265279-0zjpqnqp 88 9 has have VBZ cord-265279-0zjpqnqp 88 10 been be VBN cord-265279-0zjpqnqp 88 11 performed perform VBN cord-265279-0zjpqnqp 88 12 from from IN cord-265279-0zjpqnqp 88 13 our -PRON- PRP$ cord-265279-0zjpqnqp 88 14 side side NN cord-265279-0zjpqnqp 88 15 on on IN cord-265279-0zjpqnqp 88 16 multiple multiple JJ cord-265279-0zjpqnqp 88 17 samples sample NNS cord-265279-0zjpqnqp 88 18 due due JJ cord-265279-0zjpqnqp 88 19 to to IN cord-265279-0zjpqnqp 88 20 the the DT cord-265279-0zjpqnqp 88 21 presence presence NN cord-265279-0zjpqnqp 88 22 of of IN cord-265279-0zjpqnqp 88 23 a a DT cord-265279-0zjpqnqp 88 24 single single JJ cord-265279-0zjpqnqp 88 25 MERS MERS NNP cord-265279-0zjpqnqp 88 26 - - HYPH cord-265279-0zjpqnqp 88 27 CoV CoV NNP cord-265279-0zjpqnqp 88 28 positive positive JJ cord-265279-0zjpqnqp 88 29 case case NN cord-265279-0zjpqnqp 88 30 ; ; : cord-265279-0zjpqnqp 88 31 however however RB cord-265279-0zjpqnqp 88 32 , , , cord-265279-0zjpqnqp 88 33 our -PRON- PRP$ cord-265279-0zjpqnqp 88 34 lower low JJR cord-265279-0zjpqnqp 88 35 limit limit NN cord-265279-0zjpqnqp 88 36 of of IN cord-265279-0zjpqnqp 88 37 detection detection NN cord-265279-0zjpqnqp 88 38 is be VBZ cord-265279-0zjpqnqp 88 39 compatible compatible JJ cord-265279-0zjpqnqp 88 40 with with IN cord-265279-0zjpqnqp 88 41 the the DT cord-265279-0zjpqnqp 88 42 100 100 CD cord-265279-0zjpqnqp 88 43 copies copy NNS cord-265279-0zjpqnqp 88 44 / / SYM cord-265279-0zjpqnqp 88 45 ml ml NNS cord-265279-0zjpqnqp 88 46 reported report VBN cord-265279-0zjpqnqp 88 47 by by IN cord-265279-0zjpqnqp 88 48 the the DT cord-265279-0zjpqnqp 88 49 manufacturer manufacturer NN cord-265279-0zjpqnqp 88 50 . . . cord-265279-0zjpqnqp 89 1 The the DT cord-265279-0zjpqnqp 89 2 clinicians clinician NNS cord-265279-0zjpqnqp 89 3 have have VBP cord-265279-0zjpqnqp 89 4 advised advise VBN cord-265279-0zjpqnqp 89 5 that that IN cord-265279-0zjpqnqp 89 6 this this DT cord-265279-0zjpqnqp 89 7 detection detection NN cord-265279-0zjpqnqp 89 8 limit limit NN cord-265279-0zjpqnqp 89 9 is be VBZ cord-265279-0zjpqnqp 89 10 acceptable acceptable JJ cord-265279-0zjpqnqp 89 11 for for IN cord-265279-0zjpqnqp 89 12 their -PRON- PRP$ cord-265279-0zjpqnqp 89 13 management management NN cord-265279-0zjpqnqp 89 14 algorithms algorithm NNS cord-265279-0zjpqnqp 89 15 . . . cord-265279-0zjpqnqp 90 1 To to IN cord-265279-0zjpqnqp 90 2 our -PRON- PRP$ cord-265279-0zjpqnqp 90 3 knowledge knowledge NN cord-265279-0zjpqnqp 90 4 , , , cord-265279-0zjpqnqp 90 5 this this DT cord-265279-0zjpqnqp 90 6 is be VBZ cord-265279-0zjpqnqp 90 7 the the DT cord-265279-0zjpqnqp 90 8 first first JJ cord-265279-0zjpqnqp 90 9 report report NN cord-265279-0zjpqnqp 90 10 that that WDT cord-265279-0zjpqnqp 90 11 describes describe VBZ cord-265279-0zjpqnqp 90 12 the the DT cord-265279-0zjpqnqp 90 13 clinical clinical JJ cord-265279-0zjpqnqp 90 14 application application NN cord-265279-0zjpqnqp 90 15 of of IN cord-265279-0zjpqnqp 90 16 the the DT cord-265279-0zjpqnqp 90 17 GeneSig GeneSig NNP cord-265279-0zjpqnqp 90 18 kit kit NN cord-265279-0zjpqnqp 90 19 in in IN cord-265279-0zjpqnqp 90 20 the the DT cord-265279-0zjpqnqp 90 21 MERS MERS NNP cord-265279-0zjpqnqp 90 22 - - HYPH cord-265279-0zjpqnqp 90 23 CoV CoV NNP cord-265279-0zjpqnqp 90 24 epidemic epidemic NN cord-265279-0zjpqnqp 90 25 era era NN cord-265279-0zjpqnqp 90 26 . . . cord-265279-0zjpqnqp 91 1 Hospital hospital NN cord-265279-0zjpqnqp 91 2 - - HYPH cord-265279-0zjpqnqp 91 3 associated associate VBN cord-265279-0zjpqnqp 91 4 outbreak outbreak NN cord-265279-0zjpqnqp 91 5 of of IN cord-265279-0zjpqnqp 91 6 Middle Middle NNP cord-265279-0zjpqnqp 91 7 East East NNP cord-265279-0zjpqnqp 91 8 Respiratory Respiratory NNP cord-265279-0zjpqnqp 91 9 Syndrome Syndrome NNP cord-265279-0zjpqnqp 91 10 Coronavirus Coronavirus NNP cord-265279-0zjpqnqp 91 11 : : : cord-265279-0zjpqnqp 91 12 a a DT cord-265279-0zjpqnqp 91 13 serologic serologic NN cord-265279-0zjpqnqp 91 14 , , , cord-265279-0zjpqnqp 91 15 epidemiologic epidemiologic JJ cord-265279-0zjpqnqp 91 16 , , , cord-265279-0zjpqnqp 91 17 and and CC cord-265279-0zjpqnqp 91 18 clinical clinical JJ cord-265279-0zjpqnqp 91 19 description description NN cord-265279-0zjpqnqp 91 20 Epidemiological epidemiological JJ cord-265279-0zjpqnqp 91 21 , , , cord-265279-0zjpqnqp 91 22 demographic demographic JJ cord-265279-0zjpqnqp 91 23 , , , cord-265279-0zjpqnqp 91 24 and and CC cord-265279-0zjpqnqp 91 25 clinical clinical JJ cord-265279-0zjpqnqp 91 26 characteristics characteristic NNS cord-265279-0zjpqnqp 91 27 of of IN cord-265279-0zjpqnqp 91 28 47 47 CD cord-265279-0zjpqnqp 91 29 cases case NNS cord-265279-0zjpqnqp 91 30 of of IN cord-265279-0zjpqnqp 91 31 Middle Middle NNP cord-265279-0zjpqnqp 91 32 East East NNP cord-265279-0zjpqnqp 91 33 respiratory respiratory JJ cord-265279-0zjpqnqp 91 34 syndrome syndrome NN cord-265279-0zjpqnqp 91 35 coronavirus coronavirus NN cord-265279-0zjpqnqp 91 36 disease disease NN cord-265279-0zjpqnqp 91 37 from from IN cord-265279-0zjpqnqp 91 38 Saudi Saudi NNP cord-265279-0zjpqnqp 91 39 Arabia Arabia NNP cord-265279-0zjpqnqp 91 40 : : : cord-265279-0zjpqnqp 91 41 a a DT cord-265279-0zjpqnqp 91 42 descriptive descriptive JJ cord-265279-0zjpqnqp 91 43 study study NN cord-265279-0zjpqnqp 91 44 Update update NN cord-265279-0zjpqnqp 91 45 : : : cord-265279-0zjpqnqp 91 46 Severe severe JJ cord-265279-0zjpqnqp 91 47 respiratory respiratory JJ cord-265279-0zjpqnqp 91 48 illness illness NN cord-265279-0zjpqnqp 91 49 associated associate VBN cord-265279-0zjpqnqp 91 50 with with IN cord-265279-0zjpqnqp 91 51 Middle Middle NNP cord-265279-0zjpqnqp 91 52 East East NNP cord-265279-0zjpqnqp 91 53 respiratory respiratory JJ cord-265279-0zjpqnqp 91 54 syndrome syndrome NN cord-265279-0zjpqnqp 91 55 coronavirus coronavirus NN cord-265279-0zjpqnqp 91 56 ( ( -LRB- cord-265279-0zjpqnqp 91 57 MERS MERS NNP cord-265279-0zjpqnqp 91 58 - - HYPH cord-265279-0zjpqnqp 91 59 CoV)-worldwide CoV)-worldwide NNP cord-265279-0zjpqnqp 91 60 Transmission Transmission NNP cord-265279-0zjpqnqp 91 61 of of IN cord-265279-0zjpqnqp 91 62 MERS MERS NNP cord-265279-0zjpqnqp 91 63 - - HYPH cord-265279-0zjpqnqp 91 64 coronavirus coronavirus NN cord-265279-0zjpqnqp 91 65 in in IN cord-265279-0zjpqnqp 91 66 household household NN cord-265279-0zjpqnqp 91 67 contacts contact NNS cord-265279-0zjpqnqp 91 68 Molecular molecular JJ cord-265279-0zjpqnqp 91 69 pathology pathology NN cord-265279-0zjpqnqp 91 70 of of IN cord-265279-0zjpqnqp 91 71 emerging emerge VBG cord-265279-0zjpqnqp 91 72 coronavirus coronavirus NN cord-265279-0zjpqnqp 91 73 infections infection NNS cord-265279-0zjpqnqp 91 74 Real real JJ cord-265279-0zjpqnqp 91 75 - - HYPH cord-265279-0zjpqnqp 91 76 time time NN cord-265279-0zjpqnqp 91 77 reverse reverse NN cord-265279-0zjpqnqp 91 78 transcription transcription NN cord-265279-0zjpqnqp 91 79 - - HYPH cord-265279-0zjpqnqp 91 80 PCR pcr NN cord-265279-0zjpqnqp 91 81 assay assay NN cord-265279-0zjpqnqp 91 82 panel panel NN cord-265279-0zjpqnqp 91 83 for for IN cord-265279-0zjpqnqp 91 84 Middle Middle NNP cord-265279-0zjpqnqp 91 85 East East NNP cord-265279-0zjpqnqp 91 86 respiratory respiratory JJ cord-265279-0zjpqnqp 91 87 syndrome syndrome NN cord-265279-0zjpqnqp 91 88 coronavirus coronavirus NN cord-265279-0zjpqnqp 91 89 Human human JJ cord-265279-0zjpqnqp 91 90 infection infection NN cord-265279-0zjpqnqp 91 91 with with IN cord-265279-0zjpqnqp 91 92 MERS MERS NNP cord-265279-0zjpqnqp 91 93 coronavirus coronavirus NN cord-265279-0zjpqnqp 91 94 after after IN cord-265279-0zjpqnqp 91 95 exposure exposure NN cord-265279-0zjpqnqp 91 96 to to IN cord-265279-0zjpqnqp 91 97 infected infected JJ cord-265279-0zjpqnqp 91 98 camels camel NNS cord-265279-0zjpqnqp 91 99 , , , cord-265279-0zjpqnqp 91 100 Saudi Saudi NNP cord-265279-0zjpqnqp 91 101 Arabia Arabia NNP cord-265279-0zjpqnqp 91 102 Inhibition Inhibition NNP cord-265279-0zjpqnqp 91 103 of of IN cord-265279-0zjpqnqp 91 104 Middle Middle NNP cord-265279-0zjpqnqp 91 105 East East NNP cord-265279-0zjpqnqp 91 106 respiratory respiratory JJ cord-265279-0zjpqnqp 91 107 syndrome syndrome NN cord-265279-0zjpqnqp 91 108 coronavirus coronavirus NN cord-265279-0zjpqnqp 91 109 infection infection NN cord-265279-0zjpqnqp 91 110 by by IN cord-265279-0zjpqnqp 91 111 anti anti JJ cord-265279-0zjpqnqp 91 112 - - JJ cord-265279-0zjpqnqp 91 113 CD26 cd26 JJ cord-265279-0zjpqnqp 91 114 monoclonal monoclonal JJ cord-265279-0zjpqnqp 91 115 antibody antibody NN cord-265279-0zjpqnqp 92 1 A a DT cord-265279-0zjpqnqp 92 2 family family NN cord-265279-0zjpqnqp 92 3 cluster cluster NN cord-265279-0zjpqnqp 92 4 of of IN cord-265279-0zjpqnqp 92 5 Middle Middle NNP cord-265279-0zjpqnqp 92 6 East East NNP cord-265279-0zjpqnqp 92 7 respiratory respiratory JJ cord-265279-0zjpqnqp 92 8 syndrome syndrome NN cord-265279-0zjpqnqp 92 9 coronavirus coronavirus NN cord-265279-0zjpqnqp 92 10 infections infection NNS cord-265279-0zjpqnqp 92 11 related relate VBN cord-265279-0zjpqnqp 92 12 to to IN cord-265279-0zjpqnqp 92 13 a a DT cord-265279-0zjpqnqp 92 14 likely likely RB cord-265279-0zjpqnqp 92 15 unrecognized unrecognized JJ cord-265279-0zjpqnqp 92 16 asymptomatic asymptomatic JJ cord-265279-0zjpqnqp 92 17 or or CC cord-265279-0zjpqnqp 92 18 mild mild JJ cord-265279-0zjpqnqp 92 19 case case NN cord-265279-0zjpqnqp 92 20 RNA RNA NNP cord-265279-0zjpqnqp 92 21 and and CC cord-265279-0zjpqnqp 92 22 neutralising neutralise VBG cord-265279-0zjpqnqp 92 23 antibodies antibody NNS cord-265279-0zjpqnqp 92 24 in in IN cord-265279-0zjpqnqp 92 25 milk milk NN cord-265279-0zjpqnqp 92 26 collected collect VBN cord-265279-0zjpqnqp 92 27 according accord VBG cord-265279-0zjpqnqp 92 28 to to IN cord-265279-0zjpqnqp 92 29 local local JJ cord-265279-0zjpqnqp 92 30 customs custom NNS cord-265279-0zjpqnqp 92 31 from from IN cord-265279-0zjpqnqp 92 32 dromedary dromedary NN cord-265279-0zjpqnqp 92 33 camels camel NNS cord-265279-0zjpqnqp 92 34 Clinical clinical JJ cord-265279-0zjpqnqp 92 35 aspects aspect NNS cord-265279-0zjpqnqp 92 36 and and CC cord-265279-0zjpqnqp 92 37 outcomes outcome NNS cord-265279-0zjpqnqp 92 38 of of IN cord-265279-0zjpqnqp 92 39 70 70 CD cord-265279-0zjpqnqp 92 40 patients patient NNS cord-265279-0zjpqnqp 92 41 with with IN cord-265279-0zjpqnqp 92 42 Middle Middle NNP cord-265279-0zjpqnqp 92 43 East East NNP cord-265279-0zjpqnqp 92 44 respiratory respiratory JJ cord-265279-0zjpqnqp 92 45 syndrome syndrome NN cord-265279-0zjpqnqp 92 46 coronavirus coronavirus NN cord-265279-0zjpqnqp 92 47 infection infection NN cord-265279-0zjpqnqp 92 48 : : : cord-265279-0zjpqnqp 92 49 a a DT cord-265279-0zjpqnqp 92 50 single single JJ cord-265279-0zjpqnqp 92 51 - - HYPH cord-265279-0zjpqnqp 92 52 center center NN cord-265279-0zjpqnqp 92 53 experience experience NN cord-265279-0zjpqnqp 92 54 in in IN cord-265279-0zjpqnqp 92 55 Saudi Saudi NNP cord-265279-0zjpqnqp 92 56 Arabia Arabia NNP cord-265279-0zjpqnqp 93 1 One one CD cord-265279-0zjpqnqp 93 2 severe severe JJ cord-265279-0zjpqnqp 93 3 acute acute JJ cord-265279-0zjpqnqp 93 4 respiratory respiratory JJ cord-265279-0zjpqnqp 93 5 syndrome syndrome NN cord-265279-0zjpqnqp 93 6 coronavirus coronavirus NN cord-265279-0zjpqnqp 93 7 protein protein NN cord-265279-0zjpqnqp 93 8 complex complex NN cord-265279-0zjpqnqp 93 9 integrates integrate VBZ cord-265279-0zjpqnqp 93 10 processive processive JJ cord-265279-0zjpqnqp 93 11 RNA RNA NNP cord-265279-0zjpqnqp 93 12 polymerase polymerase NN cord-265279-0zjpqnqp 93 13 and and CC cord-265279-0zjpqnqp 93 14 exonuclease exonuclease NN cord-265279-0zjpqnqp 93 15 activities activity NNS cord-265279-0zjpqnqp 93 16 Middle Middle NNP cord-265279-0zjpqnqp 93 17 East East NNP cord-265279-0zjpqnqp 93 18 respiratory respiratory JJ cord-265279-0zjpqnqp 93 19 syndrome syndrome NN cord-265279-0zjpqnqp 93 20 coronavirus coronavirus NN cord-265279-0zjpqnqp 93 21 ( ( -LRB- cord-265279-0zjpqnqp 94 1 MERS MERS NNP cord-265279-0zjpqnqp 94 2 - - HYPH cord-265279-0zjpqnqp 94 3 CoV CoV NNP cord-265279-0zjpqnqp 94 4 ) ) -RRB- cord-265279-0zjpqnqp 94 5 c c NN cord-265279-0zjpqnqp 94 6 WHO who WP cord-265279-0zjpqnqp 94 7 Infection Infection NNP cord-265279-0zjpqnqp 94 8 control control NN cord-265279-0zjpqnqp 94 9 and and CC cord-265279-0zjpqnqp 94 10 MERS MERS NNP cord-265279-0zjpqnqp 94 11 - - HYPH cord-265279-0zjpqnqp 94 12 CoV CoV NNP cord-265279-0zjpqnqp 94 13 in in IN cord-265279-0zjpqnqp 94 14 health health NN cord-265279-0zjpqnqp 94 15 - - HYPH cord-265279-0zjpqnqp 94 16 care care NN cord-265279-0zjpqnqp 94 17 workers worker NNS