id	sid	tid	token	lemma	pos
cord-261566-fn08b0y2	1	1	key	key	JJ
cord-261566-fn08b0y2	1	2	:	:	:
cord-261566-fn08b0y2	1	3	cord-261566-fn08b0y2	cord-261566-fn08b0y2	JJ
cord-261566-fn08b0y2	1	4	authors	author	NNS
cord-261566-fn08b0y2	1	5	:	:	:
cord-261566-fn08b0y2	1	6	Mudgal	Mudgal	NNP
cord-261566-fn08b0y2	1	7	,	,	,
cord-261566-fn08b0y2	1	8	Rajat	Rajat	NNP
cord-261566-fn08b0y2	1	9	;	;	:
cord-261566-fn08b0y2	1	10	Nehul	Nehul	NNP
cord-261566-fn08b0y2	1	11	,	,	,
cord-261566-fn08b0y2	1	12	Sanketkumar	Sanketkumar	NNP
cord-261566-fn08b0y2	1	13	;	;	:
cord-261566-fn08b0y2	1	14	Tomar	Tomar	NNP
cord-261566-fn08b0y2	1	15	,	,	,
cord-261566-fn08b0y2	1	16	Shailly	Shailly	NNP
cord-261566-fn08b0y2	1	17	title	title	NN
cord-261566-fn08b0y2	1	18	:	:	:
cord-261566-fn08b0y2	1	19	Prospects	prospect	NNS
cord-261566-fn08b0y2	1	20	for	for	IN
cord-261566-fn08b0y2	1	21	mucosal	mucosal	JJ
cord-261566-fn08b0y2	1	22	vaccine	vaccine	NN
cord-261566-fn08b0y2	1	23	:	:	:
cord-261566-fn08b0y2	2	1	shutting	shut	VBG
cord-261566-fn08b0y2	2	2	the	the	DT
cord-261566-fn08b0y2	2	3	door	door	NN
cord-261566-fn08b0y2	2	4	on	on	IN
cord-261566-fn08b0y2	2	5	SARS	SARS	NNP
cord-261566-fn08b0y2	2	6	-	-	HYPH
cord-261566-fn08b0y2	2	7	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	2	8	date	date	NN
cord-261566-fn08b0y2	3	1	:	:	:
cord-261566-fn08b0y2	3	2	2020	2020	CD
cord-261566-fn08b0y2	3	3	-	-	HYPH
cord-261566-fn08b0y2	3	4	09	09	CD
cord-261566-fn08b0y2	3	5	-	-	SYM
cord-261566-fn08b0y2	3	6	15	15	CD
cord-261566-fn08b0y2	3	7	journal	journal	NN
cord-261566-fn08b0y2	3	8	:	:	:
cord-261566-fn08b0y2	4	1	Human	human	JJ
cord-261566-fn08b0y2	4	2	vaccines	vaccine	NNS
cord-261566-fn08b0y2	4	3	&	&	CC
cord-261566-fn08b0y2	4	4	immunotherapeutics	immunotherapeutics	NNP
cord-261566-fn08b0y2	4	5	DOI	DOI	NNP
cord-261566-fn08b0y2	4	6	:	:	:
cord-261566-fn08b0y2	4	7	10.1080/21645515.2020.1805992	10.1080/21645515.2020.1805992	NNP
cord-261566-fn08b0y2	4	8	sha	sha	NNP
cord-261566-fn08b0y2	4	9	:	:	:
cord-261566-fn08b0y2	4	10	59fef7cf90401a6462776644104644019e069f03	59fef7cf90401a6462776644104644019e069f03	NNP
cord-261566-fn08b0y2	4	11	doc_id	doc_id	CD
cord-261566-fn08b0y2	4	12	:	:	:
cord-261566-fn08b0y2	4	13	261566	261566	CD
cord-261566-fn08b0y2	4	14	cord_uid	cord_uid	NNS
cord-261566-fn08b0y2	4	15	:	:	:
cord-261566-fn08b0y2	5	1	fn08b0y2	fn08b0y2	NNP
cord-261566-fn08b0y2	6	1	The	the	DT
cord-261566-fn08b0y2	6	2	sudden	sudden	JJ
cord-261566-fn08b0y2	6	3	emergence	emergence	NN
cord-261566-fn08b0y2	6	4	of	of	IN
cord-261566-fn08b0y2	6	5	a	a	DT
cord-261566-fn08b0y2	6	6	highly	highly	RB
cord-261566-fn08b0y2	6	7	transmissible	transmissible	JJ
cord-261566-fn08b0y2	6	8	and	and	CC
cord-261566-fn08b0y2	6	9	pathogenic	pathogenic	JJ
cord-261566-fn08b0y2	6	10	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	6	11	SARS	SARS	NNP
cord-261566-fn08b0y2	6	12	-	-	HYPH
cord-261566-fn08b0y2	6	13	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	6	14	in	in	IN
cord-261566-fn08b0y2	6	15	December	December	NNP
cord-261566-fn08b0y2	6	16	2019	2019	CD
cord-261566-fn08b0y2	6	17	from	from	IN
cord-261566-fn08b0y2	6	18	China	China	NNP
cord-261566-fn08b0y2	6	19	and	and	CC
cord-261566-fn08b0y2	6	20	its	-PRON-	PRP$
cord-261566-fn08b0y2	6	21	rapid	rapid	JJ
cord-261566-fn08b0y2	6	22	global	global	JJ
cord-261566-fn08b0y2	6	23	spread	spread	NN
cord-261566-fn08b0y2	6	24	has	have	VBZ
cord-261566-fn08b0y2	6	25	posed	pose	VBN
cord-261566-fn08b0y2	6	26	an	an	DT
cord-261566-fn08b0y2	6	27	international	international	JJ
cord-261566-fn08b0y2	6	28	health	health	NN
cord-261566-fn08b0y2	6	29	emergency	emergency	NN
cord-261566-fn08b0y2	6	30	.	.	.
cord-261566-fn08b0y2	7	1	The	the	DT
cord-261566-fn08b0y2	7	2	rapid	rapid	JJ
cord-261566-fn08b0y2	7	3	development	development	NN
cord-261566-fn08b0y2	7	4	of	of	IN
cord-261566-fn08b0y2	7	5	an	an	DT
cord-261566-fn08b0y2	7	6	effective	effective	JJ
cord-261566-fn08b0y2	7	7	vaccine	vaccine	NN
cord-261566-fn08b0y2	7	8	is	be	VBZ
cord-261566-fn08b0y2	7	9	imperative	imperative	JJ
cord-261566-fn08b0y2	7	10	to	to	TO
cord-261566-fn08b0y2	7	11	control	control	VB
cord-261566-fn08b0y2	7	12	the	the	DT
cord-261566-fn08b0y2	7	13	spread	spread	NN
cord-261566-fn08b0y2	7	14	of	of	IN
cord-261566-fn08b0y2	7	15	SARS	SARS	NNP
cord-261566-fn08b0y2	7	16	-	-	HYPH
cord-261566-fn08b0y2	7	17	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	7	18	.	.	.
cord-261566-fn08b0y2	8	1	A	a	DT
cord-261566-fn08b0y2	8	2	number	number	NN
cord-261566-fn08b0y2	8	3	of	of	IN
cord-261566-fn08b0y2	8	4	concurrent	concurrent	JJ
cord-261566-fn08b0y2	8	5	efforts	effort	NNS
cord-261566-fn08b0y2	8	6	to	to	TO
cord-261566-fn08b0y2	8	7	find	find	VB
cord-261566-fn08b0y2	8	8	an	an	DT
cord-261566-fn08b0y2	8	9	effective	effective	JJ
cord-261566-fn08b0y2	8	10	therapeutic	therapeutic	JJ
cord-261566-fn08b0y2	8	11	agent	agent	NN
cord-261566-fn08b0y2	8	12	or	or	CC
cord-261566-fn08b0y2	8	13	vaccine	vaccine	NN
cord-261566-fn08b0y2	8	14	for	for	IN
cord-261566-fn08b0y2	8	15	COVID-19	COVID-19	NNP
cord-261566-fn08b0y2	8	16	(	(	-LRB-
cord-261566-fn08b0y2	8	17	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	8	18	disease	disease	NN
cord-261566-fn08b0y2	8	19	2019	2019	CD
cord-261566-fn08b0y2	8	20	)	)	-RRB-
cord-261566-fn08b0y2	8	21	are	be	VBP
cord-261566-fn08b0y2	8	22	being	be	VBG
cord-261566-fn08b0y2	8	23	undertaken	undertake	VBN
cord-261566-fn08b0y2	8	24	globally	globally	RB
cord-261566-fn08b0y2	8	25	.	.	.
cord-261566-fn08b0y2	9	1	Oral	oral	JJ
cord-261566-fn08b0y2	9	2	and	and	CC
cord-261566-fn08b0y2	9	3	nasal	nasal	JJ
cord-261566-fn08b0y2	9	4	mucosal	mucosal	JJ
cord-261566-fn08b0y2	9	5	surfaces	surface	NNS
cord-261566-fn08b0y2	9	6	serve	serve	VBP
cord-261566-fn08b0y2	9	7	as	as	IN
cord-261566-fn08b0y2	9	8	the	the	DT
cord-261566-fn08b0y2	9	9	primary	primary	JJ
cord-261566-fn08b0y2	9	10	portal	portal	NN
cord-261566-fn08b0y2	9	11	of	of	IN
cord-261566-fn08b0y2	9	12	entry	entry	NN
cord-261566-fn08b0y2	9	13	for	for	IN
cord-261566-fn08b0y2	9	14	pathogens	pathogen	NNS
cord-261566-fn08b0y2	9	15	like	like	IN
cord-261566-fn08b0y2	9	16	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	9	17	in	in	IN
cord-261566-fn08b0y2	9	18	the	the	DT
cord-261566-fn08b0y2	9	19	human	human	JJ
cord-261566-fn08b0y2	9	20	body	body	NN
cord-261566-fn08b0y2	9	21	.	.	.
cord-261566-fn08b0y2	10	1	As	as	IN
cord-261566-fn08b0y2	10	2	evidenced	evidence	VBN
cord-261566-fn08b0y2	10	3	by	by	IN
cord-261566-fn08b0y2	10	4	studies	study	NNS
cord-261566-fn08b0y2	10	5	on	on	IN
cord-261566-fn08b0y2	10	6	similar	similar	JJ
cord-261566-fn08b0y2	10	7	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	10	8	(	(	-LRB-
cord-261566-fn08b0y2	10	9	SARS	SARS	NNP
cord-261566-fn08b0y2	10	10	-	-	HYPH
cord-261566-fn08b0y2	10	11	CoV	CoV	NNP
cord-261566-fn08b0y2	10	12	and	and	CC
cord-261566-fn08b0y2	10	13	MERS	MERS	NNP
cord-261566-fn08b0y2	10	14	-	-	HYPH
cord-261566-fn08b0y2	10	15	CoV	CoV	NNP
cord-261566-fn08b0y2	10	16	)	)	-RRB-
cord-261566-fn08b0y2	10	17	,	,	,
cord-261566-fn08b0y2	10	18	mucosal	mucosal	JJ
cord-261566-fn08b0y2	10	19	vaccination	vaccination	NN
cord-261566-fn08b0y2	10	20	can	can	MD
cord-261566-fn08b0y2	10	21	provide	provide	VB
cord-261566-fn08b0y2	10	22	a	a	DT
cord-261566-fn08b0y2	10	23	safe	safe	JJ
cord-261566-fn08b0y2	10	24	and	and	CC
cord-261566-fn08b0y2	10	25	effective	effective	JJ
cord-261566-fn08b0y2	10	26	means	mean	NNS
cord-261566-fn08b0y2	10	27	for	for	IN
cord-261566-fn08b0y2	10	28	the	the	DT
cord-261566-fn08b0y2	10	29	induction	induction	NN
cord-261566-fn08b0y2	10	30	of	of	IN
cord-261566-fn08b0y2	10	31	long	long	RB
cord-261566-fn08b0y2	10	32	-	-	HYPH
cord-261566-fn08b0y2	10	33	lasting	last	VBG
cord-261566-fn08b0y2	10	34	systemic	systemic	JJ
cord-261566-fn08b0y2	10	35	and	and	CC
cord-261566-fn08b0y2	10	36	mucosal	mucosal	JJ
cord-261566-fn08b0y2	10	37	immunity	immunity	NN
cord-261566-fn08b0y2	10	38	to	to	TO
cord-261566-fn08b0y2	10	39	confer	confer	VB
cord-261566-fn08b0y2	10	40	protection	protection	NN
cord-261566-fn08b0y2	10	41	against	against	IN
cord-261566-fn08b0y2	10	42	SARS	SARS	NNP
cord-261566-fn08b0y2	10	43	-	-	HYPH
cord-261566-fn08b0y2	10	44	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	10	45	.	.	.
cord-261566-fn08b0y2	11	1	This	this	DT
cord-261566-fn08b0y2	11	2	article	article	NN
cord-261566-fn08b0y2	11	3	summarizes	summarize	VBZ
cord-261566-fn08b0y2	11	4	the	the	DT
cord-261566-fn08b0y2	11	5	approaches	approach	NNS
cord-261566-fn08b0y2	11	6	to	to	IN
cord-261566-fn08b0y2	11	7	an	an	DT
cord-261566-fn08b0y2	11	8	effective	effective	JJ
cord-261566-fn08b0y2	11	9	mucosal	mucosal	JJ
cord-261566-fn08b0y2	11	10	vaccine	vaccine	NN
cord-261566-fn08b0y2	11	11	formulation	formulation	NN
cord-261566-fn08b0y2	11	12	which	which	WDT
cord-261566-fn08b0y2	11	13	can	can	MD
cord-261566-fn08b0y2	11	14	be	be	VB
cord-261566-fn08b0y2	11	15	a	a	DT
cord-261566-fn08b0y2	11	16	rewarding	rewarding	JJ
cord-261566-fn08b0y2	11	17	approach	approach	NN
cord-261566-fn08b0y2	11	18	to	to	TO
cord-261566-fn08b0y2	11	19	combat	combat	VB
cord-261566-fn08b0y2	11	20	the	the	DT
cord-261566-fn08b0y2	11	21	unprecedented	unprecedented	JJ
cord-261566-fn08b0y2	11	22	threat	threat	NN
cord-261566-fn08b0y2	11	23	posed	pose	VBN
cord-261566-fn08b0y2	11	24	by	by	IN
cord-261566-fn08b0y2	11	25	this	this	DT
cord-261566-fn08b0y2	11	26	emerging	emerge	VBG
cord-261566-fn08b0y2	11	27	global	global	JJ
cord-261566-fn08b0y2	11	28	pandemic	pandemic	NN
cord-261566-fn08b0y2	11	29	.	.	.
cord-261566-fn08b0y2	12	1	In	in	IN
cord-261566-fn08b0y2	12	2	the	the	DT
cord-261566-fn08b0y2	12	3	21st	21st	JJ
cord-261566-fn08b0y2	12	4	century	century	NN
cord-261566-fn08b0y2	12	5	,	,	,
cord-261566-fn08b0y2	12	6	we	-PRON-	PRP
cord-261566-fn08b0y2	12	7	have	have	VBP
cord-261566-fn08b0y2	12	8	seen	see	VBN
cord-261566-fn08b0y2	12	9	a	a	DT
cord-261566-fn08b0y2	12	10	worldwide	worldwide	JJ
cord-261566-fn08b0y2	12	11	spread	spread	NN
cord-261566-fn08b0y2	12	12	of	of	IN
cord-261566-fn08b0y2	12	13	three	three	CD
cord-261566-fn08b0y2	12	14	previously	previously	RB
cord-261566-fn08b0y2	12	15	unknown	unknown	JJ
cord-261566-fn08b0y2	12	16	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	12	17	.	.	.
cord-261566-fn08b0y2	13	1	The	the	DT
cord-261566-fn08b0y2	13	2	first	first	JJ
cord-261566-fn08b0y2	13	3	outbreak	outbreak	NN
cord-261566-fn08b0y2	13	4	of	of	IN
cord-261566-fn08b0y2	13	5	Severe	severe	JJ
cord-261566-fn08b0y2	13	6	Acute	acute	JJ
cord-261566-fn08b0y2	13	7	Respiratory	Respiratory	NNP
cord-261566-fn08b0y2	13	8	Syndrome	Syndrome	NNP
cord-261566-fn08b0y2	13	9	(	(	-LRB-
cord-261566-fn08b0y2	13	10	SARS	SARS	NNP
cord-261566-fn08b0y2	13	11	)	)	-RRB-
cord-261566-fn08b0y2	13	12	occurred	occur	VBD
cord-261566-fn08b0y2	13	13	in	in	IN
cord-261566-fn08b0y2	13	14	November	November	NNP
cord-261566-fn08b0y2	13	15	2002	2002	CD
cord-261566-fn08b0y2	13	16	in	in	IN
cord-261566-fn08b0y2	13	17	the	the	DT
cord-261566-fn08b0y2	13	18	Guangdong	Guangdong	NNP
cord-261566-fn08b0y2	13	19	province	province	NN
cord-261566-fn08b0y2	13	20	,	,	,
cord-261566-fn08b0y2	13	21	China	China	NNP
cord-261566-fn08b0y2	13	22	.	.	.
cord-261566-fn08b0y2	14	1	The	the	DT
cord-261566-fn08b0y2	14	2	causative	causative	JJ
cord-261566-fn08b0y2	14	3	agent	agent	NN
cord-261566-fn08b0y2	14	4	of	of	IN
cord-261566-fn08b0y2	14	5	the	the	DT
cord-261566-fn08b0y2	14	6	2002	2002	CD
cord-261566-fn08b0y2	14	7	SARS	SARS	NNP
cord-261566-fn08b0y2	14	8	outbreak	outbreak	NN
cord-261566-fn08b0y2	14	9	was	be	VBD
cord-261566-fn08b0y2	14	10	identified	identify	VBN
cord-261566-fn08b0y2	14	11	as	as	IN
cord-261566-fn08b0y2	14	12	SARS	SARS	NNP
cord-261566-fn08b0y2	14	13	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	14	14	(	(	-LRB-
cord-261566-fn08b0y2	14	15	SARS	SARS	NNP
cord-261566-fn08b0y2	14	16	-	-	HYPH
cord-261566-fn08b0y2	14	17	CoV	CoV	NNP
cord-261566-fn08b0y2	14	18	)	)	-RRB-
cord-261566-fn08b0y2	14	19	.	.	.
cord-261566-fn08b0y2	15	1	1	1	LS
cord-261566-fn08b0y2	16	1	Another	another	DT
cord-261566-fn08b0y2	16	2	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	16	3	,	,	,
cord-261566-fn08b0y2	16	4	Middle	Middle	NNP
cord-261566-fn08b0y2	16	5	East	East	NNP
cord-261566-fn08b0y2	16	6	respiratory	respiratory	JJ
cord-261566-fn08b0y2	16	7	syndrome	syndrome	NN
cord-261566-fn08b0y2	16	8	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	16	9	(	(	-LRB-
cord-261566-fn08b0y2	16	10	MERS	MERS	NNP
cord-261566-fn08b0y2	16	11	-	-	HYPH
cord-261566-fn08b0y2	16	12	CoV	CoV	NNP
cord-261566-fn08b0y2	16	13	)	)	-RRB-
cord-261566-fn08b0y2	16	14	was	be	VBD
cord-261566-fn08b0y2	16	15	first	first	RB
cord-261566-fn08b0y2	16	16	identified	identify	VBN
cord-261566-fn08b0y2	16	17	in	in	IN
cord-261566-fn08b0y2	16	18	Saudi	Saudi	NNP
cord-261566-fn08b0y2	16	19	Arabia	Arabia	NNP
cord-261566-fn08b0y2	16	20	in	in	IN
cord-261566-fn08b0y2	16	21	2012	2012	CD
cord-261566-fn08b0y2	16	22	.	.	.
cord-261566-fn08b0y2	17	1	2	2	LS
cord-261566-fn08b0y2	18	1	On	on	IN
cord-261566-fn08b0y2	18	2	December	December	NNP
cord-261566-fn08b0y2	18	3	31	31	CD
cord-261566-fn08b0y2	18	4	,	,	,
cord-261566-fn08b0y2	18	5	2019	2019	CD
cord-261566-fn08b0y2	18	6	,	,	,
cord-261566-fn08b0y2	18	7	several	several	JJ
cord-261566-fn08b0y2	18	8	cases	case	NNS
cord-261566-fn08b0y2	18	9	of	of	IN
cord-261566-fn08b0y2	18	10	pneumonia	pneumonia	NN
cord-261566-fn08b0y2	18	11	were	be	VBD
cord-261566-fn08b0y2	18	12	reported	report	VBN
cord-261566-fn08b0y2	18	13	in	in	IN
cord-261566-fn08b0y2	18	14	Wuhan	Wuhan	NNP
cord-261566-fn08b0y2	18	15	,	,	,
cord-261566-fn08b0y2	18	16	China	China	NNP
cord-261566-fn08b0y2	18	17	.	.	.
cord-261566-fn08b0y2	19	1	3	3	LS
cord-261566-fn08b0y2	20	1	The	the	DT
cord-261566-fn08b0y2	20	2	etiological	etiological	JJ
cord-261566-fn08b0y2	20	3	agent	agent	NN
cord-261566-fn08b0y2	20	4	of	of	IN
cord-261566-fn08b0y2	20	5	the	the	DT
cord-261566-fn08b0y2	20	6	2019	2019	CD
cord-261566-fn08b0y2	20	7	outbreak	outbreak	NN
cord-261566-fn08b0y2	20	8	was	be	VBD
cord-261566-fn08b0y2	20	9	later	later	RB
cord-261566-fn08b0y2	20	10	identified	identify	VBN
cord-261566-fn08b0y2	20	11	as	as	IN
cord-261566-fn08b0y2	20	12	SARS	SARS	NNP
cord-261566-fn08b0y2	20	13	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	20	14	2	2	CD
cord-261566-fn08b0y2	20	15	(	(	-LRB-
cord-261566-fn08b0y2	20	16	SARS	SARS	NNP
cord-261566-fn08b0y2	20	17	-	-	HYPH
cord-261566-fn08b0y2	20	18	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	20	19	)	)	-RRB-
cord-261566-fn08b0y2	20	20	because	because	IN
cord-261566-fn08b0y2	20	21	the	the	DT
cord-261566-fn08b0y2	20	22	genomic	genomic	JJ
cord-261566-fn08b0y2	20	23	sequence	sequence	NN
cord-261566-fn08b0y2	20	24	was	be	VBD
cord-261566-fn08b0y2	20	25	closely	closely	RB
cord-261566-fn08b0y2	20	26	related	relate	VBN
cord-261566-fn08b0y2	20	27	to	to	IN
cord-261566-fn08b0y2	20	28	that	that	DT
cord-261566-fn08b0y2	20	29	of	of	IN
cord-261566-fn08b0y2	20	30	the	the	DT
cord-261566-fn08b0y2	20	31	SARS	SARS	NNP
cord-261566-fn08b0y2	20	32	-	-	HYPH
cord-261566-fn08b0y2	20	33	CoV	CoV	NNP
cord-261566-fn08b0y2	20	34	from	from	IN
cord-261566-fn08b0y2	20	35	2003	2003	CD
cord-261566-fn08b0y2	20	36	.	.	.
cord-261566-fn08b0y2	21	1	4	4	LS
cord-261566-fn08b0y2	21	2	,	,	,
cord-261566-fn08b0y2	21	3	5	5	CD
cord-261566-fn08b0y2	22	1	On	on	IN
cord-261566-fn08b0y2	22	2	February	February	NNP
cord-261566-fn08b0y2	22	3	12	12	CD
cord-261566-fn08b0y2	22	4	,	,	,
cord-261566-fn08b0y2	22	5	2020	2020	CD
cord-261566-fn08b0y2	22	6	,	,	,
cord-261566-fn08b0y2	22	7	the	the	DT
cord-261566-fn08b0y2	22	8	world	world	NNP
cord-261566-fn08b0y2	22	9	health	health	NNP
cord-261566-fn08b0y2	22	10	organization	organization	NNP
cord-261566-fn08b0y2	22	11	(	(	-LRB-
cord-261566-fn08b0y2	22	12	WHO	who	WP
cord-261566-fn08b0y2	22	13	)	)	-RRB-
cord-261566-fn08b0y2	22	14	named	name	VBD
cord-261566-fn08b0y2	22	15	the	the	DT
cord-261566-fn08b0y2	22	16	disease	disease	NN
cord-261566-fn08b0y2	22	17	caused	cause	VBN
cord-261566-fn08b0y2	22	18	by	by	IN
cord-261566-fn08b0y2	22	19	the	the	DT
cord-261566-fn08b0y2	22	20	novel	novel	JJ
cord-261566-fn08b0y2	22	21	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	22	22	(	(	-LRB-
cord-261566-fn08b0y2	22	23	SARS	SARS	NNP
cord-261566-fn08b0y2	22	24	-	-	HYPH
cord-261566-fn08b0y2	22	25	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	22	26	)	)	-RRB-
cord-261566-fn08b0y2	22	27	as	as	IN
cord-261566-fn08b0y2	22	28	Coronavirus	Coronavirus	NNP
cord-261566-fn08b0y2	22	29	Disease	Disease	NNP
cord-261566-fn08b0y2	22	30	2019	2019	CD
cord-261566-fn08b0y2	22	31	.	.	.
cord-261566-fn08b0y2	23	1	Coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	23	2	belong	belong	VBP
cord-261566-fn08b0y2	23	3	to	to	IN
cord-261566-fn08b0y2	23	4	the	the	DT
cord-261566-fn08b0y2	23	5	Coronaviridae	Coronaviridae	NNP
cord-261566-fn08b0y2	23	6	family	family	NN
cord-261566-fn08b0y2	23	7	.	.	.
cord-261566-fn08b0y2	24	1	The	the	DT
cord-261566-fn08b0y2	24	2	family	family	NN
cord-261566-fn08b0y2	24	3	members	member	NNS
cord-261566-fn08b0y2	24	4	are	be	VBP
cord-261566-fn08b0y2	24	5	enveloped	envelop	VBN
cord-261566-fn08b0y2	24	6	,	,	,
cord-261566-fn08b0y2	24	7	positive	positive	JJ
cord-261566-fn08b0y2	24	8	-	-	HYPH
cord-261566-fn08b0y2	24	9	stranded	strand	VBN
cord-261566-fn08b0y2	24	10	RNA	RNA	NNP
cord-261566-fn08b0y2	24	11	viruses	virus	NNS
cord-261566-fn08b0y2	24	12	which	which	WDT
cord-261566-fn08b0y2	24	13	appear	appear	VBP
cord-261566-fn08b0y2	24	14	as	as	IN
cord-261566-fn08b0y2	24	15	crown	crown	NN
cord-261566-fn08b0y2	24	16	-	-	HYPH
cord-261566-fn08b0y2	24	17	like	like	JJ
cord-261566-fn08b0y2	24	18	entities	entity	NNS
cord-261566-fn08b0y2	24	19	under	under	IN
cord-261566-fn08b0y2	24	20	the	the	DT
cord-261566-fn08b0y2	24	21	electron	electron	NN
cord-261566-fn08b0y2	24	22	microscope	microscope	NN
cord-261566-fn08b0y2	24	23	due	due	JJ
cord-261566-fn08b0y2	24	24	to	to	IN
cord-261566-fn08b0y2	24	25	spikes	spike	NNS
cord-261566-fn08b0y2	24	26	of	of	IN
cord-261566-fn08b0y2	24	27	glycoproteins	glycoprotein	NNS
cord-261566-fn08b0y2	24	28	protruding	protrude	VBG
cord-261566-fn08b0y2	24	29	from	from	IN
cord-261566-fn08b0y2	24	30	their	-PRON-	PRP$
cord-261566-fn08b0y2	24	31	viral	viral	JJ
cord-261566-fn08b0y2	24	32	envelopes	envelope	NNS
cord-261566-fn08b0y2	24	33	,	,	,
cord-261566-fn08b0y2	24	34	thus	thus	RB
cord-261566-fn08b0y2	24	35	exhibiting	exhibit	VBG
cord-261566-fn08b0y2	24	36	a	a	DT
cord-261566-fn08b0y2	24	37	corona	corona	NN
cord-261566-fn08b0y2	24	38	-	-	HYPH
cord-261566-fn08b0y2	24	39	like	like	JJ
cord-261566-fn08b0y2	24	40	appearance	appearance	NN
cord-261566-fn08b0y2	24	41	.	.	.
cord-261566-fn08b0y2	25	1	6	6	CD
cord-261566-fn08b0y2	26	1	The	the	DT
cord-261566-fn08b0y2	26	2	Coronaviridae	Coronaviridae	NNP
cord-261566-fn08b0y2	26	3	family	family	NN
cord-261566-fn08b0y2	26	4	is	be	VBZ
cord-261566-fn08b0y2	26	5	divided	divide	VBN
cord-261566-fn08b0y2	26	6	into	into	IN
cord-261566-fn08b0y2	26	7	two	two	CD
cord-261566-fn08b0y2	26	8	subfamilies	subfamily	NNS
cord-261566-fn08b0y2	26	9	:	:	:
cord-261566-fn08b0y2	26	10	Letovirinae	Letovirinae	NNP
cord-261566-fn08b0y2	26	11	and	and	CC
cord-261566-fn08b0y2	26	12	Orthocoronavirinae	Orthocoronavirinae	NNP
cord-261566-fn08b0y2	26	13	.	.	.
cord-261566-fn08b0y2	27	1	The	the	DT
cord-261566-fn08b0y2	27	2	latter	latter	JJ
cord-261566-fn08b0y2	27	3	consists	consist	VBZ
cord-261566-fn08b0y2	27	4	of	of	IN
cord-261566-fn08b0y2	27	5	the	the	DT
cord-261566-fn08b0y2	27	6	genera	genera	NNP
cord-261566-fn08b0y2	27	7	Alphacoronvirus	Alphacoronvirus	NNP
cord-261566-fn08b0y2	27	8	,	,	,
cord-261566-fn08b0y2	27	9	Betacoronavirus	Betacoronavirus	NNP
cord-261566-fn08b0y2	27	10	,	,	,
cord-261566-fn08b0y2	27	11	Gammacoronavirus	Gammacoronavirus	NNP
cord-261566-fn08b0y2	27	12	,	,	,
cord-261566-fn08b0y2	27	13	and	and	CC
cord-261566-fn08b0y2	27	14	Deltacoronavirus	Deltacoronavirus	NNP
cord-261566-fn08b0y2	27	15	.	.	.
cord-261566-fn08b0y2	28	1	The	the	DT
cord-261566-fn08b0y2	28	2	pathogenic	pathogenic	JJ
cord-261566-fn08b0y2	28	3	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	28	4	:	:	:
cord-261566-fn08b0y2	29	1	SARS	SARS	NNP
cord-261566-fn08b0y2	29	2	-	-	HYPH
cord-261566-fn08b0y2	29	3	CoV	CoV	NNP
cord-261566-fn08b0y2	29	4	,	,	,
cord-261566-fn08b0y2	29	5	MERS	MERS	NNP
cord-261566-fn08b0y2	29	6	-	-	HYPH
cord-261566-fn08b0y2	29	7	CoV	CoV	NNP
cord-261566-fn08b0y2	29	8	,	,	,
cord-261566-fn08b0y2	29	9	and	and	CC
cord-261566-fn08b0y2	29	10	SARS	SARS	NNP
cord-261566-fn08b0y2	29	11	-	-	HYPH
cord-261566-fn08b0y2	29	12	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	29	13	are	be	VBP
cord-261566-fn08b0y2	29	14	all	all	DT
cord-261566-fn08b0y2	29	15	betacoronaviruses	betacoronaviruse	NNS
cord-261566-fn08b0y2	29	16	.	.	.
cord-261566-fn08b0y2	30	1	6	6	CD
cord-261566-fn08b0y2	31	1	Among	among	IN
cord-261566-fn08b0y2	31	2	known	know	VBN
cord-261566-fn08b0y2	31	3	RNA	RNA	NNP
cord-261566-fn08b0y2	31	4	viruses	virus	NNS
cord-261566-fn08b0y2	31	5	,	,	,
cord-261566-fn08b0y2	31	6	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	31	7	have	have	VBP
cord-261566-fn08b0y2	31	8	the	the	DT
cord-261566-fn08b0y2	31	9	largest	large	JJS
cord-261566-fn08b0y2	31	10	genomes	genome	NNS
cord-261566-fn08b0y2	31	11	size	size	NN
cord-261566-fn08b0y2	31	12	in	in	IN
cord-261566-fn08b0y2	31	13	the	the	DT
cord-261566-fn08b0y2	31	14	range	range	NN
cord-261566-fn08b0y2	31	15	of	of	IN
cord-261566-fn08b0y2	31	16	26	26	CD
cord-261566-fn08b0y2	31	17	to	to	TO
cord-261566-fn08b0y2	31	18	32	32	CD
cord-261566-fn08b0y2	31	19	kb	kb	NNS
cord-261566-fn08b0y2	31	20	in	in	IN
cord-261566-fn08b0y2	31	21	length	length	NN
cord-261566-fn08b0y2	31	22	.	.	.
cord-261566-fn08b0y2	32	1	7	7	CD
cord-261566-fn08b0y2	32	2	Two	two	CD
cord-261566-fn08b0y2	32	3	-	-	HYPH
cord-261566-fn08b0y2	32	4	third	third	NN
cord-261566-fn08b0y2	32	5	of	of	IN
cord-261566-fn08b0y2	32	6	the	the	DT
cord-261566-fn08b0y2	32	7	viral	viral	JJ
cord-261566-fn08b0y2	32	8	genome	genome	NN
cord-261566-fn08b0y2	32	9	at	at	IN
cord-261566-fn08b0y2	32	10	5ˊ	5ˊ	CD
cord-261566-fn08b0y2	32	11	end	end	NN
cord-261566-fn08b0y2	32	12	encodes	encode	VBZ
cord-261566-fn08b0y2	32	13	up	up	IN
cord-261566-fn08b0y2	32	14	to	to	TO
cord-261566-fn08b0y2	32	15	16	16	CD
cord-261566-fn08b0y2	32	16	nonstructural	nonstructural	JJ
cord-261566-fn08b0y2	32	17	replicase	replicase	NN
cord-261566-fn08b0y2	32	18	proteins	protein	NNS
cord-261566-fn08b0y2	32	19	which	which	WDT
cord-261566-fn08b0y2	32	20	are	be	VBP
cord-261566-fn08b0y2	32	21	translated	translate	VBN
cord-261566-fn08b0y2	32	22	as	as	IN
cord-261566-fn08b0y2	32	23	two	two	CD
cord-261566-fn08b0y2	32	24	polyproteins	polyprotein	NNS
cord-261566-fn08b0y2	32	25	:	:	:
cord-261566-fn08b0y2	33	1	pp1a	pp1a	NNP
cord-261566-fn08b0y2	33	2	and	and	CC
cord-261566-fn08b0y2	33	3	pp1ab	pp1ab	NNP
cord-261566-fn08b0y2	33	4	.	.	.
cord-261566-fn08b0y2	34	1	The	the	DT
cord-261566-fn08b0y2	34	2	genes	gene	NNS
cord-261566-fn08b0y2	34	3	encoding	encode	VBG
cord-261566-fn08b0y2	34	4	structural	structural	JJ
cord-261566-fn08b0y2	34	5	proteins	protein	NNS
cord-261566-fn08b0y2	34	6	,	,	,
cord-261566-fn08b0y2	34	7	including	include	VBG
cord-261566-fn08b0y2	34	8	spike	spike	NN
cord-261566-fn08b0y2	34	9	(	(	-LRB-
cord-261566-fn08b0y2	34	10	S	S	NNP
cord-261566-fn08b0y2	34	11	)	)	-RRB-
cord-261566-fn08b0y2	34	12	,	,	,
cord-261566-fn08b0y2	34	13	envelope	envelope	NN
cord-261566-fn08b0y2	34	14	(	(	-LRB-
cord-261566-fn08b0y2	34	15	E	E	NNP
cord-261566-fn08b0y2	34	16	)	)	-RRB-
cord-261566-fn08b0y2	34	17	,	,	,
cord-261566-fn08b0y2	34	18	membrane	membrane	NN
cord-261566-fn08b0y2	34	19	(	(	-LRB-
cord-261566-fn08b0y2	34	20	M	M	NNP
cord-261566-fn08b0y2	34	21	)	)	-RRB-
cord-261566-fn08b0y2	34	22	,	,	,
cord-261566-fn08b0y2	34	23	and	and	CC
cord-261566-fn08b0y2	34	24	nucleocapsid	nucleocapsid	NN
cord-261566-fn08b0y2	34	25	(	(	-LRB-
cord-261566-fn08b0y2	34	26	N	N	NNP
cord-261566-fn08b0y2	34	27	)	)	-RRB-
cord-261566-fn08b0y2	34	28	proteins	protein	NNS
cord-261566-fn08b0y2	34	29	are	be	VBP
cord-261566-fn08b0y2	34	30	present	present	JJ
cord-261566-fn08b0y2	34	31	at	at	IN
cord-261566-fn08b0y2	34	32	3ˊ	3ˊ	CD
cord-261566-fn08b0y2	34	33	end	end	NN
cord-261566-fn08b0y2	34	34	of	of	IN
cord-261566-fn08b0y2	34	35	genomic	genomic	JJ
cord-261566-fn08b0y2	34	36	RNA	rna	NN
cord-261566-fn08b0y2	34	37	.	.	.
cord-261566-fn08b0y2	35	1	7	7	CD
cord-261566-fn08b0y2	35	2	,	,	,
cord-261566-fn08b0y2	35	3	8	8	CD
cord-261566-fn08b0y2	35	4	The	the	DT
cord-261566-fn08b0y2	35	5	S	S	NNP
cord-261566-fn08b0y2	35	6	protein	protein	NN
cord-261566-fn08b0y2	35	7	of	of	IN
cord-261566-fn08b0y2	35	8	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	35	9	is	be	VBZ
cord-261566-fn08b0y2	35	10	one	one	CD
cord-261566-fn08b0y2	35	11	of	of	IN
cord-261566-fn08b0y2	35	12	the	the	DT
cord-261566-fn08b0y2	35	13	most	most	RBS
cord-261566-fn08b0y2	35	14	important	important	JJ
cord-261566-fn08b0y2	35	15	targets	target	NNS
cord-261566-fn08b0y2	35	16	for	for	IN
cord-261566-fn08b0y2	35	17	the	the	DT
cord-261566-fn08b0y2	35	18	development	development	NN
cord-261566-fn08b0y2	35	19	of	of	IN
cord-261566-fn08b0y2	35	20	SARS	SARS	NNP
cord-261566-fn08b0y2	35	21	vaccines	vaccine	NNS
cord-261566-fn08b0y2	35	22	and	and	CC
cord-261566-fn08b0y2	35	23	therapeutics	therapeutic	NNS
cord-261566-fn08b0y2	35	24	because	because	IN
cord-261566-fn08b0y2	35	25	it	-PRON-	PRP
cord-261566-fn08b0y2	35	26	is	be	VBZ
cord-261566-fn08b0y2	35	27	involved	involve	VBN
cord-261566-fn08b0y2	35	28	in	in	IN
cord-261566-fn08b0y2	35	29	receptor	receptor	NN
cord-261566-fn08b0y2	35	30	recognition	recognition	NN
cord-261566-fn08b0y2	35	31	,	,	,
cord-261566-fn08b0y2	35	32	as	as	RB
cord-261566-fn08b0y2	35	33	well	well	RB
cord-261566-fn08b0y2	35	34	as	as	IN
cord-261566-fn08b0y2	35	35	virus	virus	NN
cord-261566-fn08b0y2	35	36	attachment	attachment	NN
cord-261566-fn08b0y2	35	37	and	and	CC
cord-261566-fn08b0y2	35	38	entry	entry	NN
cord-261566-fn08b0y2	35	39	.	.	.
cord-261566-fn08b0y2	36	1	The	the	DT
cord-261566-fn08b0y2	36	2	S	S	NNP
cord-261566-fn08b0y2	36	3	protein	protein	NN
cord-261566-fn08b0y2	36	4	is	be	VBZ
cord-261566-fn08b0y2	36	5	made	make	VBN
cord-261566-fn08b0y2	36	6	up	up	RP
cord-261566-fn08b0y2	36	7	of	of	IN
cord-261566-fn08b0y2	36	8	S1	S1	NNP
cord-261566-fn08b0y2	36	9	and	and	CC
cord-261566-fn08b0y2	36	10	S2	S2	NNP
cord-261566-fn08b0y2	36	11	subunits	subunit	NNS
cord-261566-fn08b0y2	36	12	.	.	.
cord-261566-fn08b0y2	37	1	S1	s1	NN
cord-261566-fn08b0y2	37	2	subunit	subunit	NN
cord-261566-fn08b0y2	37	3	has	have	VBZ
cord-261566-fn08b0y2	37	4	the	the	DT
cord-261566-fn08b0y2	37	5	receptor	receptor	NN
cord-261566-fn08b0y2	37	6	-	-	HYPH
cord-261566-fn08b0y2	37	7	binding	bind	VBG
cord-261566-fn08b0y2	37	8	domain	domain	NN
cord-261566-fn08b0y2	37	9	(	(	-LRB-
cord-261566-fn08b0y2	37	10	RBD	RBD	NNP
cord-261566-fn08b0y2	37	11	)	)	-RRB-
cord-261566-fn08b0y2	37	12	which	which	WDT
cord-261566-fn08b0y2	37	13	binds	bind	VBZ
cord-261566-fn08b0y2	37	14	with	with	IN
cord-261566-fn08b0y2	37	15	host	host	NN
cord-261566-fn08b0y2	37	16	receptor	receptor	NN
cord-261566-fn08b0y2	38	1	and	and	CC
cord-261566-fn08b0y2	38	2	then	then	RB
cord-261566-fn08b0y2	38	3	the	the	DT
cord-261566-fn08b0y2	38	4	S2	S2	NNP
cord-261566-fn08b0y2	38	5	subunit	subunit	NN
cord-261566-fn08b0y2	38	6	mediates	mediate	VBZ
cord-261566-fn08b0y2	38	7	the	the	DT
cord-261566-fn08b0y2	38	8	fusion	fusion	NN
cord-261566-fn08b0y2	38	9	of	of	IN
cord-261566-fn08b0y2	38	10	viral	viral	JJ
cord-261566-fn08b0y2	38	11	and	and	CC
cord-261566-fn08b0y2	38	12	host	host	NN
cord-261566-fn08b0y2	38	13	membranes	membrane	NNS
cord-261566-fn08b0y2	38	14	.	.	.
cord-261566-fn08b0y2	39	1	9	9	CD
cord-261566-fn08b0y2	39	2	Host	host	NN
cord-261566-fn08b0y2	39	3	receptor	receptor	NN
cord-261566-fn08b0y2	39	4	for	for	IN
cord-261566-fn08b0y2	39	5	SARS	SARS	NNP
cord-261566-fn08b0y2	39	6	-	-	HYPH
cord-261566-fn08b0y2	39	7	CoV	CoV	NNP
cord-261566-fn08b0y2	39	8	is	be	VBZ
cord-261566-fn08b0y2	39	9	angiotensinconverting	angiotensinconverte	VBG
cord-261566-fn08b0y2	39	10	enzyme	enzyme	NN
cord-261566-fn08b0y2	39	11	2	2	CD
cord-261566-fn08b0y2	39	12	(	(	-LRB-
cord-261566-fn08b0y2	39	13	ACE2	ACE2	NNP
cord-261566-fn08b0y2	39	14	)	)	-RRB-
cord-261566-fn08b0y2	39	15	,	,	,
cord-261566-fn08b0y2	39	16	whereas	whereas	IN
cord-261566-fn08b0y2	39	17	MERS	MERS	NNP
cord-261566-fn08b0y2	39	18	-	-	HYPH
cord-261566-fn08b0y2	39	19	CoV	CoV	NNP
cord-261566-fn08b0y2	39	20	recognizes	recognize	VBZ
cord-261566-fn08b0y2	39	21	dipeptidyl	dipeptidyl	JJ
cord-261566-fn08b0y2	39	22	peptidase	peptidase	NN
cord-261566-fn08b0y2	39	23	4	4	CD
cord-261566-fn08b0y2	39	24	(	(	-LRB-
cord-261566-fn08b0y2	39	25	DPP4	DPP4	NNP
cord-261566-fn08b0y2	39	26	)	)	-RRB-
cord-261566-fn08b0y2	39	27	as	as	IN
cord-261566-fn08b0y2	39	28	its	-PRON-	PRP$
cord-261566-fn08b0y2	39	29	receptor	receptor	NN
cord-261566-fn08b0y2	39	30	.	.	.
cord-261566-fn08b0y2	40	1	10	10	CD
cord-261566-fn08b0y2	40	2	,	,	,
cord-261566-fn08b0y2	40	3	11	11	CD
cord-261566-fn08b0y2	41	1	The	the	DT
cord-261566-fn08b0y2	41	2	common	common	JJ
cord-261566-fn08b0y2	41	3	symptoms	symptom	NNS
cord-261566-fn08b0y2	41	4	of	of	IN
cord-261566-fn08b0y2	41	5	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	41	6	infection	infection	NN
cord-261566-fn08b0y2	41	7	are	be	VBP
cord-261566-fn08b0y2	41	8	fever	fever	NN
cord-261566-fn08b0y2	41	9	,	,	,
cord-261566-fn08b0y2	41	10	cough	cough	NN
cord-261566-fn08b0y2	41	11	,	,	,
cord-261566-fn08b0y2	41	12	and	and	CC
cord-261566-fn08b0y2	41	13	sore	sore	JJ
cord-261566-fn08b0y2	41	14	throat	throat	NN
cord-261566-fn08b0y2	41	15	.	.	.
cord-261566-fn08b0y2	42	1	Clinically	clinically	RB
cord-261566-fn08b0y2	42	2	,	,	,
cord-261566-fn08b0y2	42	3	patients	patient	NNS
cord-261566-fn08b0y2	42	4	with	with	IN
cord-261566-fn08b0y2	42	5	SARS	SARS	NNP
cord-261566-fn08b0y2	42	6	suffer	suffer	VBP
cord-261566-fn08b0y2	42	7	from	from	IN
cord-261566-fn08b0y2	42	8	atypical	atypical	JJ
cord-261566-fn08b0y2	42	9	pneumonia	pneumonia	NN
cord-261566-fn08b0y2	42	10	.	.	.
cord-261566-fn08b0y2	43	1	12	12	CD
cord-261566-fn08b0y2	43	2	,	,	,
cord-261566-fn08b0y2	43	3	13	13	CD
cord-261566-fn08b0y2	43	4	Clinical	clinical	JJ
cord-261566-fn08b0y2	43	5	presentation	presentation	NN
cord-261566-fn08b0y2	43	6	of	of	IN
cord-261566-fn08b0y2	43	7	SARS	SARS	NNP
cord-261566-fn08b0y2	43	8	-	-	HYPH
cord-261566-fn08b0y2	43	9	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	43	10	patients	patient	NNS
cord-261566-fn08b0y2	43	11	is	be	VBZ
cord-261566-fn08b0y2	43	12	similar	similar	JJ
cord-261566-fn08b0y2	43	13	to	to	IN
cord-261566-fn08b0y2	43	14	patients	patient	NNS
cord-261566-fn08b0y2	43	15	infected	infect	VBN
cord-261566-fn08b0y2	43	16	with	with	IN
cord-261566-fn08b0y2	43	17	SARS	SARS	NNP
cord-261566-fn08b0y2	43	18	-	-	HYPH
cord-261566-fn08b0y2	43	19	CoV.	CoV.	NNP
cord-261566-fn08b0y2	44	1	COVID-19	COVID-19	NNP
cord-261566-fn08b0y2	44	2	manifests	manifest	VBZ
cord-261566-fn08b0y2	44	3	itself	-PRON-	PRP
cord-261566-fn08b0y2	44	4	with	with	IN
cord-261566-fn08b0y2	44	5	symptoms	symptom	NNS
cord-261566-fn08b0y2	44	6	including	include	VBG
cord-261566-fn08b0y2	44	7	fever	fever	NN
cord-261566-fn08b0y2	44	8	,	,	,
cord-261566-fn08b0y2	44	9	dry	dry	JJ
cord-261566-fn08b0y2	44	10	cough	cough	NN
cord-261566-fn08b0y2	44	11	,	,	,
cord-261566-fn08b0y2	44	12	fatigue	fatigue	NN
cord-261566-fn08b0y2	44	13	,	,	,
cord-261566-fn08b0y2	44	14	and	and	CC
cord-261566-fn08b0y2	44	15	acute	acute	JJ
cord-261566-fn08b0y2	44	16	respiratory	respiratory	JJ
cord-261566-fn08b0y2	44	17	distress	distress	NN
cord-261566-fn08b0y2	44	18	syndrome	syndrome	NN
cord-261566-fn08b0y2	44	19	.	.	.
cord-261566-fn08b0y2	45	1	3	3	CD
cord-261566-fn08b0y2	45	2	,	,	,
cord-261566-fn08b0y2	45	3	14	14	CD
cord-261566-fn08b0y2	45	4	These	these	DT
cord-261566-fn08b0y2	45	5	clinical	clinical	JJ
cord-261566-fn08b0y2	45	6	features	feature	NNS
cord-261566-fn08b0y2	45	7	are	be	VBP
cord-261566-fn08b0y2	45	8	a	a	DT
cord-261566-fn08b0y2	45	9	direct	direct	JJ
cord-261566-fn08b0y2	45	10	consequence	consequence	NN
cord-261566-fn08b0y2	45	11	of	of	IN
cord-261566-fn08b0y2	45	12	massive	massive	JJ
cord-261566-fn08b0y2	45	13	alveolar	alveolar	JJ
cord-261566-fn08b0y2	45	14	epithelial	epithelial	JJ
cord-261566-fn08b0y2	45	15	cell	cell	NN
cord-261566-fn08b0y2	45	16	and	and	CC
cord-261566-fn08b0y2	45	17	vascular	vascular	JJ
cord-261566-fn08b0y2	45	18	endothelial	endothelial	JJ
cord-261566-fn08b0y2	45	19	cell	cell	NN
cord-261566-fn08b0y2	45	20	damage	damage	NN
cord-261566-fn08b0y2	45	21	which	which	WDT
cord-261566-fn08b0y2	45	22	is	be	VBZ
cord-261566-fn08b0y2	45	23	also	also	RB
cord-261566-fn08b0y2	45	24	accompanied	accompany	VBN
cord-261566-fn08b0y2	45	25	by	by	IN
cord-261566-fn08b0y2	45	26	an	an	DT
cord-261566-fn08b0y2	45	27	exuberant	exuberant	JJ
cord-261566-fn08b0y2	45	28	release	release	NN
cord-261566-fn08b0y2	45	29	of	of	IN
cord-261566-fn08b0y2	45	30	proinflammatory	proinflammatory	JJ
cord-261566-fn08b0y2	45	31	cytokines	cytokine	NNS
cord-261566-fn08b0y2	45	32	and	and	CC
cord-261566-fn08b0y2	45	33	chemokines	chemokine	NNS
cord-261566-fn08b0y2	45	34	.	.	.
cord-261566-fn08b0y2	46	1	15	15	CD
cord-261566-fn08b0y2	47	1	The	the	DT
cord-261566-fn08b0y2	47	2	disease	disease	NN
cord-261566-fn08b0y2	47	3	severity	severity	NN
cord-261566-fn08b0y2	47	4	and	and	CC
cord-261566-fn08b0y2	47	5	lung	lung	NN
cord-261566-fn08b0y2	47	6	damage	damage	NN
cord-261566-fn08b0y2	47	7	in	in	IN
cord-261566-fn08b0y2	47	8	the	the	DT
cord-261566-fn08b0y2	47	9	case	case	NN
cord-261566-fn08b0y2	47	10	of	of	IN
cord-261566-fn08b0y2	47	11	SARS	SARS	NNP
cord-261566-fn08b0y2	47	12	-	-	HYPH
cord-261566-fn08b0y2	47	13	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	47	14	infection	infection	NN
cord-261566-fn08b0y2	47	15	can	can	MD
cord-261566-fn08b0y2	47	16	be	be	VB
cord-261566-fn08b0y2	47	17	directly	directly	RB
cord-261566-fn08b0y2	47	18	correlated	correlate	VBN
cord-261566-fn08b0y2	47	19	with	with	IN
cord-261566-fn08b0y2	47	20	the	the	DT
cord-261566-fn08b0y2	47	21	dysregulated	dysregulate	VBN
cord-261566-fn08b0y2	47	22	immune	immune	JJ
cord-261566-fn08b0y2	47	23	response	response	NN
cord-261566-fn08b0y2	47	24	at	at	IN
cord-261566-fn08b0y2	47	25	7	7	CD
cord-261566-fn08b0y2	47	26	-	-	SYM
cord-261566-fn08b0y2	47	27	10	10	CD
cord-261566-fn08b0y2	47	28	days	day	NNS
cord-261566-fn08b0y2	47	29	after	after	IN
cord-261566-fn08b0y2	47	30	symptom	symptom	NN
cord-261566-fn08b0y2	47	31	onset	onset	NN
cord-261566-fn08b0y2	47	32	and	and	CC
cord-261566-fn08b0y2	47	33	is	be	VBZ
cord-261566-fn08b0y2	47	34	characterized	characterize	VBN
cord-261566-fn08b0y2	47	35	by	by	IN
cord-261566-fn08b0y2	47	36	exuberant	exuberant	JJ
cord-261566-fn08b0y2	47	37	production	production	NN
cord-261566-fn08b0y2	47	38	of	of	IN
cord-261566-fn08b0y2	47	39	cytokines	cytokine	NNS
cord-261566-fn08b0y2	47	40	including	include	VBG
cord-261566-fn08b0y2	47	41	IL-2	IL-2	NNP
cord-261566-fn08b0y2	47	42	,	,	,
cord-261566-fn08b0y2	47	43	IL-7	IL-7	NNP
cord-261566-fn08b0y2	47	44	,	,	,
cord-261566-fn08b0y2	47	45	IL-10	IL-10	NNP
cord-261566-fn08b0y2	47	46	,	,	,
cord-261566-fn08b0y2	47	47	MIP-1A	MIP-1A	NNP
cord-261566-fn08b0y2	47	48	,	,	,
cord-261566-fn08b0y2	47	49	IP-10	IP-10	NNP
cord-261566-fn08b0y2	47	50	,	,	,
cord-261566-fn08b0y2	47	51	and	and	CC
cord-261566-fn08b0y2	47	52	TNF	TNF	NNP
cord-261566-fn08b0y2	47	53	-	-	HYPH
cord-261566-fn08b0y2	47	54	α	α	NNP
cord-261566-fn08b0y2	47	55	.	.	.
cord-261566-fn08b0y2	47	56	3	3	CD
cord-261566-fn08b0y2	47	57	,	,	,
cord-261566-fn08b0y2	47	58	15	15	CD
cord-261566-fn08b0y2	48	1	This	this	DT
cord-261566-fn08b0y2	48	2	'	'	``
cord-261566-fn08b0y2	48	3	cytokine	cytokine	NN
cord-261566-fn08b0y2	48	4	storm	storm	NN
cord-261566-fn08b0y2	48	5	'	'	''
cord-261566-fn08b0y2	48	6	was	be	VBD
cord-261566-fn08b0y2	48	7	also	also	RB
cord-261566-fn08b0y2	48	8	reported	report	VBN
cord-261566-fn08b0y2	48	9	in	in	IN
cord-261566-fn08b0y2	48	10	animal	animal	NN
cord-261566-fn08b0y2	48	11	studies	study	NNS
cord-261566-fn08b0y2	48	12	with	with	IN
cord-261566-fn08b0y2	48	13	SARS	SARS	NNP
cord-261566-fn08b0y2	48	14	-	-	HYPH
cord-261566-fn08b0y2	48	15	CoV	CoV	NNP
cord-261566-fn08b0y2	48	16	infection	infection	NN
cord-261566-fn08b0y2	48	17	and	and	CC
cord-261566-fn08b0y2	48	18	was	be	VBD
cord-261566-fn08b0y2	48	19	responsible	responsible	JJ
cord-261566-fn08b0y2	48	20	for	for	IN
cord-261566-fn08b0y2	48	21	the	the	DT
cord-261566-fn08b0y2	48	22	dampening	dampening	NN
cord-261566-fn08b0y2	48	23	of	of	IN
cord-261566-fn08b0y2	48	24	adaptive	adaptive	JJ
cord-261566-fn08b0y2	48	25	immunity	immunity	NN
cord-261566-fn08b0y2	48	26	of	of	IN
cord-261566-fn08b0y2	48	27	patients	patient	NNS
cord-261566-fn08b0y2	48	28	in	in	IN
cord-261566-fn08b0y2	48	29	the	the	DT
cord-261566-fn08b0y2	48	30	later	later	JJ
cord-261566-fn08b0y2	48	31	phase	phase	NN
cord-261566-fn08b0y2	48	32	of	of	IN
cord-261566-fn08b0y2	48	33	infection	infection	NN
cord-261566-fn08b0y2	48	34	.	.	.
cord-261566-fn08b0y2	49	1	16	16	CD
cord-261566-fn08b0y2	50	1	As	as	IN
cord-261566-fn08b0y2	50	2	of	of	IN
cord-261566-fn08b0y2	50	3	now	now	RB
cord-261566-fn08b0y2	50	4	,	,	,
cord-261566-fn08b0y2	50	5	the	the	DT
cord-261566-fn08b0y2	50	6	spread	spread	NN
cord-261566-fn08b0y2	50	7	of	of	IN
cord-261566-fn08b0y2	50	8	SARS	SARS	NNP
cord-261566-fn08b0y2	50	9	-	-	HYPH
cord-261566-fn08b0y2	50	10	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	50	11	is	be	VBZ
cord-261566-fn08b0y2	50	12	being	be	VBG
cord-261566-fn08b0y2	50	13	quelled	quell	VBN
cord-261566-fn08b0y2	50	14	by	by	IN
cord-261566-fn08b0y2	50	15	strict	strict	JJ
cord-261566-fn08b0y2	50	16	policy	policy	NN
cord-261566-fn08b0y2	50	17	measures	measure	NNS
cord-261566-fn08b0y2	50	18	such	such	JJ
cord-261566-fn08b0y2	50	19	as	as	IN
cord-261566-fn08b0y2	50	20	travel	travel	NN
cord-261566-fn08b0y2	50	21	restrictions	restriction	NNS
cord-261566-fn08b0y2	50	22	,	,	,
cord-261566-fn08b0y2	50	23	social	social	JJ
cord-261566-fn08b0y2	50	24	distancing	distancing	NN
cord-261566-fn08b0y2	50	25	,	,	,
cord-261566-fn08b0y2	50	26	patient	patient	JJ
cord-261566-fn08b0y2	50	27	isolation	isolation	NN
cord-261566-fn08b0y2	50	28	,	,	,
cord-261566-fn08b0y2	50	29	and	and	CC
cord-261566-fn08b0y2	50	30	nationwide	nationwide	JJ
cord-261566-fn08b0y2	50	31	lockdown	lockdown	NN
cord-261566-fn08b0y2	50	32	in	in	IN
cord-261566-fn08b0y2	50	33	several	several	JJ
cord-261566-fn08b0y2	50	34	parts	part	NNS
cord-261566-fn08b0y2	50	35	of	of	IN
cord-261566-fn08b0y2	50	36	the	the	DT
cord-261566-fn08b0y2	50	37	world	world	NN
cord-261566-fn08b0y2	50	38	.	.	.
cord-261566-fn08b0y2	51	1	There	there	EX
cord-261566-fn08b0y2	51	2	are	be	VBP
cord-261566-fn08b0y2	51	3	no	no	DT
cord-261566-fn08b0y2	51	4	approved	approve	VBN
cord-261566-fn08b0y2	51	5	vaccines	vaccine	NNS
cord-261566-fn08b0y2	51	6	available	available	JJ
cord-261566-fn08b0y2	51	7	against	against	IN
cord-261566-fn08b0y2	51	8	any	any	DT
cord-261566-fn08b0y2	51	9	of	of	IN
cord-261566-fn08b0y2	51	10	the	the	DT
cord-261566-fn08b0y2	51	11	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	51	12	.	.	.
cord-261566-fn08b0y2	52	1	This	this	DT
cord-261566-fn08b0y2	52	2	emerging	emerge	VBG
cord-261566-fn08b0y2	52	3	global	global	JJ
cord-261566-fn08b0y2	52	4	pandemic	pandemic	NN
cord-261566-fn08b0y2	52	5	has	have	VBZ
cord-261566-fn08b0y2	52	6	instigated	instigate	VBN
cord-261566-fn08b0y2	52	7	an	an	DT
cord-261566-fn08b0y2	52	8	unprecedented	unprecedented	JJ
cord-261566-fn08b0y2	52	9	search	search	NN
cord-261566-fn08b0y2	52	10	for	for	IN
cord-261566-fn08b0y2	52	11	an	an	DT
cord-261566-fn08b0y2	52	12	effective	effective	JJ
cord-261566-fn08b0y2	52	13	prophylactic	prophylactic	JJ
cord-261566-fn08b0y2	52	14	or	or	CC
cord-261566-fn08b0y2	52	15	therapeutic	therapeutic	JJ
cord-261566-fn08b0y2	52	16	intervention	intervention	NN
cord-261566-fn08b0y2	52	17	against	against	IN
cord-261566-fn08b0y2	52	18	COVID-19	COVID-19	NNP
cord-261566-fn08b0y2	52	19	.	.	.
cord-261566-fn08b0y2	53	1	[	[	-LRB-
cord-261566-fn08b0y2	53	2	17	17	CD
cord-261566-fn08b0y2	53	3	]	]	-RRB-
cord-261566-fn08b0y2	53	4	[	[	-LRB-
cord-261566-fn08b0y2	53	5	18	18	CD
cord-261566-fn08b0y2	53	6	]	]	-RRB-
cord-261566-fn08b0y2	53	7	[	[	-LRB-
cord-261566-fn08b0y2	53	8	19	19	CD
cord-261566-fn08b0y2	53	9	]	]	-RRB-
cord-261566-fn08b0y2	53	10	[	[	-LRB-
cord-261566-fn08b0y2	53	11	20	20	CD
cord-261566-fn08b0y2	53	12	]	]	-RRB-
cord-261566-fn08b0y2	54	1	In	in	IN
cord-261566-fn08b0y2	54	2	this	this	DT
cord-261566-fn08b0y2	54	3	review	review	NN
cord-261566-fn08b0y2	54	4	,	,	,
cord-261566-fn08b0y2	54	5	we	-PRON-	PRP
cord-261566-fn08b0y2	54	6	have	have	VBP
cord-261566-fn08b0y2	54	7	discussed	discuss	VBN
cord-261566-fn08b0y2	54	8	the	the	DT
cord-261566-fn08b0y2	54	9	potential	potential	NN
cord-261566-fn08b0y2	54	10	and	and	CC
cord-261566-fn08b0y2	54	11	challenges	challenge	NNS
cord-261566-fn08b0y2	54	12	for	for	IN
cord-261566-fn08b0y2	54	13	the	the	DT
cord-261566-fn08b0y2	54	14	development	development	NN
cord-261566-fn08b0y2	54	15	of	of	IN
cord-261566-fn08b0y2	54	16	a	a	DT
cord-261566-fn08b0y2	54	17	successful	successful	JJ
cord-261566-fn08b0y2	54	18	mucosal	mucosal	JJ
cord-261566-fn08b0y2	54	19	vaccine	vaccine	NN
cord-261566-fn08b0y2	54	20	against	against	IN
cord-261566-fn08b0y2	54	21	SARS	SARS	NNP
cord-261566-fn08b0y2	54	22	-	-	HYPH
cord-261566-fn08b0y2	54	23	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	54	24	.	.	.
cord-261566-fn08b0y2	55	1	Vaccines	vaccine	NNS
cord-261566-fn08b0y2	55	2	have	have	VBP
cord-261566-fn08b0y2	55	3	been	be	VBN
cord-261566-fn08b0y2	55	4	one	one	CD
cord-261566-fn08b0y2	55	5	of	of	IN
cord-261566-fn08b0y2	55	6	the	the	DT
cord-261566-fn08b0y2	55	7	major	major	JJ
cord-261566-fn08b0y2	55	8	contributors	contributor	NNS
cord-261566-fn08b0y2	55	9	in	in	IN
cord-261566-fn08b0y2	55	10	the	the	DT
cord-261566-fn08b0y2	55	11	eradication	eradication	NN
cord-261566-fn08b0y2	55	12	of	of	IN
cord-261566-fn08b0y2	55	13	most	most	JJS
cord-261566-fn08b0y2	55	14	of	of	IN
cord-261566-fn08b0y2	55	15	the	the	DT
cord-261566-fn08b0y2	55	16	infectious	infectious	JJ
cord-261566-fn08b0y2	55	17	diseases	disease	NNS
cord-261566-fn08b0y2	55	18	in	in	IN
cord-261566-fn08b0y2	55	19	the	the	DT
cord-261566-fn08b0y2	55	20	last	last	JJ
cord-261566-fn08b0y2	55	21	century	century	NN
cord-261566-fn08b0y2	55	22	.	.	.
cord-261566-fn08b0y2	56	1	Vaccination	vaccination	NN
cord-261566-fn08b0y2	56	2	of	of	IN
cord-261566-fn08b0y2	56	3	a	a	DT
cord-261566-fn08b0y2	56	4	population	population	NN
cord-261566-fn08b0y2	56	5	interrupts	interrupt	VBZ
cord-261566-fn08b0y2	56	6	the	the	DT
cord-261566-fn08b0y2	56	7	transmission	transmission	NN
cord-261566-fn08b0y2	56	8	chain	chain	NN
cord-261566-fn08b0y2	56	9	of	of	IN
cord-261566-fn08b0y2	56	10	a	a	DT
cord-261566-fn08b0y2	56	11	communicable	communicable	JJ
cord-261566-fn08b0y2	56	12	pathogen	pathogen	NN
cord-261566-fn08b0y2	56	13	by	by	IN
cord-261566-fn08b0y2	56	14	not	not	RB
cord-261566-fn08b0y2	56	15	only	only	RB
cord-261566-fn08b0y2	56	16	protecting	protect	VBG
cord-261566-fn08b0y2	56	17	the	the	DT
cord-261566-fn08b0y2	56	18	immunized	immunize	VBN
cord-261566-fn08b0y2	56	19	subjects	subject	NNS
cord-261566-fn08b0y2	56	20	but	but	CC
cord-261566-fn08b0y2	56	21	also	also	RB
cord-261566-fn08b0y2	56	22	by	by	IN
cord-261566-fn08b0y2	56	23	halting	halt	VBG
cord-261566-fn08b0y2	56	24	the	the	DT
cord-261566-fn08b0y2	56	25	transmission	transmission	NN
cord-261566-fn08b0y2	56	26	of	of	IN
cord-261566-fn08b0y2	56	27	the	the	DT
cord-261566-fn08b0y2	56	28	virus	virus	NN
cord-261566-fn08b0y2	56	29	by	by	IN
cord-261566-fn08b0y2	56	30	'	'	``
cord-261566-fn08b0y2	56	31	breaking	break	VBG
cord-261566-fn08b0y2	56	32	the	the	DT
cord-261566-fn08b0y2	56	33	chain	chain	NN
cord-261566-fn08b0y2	56	34	'	'	''
cord-261566-fn08b0y2	56	35	within	within	IN
cord-261566-fn08b0y2	56	36	a	a	DT
cord-261566-fn08b0y2	56	37	population	population	NN
cord-261566-fn08b0y2	56	38	by	by	IN
cord-261566-fn08b0y2	56	39	induction	induction	NN
cord-261566-fn08b0y2	56	40	of	of	IN
cord-261566-fn08b0y2	56	41	herd	herd	NN
cord-261566-fn08b0y2	56	42	immunity	immunity	NN
cord-261566-fn08b0y2	56	43	in	in	IN
cord-261566-fn08b0y2	56	44	the	the	DT
cord-261566-fn08b0y2	56	45	vaccine	vaccine	NN
cord-261566-fn08b0y2	56	46	recipients	recipient	NNS
cord-261566-fn08b0y2	56	47	.	.	.
cord-261566-fn08b0y2	57	1	Vaccines	vaccine	NNS
cord-261566-fn08b0y2	57	2	can	can	MD
cord-261566-fn08b0y2	57	3	be	be	VB
cord-261566-fn08b0y2	57	4	administered	administer	VBN
cord-261566-fn08b0y2	57	5	by	by	IN
cord-261566-fn08b0y2	57	6	either	either	DT
cord-261566-fn08b0y2	57	7	intramuscular	intramuscular	JJ
cord-261566-fn08b0y2	57	8	or	or	CC
cord-261566-fn08b0y2	57	9	subcutaneous	subcutaneous	JJ
cord-261566-fn08b0y2	57	10	injection	injection	NN
cord-261566-fn08b0y2	57	11	to	to	TO
cord-261566-fn08b0y2	57	12	introduce	introduce	VB
cord-261566-fn08b0y2	57	13	them	-PRON-	PRP
cord-261566-fn08b0y2	57	14	into	into	IN
cord-261566-fn08b0y2	57	15	the	the	DT
cord-261566-fn08b0y2	57	16	systemic	systemic	JJ
cord-261566-fn08b0y2	57	17	circulation	circulation	NN
cord-261566-fn08b0y2	57	18	.	.	.
cord-261566-fn08b0y2	58	1	Vaccination	vaccination	NN
cord-261566-fn08b0y2	58	2	through	through	IN
cord-261566-fn08b0y2	58	3	systemic	systemic	JJ
cord-261566-fn08b0y2	58	4	routes	route	NNS
cord-261566-fn08b0y2	58	5	elicits	elicit	VBZ
cord-261566-fn08b0y2	58	6	strong	strong	JJ
cord-261566-fn08b0y2	58	7	systemic	systemic	JJ
cord-261566-fn08b0y2	58	8	immune	immune	JJ
cord-261566-fn08b0y2	58	9	response	response	NN
cord-261566-fn08b0y2	58	10	but	but	CC
cord-261566-fn08b0y2	58	11	is	be	VBZ
cord-261566-fn08b0y2	58	12	not	not	RB
cord-261566-fn08b0y2	58	13	effective	effective	JJ
cord-261566-fn08b0y2	58	14	in	in	IN
cord-261566-fn08b0y2	58	15	generating	generate	VBG
cord-261566-fn08b0y2	58	16	efficient	efficient	JJ
cord-261566-fn08b0y2	58	17	mucosal	mucosal	JJ
cord-261566-fn08b0y2	58	18	immunity	immunity	NN
cord-261566-fn08b0y2	58	19	.	.	.
cord-261566-fn08b0y2	59	1	21	21	CD
cord-261566-fn08b0y2	60	1	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	60	2	vaccines	vaccine	NNS
cord-261566-fn08b0y2	60	3	are	be	VBP
cord-261566-fn08b0y2	60	4	advantageous	advantageous	JJ
cord-261566-fn08b0y2	60	5	not	not	RB
cord-261566-fn08b0y2	60	6	just	just	RB
cord-261566-fn08b0y2	60	7	in	in	IN
cord-261566-fn08b0y2	60	8	evoking	evoke	VBG
cord-261566-fn08b0y2	60	9	strong	strong	JJ
cord-261566-fn08b0y2	60	10	immune	immune	JJ
cord-261566-fn08b0y2	60	11	response	response	NN
cord-261566-fn08b0y2	60	12	at	at	IN
cord-261566-fn08b0y2	60	13	both	both	DT
cord-261566-fn08b0y2	60	14	mucosal	mucosal	JJ
cord-261566-fn08b0y2	60	15	sites	site	NNS
cord-261566-fn08b0y2	60	16	and	and	CC
cord-261566-fn08b0y2	60	17	systemic	systemic	JJ
cord-261566-fn08b0y2	60	18	circulation	circulation	NN
cord-261566-fn08b0y2	60	19	but	but	CC
cord-261566-fn08b0y2	60	20	also	also	RB
cord-261566-fn08b0y2	60	21	offer	offer	VBP
cord-261566-fn08b0y2	60	22	greater	great	JJR
cord-261566-fn08b0y2	60	23	practicality	practicality	NN
cord-261566-fn08b0y2	60	24	in	in	IN
cord-261566-fn08b0y2	60	25	terms	term	NNS
cord-261566-fn08b0y2	60	26	of	of	IN
cord-261566-fn08b0y2	60	27	cost	cost	NN
cord-261566-fn08b0y2	60	28	and	and	CC
cord-261566-fn08b0y2	60	29	administration	administration	NN
cord-261566-fn08b0y2	60	30	.	.	.
cord-261566-fn08b0y2	61	1	22	22	CD
cord-261566-fn08b0y2	62	1	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	62	2	vaccines	vaccine	NNS
cord-261566-fn08b0y2	62	3	can	can	MD
cord-261566-fn08b0y2	62	4	be	be	VB
cord-261566-fn08b0y2	62	5	produced	produce	VBN
cord-261566-fn08b0y2	62	6	at	at	IN
cord-261566-fn08b0y2	62	7	considerably	considerably	RB
cord-261566-fn08b0y2	62	8	low	low	JJ
cord-261566-fn08b0y2	62	9	cost	cost	NN
cord-261566-fn08b0y2	62	10	for	for	IN
cord-261566-fn08b0y2	62	11	mass	mass	NN
cord-261566-fn08b0y2	62	12	immunization	immunization	NN
cord-261566-fn08b0y2	62	13	,	,	,
cord-261566-fn08b0y2	62	14	the	the	DT
cord-261566-fn08b0y2	62	15	administration	administration	NN
cord-261566-fn08b0y2	62	16	is	be	VBZ
cord-261566-fn08b0y2	62	17	needle	needle	NN
cord-261566-fn08b0y2	62	18	-	-	HYPH
cord-261566-fn08b0y2	62	19	free	free	JJ
cord-261566-fn08b0y2	62	20	and	and	CC
cord-261566-fn08b0y2	62	21	convenient	convenient	JJ
cord-261566-fn08b0y2	62	22	compared	compare	VBN
cord-261566-fn08b0y2	62	23	to	to	IN
cord-261566-fn08b0y2	62	24	systemic	systemic	JJ
cord-261566-fn08b0y2	62	25	vaccines	vaccine	NNS
cord-261566-fn08b0y2	62	26	.	.	.
cord-261566-fn08b0y2	63	1	23	23	CD
cord-261566-fn08b0y2	63	2	Majority	majority	NN
cord-261566-fn08b0y2	63	3	of	of	IN
cord-261566-fn08b0y2	63	4	mucosal	mucosal	JJ
cord-261566-fn08b0y2	63	5	vaccines	vaccine	NNS
cord-261566-fn08b0y2	63	6	are	be	VBP
cord-261566-fn08b0y2	63	7	administered	administer	VBN
cord-261566-fn08b0y2	63	8	through	through	IN
cord-261566-fn08b0y2	63	9	oral	oral	JJ
cord-261566-fn08b0y2	63	10	or	or	CC
cord-261566-fn08b0y2	63	11	intranasal	intranasal	JJ
cord-261566-fn08b0y2	63	12	routes	route	NNS
cord-261566-fn08b0y2	63	13	while	while	IN
cord-261566-fn08b0y2	63	14	rectal	rectal	JJ
cord-261566-fn08b0y2	63	15	,	,	,
cord-261566-fn08b0y2	63	16	vaginal	vaginal	JJ
cord-261566-fn08b0y2	63	17	,	,	,
cord-261566-fn08b0y2	63	18	ocular	ocular	JJ
cord-261566-fn08b0y2	63	19	,	,	,
cord-261566-fn08b0y2	63	20	and	and	CC
cord-261566-fn08b0y2	63	21	sublingual	sublingual	NN
cord-261566-fn08b0y2	63	22	routes	route	NNS
cord-261566-fn08b0y2	63	23	can	can	MD
cord-261566-fn08b0y2	63	24	also	also	RB
cord-261566-fn08b0y2	63	25	be	be	VB
cord-261566-fn08b0y2	63	26	used	use	VBN
cord-261566-fn08b0y2	63	27	.	.	.
cord-261566-fn08b0y2	64	1	The	the	DT
cord-261566-fn08b0y2	64	2	selection	selection	NN
cord-261566-fn08b0y2	64	3	of	of	IN
cord-261566-fn08b0y2	64	4	administration	administration	NN
cord-261566-fn08b0y2	64	5	route	route	NN
cord-261566-fn08b0y2	64	6	depends	depend	VBZ
cord-261566-fn08b0y2	64	7	on	on	IN
cord-261566-fn08b0y2	64	8	the	the	DT
cord-261566-fn08b0y2	64	9	nature	nature	NN
cord-261566-fn08b0y2	64	10	of	of	IN
cord-261566-fn08b0y2	64	11	the	the	DT
cord-261566-fn08b0y2	64	12	antigen	antigen	NN
cord-261566-fn08b0y2	64	13	and	and	CC
cord-261566-fn08b0y2	64	14	the	the	DT
cord-261566-fn08b0y2	64	15	desired	desire	VBN
cord-261566-fn08b0y2	64	16	site	site	NN
cord-261566-fn08b0y2	64	17	for	for	IN
cord-261566-fn08b0y2	64	18	induction	induction	NN
cord-261566-fn08b0y2	64	19	of	of	IN
cord-261566-fn08b0y2	64	20	immune	immune	JJ
cord-261566-fn08b0y2	64	21	response	response	NN
cord-261566-fn08b0y2	64	22	.	.	.
cord-261566-fn08b0y2	65	1	Upon	upon	IN
cord-261566-fn08b0y2	65	2	oral	oral	JJ
cord-261566-fn08b0y2	65	3	immunization	immunization	NN
cord-261566-fn08b0y2	65	4	,	,	,
cord-261566-fn08b0y2	65	5	immune	immune	JJ
cord-261566-fn08b0y2	65	6	responses	response	NNS
cord-261566-fn08b0y2	65	7	are	be	VBP
cord-261566-fn08b0y2	65	8	induced	induce	VBN
cord-261566-fn08b0y2	65	9	strongly	strongly	RB
cord-261566-fn08b0y2	65	10	in	in	IN
cord-261566-fn08b0y2	65	11	gastrointestinal	gastrointestinal	JJ
cord-261566-fn08b0y2	65	12	(	(	-LRB-
cord-261566-fn08b0y2	65	13	GI	GI	NNP
cord-261566-fn08b0y2	65	14	)	)	-RRB-
cord-261566-fn08b0y2	65	15	tract	tract	NN
cord-261566-fn08b0y2	65	16	,	,	,
cord-261566-fn08b0y2	65	17	mammary	mammary	JJ
cord-261566-fn08b0y2	65	18	glands	gland	NNS
cord-261566-fn08b0y2	65	19	,	,	,
cord-261566-fn08b0y2	65	20	and	and	CC
cord-261566-fn08b0y2	65	21	salivary	salivary	NN
cord-261566-fn08b0y2	65	22	glands	gland	NNS
cord-261566-fn08b0y2	65	23	while	while	IN
cord-261566-fn08b0y2	65	24	intranasal	intranasal	NN
cord-261566-fn08b0y2	65	25	vaccination	vaccination	NN
cord-261566-fn08b0y2	65	26	induces	induce	VBZ
cord-261566-fn08b0y2	65	27	marked	mark	VBD
cord-261566-fn08b0y2	65	28	antigen	antigen	NN
cord-261566-fn08b0y2	65	29	-	-	HYPH
cord-261566-fn08b0y2	65	30	specific	specific	JJ
cord-261566-fn08b0y2	65	31	immune	immune	JJ
cord-261566-fn08b0y2	65	32	response	response	NN
cord-261566-fn08b0y2	65	33	in	in	IN
cord-261566-fn08b0y2	65	34	respiratory	respiratory	NN
cord-261566-fn08b0y2	65	35	,	,	,
cord-261566-fn08b0y2	65	36	GI	GI	NNP
cord-261566-fn08b0y2	65	37	,	,	,
cord-261566-fn08b0y2	65	38	and	and	CC
cord-261566-fn08b0y2	65	39	genital	genital	JJ
cord-261566-fn08b0y2	65	40	tracts	tract	NNS
cord-261566-fn08b0y2	65	41	.	.	.
cord-261566-fn08b0y2	66	1	The	the	DT
cord-261566-fn08b0y2	66	2	primary	primary	JJ
cord-261566-fn08b0y2	66	3	mode	mode	NN
cord-261566-fn08b0y2	66	4	of	of	IN
cord-261566-fn08b0y2	66	5	transmission	transmission	NN
cord-261566-fn08b0y2	66	6	of	of	IN
cord-261566-fn08b0y2	66	7	SARS	SARS	NNP
cord-261566-fn08b0y2	66	8	-	-	HYPH
cord-261566-fn08b0y2	66	9	CoV	CoV	NNP
cord-261566-fn08b0y2	66	10	is	be	VBZ
cord-261566-fn08b0y2	66	11	through	through	IN
cord-261566-fn08b0y2	66	12	mucosal	mucosal	JJ
cord-261566-fn08b0y2	66	13	membranes	membrane	NNS
cord-261566-fn08b0y2	66	14	of	of	IN
cord-261566-fn08b0y2	66	15	the	the	DT
cord-261566-fn08b0y2	66	16	eyes	eye	NNS
cord-261566-fn08b0y2	66	17	,	,	,
cord-261566-fn08b0y2	66	18	nose	nose	NN
cord-261566-fn08b0y2	66	19	,	,	,
cord-261566-fn08b0y2	66	20	or	or	CC
cord-261566-fn08b0y2	66	21	mouth	mouth	NN
cord-261566-fn08b0y2	66	22	.	.	.
cord-261566-fn08b0y2	67	1	24	24	CD
cord-261566-fn08b0y2	67	2	Studies	study	NNS
cord-261566-fn08b0y2	67	3	with	with	IN
cord-261566-fn08b0y2	67	4	S	S	NNP
cord-261566-fn08b0y2	67	5	protein	protein	NN
cord-261566-fn08b0y2	67	6	of	of	IN
cord-261566-fn08b0y2	67	7	SARS	SARS	NNP
cord-261566-fn08b0y2	67	8	-	-	HYPH
cord-261566-fn08b0y2	67	9	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	67	10	have	have	VBP
cord-261566-fn08b0y2	67	11	revealed	reveal	VBN
cord-261566-fn08b0y2	67	12	that	that	IN
cord-261566-fn08b0y2	67	13	it	-PRON-	PRP
cord-261566-fn08b0y2	67	14	also	also	RB
cord-261566-fn08b0y2	67	15	recognizes	recognize	VBZ
cord-261566-fn08b0y2	67	16	human	human	JJ
cord-261566-fn08b0y2	67	17	ACE2	ACE2	NNP
cord-261566-fn08b0y2	67	18	(	(	-LRB-
cord-261566-fn08b0y2	67	19	hACE2	hace2	NN
cord-261566-fn08b0y2	67	20	)	)	-RRB-
cord-261566-fn08b0y2	67	21	receptor	receptor	NN
cord-261566-fn08b0y2	67	22	on	on	IN
cord-261566-fn08b0y2	67	23	the	the	DT
cord-261566-fn08b0y2	67	24	host	host	NN
cord-261566-fn08b0y2	67	25	cells	cell	NNS
cord-261566-fn08b0y2	67	26	similar	similar	JJ
cord-261566-fn08b0y2	67	27	to	to	IN
cord-261566-fn08b0y2	67	28	SARS	SARS	NNP
cord-261566-fn08b0y2	68	1	-CoV.	-CoV.	:
cord-261566-fn08b0y2	68	2	[	[	-LRB-
cord-261566-fn08b0y2	68	3	25	25	CD
cord-261566-fn08b0y2	68	4	]	]	-RRB-
cord-261566-fn08b0y2	68	5	[	[	-LRB-
cord-261566-fn08b0y2	68	6	26	26	CD
cord-261566-fn08b0y2	68	7	]	]	-RRB-
cord-261566-fn08b0y2	68	8	[	[	-LRB-
cord-261566-fn08b0y2	68	9	27	27	CD
cord-261566-fn08b0y2	68	10	]	]	-RRB-
cord-261566-fn08b0y2	69	1	ACE2	ACE2	NNP
cord-261566-fn08b0y2	69	2	is	be	VBZ
cord-261566-fn08b0y2	69	3	abundantly	abundantly	RB
cord-261566-fn08b0y2	69	4	expressed	express	VBN
cord-261566-fn08b0y2	69	5	in	in	IN
cord-261566-fn08b0y2	69	6	nasal	nasal	NN
cord-261566-fn08b0y2	69	7	and	and	CC
cord-261566-fn08b0y2	69	8	oral	oral	JJ
cord-261566-fn08b0y2	69	9	mucosa	mucosa	NN
cord-261566-fn08b0y2	69	10	rendering	render	VBG
cord-261566-fn08b0y2	69	11	them	-PRON-	PRP
cord-261566-fn08b0y2	69	12	the	the	DT
cord-261566-fn08b0y2	69	13	primary	primary	JJ
cord-261566-fn08b0y2	69	14	targets	target	NNS
cord-261566-fn08b0y2	69	15	for	for	IN
cord-261566-fn08b0y2	69	16	the	the	DT
cord-261566-fn08b0y2	69	17	viral	viral	JJ
cord-261566-fn08b0y2	69	18	entry	entry	NN
cord-261566-fn08b0y2	69	19	and	and	CC
cord-261566-fn08b0y2	69	20	dissemination	dissemination	NN
cord-261566-fn08b0y2	69	21	of	of	IN
cord-261566-fn08b0y2	69	22	SARS	SARS	NNP
cord-261566-fn08b0y2	69	23	-	-	HYPH
cord-261566-fn08b0y2	69	24	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	69	25	.	.	.
cord-261566-fn08b0y2	70	1	28	28	CD
cord-261566-fn08b0y2	71	1	Concomitant	concomitant	JJ
cord-261566-fn08b0y2	71	2	gastrointestinal	gastrointestinal	JJ
cord-261566-fn08b0y2	71	3	symptoms	symptom	NNS
cord-261566-fn08b0y2	71	4	are	be	VBP
cord-261566-fn08b0y2	71	5	reported	report	VBN
cord-261566-fn08b0y2	71	6	in	in	IN
cord-261566-fn08b0y2	71	7	confirmed	confirm	VBN
cord-261566-fn08b0y2	71	8	COVID-19	covid-19	CD
cord-261566-fn08b0y2	71	9	patients	patient	NNS
cord-261566-fn08b0y2	71	10	along	along	IN
cord-261566-fn08b0y2	71	11	with	with	IN
cord-261566-fn08b0y2	71	12	pulmonary	pulmonary	JJ
cord-261566-fn08b0y2	71	13	pathology	pathology	NN
cord-261566-fn08b0y2	71	14	,	,	,
cord-261566-fn08b0y2	71	15	characteristic	characteristic	NN
cord-261566-fn08b0y2	71	16	of	of	IN
cord-261566-fn08b0y2	71	17	SARS	SARS	NNP
cord-261566-fn08b0y2	71	18	-	-	HYPH
cord-261566-fn08b0y2	71	19	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	71	20	infection	infection	NN
cord-261566-fn08b0y2	71	21	.	.	.
cord-261566-fn08b0y2	72	1	The	the	DT
cord-261566-fn08b0y2	72	2	occurrence	occurrence	NN
cord-261566-fn08b0y2	72	3	of	of	IN
cord-261566-fn08b0y2	72	4	acute	acute	JJ
cord-261566-fn08b0y2	72	5	hemorrhagic	hemorrhagic	JJ
cord-261566-fn08b0y2	72	6	colitis	colitis	NN
cord-261566-fn08b0y2	72	7	in	in	IN
cord-261566-fn08b0y2	72	8	a	a	DT
cord-261566-fn08b0y2	72	9	few	few	JJ
cord-261566-fn08b0y2	72	10	cases	case	NNS
cord-261566-fn08b0y2	72	11	and	and	CC
cord-261566-fn08b0y2	72	12	the	the	DT
cord-261566-fn08b0y2	72	13	presence	presence	NN
cord-261566-fn08b0y2	72	14	of	of	IN
cord-261566-fn08b0y2	72	15	SARS	SARS	NNP
cord-261566-fn08b0y2	72	16	-	-	HYPH
cord-261566-fn08b0y2	72	17	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	72	18	RNA	RNA	NNP
cord-261566-fn08b0y2	72	19	in	in	IN
cord-261566-fn08b0y2	72	20	fecal	fecal	JJ
cord-261566-fn08b0y2	72	21	samples	sample	NNS
cord-261566-fn08b0y2	72	22	of	of	IN
cord-261566-fn08b0y2	72	23	COVID-19	covid-19	CD
cord-261566-fn08b0y2	72	24	patients	patient	NNS
cord-261566-fn08b0y2	72	25	indicate	indicate	VBP
cord-261566-fn08b0y2	72	26	enteric	enteric	JJ
cord-261566-fn08b0y2	72	27	involvement	involvement	NN
cord-261566-fn08b0y2	72	28	in	in	IN
cord-261566-fn08b0y2	72	29	COVID-19	COVID-19	NNP
cord-261566-fn08b0y2	72	30	reasserting	reassert	VBG
cord-261566-fn08b0y2	72	31	the	the	DT
cord-261566-fn08b0y2	72	32	similarity	similarity	NN
cord-261566-fn08b0y2	72	33	in	in	IN
cord-261566-fn08b0y2	72	34	tissue	tissue	NN
cord-261566-fn08b0y2	72	35	tropism	tropism	NN
cord-261566-fn08b0y2	72	36	with	with	IN
cord-261566-fn08b0y2	72	37	SARS	SARS	NNP
cord-261566-fn08b0y2	72	38	-	-	HYPH
cord-261566-fn08b0y2	72	39	CoV.	CoV.	NNP
cord-261566-fn08b0y2	72	40	[	[	-LRB-
cord-261566-fn08b0y2	72	41	29	29	CD
cord-261566-fn08b0y2	72	42	]	]	-RRB-
cord-261566-fn08b0y2	72	43	[	[	-LRB-
cord-261566-fn08b0y2	72	44	30	30	CD
cord-261566-fn08b0y2	72	45	]	]	-RRB-
cord-261566-fn08b0y2	72	46	[	[	-LRB-
cord-261566-fn08b0y2	72	47	31	31	CD
cord-261566-fn08b0y2	72	48	]	]	-RRB-
cord-261566-fn08b0y2	73	1	Considering	consider	VBG
cord-261566-fn08b0y2	73	2	the	the	DT
cord-261566-fn08b0y2	73	3	prominent	prominent	JJ
cord-261566-fn08b0y2	73	4	role	role	NN
cord-261566-fn08b0y2	73	5	of	of	IN
cord-261566-fn08b0y2	73	6	nasal	nasal	NN
cord-261566-fn08b0y2	73	7	and	and	CC
cord-261566-fn08b0y2	73	8	gastric	gastric	JJ
cord-261566-fn08b0y2	73	9	mucosa	mucosa	NN
cord-261566-fn08b0y2	73	10	in	in	IN
cord-261566-fn08b0y2	73	11	the	the	DT
cord-261566-fn08b0y2	73	12	transmission	transmission	NN
cord-261566-fn08b0y2	73	13	and	and	CC
cord-261566-fn08b0y2	73	14	the	the	DT
cord-261566-fn08b0y2	73	15	clinical	clinical	JJ
cord-261566-fn08b0y2	73	16	progression	progression	NN
cord-261566-fn08b0y2	73	17	of	of	IN
cord-261566-fn08b0y2	73	18	SARS	SARS	NNP
cord-261566-fn08b0y2	73	19	-	-	HYPH
cord-261566-fn08b0y2	73	20	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	73	21	,	,	,
cord-261566-fn08b0y2	73	22	mucosal	mucosal	JJ
cord-261566-fn08b0y2	73	23	immunization	immunization	NN
cord-261566-fn08b0y2	73	24	using	use	VBG
cord-261566-fn08b0y2	73	25	oral	oral	JJ
cord-261566-fn08b0y2	73	26	or	or	CC
cord-261566-fn08b0y2	73	27	intranasal	intranasal	JJ
cord-261566-fn08b0y2	73	28	vaccine	vaccine	NN
cord-261566-fn08b0y2	73	29	could	could	MD
cord-261566-fn08b0y2	73	30	be	be	VB
cord-261566-fn08b0y2	73	31	an	an	DT
cord-261566-fn08b0y2	73	32	effective	effective	JJ
cord-261566-fn08b0y2	73	33	strategy	strategy	NN
cord-261566-fn08b0y2	73	34	for	for	IN
cord-261566-fn08b0y2	73	35	immunoprophylaxis	immunoprophylaxis	NNP
cord-261566-fn08b0y2	73	36	against	against	IN
cord-261566-fn08b0y2	73	37	SARS	SARS	NNP
cord-261566-fn08b0y2	73	38	-	-	HYPH
cord-261566-fn08b0y2	73	39	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	73	40	.	.	.
cord-261566-fn08b0y2	74	1	Vaccination	vaccination	NN
cord-261566-fn08b0y2	74	2	at	at	IN
cord-261566-fn08b0y2	74	3	the	the	DT
cord-261566-fn08b0y2	74	4	entry	entry	NN
cord-261566-fn08b0y2	74	5	site	site	NN
cord-261566-fn08b0y2	74	6	such	such	JJ
cord-261566-fn08b0y2	74	7	as	as	IN
cord-261566-fn08b0y2	74	8	intranasal	intranasal	JJ
cord-261566-fn08b0y2	74	9	or	or	CC
cord-261566-fn08b0y2	74	10	oral	oral	JJ
cord-261566-fn08b0y2	74	11	immunization	immunization	NN
cord-261566-fn08b0y2	74	12	induces	induce	VBZ
cord-261566-fn08b0y2	74	13	a	a	DT
cord-261566-fn08b0y2	74	14	strong	strong	JJ
cord-261566-fn08b0y2	74	15	local	local	JJ
cord-261566-fn08b0y2	74	16	immune	immune	JJ
cord-261566-fn08b0y2	74	17	response	response	NN
cord-261566-fn08b0y2	74	18	in	in	IN
cord-261566-fn08b0y2	74	19	the	the	DT
cord-261566-fn08b0y2	74	20	case	case	NN
cord-261566-fn08b0y2	74	21	of	of	IN
cord-261566-fn08b0y2	74	22	SARS	SARS	NNP
cord-261566-fn08b0y2	74	23	-	-	HYPH
cord-261566-fn08b0y2	74	24	CoV.	CoV.	NNP
cord-261566-fn08b0y2	74	25	32	32	CD
cord-261566-fn08b0y2	74	26	,	,	,
cord-261566-fn08b0y2	74	27	33	33	CD
cord-261566-fn08b0y2	75	1	Consequently	consequently	RB
cord-261566-fn08b0y2	75	2	,	,	,
cord-261566-fn08b0y2	75	3	vaccination	vaccination	NN
cord-261566-fn08b0y2	75	4	at	at	IN
cord-261566-fn08b0y2	75	5	the	the	DT
cord-261566-fn08b0y2	75	6	mucosal	mucosal	JJ
cord-261566-fn08b0y2	75	7	sites	site	NNS
cord-261566-fn08b0y2	75	8	reduces	reduce	VBZ
cord-261566-fn08b0y2	75	9	the	the	DT
cord-261566-fn08b0y2	75	10	risk	risk	NN
cord-261566-fn08b0y2	75	11	of	of	IN
cord-261566-fn08b0y2	75	12	antibodydependent	antibodydependent	NN
cord-261566-fn08b0y2	75	13	disease	disease	NN
cord-261566-fn08b0y2	75	14	enhancement	enhancement	NN
cord-261566-fn08b0y2	75	15	(	(	-LRB-
cord-261566-fn08b0y2	75	16	ADE	ADE	NNP
cord-261566-fn08b0y2	75	17	)	)	-RRB-
cord-261566-fn08b0y2	75	18	by	by	IN
cord-261566-fn08b0y2	75	19	blocking	block	VBG
cord-261566-fn08b0y2	75	20	the	the	DT
cord-261566-fn08b0y2	75	21	virus	virus	NN
cord-261566-fn08b0y2	75	22	at	at	IN
cord-261566-fn08b0y2	75	23	the	the	DT
cord-261566-fn08b0y2	75	24	entry	entry	NN
cord-261566-fn08b0y2	75	25	site	site	NN
cord-261566-fn08b0y2	75	26	.	.	.
cord-261566-fn08b0y2	76	1	Administration	administration	NN
cord-261566-fn08b0y2	76	2	of	of	IN
cord-261566-fn08b0y2	76	3	mucosal	mucosal	JJ
cord-261566-fn08b0y2	76	4	vaccine	vaccine	NN
cord-261566-fn08b0y2	76	5	has	have	VBZ
cord-261566-fn08b0y2	76	6	also	also	RB
cord-261566-fn08b0y2	76	7	been	be	VBN
cord-261566-fn08b0y2	76	8	shown	show	VBN
cord-261566-fn08b0y2	76	9	to	to	TO
cord-261566-fn08b0y2	76	10	elicit	elicit	VB
cord-261566-fn08b0y2	76	11	strong	strong	JJ
cord-261566-fn08b0y2	76	12	systemic	systemic	JJ
cord-261566-fn08b0y2	76	13	humoral	humoral	JJ
cord-261566-fn08b0y2	76	14	immunity	immunity	NN
cord-261566-fn08b0y2	76	15	thereby	thereby	RB
cord-261566-fn08b0y2	76	16	neutralizing	neutralize	VBG
cord-261566-fn08b0y2	76	17	any	any	DT
cord-261566-fn08b0y2	76	18	virus	virus	NN
cord-261566-fn08b0y2	76	19	particle	particle	NN
cord-261566-fn08b0y2	76	20	that	that	WDT
cord-261566-fn08b0y2	76	21	evades	evade	VBZ
cord-261566-fn08b0y2	76	22	the	the	DT
cord-261566-fn08b0y2	76	23	primary	primary	JJ
cord-261566-fn08b0y2	76	24	immune	immune	JJ
cord-261566-fn08b0y2	76	25	response	response	NN
cord-261566-fn08b0y2	76	26	at	at	IN
cord-261566-fn08b0y2	76	27	the	the	DT
cord-261566-fn08b0y2	76	28	mucosal	mucosal	JJ
cord-261566-fn08b0y2	76	29	site	site	NN
cord-261566-fn08b0y2	76	30	.	.	.
cord-261566-fn08b0y2	77	1	Currently	currently	RB
cord-261566-fn08b0y2	77	2	,	,	,
cord-261566-fn08b0y2	77	3	several	several	JJ
cord-261566-fn08b0y2	77	4	strategies	strategy	NNS
cord-261566-fn08b0y2	77	5	are	be	VBP
cord-261566-fn08b0y2	77	6	being	be	VBG
cord-261566-fn08b0y2	77	7	examined	examine	VBN
cord-261566-fn08b0y2	77	8	for	for	IN
cord-261566-fn08b0y2	77	9	the	the	DT
cord-261566-fn08b0y2	77	10	development	development	NN
cord-261566-fn08b0y2	77	11	of	of	IN
cord-261566-fn08b0y2	77	12	a	a	DT
cord-261566-fn08b0y2	77	13	mucosal	mucosal	JJ
cord-261566-fn08b0y2	77	14	vaccine	vaccine	NN
cord-261566-fn08b0y2	77	15	against	against	IN
cord-261566-fn08b0y2	77	16	SARS	SARS	NNP
cord-261566-fn08b0y2	77	17	-	-	HYPH
cord-261566-fn08b0y2	77	18	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	77	19	.	.	.
cord-261566-fn08b0y2	78	1	34	34	CD
cord-261566-fn08b0y2	79	1	A	a	DT
cord-261566-fn08b0y2	79	2	unique	unique	JJ
cord-261566-fn08b0y2	79	3	mucosal	mucosal	NN
cord-261566-fn08b0y2	79	4	system	system	NN
cord-261566-fn08b0y2	79	5	exists	exist	VBZ
cord-261566-fn08b0y2	79	6	independent	independent	JJ
cord-261566-fn08b0y2	79	7	of	of	IN
cord-261566-fn08b0y2	79	8	the	the	DT
cord-261566-fn08b0y2	79	9	systemic	systemic	JJ
cord-261566-fn08b0y2	79	10	immune	immune	JJ
cord-261566-fn08b0y2	79	11	system	system	NN
cord-261566-fn08b0y2	79	12	to	to	TO
cord-261566-fn08b0y2	79	13	protect	protect	VB
cord-261566-fn08b0y2	79	14	exposed	expose	VBN
cord-261566-fn08b0y2	79	15	mucosal	mucosal	JJ
cord-261566-fn08b0y2	79	16	surfaces	surface	NNS
cord-261566-fn08b0y2	79	17	against	against	IN
cord-261566-fn08b0y2	79	18	environmental	environmental	JJ
cord-261566-fn08b0y2	79	19	antigens	antigen	NNS
cord-261566-fn08b0y2	79	20	and	and	CC
cord-261566-fn08b0y2	79	21	downregulation	downregulation	NN
cord-261566-fn08b0y2	79	22	of	of	IN
cord-261566-fn08b0y2	79	23	systemic	systemic	JJ
cord-261566-fn08b0y2	79	24	immune	immune	JJ
cord-261566-fn08b0y2	79	25	responses	response	NNS
cord-261566-fn08b0y2	79	26	.	.	.
cord-261566-fn08b0y2	80	1	It	-PRON-	PRP
cord-261566-fn08b0y2	80	2	acts	act	VBZ
cord-261566-fn08b0y2	80	3	as	as	IN
cord-261566-fn08b0y2	80	4	the	the	DT
cord-261566-fn08b0y2	80	5	first	first	JJ
cord-261566-fn08b0y2	80	6	line	line	NN
cord-261566-fn08b0y2	80	7	of	of	IN
cord-261566-fn08b0y2	80	8	defense	defense	NN
cord-261566-fn08b0y2	80	9	against	against	IN
cord-261566-fn08b0y2	80	10	most	most	JJS
cord-261566-fn08b0y2	80	11	of	of	IN
cord-261566-fn08b0y2	80	12	the	the	DT
cord-261566-fn08b0y2	80	13	antigens	antigen	NNS
cord-261566-fn08b0y2	80	14	and	and	CC
cord-261566-fn08b0y2	80	15	prevents	prevent	VBZ
cord-261566-fn08b0y2	80	16	them	-PRON-	PRP
cord-261566-fn08b0y2	80	17	from	from	IN
cord-261566-fn08b0y2	80	18	evoking	evoke	VBG
cord-261566-fn08b0y2	80	19	systemic	systemic	JJ
cord-261566-fn08b0y2	80	20	immune	immune	JJ
cord-261566-fn08b0y2	80	21	system	system	NN
cord-261566-fn08b0y2	80	22	.	.	.
cord-261566-fn08b0y2	81	1	35	35	CD
cord-261566-fn08b0y2	82	1	The	the	DT
cord-261566-fn08b0y2	82	2	mucosal	mucosal	JJ
cord-261566-fn08b0y2	82	3	system	system	NN
cord-261566-fn08b0y2	82	4	serves	serve	VBZ
cord-261566-fn08b0y2	82	5	as	as	IN
cord-261566-fn08b0y2	82	6	the	the	DT
cord-261566-fn08b0y2	82	7	most	most	RBS
cord-261566-fn08b0y2	82	8	common	common	JJ
cord-261566-fn08b0y2	82	9	portal	portal	NN
cord-261566-fn08b0y2	82	10	for	for	IN
cord-261566-fn08b0y2	82	11	pathogen	pathogen	NN
cord-261566-fn08b0y2	82	12	entry	entry	NN
cord-261566-fn08b0y2	82	13	in	in	IN
cord-261566-fn08b0y2	82	14	the	the	DT
cord-261566-fn08b0y2	82	15	human	human	JJ
cord-261566-fn08b0y2	82	16	body	body	NN
cord-261566-fn08b0y2	82	17	.	.	.
cord-261566-fn08b0y2	83	1	The	the	DT
cord-261566-fn08b0y2	83	2	mucosal	mucosal	JJ
cord-261566-fn08b0y2	83	3	immune	immune	JJ
cord-261566-fn08b0y2	83	4	system	system	NN
cord-261566-fn08b0y2	83	5	consists	consist	VBZ
cord-261566-fn08b0y2	83	6	of	of	IN
cord-261566-fn08b0y2	83	7	a	a	DT
cord-261566-fn08b0y2	83	8	complex	complex	JJ
cord-261566-fn08b0y2	83	9	network	network	NN
cord-261566-fn08b0y2	83	10	of	of	IN
cord-261566-fn08b0y2	83	11	tissues	tissue	NNS
cord-261566-fn08b0y2	83	12	,	,	,
cord-261566-fn08b0y2	83	13	non	non	JJ
cord-261566-fn08b0y2	83	14	-	-	JJ
cord-261566-fn08b0y2	83	15	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	83	16	/lymphoid	/lymphoid	.
cord-261566-fn08b0y2	83	17	cells	cell	NNS
cord-261566-fn08b0y2	83	18	,	,	,
cord-261566-fn08b0y2	83	19	and	and	CC
cord-261566-fn08b0y2	83	20	effector	effector	NN
cord-261566-fn08b0y2	83	21	molecules	molecule	NNS
cord-261566-fn08b0y2	83	22	including	include	VBG
cord-261566-fn08b0y2	83	23	cytokines	cytokine	NNS
cord-261566-fn08b0y2	83	24	,	,	,
cord-261566-fn08b0y2	83	25	chemokines	chemokine	NNS
cord-261566-fn08b0y2	83	26	,	,	,
cord-261566-fn08b0y2	83	27	and	and	CC
cord-261566-fn08b0y2	83	28	antibodies	antibody	NNS
cord-261566-fn08b0y2	83	29	.	.	.
cord-261566-fn08b0y2	84	1	36	36	CD
cord-261566-fn08b0y2	85	1	The	the	DT
cord-261566-fn08b0y2	85	2	mucosal	mucosal	JJ
cord-261566-fn08b0y2	85	3	immune	immune	JJ
cord-261566-fn08b0y2	85	4	system	system	NN
cord-261566-fn08b0y2	85	5	is	be	VBZ
cord-261566-fn08b0y2	85	6	compartmentalized	compartmentalize	VBN
cord-261566-fn08b0y2	85	7	into	into	IN
cord-261566-fn08b0y2	85	8	immune	immune	JJ
cord-261566-fn08b0y2	85	9	inductive	inductive	JJ
cord-261566-fn08b0y2	85	10	sites	site	NNS
cord-261566-fn08b0y2	85	11	-	-	:
cord-261566-fn08b0y2	85	12	where	where	WRB
cord-261566-fn08b0y2	85	13	antigen	antigen	NN
cord-261566-fn08b0y2	85	14	sampling	sampling	NN
cord-261566-fn08b0y2	85	15	from	from	IN
cord-261566-fn08b0y2	85	16	mucosal	mucosal	JJ
cord-261566-fn08b0y2	85	17	surface	surface	NN
cord-261566-fn08b0y2	85	18	occurs	occur	VBZ
cord-261566-fn08b0y2	85	19	and	and	CC
cord-261566-fn08b0y2	85	20	then	then	RB
cord-261566-fn08b0y2	85	21	priming	prime	VBG
cord-261566-fn08b0y2	85	22	of	of	IN
cord-261566-fn08b0y2	85	23	B	b	NN
cord-261566-fn08b0y2	85	24	cells	cell	NNS
cord-261566-fn08b0y2	85	25	and	and	CC
cord-261566-fn08b0y2	85	26	T	t	NN
cord-261566-fn08b0y2	85	27	cells	cell	NNS
cord-261566-fn08b0y2	85	28	takes	take	VBZ
cord-261566-fn08b0y2	85	29	place	place	NN
cord-261566-fn08b0y2	85	30	,	,	,
cord-261566-fn08b0y2	85	31	and	and	CC
cord-261566-fn08b0y2	85	32	immune	immune	JJ
cord-261566-fn08b0y2	85	33	effector	effector	NN
cord-261566-fn08b0y2	85	34	site	site	NN
cord-261566-fn08b0y2	85	35	-	-	:
cord-261566-fn08b0y2	85	36	where	where	WRB
cord-261566-fn08b0y2	85	37	the	the	DT
cord-261566-fn08b0y2	85	38	activated	activate	VBN
cord-261566-fn08b0y2	85	39	immune	immune	JJ
cord-261566-fn08b0y2	85	40	effector	effector	NN
cord-261566-fn08b0y2	85	41	cells	cell	NNS
cord-261566-fn08b0y2	85	42	move	move	VBP
cord-261566-fn08b0y2	85	43	after	after	IN
cord-261566-fn08b0y2	85	44	extravasation	extravasation	NN
cord-261566-fn08b0y2	85	45	and	and	CC
cord-261566-fn08b0y2	85	46	secrete	secrete	JJ
cord-261566-fn08b0y2	85	47	cytokines	cytokine	NNS
cord-261566-fn08b0y2	85	48	to	to	TO
cord-261566-fn08b0y2	85	49	promote	promote	VB
cord-261566-fn08b0y2	85	50	IgA	IgA	NNP
cord-261566-fn08b0y2	85	51	class	class	NN
cord-261566-fn08b0y2	85	52	-	-	HYPH
cord-261566-fn08b0y2	85	53	switch	switch	NN
cord-261566-fn08b0y2	85	54	recombination	recombination	NN
cord-261566-fn08b0y2	85	55	.	.	.
cord-261566-fn08b0y2	86	1	37	37	CD
cord-261566-fn08b0y2	86	2	,	,	,
cord-261566-fn08b0y2	86	3	38	38	CD
cord-261566-fn08b0y2	86	4	Inductive	Inductive	NNP
cord-261566-fn08b0y2	86	5	site	site	NN
cord-261566-fn08b0y2	86	6	for	for	IN
cord-261566-fn08b0y2	86	7	the	the	DT
cord-261566-fn08b0y2	86	8	mucosal	mucosal	JJ
cord-261566-fn08b0y2	86	9	immune	immune	JJ
cord-261566-fn08b0y2	86	10	system	system	NN
cord-261566-fn08b0y2	86	11	is	be	VBZ
cord-261566-fn08b0y2	86	12	constituted	constitute	VBN
cord-261566-fn08b0y2	86	13	by	by	IN
cord-261566-fn08b0y2	86	14	mucosa	mucosa	NN
cord-261566-fn08b0y2	86	15	-	-	HYPH
cord-261566-fn08b0y2	86	16	associated	associate	VBN
cord-261566-fn08b0y2	86	17	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	86	18	tissue	tissue	NN
cord-261566-fn08b0y2	86	19	(	(	-LRB-
cord-261566-fn08b0y2	86	20	MALT	malt	NN
cord-261566-fn08b0y2	86	21	)	)	-RRB-
cord-261566-fn08b0y2	86	22	.	.	.
cord-261566-fn08b0y2	87	1	MALT	malt	NN
cord-261566-fn08b0y2	87	2	comprises	comprise	VBZ
cord-261566-fn08b0y2	87	3	of	of	IN
cord-261566-fn08b0y2	87	4	highly	highly	RB
cord-261566-fn08b0y2	87	5	organized	organize	VBN
cord-261566-fn08b0y2	87	6	structures	structure	NNS
cord-261566-fn08b0y2	87	7	such	such	JJ
cord-261566-fn08b0y2	87	8	as	as	IN
cord-261566-fn08b0y2	87	9	appendix	appendix	NN
cord-261566-fn08b0y2	87	10	and	and	CC
cord-261566-fn08b0y2	87	11	Peyer	Peyer	NNP
cord-261566-fn08b0y2	87	12	's	's	POS
cord-261566-fn08b0y2	87	13	patches	patch	NNS
cord-261566-fn08b0y2	87	14	in	in	IN
cord-261566-fn08b0y2	87	15	the	the	DT
cord-261566-fn08b0y2	87	16	intestine	intestine	NN
cord-261566-fn08b0y2	87	17	and	and	CC
cord-261566-fn08b0y2	87	18	tonsils	tonsil	NNS
cord-261566-fn08b0y2	87	19	in	in	IN
cord-261566-fn08b0y2	87	20	the	the	DT
cord-261566-fn08b0y2	87	21	upper	upper	JJ
cord-261566-fn08b0y2	87	22	airway	airway	NN
cord-261566-fn08b0y2	87	23	.	.	.
cord-261566-fn08b0y2	88	1	The	the	DT
cord-261566-fn08b0y2	88	2	effector	effector	NN
cord-261566-fn08b0y2	88	3	sites	site	NNS
cord-261566-fn08b0y2	88	4	of	of	IN
cord-261566-fn08b0y2	88	5	the	the	DT
cord-261566-fn08b0y2	88	6	mucosal	mucosal	JJ
cord-261566-fn08b0y2	88	7	immune	immune	JJ
cord-261566-fn08b0y2	88	8	system	system	NN
cord-261566-fn08b0y2	88	9	include	include	VBP
cord-261566-fn08b0y2	88	10	lamina	lamina	JJ
cord-261566-fn08b0y2	88	11	propria	propria	NN
cord-261566-fn08b0y2	88	12	of	of	IN
cord-261566-fn08b0y2	88	13	various	various	JJ
cord-261566-fn08b0y2	88	14	mucosae	mucosae	NN
cord-261566-fn08b0y2	88	15	,	,	,
cord-261566-fn08b0y2	88	16	surface	surface	NN
cord-261566-fn08b0y2	88	17	epithelia	epithelium	NNS
cord-261566-fn08b0y2	88	18	,	,	,
cord-261566-fn08b0y2	88	19	and	and	CC
cord-261566-fn08b0y2	88	20	exocrine	exocrine	JJ
cord-261566-fn08b0y2	88	21	glands	gland	NNS
cord-261566-fn08b0y2	88	22	.	.	.
cord-261566-fn08b0y2	89	1	Gut	gut	NN
cord-261566-fn08b0y2	89	2	-	-	HYPH
cord-261566-fn08b0y2	89	3	associated	associate	VBN
cord-261566-fn08b0y2	89	4	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	89	5	tissue	tissue	NN
cord-261566-fn08b0y2	89	6	(	(	-LRB-
cord-261566-fn08b0y2	89	7	GALT	GALT	NNP
cord-261566-fn08b0y2	89	8	)	)	-RRB-
cord-261566-fn08b0y2	89	9	and	and	CC
cord-261566-fn08b0y2	89	10	nasopharyngeal	nasopharyngeal	JJ
cord-261566-fn08b0y2	89	11	-	-	HYPH
cord-261566-fn08b0y2	89	12	associated	associate	VBN
cord-261566-fn08b0y2	89	13	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	89	14	tissue	tissue	NN
cord-261566-fn08b0y2	89	15	(	(	-LRB-
cord-261566-fn08b0y2	89	16	NALT	NALT	NNP
cord-261566-fn08b0y2	89	17	)	)	-RRB-
cord-261566-fn08b0y2	89	18	represent	represent	VBP
cord-261566-fn08b0y2	89	19	the	the	DT
cord-261566-fn08b0y2	89	20	major	major	JJ
cord-261566-fn08b0y2	89	21	mucosal	mucosal	JJ
cord-261566-fn08b0y2	89	22	inductive	inductive	JJ
cord-261566-fn08b0y2	89	23	sites	site	NNS
cord-261566-fn08b0y2	89	24	.	.	.
cord-261566-fn08b0y2	90	1	Waldeyer	Waldeyer	NNP
cord-261566-fn08b0y2	90	2	's	's	POS
cord-261566-fn08b0y2	90	3	ring	ring	NN
cord-261566-fn08b0y2	90	4	and	and	CC
cord-261566-fn08b0y2	90	5	oropharyngeal	oropharyngeal	JJ
cord-261566-fn08b0y2	90	6	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	90	7	tissues	tissue	NNS
cord-261566-fn08b0y2	90	8	(	(	-LRB-
cord-261566-fn08b0y2	90	9	paired	pair	VBD
cord-261566-fn08b0y2	90	10	palatine	palatine	NNP
cord-261566-fn08b0y2	90	11	tonsils	tonsil	NNS
cord-261566-fn08b0y2	90	12	)	)	-RRB-
cord-261566-fn08b0y2	90	13	in	in	IN
cord-261566-fn08b0y2	90	14	humans	human	NNS
cord-261566-fn08b0y2	90	15	are	be	VBP
cord-261566-fn08b0y2	90	16	considered	consider	VBN
cord-261566-fn08b0y2	90	17	anatomical	anatomical	JJ
cord-261566-fn08b0y2	90	18	equivalent	equivalent	NN
cord-261566-fn08b0y2	90	19	of	of	IN
cord-261566-fn08b0y2	90	20	murine	murine	JJ
cord-261566-fn08b0y2	90	21	NALT	NALT	NNP
cord-261566-fn08b0y2	90	22	.	.	.
cord-261566-fn08b0y2	91	1	39	39	CD
cord-261566-fn08b0y2	91	2	Larynx	larynx	NN
cord-261566-fn08b0y2	91	3	-	-	HYPH
cord-261566-fn08b0y2	91	4	associated	associate	VBN
cord-261566-fn08b0y2	91	5	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	91	6	tissue	tissue	NN
cord-261566-fn08b0y2	91	7	(	(	-LRB-
cord-261566-fn08b0y2	91	8	LALT	LALT	NNP
cord-261566-fn08b0y2	91	9	)	)	-RRB-
cord-261566-fn08b0y2	91	10	,	,	,
cord-261566-fn08b0y2	91	11	salivary	salivary	JJ
cord-261566-fn08b0y2	91	12	duct	duct	NN
cord-261566-fn08b0y2	91	13	-	-	HYPH
cord-261566-fn08b0y2	91	14	associated	associate	VBN
cord-261566-fn08b0y2	91	15	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	91	16	tissue	tissue	NN
cord-261566-fn08b0y2	91	17	(	(	-LRB-
cord-261566-fn08b0y2	91	18	SDALT	SDALT	NNP
cord-261566-fn08b0y2	91	19	)	)	-RRB-
cord-261566-fn08b0y2	91	20	,	,	,
cord-261566-fn08b0y2	91	21	lacrimal	lacrimal	JJ
cord-261566-fn08b0y2	91	22	ductassociated	ductassociated	JJ
cord-261566-fn08b0y2	91	23	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	91	24	tissue	tissue	NN
cord-261566-fn08b0y2	91	25	(	(	-LRB-
cord-261566-fn08b0y2	91	26	LDALT	LDALT	NNP
cord-261566-fn08b0y2	91	27	)	)	-RRB-
cord-261566-fn08b0y2	91	28	,	,	,
cord-261566-fn08b0y2	91	29	and	and	CC
cord-261566-fn08b0y2	91	30	conjunctiva	conjunctiva	NN
cord-261566-fn08b0y2	91	31	-	-	HYPH
cord-261566-fn08b0y2	91	32	associated	associate	VBN
cord-261566-fn08b0y2	91	33	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	91	34	tissue	tissue	NN
cord-261566-fn08b0y2	91	35	(	(	-LRB-
cord-261566-fn08b0y2	91	36	CALT	CALT	NNP
cord-261566-fn08b0y2	91	37	)	)	-RRB-
cord-261566-fn08b0y2	91	38	are	be	VBP
cord-261566-fn08b0y2	91	39	also	also	RB
cord-261566-fn08b0y2	91	40	considered	consider	VBN
cord-261566-fn08b0y2	91	41	part	part	NN
cord-261566-fn08b0y2	91	42	of	of	IN
cord-261566-fn08b0y2	91	43	human	human	JJ
cord-261566-fn08b0y2	91	44	MALT	malt	NN
cord-261566-fn08b0y2	91	45	.	.	.
cord-261566-fn08b0y2	92	1	40	40	CD
cord-261566-fn08b0y2	93	1	These	these	DT
cord-261566-fn08b0y2	93	2	mucosal	mucosal	JJ
cord-261566-fn08b0y2	93	3	inductive	inductive	JJ
cord-261566-fn08b0y2	93	4	sites	site	NNS
cord-261566-fn08b0y2	93	5	are	be	VBP
cord-261566-fn08b0y2	93	6	covered	cover	VBN
cord-261566-fn08b0y2	93	7	with	with	IN
cord-261566-fn08b0y2	93	8	a	a	DT
cord-261566-fn08b0y2	93	9	layer	layer	NN
cord-261566-fn08b0y2	93	10	of	of	IN
cord-261566-fn08b0y2	93	11	enterocytes	enterocyte	NNS
cord-261566-fn08b0y2	93	12	and	and	CC
cord-261566-fn08b0y2	93	13	microfold	microfold	JJ
cord-261566-fn08b0y2	93	14	cells	cell	NNS
cord-261566-fn08b0y2	93	15	(	(	-LRB-
cord-261566-fn08b0y2	93	16	M	M	NNP
cord-261566-fn08b0y2	93	17	cells	cell	NNS
cord-261566-fn08b0y2	93	18	)	)	-RRB-
cord-261566-fn08b0y2	93	19	.	.	.
cord-261566-fn08b0y2	94	1	M	M	NNP
cord-261566-fn08b0y2	94	2	cells	cell	NNS
cord-261566-fn08b0y2	94	3	are	be	VBP
cord-261566-fn08b0y2	94	4	specialized	specialize	VBN
cord-261566-fn08b0y2	94	5	thin	thin	JJ
cord-261566-fn08b0y2	94	6	epithelial	epithelial	JJ
cord-261566-fn08b0y2	94	7	cells	cell	NNS
cord-261566-fn08b0y2	94	8	that	that	WDT
cord-261566-fn08b0y2	94	9	move	move	VBP
cord-261566-fn08b0y2	94	10	soluble	soluble	JJ
cord-261566-fn08b0y2	94	11	antigen	antigen	NN
cord-261566-fn08b0y2	94	12	from	from	IN
cord-261566-fn08b0y2	94	13	the	the	DT
cord-261566-fn08b0y2	94	14	gut	gut	NN
cord-261566-fn08b0y2	94	15	lumen	lumen	NN
cord-261566-fn08b0y2	94	16	to	to	IN
cord-261566-fn08b0y2	94	17	the	the	DT
cord-261566-fn08b0y2	94	18	underlying	underlying	JJ
cord-261566-fn08b0y2	94	19	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	94	20	tissues	tissue	NNS
cord-261566-fn08b0y2	94	21	via	via	IN
cord-261566-fn08b0y2	94	22	transcytosis	transcytosis	NNP
cord-261566-fn08b0y2	94	23	.	.	.
cord-261566-fn08b0y2	95	1	Exogenous	exogenous	JJ
cord-261566-fn08b0y2	95	2	antigens	antigen	NNS
cord-261566-fn08b0y2	95	3	can	can	MD
cord-261566-fn08b0y2	95	4	activate	activate	VB
cord-261566-fn08b0y2	95	5	T	T	NNP
cord-261566-fn08b0y2	95	6	cells	cell	NNS
cord-261566-fn08b0y2	95	7	directly	directly	RB
cord-261566-fn08b0y2	95	8	or	or	CC
cord-261566-fn08b0y2	95	9	are	be	VBP
cord-261566-fn08b0y2	95	10	handed	hand	VBN
cord-261566-fn08b0y2	95	11	off	off	RP
cord-261566-fn08b0y2	95	12	to	to	IN
cord-261566-fn08b0y2	95	13	dendritic	dendritic	JJ
cord-261566-fn08b0y2	95	14	cells	cell	NNS
cord-261566-fn08b0y2	95	15	(	(	-LRB-
cord-261566-fn08b0y2	95	16	DCs	DCs	NNP
cord-261566-fn08b0y2	95	17	)	)	-RRB-
cord-261566-fn08b0y2	95	18	that	that	WDT
cord-261566-fn08b0y2	95	19	can	can	MD
cord-261566-fn08b0y2	95	20	act	act	VB
cord-261566-fn08b0y2	95	21	as	as	IN
cord-261566-fn08b0y2	95	22	antigen	antigen	NN
cord-261566-fn08b0y2	95	23	-	-	HYPH
cord-261566-fn08b0y2	95	24	presenting	present	VBG
cord-261566-fn08b0y2	95	25	cells	cell	NNS
cord-261566-fn08b0y2	95	26	(	(	-LRB-
cord-261566-fn08b0y2	95	27	APCs	apc	NNS
cord-261566-fn08b0y2	95	28	)	)	-RRB-
cord-261566-fn08b0y2	95	29	.	.	.
cord-261566-fn08b0y2	96	1	41	41	CD
cord-261566-fn08b0y2	96	2	,	,	,
cord-261566-fn08b0y2	96	3	42	42	CD
cord-261566-fn08b0y2	97	1	These	these	DT
cord-261566-fn08b0y2	97	2	primed	prime	VBN
cord-261566-fn08b0y2	97	3	T	t	NN
cord-261566-fn08b0y2	97	4	cells	cell	NNS
cord-261566-fn08b0y2	97	5	move	move	VBP
cord-261566-fn08b0y2	97	6	to	to	IN
cord-261566-fn08b0y2	97	7	the	the	DT
cord-261566-fn08b0y2	97	8	germinal	germinal	JJ
cord-261566-fn08b0y2	97	9	centers	center	NNS
cord-261566-fn08b0y2	97	10	and	and	CC
cord-261566-fn08b0y2	97	11	secrete	secrete	JJ
cord-261566-fn08b0y2	97	12	cytokines	cytokine	NNS
cord-261566-fn08b0y2	97	13	to	to	TO
cord-261566-fn08b0y2	97	14	promote	promote	VB
cord-261566-fn08b0y2	97	15	B	b	NN
cord-261566-fn08b0y2	97	16	-	-	HYPH
cord-261566-fn08b0y2	97	17	cell	cell	NN
cord-261566-fn08b0y2	97	18	isotype	isotype	NN
cord-261566-fn08b0y2	97	19	switching	switch	VBG
cord-261566-fn08b0y2	97	20	to	to	IN
cord-261566-fn08b0y2	97	21	IgA	IgA	NNP
cord-261566-fn08b0y2	97	22	production	production	NN
cord-261566-fn08b0y2	97	23	.	.	.
cord-261566-fn08b0y2	98	1	43	43	CD
cord-261566-fn08b0y2	98	2	Secretory	secretory	JJ
cord-261566-fn08b0y2	98	3	IgA	iga	NN
cord-261566-fn08b0y2	98	4	(	(	-LRB-
cord-261566-fn08b0y2	98	5	sIgA	sIgA	NNS
cord-261566-fn08b0y2	98	6	)	)	-RRB-
cord-261566-fn08b0y2	98	7	antibodies	antibody	NNS
cord-261566-fn08b0y2	98	8	are	be	VBP
cord-261566-fn08b0y2	98	9	the	the	DT
cord-261566-fn08b0y2	98	10	most	most	RBS
cord-261566-fn08b0y2	98	11	essential	essential	JJ
cord-261566-fn08b0y2	98	12	effector	effector	NN
cord-261566-fn08b0y2	98	13	molecule	molecule	NN
cord-261566-fn08b0y2	98	14	in	in	IN
cord-261566-fn08b0y2	98	15	the	the	DT
cord-261566-fn08b0y2	98	16	mucosa	mucosa	NN
cord-261566-fn08b0y2	98	17	.	.	.
cord-261566-fn08b0y2	99	1	It	-PRON-	PRP
cord-261566-fn08b0y2	99	2	is	be	VBZ
cord-261566-fn08b0y2	99	3	recognized	recognize	VBN
cord-261566-fn08b0y2	99	4	as	as	IN
cord-261566-fn08b0y2	99	5	the	the	DT
cord-261566-fn08b0y2	99	6	first	first	JJ
cord-261566-fn08b0y2	99	7	line	line	NN
cord-261566-fn08b0y2	99	8	of	of	IN
cord-261566-fn08b0y2	99	9	protection	protection	NN
cord-261566-fn08b0y2	99	10	against	against	IN
cord-261566-fn08b0y2	99	11	foreign	foreign	JJ
cord-261566-fn08b0y2	99	12	toxins	toxin	NNS
cord-261566-fn08b0y2	99	13	,	,	,
cord-261566-fn08b0y2	99	14	pathogens	pathogen	NNS
cord-261566-fn08b0y2	99	15	,	,	,
cord-261566-fn08b0y2	99	16	and	and	CC
cord-261566-fn08b0y2	99	17	overgrowth	overgrowth	NN
cord-261566-fn08b0y2	99	18	of	of	IN
cord-261566-fn08b0y2	99	19	commensal	commensal	JJ
cord-261566-fn08b0y2	99	20	microbes	microbe	NNS
cord-261566-fn08b0y2	99	21	.	.	.
cord-261566-fn08b0y2	100	1	It	-PRON-	PRP
cord-261566-fn08b0y2	100	2	is	be	VBZ
cord-261566-fn08b0y2	100	3	secreted	secrete	VBN
cord-261566-fn08b0y2	100	4	as	as	IN
cord-261566-fn08b0y2	100	5	a	a	DT
cord-261566-fn08b0y2	100	6	dimer	dimer	NN
cord-261566-fn08b0y2	100	7	joined	join	VBN
cord-261566-fn08b0y2	100	8	together	together	RB
cord-261566-fn08b0y2	100	9	by	by	IN
cord-261566-fn08b0y2	100	10	a	a	DT
cord-261566-fn08b0y2	100	11	joining	join	VBG
cord-261566-fn08b0y2	100	12	chain	chain	NN
cord-261566-fn08b0y2	100	13	and	and	CC
cord-261566-fn08b0y2	100	14	is	be	VBZ
cord-261566-fn08b0y2	100	15	actively	actively	RB
cord-261566-fn08b0y2	100	16	transported	transport	VBN
cord-261566-fn08b0y2	100	17	exclusively	exclusively	RB
cord-261566-fn08b0y2	100	18	across	across	IN
cord-261566-fn08b0y2	100	19	the	the	DT
cord-261566-fn08b0y2	100	20	mucosal	mucosal	JJ
cord-261566-fn08b0y2	100	21	surface	surface	NN
cord-261566-fn08b0y2	100	22	via	via	IN
cord-261566-fn08b0y2	100	23	a	a	DT
cord-261566-fn08b0y2	100	24	polymeric	polymeric	JJ
cord-261566-fn08b0y2	100	25	IgA	IgA	NNP
cord-261566-fn08b0y2	100	26	receptor	receptor	NN
cord-261566-fn08b0y2	100	27	.	.	.
cord-261566-fn08b0y2	101	1	44	44	CD
cord-261566-fn08b0y2	102	1	The	the	DT
cord-261566-fn08b0y2	102	2	activated	activate	VBN
cord-261566-fn08b0y2	102	3	T	t	NN
cord-261566-fn08b0y2	102	4	and	and	CC
cord-261566-fn08b0y2	102	5	B	b	NN
cord-261566-fn08b0y2	102	6	cells	cell	NNS
cord-261566-fn08b0y2	102	7	retain	retain	VBP
cord-261566-fn08b0y2	102	8	immunological	immunological	JJ
cord-261566-fn08b0y2	102	9	memory	memory	NN
cord-261566-fn08b0y2	102	10	and	and	CC
cord-261566-fn08b0y2	102	11	contribute	contribute	VB
cord-261566-fn08b0y2	102	12	to	to	IN
cord-261566-fn08b0y2	102	13	long	long	RB
cord-261566-fn08b0y2	102	14	-	-	HYPH
cord-261566-fn08b0y2	102	15	lasting	last	VBG
cord-261566-fn08b0y2	102	16	protective	protective	JJ
cord-261566-fn08b0y2	102	17	immunity	immunity	NN
cord-261566-fn08b0y2	102	18	against	against	IN
cord-261566-fn08b0y2	102	19	the	the	DT
cord-261566-fn08b0y2	102	20	pathogen	pathogen	NN
cord-261566-fn08b0y2	102	21	in	in	IN
cord-261566-fn08b0y2	102	22	systemic	systemic	JJ
cord-261566-fn08b0y2	102	23	and	and	CC
cord-261566-fn08b0y2	102	24	mucosal	mucosal	JJ
cord-261566-fn08b0y2	102	25	systems	system	NNS
cord-261566-fn08b0y2	102	26	.	.	.
cord-261566-fn08b0y2	103	1	sIgA	sIgA	NNS
cord-261566-fn08b0y2	103	2	neutralizes	neutralize	VBZ
cord-261566-fn08b0y2	103	3	toxins	toxin	NNS
cord-261566-fn08b0y2	103	4	or	or	CC
cord-261566-fn08b0y2	103	5	pathogens	pathogen	NNS
cord-261566-fn08b0y2	103	6	in	in	IN
cord-261566-fn08b0y2	103	7	the	the	DT
cord-261566-fn08b0y2	103	8	mucosal	mucosal	JJ
cord-261566-fn08b0y2	103	9	environment	environment	NN
cord-261566-fn08b0y2	103	10	using	use	VBG
cord-261566-fn08b0y2	103	11	three	three	CD
cord-261566-fn08b0y2	103	12	mechanisms	mechanism	NNS
cord-261566-fn08b0y2	103	13	:	:	:
cord-261566-fn08b0y2	103	14	immune	immune	JJ
cord-261566-fn08b0y2	103	15	exclusion	exclusion	NN
cord-261566-fn08b0y2	103	16	,	,	,
cord-261566-fn08b0y2	103	17	antigen	antigen	NN
cord-261566-fn08b0y2	103	18	excretion	excretion	NN
cord-261566-fn08b0y2	103	19	,	,	,
cord-261566-fn08b0y2	103	20	and	and	CC
cord-261566-fn08b0y2	103	21	intracellular	intracellular	JJ
cord-261566-fn08b0y2	103	22	neutralization	neutralization	NN
cord-261566-fn08b0y2	104	1	(	(	-LRB-
cord-261566-fn08b0y2	104	2	Figure	figure	NN
cord-261566-fn08b0y2	104	3	1	1	CD
cord-261566-fn08b0y2	104	4	)	)	-RRB-
cord-261566-fn08b0y2	104	5	.	.	.
cord-261566-fn08b0y2	105	1	45	45	CD
cord-261566-fn08b0y2	106	1	In	in	IN
cord-261566-fn08b0y2	106	2	addition	addition	NN
cord-261566-fn08b0y2	106	3	to	to	IN
cord-261566-fn08b0y2	106	4	sIgA	siga	CD
cord-261566-fn08b0y2	106	5	,	,	,
cord-261566-fn08b0y2	106	6	transudated	transudated	NNP
cord-261566-fn08b0y2	106	7	IgA	IgA	NNP
cord-261566-fn08b0y2	106	8	and	and	CC
cord-261566-fn08b0y2	106	9	IgG	IgG	NNP
cord-261566-fn08b0y2	106	10	,	,	,
cord-261566-fn08b0y2	106	11	which	which	WDT
cord-261566-fn08b0y2	106	12	are	be	VBP
cord-261566-fn08b0y2	106	13	generated	generate	VBN
cord-261566-fn08b0y2	106	14	in	in	IN
cord-261566-fn08b0y2	106	15	response	response	NN
cord-261566-fn08b0y2	106	16	to	to	IN
cord-261566-fn08b0y2	106	17	both	both	CC
cord-261566-fn08b0y2	106	18	systemic	systemic	JJ
cord-261566-fn08b0y2	106	19	and	and	CC
cord-261566-fn08b0y2	106	20	mucosal	mucosal	JJ
cord-261566-fn08b0y2	106	21	vaccination	vaccination	NN
cord-261566-fn08b0y2	106	22	,	,	,
cord-261566-fn08b0y2	106	23	also	also	RB
cord-261566-fn08b0y2	106	24	contribute	contribute	VB
cord-261566-fn08b0y2	106	25	to	to	IN
cord-261566-fn08b0y2	106	26	local	local	JJ
cord-261566-fn08b0y2	106	27	surface	surface	NN
cord-261566-fn08b0y2	106	28	defense	defense	NN
cord-261566-fn08b0y2	106	29	in	in	IN
cord-261566-fn08b0y2	106	30	the	the	DT
cord-261566-fn08b0y2	106	31	genitourinary	genitourinary	JJ
cord-261566-fn08b0y2	106	32	mucosa	mucosa	NN
cord-261566-fn08b0y2	106	33	and	and	CC
cord-261566-fn08b0y2	106	34	in	in	IN
cord-261566-fn08b0y2	106	35	the	the	DT
cord-261566-fn08b0y2	106	36	lower	low	JJR
cord-261566-fn08b0y2	106	37	respiratory	respiratory	JJ
cord-261566-fn08b0y2	106	38	tract	tract	NN
cord-261566-fn08b0y2	106	39	which	which	WDT
cord-261566-fn08b0y2	106	40	are	be	VBP
cord-261566-fn08b0y2	106	41	more	more	RBR
cord-261566-fn08b0y2	106	42	permeable	permeable	JJ
cord-261566-fn08b0y2	106	43	to	to	IN
cord-261566-fn08b0y2	106	44	serum	serum	NN
cord-261566-fn08b0y2	106	45	-	-	HYPH
cord-261566-fn08b0y2	106	46	derived	derive	VBN
cord-261566-fn08b0y2	106	47	antibodies	antibody	NNS
cord-261566-fn08b0y2	106	48	than	than	IN
cord-261566-fn08b0y2	106	49	intestine	intestine	NN
cord-261566-fn08b0y2	106	50	.	.	.
cord-261566-fn08b0y2	107	1	These	these	DT
cord-261566-fn08b0y2	107	2	antibodies	antibody	NNS
cord-261566-fn08b0y2	107	3	employ	employ	VBP
cord-261566-fn08b0y2	107	4	a	a	DT
cord-261566-fn08b0y2	107	5	diverse	diverse	JJ
cord-261566-fn08b0y2	107	6	range	range	NN
cord-261566-fn08b0y2	107	7	of	of	IN
cord-261566-fn08b0y2	107	8	effector	effector	NN
cord-261566-fn08b0y2	107	9	functions	function	NNS
cord-261566-fn08b0y2	107	10	to	to	TO
cord-261566-fn08b0y2	107	11	protect	protect	VB
cord-261566-fn08b0y2	107	12	against	against	IN
cord-261566-fn08b0y2	107	13	pathogens	pathogen	NNS
cord-261566-fn08b0y2	107	14	.	.	.
cord-261566-fn08b0y2	108	1	They	-PRON-	PRP
cord-261566-fn08b0y2	108	2	neutralize	neutralize	VBP
cord-261566-fn08b0y2	108	3	toxins	toxin	NNS
cord-261566-fn08b0y2	108	4	;	;	:
cord-261566-fn08b0y2	108	5	can	can	MD
cord-261566-fn08b0y2	108	6	mediate	mediate	VB
cord-261566-fn08b0y2	108	7	opsonization	opsonization	NN
cord-261566-fn08b0y2	108	8	and	and	CC
cord-261566-fn08b0y2	108	9	facilitate	facilitate	VB
cord-261566-fn08b0y2	108	10	internalization	internalization	NN
cord-261566-fn08b0y2	108	11	of	of	IN
cord-261566-fn08b0y2	108	12	invading	invade	VBG
cord-261566-fn08b0y2	108	13	pathogens	pathogen	NNS
cord-261566-fn08b0y2	108	14	by	by	IN
cord-261566-fn08b0y2	108	15	phagocytes	phagocyte	NNS
cord-261566-fn08b0y2	108	16	.	.	.
cord-261566-fn08b0y2	109	1	Transudated	Transudated	NNP
cord-261566-fn08b0y2	109	2	IgG	igg	NN
cord-261566-fn08b0y2	109	3	exert	exert	VBP
cord-261566-fn08b0y2	109	4	its	-PRON-	PRP$
cord-261566-fn08b0y2	109	5	immunopathological	immunopathological	JJ
cord-261566-fn08b0y2	109	6	effect	effect	NN
cord-261566-fn08b0y2	109	7	when	when	WRB
cord-261566-fn08b0y2	109	8	sIgA	siga	NN
cord-261566-fn08b0y2	109	9	-	-	HYPH
cord-261566-fn08b0y2	109	10	dependent	dependent	JJ
cord-261566-fn08b0y2	109	11	elimination	elimination	NN
cord-261566-fn08b0y2	109	12	of	of	IN
cord-261566-fn08b0y2	109	13	pathogen	pathogen	NN
cord-261566-fn08b0y2	109	14	is	be	VBZ
cord-261566-fn08b0y2	109	15	unsuccessful	unsuccessful	JJ
cord-261566-fn08b0y2	109	16	.	.	.
cord-261566-fn08b0y2	110	1	46	46	CD
cord-261566-fn08b0y2	110	2	Serum	serum	NN
cord-261566-fn08b0y2	110	3	IgG	igg	NN
cord-261566-fn08b0y2	110	4	antibodies	antibody	NNS
cord-261566-fn08b0y2	110	5	protect	protect	VBP
cord-261566-fn08b0y2	110	6	against	against	IN
cord-261566-fn08b0y2	110	7	viremia	viremia	NN
cord-261566-fn08b0y2	110	8	and	and	CC
cord-261566-fn08b0y2	110	9	are	be	VBP
cord-261566-fn08b0y2	110	10	crucial	crucial	JJ
cord-261566-fn08b0y2	110	11	for	for	IN
cord-261566-fn08b0y2	110	12	virus	virus	NN
cord-261566-fn08b0y2	110	13	clearance	clearance	NN
cord-261566-fn08b0y2	110	14	from	from	IN
cord-261566-fn08b0y2	110	15	systemic	systemic	JJ
cord-261566-fn08b0y2	110	16	circulation	circulation	NN
cord-261566-fn08b0y2	110	17	.	.	.
cord-261566-fn08b0y2	111	1	A	a	DT
cord-261566-fn08b0y2	111	2	mucosal	mucosal	JJ
cord-261566-fn08b0y2	111	3	vaccine	vaccine	NN
cord-261566-fn08b0y2	111	4	can	can	MD
cord-261566-fn08b0y2	111	5	be	be	VB
cord-261566-fn08b0y2	111	6	developed	develop	VBN
cord-261566-fn08b0y2	111	7	based	base	VBN
cord-261566-fn08b0y2	111	8	on	on	IN
cord-261566-fn08b0y2	111	9	one	one	CD
cord-261566-fn08b0y2	111	10	of	of	IN
cord-261566-fn08b0y2	111	11	the	the	DT
cord-261566-fn08b0y2	111	12	several	several	JJ
cord-261566-fn08b0y2	111	13	vaccine	vaccine	NN
cord-261566-fn08b0y2	111	14	platforms	platform	NNS
cord-261566-fn08b0y2	111	15	including	include	VBG
cord-261566-fn08b0y2	111	16	viral	viral	JJ
cord-261566-fn08b0y2	111	17	vectors	vector	NNS
cord-261566-fn08b0y2	111	18	,	,	,
cord-261566-fn08b0y2	111	19	virus	virus	NN
cord-261566-fn08b0y2	111	20	-	-	HYPH
cord-261566-fn08b0y2	111	21	like	like	JJ
cord-261566-fn08b0y2	111	22	particle	particle	NN
cord-261566-fn08b0y2	111	23	(	(	-LRB-
cord-261566-fn08b0y2	111	24	VLP)-based	vlp)-based	JJ
cord-261566-fn08b0y2	111	25	,	,	,
cord-261566-fn08b0y2	111	26	DNAs	dna	NNS
cord-261566-fn08b0y2	111	27	,	,	,
cord-261566-fn08b0y2	111	28	subunit	subunit	NN
cord-261566-fn08b0y2	111	29	,	,	,
cord-261566-fn08b0y2	111	30	inactivated	inactivate	VBN
cord-261566-fn08b0y2	111	31	whole	whole	JJ
cord-261566-fn08b0y2	111	32	virus	virus	NN
cord-261566-fn08b0y2	111	33	,	,	,
cord-261566-fn08b0y2	111	34	or	or	CC
cord-261566-fn08b0y2	111	35	live	live	RB
cord-261566-fn08b0y2	111	36	-	-	HYPH
cord-261566-fn08b0y2	111	37	attenuated	attenuated	JJ
cord-261566-fn08b0y2	111	38	vaccine	vaccine	NN
cord-261566-fn08b0y2	111	39	.	.	.
cord-261566-fn08b0y2	112	1	6	6	CD
cord-261566-fn08b0y2	112	2	,	,	,
cord-261566-fn08b0y2	112	3	47	47	CD
cord-261566-fn08b0y2	112	4	,	,	,
cord-261566-fn08b0y2	112	5	48	48	CD
cord-261566-fn08b0y2	113	1	Each	each	DT
cord-261566-fn08b0y2	113	2	of	of	IN
cord-261566-fn08b0y2	113	3	these	these	DT
cord-261566-fn08b0y2	113	4	platforms	platform	NNS
cord-261566-fn08b0y2	113	5	has	have	VBZ
cord-261566-fn08b0y2	113	6	its	-PRON-	PRP$
cord-261566-fn08b0y2	113	7	own	own	JJ
cord-261566-fn08b0y2	113	8	advantages	advantage	NNS
cord-261566-fn08b0y2	113	9	and	and	CC
cord-261566-fn08b0y2	113	10	disadvantages	disadvantage	NNS
cord-261566-fn08b0y2	113	11	.	.	.
cord-261566-fn08b0y2	114	1	VLP	VLP	NNP
cord-261566-fn08b0y2	114	2	-	-	HYPH
cord-261566-fn08b0y2	114	3	based	base	VBN
cord-261566-fn08b0y2	114	4	vaccines	vaccine	NNS
cord-261566-fn08b0y2	114	5	are	be	VBP
cord-261566-fn08b0y2	114	6	composed	compose	VBN
cord-261566-fn08b0y2	114	7	of	of	IN
cord-261566-fn08b0y2	114	8	viral	viral	JJ
cord-261566-fn08b0y2	114	9	structural	structural	JJ
cord-261566-fn08b0y2	114	10	proteins	protein	NNS
cord-261566-fn08b0y2	114	11	capable	capable	JJ
cord-261566-fn08b0y2	114	12	of	of	IN
cord-261566-fn08b0y2	114	13	selfassembly	selfassembly	NNP
cord-261566-fn08b0y2	114	14	.	.	.
cord-261566-fn08b0y2	115	1	DNA	DNA	NNP
cord-261566-fn08b0y2	115	2	vaccine	vaccine	NN
cord-261566-fn08b0y2	115	3	comprises	comprise	VBZ
cord-261566-fn08b0y2	115	4	viral	viral	JJ
cord-261566-fn08b0y2	115	5	immunogens	immunogen	NNS
cord-261566-fn08b0y2	115	6	encoded	encode	VBN
cord-261566-fn08b0y2	115	7	by	by	IN
cord-261566-fn08b0y2	115	8	a	a	DT
cord-261566-fn08b0y2	115	9	recombinant	recombinant	JJ
cord-261566-fn08b0y2	115	10	plasmid	plasmid	NN
cord-261566-fn08b0y2	115	11	that	that	WDT
cord-261566-fn08b0y2	115	12	is	be	VBZ
cord-261566-fn08b0y2	115	13	delivered	deliver	VBN
cord-261566-fn08b0y2	115	14	to	to	IN
cord-261566-fn08b0y2	115	15	the	the	DT
cord-261566-fn08b0y2	115	16	site	site	NN
cord-261566-fn08b0y2	115	17	of	of	IN
cord-261566-fn08b0y2	115	18	administration	administration	NN
cord-261566-fn08b0y2	115	19	where	where	WRB
cord-261566-fn08b0y2	115	20	the	the	DT
cord-261566-fn08b0y2	115	21	plasmid	plasmid	NN
cord-261566-fn08b0y2	115	22	expresses	express	VBZ
cord-261566-fn08b0y2	115	23	itself	-PRON-	PRP
cord-261566-fn08b0y2	115	24	and	and	CC
cord-261566-fn08b0y2	115	25	elicits	elicit	VBZ
cord-261566-fn08b0y2	115	26	the	the	DT
cord-261566-fn08b0y2	115	27	desired	desire	VBN
cord-261566-fn08b0y2	115	28	immune	immune	JJ
cord-261566-fn08b0y2	115	29	response	response	NN
cord-261566-fn08b0y2	115	30	.	.	.
cord-261566-fn08b0y2	116	1	49	49	CD
cord-261566-fn08b0y2	117	1	Both	both	CC
cord-261566-fn08b0y2	117	2	these	these	DT
cord-261566-fn08b0y2	117	3	safe	safe	JJ
cord-261566-fn08b0y2	117	4	vaccine	vaccine	NN
cord-261566-fn08b0y2	117	5	platforms	platform	NNS
cord-261566-fn08b0y2	117	6	preserve	preserve	VBP
cord-261566-fn08b0y2	117	7	the	the	DT
cord-261566-fn08b0y2	117	8	inherent	inherent	JJ
cord-261566-fn08b0y2	117	9	antigenic	antigenic	JJ
cord-261566-fn08b0y2	117	10	structure	structure	NN
cord-261566-fn08b0y2	117	11	of	of	IN
cord-261566-fn08b0y2	117	12	viral	viral	JJ
cord-261566-fn08b0y2	117	13	immunogens	immunogen	NNS
cord-261566-fn08b0y2	117	14	and	and	CC
cord-261566-fn08b0y2	117	15	are	be	VBP
cord-261566-fn08b0y2	117	16	noninfectious	noninfectious	JJ
cord-261566-fn08b0y2	117	17	but	but	CC
cord-261566-fn08b0y2	117	18	often	often	RB
cord-261566-fn08b0y2	117	19	suffer	suffer	VBP
cord-261566-fn08b0y2	117	20	from	from	IN
cord-261566-fn08b0y2	117	21	weak	weak	JJ
cord-261566-fn08b0y2	117	22	immunogenicity	immunogenicity	NN
cord-261566-fn08b0y2	117	23	.	.	.
cord-261566-fn08b0y2	118	1	Viral	viral	JJ
cord-261566-fn08b0y2	118	2	vectors	vector	NNS
cord-261566-fn08b0y2	118	3	encode	encode	VBP
cord-261566-fn08b0y2	118	4	the	the	DT
cord-261566-fn08b0y2	118	5	antigenic	antigenic	JJ
cord-261566-fn08b0y2	118	6	protein	protein	NN
cord-261566-fn08b0y2	118	7	and	and	CC
cord-261566-fn08b0y2	118	8	are	be	VBP
cord-261566-fn08b0y2	118	9	delivered	deliver	VBN
cord-261566-fn08b0y2	118	10	to	to	IN
cord-261566-fn08b0y2	118	11	the	the	DT
cord-261566-fn08b0y2	118	12	host	host	NN
cord-261566-fn08b0y2	118	13	cell	cell	NN
cord-261566-fn08b0y2	118	14	where	where	WRB
cord-261566-fn08b0y2	118	15	the	the	DT
cord-261566-fn08b0y2	118	16	antigen	antigen	NN
cord-261566-fn08b0y2	118	17	is	be	VBZ
cord-261566-fn08b0y2	118	18	expressed	express	VBN
cord-261566-fn08b0y2	118	19	and	and	CC
cord-261566-fn08b0y2	118	20	is	be	VBZ
cord-261566-fn08b0y2	118	21	presented	present	VBN
cord-261566-fn08b0y2	118	22	on	on	IN
cord-261566-fn08b0y2	118	23	the	the	DT
cord-261566-fn08b0y2	118	24	surface	surface	NN
cord-261566-fn08b0y2	118	25	of	of	IN
cord-261566-fn08b0y2	118	26	APCs	apc	NNS
cord-261566-fn08b0y2	118	27	to	to	TO
cord-261566-fn08b0y2	118	28	induce	induce	VB
cord-261566-fn08b0y2	118	29	a	a	DT
cord-261566-fn08b0y2	118	30	cellular	cellular	JJ
cord-261566-fn08b0y2	118	31	and	and	CC
cord-261566-fn08b0y2	118	32	humoral	humoral	JJ
cord-261566-fn08b0y2	118	33	immune	immune	JJ
cord-261566-fn08b0y2	118	34	response	response	NN
cord-261566-fn08b0y2	118	35	.	.	.
cord-261566-fn08b0y2	119	1	50	50	CD
cord-261566-fn08b0y2	120	1	These	these	DT
cord-261566-fn08b0y2	120	2	vaccines	vaccine	NNS
cord-261566-fn08b0y2	120	3	are	be	VBP
cord-261566-fn08b0y2	120	4	highly	highly	RB
cord-261566-fn08b0y2	120	5	efficient	efficient	JJ
cord-261566-fn08b0y2	120	6	but	but	CC
cord-261566-fn08b0y2	120	7	preexisting	preexisting	JJ
cord-261566-fn08b0y2	120	8	immunity	immunity	NN
cord-261566-fn08b0y2	120	9	against	against	IN
cord-261566-fn08b0y2	120	10	the	the	DT
cord-261566-fn08b0y2	120	11	viral	viral	JJ
cord-261566-fn08b0y2	120	12	vector	vector	NN
cord-261566-fn08b0y2	120	13	might	may	MD
cord-261566-fn08b0y2	120	14	cause	cause	VB
cord-261566-fn08b0y2	120	15	a	a	DT
cord-261566-fn08b0y2	120	16	harmful	harmful	JJ
cord-261566-fn08b0y2	120	17	immune	immune	JJ
cord-261566-fn08b0y2	120	18	response	response	NN
cord-261566-fn08b0y2	120	19	in	in	IN
cord-261566-fn08b0y2	120	20	some	some	DT
cord-261566-fn08b0y2	120	21	recipients	recipient	NNS
cord-261566-fn08b0y2	120	22	.	.	.
cord-261566-fn08b0y2	121	1	Live	live	VB
cord-261566-fn08b0y2	121	2	-	-	HYPH
cord-261566-fn08b0y2	121	3	attenuated	attenuate	VBN
cord-261566-fn08b0y2	121	4	vaccines	vaccine	NNS
cord-261566-fn08b0y2	121	5	or	or	CC
cord-261566-fn08b0y2	121	6	inactivated	inactivate	VBN
cord-261566-fn08b0y2	121	7	vaccines	vaccine	NNS
cord-261566-fn08b0y2	121	8	are	be	VBP
cord-261566-fn08b0y2	121	9	based	base	VBN
cord-261566-fn08b0y2	121	10	on	on	IN
cord-261566-fn08b0y2	121	11	pathogens	pathogen	NNS
cord-261566-fn08b0y2	121	12	that	that	WDT
cord-261566-fn08b0y2	121	13	have	have	VBP
cord-261566-fn08b0y2	121	14	been	be	VBN
cord-261566-fn08b0y2	121	15	attenuated	attenuate	VBN
cord-261566-fn08b0y2	121	16	or	or	CC
cord-261566-fn08b0y2	121	17	inactivated	inactivate	VBN
cord-261566-fn08b0y2	121	18	by	by	IN
cord-261566-fn08b0y2	121	19	heat	heat	NN
cord-261566-fn08b0y2	121	20	or	or	CC
cord-261566-fn08b0y2	121	21	chemical	chemical	NN
cord-261566-fn08b0y2	121	22	treatment	treatment	NN
cord-261566-fn08b0y2	121	23	.	.	.
cord-261566-fn08b0y2	122	1	46	46	CD
cord-261566-fn08b0y2	123	1	As	as	IN
cord-261566-fn08b0y2	123	2	of	of	IN
cord-261566-fn08b0y2	123	3	now	now	RB
cord-261566-fn08b0y2	123	4	,	,	,
cord-261566-fn08b0y2	123	5	all	all	PDT
cord-261566-fn08b0y2	123	6	the	the	DT
cord-261566-fn08b0y2	123	7	mucosal	mucosal	JJ
cord-261566-fn08b0y2	123	8	vaccines	vaccine	NNS
cord-261566-fn08b0y2	123	9	licensed	license	VBN
cord-261566-fn08b0y2	123	10	for	for	IN
cord-261566-fn08b0y2	123	11	human	human	JJ
cord-261566-fn08b0y2	123	12	use	use	NN
cord-261566-fn08b0y2	123	13	are	be	VBP
cord-261566-fn08b0y2	123	14	based	base	VBN
cord-261566-fn08b0y2	123	15	on	on	IN
cord-261566-fn08b0y2	123	16	liveattenuated	liveattenuated	JJ
cord-261566-fn08b0y2	123	17	approach	approach	NN
cord-261566-fn08b0y2	123	18	including	include	VBG
cord-261566-fn08b0y2	123	19	oral	oral	JJ
cord-261566-fn08b0y2	123	20	polio	polio	NN
cord-261566-fn08b0y2	123	21	vaccine	vaccine	NN
cord-261566-fn08b0y2	123	22	(	(	-LRB-
cord-261566-fn08b0y2	123	23	OPV	OPV	NNP
cord-261566-fn08b0y2	123	24	)	)	-RRB-
cord-261566-fn08b0y2	123	25	and	and	CC
cord-261566-fn08b0y2	123	26	intranasal	intranasal	NN
cord-261566-fn08b0y2	123	27	influenza	influenza	NN
cord-261566-fn08b0y2	123	28	vaccine	vaccine	NN
cord-261566-fn08b0y2	123	29	(	(	-LRB-
cord-261566-fn08b0y2	124	1	FluMist	FluMist	NNP
cord-261566-fn08b0y2	124	2	®	®	VBP
cord-261566-fn08b0y2	124	3	)	)	-RRB-
cord-261566-fn08b0y2	124	4	.	.	.
cord-261566-fn08b0y2	125	1	Safety	safety	NN
cord-261566-fn08b0y2	125	2	concerns	concern	NNS
cord-261566-fn08b0y2	125	3	are	be	VBP
cord-261566-fn08b0y2	125	4	often	often	RB
cord-261566-fn08b0y2	125	5	associated	associate	VBN
cord-261566-fn08b0y2	125	6	with	with	IN
cord-261566-fn08b0y2	125	7	attenuated	attenuated	JJ
cord-261566-fn08b0y2	125	8	vaccines	vaccine	NNS
cord-261566-fn08b0y2	125	9	due	due	JJ
cord-261566-fn08b0y2	125	10	to	to	IN
cord-261566-fn08b0y2	125	11	the	the	DT
cord-261566-fn08b0y2	125	12	possibility	possibility	NN
cord-261566-fn08b0y2	125	13	of	of	IN
cord-261566-fn08b0y2	125	14	incomplete	incomplete	JJ
cord-261566-fn08b0y2	125	15	inactivation	inactivation	NN
cord-261566-fn08b0y2	125	16	of	of	IN
cord-261566-fn08b0y2	125	17	harmful	harmful	JJ
cord-261566-fn08b0y2	125	18	pathogens	pathogen	NNS
cord-261566-fn08b0y2	125	19	.	.	.
cord-261566-fn08b0y2	126	1	Subunit	subunit	NN
cord-261566-fn08b0y2	126	2	vaccines	vaccine	NNS
cord-261566-fn08b0y2	126	3	consist	consist	VBP
cord-261566-fn08b0y2	126	4	of	of	IN
cord-261566-fn08b0y2	126	5	specific	specific	JJ
cord-261566-fn08b0y2	126	6	antigenic	antigenic	JJ
cord-261566-fn08b0y2	126	7	fragments	fragment	NNS
cord-261566-fn08b0y2	126	8	of	of	IN
cord-261566-fn08b0y2	126	9	virus	virus	NN
cord-261566-fn08b0y2	126	10	capable	capable	JJ
cord-261566-fn08b0y2	126	11	of	of	IN
cord-261566-fn08b0y2	126	12	eliciting	elicit	VBG
cord-261566-fn08b0y2	126	13	strong	strong	JJ
cord-261566-fn08b0y2	126	14	antibody	antibody	NN
cord-261566-fn08b0y2	126	15	-	-	HYPH
cord-261566-fn08b0y2	126	16	mediated	mediate	VBN
cord-261566-fn08b0y2	126	17	and	and	CC
cord-261566-fn08b0y2	126	18	cellular	cellular	JJ
cord-261566-fn08b0y2	126	19	immune	immune	JJ
cord-261566-fn08b0y2	126	20	response	response	NN
cord-261566-fn08b0y2	126	21	.	.	.
cord-261566-fn08b0y2	127	1	51	51	CD
cord-261566-fn08b0y2	128	1	Inactivated	inactivate	VBN
cord-261566-fn08b0y2	128	2	whole	whole	JJ
cord-261566-fn08b0y2	128	3	virus	virus	NN
cord-261566-fn08b0y2	128	4	vaccines	vaccine	NNS
cord-261566-fn08b0y2	128	5	and	and	CC
cord-261566-fn08b0y2	128	6	subunit	subunit	NN
cord-261566-fn08b0y2	128	7	vaccines	vaccine	NNS
cord-261566-fn08b0y2	128	8	are	be	VBP
cord-261566-fn08b0y2	128	9	relatively	relatively	RB
cord-261566-fn08b0y2	128	10	inexpensive	inexpensive	JJ
cord-261566-fn08b0y2	128	11	,	,	,
cord-261566-fn08b0y2	128	12	inert	inert	JJ
cord-261566-fn08b0y2	128	13	,	,	,
cord-261566-fn08b0y2	128	14	and	and	CC
cord-261566-fn08b0y2	128	15	nontoxic	nontoxic	JJ
cord-261566-fn08b0y2	129	1	but	but	CC
cord-261566-fn08b0y2	129	2	the	the	DT
cord-261566-fn08b0y2	129	3	possibility	possibility	NN
cord-261566-fn08b0y2	129	4	of	of	IN
cord-261566-fn08b0y2	129	5	alteration	alteration	NN
cord-261566-fn08b0y2	129	6	of	of	IN
cord-261566-fn08b0y2	129	7	immunogenicity	immunogenicity	NN
cord-261566-fn08b0y2	129	8	of	of	IN
cord-261566-fn08b0y2	129	9	antigens	antigen	NNS
cord-261566-fn08b0y2	129	10	needs	need	NNS
cord-261566-fn08b0y2	129	11	to	to	TO
cord-261566-fn08b0y2	129	12	be	be	VB
cord-261566-fn08b0y2	129	13	confirmed	confirm	VBN
cord-261566-fn08b0y2	129	14	consistently	consistently	RB
cord-261566-fn08b0y2	129	15	.	.	.
cord-261566-fn08b0y2	130	1	Few	few	JJ
cord-261566-fn08b0y2	130	2	SARS	SARS	NNP
cord-261566-fn08b0y2	130	3	-	-	HYPH
cord-261566-fn08b0y2	130	4	CoV	CoV	NNP
cord-261566-fn08b0y2	130	5	and	and	CC
cord-261566-fn08b0y2	130	6	MERS	MERS	NNP
cord-261566-fn08b0y2	130	7	-	-	HYPH
cord-261566-fn08b0y2	130	8	CoV	CoV	NNP
cord-261566-fn08b0y2	130	9	vaccines	vaccine	NNS
cord-261566-fn08b0y2	130	10	based	base	VBN
cord-261566-fn08b0y2	130	11	on	on	IN
cord-261566-fn08b0y2	130	12	the	the	DT
cord-261566-fn08b0y2	130	13	different	different	JJ
cord-261566-fn08b0y2	130	14	platforms	platform	NNS
cord-261566-fn08b0y2	130	15	are	be	VBP
cord-261566-fn08b0y2	130	16	summarized	summarize	VBN
cord-261566-fn08b0y2	130	17	in	in	IN
cord-261566-fn08b0y2	130	18	Table	Table	NNP
cord-261566-fn08b0y2	130	19	1	1	CD
cord-261566-fn08b0y2	130	20	.	.	.
cord-261566-fn08b0y2	131	1	S	s	NN
cord-261566-fn08b0y2	131	2	protein	protein	NN
cord-261566-fn08b0y2	131	3	is	be	VBZ
cord-261566-fn08b0y2	131	4	the	the	DT
cord-261566-fn08b0y2	131	5	main	main	JJ
cord-261566-fn08b0y2	131	6	antigenic	antigenic	JJ
cord-261566-fn08b0y2	131	7	component	component	NN
cord-261566-fn08b0y2	131	8	of	of	IN
cord-261566-fn08b0y2	131	9	SARS	SARS	NNP
cord-261566-fn08b0y2	131	10	-	-	HYPH
cord-261566-fn08b0y2	131	11	CoV	CoV	NNP
cord-261566-fn08b0y2	131	12	,	,	,
cord-261566-fn08b0y2	131	13	SARS	SARS	NNP
cord-261566-fn08b0y2	131	14	-	-	HYPH
cord-261566-fn08b0y2	131	15	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	131	16	,	,	,
cord-261566-fn08b0y2	131	17	and	and	CC
cord-261566-fn08b0y2	131	18	MERS	MERS	NNP
cord-261566-fn08b0y2	131	19	-	-	HYPH
cord-261566-fn08b0y2	131	20	CoV	CoV	NNP
cord-261566-fn08b0y2	131	21	among	among	IN
cord-261566-fn08b0y2	131	22	four	four	CD
cord-261566-fn08b0y2	131	23	structural	structural	JJ
cord-261566-fn08b0y2	131	24	proteins	protein	NNS
cord-261566-fn08b0y2	131	25	(	(	-LRB-
cord-261566-fn08b0y2	131	26	S	S	NNP
cord-261566-fn08b0y2	131	27	,	,	,
cord-261566-fn08b0y2	131	28	E	E	NNP
cord-261566-fn08b0y2	131	29	,	,	,
cord-261566-fn08b0y2	131	30	M	M	NNP
cord-261566-fn08b0y2	131	31	,	,	,
cord-261566-fn08b0y2	131	32	and	and	CC
cord-261566-fn08b0y2	131	33	N	n	CD
cord-261566-fn08b0y2	131	34	proteins	protein	NNS
cord-261566-fn08b0y2	131	35	)	)	-RRB-
cord-261566-fn08b0y2	131	36	.	.	.
cord-261566-fn08b0y2	132	1	Vaccines	vaccine	NNS
cord-261566-fn08b0y2	132	2	using	use	VBG
cord-261566-fn08b0y2	132	3	S	S	NNP
cord-261566-fn08b0y2	132	4	protein	protein	NN
cord-261566-fn08b0y2	132	5	elicit	elicit	VB
cord-261566-fn08b0y2	132	6	a	a	DT
cord-261566-fn08b0y2	132	7	potent	potent	JJ
cord-261566-fn08b0y2	132	8	immune	immune	JJ
cord-261566-fn08b0y2	132	9	response	response	NN
cord-261566-fn08b0y2	132	10	and	and	CC
cord-261566-fn08b0y2	132	11	inhibit	inhibit	VB
cord-261566-fn08b0y2	132	12	viral	viral	JJ
cord-261566-fn08b0y2	132	13	infection	infection	NN
cord-261566-fn08b0y2	132	14	.	.	.
cord-261566-fn08b0y2	133	1	9	9	CD
cord-261566-fn08b0y2	133	2	,	,	,
cord-261566-fn08b0y2	133	3	53	53	CD
cord-261566-fn08b0y2	133	4	,	,	,
cord-261566-fn08b0y2	133	5	64	64	CD
cord-261566-fn08b0y2	134	1	But	but	CC
cord-261566-fn08b0y2	134	2	the	the	DT
cord-261566-fn08b0y2	134	3	use	use	NN
cord-261566-fn08b0y2	134	4	of	of	IN
cord-261566-fn08b0y2	134	5	fulllength	fulllength	NN
cord-261566-fn08b0y2	134	6	S	s	NN
cord-261566-fn08b0y2	134	7	protein	protein	NN
cord-261566-fn08b0y2	134	8	as	as	IN
cord-261566-fn08b0y2	134	9	an	an	DT
cord-261566-fn08b0y2	134	10	antigen	antigen	NN
cord-261566-fn08b0y2	134	11	for	for	IN
cord-261566-fn08b0y2	134	12	vaccine	vaccine	NN
cord-261566-fn08b0y2	134	13	design	design	NN
cord-261566-fn08b0y2	134	14	has	have	VBZ
cord-261566-fn08b0y2	134	15	raised	raise	VBN
cord-261566-fn08b0y2	134	16	few	few	JJ
cord-261566-fn08b0y2	134	17	safety	safety	NN
cord-261566-fn08b0y2	134	18	issues	issue	NNS
cord-261566-fn08b0y2	134	19	due	due	JJ
cord-261566-fn08b0y2	134	20	to	to	IN
cord-261566-fn08b0y2	134	21	ADE	ADE	NNP
cord-261566-fn08b0y2	134	22	of	of	IN
cord-261566-fn08b0y2	134	23	viral	viral	JJ
cord-261566-fn08b0y2	134	24	infection	infection	NN
cord-261566-fn08b0y2	134	25	in	in	IN
cord-261566-fn08b0y2	134	26	vaccinated	vaccinated	JJ
cord-261566-fn08b0y2	134	27	subjects	subject	NNS
cord-261566-fn08b0y2	134	28	.	.	.
cord-261566-fn08b0y2	135	1	A	a	DT
cord-261566-fn08b0y2	135	2	study	study	NN
cord-261566-fn08b0y2	135	3	on	on	IN
cord-261566-fn08b0y2	135	4	the	the	DT
cord-261566-fn08b0y2	135	5	Chinese	chinese	JJ
cord-261566-fn08b0y2	135	6	macaque	macaque	NN
cord-261566-fn08b0y2	135	7	models	model	NNS
cord-261566-fn08b0y2	135	8	for	for	IN
cord-261566-fn08b0y2	135	9	SARS	SARS	NNP
cord-261566-fn08b0y2	135	10	-	-	HYPH
cord-261566-fn08b0y2	135	11	CoV	CoV	NNP
cord-261566-fn08b0y2	135	12	showed	show	VBD
cord-261566-fn08b0y2	135	13	greater	great	JJR
cord-261566-fn08b0y2	135	14	lung	lung	NN
cord-261566-fn08b0y2	135	15	damage	damage	NN
cord-261566-fn08b0y2	135	16	in	in	IN
cord-261566-fn08b0y2	135	17	vaccinated	vaccinate	VBN
cord-261566-fn08b0y2	135	18	animals	animal	NNS
cord-261566-fn08b0y2	135	19	(	(	-LRB-
cord-261566-fn08b0y2	135	20	vaccinated	vaccinate	VBN
cord-261566-fn08b0y2	135	21	with	with	IN
cord-261566-fn08b0y2	135	22	fulllength	fulllength	NN
cord-261566-fn08b0y2	135	23	S	s	NN
cord-261566-fn08b0y2	135	24	proteins	protein	NNS
cord-261566-fn08b0y2	135	25	)	)	-RRB-
cord-261566-fn08b0y2	135	26	relative	relative	JJ
cord-261566-fn08b0y2	135	27	to	to	IN
cord-261566-fn08b0y2	135	28	unvaccinated	unvaccinated	JJ
cord-261566-fn08b0y2	135	29	subjects	subject	NNS
cord-261566-fn08b0y2	135	30	upon	upon	IN
cord-261566-fn08b0y2	135	31	virus	virus	NN
cord-261566-fn08b0y2	135	32	challenge	challenge	NN
cord-261566-fn08b0y2	135	33	.	.	.
cord-261566-fn08b0y2	136	1	65	65	CD
cord-261566-fn08b0y2	137	1	Anti	Anti	NNP
cord-261566-fn08b0y2	137	2	-	-	NNP
cord-261566-fn08b0y2	137	3	S	S	NNP
cord-261566-fn08b0y2	137	4	protein	protein	NN
cord-261566-fn08b0y2	137	5	IgG	igg	NN
cord-261566-fn08b0y2	137	6	antibodies	antibody	NNS
cord-261566-fn08b0y2	137	7	have	have	VBP
cord-261566-fn08b0y2	137	8	been	be	VBN
cord-261566-fn08b0y2	137	9	implicated	implicate	VBN
cord-261566-fn08b0y2	137	10	in	in	IN
cord-261566-fn08b0y2	137	11	this	this	DT
cord-261566-fn08b0y2	137	12	acute	acute	JJ
cord-261566-fn08b0y2	137	13	alveolar	alveolar	JJ
cord-261566-fn08b0y2	137	14	damage	damage	NN
cord-261566-fn08b0y2	137	15	on	on	IN
cord-261566-fn08b0y2	137	16	exposure	exposure	NN
cord-261566-fn08b0y2	137	17	to	to	IN
cord-261566-fn08b0y2	137	18	the	the	DT
cord-261566-fn08b0y2	137	19	virus	virus	NN
cord-261566-fn08b0y2	137	20	.	.	.
cord-261566-fn08b0y2	138	1	Similar	similar	JJ
cord-261566-fn08b0y2	138	2	symptoms	symptom	NNS
cord-261566-fn08b0y2	138	3	have	have	VBP
cord-261566-fn08b0y2	138	4	been	be	VBN
cord-261566-fn08b0y2	138	5	observed	observe	VBN
cord-261566-fn08b0y2	138	6	in	in	IN
cord-261566-fn08b0y2	138	7	critical	critical	JJ
cord-261566-fn08b0y2	138	8	patients	patient	NNS
cord-261566-fn08b0y2	138	9	with	with	IN
cord-261566-fn08b0y2	138	10	SARS	SARS	NNP
cord-261566-fn08b0y2	138	11	-	-	HYPH
cord-261566-fn08b0y2	138	12	CoV	CoV	NNP
cord-261566-fn08b0y2	138	13	infection	infection	NN
cord-261566-fn08b0y2	138	14	.	.	.
cord-261566-fn08b0y2	139	1	66	66	CD
cord-261566-fn08b0y2	140	1	It	-PRON-	PRP
cord-261566-fn08b0y2	140	2	is	be	VBZ
cord-261566-fn08b0y2	140	3	speculated	speculate	VBN
cord-261566-fn08b0y2	140	4	that	that	IN
cord-261566-fn08b0y2	140	5	ADE	ADE	NNP
cord-261566-fn08b0y2	140	6	of	of	IN
cord-261566-fn08b0y2	140	7	viral	viral	JJ
cord-261566-fn08b0y2	140	8	infection	infection	NN
cord-261566-fn08b0y2	140	9	is	be	VBZ
cord-261566-fn08b0y2	140	10	mediated	mediate	VBN
cord-261566-fn08b0y2	140	11	through	through	IN
cord-261566-fn08b0y2	140	12	the	the	DT
cord-261566-fn08b0y2	140	13	binding	binding	NN
cord-261566-fn08b0y2	140	14	of	of	IN
cord-261566-fn08b0y2	140	15	virus	virus	NN
cord-261566-fn08b0y2	140	16	-	-	HYPH
cord-261566-fn08b0y2	140	17	neutralizing	neutralize	VBG
cord-261566-fn08b0y2	140	18	antibody	antibody	NN
cord-261566-fn08b0y2	140	19	complex	complex	NN
cord-261566-fn08b0y2	140	20	to	to	IN
cord-261566-fn08b0y2	140	21	the	the	DT
cord-261566-fn08b0y2	140	22	Fc	Fc	NNP
cord-261566-fn08b0y2	140	23	receptors	receptor	NNS
cord-261566-fn08b0y2	140	24	on	on	IN
cord-261566-fn08b0y2	140	25	the	the	DT
cord-261566-fn08b0y2	140	26	monocytes	monocyte	NNS
cord-261566-fn08b0y2	140	27	/	/	SYM
cord-261566-fn08b0y2	140	28	macrophages	macrophage	NNS
cord-261566-fn08b0y2	140	29	leading	lead	VBG
cord-261566-fn08b0y2	140	30	to	to	IN
cord-261566-fn08b0y2	140	31	increased	increase	VBN
cord-261566-fn08b0y2	140	32	production	production	NN
cord-261566-fn08b0y2	140	33	of	of	IN
cord-261566-fn08b0y2	140	34	pro	pro	JJ
cord-261566-fn08b0y2	140	35	-	-	JJ
cord-261566-fn08b0y2	140	36	inflammatory	inflammatory	JJ
cord-261566-fn08b0y2	140	37	cytokines	cytokine	NNS
cord-261566-fn08b0y2	140	38	.	.	.
cord-261566-fn08b0y2	141	1	Additionally	additionally	RB
cord-261566-fn08b0y2	141	2	,	,	,
cord-261566-fn08b0y2	141	3	this	this	DT
cord-261566-fn08b0y2	141	4	virus	virus	NN
cord-261566-fn08b0y2	141	5	-	-	HYPH
cord-261566-fn08b0y2	141	6	antibody	antibody	NN
cord-261566-fn08b0y2	141	7	complex	complex	NN
cord-261566-fn08b0y2	141	8	might	may	MD
cord-261566-fn08b0y2	141	9	activate	activate	VB
cord-261566-fn08b0y2	141	10	the	the	DT
cord-261566-fn08b0y2	141	11	classical	classical	JJ
cord-261566-fn08b0y2	141	12	pathway	pathway	NN
cord-261566-fn08b0y2	141	13	of	of	IN
cord-261566-fn08b0y2	141	14	complement	complement	JJ
cord-261566-fn08b0y2	141	15	system	system	NN
cord-261566-fn08b0y2	141	16	or	or	CC
cord-261566-fn08b0y2	141	17	antibody	antibody	NN
cord-261566-fn08b0y2	141	18	-	-	HYPH
cord-261566-fn08b0y2	141	19	mediated	mediate	VBN
cord-261566-fn08b0y2	141	20	cytotoxicity	cytotoxicity	NN
cord-261566-fn08b0y2	141	21	leading	lead	VBG
cord-261566-fn08b0y2	141	22	to	to	IN
cord-261566-fn08b0y2	141	23	cellular	cellular	JJ
cord-261566-fn08b0y2	141	24	damage	damage	NN
cord-261566-fn08b0y2	141	25	.	.	.
cord-261566-fn08b0y2	142	1	67	67	CD
cord-261566-fn08b0y2	143	1	Taking	take	VBG
cord-261566-fn08b0y2	143	2	a	a	DT
cord-261566-fn08b0y2	143	3	cue	cue	NN
cord-261566-fn08b0y2	143	4	from	from	IN
cord-261566-fn08b0y2	143	5	studies	study	NNS
cord-261566-fn08b0y2	143	6	with	with	IN
cord-261566-fn08b0y2	143	7	SARS	SARS	NNP
cord-261566-fn08b0y2	143	8	-	-	HYPH
cord-261566-fn08b0y2	143	9	CoV	CoV	NNP
cord-261566-fn08b0y2	143	10	and	and	CC
cord-261566-fn08b0y2	143	11	MERS	MERS	NNP
cord-261566-fn08b0y2	143	12	-	-	HYPH
cord-261566-fn08b0y2	143	13	CoV	CoV	NNP
cord-261566-fn08b0y2	143	14	,	,	,
cord-261566-fn08b0y2	143	15	caution	caution	NN
cord-261566-fn08b0y2	143	16	must	must	MD
cord-261566-fn08b0y2	143	17	be	be	VB
cord-261566-fn08b0y2	143	18	exercised	exercise	VBN
cord-261566-fn08b0y2	143	19	in	in	IN
cord-261566-fn08b0y2	143	20	selecting	select	VBG
cord-261566-fn08b0y2	143	21	an	an	DT
cord-261566-fn08b0y2	143	22	antigen	antigen	NN
cord-261566-fn08b0y2	143	23	target	target	NN
cord-261566-fn08b0y2	143	24	that	that	WDT
cord-261566-fn08b0y2	143	25	minimize	minimize	VBP
cord-261566-fn08b0y2	143	26	ADE	ade	NN
cord-261566-fn08b0y2	143	27	while	while	IN
cord-261566-fn08b0y2	143	28	inducing	induce	VBG
cord-261566-fn08b0y2	143	29	a	a	DT
cord-261566-fn08b0y2	143	30	potent	potent	JJ
cord-261566-fn08b0y2	143	31	immune	immune	JJ
cord-261566-fn08b0y2	143	32	response	response	NN
cord-261566-fn08b0y2	143	33	against	against	IN
cord-261566-fn08b0y2	143	34	future	future	JJ
cord-261566-fn08b0y2	143	35	exposure	exposure	NN
cord-261566-fn08b0y2	143	36	to	to	IN
cord-261566-fn08b0y2	143	37	SARS	SARS	NNP
cord-261566-fn08b0y2	143	38	-	-	HYPH
cord-261566-fn08b0y2	143	39	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	143	40	.	.	.
cord-261566-fn08b0y2	144	1	The	the	DT
cord-261566-fn08b0y2	144	2	use	use	NN
cord-261566-fn08b0y2	144	3	of	of	IN
cord-261566-fn08b0y2	144	4	RBD	RBD	NNP
cord-261566-fn08b0y2	144	5	of	of	IN
cord-261566-fn08b0y2	144	6	S	S	NNP
cord-261566-fn08b0y2	144	7	protein	protein	NN
cord-261566-fn08b0y2	144	8	as	as	IN
cord-261566-fn08b0y2	144	9	an	an	DT
cord-261566-fn08b0y2	144	10	antigen	antigen	NN
cord-261566-fn08b0y2	144	11	in	in	IN
cord-261566-fn08b0y2	144	12	the	the	DT
cord-261566-fn08b0y2	144	13	case	case	NN
cord-261566-fn08b0y2	144	14	of	of	IN
cord-261566-fn08b0y2	144	15	SARS	SARS	NNP
cord-261566-fn08b0y2	144	16	-	-	HYPH
cord-261566-fn08b0y2	144	17	CoV	CoV	NNP
cord-261566-fn08b0y2	144	18	or	or	CC
cord-261566-fn08b0y2	144	19	MERS	MERS	NNP
cord-261566-fn08b0y2	144	20	-	-	HYPH
cord-261566-fn08b0y2	144	21	CoV	CoV	NNP
cord-261566-fn08b0y2	144	22	has	have	VBZ
cord-261566-fn08b0y2	144	23	been	be	VBN
cord-261566-fn08b0y2	144	24	extensively	extensively	RB
cord-261566-fn08b0y2	144	25	explored	explore	VBN
cord-261566-fn08b0y2	144	26	.	.	.
cord-261566-fn08b0y2	145	1	9,68	9,68	CD
cord-261566-fn08b0y2	145	2	RBD	RBD	NNP
cord-261566-fn08b0y2	145	3	of	of	IN
cord-261566-fn08b0y2	145	4	S	S	NNP
cord-261566-fn08b0y2	145	5	protein	protein	NN
cord-261566-fn08b0y2	145	6	is	be	VBZ
cord-261566-fn08b0y2	145	7	highly	highly	RB
cord-261566-fn08b0y2	145	8	immunogenic	immunogenic	JJ
cord-261566-fn08b0y2	145	9	and	and	CC
cord-261566-fn08b0y2	145	10	confers	confer	VBZ
cord-261566-fn08b0y2	145	11	neutralizing	neutralize	VBG
cord-261566-fn08b0y2	145	12	capability	capability	NN
cord-261566-fn08b0y2	145	13	against	against	IN
cord-261566-fn08b0y2	145	14	multiple	multiple	JJ
cord-261566-fn08b0y2	145	15	strains	strain	NNS
cord-261566-fn08b0y2	145	16	of	of	IN
cord-261566-fn08b0y2	145	17	SARS	SARS	NNP
cord-261566-fn08b0y2	145	18	-	-	HYPH
cord-261566-fn08b0y2	145	19	CoV	CoV	NNP
cord-261566-fn08b0y2	145	20	and	and	CC
cord-261566-fn08b0y2	145	21	MERS	MERS	NNP
cord-261566-fn08b0y2	145	22	-	-	HYPH
cord-261566-fn08b0y2	145	23	CoV.	CoV.	NNP
cord-261566-fn08b0y2	145	24	RBD	RBD	NNP
cord-261566-fn08b0y2	145	25	-	-	HYPH
cord-261566-fn08b0y2	145	26	based	base	VBN
cord-261566-fn08b0y2	145	27	vaccine	vaccine	NN
cord-261566-fn08b0y2	145	28	minimizes	minimize	VBZ
cord-261566-fn08b0y2	145	29	the	the	DT
cord-261566-fn08b0y2	145	30	risk	risk	NN
cord-261566-fn08b0y2	145	31	of	of	IN
cord-261566-fn08b0y2	145	32	ADE	ADE	NNP
cord-261566-fn08b0y2	145	33	upon	upon	IN
cord-261566-fn08b0y2	145	34	exposure	exposure	NN
cord-261566-fn08b0y2	145	35	to	to	IN
cord-261566-fn08b0y2	145	36	virus	virus	NN
cord-261566-fn08b0y2	145	37	in	in	IN
cord-261566-fn08b0y2	145	38	vaccinated	vaccinated	JJ
cord-261566-fn08b0y2	145	39	individuals	individual	NNS
cord-261566-fn08b0y2	145	40	as	as	IN
cord-261566-fn08b0y2	145	41	it	-PRON-	PRP
cord-261566-fn08b0y2	145	42	lacks	lack	VBZ
cord-261566-fn08b0y2	145	43	the	the	DT
cord-261566-fn08b0y2	145	44	non	non	JJ
cord-261566-fn08b0y2	145	45	-	-	JJ
cord-261566-fn08b0y2	145	46	neutralizing	neutralize	VBG
cord-261566-fn08b0y2	145	47	immunodominant	immunodominant	JJ
cord-261566-fn08b0y2	145	48	region	region	NN
cord-261566-fn08b0y2	145	49	of	of	IN
cord-261566-fn08b0y2	145	50	S	S	NNP
cord-261566-fn08b0y2	145	51	protein	protein	NN
cord-261566-fn08b0y2	145	52	.	.	.
cord-261566-fn08b0y2	146	1	69	69	CD
cord-261566-fn08b0y2	146	2	Other	other	JJ
cord-261566-fn08b0y2	146	3	fragments	fragment	NNS
cord-261566-fn08b0y2	146	4	of	of	IN
cord-261566-fn08b0y2	146	5	S	s	NN
cord-261566-fn08b0y2	146	6	protein	protein	NN
cord-261566-fn08b0y2	146	7	of	of	IN
cord-261566-fn08b0y2	146	8	SARS	SARS	NNP
cord-261566-fn08b0y2	146	9	-	-	HYPH
cord-261566-fn08b0y2	146	10	CoV	CoV	NNP
cord-261566-fn08b0y2	146	11	and	and	CC
cord-261566-fn08b0y2	146	12	MERS	MERS	NNP
cord-261566-fn08b0y2	146	13	-	-	HYPH
cord-261566-fn08b0y2	146	14	CoV	CoV	NNP
cord-261566-fn08b0y2	146	15	that	that	WDT
cord-261566-fn08b0y2	146	16	have	have	VBP
cord-261566-fn08b0y2	146	17	been	be	VBN
cord-261566-fn08b0y2	146	18	used	use	VBN
cord-261566-fn08b0y2	146	19	for	for	IN
cord-261566-fn08b0y2	146	20	vaccine	vaccine	NN
cord-261566-fn08b0y2	146	21	design	design	NN
cord-261566-fn08b0y2	146	22	include	include	VBP
cord-261566-fn08b0y2	146	23	S1	S1	NNP
cord-261566-fn08b0y2	146	24	and	and	CC
cord-261566-fn08b0y2	146	25	S2	s2	NN
cord-261566-fn08b0y2	146	26	fragments	fragment	NNS
cord-261566-fn08b0y2	146	27	(	(	-LRB-
cord-261566-fn08b0y2	146	28	Figure	figure	NN
cord-261566-fn08b0y2	146	29	2	2	CD
cord-261566-fn08b0y2	146	30	)	)	-RRB-
cord-261566-fn08b0y2	146	31	.	.	.
cord-261566-fn08b0y2	147	1	71,72	71,72	CD
cord-261566-fn08b0y2	147	2	A	a	DT
cord-261566-fn08b0y2	147	3	mucosal	mucosal	JJ
cord-261566-fn08b0y2	147	4	vaccine	vaccine	NN
cord-261566-fn08b0y2	147	5	based	base	VBN
cord-261566-fn08b0y2	147	6	on	on	IN
cord-261566-fn08b0y2	147	7	N	n	CD
cord-261566-fn08b0y2	147	8	protein	protein	NN
cord-261566-fn08b0y2	147	9	of	of	IN
cord-261566-fn08b0y2	147	10	SARS	SARS	NNP
cord-261566-fn08b0y2	147	11	-	-	HYPH
cord-261566-fn08b0y2	147	12	CoV	CoV	NNP
cord-261566-fn08b0y2	147	13	has	have	VBZ
cord-261566-fn08b0y2	147	14	shown	show	VBN
cord-261566-fn08b0y2	147	15	the	the	DT
cord-261566-fn08b0y2	147	16	induction	induction	NN
cord-261566-fn08b0y2	147	17	of	of	IN
cord-261566-fn08b0y2	147	18	both	both	CC
cord-261566-fn08b0y2	147	19	cellular	cellular	JJ
cord-261566-fn08b0y2	147	20	and	and	CC
cord-261566-fn08b0y2	147	21	humoral	humoral	JJ
cord-261566-fn08b0y2	147	22	immunity	immunity	NN
cord-261566-fn08b0y2	147	23	in	in	IN
cord-261566-fn08b0y2	147	24	mice	mouse	NNS
cord-261566-fn08b0y2	147	25	.	.	.
cord-261566-fn08b0y2	148	1	61	61	CD
cord-261566-fn08b0y2	148	2	Several	several	JJ
cord-261566-fn08b0y2	148	3	immunogenic	immunogenic	JJ
cord-261566-fn08b0y2	148	4	domains	domain	NNS
cord-261566-fn08b0y2	148	5	of	of	IN
cord-261566-fn08b0y2	148	6	N	n	CD
cord-261566-fn08b0y2	148	7	protein	protein	NN
cord-261566-fn08b0y2	148	8	are	be	VBP
cord-261566-fn08b0y2	148	9	highly	highly	RB
cord-261566-fn08b0y2	148	10	conserved	conserve	VBN
cord-261566-fn08b0y2	148	11	in	in	IN
cord-261566-fn08b0y2	148	12	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	148	13	.	.	.
cord-261566-fn08b0y2	149	1	73	73	CD
cord-261566-fn08b0y2	149	2	N	n	CD
cord-261566-fn08b0y2	149	3	protein	protein	NN
cord-261566-fn08b0y2	149	4	of	of	IN
cord-261566-fn08b0y2	149	5	SARS	SARS	NNP
cord-261566-fn08b0y2	149	6	-	-	HYPH
cord-261566-fn08b0y2	149	7	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	149	8	shares	share	VBZ
cord-261566-fn08b0y2	149	9	high	high	JJ
cord-261566-fn08b0y2	149	10	sequence	sequence	NN
cord-261566-fn08b0y2	149	11	identity	identity	NN
cord-261566-fn08b0y2	149	12	(	(	-LRB-
cord-261566-fn08b0y2	149	13	~91	~91	NFP
cord-261566-fn08b0y2	149	14	%	%	NN
cord-261566-fn08b0y2	149	15	)	)	-RRB-
cord-261566-fn08b0y2	149	16	with	with	IN
cord-261566-fn08b0y2	149	17	N	n	CD
cord-261566-fn08b0y2	149	18	protein	protein	NN
cord-261566-fn08b0y2	149	19	of	of	IN
cord-261566-fn08b0y2	149	20	SARS	SARS	NNP
cord-261566-fn08b0y2	149	21	-	-	HYPH
cord-261566-fn08b0y2	149	22	CoV	CoV	NNP
cord-261566-fn08b0y2	149	23	and	and	CC
cord-261566-fn08b0y2	149	24	hence	hence	RB
cord-261566-fn08b0y2	149	25	can	can	MD
cord-261566-fn08b0y2	149	26	be	be	VB
cord-261566-fn08b0y2	149	27	considered	consider	VBN
cord-261566-fn08b0y2	149	28	for	for	IN
cord-261566-fn08b0y2	149	29	the	the	DT
cord-261566-fn08b0y2	149	30	development	development	NN
cord-261566-fn08b0y2	149	31	of	of	IN
cord-261566-fn08b0y2	149	32	a	a	DT
cord-261566-fn08b0y2	149	33	broad	broad	JJ
cord-261566-fn08b0y2	149	34	spectrum	spectrum	NN
cord-261566-fn08b0y2	149	35	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	149	36	vaccine	vaccine	NN
cord-261566-fn08b0y2	149	37	.	.	.
cord-261566-fn08b0y2	150	1	74	74	CD
cord-261566-fn08b0y2	151	1	A	a	DT
cord-261566-fn08b0y2	151	2	challenging	challenging	JJ
cord-261566-fn08b0y2	151	3	alternative	alternative	NN
cord-261566-fn08b0y2	151	4	that	that	WDT
cord-261566-fn08b0y2	151	5	can	can	MD
cord-261566-fn08b0y2	151	6	warrant	warrant	VB
cord-261566-fn08b0y2	151	7	protection	protection	NN
cord-261566-fn08b0y2	151	8	against	against	IN
cord-261566-fn08b0y2	151	9	future	future	JJ
cord-261566-fn08b0y2	151	10	outbreaks	outbreak	NNS
cord-261566-fn08b0y2	151	11	of	of	IN
cord-261566-fn08b0y2	151	12	similar	similar	JJ
cord-261566-fn08b0y2	151	13	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	151	14	is	be	VBZ
cord-261566-fn08b0y2	151	15	to	to	TO
cord-261566-fn08b0y2	151	16	identify	identify	VB
cord-261566-fn08b0y2	151	17	a	a	DT
cord-261566-fn08b0y2	151	18	universal	universal	JJ
cord-261566-fn08b0y2	151	19	epitope	epitope	NN
cord-261566-fn08b0y2	151	20	in	in	IN
cord-261566-fn08b0y2	151	21	the	the	DT
cord-261566-fn08b0y2	151	22	whole	whole	JJ
cord-261566-fn08b0y2	151	23	virus	virus	NN
cord-261566-fn08b0y2	151	24	family	family	NN
cord-261566-fn08b0y2	151	25	or	or	CC
cord-261566-fn08b0y2	151	26	genera	genus	NNS
cord-261566-fn08b0y2	151	27	.	.	.
cord-261566-fn08b0y2	152	1	This	this	DT
cord-261566-fn08b0y2	152	2	strategy	strategy	NN
cord-261566-fn08b0y2	152	3	is	be	VBZ
cord-261566-fn08b0y2	152	4	being	be	VBG
cord-261566-fn08b0y2	152	5	undertaken	undertake	VBN
cord-261566-fn08b0y2	152	6	for	for	IN
cord-261566-fn08b0y2	152	7	influenza	influenza	NN
cord-261566-fn08b0y2	152	8	viruses	virus	NNS
cord-261566-fn08b0y2	152	9	and	and	CC
cord-261566-fn08b0y2	152	10	can	can	MD
cord-261566-fn08b0y2	152	11	be	be	VB
cord-261566-fn08b0y2	152	12	extended	extend	VBN
cord-261566-fn08b0y2	152	13	to	to	IN
cord-261566-fn08b0y2	152	14	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	152	15	as	as	RB
cord-261566-fn08b0y2	152	16	well	well	RB
cord-261566-fn08b0y2	152	17	.	.	.
cord-261566-fn08b0y2	153	1	75	75	CD
cord-261566-fn08b0y2	153	2	Immunoinformatics	Immunoinformatics	NNPS
cord-261566-fn08b0y2	153	3	can	can	MD
cord-261566-fn08b0y2	153	4	also	also	RB
cord-261566-fn08b0y2	153	5	be	be	VB
cord-261566-fn08b0y2	153	6	a	a	DT
cord-261566-fn08b0y2	153	7	powerful	powerful	JJ
cord-261566-fn08b0y2	153	8	tool	tool	NN
cord-261566-fn08b0y2	153	9	in	in	IN
cord-261566-fn08b0y2	153	10	prediction	prediction	NN
cord-261566-fn08b0y2	153	11	of	of	IN
cord-261566-fn08b0y2	153	12	epitopes	epitope	NNS
cord-261566-fn08b0y2	153	13	on	on	IN
cord-261566-fn08b0y2	153	14	the	the	DT
cord-261566-fn08b0y2	153	15	viral	viral	JJ
cord-261566-fn08b0y2	153	16	surface	surface	NN
cord-261566-fn08b0y2	153	17	proteins	protein	NNS
cord-261566-fn08b0y2	153	18	.	.	.
cord-261566-fn08b0y2	154	1	76	76	CD
cord-261566-fn08b0y2	154	2	 	 	_SP
cord-261566-fn08b0y2	155	1	Traditionally	traditionally	RB
cord-261566-fn08b0y2	155	2	,	,	,
cord-261566-fn08b0y2	155	3	mucosal	mucosal	JJ
cord-261566-fn08b0y2	155	4	immune	immune	JJ
cord-261566-fn08b0y2	155	5	induction	induction	NN
cord-261566-fn08b0y2	155	6	needs	need	VBZ
cord-261566-fn08b0y2	155	7	a	a	DT
cord-261566-fn08b0y2	155	8	higher	high	JJR
cord-261566-fn08b0y2	155	9	dose	dose	NN
cord-261566-fn08b0y2	155	10	of	of	IN
cord-261566-fn08b0y2	155	11	antigen	antigen	NN
cord-261566-fn08b0y2	155	12	in	in	IN
cord-261566-fn08b0y2	155	13	comparison	comparison	NN
cord-261566-fn08b0y2	155	14	to	to	IN
cord-261566-fn08b0y2	155	15	parenteral	parenteral	JJ
cord-261566-fn08b0y2	155	16	immunization	immunization	NN
cord-261566-fn08b0y2	155	17	as	as	IN
cord-261566-fn08b0y2	155	18	antigenic	antigenic	JJ
cord-261566-fn08b0y2	155	19	preparation	preparation	NN
cord-261566-fn08b0y2	155	20	may	may	MD
cord-261566-fn08b0y2	155	21	get	get	VB
cord-261566-fn08b0y2	155	22	diluted	dilute	VBN
cord-261566-fn08b0y2	155	23	in	in	IN
cord-261566-fn08b0y2	155	24	mucus	mucus	NN
cord-261566-fn08b0y2	155	25	in	in	IN
cord-261566-fn08b0y2	155	26	the	the	DT
cord-261566-fn08b0y2	155	27	nasal	nasal	NN
cord-261566-fn08b0y2	155	28	cavity	cavity	NN
cord-261566-fn08b0y2	155	29	or	or	CC
cord-261566-fn08b0y2	155	30	get	get	VB
cord-261566-fn08b0y2	155	31	expelled	expel	VBN
cord-261566-fn08b0y2	155	32	by	by	IN
cord-261566-fn08b0y2	155	33	mucus	mucus	NN
cord-261566-fn08b0y2	155	34	and	and	CC
cord-261566-fn08b0y2	155	35	ciliary	ciliary	NN
cord-261566-fn08b0y2	155	36	movement	movement	NN
cord-261566-fn08b0y2	155	37	in	in	IN
cord-261566-fn08b0y2	155	38	the	the	DT
cord-261566-fn08b0y2	155	39	respiratory	respiratory	JJ
cord-261566-fn08b0y2	155	40	tract	tract	NN
cord-261566-fn08b0y2	155	41	.	.	.
cord-261566-fn08b0y2	156	1	77	77	CD
cord-261566-fn08b0y2	157	1	Effective	effective	JJ
cord-261566-fn08b0y2	157	2	intranasal	intranasal	NN
cord-261566-fn08b0y2	157	3	vaccination	vaccination	NN
cord-261566-fn08b0y2	157	4	requires	require	VBZ
cord-261566-fn08b0y2	157	5	the	the	DT
cord-261566-fn08b0y2	157	6	antigen	antigen	NN
cord-261566-fn08b0y2	157	7	to	to	TO
cord-261566-fn08b0y2	157	8	reach	reach	VB
cord-261566-fn08b0y2	157	9	mucosal	mucosal	JJ
cord-261566-fn08b0y2	157	10	sites	site	NNS
cord-261566-fn08b0y2	157	11	,	,	,
cord-261566-fn08b0y2	157	12	cross	cross	VB
cord-261566-fn08b0y2	157	13	the	the	DT
cord-261566-fn08b0y2	157	14	mucus	mucus	NN
cord-261566-fn08b0y2	157	15	layer	layer	NN
cord-261566-fn08b0y2	157	16	,	,	,
cord-261566-fn08b0y2	157	17	and	and	CC
cord-261566-fn08b0y2	157	18	induce	induce	VB
cord-261566-fn08b0y2	157	19	local	local	JJ
cord-261566-fn08b0y2	157	20	IgA	IgA	NNP
cord-261566-fn08b0y2	157	21	production	production	NN
cord-261566-fn08b0y2	157	22	.	.	.
cord-261566-fn08b0y2	158	1	A	a	DT
cord-261566-fn08b0y2	158	2	vaccine	vaccine	NN
cord-261566-fn08b0y2	158	3	administered	administer	VBD
cord-261566-fn08b0y2	158	4	through	through	IN
cord-261566-fn08b0y2	158	5	the	the	DT
cord-261566-fn08b0y2	158	6	oral	oral	JJ
cord-261566-fn08b0y2	158	7	route	route	NN
cord-261566-fn08b0y2	158	8	has	have	VBZ
cord-261566-fn08b0y2	158	9	to	to	TO
cord-261566-fn08b0y2	158	10	endure	endure	VB
cord-261566-fn08b0y2	158	11	the	the	DT
cord-261566-fn08b0y2	158	12	low	low	JJ
cord-261566-fn08b0y2	158	13	pH	pH	NNP
cord-261566-fn08b0y2	158	14	environment	environment	NN
cord-261566-fn08b0y2	158	15	in	in	IN
cord-261566-fn08b0y2	158	16	the	the	DT
cord-261566-fn08b0y2	158	17	upper	upper	JJ
cord-261566-fn08b0y2	158	18	GI	GI	NNP
cord-261566-fn08b0y2	158	19	tract	tract	NN
cord-261566-fn08b0y2	158	20	and	and	CC
cord-261566-fn08b0y2	158	21	a	a	DT
cord-261566-fn08b0y2	158	22	variety	variety	NN
cord-261566-fn08b0y2	158	23	of	of	IN
cord-261566-fn08b0y2	158	24	nucleases	nuclease	NNS
cord-261566-fn08b0y2	158	25	and	and	CC
cord-261566-fn08b0y2	158	26	proteases	protease	NNS
cord-261566-fn08b0y2	158	27	present	present	JJ
cord-261566-fn08b0y2	158	28	in	in	IN
cord-261566-fn08b0y2	158	29	the	the	DT
cord-261566-fn08b0y2	158	30	digestive	digestive	JJ
cord-261566-fn08b0y2	158	31	tract	tract	NN
cord-261566-fn08b0y2	158	32	before	before	IN
cord-261566-fn08b0y2	158	33	it	-PRON-	PRP
cord-261566-fn08b0y2	158	34	can	can	MD
cord-261566-fn08b0y2	158	35	reach	reach	VB
cord-261566-fn08b0y2	158	36	the	the	DT
cord-261566-fn08b0y2	158	37	immunological	immunological	JJ
cord-261566-fn08b0y2	158	38	sites	site	NNS
cord-261566-fn08b0y2	158	39	.	.	.
cord-261566-fn08b0y2	159	1	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	159	2	antigens	antigen	NNS
cord-261566-fn08b0y2	159	3	when	when	WRB
cord-261566-fn08b0y2	159	4	administered	administer	VBN
cord-261566-fn08b0y2	159	5	alone	alone	RB
cord-261566-fn08b0y2	159	6	lead	lead	VBP
cord-261566-fn08b0y2	159	7	to	to	IN
cord-261566-fn08b0y2	159	8	a	a	DT
cord-261566-fn08b0y2	159	9	weak	weak	JJ
cord-261566-fn08b0y2	159	10	induction	induction	NN
cord-261566-fn08b0y2	159	11	of	of	IN
cord-261566-fn08b0y2	159	12	immune	immune	JJ
cord-261566-fn08b0y2	159	13	response	response	NN
cord-261566-fn08b0y2	159	14	.	.	.
cord-261566-fn08b0y2	160	1	To	to	TO
cord-261566-fn08b0y2	160	2	overcome	overcome	VB
cord-261566-fn08b0y2	160	3	these	these	DT
cord-261566-fn08b0y2	160	4	physical	physical	JJ
cord-261566-fn08b0y2	160	5	and	and	CC
cord-261566-fn08b0y2	160	6	biochemical	biochemical	JJ
cord-261566-fn08b0y2	160	7	obstacles	obstacle	NNS
cord-261566-fn08b0y2	160	8	in	in	IN
cord-261566-fn08b0y2	160	9	priming	prime	VBG
cord-261566-fn08b0y2	160	10	mucosal	mucosal	JJ
cord-261566-fn08b0y2	160	11	immune	immune	JJ
cord-261566-fn08b0y2	160	12	cells	cell	NNS
cord-261566-fn08b0y2	160	13	,	,	,
cord-261566-fn08b0y2	160	14	vaccines	vaccine	NNS
cord-261566-fn08b0y2	160	15	delivered	deliver	VBN
cord-261566-fn08b0y2	160	16	through	through	IN
cord-261566-fn08b0y2	160	17	oral	oral	JJ
cord-261566-fn08b0y2	160	18	or	or	CC
cord-261566-fn08b0y2	160	19	nasal	nasal	JJ
cord-261566-fn08b0y2	160	20	routes	route	NNS
cord-261566-fn08b0y2	160	21	are	be	VBP
cord-261566-fn08b0y2	160	22	often	often	RB
cord-261566-fn08b0y2	160	23	administered	administer	VBN
cord-261566-fn08b0y2	160	24	complemented	complement	VBD
cord-261566-fn08b0y2	160	25	with	with	IN
cord-261566-fn08b0y2	160	26	an	an	DT
cord-261566-fn08b0y2	160	27	adjuvant	adjuvant	NN
cord-261566-fn08b0y2	160	28	.	.	.
cord-261566-fn08b0y2	161	1	78	78	CD
cord-261566-fn08b0y2	161	2	Adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	161	3	are	be	VBP
cord-261566-fn08b0y2	161	4	the	the	DT
cord-261566-fn08b0y2	161	5	supplementary	supplementary	JJ
cord-261566-fn08b0y2	161	6	materials	material	NNS
cord-261566-fn08b0y2	161	7	(	(	-LRB-
cord-261566-fn08b0y2	161	8	natural	natural	JJ
cord-261566-fn08b0y2	161	9	or	or	CC
cord-261566-fn08b0y2	161	10	synthetic	synthetic	JJ
cord-261566-fn08b0y2	161	11	)	)	-RRB-
cord-261566-fn08b0y2	161	12	in	in	IN
cord-261566-fn08b0y2	161	13	a	a	DT
cord-261566-fn08b0y2	161	14	vaccine	vaccine	NN
cord-261566-fn08b0y2	161	15	formulation	formulation	NN
cord-261566-fn08b0y2	161	16	that	that	WDT
cord-261566-fn08b0y2	161	17	potentiates	potentiate	VBZ
cord-261566-fn08b0y2	161	18	the	the	DT
cord-261566-fn08b0y2	161	19	immune	immune	JJ
cord-261566-fn08b0y2	161	20	-	-	HYPH
cord-261566-fn08b0y2	161	21	induction	induction	NN
cord-261566-fn08b0y2	161	22	capacity	capacity	NN
cord-261566-fn08b0y2	161	23	of	of	IN
cord-261566-fn08b0y2	161	24	a	a	DT
cord-261566-fn08b0y2	161	25	vaccine	vaccine	NN
cord-261566-fn08b0y2	161	26	.	.	.
cord-261566-fn08b0y2	162	1	79	79	CD
cord-261566-fn08b0y2	162	2	Adjuvant	Adjuvant	NNP
cord-261566-fn08b0y2	162	3	in	in	IN
cord-261566-fn08b0y2	162	4	a	a	DT
cord-261566-fn08b0y2	162	5	vaccine	vaccine	NN
cord-261566-fn08b0y2	162	6	formulation	formulation	NN
cord-261566-fn08b0y2	162	7	plays	play	VBZ
cord-261566-fn08b0y2	162	8	a	a	DT
cord-261566-fn08b0y2	162	9	critical	critical	JJ
cord-261566-fn08b0y2	162	10	role	role	NN
cord-261566-fn08b0y2	162	11	in	in	IN
cord-261566-fn08b0y2	162	12	maintaining	maintain	VBG
cord-261566-fn08b0y2	162	13	the	the	DT
cord-261566-fn08b0y2	162	14	structural	structural	JJ
cord-261566-fn08b0y2	162	15	integrity	integrity	NN
cord-261566-fn08b0y2	162	16	of	of	IN
cord-261566-fn08b0y2	162	17	the	the	DT
cord-261566-fn08b0y2	162	18	antigen	antigen	NN
cord-261566-fn08b0y2	162	19	,	,	,
cord-261566-fn08b0y2	162	20	augmenting	augment	VBG
cord-261566-fn08b0y2	162	21	antigen	antigen	NN
cord-261566-fn08b0y2	162	22	bioavailability	bioavailability	NN
cord-261566-fn08b0y2	162	23	,	,	,
cord-261566-fn08b0y2	162	24	and	and	CC
cord-261566-fn08b0y2	162	25	enhancing	enhance	VBG
cord-261566-fn08b0y2	162	26	antigenic	antigenic	JJ
cord-261566-fn08b0y2	162	27	stimulation	stimulation	NN
cord-261566-fn08b0y2	162	28	.	.	.
cord-261566-fn08b0y2	163	1	Adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	163	2	are	be	VBP
cord-261566-fn08b0y2	163	3	broadly	broadly	RB
cord-261566-fn08b0y2	163	4	divided	divide	VBN
cord-261566-fn08b0y2	163	5	into	into	IN
cord-261566-fn08b0y2	163	6	two	two	CD
cord-261566-fn08b0y2	163	7	classes	class	NNS
cord-261566-fn08b0y2	163	8	:	:	:
cord-261566-fn08b0y2	163	9	adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	163	10	that	that	WDT
cord-261566-fn08b0y2	163	11	can	can	MD
cord-261566-fn08b0y2	163	12	serve	serve	VB
cord-261566-fn08b0y2	163	13	as	as	IN
cord-261566-fn08b0y2	163	14	carrier	carrier	NN
cord-261566-fn08b0y2	163	15	systems	system	NNS
cord-261566-fn08b0y2	163	16	to	to	TO
cord-261566-fn08b0y2	163	17	facilitate	facilitate	VB
cord-261566-fn08b0y2	163	18	antigen	antigen	NN
cord-261566-fn08b0y2	163	19	delivery	delivery	NN
cord-261566-fn08b0y2	163	20	to	to	IN
cord-261566-fn08b0y2	163	21	immune	immune	JJ
cord-261566-fn08b0y2	163	22	induction	induction	NN
cord-261566-fn08b0y2	163	23	sites	site	NNS
cord-261566-fn08b0y2	163	24	and	and	CC
cord-261566-fn08b0y2	163	25	adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	163	26	that	that	WDT
cord-261566-fn08b0y2	163	27	can	can	MD
cord-261566-fn08b0y2	163	28	act	act	VB
cord-261566-fn08b0y2	163	29	as	as	IN
cord-261566-fn08b0y2	163	30	immunostimulators	immunostimulator	NNS
cord-261566-fn08b0y2	163	31	through	through	IN
cord-261566-fn08b0y2	163	32	enhanced	enhance	VBN
cord-261566-fn08b0y2	163	33	internalization	internalization	NN
cord-261566-fn08b0y2	163	34	,	,	,
cord-261566-fn08b0y2	163	35	presentation	presentation	NN
cord-261566-fn08b0y2	163	36	,	,	,
cord-261566-fn08b0y2	163	37	and	and	CC
cord-261566-fn08b0y2	163	38	processing	processing	NN
cord-261566-fn08b0y2	163	39	of	of	IN
cord-261566-fn08b0y2	163	40	the	the	DT
cord-261566-fn08b0y2	163	41	antigen	antigen	NN
cord-261566-fn08b0y2	163	42	in	in	IN
cord-261566-fn08b0y2	163	43	the	the	DT
cord-261566-fn08b0y2	163	44	APCs	apc	NNS
cord-261566-fn08b0y2	163	45	.	.	.
cord-261566-fn08b0y2	164	1	80	80	CD
cord-261566-fn08b0y2	165	1	A	a	DT
cord-261566-fn08b0y2	165	2	number	number	NN
cord-261566-fn08b0y2	165	3	of	of	IN
cord-261566-fn08b0y2	165	4	polymers	polymer	NNS
cord-261566-fn08b0y2	165	5	including	include	VBG
cord-261566-fn08b0y2	165	6	chitosan	chitosan	NN
cord-261566-fn08b0y2	165	7	and	and	CC
cord-261566-fn08b0y2	165	8	poly	poly	JJ
cord-261566-fn08b0y2	165	9	lacticco	lacticco	NN
cord-261566-fn08b0y2	165	10	-	-	HYPH
cord-261566-fn08b0y2	165	11	glycolic	glycolic	NN
cord-261566-fn08b0y2	165	12	acid	acid	NN
cord-261566-fn08b0y2	165	13	(	(	-LRB-
cord-261566-fn08b0y2	165	14	PLGA	PLGA	NNP
cord-261566-fn08b0y2	165	15	)	)	-RRB-
cord-261566-fn08b0y2	165	16	have	have	VBP
cord-261566-fn08b0y2	165	17	been	be	VBN
cord-261566-fn08b0y2	165	18	used	use	VBN
cord-261566-fn08b0y2	165	19	as	as	IN
cord-261566-fn08b0y2	165	20	carriers	carrier	NNS
cord-261566-fn08b0y2	165	21	in	in	IN
cord-261566-fn08b0y2	165	22	various	various	JJ
cord-261566-fn08b0y2	165	23	vaccine	vaccine	NN
cord-261566-fn08b0y2	165	24	formulations	formulation	NNS
cord-261566-fn08b0y2	165	25	for	for	IN
cord-261566-fn08b0y2	165	26	immunostimulation	immunostimulation	NN
cord-261566-fn08b0y2	165	27	due	due	IN
cord-261566-fn08b0y2	165	28	to	to	IN
cord-261566-fn08b0y2	165	29	their	-PRON-	PRP$
cord-261566-fn08b0y2	165	30	high	high	JJ
cord-261566-fn08b0y2	165	31	affinity	affinity	NN
cord-261566-fn08b0y2	165	32	toward	toward	IN
cord-261566-fn08b0y2	165	33	mucosal	mucosal	JJ
cord-261566-fn08b0y2	165	34	surfaces	surface	NNS
cord-261566-fn08b0y2	165	35	.	.	.
cord-261566-fn08b0y2	166	1	81	81	CD
cord-261566-fn08b0y2	166	2	,	,	,
cord-261566-fn08b0y2	166	3	82	82	CD
cord-261566-fn08b0y2	166	4	Emulsions	emulsion	NNS
cord-261566-fn08b0y2	166	5	and	and	CC
cord-261566-fn08b0y2	166	6	liposomes	liposome	NNS
cord-261566-fn08b0y2	166	7	are	be	VBP
cord-261566-fn08b0y2	166	8	the	the	DT
cord-261566-fn08b0y2	166	9	other	other	JJ
cord-261566-fn08b0y2	166	10	carriers	carrier	NNS
cord-261566-fn08b0y2	166	11	routinely	routinely	RB
cord-261566-fn08b0y2	166	12	tested	test	VBN
cord-261566-fn08b0y2	166	13	for	for	IN
cord-261566-fn08b0y2	166	14	mucosal	mucosal	JJ
cord-261566-fn08b0y2	166	15	vaccine	vaccine	NN
cord-261566-fn08b0y2	166	16	.	.	.
cord-261566-fn08b0y2	167	1	48	48	CD
cord-261566-fn08b0y2	167	2	DC	DC	NNP
cord-261566-fn08b0y2	167	3	and	and	CC
cord-261566-fn08b0y2	167	4	M	M	NNP
cord-261566-fn08b0y2	167	5	cells	cell	NNS
cord-261566-fn08b0y2	167	6	are	be	VBP
cord-261566-fn08b0y2	167	7	a	a	DT
cord-261566-fn08b0y2	167	8	major	major	JJ
cord-261566-fn08b0y2	167	9	determinant	determinant	NN
cord-261566-fn08b0y2	167	10	for	for	IN
cord-261566-fn08b0y2	167	11	induction	induction	NN
cord-261566-fn08b0y2	167	12	of	of	IN
cord-261566-fn08b0y2	167	13	mucosal	mucosal	JJ
cord-261566-fn08b0y2	167	14	immune	immune	JJ
cord-261566-fn08b0y2	167	15	response	response	NN
cord-261566-fn08b0y2	167	16	at	at	IN
cord-261566-fn08b0y2	167	17	immune	immune	JJ
cord-261566-fn08b0y2	167	18	inductive	inductive	JJ
cord-261566-fn08b0y2	167	19	sites	site	NNS
cord-261566-fn08b0y2	167	20	and	and	CC
cord-261566-fn08b0y2	167	21	thus	thus	RB
cord-261566-fn08b0y2	167	22	represent	represent	VB
cord-261566-fn08b0y2	167	23	an	an	DT
cord-261566-fn08b0y2	167	24	ideal	ideal	JJ
cord-261566-fn08b0y2	167	25	site	site	NN
cord-261566-fn08b0y2	167	26	for	for	IN
cord-261566-fn08b0y2	167	27	antigen	antigen	NN
cord-261566-fn08b0y2	167	28	presentation	presentation	NN
cord-261566-fn08b0y2	167	29	.	.	.
cord-261566-fn08b0y2	168	1	Surface	surface	NN
cord-261566-fn08b0y2	168	2	markers	marker	NNS
cord-261566-fn08b0y2	168	3	at	at	IN
cord-261566-fn08b0y2	168	4	the	the	DT
cord-261566-fn08b0y2	168	5	surface	surface	NN
cord-261566-fn08b0y2	168	6	of	of	IN
cord-261566-fn08b0y2	168	7	epithelial	epithelial	JJ
cord-261566-fn08b0y2	168	8	cells	cell	NNS
cord-261566-fn08b0y2	168	9	and	and	CC
cord-261566-fn08b0y2	168	10	DCs	dc	NNS
cord-261566-fn08b0y2	168	11	can	can	MD
cord-261566-fn08b0y2	168	12	be	be	VB
cord-261566-fn08b0y2	168	13	strategically	strategically	RB
cord-261566-fn08b0y2	168	14	targeted	target	VBN
cord-261566-fn08b0y2	168	15	for	for	IN
cord-261566-fn08b0y2	168	16	antigen	antigen	NN
cord-261566-fn08b0y2	168	17	delivery	delivery	NN
cord-261566-fn08b0y2	168	18	with	with	IN
cord-261566-fn08b0y2	168	19	specialized	specialized	JJ
cord-261566-fn08b0y2	168	20	molecules	molecule	NNS
cord-261566-fn08b0y2	168	21	such	such	JJ
cord-261566-fn08b0y2	168	22	as	as	IN
cord-261566-fn08b0y2	168	23	lectins	lectin	NNS
cord-261566-fn08b0y2	168	24	or	or	CC
cord-261566-fn08b0y2	168	25	nanoparticles	nanoparticle	NNS
cord-261566-fn08b0y2	168	26	for	for	IN
cord-261566-fn08b0y2	168	27	increased	increase	VBN
cord-261566-fn08b0y2	168	28	antigen	antigen	NN
cord-261566-fn08b0y2	168	29	uptake	uptake	NN
cord-261566-fn08b0y2	168	30	by	by	IN
cord-261566-fn08b0y2	168	31	APCs	apc	NNS
cord-261566-fn08b0y2	168	32	.	.	.
cord-261566-fn08b0y2	169	1	83	83	CD
cord-261566-fn08b0y2	169	2	,	,	,
cord-261566-fn08b0y2	169	3	84	84	CD
cord-261566-fn08b0y2	169	4	Pathogen	pathogen	NN
cord-261566-fn08b0y2	169	5	recognition	recognition	NN
cord-261566-fn08b0y2	169	6	receptor	receptor	NN
cord-261566-fn08b0y2	169	7	agonists	agonist	NNS
cord-261566-fn08b0y2	169	8	such	such	JJ
cord-261566-fn08b0y2	169	9	as	as	IN
cord-261566-fn08b0y2	169	10	synthetic	synthetic	JJ
cord-261566-fn08b0y2	169	11	poly-(I	poly-(I	NNP
cord-261566-fn08b0y2	169	12	:	:	:
cord-261566-fn08b0y2	169	13	C	C	NNP
cord-261566-fn08b0y2	169	14	)	)	-RRB-
cord-261566-fn08b0y2	169	15	,	,	,
cord-261566-fn08b0y2	169	16	or	or	CC
cord-261566-fn08b0y2	169	17	toll	toll	NN
cord-261566-fn08b0y2	169	18	like	like	IN
cord-261566-fn08b0y2	169	19	receptor	receptor	NN
cord-261566-fn08b0y2	169	20	agonists	agonist	NNS
cord-261566-fn08b0y2	169	21	such	such	JJ
cord-261566-fn08b0y2	169	22	as	as	IN
cord-261566-fn08b0y2	169	23	CpG	CpG	NNP
cord-261566-fn08b0y2	169	24	oligodeoxynucleotides	oligodeoxynucleotides	NNP
cord-261566-fn08b0y2	169	25	,	,	,
cord-261566-fn08b0y2	169	26	engage	engage	VB
cord-261566-fn08b0y2	169	27	these	these	DT
cord-261566-fn08b0y2	169	28	receptors	receptor	NNS
cord-261566-fn08b0y2	169	29	present	present	JJ
cord-261566-fn08b0y2	169	30	on	on	IN
cord-261566-fn08b0y2	169	31	the	the	DT
cord-261566-fn08b0y2	169	32	surface	surface	NN
cord-261566-fn08b0y2	169	33	of	of	IN
cord-261566-fn08b0y2	169	34	APCs	apc	NNS
cord-261566-fn08b0y2	169	35	to	to	TO
cord-261566-fn08b0y2	169	36	potentiate	potentiate	VB
cord-261566-fn08b0y2	169	37	the	the	DT
cord-261566-fn08b0y2	169	38	immunogenicity	immunogenicity	NN
cord-261566-fn08b0y2	169	39	of	of	IN
cord-261566-fn08b0y2	169	40	the	the	DT
cord-261566-fn08b0y2	169	41	vaccine	vaccine	NN
cord-261566-fn08b0y2	169	42	.	.	.
cord-261566-fn08b0y2	170	1	85	85	CD
cord-261566-fn08b0y2	170	2	,	,	,
cord-261566-fn08b0y2	170	3	86	86	CD
cord-261566-fn08b0y2	170	4	Other	other	JJ
cord-261566-fn08b0y2	170	5	commonly	commonly	RB
cord-261566-fn08b0y2	170	6	used	use	VBD
cord-261566-fn08b0y2	170	7	adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	170	8	including	include	VBG
cord-261566-fn08b0y2	170	9	cholera	cholera	NN
cord-261566-fn08b0y2	170	10	enterotoxin	enterotoxin	NNP
cord-261566-fn08b0y2	170	11	(	(	-LRB-
cord-261566-fn08b0y2	170	12	CT	CT	NNP
cord-261566-fn08b0y2	170	13	)	)	-RRB-
cord-261566-fn08b0y2	170	14	and	and	CC
cord-261566-fn08b0y2	170	15	heat	heat	NN
cord-261566-fn08b0y2	170	16	-	-	HYPH
cord-261566-fn08b0y2	170	17	labile	labile	JJ
cord-261566-fn08b0y2	170	18	enterotoxin	enterotoxin	NN
cord-261566-fn08b0y2	170	19	(	(	-LRB-
cord-261566-fn08b0y2	170	20	LT	LT	NNP
cord-261566-fn08b0y2	170	21	)	)	-RRB-
cord-261566-fn08b0y2	170	22	from	from	IN
cord-261566-fn08b0y2	170	23	E.	E.	NNP
cord-261566-fn08b0y2	170	24	coli	coli	NNS
cord-261566-fn08b0y2	170	25	exert	exert	VBP
cord-261566-fn08b0y2	170	26	their	-PRON-	PRP$
cord-261566-fn08b0y2	170	27	adjuvanticity	adjuvanticity	NN
cord-261566-fn08b0y2	170	28	by	by	IN
cord-261566-fn08b0y2	170	29	interacting	interact	VBG
cord-261566-fn08b0y2	170	30	with	with	IN
cord-261566-fn08b0y2	170	31	GM1	GM1	NNP
cord-261566-fn08b0y2	170	32	gangliosides	gangliosides	NNP
cord-261566-fn08b0y2	170	33	on	on	IN
cord-261566-fn08b0y2	170	34	the	the	DT
cord-261566-fn08b0y2	170	35	surface	surface	NN
cord-261566-fn08b0y2	170	36	of	of	IN
cord-261566-fn08b0y2	170	37	follicular	follicular	JJ
cord-261566-fn08b0y2	170	38	dendritic	dendritic	JJ
cord-261566-fn08b0y2	170	39	cells	cell	NNS
cord-261566-fn08b0y2	170	40	and	and	CC
cord-261566-fn08b0y2	170	41	in	in	IN
cord-261566-fn08b0y2	170	42	turn	turn	NN
cord-261566-fn08b0y2	170	43	increase	increase	VB
cord-261566-fn08b0y2	170	44	the	the	DT
cord-261566-fn08b0y2	170	45	induction	induction	NN
cord-261566-fn08b0y2	170	46	of	of	IN
cord-261566-fn08b0y2	170	47	B	b	NN
cord-261566-fn08b0y2	170	48	-	-	HYPH
cord-261566-fn08b0y2	170	49	cell	cell	NN
cord-261566-fn08b0y2	170	50	clones	clone	NNS
cord-261566-fn08b0y2	170	51	.	.	.
cord-261566-fn08b0y2	171	1	87	87	CD
cord-261566-fn08b0y2	172	1	The	the	DT
cord-261566-fn08b0y2	172	2	use	use	NN
cord-261566-fn08b0y2	172	3	of	of	IN
cord-261566-fn08b0y2	172	4	immune	immune	NN
cord-261566-fn08b0y2	172	5	-	-	HYPH
cord-261566-fn08b0y2	172	6	stimulating	stimulate	VBG
cord-261566-fn08b0y2	172	7	complexes	complex	NNS
cord-261566-fn08b0y2	172	8	(	(	-LRB-
cord-261566-fn08b0y2	172	9	ISCOMs	iscom	NNS
cord-261566-fn08b0y2	172	10	)	)	-RRB-
cord-261566-fn08b0y2	172	11	has	have	VBZ
cord-261566-fn08b0y2	172	12	also	also	RB
cord-261566-fn08b0y2	172	13	proven	prove	VBN
cord-261566-fn08b0y2	172	14	to	to	TO
cord-261566-fn08b0y2	172	15	be	be	VB
cord-261566-fn08b0y2	172	16	highly	highly	RB
cord-261566-fn08b0y2	172	17	effective	effective	JJ
cord-261566-fn08b0y2	172	18	for	for	IN
cord-261566-fn08b0y2	172	19	administration	administration	NN
cord-261566-fn08b0y2	172	20	with	with	IN
cord-261566-fn08b0y2	172	21	mucosal	mucosal	JJ
cord-261566-fn08b0y2	172	22	vaccines	vaccine	NNS
cord-261566-fn08b0y2	172	23	.	.	.
cord-261566-fn08b0y2	173	1	88	88	CD
cord-261566-fn08b0y2	174	1	One	one	CD
cord-261566-fn08b0y2	174	2	of	of	IN
cord-261566-fn08b0y2	174	3	the	the	DT
cord-261566-fn08b0y2	174	4	major	major	JJ
cord-261566-fn08b0y2	174	5	factors	factor	NNS
cord-261566-fn08b0y2	174	6	influencing	influence	VBG
cord-261566-fn08b0y2	174	7	the	the	DT
cord-261566-fn08b0y2	174	8	rational	rational	JJ
cord-261566-fn08b0y2	174	9	design	design	NN
cord-261566-fn08b0y2	174	10	of	of	IN
cord-261566-fn08b0y2	174	11	a	a	DT
cord-261566-fn08b0y2	174	12	mucosal	mucosal	JJ
cord-261566-fn08b0y2	174	13	vaccine	vaccine	NN
cord-261566-fn08b0y2	174	14	is	be	VBZ
cord-261566-fn08b0y2	174	15	immunotolerance	immunotolerance	NNP
cord-261566-fn08b0y2	174	16	at	at	IN
cord-261566-fn08b0y2	174	17	the	the	DT
cord-261566-fn08b0y2	174	18	mucosal	mucosal	JJ
cord-261566-fn08b0y2	174	19	sites	site	NNS
cord-261566-fn08b0y2	174	20	.	.	.
cord-261566-fn08b0y2	175	1	Immunotolerance	Immunotolerance	NNP
cord-261566-fn08b0y2	175	2	is	be	VBZ
cord-261566-fn08b0y2	175	3	the	the	DT
cord-261566-fn08b0y2	175	4	ingenious	ingenious	JJ
cord-261566-fn08b0y2	175	5	modulation	modulation	NN
cord-261566-fn08b0y2	175	6	of	of	IN
cord-261566-fn08b0y2	175	7	the	the	DT
cord-261566-fn08b0y2	175	8	mucosal	mucosal	JJ
cord-261566-fn08b0y2	175	9	microenvironment	microenvironment	NN
cord-261566-fn08b0y2	175	10	to	to	TO
cord-261566-fn08b0y2	175	11	avoid	avoid	VB
cord-261566-fn08b0y2	175	12	unnecessary	unnecessary	JJ
cord-261566-fn08b0y2	175	13	induction	induction	NN
cord-261566-fn08b0y2	175	14	of	of	IN
cord-261566-fn08b0y2	175	15	host	host	NN
cord-261566-fn08b0y2	175	16	immune	immune	JJ
cord-261566-fn08b0y2	175	17	cells	cell	NNS
cord-261566-fn08b0y2	175	18	against	against	IN
cord-261566-fn08b0y2	175	19	foreign	foreign	JJ
cord-261566-fn08b0y2	175	20	antigens	antigen	NNS
cord-261566-fn08b0y2	175	21	or	or	CC
cord-261566-fn08b0y2	175	22	commensal	commensal	JJ
cord-261566-fn08b0y2	175	23	microbes	microbe	NNS
cord-261566-fn08b0y2	175	24	.	.	.
cord-261566-fn08b0y2	176	1	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	176	2	surfaces	surface	NNS
cord-261566-fn08b0y2	176	3	are	be	VBP
cord-261566-fn08b0y2	176	4	exposed	expose	VBN
cord-261566-fn08b0y2	176	5	continuously	continuously	RB
cord-261566-fn08b0y2	176	6	to	to	IN
cord-261566-fn08b0y2	176	7	environmental	environmental	JJ
cord-261566-fn08b0y2	176	8	,	,	,
cord-261566-fn08b0y2	176	9	food	food	NN
cord-261566-fn08b0y2	176	10	,	,	,
cord-261566-fn08b0y2	176	11	or	or	CC
cord-261566-fn08b0y2	176	12	self	self	NN
cord-261566-fn08b0y2	176	13	-	-	HYPH
cord-261566-fn08b0y2	176	14	antigens	antigen	NNS
cord-261566-fn08b0y2	176	15	which	which	WDT
cord-261566-fn08b0y2	176	16	lead	lead	VBP
cord-261566-fn08b0y2	176	17	to	to	IN
cord-261566-fn08b0y2	176	18	the	the	DT
cord-261566-fn08b0y2	176	19	development	development	NN
cord-261566-fn08b0y2	176	20	of	of	IN
cord-261566-fn08b0y2	176	21	a	a	DT
cord-261566-fn08b0y2	176	22	tolerogenic	tolerogenic	JJ
cord-261566-fn08b0y2	176	23	microenvironment	microenvironment	NN
cord-261566-fn08b0y2	176	24	,	,	,
cord-261566-fn08b0y2	176	25	especially	especially	RB
cord-261566-fn08b0y2	176	26	in	in	IN
cord-261566-fn08b0y2	176	27	gastric	gastric	JJ
cord-261566-fn08b0y2	176	28	mucosa	mucosa	NN
cord-261566-fn08b0y2	176	29	.	.	.
cord-261566-fn08b0y2	177	1	89	89	CD
cord-261566-fn08b0y2	178	1	Some	some	DT
cord-261566-fn08b0y2	178	2	vaccination	vaccination	NN
cord-261566-fn08b0y2	178	3	strategies	strategy	NNS
cord-261566-fn08b0y2	178	4	fail	fail	VBP
cord-261566-fn08b0y2	178	5	to	to	TO
cord-261566-fn08b0y2	178	6	develop	develop	VB
cord-261566-fn08b0y2	178	7	effective	effective	JJ
cord-261566-fn08b0y2	178	8	immunity	immunity	NN
cord-261566-fn08b0y2	178	9	and	and	CC
cord-261566-fn08b0y2	178	10	can	can	MD
cord-261566-fn08b0y2	178	11	induce	induce	VB
cord-261566-fn08b0y2	178	12	immunotolerance	immunotolerance	NNS
cord-261566-fn08b0y2	178	13	.	.	.
cord-261566-fn08b0y2	179	1	This	this	DT
cord-261566-fn08b0y2	179	2	suppression	suppression	NN
cord-261566-fn08b0y2	179	3	of	of	IN
cord-261566-fn08b0y2	179	4	immune	immune	JJ
cord-261566-fn08b0y2	179	5	response	response	NN
cord-261566-fn08b0y2	179	6	is	be	VBZ
cord-261566-fn08b0y2	179	7	affected	affect	VBN
cord-261566-fn08b0y2	179	8	mainly	mainly	RB
cord-261566-fn08b0y2	179	9	by	by	IN
cord-261566-fn08b0y2	179	10	vaccine	vaccine	NN
cord-261566-fn08b0y2	179	11	formulation	formulation	NN
cord-261566-fn08b0y2	179	12	,	,	,
cord-261566-fn08b0y2	179	13	antigenic	antigenic	JJ
cord-261566-fn08b0y2	179	14	dose	dose	NN
cord-261566-fn08b0y2	179	15	,	,	,
cord-261566-fn08b0y2	179	16	and	and	CC
cord-261566-fn08b0y2	179	17	frequency	frequency	NN
cord-261566-fn08b0y2	179	18	of	of	IN
cord-261566-fn08b0y2	179	19	administration	administration	NN
cord-261566-fn08b0y2	179	20	.	.	.
cord-261566-fn08b0y2	180	1	Administration	Administration	NNP
cord-261566-fn08b0y2	180	2	of	of	IN
cord-261566-fn08b0y2	180	3	antigen	antigen	NNP
cord-261566-fn08b0y2	180	4	at	at	IN
cord-261566-fn08b0y2	180	5	low	low	JJ
cord-261566-fn08b0y2	180	6	doses	dose	NNS
cord-261566-fn08b0y2	180	7	for	for	IN
cord-261566-fn08b0y2	180	8	a	a	DT
cord-261566-fn08b0y2	180	9	long	long	JJ
cord-261566-fn08b0y2	180	10	time	time	NN
cord-261566-fn08b0y2	180	11	leads	lead	VBZ
cord-261566-fn08b0y2	180	12	to	to	IN
cord-261566-fn08b0y2	180	13	low	low	JJ
cord-261566-fn08b0y2	180	14	-	-	HYPH
cord-261566-fn08b0y2	180	15	dose	dose	NN
cord-261566-fn08b0y2	180	16	immunotolerance	immunotolerance	NN
cord-261566-fn08b0y2	180	17	.	.	.
cord-261566-fn08b0y2	181	1	48	48	CD
cord-261566-fn08b0y2	182	1	Contrastingly	contrastingly	RB
cord-261566-fn08b0y2	182	2	,	,	,
cord-261566-fn08b0y2	182	3	high	high	JJ
cord-261566-fn08b0y2	182	4	dose	dose	NN
cord-261566-fn08b0y2	182	5	of	of	IN
cord-261566-fn08b0y2	182	6	antigen	antigen	NN
cord-261566-fn08b0y2	182	7	administered	administer	VBN
cord-261566-fn08b0y2	182	8	at	at	IN
cord-261566-fn08b0y2	182	9	a	a	DT
cord-261566-fn08b0y2	182	10	low	low	JJ
cord-261566-fn08b0y2	182	11	rate	rate	NN
cord-261566-fn08b0y2	182	12	induces	induce	VBZ
cord-261566-fn08b0y2	182	13	high	high	JJ
cord-261566-fn08b0y2	182	14	-	-	HYPH
cord-261566-fn08b0y2	182	15	dose	dose	NN
cord-261566-fn08b0y2	182	16	tolerance	tolerance	NN
cord-261566-fn08b0y2	182	17	instead	instead	RB
cord-261566-fn08b0y2	182	18	of	of	IN
cord-261566-fn08b0y2	182	19	immunostimulation	immunostimulation	NN
cord-261566-fn08b0y2	182	20	.	.	.
cord-261566-fn08b0y2	183	1	This	this	DT
cord-261566-fn08b0y2	183	2	hypo	hypo	NN
cord-261566-fn08b0y2	183	3	-	-	NN
cord-261566-fn08b0y2	183	4	responsiveness	responsiveness	NN
cord-261566-fn08b0y2	183	5	at	at	IN
cord-261566-fn08b0y2	183	6	the	the	DT
cord-261566-fn08b0y2	183	7	mucosal	mucosal	JJ
cord-261566-fn08b0y2	183	8	induction	induction	NN
cord-261566-fn08b0y2	183	9	sites	site	NNS
cord-261566-fn08b0y2	183	10	can	can	MD
cord-261566-fn08b0y2	183	11	be	be	VB
cord-261566-fn08b0y2	183	12	overcome	overcome	VBN
cord-261566-fn08b0y2	183	13	by	by	IN
cord-261566-fn08b0y2	183	14	strategically	strategically	RB
cord-261566-fn08b0y2	183	15	determining	determine	VBG
cord-261566-fn08b0y2	183	16	the	the	DT
cord-261566-fn08b0y2	183	17	antigen	antigen	NN
cord-261566-fn08b0y2	183	18	dose	dose	NN
cord-261566-fn08b0y2	183	19	,	,	,
cord-261566-fn08b0y2	183	20	vaccine	vaccine	NN
cord-261566-fn08b0y2	183	21	formulation	formulation	NN
cord-261566-fn08b0y2	183	22	,	,	,
cord-261566-fn08b0y2	183	23	and	and	CC
cord-261566-fn08b0y2	183	24	timing	timing	NN
cord-261566-fn08b0y2	183	25	of	of	IN
cord-261566-fn08b0y2	183	26	vaccine	vaccine	NN
cord-261566-fn08b0y2	183	27	delivery	delivery	NN
cord-261566-fn08b0y2	183	28	.	.	.
cord-261566-fn08b0y2	184	1	The	the	DT
cord-261566-fn08b0y2	184	2	design	design	NN
cord-261566-fn08b0y2	184	3	of	of	IN
cord-261566-fn08b0y2	184	4	a	a	DT
cord-261566-fn08b0y2	184	5	novel	novel	JJ
cord-261566-fn08b0y2	184	6	mucosal	mucosal	JJ
cord-261566-fn08b0y2	184	7	vaccine	vaccine	NN
cord-261566-fn08b0y2	184	8	also	also	RB
cord-261566-fn08b0y2	184	9	aims	aim	VBZ
cord-261566-fn08b0y2	184	10	at	at	IN
cord-261566-fn08b0y2	184	11	mimicking	mimic	VBG
cord-261566-fn08b0y2	184	12	the	the	DT
cord-261566-fn08b0y2	184	13	kinetics	kinetic	NNS
cord-261566-fn08b0y2	184	14	of	of	IN
cord-261566-fn08b0y2	184	15	pathogen	pathogen	NN
cord-261566-fn08b0y2	184	16	infection	infection	NN
cord-261566-fn08b0y2	184	17	for	for	IN
cord-261566-fn08b0y2	184	18	increasing	increase	VBG
cord-261566-fn08b0y2	184	19	the	the	DT
cord-261566-fn08b0y2	184	20	clinical	clinical	JJ
cord-261566-fn08b0y2	184	21	efficacy	efficacy	NN
cord-261566-fn08b0y2	184	22	of	of	IN
cord-261566-fn08b0y2	184	23	the	the	DT
cord-261566-fn08b0y2	184	24	vaccine	vaccine	NN
cord-261566-fn08b0y2	184	25	.	.	.
cord-261566-fn08b0y2	185	1	Optimal	optimal	JJ
cord-261566-fn08b0y2	185	2	release	release	NN
cord-261566-fn08b0y2	185	3	timing	timing	NN
cord-261566-fn08b0y2	185	4	of	of	IN
cord-261566-fn08b0y2	185	5	antigen	antigen	NN
cord-261566-fn08b0y2	185	6	at	at	IN
cord-261566-fn08b0y2	185	7	the	the	DT
cord-261566-fn08b0y2	185	8	inductive	inductive	JJ
cord-261566-fn08b0y2	185	9	site	site	NN
cord-261566-fn08b0y2	185	10	helps	help	VBZ
cord-261566-fn08b0y2	185	11	in	in	IN
cord-261566-fn08b0y2	185	12	dodging	dodge	VBG
cord-261566-fn08b0y2	185	13	the	the	DT
cord-261566-fn08b0y2	185	14	mucosal	mucosal	JJ
cord-261566-fn08b0y2	185	15	immunotolerance	immunotolerance	NNS
cord-261566-fn08b0y2	185	16	.	.	.
cord-261566-fn08b0y2	186	1	To	to	IN
cord-261566-fn08b0y2	186	2	this	this	DT
cord-261566-fn08b0y2	186	3	end	end	NN
cord-261566-fn08b0y2	186	4	,	,	,
cord-261566-fn08b0y2	186	5	the	the	DT
cord-261566-fn08b0y2	186	6	antigen	antigen	NN
cord-261566-fn08b0y2	186	7	is	be	VBZ
cord-261566-fn08b0y2	186	8	conjugated	conjugate	VBN
cord-261566-fn08b0y2	186	9	with	with	IN
cord-261566-fn08b0y2	186	10	adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	186	11	like	like	IN
cord-261566-fn08b0y2	186	12	TLR	TLR	NNP
cord-261566-fn08b0y2	186	13	ligands	ligand	NNS
cord-261566-fn08b0y2	186	14	or	or	CC
cord-261566-fn08b0y2	186	15	CD-40	CD-40	NNP
cord-261566-fn08b0y2	186	16	specific	specific	JJ
cord-261566-fn08b0y2	186	17	antibodies	antibody	NNS
cord-261566-fn08b0y2	186	18	.	.	.
cord-261566-fn08b0y2	187	1	90	90	CD
cord-261566-fn08b0y2	187	2	,	,	,
cord-261566-fn08b0y2	187	3	91	91	CD
cord-261566-fn08b0y2	187	4	Immunosenescence	Immunosenescence	NNP
cord-261566-fn08b0y2	187	5	Several	several	JJ
cord-261566-fn08b0y2	187	6	issues	issue	NNS
cord-261566-fn08b0y2	187	7	are	be	VBP
cord-261566-fn08b0y2	187	8	needed	need	VBN
cord-261566-fn08b0y2	187	9	to	to	TO
cord-261566-fn08b0y2	187	10	be	be	VB
cord-261566-fn08b0y2	187	11	addressed	address	VBN
cord-261566-fn08b0y2	187	12	for	for	IN
cord-261566-fn08b0y2	187	13	the	the	DT
cord-261566-fn08b0y2	187	14	design	design	NN
cord-261566-fn08b0y2	187	15	and	and	CC
cord-261566-fn08b0y2	187	16	development	development	NN
cord-261566-fn08b0y2	187	17	of	of	IN
cord-261566-fn08b0y2	187	18	an	an	DT
cord-261566-fn08b0y2	187	19	efficacious	efficacious	JJ
cord-261566-fn08b0y2	187	20	mucosal	mucosal	JJ
cord-261566-fn08b0y2	187	21	vaccine	vaccine	NN
cord-261566-fn08b0y2	187	22	against	against	IN
cord-261566-fn08b0y2	187	23	SARS	SARS	NNP
cord-261566-fn08b0y2	187	24	-	-	HYPH
cord-261566-fn08b0y2	187	25	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	187	26	.	.	.
cord-261566-fn08b0y2	188	1	It	-PRON-	PRP
cord-261566-fn08b0y2	188	2	has	have	VBZ
cord-261566-fn08b0y2	188	3	been	be	VBN
cord-261566-fn08b0y2	188	4	observed	observe	VBN
cord-261566-fn08b0y2	188	5	in	in	IN
cord-261566-fn08b0y2	188	6	human	human	JJ
cord-261566-fn08b0y2	188	7	challenge	challenge	NN
cord-261566-fn08b0y2	188	8	studies	study	NNS
cord-261566-fn08b0y2	188	9	that	that	IN
cord-261566-fn08b0y2	188	10	immunity	immunity	NN
cord-261566-fn08b0y2	188	11	acquired	acquire	VBN
cord-261566-fn08b0y2	188	12	with	with	IN
cord-261566-fn08b0y2	188	13	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	188	14	infection	infection	NN
cord-261566-fn08b0y2	188	15	is	be	VBZ
cord-261566-fn08b0y2	188	16	often	often	RB
cord-261566-fn08b0y2	188	17	shortlived	shortlived	JJ
cord-261566-fn08b0y2	188	18	and	and	CC
cord-261566-fn08b0y2	188	19	in	in	IN
cord-261566-fn08b0y2	188	20	some	some	DT
cord-261566-fn08b0y2	188	21	cases	case	NNS
cord-261566-fn08b0y2	188	22	,	,	,
cord-261566-fn08b0y2	188	23	re	re	NN
cord-261566-fn08b0y2	188	24	-	-	NN
cord-261566-fn08b0y2	188	25	infection	infection	NN
cord-261566-fn08b0y2	188	26	with	with	IN
cord-261566-fn08b0y2	188	27	the	the	DT
cord-261566-fn08b0y2	188	28	same	same	JJ
cord-261566-fn08b0y2	188	29	virus	virus	NN
cord-261566-fn08b0y2	188	30	was	be	VBD
cord-261566-fn08b0y2	188	31	possible	possible	JJ
cord-261566-fn08b0y2	188	32	after	after	IN
cord-261566-fn08b0y2	188	33	an	an	DT
cord-261566-fn08b0y2	188	34	extended	extended	JJ
cord-261566-fn08b0y2	188	35	period	period	NN
cord-261566-fn08b0y2	188	36	.	.	.
cord-261566-fn08b0y2	189	1	92	92	CD
cord-261566-fn08b0y2	190	1	It	-PRON-	PRP
cord-261566-fn08b0y2	190	2	was	be	VBD
cord-261566-fn08b0y2	190	3	reported	report	VBN
cord-261566-fn08b0y2	190	4	in	in	IN
cord-261566-fn08b0y2	190	5	some	some	DT
cord-261566-fn08b0y2	190	6	cases	case	NNS
cord-261566-fn08b0y2	190	7	that	that	WDT
cord-261566-fn08b0y2	190	8	immunity	immunity	NN
cord-261566-fn08b0y2	190	9	acquired	acquire	VBN
cord-261566-fn08b0y2	190	10	with	with	IN
cord-261566-fn08b0y2	190	11	SARS	SARS	NNP
cord-261566-fn08b0y2	190	12	-	-	HYPH
cord-261566-fn08b0y2	190	13	CoV	CoV	NNP
cord-261566-fn08b0y2	190	14	or	or	CC
cord-261566-fn08b0y2	190	15	MERS	MERS	NNP
cord-261566-fn08b0y2	190	16	-	-	HYPH
cord-261566-fn08b0y2	190	17	CoV	CoV	NNP
cord-261566-fn08b0y2	190	18	also	also	RB
cord-261566-fn08b0y2	190	19	declines	decline	VBZ
cord-261566-fn08b0y2	190	20	considerably	considerably	RB
cord-261566-fn08b0y2	190	21	2	2	CD
cord-261566-fn08b0y2	190	22	-	-	SYM
cord-261566-fn08b0y2	190	23	3	3	CD
cord-261566-fn08b0y2	190	24	years	year	NNS
cord-261566-fn08b0y2	190	25	after	after	IN
cord-261566-fn08b0y2	190	26	viral	viral	JJ
cord-261566-fn08b0y2	190	27	infection	infection	NN
cord-261566-fn08b0y2	190	28	.	.	.
cord-261566-fn08b0y2	191	1	93	93	CD
cord-261566-fn08b0y2	191	2	,	,	,
cord-261566-fn08b0y2	191	3	94	94	CD
cord-261566-fn08b0y2	192	1	Another	another	DT
cord-261566-fn08b0y2	192	2	concern	concern	NN
cord-261566-fn08b0y2	192	3	for	for	IN
cord-261566-fn08b0y2	192	4	designing	design	VBG
cord-261566-fn08b0y2	192	5	a	a	DT
cord-261566-fn08b0y2	192	6	vaccine	vaccine	NN
cord-261566-fn08b0y2	192	7	against	against	IN
cord-261566-fn08b0y2	192	8	SARS	SARS	NNP
cord-261566-fn08b0y2	192	9	-	-	HYPH
cord-261566-fn08b0y2	192	10	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	192	11	is	be	VBZ
cord-261566-fn08b0y2	192	12	that	that	IN
cord-261566-fn08b0y2	192	13	the	the	DT
cord-261566-fn08b0y2	192	14	viral	viral	JJ
cord-261566-fn08b0y2	192	15	infection	infection	NN
cord-261566-fn08b0y2	192	16	is	be	VBZ
cord-261566-fn08b0y2	192	17	associated	associate	VBN
cord-261566-fn08b0y2	192	18	with	with	IN
cord-261566-fn08b0y2	192	19	severe	severe	JJ
cord-261566-fn08b0y2	192	20	pathology	pathology	NN
cord-261566-fn08b0y2	192	21	specifically	specifically	RB
cord-261566-fn08b0y2	192	22	in	in	IN
cord-261566-fn08b0y2	192	23	patients	patient	NNS
cord-261566-fn08b0y2	192	24	of	of	IN
cord-261566-fn08b0y2	192	25	higher	high	JJR
cord-261566-fn08b0y2	192	26	age	age	NN
cord-261566-fn08b0y2	192	27	group	group	NN
cord-261566-fn08b0y2	192	28	(	(	-LRB-
cord-261566-fn08b0y2	192	29	typically	typically	RB
cord-261566-fn08b0y2	192	30	>	>	XX
cord-261566-fn08b0y2	192	31	50	50	CD
cord-261566-fn08b0y2	192	32	years	year	NNS
cord-261566-fn08b0y2	192	33	)	)	-RRB-
cord-261566-fn08b0y2	192	34	.	.	.
cord-261566-fn08b0y2	193	1	14	14	CD
cord-261566-fn08b0y2	193	2	People	People	NNS
cord-261566-fn08b0y2	193	3	in	in	IN
cord-261566-fn08b0y2	193	4	this	this	DT
cord-261566-fn08b0y2	193	5	age	age	NN
cord-261566-fn08b0y2	193	6	group	group	NN
cord-261566-fn08b0y2	193	7	do	do	VBP
cord-261566-fn08b0y2	193	8	not	not	RB
cord-261566-fn08b0y2	193	9	respond	respond	VB
cord-261566-fn08b0y2	193	10	very	very	RB
cord-261566-fn08b0y2	193	11	well	well	RB
cord-261566-fn08b0y2	193	12	to	to	IN
cord-261566-fn08b0y2	193	13	vaccination	vaccination	NN
cord-261566-fn08b0y2	193	14	in	in	IN
cord-261566-fn08b0y2	193	15	terms	term	NNS
cord-261566-fn08b0y2	193	16	of	of	IN
cord-261566-fn08b0y2	193	17	neutralizing	neutralize	VBG
cord-261566-fn08b0y2	193	18	antibody	antibody	NN
cord-261566-fn08b0y2	193	19	titers	titer	NNS
cord-261566-fn08b0y2	193	20	and	and	CC
cord-261566-fn08b0y2	193	21	require	require	VBP
cord-261566-fn08b0y2	193	22	a	a	DT
cord-261566-fn08b0y2	193	23	higher	high	JJR
cord-261566-fn08b0y2	193	24	amount	amount	NN
cord-261566-fn08b0y2	193	25	of	of	IN
cord-261566-fn08b0y2	193	26	antigen	antigen	NN
cord-261566-fn08b0y2	193	27	to	to	TO
cord-261566-fn08b0y2	193	28	produce	produce	VB
cord-261566-fn08b0y2	193	29	sufficient	sufficient	JJ
cord-261566-fn08b0y2	193	30	immunogenicity	immunogenicity	NN
cord-261566-fn08b0y2	193	31	.	.	.
cord-261566-fn08b0y2	194	1	Specialized	Specialized	NNP
cord-261566-fn08b0y2	194	2	dose	dose	NN
cord-261566-fn08b0y2	194	3	-	-	HYPH
cord-261566-fn08b0y2	194	4	regime	regime	NN
cord-261566-fn08b0y2	194	5	in	in	IN
cord-261566-fn08b0y2	194	6	terms	term	NNS
cord-261566-fn08b0y2	194	7	of	of	IN
cord-261566-fn08b0y2	194	8	the	the	DT
cord-261566-fn08b0y2	194	9	amount	amount	NN
cord-261566-fn08b0y2	194	10	of	of	IN
cord-261566-fn08b0y2	194	11	antigen	antigen	NN
cord-261566-fn08b0y2	194	12	,	,	,
cord-261566-fn08b0y2	194	13	use	use	NN
cord-261566-fn08b0y2	194	14	of	of	IN
cord-261566-fn08b0y2	194	15	specific	specific	JJ
cord-261566-fn08b0y2	194	16	adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	194	17	,	,	,
cord-261566-fn08b0y2	194	18	or	or	CC
cord-261566-fn08b0y2	194	19	the	the	DT
cord-261566-fn08b0y2	194	20	immunization	immunization	NN
cord-261566-fn08b0y2	194	21	effects	effect	NNS
cord-261566-fn08b0y2	194	22	of	of	IN
cord-261566-fn08b0y2	194	23	follow	follow	VB
cord-261566-fn08b0y2	194	24	-	-	HYPH
cord-261566-fn08b0y2	194	25	up	up	RP
cord-261566-fn08b0y2	194	26	doses	dose	NNS
cord-261566-fn08b0y2	194	27	after	after	IN
cord-261566-fn08b0y2	194	28	a	a	DT
cord-261566-fn08b0y2	194	29	single	single	JJ
cord-261566-fn08b0y2	194	30	prime	prime	JJ
cord-261566-fn08b0y2	194	31	dose	dose	NN
cord-261566-fn08b0y2	194	32	can	can	MD
cord-261566-fn08b0y2	194	33	be	be	VB
cord-261566-fn08b0y2	194	34	investigated	investigate	VBN
cord-261566-fn08b0y2	194	35	in	in	IN
cord-261566-fn08b0y2	194	36	vulnerable	vulnerable	JJ
cord-261566-fn08b0y2	194	37	age	age	NN
cord-261566-fn08b0y2	194	38	groups	group	NNS
cord-261566-fn08b0y2	194	39	and	and	CC
cord-261566-fn08b0y2	194	40	immunocompromised	immunocompromised	JJ
cord-261566-fn08b0y2	194	41	people	people	NNS
cord-261566-fn08b0y2	194	42	before	before	IN
cord-261566-fn08b0y2	194	43	extending	extend	VBG
cord-261566-fn08b0y2	194	44	vaccination	vaccination	NN
cord-261566-fn08b0y2	194	45	to	to	IN
cord-261566-fn08b0y2	194	46	them	-PRON-	PRP
cord-261566-fn08b0y2	194	47	.	.	.
cord-261566-fn08b0y2	195	1	For	for	IN
cord-261566-fn08b0y2	195	2	most	most	JJS
cord-261566-fn08b0y2	195	3	parenterally	parenterally	NN
cord-261566-fn08b0y2	195	4	administered	administer	VBN
cord-261566-fn08b0y2	195	5	vaccines	vaccine	NNS
cord-261566-fn08b0y2	195	6	and	and	CC
cord-261566-fn08b0y2	195	7	mucosal	mucosal	JJ
cord-261566-fn08b0y2	195	8	vaccines	vaccine	NNS
cord-261566-fn08b0y2	195	9	,	,	,
cord-261566-fn08b0y2	195	10	correlates	correlate	VBZ
cord-261566-fn08b0y2	195	11	and	and	CC
cord-261566-fn08b0y2	195	12	precise	precise	JJ
cord-261566-fn08b0y2	195	13	mechanism	mechanism	NN
cord-261566-fn08b0y2	195	14	of	of	IN
cord-261566-fn08b0y2	195	15	their	-PRON-	PRP$
cord-261566-fn08b0y2	195	16	efficacy	efficacy	NN
cord-261566-fn08b0y2	195	17	remain	remain	VBP
cord-261566-fn08b0y2	195	18	poorly	poorly	RB
cord-261566-fn08b0y2	195	19	defined	define	VBN
cord-261566-fn08b0y2	195	20	.	.	.
cord-261566-fn08b0y2	196	1	Most	Most	JJS
cord-261566-fn08b0y2	196	2	of	of	IN
cord-261566-fn08b0y2	196	3	the	the	DT
cord-261566-fn08b0y2	196	4	licensed	licensed	JJ
cord-261566-fn08b0y2	196	5	vaccines	vaccine	NNS
cord-261566-fn08b0y2	196	6	rely	rely	VBP
cord-261566-fn08b0y2	196	7	on	on	IN
cord-261566-fn08b0y2	196	8	the	the	DT
cord-261566-fn08b0y2	196	9	measurement	measurement	NN
cord-261566-fn08b0y2	196	10	of	of	IN
cord-261566-fn08b0y2	196	11	a	a	DT
cord-261566-fn08b0y2	196	12	single	single	JJ
cord-261566-fn08b0y2	196	13	parameter	parameter	NN
cord-261566-fn08b0y2	196	14	that	that	WDT
cord-261566-fn08b0y2	196	15	is	be	VBZ
cord-261566-fn08b0y2	196	16	statistically	statistically	RB
cord-261566-fn08b0y2	196	17	correlated	correlate	VBN
cord-261566-fn08b0y2	196	18	with	with	IN
cord-261566-fn08b0y2	196	19	protection	protection	NN
cord-261566-fn08b0y2	196	20	afforded	afford	VBN
cord-261566-fn08b0y2	196	21	by	by	IN
cord-261566-fn08b0y2	196	22	the	the	DT
cord-261566-fn08b0y2	196	23	vaccine	vaccine	NN
cord-261566-fn08b0y2	196	24	.	.	.
cord-261566-fn08b0y2	197	1	There	there	EX
cord-261566-fn08b0y2	197	2	is	be	VBZ
cord-261566-fn08b0y2	197	3	no	no	DT
cord-261566-fn08b0y2	197	4	absolute	absolute	JJ
cord-261566-fn08b0y2	197	5	method	method	NN
cord-261566-fn08b0y2	197	6	of	of	IN
cord-261566-fn08b0y2	197	7	sampling	sampling	NN
cord-261566-fn08b0y2	197	8	,	,	,
cord-261566-fn08b0y2	197	9	and	and	CC
cord-261566-fn08b0y2	197	10	the	the	DT
cord-261566-fn08b0y2	197	11	choice	choice	NN
cord-261566-fn08b0y2	197	12	of	of	IN
cord-261566-fn08b0y2	197	13	sampling	sampling	NN
cord-261566-fn08b0y2	197	14	method	method	NN
cord-261566-fn08b0y2	197	15	varies	vary	VBZ
cord-261566-fn08b0y2	197	16	according	accord	VBG
cord-261566-fn08b0y2	197	17	to	to	IN
cord-261566-fn08b0y2	197	18	the	the	DT
cord-261566-fn08b0y2	197	19	parameter	parameter	NN
cord-261566-fn08b0y2	197	20	to	to	TO
cord-261566-fn08b0y2	197	21	be	be	VB
cord-261566-fn08b0y2	197	22	evaluated	evaluate	VBN
cord-261566-fn08b0y2	197	23	.	.	.
cord-261566-fn08b0y2	198	1	Conventionally	conventionally	RB
cord-261566-fn08b0y2	198	2	,	,	,
cord-261566-fn08b0y2	198	3	quantification	quantification	NN
cord-261566-fn08b0y2	198	4	and	and	CC
cord-261566-fn08b0y2	198	5	qualification	qualification	NN
cord-261566-fn08b0y2	198	6	of	of	IN
cord-261566-fn08b0y2	198	7	secreted	secrete	VBN
cord-261566-fn08b0y2	198	8	antibodies	antibody	NNS
cord-261566-fn08b0y2	198	9	is	be	VBZ
cord-261566-fn08b0y2	198	10	performed	perform	VBN
cord-261566-fn08b0y2	198	11	using	use	VBG
cord-261566-fn08b0y2	198	12	seroimmunoassays	seroimmunoassay	NNS
cord-261566-fn08b0y2	198	13	in	in	IN
cord-261566-fn08b0y2	198	14	body	body	NN
cord-261566-fn08b0y2	198	15	secretions	secretion	NNS
cord-261566-fn08b0y2	198	16	such	such	JJ
cord-261566-fn08b0y2	198	17	as	as	IN
cord-261566-fn08b0y2	198	18	saliva	saliva	NN
cord-261566-fn08b0y2	198	19	,	,	,
cord-261566-fn08b0y2	198	20	tears	tear	NNS
cord-261566-fn08b0y2	198	21	,	,	,
cord-261566-fn08b0y2	198	22	nasal	nasal	NN
cord-261566-fn08b0y2	198	23	,	,	,
cord-261566-fn08b0y2	198	24	blood	blood	NN
cord-261566-fn08b0y2	198	25	samples	sample	NNS
cord-261566-fn08b0y2	198	26	or	or	CC
cord-261566-fn08b0y2	198	27	genital	genital	JJ
cord-261566-fn08b0y2	198	28	secretions	secretion	NNS
cord-261566-fn08b0y2	198	29	,	,	,
cord-261566-fn08b0y2	198	30	and	and	CC
cord-261566-fn08b0y2	198	31	gut	gut	NN
cord-261566-fn08b0y2	198	32	or	or	CC
cord-261566-fn08b0y2	198	33	organ	organ	NN
cord-261566-fn08b0y2	198	34	lavages	lavage	NNS
cord-261566-fn08b0y2	198	35	.	.	.
cord-261566-fn08b0y2	199	1	95	95	CD
cord-261566-fn08b0y2	200	1	Cellular	cellular	JJ
cord-261566-fn08b0y2	200	2	correlates	correlate	NNS
cord-261566-fn08b0y2	200	3	of	of	IN
cord-261566-fn08b0y2	200	4	immunity	immunity	NN
cord-261566-fn08b0y2	200	5	are	be	VBP
cord-261566-fn08b0y2	200	6	analyzed	analyze	VBN
cord-261566-fn08b0y2	200	7	using	use	VBG
cord-261566-fn08b0y2	200	8	assays	assay	NNS
cord-261566-fn08b0y2	200	9	such	such	JJ
cord-261566-fn08b0y2	200	10	as	as	IN
cord-261566-fn08b0y2	200	11	enzyme	enzyme	NN
cord-261566-fn08b0y2	200	12	-	-	HYPH
cord-261566-fn08b0y2	200	13	linked	link	VBN
cord-261566-fn08b0y2	200	14	immunospot	immunospot	NN
cord-261566-fn08b0y2	200	15	assays	assay	NNS
cord-261566-fn08b0y2	200	16	(	(	-LRB-
cord-261566-fn08b0y2	200	17	ELISPOTs	elispot	NNS
cord-261566-fn08b0y2	200	18	)	)	-RRB-
cord-261566-fn08b0y2	200	19	,	,	,
cord-261566-fn08b0y2	200	20	reverse	reverse	NN
cord-261566-fn08b0y2	200	21	-	-	HYPH
cord-261566-fn08b0y2	200	22	transcriptase	transcriptase	NN
cord-261566-fn08b0y2	200	23	PCR	PCR	NNP
cord-261566-fn08b0y2	200	24	(	(	-LRB-
cord-261566-fn08b0y2	200	25	RT	RT	NNP
cord-261566-fn08b0y2	200	26	-	-	HYPH
cord-261566-fn08b0y2	200	27	PCR	PCR	NNP
cord-261566-fn08b0y2	200	28	)	)	-RRB-
cord-261566-fn08b0y2	200	29	or	or	CC
cord-261566-fn08b0y2	200	30	cell	cell	NN
cord-261566-fn08b0y2	200	31	-	-	HYPH
cord-261566-fn08b0y2	200	32	sorting	sort	VBG
cord-261566-fn08b0y2	200	33	techniques	technique	NNS
cord-261566-fn08b0y2	200	34	.	.	.
cord-261566-fn08b0y2	201	1	96	96	CD
cord-261566-fn08b0y2	202	1	A	a	DT
cord-261566-fn08b0y2	202	2	modern	modern	JJ
cord-261566-fn08b0y2	202	3	system	system	NN
cord-261566-fn08b0y2	202	4	biology	biology	NN
cord-261566-fn08b0y2	202	5	approach	approach	NN
cord-261566-fn08b0y2	202	6	can	can	MD
cord-261566-fn08b0y2	202	7	also	also	RB
cord-261566-fn08b0y2	202	8	be	be	VB
cord-261566-fn08b0y2	202	9	used	use	VBN
cord-261566-fn08b0y2	202	10	that	that	WDT
cord-261566-fn08b0y2	202	11	utilizes	utilize	VBZ
cord-261566-fn08b0y2	202	12	functional	functional	JJ
cord-261566-fn08b0y2	202	13	genomics	genomic	NNS
cord-261566-fn08b0y2	202	14	to	to	TO
cord-261566-fn08b0y2	202	15	identify	identify	VB
cord-261566-fn08b0y2	202	16	molecular	molecular	JJ
cord-261566-fn08b0y2	202	17	signatures	signature	NNS
cord-261566-fn08b0y2	202	18	that	that	WDT
cord-261566-fn08b0y2	202	19	correlate	correlate	VBP
cord-261566-fn08b0y2	202	20	well	well	RB
cord-261566-fn08b0y2	202	21	with	with	IN
cord-261566-fn08b0y2	202	22	traditional	traditional	JJ
cord-261566-fn08b0y2	202	23	biological	biological	JJ
cord-261566-fn08b0y2	202	24	markers	marker	NNS
cord-261566-fn08b0y2	202	25	for	for	IN
cord-261566-fn08b0y2	202	26	evaluating	evaluate	VBG
cord-261566-fn08b0y2	202	27	vaccine	vaccine	NN
cord-261566-fn08b0y2	202	28	efficacy	efficacy	NN
cord-261566-fn08b0y2	202	29	.	.	.
cord-261566-fn08b0y2	203	1	97	97	CD
cord-261566-fn08b0y2	203	2	Correlates	correlate	NNS
cord-261566-fn08b0y2	203	3	of	of	IN
cord-261566-fn08b0y2	203	4	protection	protection	NN
cord-261566-fn08b0y2	203	5	differ	differ	VBP
cord-261566-fn08b0y2	203	6	greatly	greatly	RB
cord-261566-fn08b0y2	203	7	based	base	VBN
cord-261566-fn08b0y2	203	8	on	on	IN
cord-261566-fn08b0y2	203	9	whether	whether	IN
cord-261566-fn08b0y2	203	10	the	the	DT
cord-261566-fn08b0y2	203	11	objective	objective	NN
cord-261566-fn08b0y2	203	12	of	of	IN
cord-261566-fn08b0y2	203	13	vaccination	vaccination	NN
cord-261566-fn08b0y2	203	14	is	be	VBZ
cord-261566-fn08b0y2	203	15	to	to	TO
cord-261566-fn08b0y2	203	16	prevent	prevent	VB
cord-261566-fn08b0y2	203	17	a	a	DT
cord-261566-fn08b0y2	203	18	mucosal	mucosal	NN
cord-261566-fn08b0y2	203	19	or	or	CC
cord-261566-fn08b0y2	203	20	a	a	DT
cord-261566-fn08b0y2	203	21	systemic	systemic	JJ
cord-261566-fn08b0y2	203	22	infection	infection	NN
cord-261566-fn08b0y2	203	23	.	.	.
cord-261566-fn08b0y2	204	1	96	96	CD
cord-261566-fn08b0y2	205	1	Several	several	JJ
cord-261566-fn08b0y2	205	2	animal	animal	NN
cord-261566-fn08b0y2	205	3	models	model	NNS
cord-261566-fn08b0y2	205	4	including	include	VBG
cord-261566-fn08b0y2	205	5	mice	mouse	NNS
cord-261566-fn08b0y2	205	6	,	,	,
cord-261566-fn08b0y2	205	7	ferrets	ferret	NNS
cord-261566-fn08b0y2	205	8	,	,	,
cord-261566-fn08b0y2	205	9	macaques	macaque	NNS
cord-261566-fn08b0y2	205	10	,	,	,
cord-261566-fn08b0y2	205	11	hamsters	hamster	NNS
cord-261566-fn08b0y2	205	12	,	,	,
cord-261566-fn08b0y2	205	13	and	and	CC
cord-261566-fn08b0y2	205	14	non	non	JJ
cord-261566-fn08b0y2	205	15	-	-	JJ
cord-261566-fn08b0y2	205	16	human	human	JJ
cord-261566-fn08b0y2	205	17	primates	primate	NNS
cord-261566-fn08b0y2	205	18	have	have	VBP
cord-261566-fn08b0y2	205	19	been	be	VBN
cord-261566-fn08b0y2	205	20	used	use	VBN
cord-261566-fn08b0y2	205	21	for	for	IN
cord-261566-fn08b0y2	205	22	evaluating	evaluate	VBG
cord-261566-fn08b0y2	205	23	safety	safety	NN
cord-261566-fn08b0y2	205	24	and	and	CC
cord-261566-fn08b0y2	205	25	efficacy	efficacy	NN
cord-261566-fn08b0y2	205	26	of	of	IN
cord-261566-fn08b0y2	205	27	SARS	SARS	NNP
cord-261566-fn08b0y2	205	28	-	-	HYPH
cord-261566-fn08b0y2	205	29	CoV	CoV	NNP
cord-261566-fn08b0y2	205	30	and	and	CC
cord-261566-fn08b0y2	205	31	MERS	MERS	NNP
cord-261566-fn08b0y2	205	32	-	-	HYPH
cord-261566-fn08b0y2	205	33	CoV	CoV	NNP
cord-261566-fn08b0y2	205	34	vaccines	vaccine	NNS
cord-261566-fn08b0y2	205	35	.	.	.
cord-261566-fn08b0y2	206	1	53	53	CD
cord-261566-fn08b0y2	206	2	,	,	,
cord-261566-fn08b0y2	206	3	[	[	-LRB-
cord-261566-fn08b0y2	206	4	98	98	CD
cord-261566-fn08b0y2	206	5	]	]	-RRB-
cord-261566-fn08b0y2	206	6	[	[	-LRB-
cord-261566-fn08b0y2	206	7	99	99	CD
cord-261566-fn08b0y2	206	8	]	]	-RRB-
cord-261566-fn08b0y2	206	9	[	[	-LRB-
cord-261566-fn08b0y2	206	10	100	100	CD
cord-261566-fn08b0y2	206	11	]	]	-RRB-
cord-261566-fn08b0y2	206	12	[	[	-LRB-
cord-261566-fn08b0y2	206	13	101	101	CD
cord-261566-fn08b0y2	206	14	]	]	-RRB-
cord-261566-fn08b0y2	206	15	[	[	-LRB-
cord-261566-fn08b0y2	206	16	102	102	CD
cord-261566-fn08b0y2	206	17	]	]	-RRB-
cord-261566-fn08b0y2	206	18	Ferrets	ferret	NNS
cord-261566-fn08b0y2	206	19	are	be	VBP
cord-261566-fn08b0y2	206	20	a	a	DT
cord-261566-fn08b0y2	206	21	suitable	suitable	JJ
cord-261566-fn08b0y2	206	22	animal	animal	NN
cord-261566-fn08b0y2	206	23	model	model	NN
cord-261566-fn08b0y2	206	24	for	for	IN
cord-261566-fn08b0y2	206	25	SARS	SARS	NNP
cord-261566-fn08b0y2	206	26	-	-	HYPH
cord-261566-fn08b0y2	206	27	CoV	CoV	NNP
cord-261566-fn08b0y2	206	28	vaccine	vaccine	NN
cord-261566-fn08b0y2	206	29	evaluation	evaluation	NN
cord-261566-fn08b0y2	206	30	as	as	IN
cord-261566-fn08b0y2	206	31	they	-PRON-	PRP
cord-261566-fn08b0y2	206	32	support	support	VBP
cord-261566-fn08b0y2	206	33	viral	viral	JJ
cord-261566-fn08b0y2	206	34	replication	replication	NN
cord-261566-fn08b0y2	206	35	in	in	IN
cord-261566-fn08b0y2	206	36	the	the	DT
cord-261566-fn08b0y2	206	37	respiratory	respiratory	JJ
cord-261566-fn08b0y2	206	38	tract	tract	NN
cord-261566-fn08b0y2	206	39	,	,	,
cord-261566-fn08b0y2	206	40	develop	develop	VB
cord-261566-fn08b0y2	206	41	similar	similar	JJ
cord-261566-fn08b0y2	206	42	disease	disease	NN
cord-261566-fn08b0y2	206	43	symptoms	symptom	NNS
cord-261566-fn08b0y2	206	44	,	,	,
cord-261566-fn08b0y2	206	45	and	and	CC
cord-261566-fn08b0y2	206	46	display	display	VB
cord-261566-fn08b0y2	206	47	severe	severe	JJ
cord-261566-fn08b0y2	206	48	lung	lung	NN
cord-261566-fn08b0y2	206	49	pathology	pathology	NN
cord-261566-fn08b0y2	206	50	.	.	.
cord-261566-fn08b0y2	207	1	103	103	CD
cord-261566-fn08b0y2	207	2	,	,	,
cord-261566-fn08b0y2	207	3	104	104	CD
cord-261566-fn08b0y2	207	4	Smaller	small	JJR
cord-261566-fn08b0y2	207	5	animal	animal	NN
cord-261566-fn08b0y2	207	6	models	model	NNS
cord-261566-fn08b0y2	207	7	like	like	IN
cord-261566-fn08b0y2	207	8	rabbits	rabbit	NNS
cord-261566-fn08b0y2	207	9	and	and	CC
cord-261566-fn08b0y2	207	10	mice	mouse	NNS
cord-261566-fn08b0y2	207	11	are	be	VBP
cord-261566-fn08b0y2	207	12	a	a	DT
cord-261566-fn08b0y2	207	13	preferred	preferred	JJ
cord-261566-fn08b0y2	207	14	choice	choice	NN
cord-261566-fn08b0y2	207	15	for	for	IN
cord-261566-fn08b0y2	207	16	vaccine	vaccine	NN
cord-261566-fn08b0y2	207	17	evaluation	evaluation	NN
cord-261566-fn08b0y2	207	18	in	in	IN
cord-261566-fn08b0y2	207	19	animals	animal	NNS
cord-261566-fn08b0y2	207	20	because	because	IN
cord-261566-fn08b0y2	207	21	of	of	IN
cord-261566-fn08b0y2	207	22	inexpensive	inexpensive	JJ
cord-261566-fn08b0y2	207	23	maintenance	maintenance	NN
cord-261566-fn08b0y2	207	24	,	,	,
cord-261566-fn08b0y2	207	25	ease	ease	NN
cord-261566-fn08b0y2	207	26	of	of	IN
cord-261566-fn08b0y2	207	27	genetic	genetic	JJ
cord-261566-fn08b0y2	207	28	manipulation	manipulation	NN
cord-261566-fn08b0y2	207	29	,	,	,
cord-261566-fn08b0y2	207	30	and	and	CC
cord-261566-fn08b0y2	207	31	standardized	standardized	JJ
cord-261566-fn08b0y2	207	32	methods	method	NNS
cord-261566-fn08b0y2	207	33	of	of	IN
cord-261566-fn08b0y2	207	34	testing	testing	NN
cord-261566-fn08b0y2	207	35	.	.	.
cord-261566-fn08b0y2	208	1	Wild	wild	JJ
cord-261566-fn08b0y2	208	2	type	type	NN
cord-261566-fn08b0y2	208	3	mice	mouse	NNS
cord-261566-fn08b0y2	208	4	are	be	VBP
cord-261566-fn08b0y2	208	5	nonpermissive	nonpermissive	JJ
cord-261566-fn08b0y2	208	6	to	to	IN
cord-261566-fn08b0y2	208	7	SARS	SARS	NNP
cord-261566-fn08b0y2	208	8	-	-	HYPH
cord-261566-fn08b0y2	208	9	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	208	10	viral	viral	JJ
cord-261566-fn08b0y2	208	11	replication	replication	NN
cord-261566-fn08b0y2	208	12	.	.	.
cord-261566-fn08b0y2	209	1	A	a	DT
cord-261566-fn08b0y2	209	2	transgenic	transgenic	JJ
cord-261566-fn08b0y2	209	3	mice	mice	NN
cord-261566-fn08b0y2	209	4	model	model	NN
cord-261566-fn08b0y2	209	5	expressing	express	VBG
cord-261566-fn08b0y2	209	6	hACE2	hACE2	NNP
cord-261566-fn08b0y2	209	7	has	have	VBZ
cord-261566-fn08b0y2	209	8	recently	recently	RB
cord-261566-fn08b0y2	209	9	been	be	VBN
cord-261566-fn08b0y2	209	10	developed	develop	VBN
cord-261566-fn08b0y2	209	11	by	by	IN
cord-261566-fn08b0y2	209	12	genetic	genetic	JJ
cord-261566-fn08b0y2	209	13	manipulation	manipulation	NN
cord-261566-fn08b0y2	209	14	to	to	TO
cord-261566-fn08b0y2	209	15	make	make	VB
cord-261566-fn08b0y2	209	16	the	the	DT
cord-261566-fn08b0y2	209	17	mice	mouse	NNS
cord-261566-fn08b0y2	209	18	susceptible	susceptible	JJ
cord-261566-fn08b0y2	209	19	to	to	IN
cord-261566-fn08b0y2	209	20	SARS	SARS	NNP
cord-261566-fn08b0y2	209	21	-	-	HYPH
cord-261566-fn08b0y2	209	22	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	209	23	infection	infection	NN
cord-261566-fn08b0y2	209	24	.	.	.
cord-261566-fn08b0y2	210	1	105	105	CD
cord-261566-fn08b0y2	211	1	This	this	DT
cord-261566-fn08b0y2	211	2	mice	mice	NN
cord-261566-fn08b0y2	211	3	model	model	NN
cord-261566-fn08b0y2	211	4	mirrors	mirror	VBZ
cord-261566-fn08b0y2	211	5	the	the	DT
cord-261566-fn08b0y2	211	6	pathological	pathological	JJ
cord-261566-fn08b0y2	211	7	features	feature	NNS
cord-261566-fn08b0y2	211	8	of	of	IN
cord-261566-fn08b0y2	211	9	SARS	SARS	NNP
cord-261566-fn08b0y2	211	10	-	-	HYPH
cord-261566-fn08b0y2	211	11	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	211	12	infection	infection	NN
cord-261566-fn08b0y2	211	13	in	in	IN
cord-261566-fn08b0y2	211	14	human	human	JJ
cord-261566-fn08b0y2	211	15	patients	patient	NNS
cord-261566-fn08b0y2	211	16	albeit	albeit	IN
cord-261566-fn08b0y2	211	17	at	at	IN
cord-261566-fn08b0y2	211	18	a	a	DT
cord-261566-fn08b0y2	211	19	moderate	moderate	JJ
cord-261566-fn08b0y2	211	20	level	level	NN
cord-261566-fn08b0y2	211	21	as	as	IN
cord-261566-fn08b0y2	211	22	compared	compare	VBN
cord-261566-fn08b0y2	211	23	to	to	IN
cord-261566-fn08b0y2	211	24	SARS	SARS	NNP
cord-261566-fn08b0y2	211	25	-	-	HYPH
cord-261566-fn08b0y2	211	26	CoV.	CoV.	NNP
cord-261566-fn08b0y2	212	1	Moreover	moreover	RB
cord-261566-fn08b0y2	212	2	,	,	,
cord-261566-fn08b0y2	212	3	a	a	DT
cord-261566-fn08b0y2	212	4	young	young	JJ
cord-261566-fn08b0y2	212	5	animal	animal	NN
cord-261566-fn08b0y2	212	6	/	/	SYM
cord-261566-fn08b0y2	212	7	mice	mice	NN
cord-261566-fn08b0y2	212	8	model	model	NN
cord-261566-fn08b0y2	212	9	can	can	MD
cord-261566-fn08b0y2	212	10	effectively	effectively	RB
cord-261566-fn08b0y2	212	11	exhibit	exhibit	VB
cord-261566-fn08b0y2	212	12	excellent	excellent	JJ
cord-261566-fn08b0y2	212	13	neutralizing	neutralize	VBG
cord-261566-fn08b0y2	212	14	efficiency	efficiency	NN
cord-261566-fn08b0y2	212	15	induced	induce	VBN
cord-261566-fn08b0y2	212	16	by	by	IN
cord-261566-fn08b0y2	212	17	a	a	DT
cord-261566-fn08b0y2	212	18	vaccine	vaccine	NN
cord-261566-fn08b0y2	212	19	candidate	candidate	NN
cord-261566-fn08b0y2	213	1	but	but	CC
cord-261566-fn08b0y2	213	2	it	-PRON-	PRP
cord-261566-fn08b0y2	213	3	can	can	MD
cord-261566-fn08b0y2	213	4	not	not	RB
cord-261566-fn08b0y2	213	5	effectively	effectively	RB
cord-261566-fn08b0y2	213	6	mimic	mimic	VB
cord-261566-fn08b0y2	213	7	the	the	DT
cord-261566-fn08b0y2	213	8	clinical	clinical	JJ
cord-261566-fn08b0y2	213	9	manifestations	manifestation	NNS
cord-261566-fn08b0y2	213	10	of	of	IN
cord-261566-fn08b0y2	213	11	COVID-19	covid-19	CD
cord-261566-fn08b0y2	213	12	in	in	IN
cord-261566-fn08b0y2	213	13	an	an	DT
cord-261566-fn08b0y2	213	14	elderly	elderly	JJ
cord-261566-fn08b0y2	213	15	population	population	NN
cord-261566-fn08b0y2	213	16	.	.	.
cord-261566-fn08b0y2	214	1	Hence	hence	RB
cord-261566-fn08b0y2	214	2	,	,	,
cord-261566-fn08b0y2	214	3	robust	robust	JJ
cord-261566-fn08b0y2	214	4	lethalchallenged	lethalchallenged	JJ
cord-261566-fn08b0y2	214	5	mice	mice	NN
cord-261566-fn08b0y2	214	6	models	model	NNS
cord-261566-fn08b0y2	214	7	using	use	VBG
cord-261566-fn08b0y2	214	8	senescent	senescent	JJ
cord-261566-fn08b0y2	214	9	mice	mouse	NNS
cord-261566-fn08b0y2	214	10	that	that	WDT
cord-261566-fn08b0y2	214	11	can	can	MD
cord-261566-fn08b0y2	214	12	recapitulate	recapitulate	VB
cord-261566-fn08b0y2	214	13	the	the	DT
cord-261566-fn08b0y2	214	14	clinical	clinical	JJ
cord-261566-fn08b0y2	214	15	disease	disease	NN
cord-261566-fn08b0y2	214	16	in	in	IN
cord-261566-fn08b0y2	214	17	the	the	DT
cord-261566-fn08b0y2	214	18	aged	aged	JJ
cord-261566-fn08b0y2	214	19	human	human	JJ
cord-261566-fn08b0y2	214	20	population	population	NN
cord-261566-fn08b0y2	214	21	are	be	VBP
cord-261566-fn08b0y2	214	22	needed	need	VBN
cord-261566-fn08b0y2	214	23	to	to	TO
cord-261566-fn08b0y2	214	24	be	be	VB
cord-261566-fn08b0y2	214	25	developed	develop	VBN
cord-261566-fn08b0y2	214	26	for	for	IN
cord-261566-fn08b0y2	214	27	assessing	assess	VBG
cord-261566-fn08b0y2	214	28	the	the	DT
cord-261566-fn08b0y2	214	29	efficacy	efficacy	NN
cord-261566-fn08b0y2	214	30	of	of	IN
cord-261566-fn08b0y2	214	31	a	a	DT
cord-261566-fn08b0y2	214	32	COVID-19	covid-19	JJ
cord-261566-fn08b0y2	214	33	vaccine	vaccine	NN
cord-261566-fn08b0y2	214	34	candidate	candidate	NN
cord-261566-fn08b0y2	214	35	.	.	.
cord-261566-fn08b0y2	215	1	Following	follow	VBG
cord-261566-fn08b0y2	215	2	animal	animal	NN
cord-261566-fn08b0y2	215	3	modelbased	modelbase	VBD
cord-261566-fn08b0y2	215	4	preclinical	preclinical	JJ
cord-261566-fn08b0y2	215	5	studies	study	NNS
cord-261566-fn08b0y2	215	6	,	,	,
cord-261566-fn08b0y2	215	7	good	good	JJ
cord-261566-fn08b0y2	215	8	manufacturing	manufacturing	NN
cord-261566-fn08b0y2	215	9	practices	practice	NNS
cord-261566-fn08b0y2	215	10	are	be	VBP
cord-261566-fn08b0y2	215	11	employed	employ	VBN
cord-261566-fn08b0y2	215	12	for	for	IN
cord-261566-fn08b0y2	215	13	the	the	DT
cord-261566-fn08b0y2	215	14	scale	scale	NN
cord-261566-fn08b0y2	215	15	-	-	HYPH
cord-261566-fn08b0y2	215	16	up	up	NN
cord-261566-fn08b0y2	215	17	of	of	IN
cord-261566-fn08b0y2	215	18	the	the	DT
cord-261566-fn08b0y2	215	19	vaccine	vaccine	NN
cord-261566-fn08b0y2	215	20	production	production	NN
cord-261566-fn08b0y2	215	21	.	.	.
cord-261566-fn08b0y2	216	1	Currently	currently	RB
cord-261566-fn08b0y2	216	2	,	,	,
cord-261566-fn08b0y2	216	3	mucosal	mucosal	JJ
cord-261566-fn08b0y2	216	4	vaccines	vaccine	NNS
cord-261566-fn08b0y2	216	5	form	form	VBP
cord-261566-fn08b0y2	216	6	a	a	DT
cord-261566-fn08b0y2	216	7	small	small	JJ
cord-261566-fn08b0y2	216	8	proportion	proportion	NN
cord-261566-fn08b0y2	216	9	of	of	IN
cord-261566-fn08b0y2	216	10	licensed	licensed	JJ
cord-261566-fn08b0y2	216	11	vaccines	vaccine	NNS
cord-261566-fn08b0y2	216	12	for	for	IN
cord-261566-fn08b0y2	216	13	humans	human	NNS
cord-261566-fn08b0y2	216	14	.	.	.
cord-261566-fn08b0y2	217	1	Limited	limited	JJ
cord-261566-fn08b0y2	217	2	choice	choice	NN
cord-261566-fn08b0y2	217	3	of	of	IN
cord-261566-fn08b0y2	217	4	adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	217	5	for	for	IN
cord-261566-fn08b0y2	217	6	human	human	JJ
cord-261566-fn08b0y2	217	7	mucosal	mucosal	JJ
cord-261566-fn08b0y2	217	8	vaccines	vaccine	NNS
cord-261566-fn08b0y2	217	9	,	,	,
cord-261566-fn08b0y2	217	10	immunotolerance	immunotolerance	NN
cord-261566-fn08b0y2	217	11	,	,	,
cord-261566-fn08b0y2	217	12	and	and	CC
cord-261566-fn08b0y2	217	13	differential	differential	JJ
cord-261566-fn08b0y2	217	14	degree	degree	NN
cord-261566-fn08b0y2	217	15	of	of	IN
cord-261566-fn08b0y2	217	16	vaccine	vaccine	NN
cord-261566-fn08b0y2	217	17	-	-	HYPH
cord-261566-fn08b0y2	217	18	induced	induce	VBN
cord-261566-fn08b0y2	217	19	immune	immune	JJ
cord-261566-fn08b0y2	217	20	response	response	NN
cord-261566-fn08b0y2	217	21	in	in	IN
cord-261566-fn08b0y2	217	22	different	different	JJ
cord-261566-fn08b0y2	217	23	populations	population	NNS
cord-261566-fn08b0y2	217	24	are	be	VBP
cord-261566-fn08b0y2	217	25	some	some	DT
cord-261566-fn08b0y2	217	26	of	of	IN
cord-261566-fn08b0y2	217	27	the	the	DT
cord-261566-fn08b0y2	217	28	impediments	impediment	NNS
cord-261566-fn08b0y2	217	29	associated	associate	VBN
cord-261566-fn08b0y2	217	30	with	with	IN
cord-261566-fn08b0y2	217	31	the	the	DT
cord-261566-fn08b0y2	217	32	development	development	NN
cord-261566-fn08b0y2	217	33	of	of	IN
cord-261566-fn08b0y2	217	34	mucosal	mucosal	JJ
cord-261566-fn08b0y2	217	35	vaccines	vaccine	NNS
cord-261566-fn08b0y2	217	36	.	.	.
cord-261566-fn08b0y2	218	1	Efficacies	efficacy	NNS
cord-261566-fn08b0y2	218	2	of	of	IN
cord-261566-fn08b0y2	218	3	different	different	JJ
cord-261566-fn08b0y2	218	4	mucosal	mucosal	JJ
cord-261566-fn08b0y2	218	5	vaccines	vaccine	NNS
cord-261566-fn08b0y2	218	6	depend	depend	VBP
cord-261566-fn08b0y2	218	7	on	on	IN
cord-261566-fn08b0y2	218	8	myriad	myriad	NNS
cord-261566-fn08b0y2	218	9	of	of	IN
cord-261566-fn08b0y2	218	10	factors	factor	NNS
cord-261566-fn08b0y2	218	11	such	such	JJ
cord-261566-fn08b0y2	218	12	as	as	IN
cord-261566-fn08b0y2	218	13	age	age	NN
cord-261566-fn08b0y2	218	14	,	,	,
cord-261566-fn08b0y2	218	15	environment	environment	NN
cord-261566-fn08b0y2	218	16	,	,	,
cord-261566-fn08b0y2	218	17	host	host	NN
cord-261566-fn08b0y2	218	18	genetics	genetics	NN
cord-261566-fn08b0y2	218	19	,	,	,
cord-261566-fn08b0y2	218	20	the	the	DT
cord-261566-fn08b0y2	218	21	microbiome	microbiome	NN
cord-261566-fn08b0y2	218	22	of	of	IN
cord-261566-fn08b0y2	218	23	the	the	DT
cord-261566-fn08b0y2	218	24	recipient	recipient	NN
cord-261566-fn08b0y2	218	25	,	,	,
cord-261566-fn08b0y2	218	26	and	and	CC
cord-261566-fn08b0y2	218	27	the	the	DT
cord-261566-fn08b0y2	218	28	regimen	regimen	NN
cord-261566-fn08b0y2	218	29	of	of	IN
cord-261566-fn08b0y2	218	30	immunization	immunization	NN
cord-261566-fn08b0y2	218	31	.	.	.
cord-261566-fn08b0y2	219	1	It	-PRON-	PRP
cord-261566-fn08b0y2	219	2	ranges	range	VBZ
cord-261566-fn08b0y2	219	3	from	from	IN
cord-261566-fn08b0y2	219	4	70	70	CD
cord-261566-fn08b0y2	219	5	%	%	NN
cord-261566-fn08b0y2	219	6	to	to	TO
cord-261566-fn08b0y2	219	7	90	90	CD
cord-261566-fn08b0y2	219	8	%	%	NN
cord-261566-fn08b0y2	219	9	for	for	IN
cord-261566-fn08b0y2	219	10	rotavirus	rotavirus	JJ
cord-261566-fn08b0y2	219	11	vaccines	vaccine	NNS
cord-261566-fn08b0y2	219	12	to	to	IN
cord-261566-fn08b0y2	219	13	85%-to	85%-to	CD
cord-261566-fn08b0y2	219	14	90	90	CD
cord-261566-fn08b0y2	219	15	%	%	NN
cord-261566-fn08b0y2	219	16	for	for	IN
cord-261566-fn08b0y2	219	17	oral	oral	JJ
cord-261566-fn08b0y2	219	18	vaccines	vaccine	NNS
cord-261566-fn08b0y2	219	19	against	against	IN
cord-261566-fn08b0y2	219	20	influenza	influenza	NN
cord-261566-fn08b0y2	219	21	and	and	CC
cord-261566-fn08b0y2	219	22	polio	polio	NN
cord-261566-fn08b0y2	219	23	viruses	virus	NNS
cord-261566-fn08b0y2	219	24	.	.	.
cord-261566-fn08b0y2	220	1	22	22	CD
cord-261566-fn08b0y2	220	2	Cholera	cholera	NN
cord-261566-fn08b0y2	220	3	,	,	,
cord-261566-fn08b0y2	220	4	polio	polio	NN
cord-261566-fn08b0y2	220	5	,	,	,
cord-261566-fn08b0y2	220	6	and	and	CC
cord-261566-fn08b0y2	220	7	rotavirus	rotavirus	JJ
cord-261566-fn08b0y2	220	8	oral	oral	JJ
cord-261566-fn08b0y2	220	9	vaccines	vaccine	NNS
cord-261566-fn08b0y2	220	10	are	be	VBP
cord-261566-fn08b0y2	220	11	found	find	VBN
cord-261566-fn08b0y2	220	12	to	to	TO
cord-261566-fn08b0y2	220	13	be	be	VB
cord-261566-fn08b0y2	220	14	less	less	RBR
cord-261566-fn08b0y2	220	15	efficacious	efficacious	JJ
cord-261566-fn08b0y2	220	16	in	in	IN
cord-261566-fn08b0y2	220	17	developing	develop	VBG
cord-261566-fn08b0y2	220	18	countries	country	NNS
cord-261566-fn08b0y2	220	19	.	.	.
cord-261566-fn08b0y2	221	1	This	this	DT
cord-261566-fn08b0y2	221	2	weak	weak	JJ
cord-261566-fn08b0y2	221	3	induction	induction	NN
cord-261566-fn08b0y2	221	4	of	of	IN
cord-261566-fn08b0y2	221	5	immune	immune	JJ
cord-261566-fn08b0y2	221	6	response	response	NN
cord-261566-fn08b0y2	221	7	can	can	MD
cord-261566-fn08b0y2	221	8	be	be	VB
cord-261566-fn08b0y2	221	9	attributed	attribute	VBN
cord-261566-fn08b0y2	221	10	to	to	IN
cord-261566-fn08b0y2	221	11	nutritional	nutritional	JJ
cord-261566-fn08b0y2	221	12	deficiencies	deficiency	NNS
cord-261566-fn08b0y2	221	13	such	such	JJ
cord-261566-fn08b0y2	221	14	as	as	IN
cord-261566-fn08b0y2	221	15	vitamin	vitamin	NN
cord-261566-fn08b0y2	221	16	A	a	NN
cord-261566-fn08b0y2	221	17	or	or	CC
cord-261566-fn08b0y2	221	18	zinc	zinc	NN
cord-261566-fn08b0y2	221	19	,	,	,
cord-261566-fn08b0y2	221	20	concomitant	concomitant	JJ
cord-261566-fn08b0y2	221	21	bacterial	bacterial	JJ
cord-261566-fn08b0y2	221	22	,	,	,
cord-261566-fn08b0y2	221	23	helminth	helminth	NN
cord-261566-fn08b0y2	221	24	,	,	,
cord-261566-fn08b0y2	221	25	or	or	CC
cord-261566-fn08b0y2	221	26	viral	viral	JJ
cord-261566-fn08b0y2	221	27	infections	infection	NNS
cord-261566-fn08b0y2	221	28	,	,	,
cord-261566-fn08b0y2	221	29	and	and	CC
cord-261566-fn08b0y2	221	30	the	the	DT
cord-261566-fn08b0y2	221	31	presence	presence	NN
cord-261566-fn08b0y2	221	32	of	of	IN
cord-261566-fn08b0y2	221	33	high	high	JJ
cord-261566-fn08b0y2	221	34	levels	level	NNS
cord-261566-fn08b0y2	221	35	of	of	IN
cord-261566-fn08b0y2	221	36	maternal	maternal	JJ
cord-261566-fn08b0y2	221	37	antibodies	antibody	NNS
cord-261566-fn08b0y2	221	38	in	in	IN
cord-261566-fn08b0y2	221	39	the	the	DT
cord-261566-fn08b0y2	221	40	breast	breast	NN
cord-261566-fn08b0y2	221	41	milk	milk	NN
cord-261566-fn08b0y2	221	42	.	.	.
cord-261566-fn08b0y2	222	1	106	106	CD
cord-261566-fn08b0y2	222	2	,	,	,
cord-261566-fn08b0y2	222	3	107	107	CD
cord-261566-fn08b0y2	222	4	Intranasal	Intranasal	NNP
cord-261566-fn08b0y2	222	5	immunization	immunization	NN
cord-261566-fn08b0y2	222	6	using	use	VBG
cord-261566-fn08b0y2	222	7	live	live	RB
cord-261566-fn08b0y2	222	8	attenuated	attenuated	JJ
cord-261566-fn08b0y2	222	9	or	or	CC
cord-261566-fn08b0y2	222	10	live	live	JJ
cord-261566-fn08b0y2	222	11	vectors	vector	NNS
cord-261566-fn08b0y2	222	12	is	be	VBZ
cord-261566-fn08b0y2	222	13	also	also	RB
cord-261566-fn08b0y2	222	14	associated	associate	VBN
cord-261566-fn08b0y2	222	15	with	with	IN
cord-261566-fn08b0y2	222	16	the	the	DT
cord-261566-fn08b0y2	222	17	risk	risk	NN
cord-261566-fn08b0y2	222	18	of	of	IN
cord-261566-fn08b0y2	222	19	the	the	DT
cord-261566-fn08b0y2	222	20	harmful	harmful	JJ
cord-261566-fn08b0y2	222	21	antigens	antigen	NNS
cord-261566-fn08b0y2	222	22	and	and	CC
cord-261566-fn08b0y2	222	23	adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	222	24	(	(	-LRB-
cord-261566-fn08b0y2	222	25	such	such	JJ
cord-261566-fn08b0y2	222	26	as	as	IN
cord-261566-fn08b0y2	222	27	CT	CT	NNP
cord-261566-fn08b0y2	222	28	and	and	CC
cord-261566-fn08b0y2	222	29	LT	LT	NNP
cord-261566-fn08b0y2	222	30	)	)	-RRB-
cord-261566-fn08b0y2	222	31	accessing	access	VBG
cord-261566-fn08b0y2	222	32	the	the	DT
cord-261566-fn08b0y2	222	33	central	central	JJ
cord-261566-fn08b0y2	222	34	nervous	nervous	JJ
cord-261566-fn08b0y2	222	35	system	system	NN
cord-261566-fn08b0y2	222	36	through	through	IN
cord-261566-fn08b0y2	222	37	the	the	DT
cord-261566-fn08b0y2	222	38	cribiform	cribiform	NN
cord-261566-fn08b0y2	222	39	plate	plate	NN
cord-261566-fn08b0y2	222	40	.	.	.
cord-261566-fn08b0y2	223	1	108	108	CD
cord-261566-fn08b0y2	224	1	A	a	DT
cord-261566-fn08b0y2	224	2	number	number	NN
cord-261566-fn08b0y2	224	3	of	of	IN
cord-261566-fn08b0y2	224	4	infectious	infectious	JJ
cord-261566-fn08b0y2	224	5	diseases	disease	NNS
cord-261566-fn08b0y2	224	6	have	have	VBP
cord-261566-fn08b0y2	224	7	been	be	VBN
cord-261566-fn08b0y2	224	8	successfully	successfully	RB
cord-261566-fn08b0y2	224	9	controlled	control	VBN
cord-261566-fn08b0y2	224	10	with	with	IN
cord-261566-fn08b0y2	224	11	the	the	DT
cord-261566-fn08b0y2	224	12	use	use	NN
cord-261566-fn08b0y2	224	13	of	of	IN
cord-261566-fn08b0y2	224	14	parenterally	parenterally	NN
cord-261566-fn08b0y2	224	15	administered	administer	VBN
cord-261566-fn08b0y2	224	16	vaccine	vaccine	NN
cord-261566-fn08b0y2	224	17	that	that	WDT
cord-261566-fn08b0y2	224	18	may	may	MD
cord-261566-fn08b0y2	224	19	or	or	CC
cord-261566-fn08b0y2	224	20	may	may	MD
cord-261566-fn08b0y2	224	21	not	not	RB
cord-261566-fn08b0y2	224	22	lead	lead	VB
cord-261566-fn08b0y2	224	23	to	to	IN
cord-261566-fn08b0y2	224	24	the	the	DT
cord-261566-fn08b0y2	224	25	induction	induction	NN
cord-261566-fn08b0y2	224	26	of	of	IN
cord-261566-fn08b0y2	224	27	mucosal	mucosal	JJ
cord-261566-fn08b0y2	224	28	immune	immune	JJ
cord-261566-fn08b0y2	224	29	response	response	NN
cord-261566-fn08b0y2	224	30	.	.	.
cord-261566-fn08b0y2	225	1	Administration	administration	NN
cord-261566-fn08b0y2	225	2	of	of	IN
cord-261566-fn08b0y2	225	3	the	the	DT
cord-261566-fn08b0y2	225	4	vaccine	vaccine	NN
cord-261566-fn08b0y2	225	5	through	through	IN
cord-261566-fn08b0y2	225	6	systemic	systemic	JJ
cord-261566-fn08b0y2	225	7	circulation	circulation	NN
cord-261566-fn08b0y2	225	8	might	may	MD
cord-261566-fn08b0y2	225	9	not	not	RB
cord-261566-fn08b0y2	225	10	necessarily	necessarily	RB
cord-261566-fn08b0y2	225	11	recapitulate	recapitulate	VB
cord-261566-fn08b0y2	225	12	the	the	DT
cord-261566-fn08b0y2	225	13	immune	immune	JJ
cord-261566-fn08b0y2	225	14	response	response	NN
cord-261566-fn08b0y2	225	15	generated	generate	VBN
cord-261566-fn08b0y2	225	16	by	by	IN
cord-261566-fn08b0y2	225	17	mucosal	mucosal	JJ
cord-261566-fn08b0y2	225	18	administration	administration	NN
cord-261566-fn08b0y2	225	19	but	but	CC
cord-261566-fn08b0y2	225	20	is	be	VBZ
cord-261566-fn08b0y2	225	21	adequate	adequate	JJ
cord-261566-fn08b0y2	225	22	for	for	IN
cord-261566-fn08b0y2	225	23	evoking	evoke	VBG
cord-261566-fn08b0y2	225	24	immune	immune	JJ
cord-261566-fn08b0y2	225	25	response	response	NN
cord-261566-fn08b0y2	225	26	against	against	IN
cord-261566-fn08b0y2	225	27	mucosal	mucosal	JJ
cord-261566-fn08b0y2	225	28	pathogens	pathogen	NNS
cord-261566-fn08b0y2	225	29	such	such	JJ
cord-261566-fn08b0y2	225	30	as	as	IN
cord-261566-fn08b0y2	225	31	human	human	JJ
cord-261566-fn08b0y2	225	32	papilloma	papilloma	NN
cord-261566-fn08b0y2	225	33	virus	virus	NN
cord-261566-fn08b0y2	225	34	(	(	-LRB-
cord-261566-fn08b0y2	225	35	HPV	HPV	NNP
cord-261566-fn08b0y2	225	36	)	)	-RRB-
cord-261566-fn08b0y2	225	37	,	,	,
cord-261566-fn08b0y2	225	38	influenza	influenza	NN
cord-261566-fn08b0y2	225	39	virus	virus	NN
cord-261566-fn08b0y2	225	40	,	,	,
cord-261566-fn08b0y2	225	41	or	or	CC
cord-261566-fn08b0y2	225	42	polio	polio	NN
cord-261566-fn08b0y2	225	43	virus	virus	NN
cord-261566-fn08b0y2	225	44	.	.	.
cord-261566-fn08b0y2	226	1	All	all	DT
cord-261566-fn08b0y2	226	2	three	three	CD
cord-261566-fn08b0y2	226	3	licensed	license	VBN
cord-261566-fn08b0y2	226	4	VLP	VLP	NNP
cord-261566-fn08b0y2	226	5	-	-	HYPH
cord-261566-fn08b0y2	226	6	based	base	VBN
cord-261566-fn08b0y2	226	7	HPV	HPV	NNP
cord-261566-fn08b0y2	226	8	vaccines	vaccine	NNS
cord-261566-fn08b0y2	226	9	are	be	VBP
cord-261566-fn08b0y2	226	10	administered	administer	VBN
cord-261566-fn08b0y2	226	11	intramuscularly	intramuscularly	RB
cord-261566-fn08b0y2	226	12	and	and	CC
cord-261566-fn08b0y2	226	13	induce	induce	VB
cord-261566-fn08b0y2	226	14	a	a	DT
cord-261566-fn08b0y2	226	15	high	high	JJ
cord-261566-fn08b0y2	226	16	level	level	NN
cord-261566-fn08b0y2	226	17	of	of	IN
cord-261566-fn08b0y2	226	18	durable	durable	JJ
cord-261566-fn08b0y2	226	19	IgG	IgG	NNP
cord-261566-fn08b0y2	226	20	antibody	antibody	NN
cord-261566-fn08b0y2	226	21	response	response	NN
cord-261566-fn08b0y2	226	22	against	against	IN
cord-261566-fn08b0y2	226	23	the	the	DT
cord-261566-fn08b0y2	226	24	virus	virus	NN
cord-261566-fn08b0y2	226	25	.	.	.
cord-261566-fn08b0y2	227	1	109	109	CD
cord-261566-fn08b0y2	227	2	,	,	,
cord-261566-fn08b0y2	227	3	110	110	CD
cord-261566-fn08b0y2	227	4	These	these	DT
cord-261566-fn08b0y2	227	5	antibodies	antibody	NNS
cord-261566-fn08b0y2	227	6	are	be	VBP
cord-261566-fn08b0y2	227	7	also	also	RB
cord-261566-fn08b0y2	227	8	detectable	detectable	JJ
cord-261566-fn08b0y2	227	9	at	at	IN
cord-261566-fn08b0y2	227	10	mucosal	mucosal	JJ
cord-261566-fn08b0y2	227	11	sites	site	NNS
cord-261566-fn08b0y2	227	12	of	of	IN
cord-261566-fn08b0y2	227	13	infection	infection	NN
cord-261566-fn08b0y2	227	14	such	such	JJ
cord-261566-fn08b0y2	227	15	as	as	IN
cord-261566-fn08b0y2	227	16	oral	oral	JJ
cord-261566-fn08b0y2	227	17	cavity	cavity	NN
cord-261566-fn08b0y2	227	18	and	and	CC
cord-261566-fn08b0y2	227	19	cervix	cervix	NN
cord-261566-fn08b0y2	227	20	after	after	IN
cord-261566-fn08b0y2	227	21	vaccination	vaccination	NN
cord-261566-fn08b0y2	227	22	and	and	CC
cord-261566-fn08b0y2	227	23	serve	serve	VB
cord-261566-fn08b0y2	227	24	as	as	IN
cord-261566-fn08b0y2	227	25	the	the	DT
cord-261566-fn08b0y2	227	26	primary	primary	JJ
cord-261566-fn08b0y2	227	27	effectors	effector	NNS
cord-261566-fn08b0y2	227	28	of	of	IN
cord-261566-fn08b0y2	227	29	protection	protection	NN
cord-261566-fn08b0y2	227	30	against	against	IN
cord-261566-fn08b0y2	227	31	HPV	HPV	NNP
cord-261566-fn08b0y2	227	32	.	.	.
cord-261566-fn08b0y2	228	1	111	111	CD
cord-261566-fn08b0y2	228	2	,	,	,
cord-261566-fn08b0y2	228	3	112	112	CD
cord-261566-fn08b0y2	229	1	Currently	currently	RB
cord-261566-fn08b0y2	229	2	,	,	,
cord-261566-fn08b0y2	229	3	there	there	EX
cord-261566-fn08b0y2	229	4	are	be	VBP
cord-261566-fn08b0y2	229	5	two	two	CD
cord-261566-fn08b0y2	229	6	types	type	NNS
cord-261566-fn08b0y2	229	7	of	of	IN
cord-261566-fn08b0y2	229	8	licensed	license	VBN
cord-261566-fn08b0y2	229	9	influenza	influenza	NN
cord-261566-fn08b0y2	229	10	vaccines	vaccine	NNS
cord-261566-fn08b0y2	229	11	:	:	:
cord-261566-fn08b0y2	229	12	parenterally	parenterally	NN
cord-261566-fn08b0y2	229	13	administered	administer	VBN
cord-261566-fn08b0y2	229	14	inactivated	inactivate	VBN
cord-261566-fn08b0y2	229	15	influenza	influenza	NN
cord-261566-fn08b0y2	229	16	vaccine	vaccine	NN
cord-261566-fn08b0y2	229	17	and	and	CC
cord-261566-fn08b0y2	229	18	live	live	VB
cord-261566-fn08b0y2	229	19	attenuated	attenuated	JJ
cord-261566-fn08b0y2	229	20	influenza	influenza	NN
cord-261566-fn08b0y2	229	21	virus	virus	NN
cord-261566-fn08b0y2	229	22	vaccine	vaccine	NN
cord-261566-fn08b0y2	229	23	(	(	-LRB-
cord-261566-fn08b0y2	229	24	LAIV	LAIV	NNP
cord-261566-fn08b0y2	229	25	)	)	-RRB-
cord-261566-fn08b0y2	229	26	which	which	WDT
cord-261566-fn08b0y2	229	27	is	be	VBZ
cord-261566-fn08b0y2	229	28	delivered	deliver	VBN
cord-261566-fn08b0y2	229	29	intranasally	intranasally	RB
cord-261566-fn08b0y2	229	30	.	.	.
cord-261566-fn08b0y2	230	1	Inactivated	inactivate	VBN
cord-261566-fn08b0y2	230	2	influenza	influenza	NN
cord-261566-fn08b0y2	230	3	vaccine	vaccine	NN
cord-261566-fn08b0y2	230	4	elicits	elicit	VBZ
cord-261566-fn08b0y2	230	5	some	some	DT
cord-261566-fn08b0y2	230	6	degree	degree	NN
cord-261566-fn08b0y2	230	7	of	of	IN
cord-261566-fn08b0y2	230	8	local	local	JJ
cord-261566-fn08b0y2	230	9	IgA	IgA	NNP
cord-261566-fn08b0y2	230	10	antibodies	antibody	NNS
cord-261566-fn08b0y2	230	11	and	and	CC
cord-261566-fn08b0y2	230	12	high	high	JJ
cord-261566-fn08b0y2	230	13	levels	level	NNS
cord-261566-fn08b0y2	230	14	of	of	IN
cord-261566-fn08b0y2	230	15	systemic	systemic	JJ
cord-261566-fn08b0y2	230	16	IgG	igg	NN
cord-261566-fn08b0y2	230	17	antibodies	antibody	NNS
cord-261566-fn08b0y2	230	18	to	to	TO
cord-261566-fn08b0y2	230	19	mediate	mediate	VB
cord-261566-fn08b0y2	230	20	protection	protection	NN
cord-261566-fn08b0y2	230	21	by	by	IN
cord-261566-fn08b0y2	230	22	diffusing	diffuse	VBG
cord-261566-fn08b0y2	230	23	into	into	IN
cord-261566-fn08b0y2	230	24	the	the	DT
cord-261566-fn08b0y2	230	25	mucosal	mucosal	JJ
cord-261566-fn08b0y2	230	26	sites	site	NNS
cord-261566-fn08b0y2	230	27	.	.	.
cord-261566-fn08b0y2	231	1	LAIV	LAIV	NNP
cord-261566-fn08b0y2	231	2	,	,	,
cord-261566-fn08b0y2	231	3	in	in	IN
cord-261566-fn08b0y2	231	4	turn	turn	NN
cord-261566-fn08b0y2	231	5	,	,	,
cord-261566-fn08b0y2	231	6	mimics	mimic	VBZ
cord-261566-fn08b0y2	231	7	natural	natural	JJ
cord-261566-fn08b0y2	231	8	infection	infection	NN
cord-261566-fn08b0y2	231	9	and	and	CC
cord-261566-fn08b0y2	231	10	induce	induce	VB
cord-261566-fn08b0y2	231	11	highly	highly	RB
cord-261566-fn08b0y2	231	12	cross	cross	JJ
cord-261566-fn08b0y2	231	13	-	-	JJ
cord-261566-fn08b0y2	231	14	reactive	reactive	JJ
cord-261566-fn08b0y2	231	15	serum	serum	NN
cord-261566-fn08b0y2	231	16	IgG	igg	NN
cord-261566-fn08b0y2	231	17	,	,	,
cord-261566-fn08b0y2	231	18	mucosal	mucosal	JJ
cord-261566-fn08b0y2	231	19	IgA	IgA	NNP
cord-261566-fn08b0y2	231	20	,	,	,
cord-261566-fn08b0y2	231	21	and	and	CC
cord-261566-fn08b0y2	231	22	cellular	cellular	JJ
cord-261566-fn08b0y2	231	23	immunity	immunity	NN
cord-261566-fn08b0y2	231	24	in	in	IN
cord-261566-fn08b0y2	231	25	the	the	DT
cord-261566-fn08b0y2	231	26	recipients	recipient	NNS
cord-261566-fn08b0y2	231	27	.	.	.
cord-261566-fn08b0y2	232	1	113	113	CD
cord-261566-fn08b0y2	232	2	,	,	,
cord-261566-fn08b0y2	232	3	114	114	CD
cord-261566-fn08b0y2	232	4	Yearly	yearly	JJ
cord-261566-fn08b0y2	232	5	influenza	influenza	NN
cord-261566-fn08b0y2	232	6	vaccines	vaccine	NNS
cord-261566-fn08b0y2	232	7	are	be	VBP
cord-261566-fn08b0y2	232	8	adjusted	adjust	VBN
cord-261566-fn08b0y2	232	9	according	accord	VBG
cord-261566-fn08b0y2	232	10	to	to	IN
cord-261566-fn08b0y2	232	11	the	the	DT
cord-261566-fn08b0y2	232	12	prevalent	prevalent	JJ
cord-261566-fn08b0y2	232	13	strains	strain	NNS
cord-261566-fn08b0y2	232	14	in	in	IN
cord-261566-fn08b0y2	232	15	the	the	DT
cord-261566-fn08b0y2	232	16	coming	come	VBG
cord-261566-fn08b0y2	232	17	flu	flu	NN
cord-261566-fn08b0y2	232	18	season	season	NN
cord-261566-fn08b0y2	232	19	.	.	.
cord-261566-fn08b0y2	233	1	In	in	IN
cord-261566-fn08b0y2	233	2	clinical	clinical	JJ
cord-261566-fn08b0y2	233	3	settings	setting	NNS
cord-261566-fn08b0y2	233	4	,	,	,
cord-261566-fn08b0y2	233	5	inactivated	inactivate	VBN
cord-261566-fn08b0y2	233	6	vaccine	vaccine	NN
cord-261566-fn08b0y2	233	7	is	be	VBZ
cord-261566-fn08b0y2	233	8	found	find	VBN
cord-261566-fn08b0y2	233	9	to	to	TO
cord-261566-fn08b0y2	233	10	be	be	VB
cord-261566-fn08b0y2	233	11	more	more	RBR
cord-261566-fn08b0y2	233	12	effective	effective	JJ
cord-261566-fn08b0y2	233	13	than	than	IN
cord-261566-fn08b0y2	233	14	LAIV	LAIV	NNP
cord-261566-fn08b0y2	233	15	in	in	IN
cord-261566-fn08b0y2	233	16	preventing	prevent	VBG
cord-261566-fn08b0y2	233	17	symptomatic	symptomatic	JJ
cord-261566-fn08b0y2	233	18	disease	disease	NN
cord-261566-fn08b0y2	233	19	in	in	IN
cord-261566-fn08b0y2	233	20	healthy	healthy	JJ
cord-261566-fn08b0y2	233	21	adults	adult	NNS
cord-261566-fn08b0y2	233	22	while	while	IN
cord-261566-fn08b0y2	233	23	LAIV	LAIV	NNP
cord-261566-fn08b0y2	233	24	offers	offer	VBZ
cord-261566-fn08b0y2	233	25	greater	great	JJR
cord-261566-fn08b0y2	233	26	protection	protection	NN
cord-261566-fn08b0y2	233	27	against	against	IN
cord-261566-fn08b0y2	233	28	influenza	influenza	NN
cord-261566-fn08b0y2	233	29	disease	disease	NN
cord-261566-fn08b0y2	233	30	in	in	IN
cord-261566-fn08b0y2	233	31	children	child	NNS
cord-261566-fn08b0y2	233	32	.	.	.
cord-261566-fn08b0y2	234	1	[	[	-LRB-
cord-261566-fn08b0y2	234	2	115	115	CD
cord-261566-fn08b0y2	234	3	]	]	-RRB-
cord-261566-fn08b0y2	234	4	[	[	-LRB-
cord-261566-fn08b0y2	234	5	116	116	CD
cord-261566-fn08b0y2	234	6	]	]	-RRB-
cord-261566-fn08b0y2	234	7	[	[	-LRB-
cord-261566-fn08b0y2	234	8	117	117	CD
cord-261566-fn08b0y2	234	9	]	]	-RRB-
cord-261566-fn08b0y2	235	1	Similarly	similarly	RB
cord-261566-fn08b0y2	235	2	,	,	,
cord-261566-fn08b0y2	235	3	two	two	CD
cord-261566-fn08b0y2	235	4	types	type	NNS
cord-261566-fn08b0y2	235	5	of	of	IN
cord-261566-fn08b0y2	235	6	vaccines	vaccine	NNS
cord-261566-fn08b0y2	235	7	are	be	VBP
cord-261566-fn08b0y2	235	8	available	available	JJ
cord-261566-fn08b0y2	235	9	for	for	IN
cord-261566-fn08b0y2	235	10	polio	polio	NN
cord-261566-fn08b0y2	235	11	virus	virus	NN
cord-261566-fn08b0y2	235	12	:	:	:
cord-261566-fn08b0y2	235	13	an	an	DT
cord-261566-fn08b0y2	235	14	injectable	injectable	JJ
cord-261566-fn08b0y2	235	15	polio	polio	NN
cord-261566-fn08b0y2	235	16	vaccine	vaccine	NN
cord-261566-fn08b0y2	235	17	(	(	-LRB-
cord-261566-fn08b0y2	235	18	IPV	IPV	NNP
cord-261566-fn08b0y2	235	19	)	)	-RRB-
cord-261566-fn08b0y2	235	20	and	and	CC
cord-261566-fn08b0y2	235	21	OPV	OPV	NNP
cord-261566-fn08b0y2	235	22	.	.	.
cord-261566-fn08b0y2	236	1	Sabin	Sabin	NNP
cord-261566-fn08b0y2	236	2	OPV	OPV	NNP
cord-261566-fn08b0y2	236	3	,	,	,
cord-261566-fn08b0y2	236	4	with	with	IN
cord-261566-fn08b0y2	236	5	its	-PRON-	PRP$
cord-261566-fn08b0y2	236	6	enormous	enormous	JJ
cord-261566-fn08b0y2	236	7	impact	impact	NN
cord-261566-fn08b0y2	236	8	in	in	IN
cord-261566-fn08b0y2	236	9	disease	disease	NN
cord-261566-fn08b0y2	236	10	control	control	NN
cord-261566-fn08b0y2	236	11	worldwide	worldwide	RB
cord-261566-fn08b0y2	236	12	,	,	,
cord-261566-fn08b0y2	236	13	is	be	VBZ
cord-261566-fn08b0y2	236	14	considered	consider	VBN
cord-261566-fn08b0y2	236	15	to	to	TO
cord-261566-fn08b0y2	236	16	be	be	VB
cord-261566-fn08b0y2	236	17	the	the	DT
cord-261566-fn08b0y2	236	18	prototype	prototype	NN
cord-261566-fn08b0y2	236	19	oral	oral	JJ
cord-261566-fn08b0y2	236	20	vaccine	vaccine	NN
cord-261566-fn08b0y2	236	21	.	.	.
cord-261566-fn08b0y2	237	1	Superiority	superiority	NN
cord-261566-fn08b0y2	237	2	of	of	IN
cord-261566-fn08b0y2	237	3	OPV	OPV	NNP
cord-261566-fn08b0y2	237	4	over	over	IN
cord-261566-fn08b0y2	237	5	IPV	IPV	NNP
cord-261566-fn08b0y2	237	6	is	be	VBZ
cord-261566-fn08b0y2	237	7	attributed	attribute	VBN
cord-261566-fn08b0y2	237	8	to	to	IN
cord-261566-fn08b0y2	237	9	the	the	DT
cord-261566-fn08b0y2	237	10	induction	induction	NN
cord-261566-fn08b0y2	237	11	of	of	IN
cord-261566-fn08b0y2	237	12	high	high	JJ
cord-261566-fn08b0y2	237	13	titers	titer	NNS
cord-261566-fn08b0y2	237	14	of	of	IN
cord-261566-fn08b0y2	237	15	mucosal	mucosal	JJ
cord-261566-fn08b0y2	237	16	IgA	IgA	NNP
cord-261566-fn08b0y2	237	17	antibodies	antibody	NNS
cord-261566-fn08b0y2	237	18	.	.	.
cord-261566-fn08b0y2	238	1	118	118	CD
cord-261566-fn08b0y2	238	2	,	,	,
cord-261566-fn08b0y2	238	3	119	119	CD
cord-261566-fn08b0y2	239	1	Despite	despite	IN
cord-261566-fn08b0y2	239	2	the	the	DT
cord-261566-fn08b0y2	239	3	generation	generation	NN
cord-261566-fn08b0y2	239	4	of	of	IN
cord-261566-fn08b0y2	239	5	higher	high	JJR
cord-261566-fn08b0y2	239	6	serum	serum	NN
cord-261566-fn08b0y2	239	7	antibody	antibody	NN
cord-261566-fn08b0y2	239	8	titers	titer	NNS
cord-261566-fn08b0y2	239	9	,	,	,
cord-261566-fn08b0y2	239	10	IPV	IPV	NNP
cord-261566-fn08b0y2	239	11	provides	provide	VBZ
cord-261566-fn08b0y2	239	12	limited	limited	JJ
cord-261566-fn08b0y2	239	13	intestinal	intestinal	JJ
cord-261566-fn08b0y2	239	14	immunity	immunity	NN
cord-261566-fn08b0y2	239	15	.	.	.
cord-261566-fn08b0y2	240	1	118	118	CD
cord-261566-fn08b0y2	241	1	Due	due	IN
cord-261566-fn08b0y2	241	2	to	to	IN
cord-261566-fn08b0y2	241	3	the	the	DT
cord-261566-fn08b0y2	241	4	risk	risk	NN
cord-261566-fn08b0y2	241	5	of	of	IN
cord-261566-fn08b0y2	241	6	rare	rare	JJ
cord-261566-fn08b0y2	241	7	cases	case	NNS
cord-261566-fn08b0y2	241	8	of	of	IN
cord-261566-fn08b0y2	241	9	vaccine	vaccine	NN
cord-261566-fn08b0y2	241	10	associated	associate	VBD
cord-261566-fn08b0y2	241	11	paralytic	paralytic	JJ
cord-261566-fn08b0y2	241	12	polio	polio	NN
cord-261566-fn08b0y2	241	13	,	,	,
cord-261566-fn08b0y2	241	14	most	most	RBS
cord-261566-fn08b0y2	241	15	developed	develop	VBN
cord-261566-fn08b0y2	241	16	countries	country	NNS
cord-261566-fn08b0y2	241	17	have	have	VBP
cord-261566-fn08b0y2	241	18	switched	switch	VBN
cord-261566-fn08b0y2	241	19	to	to	IN
cord-261566-fn08b0y2	241	20	either	either	CC
cord-261566-fn08b0y2	241	21	IPV	IPV	NNP
cord-261566-fn08b0y2	241	22	or	or	CC
cord-261566-fn08b0y2	241	23	a	a	DT
cord-261566-fn08b0y2	241	24	sequential	sequential	JJ
cord-261566-fn08b0y2	241	25	combination	combination	NN
cord-261566-fn08b0y2	241	26	of	of	IN
cord-261566-fn08b0y2	241	27	IPV	IPV	NNP
cord-261566-fn08b0y2	241	28	and	and	CC
cord-261566-fn08b0y2	241	29	OPV	OPV	NNP
cord-261566-fn08b0y2	241	30	.	.	.
cord-261566-fn08b0y2	242	1	120	120	CD
cord-261566-fn08b0y2	242	2	,	,	,
cord-261566-fn08b0y2	242	3	121	121	CD
cord-261566-fn08b0y2	243	1	Based	base	VBN
cord-261566-fn08b0y2	243	2	on	on	IN
cord-261566-fn08b0y2	243	3	the	the	DT
cord-261566-fn08b0y2	243	4	substantial	substantial	JJ
cord-261566-fn08b0y2	243	5	experience	experience	NN
cord-261566-fn08b0y2	243	6	in	in	IN
cord-261566-fn08b0y2	243	7	control	control	NN
cord-261566-fn08b0y2	243	8	of	of	IN
cord-261566-fn08b0y2	243	9	mucosal	mucosal	JJ
cord-261566-fn08b0y2	243	10	pathogens	pathogen	NNS
cord-261566-fn08b0y2	243	11	using	use	VBG
cord-261566-fn08b0y2	243	12	parenterally	parenterally	RB
cord-261566-fn08b0y2	243	13	administered	administer	VBN
cord-261566-fn08b0y2	243	14	vaccines	vaccine	NNS
cord-261566-fn08b0y2	243	15	,	,	,
cord-261566-fn08b0y2	243	16	several	several	JJ
cord-261566-fn08b0y2	243	17	parenteral	parenteral	JJ
cord-261566-fn08b0y2	243	18	vaccines	vaccine	NNS
cord-261566-fn08b0y2	243	19	are	be	VBP
cord-261566-fn08b0y2	243	20	being	be	VBG
cord-261566-fn08b0y2	243	21	developed	develop	VBN
cord-261566-fn08b0y2	243	22	or	or	CC
cord-261566-fn08b0y2	243	23	evaluated	evaluate	VBN
cord-261566-fn08b0y2	243	24	against	against	IN
cord-261566-fn08b0y2	243	25	SARS	SARS	NNP
cord-261566-fn08b0y2	243	26	-	-	HYPH
cord-261566-fn08b0y2	243	27	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	243	28	.	.	.
cord-261566-fn08b0y2	244	1	Notably	notably	RB
cord-261566-fn08b0y2	244	2	,	,	,
cord-261566-fn08b0y2	244	3	DNA	dna	NN
cord-261566-fn08b0y2	244	4	-	-	HYPH
cord-261566-fn08b0y2	244	5	based	base	VBN
cord-261566-fn08b0y2	244	6	vaccine	vaccine	NN
cord-261566-fn08b0y2	244	7	by	by	IN
cord-261566-fn08b0y2	244	8	Inovio	Inovio	NNP
cord-261566-fn08b0y2	244	9	Pharmaceuticals	Pharmaceuticals	NNPS
cord-261566-fn08b0y2	244	10	(	(	-LRB-
cord-261566-fn08b0y2	244	11	INO-4800	INO-4800	NNP
cord-261566-fn08b0y2	244	12	)	)	-RRB-
cord-261566-fn08b0y2	244	13	,	,	,
cord-261566-fn08b0y2	244	14	mRNA	mrna	NN
cord-261566-fn08b0y2	244	15	-	-	HYPH
cord-261566-fn08b0y2	244	16	based	base	VBN
cord-261566-fn08b0y2	244	17	vaccine	vaccine	NN
cord-261566-fn08b0y2	244	18	by	by	IN
cord-261566-fn08b0y2	244	19	Moderna	Moderna	NNP
cord-261566-fn08b0y2	244	20	(	(	-LRB-
cord-261566-fn08b0y2	244	21	mRNA-1273	mRNA-1273	NNP
cord-261566-fn08b0y2	244	22	)	)	-RRB-
cord-261566-fn08b0y2	244	23	,	,	,
cord-261566-fn08b0y2	244	24	adenovirus	adenovirus	NN
cord-261566-fn08b0y2	244	25	-	-	HYPH
cord-261566-fn08b0y2	244	26	vectored	vectore	VBN
cord-261566-fn08b0y2	244	27	vaccine	vaccine	NN
cord-261566-fn08b0y2	244	28	(	(	-LRB-
cord-261566-fn08b0y2	244	29	ChAdOx1	ChAdOx1	NNP
cord-261566-fn08b0y2	244	30	)	)	-RRB-
cord-261566-fn08b0y2	244	31	,	,	,
cord-261566-fn08b0y2	244	32	and	and	CC
cord-261566-fn08b0y2	244	33	an	an	DT
cord-261566-fn08b0y2	244	34	inactivated	inactivate	VBN
cord-261566-fn08b0y2	244	35	virus	virus	NN
cord-261566-fn08b0y2	244	36	vaccine	vaccine	NN
cord-261566-fn08b0y2	244	37	(	(	-LRB-
cord-261566-fn08b0y2	244	38	PiCoVacc	picovacc	NN
cord-261566-fn08b0y2	244	39	)	)	-RRB-
cord-261566-fn08b0y2	244	40	are	be	VBP
cord-261566-fn08b0y2	244	41	currently	currently	RB
cord-261566-fn08b0y2	244	42	under	under	IN
cord-261566-fn08b0y2	244	43	investigation	investigation	NN
cord-261566-fn08b0y2	244	44	in	in	IN
cord-261566-fn08b0y2	244	45	human	human	JJ
cord-261566-fn08b0y2	244	46	clinical	clinical	JJ
cord-261566-fn08b0y2	244	47	trials	trial	NNS
cord-261566-fn08b0y2	244	48	.	.	.
cord-261566-fn08b0y2	245	1	[	[	-LRB-
cord-261566-fn08b0y2	245	2	122	122	CD
cord-261566-fn08b0y2	245	3	]	]	-RRB-
cord-261566-fn08b0y2	245	4	[	[	-LRB-
cord-261566-fn08b0y2	245	5	123	123	CD
cord-261566-fn08b0y2	245	6	]	]	-RRB-
cord-261566-fn08b0y2	245	7	[	[	-LRB-
cord-261566-fn08b0y2	245	8	124	124	CD
cord-261566-fn08b0y2	245	9	]	]	-RRB-
cord-261566-fn08b0y2	246	1	[	[	-LRB-
cord-261566-fn08b0y2	246	2	125	125	CD
cord-261566-fn08b0y2	246	3	]	]	-RRB-
cord-261566-fn08b0y2	247	1	Rapid	rapid	JJ
cord-261566-fn08b0y2	247	2	licensure	licensure	NN
cord-261566-fn08b0y2	247	3	and	and	CC
cord-261566-fn08b0y2	247	4	production	production	NN
cord-261566-fn08b0y2	247	5	of	of	IN
cord-261566-fn08b0y2	247	6	a	a	DT
cord-261566-fn08b0y2	247	7	mucosal	mucosal	JJ
cord-261566-fn08b0y2	247	8	vaccine	vaccine	NN
cord-261566-fn08b0y2	247	9	Time	Time	NNP
cord-261566-fn08b0y2	247	10	is	be	VBZ
cord-261566-fn08b0y2	247	11	the	the	DT
cord-261566-fn08b0y2	247	12	most	most	RBS
cord-261566-fn08b0y2	247	13	valuable	valuable	JJ
cord-261566-fn08b0y2	247	14	asset	asset	NN
cord-261566-fn08b0y2	247	15	in	in	IN
cord-261566-fn08b0y2	247	16	the	the	DT
cord-261566-fn08b0y2	247	17	rapidly	rapidly	RB
cord-261566-fn08b0y2	247	18	emerging	emerge	VBG
cord-261566-fn08b0y2	247	19	COVID-19	covid-19	JJ
cord-261566-fn08b0y2	247	20	pandemic	pandemic	NN
cord-261566-fn08b0y2	247	21	,	,	,
cord-261566-fn08b0y2	247	22	especially	especially	RB
cord-261566-fn08b0y2	247	23	in	in	IN
cord-261566-fn08b0y2	247	24	high	high	JJ
cord-261566-fn08b0y2	247	25	-	-	HYPH
cord-261566-fn08b0y2	247	26	mortality	mortality	NN
cord-261566-fn08b0y2	247	27	areas	area	NNS
cord-261566-fn08b0y2	247	28	.	.	.
cord-261566-fn08b0y2	248	1	Rapid	rapid	JJ
cord-261566-fn08b0y2	248	2	development	development	NN
cord-261566-fn08b0y2	248	3	and	and	CC
cord-261566-fn08b0y2	248	4	testing	testing	NN
cord-261566-fn08b0y2	248	5	of	of	IN
cord-261566-fn08b0y2	248	6	a	a	DT
cord-261566-fn08b0y2	248	7	viable	viable	JJ
cord-261566-fn08b0y2	248	8	vaccine	vaccine	NN
cord-261566-fn08b0y2	248	9	can	can	MD
cord-261566-fn08b0y2	248	10	be	be	VB
cord-261566-fn08b0y2	248	11	achieved	achieve	VBN
cord-261566-fn08b0y2	248	12	by	by	IN
cord-261566-fn08b0y2	248	13	adopting	adopt	VBG
cord-261566-fn08b0y2	248	14	a	a	DT
cord-261566-fn08b0y2	248	15	number	number	NN
cord-261566-fn08b0y2	248	16	of	of	IN
cord-261566-fn08b0y2	248	17	novel	novel	JJ
cord-261566-fn08b0y2	248	18	strategies	strategy	NNS
cord-261566-fn08b0y2	248	19	.	.	.
cord-261566-fn08b0y2	249	1	Instead	instead	RB
cord-261566-fn08b0y2	249	2	of	of	IN
cord-261566-fn08b0y2	249	3	developing	develop	VBG
cord-261566-fn08b0y2	249	4	a	a	DT
cord-261566-fn08b0y2	249	5	novel	novel	JJ
cord-261566-fn08b0y2	249	6	vaccine	vaccine	NN
cord-261566-fn08b0y2	249	7	development	development	NN
cord-261566-fn08b0y2	249	8	platform	platform	NN
cord-261566-fn08b0y2	249	9	,	,	,
cord-261566-fn08b0y2	249	10	utilizing	utilize	VBG
cord-261566-fn08b0y2	249	11	an	an	DT
cord-261566-fn08b0y2	249	12	existing	exist	VBG
cord-261566-fn08b0y2	249	13	vaccine	vaccine	NN
cord-261566-fn08b0y2	249	14	platform	platform	NN
cord-261566-fn08b0y2	249	15	will	will	MD
cord-261566-fn08b0y2	249	16	accelerate	accelerate	VB
cord-261566-fn08b0y2	249	17	the	the	DT
cord-261566-fn08b0y2	249	18	design	design	NN
cord-261566-fn08b0y2	249	19	and	and	CC
cord-261566-fn08b0y2	249	20	production	production	NN
cord-261566-fn08b0y2	249	21	of	of	IN
cord-261566-fn08b0y2	249	22	vaccines	vaccine	NNS
cord-261566-fn08b0y2	249	23	against	against	IN
cord-261566-fn08b0y2	249	24	SARS	SARS	NNP
cord-261566-fn08b0y2	249	25	-	-	HYPH
cord-261566-fn08b0y2	249	26	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	249	27	and	and	CC
cord-261566-fn08b0y2	249	28	will	will	MD
cord-261566-fn08b0y2	249	29	enable	enable	VB
cord-261566-fn08b0y2	249	30	a	a	DT
cord-261566-fn08b0y2	249	31	quicker	quick	JJR
cord-261566-fn08b0y2	249	32	future	future	JJ
cord-261566-fn08b0y2	249	33	response	response	NN
cord-261566-fn08b0y2	249	34	against	against	IN
cord-261566-fn08b0y2	249	35	newly	newly	RB
cord-261566-fn08b0y2	249	36	emerging	emerge	VBG
cord-261566-fn08b0y2	249	37	viruses	virus	NNS
cord-261566-fn08b0y2	249	38	.	.	.
cord-261566-fn08b0y2	250	1	Since	since	IN
cord-261566-fn08b0y2	250	2	the	the	DT
cord-261566-fn08b0y2	250	3	outbreaks	outbreak	NNS
cord-261566-fn08b0y2	250	4	of	of	IN
cord-261566-fn08b0y2	250	5	SARS	SARS	NNP
cord-261566-fn08b0y2	250	6	-	-	HYPH
cord-261566-fn08b0y2	250	7	CoV	CoV	NNP
cord-261566-fn08b0y2	250	8	and	and	CC
cord-261566-fn08b0y2	250	9	MERS	MERS	NNP
cord-261566-fn08b0y2	250	10	-	-	HYPH
cord-261566-fn08b0y2	250	11	CoV	CoV	NNP
cord-261566-fn08b0y2	250	12	,	,	,
cord-261566-fn08b0y2	250	13	several	several	JJ
cord-261566-fn08b0y2	250	14	vaccine	vaccine	NN
cord-261566-fn08b0y2	250	15	candidates	candidate	NNS
cord-261566-fn08b0y2	250	16	were	be	VBD
cord-261566-fn08b0y2	250	17	developed	develop	VBN
cord-261566-fn08b0y2	250	18	using	use	VBG
cord-261566-fn08b0y2	250	19	different	different	JJ
cord-261566-fn08b0y2	250	20	production	production	NN
cord-261566-fn08b0y2	250	21	platforms	platform	NNS
cord-261566-fn08b0y2	250	22	.	.	.
cord-261566-fn08b0y2	251	1	These	these	DT
cord-261566-fn08b0y2	251	2	established	establish	VBN
cord-261566-fn08b0y2	251	3	platforms	platform	NNS
cord-261566-fn08b0y2	251	4	are	be	VBP
cord-261566-fn08b0y2	251	5	being	be	VBG
cord-261566-fn08b0y2	251	6	used	use	VBN
cord-261566-fn08b0y2	251	7	for	for	IN
cord-261566-fn08b0y2	251	8	the	the	DT
cord-261566-fn08b0y2	251	9	development	development	NN
cord-261566-fn08b0y2	251	10	of	of	IN
cord-261566-fn08b0y2	251	11	vaccine	vaccine	NN
cord-261566-fn08b0y2	251	12	candidate	candidate	NN
cord-261566-fn08b0y2	251	13	against	against	IN
cord-261566-fn08b0y2	251	14	SARS	SARS	NNP
cord-261566-fn08b0y2	251	15	-	-	HYPH
cord-261566-fn08b0y2	251	16	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	251	17	.	.	.
cord-261566-fn08b0y2	252	1	122	122	CD
cord-261566-fn08b0y2	252	2	,	,	,
cord-261566-fn08b0y2	252	3	124	124	CD
cord-261566-fn08b0y2	252	4	,	,	,
cord-261566-fn08b0y2	252	5	126	126	CD
cord-261566-fn08b0y2	253	1	To	to	TO
cord-261566-fn08b0y2	253	2	expedite	expedite	VB
cord-261566-fn08b0y2	253	3	the	the	DT
cord-261566-fn08b0y2	253	4	process	process	NN
cord-261566-fn08b0y2	253	5	for	for	IN
cord-261566-fn08b0y2	253	6	licensure	licensure	NN
cord-261566-fn08b0y2	253	7	and	and	CC
cord-261566-fn08b0y2	253	8	use	use	NN
cord-261566-fn08b0y2	253	9	of	of	IN
cord-261566-fn08b0y2	253	10	the	the	DT
cord-261566-fn08b0y2	253	11	vaccine	vaccine	NN
cord-261566-fn08b0y2	253	12	against	against	IN
cord-261566-fn08b0y2	253	13	SARS	SARS	NNP
cord-261566-fn08b0y2	253	14	-	-	HYPH
cord-261566-fn08b0y2	253	15	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	253	16	in	in	IN
cord-261566-fn08b0y2	253	17	the	the	DT
cord-261566-fn08b0y2	253	18	wake	wake	NN
cord-261566-fn08b0y2	253	19	of	of	IN
cord-261566-fn08b0y2	253	20	the	the	DT
cord-261566-fn08b0y2	253	21	current	current	JJ
cord-261566-fn08b0y2	253	22	pandemic	pandemic	NN
cord-261566-fn08b0y2	253	23	,	,	,
cord-261566-fn08b0y2	253	24	Eyal	Eyal	NNP
cord-261566-fn08b0y2	253	25	et	et	IN
cord-261566-fn08b0y2	253	26	al	al	NNP
cord-261566-fn08b0y2	253	27	.	.	NNP
cord-261566-fn08b0y2	253	28	have	have	VBP
cord-261566-fn08b0y2	253	29	suggested	suggest	VBN
cord-261566-fn08b0y2	253	30	an	an	DT
cord-261566-fn08b0y2	253	31	alternative	alternative	JJ
cord-261566-fn08b0y2	253	32	model	model	NN
cord-261566-fn08b0y2	253	33	for	for	IN
cord-261566-fn08b0y2	253	34	accelerated	accelerated	JJ
cord-261566-fn08b0y2	253	35	rollout	rollout	NN
cord-261566-fn08b0y2	253	36	of	of	IN
cord-261566-fn08b0y2	253	37	an	an	DT
cord-261566-fn08b0y2	253	38	effective	effective	JJ
cord-261566-fn08b0y2	253	39	SARS	SARS	NNP
cord-261566-fn08b0y2	253	40	-	-	HYPH
cord-261566-fn08b0y2	253	41	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	253	42	vaccine	vaccine	NN
cord-261566-fn08b0y2	253	43	by	by	IN
cord-261566-fn08b0y2	253	44	skipping	skip	VBG
cord-261566-fn08b0y2	253	45	phase	phase	NN
cord-261566-fn08b0y2	253	46	3	3	CD
cord-261566-fn08b0y2	253	47	clinical	clinical	JJ
cord-261566-fn08b0y2	253	48	trials	trial	NNS
cord-261566-fn08b0y2	253	49	.	.	.
cord-261566-fn08b0y2	254	1	127	127	CD
cord-261566-fn08b0y2	255	1	This	this	DT
cord-261566-fn08b0y2	255	2	study	study	NN
cord-261566-fn08b0y2	255	3	proposes	propose	VBZ
cord-261566-fn08b0y2	255	4	a	a	DT
cord-261566-fn08b0y2	255	5	controlled	control	VBN
cord-261566-fn08b0y2	255	6	human	human	JJ
cord-261566-fn08b0y2	255	7	challenge	challenge	NN
cord-261566-fn08b0y2	255	8	model	model	NN
cord-261566-fn08b0y2	255	9	wherein	wherein	WRB
cord-261566-fn08b0y2	255	10	nonsusceptible	nonsusceptible	JJ
cord-261566-fn08b0y2	255	11	adult	adult	NN
cord-261566-fn08b0y2	255	12	volunteers	volunteer	NNS
cord-261566-fn08b0y2	255	13	from	from	IN
cord-261566-fn08b0y2	255	14	a	a	DT
cord-261566-fn08b0y2	255	15	healthy	healthy	JJ
cord-261566-fn08b0y2	255	16	group	group	NN
cord-261566-fn08b0y2	255	17	will	will	MD
cord-261566-fn08b0y2	255	18	be	be	VB
cord-261566-fn08b0y2	255	19	challenged	challenge	VBN
cord-261566-fn08b0y2	255	20	with	with	IN
cord-261566-fn08b0y2	255	21	an	an	DT
cord-261566-fn08b0y2	255	22	increasing	increase	VBG
cord-261566-fn08b0y2	255	23	dose	dose	NN
cord-261566-fn08b0y2	255	24	of	of	IN
cord-261566-fn08b0y2	255	25	live	live	JJ
cord-261566-fn08b0y2	255	26	virus	virus	NN
cord-261566-fn08b0y2	255	27	to	to	TO
cord-261566-fn08b0y2	255	28	determine	determine	VB
cord-261566-fn08b0y2	255	29	a	a	DT
cord-261566-fn08b0y2	255	30	dose	dose	NN
cord-261566-fn08b0y2	255	31	that	that	WDT
cord-261566-fn08b0y2	255	32	induces	induce	VBZ
cord-261566-fn08b0y2	255	33	clinical	clinical	JJ
cord-261566-fn08b0y2	255	34	symptoms	symptom	NNS
cord-261566-fn08b0y2	255	35	similar	similar	JJ
cord-261566-fn08b0y2	255	36	to	to	IN
cord-261566-fn08b0y2	255	37	the	the	DT
cord-261566-fn08b0y2	255	38	natural	natural	JJ
cord-261566-fn08b0y2	255	39	infection	infection	NN
cord-261566-fn08b0y2	255	40	in	in	IN
cord-261566-fn08b0y2	255	41	the	the	DT
cord-261566-fn08b0y2	255	42	individuals	individual	NNS
cord-261566-fn08b0y2	255	43	of	of	IN
cord-261566-fn08b0y2	255	44	similar	similar	JJ
cord-261566-fn08b0y2	255	45	age	age	NN
cord-261566-fn08b0y2	255	46	(	(	-LRB-
cord-261566-fn08b0y2	255	47	Preparatory	preparatory	JJ
cord-261566-fn08b0y2	255	48	phase	phase	NN
cord-261566-fn08b0y2	255	49	)	)	-RRB-
cord-261566-fn08b0y2	255	50	.	.	.
cord-261566-fn08b0y2	256	1	After	after	IN
cord-261566-fn08b0y2	256	2	this	this	DT
cord-261566-fn08b0y2	256	3	dose	dose	NN
cord-261566-fn08b0y2	256	4	for	for	IN
cord-261566-fn08b0y2	256	5	controlled	control	VBN
cord-261566-fn08b0y2	256	6	human	human	JJ
cord-261566-fn08b0y2	256	7	challenge	challenge	NN
cord-261566-fn08b0y2	256	8	model	model	NN
cord-261566-fn08b0y2	256	9	has	have	VBZ
cord-261566-fn08b0y2	256	10	been	be	VBN
cord-261566-fn08b0y2	256	11	optimized	optimize	VBN
cord-261566-fn08b0y2	256	12	,	,	,
cord-261566-fn08b0y2	256	13	a	a	DT
cord-261566-fn08b0y2	256	14	randomized	randomized	JJ
cord-261566-fn08b0y2	256	15	cohort	cohort	NN
cord-261566-fn08b0y2	256	16	of	of	IN
cord-261566-fn08b0y2	256	17	volunteers	volunteer	NNS
cord-261566-fn08b0y2	256	18	will	will	MD
cord-261566-fn08b0y2	256	19	receive	receive	VB
cord-261566-fn08b0y2	256	20	the	the	DT
cord-261566-fn08b0y2	256	21	candidate	candidate	NN
cord-261566-fn08b0y2	256	22	vaccine	vaccine	NN
cord-261566-fn08b0y2	256	23	or	or	CC
cord-261566-fn08b0y2	256	24	placebo	placebo	NN
cord-261566-fn08b0y2	256	25	before	before	IN
cord-261566-fn08b0y2	256	26	being	be	VBG
cord-261566-fn08b0y2	256	27	challenged	challenge	VBN
cord-261566-fn08b0y2	256	28	with	with	IN
cord-261566-fn08b0y2	256	29	the	the	DT
cord-261566-fn08b0y2	256	30	controlled	control	VBN
cord-261566-fn08b0y2	256	31	dose	dose	NN
cord-261566-fn08b0y2	256	32	of	of	IN
cord-261566-fn08b0y2	256	33	the	the	DT
cord-261566-fn08b0y2	256	34	live	live	JJ
cord-261566-fn08b0y2	256	35	virus	virus	NN
cord-261566-fn08b0y2	256	36	(	(	-LRB-
cord-261566-fn08b0y2	256	37	Phase	phase	NN
cord-261566-fn08b0y2	256	38	1	1	CD
cord-261566-fn08b0y2	256	39	)	)	-RRB-
cord-261566-fn08b0y2	256	40	.	.	.
cord-261566-fn08b0y2	257	1	The	the	DT
cord-261566-fn08b0y2	257	2	successful	successful	JJ
cord-261566-fn08b0y2	257	3	vaccine	vaccine	NN
cord-261566-fn08b0y2	257	4	candidates	candidate	NNS
cord-261566-fn08b0y2	257	5	can	can	MD
cord-261566-fn08b0y2	257	6	then	then	RB
cord-261566-fn08b0y2	257	7	be	be	VB
cord-261566-fn08b0y2	257	8	administered	administer	VBN
cord-261566-fn08b0y2	257	9	to	to	IN
cord-261566-fn08b0y2	257	10	a	a	DT
cord-261566-fn08b0y2	257	11	large	large	JJ
cord-261566-fn08b0y2	257	12	cohort	cohort	NN
cord-261566-fn08b0y2	257	13	of	of	IN
cord-261566-fn08b0y2	257	14	individuals	individual	NNS
cord-261566-fn08b0y2	257	15	for	for	IN
cord-261566-fn08b0y2	257	16	evaluation	evaluation	NN
cord-261566-fn08b0y2	257	17	of	of	IN
cord-261566-fn08b0y2	257	18	shortterm	shortterm	JJ
cord-261566-fn08b0y2	257	19	safety	safety	NN
cord-261566-fn08b0y2	257	20	prior	prior	RB
cord-261566-fn08b0y2	257	21	to	to	IN
cord-261566-fn08b0y2	257	22	vaccine	vaccine	NN
cord-261566-fn08b0y2	257	23	rollout	rollout	NN
cord-261566-fn08b0y2	257	24	(	(	-LRB-
cord-261566-fn08b0y2	257	25	Phase	phase	NN
cord-261566-fn08b0y2	257	26	2	2	CD
cord-261566-fn08b0y2	257	27	)	)	-RRB-
cord-261566-fn08b0y2	257	28	.	.	.
cord-261566-fn08b0y2	258	1	This	this	DT
cord-261566-fn08b0y2	258	2	accelerated	accelerated	JJ
cord-261566-fn08b0y2	258	3	licensure	licensure	NN
cord-261566-fn08b0y2	258	4	of	of	IN
cord-261566-fn08b0y2	258	5	the	the	DT
cord-261566-fn08b0y2	258	6	vaccine	vaccine	NN
cord-261566-fn08b0y2	258	7	can	can	MD
cord-261566-fn08b0y2	258	8	be	be	VB
cord-261566-fn08b0y2	258	9	followed	follow	VBN
cord-261566-fn08b0y2	258	10	up	up	RP
cord-261566-fn08b0y2	258	11	with	with	IN
cord-261566-fn08b0y2	258	12	post	post	JJ
cord-261566-fn08b0y2	258	13	-	-	JJ
cord-261566-fn08b0y2	258	14	approval	approval	JJ
cord-261566-fn08b0y2	258	15	surveillance	surveillance	NN
cord-261566-fn08b0y2	258	16	to	to	TO
cord-261566-fn08b0y2	258	17	monitor	monitor	VB
cord-261566-fn08b0y2	258	18	the	the	DT
cord-261566-fn08b0y2	258	19	occurrence	occurrence	NN
cord-261566-fn08b0y2	258	20	of	of	IN
cord-261566-fn08b0y2	258	21	rare	rare	JJ
cord-261566-fn08b0y2	258	22	side	side	NN
cord-261566-fn08b0y2	258	23	effects	effect	NNS
cord-261566-fn08b0y2	258	24	and	and	CC
cord-261566-fn08b0y2	258	25	long	long	JJ
cord-261566-fn08b0y2	258	26	-	-	HYPH
cord-261566-fn08b0y2	258	27	term	term	NN
cord-261566-fn08b0y2	258	28	efficacy	efficacy	NN
cord-261566-fn08b0y2	258	29	for	for	IN
cord-261566-fn08b0y2	258	30	future	future	JJ
cord-261566-fn08b0y2	258	31	regulatory	regulatory	JJ
cord-261566-fn08b0y2	258	32	approvals	approval	NNS
cord-261566-fn08b0y2	258	33	.	.	.
cord-261566-fn08b0y2	259	1	The	the	DT
cord-261566-fn08b0y2	259	2	overwhelming	overwhelming	JJ
cord-261566-fn08b0y2	259	3	demand	demand	NN
cord-261566-fn08b0y2	259	4	for	for	IN
cord-261566-fn08b0y2	259	5	a	a	DT
cord-261566-fn08b0y2	259	6	SARS	SARS	NNP
cord-261566-fn08b0y2	259	7	-	-	HYPH
cord-261566-fn08b0y2	259	8	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	259	9	vaccine	vaccine	NN
cord-261566-fn08b0y2	259	10	in	in	IN
cord-261566-fn08b0y2	259	11	the	the	DT
cord-261566-fn08b0y2	259	12	current	current	JJ
cord-261566-fn08b0y2	259	13	pandemic	pandemic	NN
cord-261566-fn08b0y2	259	14	by	by	IN
cord-261566-fn08b0y2	259	15	far	far	RB
cord-261566-fn08b0y2	259	16	exceeds	exceed	VBZ
cord-261566-fn08b0y2	259	17	the	the	DT
cord-261566-fn08b0y2	259	18	existing	exist	VBG
cord-261566-fn08b0y2	259	19	production	production	NN
cord-261566-fn08b0y2	259	20	capacity	capacity	NN
cord-261566-fn08b0y2	259	21	.	.	.
cord-261566-fn08b0y2	260	1	To	to	TO
cord-261566-fn08b0y2	260	2	deliver	deliver	VB
cord-261566-fn08b0y2	260	3	required	require	VBN
cord-261566-fn08b0y2	260	4	quantities	quantity	NNS
cord-261566-fn08b0y2	260	5	of	of	IN
cord-261566-fn08b0y2	260	6	the	the	DT
cord-261566-fn08b0y2	260	7	successful	successful	JJ
cord-261566-fn08b0y2	260	8	vaccine	vaccine	NN
cord-261566-fn08b0y2	260	9	,	,	,
cord-261566-fn08b0y2	260	10	production	production	NN
cord-261566-fn08b0y2	260	11	process	process	NN
cord-261566-fn08b0y2	260	12	will	will	MD
cord-261566-fn08b0y2	260	13	have	have	VB
cord-261566-fn08b0y2	260	14	to	to	TO
cord-261566-fn08b0y2	260	15	be	be	VB
cord-261566-fn08b0y2	260	16	ramped	ramp	VBN
cord-261566-fn08b0y2	260	17	up	up	RP
cord-261566-fn08b0y2	260	18	to	to	IN
cord-261566-fn08b0y2	260	19	an	an	DT
cord-261566-fn08b0y2	260	20	enormous	enormous	JJ
cord-261566-fn08b0y2	260	21	scale	scale	NN
cord-261566-fn08b0y2	260	22	.	.	.
cord-261566-fn08b0y2	261	1	The	the	DT
cord-261566-fn08b0y2	261	2	necessary	necessary	JJ
cord-261566-fn08b0y2	261	3	infrastructure	infrastructure	NN
cord-261566-fn08b0y2	261	4	can	can	MD
cord-261566-fn08b0y2	261	5	be	be	VB
cord-261566-fn08b0y2	261	6	developed	develop	VBN
cord-261566-fn08b0y2	261	7	simultaneously	simultaneously	RB
cord-261566-fn08b0y2	261	8	with	with	IN
cord-261566-fn08b0y2	261	9	the	the	DT
cord-261566-fn08b0y2	261	10	continued	continued	JJ
cord-261566-fn08b0y2	261	11	production	production	NN
cord-261566-fn08b0y2	261	12	on	on	IN
cord-261566-fn08b0y2	261	13	existing	exist	VBG
cord-261566-fn08b0y2	261	14	capacity	capacity	NN
cord-261566-fn08b0y2	261	15	.	.	.
cord-261566-fn08b0y2	262	1	Alternatively	alternatively	RB
cord-261566-fn08b0y2	262	2	,	,	,
cord-261566-fn08b0y2	262	3	rapid	rapid	JJ
cord-261566-fn08b0y2	262	4	manufacturing	manufacturing	NN
cord-261566-fn08b0y2	262	5	of	of	IN
cord-261566-fn08b0y2	262	6	a	a	DT
cord-261566-fn08b0y2	262	7	successful	successful	JJ
cord-261566-fn08b0y2	262	8	vaccine	vaccine	NN
cord-261566-fn08b0y2	262	9	can	can	MD
cord-261566-fn08b0y2	262	10	be	be	VB
cord-261566-fn08b0y2	262	11	facilitated	facilitate	VBN
cord-261566-fn08b0y2	262	12	by	by	IN
cord-261566-fn08b0y2	262	13	adopting	adopt	VBG
cord-261566-fn08b0y2	262	14	a	a	DT
cord-261566-fn08b0y2	262	15	new	new	JJ
cord-261566-fn08b0y2	262	16	pandemic	pandemic	NN
cord-261566-fn08b0y2	262	17	paradigm	paradigm	NN
cord-261566-fn08b0y2	262	18	,	,	,
cord-261566-fn08b0y2	262	19	with	with	IN
cord-261566-fn08b0y2	262	20	a	a	DT
cord-261566-fn08b0y2	262	21	fast	fast	JJ
cord-261566-fn08b0y2	262	22	start	start	NN
cord-261566-fn08b0y2	262	23	and	and	CC
cord-261566-fn08b0y2	262	24	many	many	JJ
cord-261566-fn08b0y2	262	25	steps	step	NNS
cord-261566-fn08b0y2	262	26	of	of	IN
cord-261566-fn08b0y2	262	27	vaccine	vaccine	NN
cord-261566-fn08b0y2	262	28	development	development	NN
cord-261566-fn08b0y2	262	29	and	and	CC
cord-261566-fn08b0y2	262	30	production	production	NN
cord-261566-fn08b0y2	262	31	executed	execute	VBN
cord-261566-fn08b0y2	262	32	in	in	IN
cord-261566-fn08b0y2	262	33	parallel	parallel	NN
cord-261566-fn08b0y2	262	34	before	before	IN
cord-261566-fn08b0y2	262	35	confirming	confirm	VBG
cord-261566-fn08b0y2	262	36	a	a	DT
cord-261566-fn08b0y2	262	37	successful	successful	JJ
cord-261566-fn08b0y2	262	38	outcome	outcome	NN
cord-261566-fn08b0y2	262	39	of	of	IN
cord-261566-fn08b0y2	262	40	another	another	DT
cord-261566-fn08b0y2	262	41	step	step	NN
cord-261566-fn08b0y2	262	42	.	.	.
cord-261566-fn08b0y2	263	1	128	128	CD
cord-261566-fn08b0y2	264	1	In	in	IN
cord-261566-fn08b0y2	264	2	recent	recent	JJ
cord-261566-fn08b0y2	264	3	years	year	NNS
cord-261566-fn08b0y2	264	4	,	,	,
cord-261566-fn08b0y2	264	5	rapid	rapid	JJ
cord-261566-fn08b0y2	264	6	production	production	NN
cord-261566-fn08b0y2	264	7	of	of	IN
cord-261566-fn08b0y2	264	8	live	live	JJ
cord-261566-fn08b0y2	264	9	attenuated	attenuated	JJ
cord-261566-fn08b0y2	264	10	vaccines	vaccine	NNS
cord-261566-fn08b0y2	264	11	is	be	VBZ
cord-261566-fn08b0y2	264	12	being	be	VBG
cord-261566-fn08b0y2	264	13	facilitated	facilitate	VBN
cord-261566-fn08b0y2	264	14	by	by	IN
cord-261566-fn08b0y2	264	15	utilizing	utilize	VBG
cord-261566-fn08b0y2	264	16	reverse	reverse	JJ
cord-261566-fn08b0y2	264	17	genetics	genetics	NN
cord-261566-fn08b0y2	264	18	process	process	NN
cord-261566-fn08b0y2	264	19	that	that	WDT
cord-261566-fn08b0y2	264	20	involves	involve	VBZ
cord-261566-fn08b0y2	264	21	the	the	DT
cord-261566-fn08b0y2	264	22	precise	precise	JJ
cord-261566-fn08b0y2	264	23	deletion	deletion	NN
cord-261566-fn08b0y2	264	24	of	of	IN
cord-261566-fn08b0y2	264	25	specific	specific	JJ
cord-261566-fn08b0y2	264	26	genes	gene	NNS
cord-261566-fn08b0y2	264	27	of	of	IN
cord-261566-fn08b0y2	264	28	viral	viral	JJ
cord-261566-fn08b0y2	264	29	genome	genome	NN
cord-261566-fn08b0y2	264	30	.	.	.
cord-261566-fn08b0y2	265	1	129	129	CD
cord-261566-fn08b0y2	265	2	Deletion	deletion	NN
cord-261566-fn08b0y2	265	3	of	of	IN
cord-261566-fn08b0y2	265	4	pathogenic	pathogenic	JJ
cord-261566-fn08b0y2	265	5	components	component	NNS
cord-261566-fn08b0y2	265	6	of	of	IN
cord-261566-fn08b0y2	265	7	the	the	DT
cord-261566-fn08b0y2	265	8	pathogen	pathogen	NN
cord-261566-fn08b0y2	265	9	is	be	VBZ
cord-261566-fn08b0y2	265	10	advantageous	advantageous	JJ
cord-261566-fn08b0y2	265	11	over	over	IN
cord-261566-fn08b0y2	265	12	traditional	traditional	JJ
cord-261566-fn08b0y2	265	13	methods	method	NNS
cord-261566-fn08b0y2	265	14	of	of	IN
cord-261566-fn08b0y2	265	15	viral	viral	JJ
cord-261566-fn08b0y2	265	16	attenuation	attenuation	NN
cord-261566-fn08b0y2	265	17	in	in	IN
cord-261566-fn08b0y2	265	18	terms	term	NNS
cord-261566-fn08b0y2	265	19	of	of	IN
cord-261566-fn08b0y2	265	20	safety	safety	NN
cord-261566-fn08b0y2	265	21	and	and	CC
cord-261566-fn08b0y2	265	22	efficacy	efficacy	NN
cord-261566-fn08b0y2	265	23	of	of	IN
cord-261566-fn08b0y2	265	24	a	a	DT
cord-261566-fn08b0y2	265	25	vaccine	vaccine	NN
cord-261566-fn08b0y2	265	26	.	.	.
cord-261566-fn08b0y2	266	1	The	the	DT
cord-261566-fn08b0y2	266	2	current	current	JJ
cord-261566-fn08b0y2	266	3	COVID-19	covid-19	JJ
cord-261566-fn08b0y2	266	4	pandemic	pandemic	NN
cord-261566-fn08b0y2	266	5	has	have	VBZ
cord-261566-fn08b0y2	266	6	virtually	virtually	RB
cord-261566-fn08b0y2	266	7	brought	bring	VBN
cord-261566-fn08b0y2	266	8	most	most	JJS
cord-261566-fn08b0y2	266	9	world	world	NN
cord-261566-fn08b0y2	266	10	economies	economy	NNS
cord-261566-fn08b0y2	266	11	to	to	IN
cord-261566-fn08b0y2	266	12	a	a	DT
cord-261566-fn08b0y2	266	13	halt	halt	NN
cord-261566-fn08b0y2	266	14	and	and	CC
cord-261566-fn08b0y2	266	15	severely	severely	RB
cord-261566-fn08b0y2	266	16	impacted	impact	VBD
cord-261566-fn08b0y2	266	17	the	the	DT
cord-261566-fn08b0y2	266	18	lives	life	NNS
cord-261566-fn08b0y2	266	19	of	of	IN
cord-261566-fn08b0y2	266	20	a	a	DT
cord-261566-fn08b0y2	266	21	large	large	JJ
cord-261566-fn08b0y2	266	22	proportion	proportion	NN
cord-261566-fn08b0y2	266	23	of	of	IN
cord-261566-fn08b0y2	266	24	the	the	DT
cord-261566-fn08b0y2	266	25	world	world	NN
cord-261566-fn08b0y2	266	26	population	population	NN
cord-261566-fn08b0y2	266	27	.	.	.
cord-261566-fn08b0y2	267	1	Development	development	NN
cord-261566-fn08b0y2	267	2	of	of	IN
cord-261566-fn08b0y2	267	3	a	a	DT
cord-261566-fn08b0y2	267	4	viable	viable	JJ
cord-261566-fn08b0y2	267	5	SARS	SARS	NNP
cord-261566-fn08b0y2	267	6	-	-	HYPH
cord-261566-fn08b0y2	267	7	CoV	CoV	NNP
cord-261566-fn08b0y2	267	8	vaccine	vaccine	NN
cord-261566-fn08b0y2	267	9	is	be	VBZ
cord-261566-fn08b0y2	267	10	imperative	imperative	JJ
cord-261566-fn08b0y2	267	11	to	to	TO
cord-261566-fn08b0y2	267	12	reduce	reduce	VB
cord-261566-fn08b0y2	267	13	mortality	mortality	NN
cord-261566-fn08b0y2	267	14	and	and	CC
cord-261566-fn08b0y2	267	15	morbidity	morbidity	NN
cord-261566-fn08b0y2	267	16	associated	associate	VBN
cord-261566-fn08b0y2	267	17	with	with	IN
cord-261566-fn08b0y2	267	18	this	this	DT
cord-261566-fn08b0y2	267	19	novel	novel	JJ
cord-261566-fn08b0y2	267	20	virus	virus	NN
cord-261566-fn08b0y2	267	21	outbreak	outbreak	NN
cord-261566-fn08b0y2	267	22	.	.	.
cord-261566-fn08b0y2	268	1	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	268	2	vaccines	vaccine	NNS
cord-261566-fn08b0y2	268	3	offer	offer	VBP
cord-261566-fn08b0y2	268	4	better	well	JJR
cord-261566-fn08b0y2	268	5	patient	patient	JJ
cord-261566-fn08b0y2	268	6	compliance	compliance	NN
cord-261566-fn08b0y2	268	7	in	in	IN
cord-261566-fn08b0y2	268	8	terms	term	NNS
cord-261566-fn08b0y2	268	9	of	of	IN
cord-261566-fn08b0y2	268	10	the	the	DT
cord-261566-fn08b0y2	268	11	physical	physical	JJ
cord-261566-fn08b0y2	268	12	and	and	CC
cord-261566-fn08b0y2	268	13	psychological	psychological	JJ
cord-261566-fn08b0y2	268	14	comfort	comfort	NN
cord-261566-fn08b0y2	268	15	due	due	IN
cord-261566-fn08b0y2	268	16	to	to	IN
cord-261566-fn08b0y2	268	17	absence	absence	NN
cord-261566-fn08b0y2	268	18	of	of	IN
cord-261566-fn08b0y2	268	19	needlestick	needlestick	NN
cord-261566-fn08b0y2	268	20	injury	injury	NN
cord-261566-fn08b0y2	268	21	and	and	CC
cord-261566-fn08b0y2	268	22	thus	thus	RB
cord-261566-fn08b0y2	268	23	are	be	VBP
cord-261566-fn08b0y2	268	24	highly	highly	RB
cord-261566-fn08b0y2	268	25	compatible	compatible	JJ
cord-261566-fn08b0y2	268	26	for	for	IN
cord-261566-fn08b0y2	268	27	mass	mass	JJ
cord-261566-fn08b0y2	268	28	immunization	immunization	NN
cord-261566-fn08b0y2	268	29	in	in	IN
cord-261566-fn08b0y2	268	30	a	a	DT
cord-261566-fn08b0y2	268	31	pandemic	pandemic	NN
cord-261566-fn08b0y2	268	32	scenario	scenario	NN
cord-261566-fn08b0y2	268	33	.	.	.
cord-261566-fn08b0y2	269	1	Vaccine	vaccine	NN
cord-261566-fn08b0y2	269	2	administration	administration	NN
cord-261566-fn08b0y2	269	3	using	use	VBG
cord-261566-fn08b0y2	269	4	injection	injection	NN
cord-261566-fn08b0y2	269	5	involves	involve	VBZ
cord-261566-fn08b0y2	269	6	the	the	DT
cord-261566-fn08b0y2	269	7	cost	cost	NN
cord-261566-fn08b0y2	269	8	of	of	IN
cord-261566-fn08b0y2	269	9	injection	injection	NN
cord-261566-fn08b0y2	269	10	device	device	NN
cord-261566-fn08b0y2	269	11	,	,	,
cord-261566-fn08b0y2	269	12	it	-PRON-	PRP
cord-261566-fn08b0y2	269	13	's	be	VBZ
cord-261566-fn08b0y2	269	14	safe	safe	JJ
cord-261566-fn08b0y2	269	15	disposal	disposal	NN
cord-261566-fn08b0y2	269	16	,	,	,
cord-261566-fn08b0y2	269	17	and	and	CC
cord-261566-fn08b0y2	269	18	the	the	DT
cord-261566-fn08b0y2	269	19	employment	employment	NN
cord-261566-fn08b0y2	269	20	of	of	IN
cord-261566-fn08b0y2	269	21	trained	train	VBN
cord-261566-fn08b0y2	269	22	medical	medical	JJ
cord-261566-fn08b0y2	269	23	staff	staff	NN
cord-261566-fn08b0y2	269	24	which	which	WDT
cord-261566-fn08b0y2	269	25	adds	add	VBZ
cord-261566-fn08b0y2	269	26	a	a	DT
cord-261566-fn08b0y2	269	27	considerable	considerable	JJ
cord-261566-fn08b0y2	269	28	cost	cost	NN
cord-261566-fn08b0y2	269	29	for	for	IN
cord-261566-fn08b0y2	269	30	mass	mass	JJ
cord-261566-fn08b0y2	269	31	vaccination	vaccination	NN
cord-261566-fn08b0y2	269	32	especially	especially	RB
cord-261566-fn08b0y2	269	33	in	in	IN
cord-261566-fn08b0y2	269	34	developing	develop	VBG
cord-261566-fn08b0y2	269	35	countries	country	NNS
cord-261566-fn08b0y2	269	36	.	.	.
cord-261566-fn08b0y2	270	1	Mucosally	mucosally	RB
cord-261566-fn08b0y2	270	2	administered	administer	VBD
cord-261566-fn08b0y2	270	3	vaccines	vaccine	NNS
cord-261566-fn08b0y2	270	4	also	also	RB
cord-261566-fn08b0y2	270	5	abrogate	abrogate	VBP
cord-261566-fn08b0y2	270	6	the	the	DT
cord-261566-fn08b0y2	270	7	risk	risk	NN
cord-261566-fn08b0y2	270	8	of	of	IN
cord-261566-fn08b0y2	270	9	transmission	transmission	NN
cord-261566-fn08b0y2	270	10	of	of	IN
cord-261566-fn08b0y2	270	11	infections	infection	NNS
cord-261566-fn08b0y2	270	12	by	by	IN
cord-261566-fn08b0y2	270	13	injection	injection	NN
cord-261566-fn08b0y2	270	14	devices	device	NNS
cord-261566-fn08b0y2	270	15	.	.	.
cord-261566-fn08b0y2	271	1	Despite	despite	IN
cord-261566-fn08b0y2	271	2	our	-PRON-	PRP$
cord-261566-fn08b0y2	271	3	detailed	detailed	JJ
cord-261566-fn08b0y2	271	4	understanding	understanding	NN
cord-261566-fn08b0y2	271	5	of	of	IN
cord-261566-fn08b0y2	271	6	mucosal	mucosal	JJ
cord-261566-fn08b0y2	271	7	system	system	NN
cord-261566-fn08b0y2	271	8	in	in	IN
cord-261566-fn08b0y2	271	9	mice	mouse	NNS
cord-261566-fn08b0y2	271	10	,	,	,
cord-261566-fn08b0y2	271	11	the	the	DT
cord-261566-fn08b0y2	271	12	complex	complex	JJ
cord-261566-fn08b0y2	271	13	cellular	cellular	JJ
cord-261566-fn08b0y2	271	14	and	and	CC
cord-261566-fn08b0y2	271	15	molecular	molecular	JJ
cord-261566-fn08b0y2	271	16	interplay	interplay	NN
cord-261566-fn08b0y2	271	17	of	of	IN
cord-261566-fn08b0y2	271	18	different	different	JJ
cord-261566-fn08b0y2	271	19	component	component	NN
cord-261566-fn08b0y2	271	20	of	of	IN
cord-261566-fn08b0y2	271	21	innate	innate	JJ
cord-261566-fn08b0y2	271	22	immune	immune	JJ
cord-261566-fn08b0y2	271	23	response	response	NN
cord-261566-fn08b0y2	271	24	to	to	IN
cord-261566-fn08b0y2	271	25	mucosal	mucosal	JJ
cord-261566-fn08b0y2	271	26	vaccination	vaccination	NN
cord-261566-fn08b0y2	271	27	in	in	IN
cord-261566-fn08b0y2	271	28	humans	human	NNS
cord-261566-fn08b0y2	271	29	is	be	VBZ
cord-261566-fn08b0y2	271	30	still	still	RB
cord-261566-fn08b0y2	271	31	poorly	poorly	RB
cord-261566-fn08b0y2	271	32	deciphered	decipher	VBN
cord-261566-fn08b0y2	271	33	.	.	.
cord-261566-fn08b0y2	272	1	Additionally	additionally	RB
cord-261566-fn08b0y2	272	2	,	,	,
cord-261566-fn08b0y2	272	3	the	the	DT
cord-261566-fn08b0y2	272	4	emergence	emergence	NN
cord-261566-fn08b0y2	272	5	and	and	CC
cord-261566-fn08b0y2	272	6	rapid	rapid	JJ
cord-261566-fn08b0y2	272	7	global	global	JJ
cord-261566-fn08b0y2	272	8	spread	spread	NN
cord-261566-fn08b0y2	272	9	of	of	IN
cord-261566-fn08b0y2	272	10	SARS	SARS	NNP
cord-261566-fn08b0y2	272	11	-	-	HYPH
cord-261566-fn08b0y2	272	12	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	272	13	has	have	VBZ
cord-261566-fn08b0y2	272	14	provided	provide	VBN
cord-261566-fn08b0y2	272	15	a	a	DT
cord-261566-fn08b0y2	272	16	very	very	RB
cord-261566-fn08b0y2	272	17	small	small	JJ
cord-261566-fn08b0y2	272	18	window	window	NN
cord-261566-fn08b0y2	272	19	for	for	IN
cord-261566-fn08b0y2	272	20	basic	basic	JJ
cord-261566-fn08b0y2	272	21	and	and	CC
cord-261566-fn08b0y2	272	22	translational	translational	JJ
cord-261566-fn08b0y2	272	23	studies	study	NNS
cord-261566-fn08b0y2	272	24	that	that	WDT
cord-261566-fn08b0y2	272	25	propel	propel	VBP
cord-261566-fn08b0y2	272	26	the	the	DT
cord-261566-fn08b0y2	272	27	development	development	NN
cord-261566-fn08b0y2	272	28	and	and	CC
cord-261566-fn08b0y2	272	29	evaluation	evaluation	NN
cord-261566-fn08b0y2	272	30	of	of	IN
cord-261566-fn08b0y2	272	31	vaccine	vaccine	NN
cord-261566-fn08b0y2	272	32	against	against	IN
cord-261566-fn08b0y2	272	33	a	a	DT
cord-261566-fn08b0y2	272	34	pathogen	pathogen	NN
cord-261566-fn08b0y2	272	35	.	.	.
cord-261566-fn08b0y2	273	1	While	while	IN
cord-261566-fn08b0y2	273	2	the	the	DT
cord-261566-fn08b0y2	273	3	knowledge	knowledge	NN
cord-261566-fn08b0y2	273	4	gained	gain	VBN
cord-261566-fn08b0y2	273	5	from	from	IN
cord-261566-fn08b0y2	273	6	previous	previous	JJ
cord-261566-fn08b0y2	273	7	studies	study	NNS
cord-261566-fn08b0y2	273	8	on	on	IN
cord-261566-fn08b0y2	273	9	SARS	SARS	NNP
cord-261566-fn08b0y2	273	10	-	-	HYPH
cord-261566-fn08b0y2	273	11	CoV	CoV	NNP
cord-261566-fn08b0y2	273	12	and	and	CC
cord-261566-fn08b0y2	273	13	MERS	MERS	NNP
cord-261566-fn08b0y2	273	14	-	-	HYPH
cord-261566-fn08b0y2	273	15	CoV	CoV	NNP
cord-261566-fn08b0y2	273	16	can	can	MD
cord-261566-fn08b0y2	273	17	be	be	VB
cord-261566-fn08b0y2	273	18	used	use	VBN
cord-261566-fn08b0y2	273	19	for	for	IN
cord-261566-fn08b0y2	273	20	SARS	SARS	NNP
cord-261566-fn08b0y2	273	21	-	-	HYPH
cord-261566-fn08b0y2	273	22	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	273	23	vaccine	vaccine	NN
cord-261566-fn08b0y2	273	24	development	development	NN
cord-261566-fn08b0y2	273	25	,	,	,
cord-261566-fn08b0y2	273	26	it	-PRON-	PRP
cord-261566-fn08b0y2	273	27	is	be	VBZ
cord-261566-fn08b0y2	273	28	yet	yet	RB
cord-261566-fn08b0y2	273	29	uncertain	uncertain	JJ
cord-261566-fn08b0y2	273	30	as	as	IN
cord-261566-fn08b0y2	273	31	to	to	IN
cord-261566-fn08b0y2	273	32	what	what	WDT
cord-261566-fn08b0y2	273	33	extent	extent	NN
cord-261566-fn08b0y2	273	34	it	-PRON-	PRP
cord-261566-fn08b0y2	273	35	will	will	MD
cord-261566-fn08b0y2	273	36	work	work	VB
cord-261566-fn08b0y2	273	37	for	for	IN
cord-261566-fn08b0y2	273	38	SARS	SARS	NNP
cord-261566-fn08b0y2	273	39	-	-	HYPH
cord-261566-fn08b0y2	273	40	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	273	41	or	or	CC
cord-261566-fn08b0y2	273	42	whether	whether	IN
cord-261566-fn08b0y2	273	43	correlates	correlate	NNS
cord-261566-fn08b0y2	273	44	of	of	IN
cord-261566-fn08b0y2	273	45	protection	protection	NN
cord-261566-fn08b0y2	273	46	used	use	VBN
cord-261566-fn08b0y2	273	47	will	will	MD
cord-261566-fn08b0y2	273	48	faithfully	faithfully	RB
cord-261566-fn08b0y2	273	49	predict	predict	VB
cord-261566-fn08b0y2	273	50	protective	protective	JJ
cord-261566-fn08b0y2	273	51	efficacy	efficacy	NN
cord-261566-fn08b0y2	273	52	.	.	.
cord-261566-fn08b0y2	274	1	Potential	potential	JJ
cord-261566-fn08b0y2	274	2	ADE	ade	NN
cord-261566-fn08b0y2	274	3	and	and	CC
cord-261566-fn08b0y2	274	4	waning	waning	NN
cord-261566-fn08b0y2	274	5	of	of	IN
cord-261566-fn08b0y2	274	6	vaccine	vaccine	NN
cord-261566-fn08b0y2	274	7	-	-	HYPH
cord-261566-fn08b0y2	274	8	induced	induce	VBN
cord-261566-fn08b0y2	274	9	immune	immune	JJ
cord-261566-fn08b0y2	274	10	response	response	NN
cord-261566-fn08b0y2	274	11	represent	represent	VBP
cord-261566-fn08b0y2	274	12	other	other	JJ
cord-261566-fn08b0y2	274	13	obstacles	obstacle	NNS
cord-261566-fn08b0y2	274	14	in	in	IN
cord-261566-fn08b0y2	274	15	the	the	DT
cord-261566-fn08b0y2	274	16	development	development	NN
cord-261566-fn08b0y2	274	17	of	of	IN
cord-261566-fn08b0y2	274	18	a	a	DT
cord-261566-fn08b0y2	274	19	mucosal	mucosal	JJ
cord-261566-fn08b0y2	274	20	vaccine	vaccine	NN
cord-261566-fn08b0y2	274	21	against	against	IN
cord-261566-fn08b0y2	274	22	SARS	SARS	NNP
cord-261566-fn08b0y2	274	23	-	-	HYPH
cord-261566-fn08b0y2	274	24	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	274	25	.	.	.
cord-261566-fn08b0y2	275	1	The	the	DT
cord-261566-fn08b0y2	275	2	currently	currently	RB
cord-261566-fn08b0y2	275	3	licensed	license	VBN
cord-261566-fn08b0y2	275	4	mucosal	mucosal	JJ
cord-261566-fn08b0y2	275	5	vaccines	vaccine	NNS
cord-261566-fn08b0y2	275	6	against	against	IN
cord-261566-fn08b0y2	275	7	viral	viral	JJ
cord-261566-fn08b0y2	275	8	pathogens	pathogen	NNS
cord-261566-fn08b0y2	275	9	are	be	VBP
cord-261566-fn08b0y2	275	10	exclusively	exclusively	RB
cord-261566-fn08b0y2	275	11	live	live	RB
cord-261566-fn08b0y2	275	12	-	-	HYPH
cord-261566-fn08b0y2	275	13	attenuated	attenuated	JJ
cord-261566-fn08b0y2	275	14	.	.	.
cord-261566-fn08b0y2	276	1	The	the	DT
cord-261566-fn08b0y2	276	2	development	development	NN
cord-261566-fn08b0y2	276	3	of	of	IN
cord-261566-fn08b0y2	276	4	a	a	DT
cord-261566-fn08b0y2	276	5	safe	safe	JJ
cord-261566-fn08b0y2	276	6	and	and	CC
cord-261566-fn08b0y2	276	7	immunogenic	immunogenic	JJ
cord-261566-fn08b0y2	276	8	live	live	RB
cord-261566-fn08b0y2	276	9	-	-	HYPH
cord-261566-fn08b0y2	276	10	attenuated	attenuated	JJ
cord-261566-fn08b0y2	276	11	vaccine	vaccine	NN
cord-261566-fn08b0y2	276	12	is	be	VBZ
cord-261566-fn08b0y2	276	13	an	an	DT
cord-261566-fn08b0y2	276	14	attractive	attractive	JJ
cord-261566-fn08b0y2	276	15	possibility	possibility	NN
cord-261566-fn08b0y2	276	16	for	for	IN
cord-261566-fn08b0y2	276	17	mucosal	mucosal	JJ
cord-261566-fn08b0y2	276	18	vaccine	vaccine	NN
cord-261566-fn08b0y2	276	19	against	against	IN
cord-261566-fn08b0y2	276	20	SARS	SARS	NNP
cord-261566-fn08b0y2	276	21	-	-	HYPH
cord-261566-fn08b0y2	276	22	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	276	23	.	.	.
cord-261566-fn08b0y2	277	1	Live	live	JJ
cord-261566-fn08b0y2	277	2	attenuated	attenuated	JJ
cord-261566-fn08b0y2	277	3	vaccines	vaccine	NNS
cord-261566-fn08b0y2	277	4	,	,	,
cord-261566-fn08b0y2	277	5	by	by	IN
cord-261566-fn08b0y2	277	6	definition	definition	NN
cord-261566-fn08b0y2	277	7	establish	establish	VB
cord-261566-fn08b0y2	277	8	a	a	DT
cord-261566-fn08b0y2	277	9	mild	mild	JJ
cord-261566-fn08b0y2	277	10	infection	infection	NN
cord-261566-fn08b0y2	277	11	at	at	IN
cord-261566-fn08b0y2	277	12	the	the	DT
cord-261566-fn08b0y2	277	13	immunization	immunization	NN
cord-261566-fn08b0y2	277	14	site	site	NN
cord-261566-fn08b0y2	277	15	and	and	CC
cord-261566-fn08b0y2	277	16	exhibit	exhibit	VB
cord-261566-fn08b0y2	277	17	some	some	DT
cord-261566-fn08b0y2	277	18	level	level	NN
cord-261566-fn08b0y2	277	19	of	of	IN
cord-261566-fn08b0y2	277	20	in	in	RB
cord-261566-fn08b0y2	277	21	-	-	HYPH
cord-261566-fn08b0y2	277	22	built	build	VBN
cord-261566-fn08b0y2	277	23	adjuvanticity	adjuvanticity	NN
cord-261566-fn08b0y2	277	24	thereby	thereby	RB
cord-261566-fn08b0y2	277	25	ensuring	ensure	VBG
cord-261566-fn08b0y2	277	26	the	the	DT
cord-261566-fn08b0y2	277	27	delivery	delivery	NN
cord-261566-fn08b0y2	277	28	of	of	IN
cord-261566-fn08b0y2	277	29	a	a	DT
cord-261566-fn08b0y2	277	30	higher	high	JJR
cord-261566-fn08b0y2	277	31	antigen	antigen	NN
cord-261566-fn08b0y2	277	32	dose	dose	NN
cord-261566-fn08b0y2	277	33	and	and	CC
cord-261566-fn08b0y2	277	34	better	well	JJR
cord-261566-fn08b0y2	277	35	targeting	targeting	NN
cord-261566-fn08b0y2	277	36	of	of	IN
cord-261566-fn08b0y2	277	37	mucosal	mucosal	JJ
cord-261566-fn08b0y2	277	38	inductive	inductive	JJ
cord-261566-fn08b0y2	277	39	sites	site	NNS
cord-261566-fn08b0y2	277	40	for	for	IN
cord-261566-fn08b0y2	277	41	immunostimulation	immunostimulation	NN
cord-261566-fn08b0y2	277	42	.	.	.
cord-261566-fn08b0y2	278	1	This	this	DT
cord-261566-fn08b0y2	278	2	candidate	candidate	NN
cord-261566-fn08b0y2	278	3	vaccine	vaccine	NN
cord-261566-fn08b0y2	278	4	can	can	MD
cord-261566-fn08b0y2	278	5	be	be	VB
cord-261566-fn08b0y2	278	6	easily	easily	RB
cord-261566-fn08b0y2	278	7	administered	administer	VBN
cord-261566-fn08b0y2	278	8	orally	orally	RB
cord-261566-fn08b0y2	278	9	as	as	IN
cord-261566-fn08b0y2	278	10	encapsulated	encapsulate	VBN
cord-261566-fn08b0y2	278	11	antigens	antigen	NNS
cord-261566-fn08b0y2	278	12	or	or	CC
cord-261566-fn08b0y2	278	13	can	can	MD
cord-261566-fn08b0y2	278	14	be	be	VB
cord-261566-fn08b0y2	278	15	delivered	deliver	VBN
cord-261566-fn08b0y2	278	16	through	through	IN
cord-261566-fn08b0y2	278	17	the	the	DT
cord-261566-fn08b0y2	278	18	intranasal	intranasal	NN
cord-261566-fn08b0y2	278	19	route	route	NN
cord-261566-fn08b0y2	278	20	via	via	IN
cord-261566-fn08b0y2	278	21	droplets	droplet	NNS
cord-261566-fn08b0y2	278	22	and	and	CC
cord-261566-fn08b0y2	278	23	aerosol	aerosol	NN
cord-261566-fn08b0y2	278	24	spray	spray	NN
cord-261566-fn08b0y2	278	25	.	.	.
cord-261566-fn08b0y2	279	1	COVID-19	covid-19	JJ
cord-261566-fn08b0y2	279	2	pandemic	pandemic	NN
cord-261566-fn08b0y2	279	3	demands	demand	VBZ
cord-261566-fn08b0y2	279	4	for	for	IN
cord-261566-fn08b0y2	279	5	adopting	adopt	VBG
cord-261566-fn08b0y2	279	6	nonconventional	nonconventional	JJ
cord-261566-fn08b0y2	279	7	approaches	approach	NNS
cord-261566-fn08b0y2	279	8	for	for	IN
cord-261566-fn08b0y2	279	9	a	a	DT
cord-261566-fn08b0y2	279	10	viable	viable	JJ
cord-261566-fn08b0y2	279	11	mucosal	mucosal	JJ
cord-261566-fn08b0y2	279	12	vaccine	vaccine	NN
cord-261566-fn08b0y2	279	13	development	development	NN
cord-261566-fn08b0y2	279	14	,	,	,
cord-261566-fn08b0y2	279	15	hastening	hasten	VBG
cord-261566-fn08b0y2	279	16	the	the	DT
cord-261566-fn08b0y2	279	17	vaccine	vaccine	NN
cord-261566-fn08b0y2	279	18	licensure	licensure	NN
cord-261566-fn08b0y2	279	19	process	process	NN
cord-261566-fn08b0y2	279	20	,	,	,
cord-261566-fn08b0y2	279	21	utilizing	utilize	VBG
cord-261566-fn08b0y2	279	22	existing	exist	VBG
cord-261566-fn08b0y2	279	23	vaccine	vaccine	NN
cord-261566-fn08b0y2	279	24	development	development	NN
cord-261566-fn08b0y2	279	25	and	and	CC
cord-261566-fn08b0y2	279	26	manufacturing	manufacturing	NN
cord-261566-fn08b0y2	279	27	platforms	platform	NNS
cord-261566-fn08b0y2	279	28	,	,	,
cord-261566-fn08b0y2	279	29	and	and	CC
cord-261566-fn08b0y2	279	30	ensuring	ensure	VBG
cord-261566-fn08b0y2	279	31	global	global	JJ
cord-261566-fn08b0y2	279	32	distribution	distribution	NN
cord-261566-fn08b0y2	279	33	of	of	IN
cord-261566-fn08b0y2	279	34	the	the	DT
cord-261566-fn08b0y2	279	35	licensed	licensed	JJ
cord-261566-fn08b0y2	279	36	vaccine	vaccine	NN
cord-261566-fn08b0y2	279	37	in	in	IN
cord-261566-fn08b0y2	279	38	time	time	NN
cord-261566-fn08b0y2	279	39	to	to	TO
cord-261566-fn08b0y2	279	40	minimize	minimize	VB
cord-261566-fn08b0y2	279	41	the	the	DT
cord-261566-fn08b0y2	279	42	impact	impact	NN
cord-261566-fn08b0y2	279	43	of	of	IN
cord-261566-fn08b0y2	279	44	COVID-19	COVID-19	NNP
cord-261566-fn08b0y2	279	45	across	across	IN
cord-261566-fn08b0y2	279	46	the	the	DT
cord-261566-fn08b0y2	279	47	globe	globe	NN
cord-261566-fn08b0y2	279	48	.	.	.
cord-261566-fn08b0y2	280	1	It	-PRON-	PRP
cord-261566-fn08b0y2	280	2	will	will	MD
cord-261566-fn08b0y2	280	3	also	also	RB
cord-261566-fn08b0y2	280	4	need	need	VB
cord-261566-fn08b0y2	280	5	an	an	DT
cord-261566-fn08b0y2	280	6	unprecedented	unprecedented	JJ
cord-261566-fn08b0y2	280	7	scale	scale	NN
cord-261566-fn08b0y2	280	8	-	-	HYPH
cord-261566-fn08b0y2	280	9	up	up	NN
cord-261566-fn08b0y2	280	10	of	of	IN
cord-261566-fn08b0y2	280	11	the	the	DT
cord-261566-fn08b0y2	280	12	manufacturing	manufacturing	NN
cord-261566-fn08b0y2	280	13	process	process	NN
cord-261566-fn08b0y2	280	14	and	and	CC
cord-261566-fn08b0y2	280	15	concerted	concerted	JJ
cord-261566-fn08b0y2	280	16	efforts	effort	NNS
cord-261566-fn08b0y2	280	17	of	of	IN
cord-261566-fn08b0y2	280	18	the	the	DT
cord-261566-fn08b0y2	280	19	supply	supply	NN
cord-261566-fn08b0y2	280	20	chains	chain	NNS
cord-261566-fn08b0y2	280	21	to	to	TO
cord-261566-fn08b0y2	280	22	make	make	VB
cord-261566-fn08b0y2	280	23	the	the	DT
cord-261566-fn08b0y2	280	24	vaccine	vaccine	NN
cord-261566-fn08b0y2	280	25	available	available	JJ
cord-261566-fn08b0y2	280	26	before	before	IN
cord-261566-fn08b0y2	280	27	this	this	DT
cord-261566-fn08b0y2	280	28	pandemic	pandemic	NN
cord-261566-fn08b0y2	280	29	is	be	VBZ
cord-261566-fn08b0y2	280	30	over	over	RB
cord-261566-fn08b0y2	280	31	.	.	.
cord-261566-fn08b0y2	281	1	Learning	learn	VBG
cord-261566-fn08b0y2	281	2	from	from	IN
cord-261566-fn08b0y2	281	3	the	the	DT
cord-261566-fn08b0y2	281	4	COVID-19	COVID-19	NNP
cord-261566-fn08b0y2	281	5	pandemic	pandemic	NN
cord-261566-fn08b0y2	281	6	,	,	,
cord-261566-fn08b0y2	281	7	sustained	sustained	JJ
cord-261566-fn08b0y2	281	8	investments	investment	NNS
cord-261566-fn08b0y2	281	9	in	in	IN
cord-261566-fn08b0y2	281	10	vaccine	vaccine	NN
cord-261566-fn08b0y2	281	11	development	development	NN
cord-261566-fn08b0y2	281	12	and	and	CC
cord-261566-fn08b0y2	281	13	production	production	NN
cord-261566-fn08b0y2	281	14	infrastructure	infrastructure	NN
cord-261566-fn08b0y2	281	15	should	should	MD
cord-261566-fn08b0y2	281	16	be	be	VB
cord-261566-fn08b0y2	281	17	made	make	VBN
cord-261566-fn08b0y2	281	18	to	to	TO
cord-261566-fn08b0y2	281	19	save	save	VB
cord-261566-fn08b0y2	281	20	human	human	JJ
cord-261566-fn08b0y2	281	21	lives	life	NNS
cord-261566-fn08b0y2	281	22	and	and	CC
cord-261566-fn08b0y2	281	23	curtail	curtail	VB
cord-261566-fn08b0y2	281	24	the	the	DT
cord-261566-fn08b0y2	281	25	economic	economic	JJ
cord-261566-fn08b0y2	281	26	impact	impact	NN
cord-261566-fn08b0y2	281	27	associated	associate	VBN
cord-261566-fn08b0y2	281	28	with	with	IN
cord-261566-fn08b0y2	281	29	a	a	DT
cord-261566-fn08b0y2	281	30	looming	loom	VBG
cord-261566-fn08b0y2	281	31	viral	viral	JJ
cord-261566-fn08b0y2	281	32	pandemic	pandemic	NN
cord-261566-fn08b0y2	281	33	.	.	.
cord-261566-fn08b0y2	282	1	Moreover	moreover	RB
cord-261566-fn08b0y2	282	2	,	,	,
cord-261566-fn08b0y2	282	3	continued	continue	VBD
cord-261566-fn08b0y2	282	4	global	global	JJ
cord-261566-fn08b0y2	282	5	surveillance	surveillance	NN
cord-261566-fn08b0y2	282	6	and	and	CC
cord-261566-fn08b0y2	282	7	vigilance	vigilance	NN
cord-261566-fn08b0y2	282	8	in	in	IN
cord-261566-fn08b0y2	282	9	the	the	DT
cord-261566-fn08b0y2	282	10	post	post	JJ
cord-261566-fn08b0y2	282	11	-	-	JJ
cord-261566-fn08b0y2	282	12	pandemic	pandemic	JJ
cord-261566-fn08b0y2	282	13	scenario	scenario	NN
cord-261566-fn08b0y2	282	14	should	should	MD
cord-261566-fn08b0y2	282	15	be	be	VB
cord-261566-fn08b0y2	282	16	practiced	practice	VBN
cord-261566-fn08b0y2	282	17	to	to	TO
cord-261566-fn08b0y2	282	18	help	help	VB
cord-261566-fn08b0y2	282	19	the	the	DT
cord-261566-fn08b0y2	282	20	world	world	NN
cord-261566-fn08b0y2	282	21	counter	counter	VB
cord-261566-fn08b0y2	282	22	a	a	DT
cord-261566-fn08b0y2	282	23	second	second	JJ
cord-261566-fn08b0y2	282	24	wave	wave	NN
cord-261566-fn08b0y2	282	25	of	of	IN
cord-261566-fn08b0y2	282	26	COVID-19	covid-19	JJ
cord-261566-fn08b0y2	282	27	or	or	CC
cord-261566-fn08b0y2	282	28	other	other	JJ
cord-261566-fn08b0y2	282	29	possible	possible	JJ
cord-261566-fn08b0y2	282	30	future	future	JJ
cord-261566-fn08b0y2	282	31	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	282	32	outbreaks	outbreak	NNS
cord-261566-fn08b0y2	282	33	.	.	.
cord-261566-fn08b0y2	283	1	The	the	DT
cord-261566-fn08b0y2	283	2	authors	author	NNS
cord-261566-fn08b0y2	283	3	declare	declare	VBP
cord-261566-fn08b0y2	283	4	no	no	DT
cord-261566-fn08b0y2	283	5	potential	potential	JJ
cord-261566-fn08b0y2	283	6	conflict	conflict	NN
cord-261566-fn08b0y2	283	7	of	of	IN
cord-261566-fn08b0y2	283	8	interest	interest	NN
cord-261566-fn08b0y2	283	9	.	.	.
cord-261566-fn08b0y2	284	1	The	the	DT
cord-261566-fn08b0y2	284	2	compilation	compilation	NN
cord-261566-fn08b0y2	284	3	of	of	IN
cord-261566-fn08b0y2	284	4	this	this	DT
cord-261566-fn08b0y2	284	5	review	review	NN
cord-261566-fn08b0y2	284	6	was	be	VBD
cord-261566-fn08b0y2	284	7	financially	financially	RB
cord-261566-fn08b0y2	284	8	supported	support	VBN
cord-261566-fn08b0y2	284	9	by	by	IN
cord-261566-fn08b0y2	284	10	Department	Department	NNP
cord-261566-fn08b0y2	284	11	of	of	IN
cord-261566-fn08b0y2	284	12	Science	Science	NNP
cord-261566-fn08b0y2	284	13	and	and	CC
cord-261566-fn08b0y2	284	14	Technology	Technology	NNP
cord-261566-fn08b0y2	284	15	,	,	,
cord-261566-fn08b0y2	284	16	India	India	NNP
cord-261566-fn08b0y2	284	17	Science	Science	NNP
cord-261566-fn08b0y2	284	18	and	and	CC
cord-261566-fn08b0y2	284	19	Engineering	Engineering	NNP
cord-261566-fn08b0y2	284	20	Research	Research	NNP
cord-261566-fn08b0y2	284	21	Board	Board	NNP
cord-261566-fn08b0y2	284	22	(	(	-LRB-
cord-261566-fn08b0y2	284	23	SERB	SERB	NNP
cord-261566-fn08b0y2	284	24	)	)	-RRB-
cord-261566-fn08b0y2	284	25	Govt	Govt	NNP
cord-261566-fn08b0y2	284	26	of	of	IN
cord-261566-fn08b0y2	284	27	India	India	NNP
cord-261566-fn08b0y2	284	28	[	[	-LRB-
cord-261566-fn08b0y2	284	29	IPA/2020/000054	IPA/2020/000054	NNP
cord-261566-fn08b0y2	284	30	]	]	-RRB-
cord-261566-fn08b0y2	284	31	.	.	.
cord-261566-fn08b0y2	285	1	Epidemiology	epidemiology	NN
cord-261566-fn08b0y2	285	2	and	and	CC
cord-261566-fn08b0y2	285	3	cause	cause	NN
cord-261566-fn08b0y2	285	4	of	of	IN
cord-261566-fn08b0y2	285	5	severe	severe	JJ
cord-261566-fn08b0y2	285	6	acute	acute	JJ
cord-261566-fn08b0y2	285	7	respiratory	respiratory	JJ
cord-261566-fn08b0y2	285	8	syndrome	syndrome	NN
cord-261566-fn08b0y2	285	9	(	(	-LRB-
cord-261566-fn08b0y2	285	10	SARS	SARS	NNP
cord-261566-fn08b0y2	285	11	)	)	-RRB-
cord-261566-fn08b0y2	285	12	in	in	IN
cord-261566-fn08b0y2	285	13	Guangdong	Guangdong	NNP
cord-261566-fn08b0y2	285	14	,	,	,
cord-261566-fn08b0y2	285	15	People	People	NNPS
cord-261566-fn08b0y2	285	16	's	's	POS
cord-261566-fn08b0y2	285	17	Republic	Republic	NNP
cord-261566-fn08b0y2	285	18	of	of	IN
cord-261566-fn08b0y2	285	19	China	China	NNP
cord-261566-fn08b0y2	285	20	Isolation	Isolation	NNP
cord-261566-fn08b0y2	285	21	of	of	IN
cord-261566-fn08b0y2	285	22	a	a	DT
cord-261566-fn08b0y2	285	23	novel	novel	JJ
cord-261566-fn08b0y2	285	24	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	285	25	from	from	IN
cord-261566-fn08b0y2	285	26	a	a	DT
cord-261566-fn08b0y2	285	27	man	man	NN
cord-261566-fn08b0y2	285	28	with	with	IN
cord-261566-fn08b0y2	285	29	pneumonia	pneumonia	NN
cord-261566-fn08b0y2	285	30	in	in	IN
cord-261566-fn08b0y2	285	31	Saudi	Saudi	NNP
cord-261566-fn08b0y2	285	32	Arabia	Arabia	NNP
cord-261566-fn08b0y2	285	33	Clinical	clinical	JJ
cord-261566-fn08b0y2	285	34	features	feature	NNS
cord-261566-fn08b0y2	285	35	of	of	IN
cord-261566-fn08b0y2	285	36	patients	patient	NNS
cord-261566-fn08b0y2	285	37	infected	infect	VBN
cord-261566-fn08b0y2	285	38	with	with	IN
cord-261566-fn08b0y2	285	39	2019	2019	CD
cord-261566-fn08b0y2	285	40	novel	novel	JJ
cord-261566-fn08b0y2	285	41	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	285	42	in	in	IN
cord-261566-fn08b0y2	285	43	Wuhan	Wuhan	NNP
cord-261566-fn08b0y2	286	1	The	the	DT
cord-261566-fn08b0y2	286	2	species	specie	NNS
cord-261566-fn08b0y2	286	3	Severe	severe	JJ
cord-261566-fn08b0y2	286	4	acute	acute	JJ
cord-261566-fn08b0y2	286	5	respiratory	respiratory	JJ
cord-261566-fn08b0y2	286	6	syndrome	syndrome	NN
cord-261566-fn08b0y2	286	7	-	-	HYPH
cord-261566-fn08b0y2	286	8	related	relate	VBN
cord-261566-fn08b0y2	286	9	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	286	10	:	:	:
cord-261566-fn08b0y2	286	11	classifying	classify	VBG
cord-261566-fn08b0y2	286	12	2019-nCoV	2019-ncov	CD
cord-261566-fn08b0y2	286	13	and	and	CC
cord-261566-fn08b0y2	286	14	naming	name	VBG
cord-261566-fn08b0y2	286	15	it	-PRON-	PRP
cord-261566-fn08b0y2	286	16	SARS	SARS	NNP
cord-261566-fn08b0y2	286	17	-	-	HYPH
cord-261566-fn08b0y2	286	18	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	287	1	A	a	DT
cord-261566-fn08b0y2	287	2	pneumonia	pneumonia	NN
cord-261566-fn08b0y2	287	3	outbreak	outbreak	NN
cord-261566-fn08b0y2	287	4	associated	associate	VBN
cord-261566-fn08b0y2	287	5	with	with	IN
cord-261566-fn08b0y2	287	6	a	a	DT
cord-261566-fn08b0y2	287	7	new	new	JJ
cord-261566-fn08b0y2	287	8	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	287	9	of	of	IN
cord-261566-fn08b0y2	287	10	probable	probable	JJ
cord-261566-fn08b0y2	287	11	bat	bat	NN
cord-261566-fn08b0y2	287	12	origin	origin	NN
cord-261566-fn08b0y2	287	13	SARS	SARS	NNP
cord-261566-fn08b0y2	287	14	-	-	HYPH
cord-261566-fn08b0y2	287	15	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	287	16	vaccines	vaccine	NNS
cord-261566-fn08b0y2	287	17	:	:	:
cord-261566-fn08b0y2	287	18	status	status	NN
cord-261566-fn08b0y2	287	19	report	report	NN
cord-261566-fn08b0y2	287	20	Origin	Origin	NNP
cord-261566-fn08b0y2	287	21	and	and	CC
cord-261566-fn08b0y2	287	22	evolution	evolution	NN
cord-261566-fn08b0y2	287	23	of	of	IN
cord-261566-fn08b0y2	287	24	pathogenic	pathogenic	JJ
cord-261566-fn08b0y2	287	25	coronaviruses	coronaviruse	NNS
cord-261566-fn08b0y2	287	26	Coronaviruses	Coronaviruses	NNP
cord-261566-fn08b0y2	287	27	:	:	:
cord-261566-fn08b0y2	287	28	an	an	DT
cord-261566-fn08b0y2	287	29	overview	overview	NN
cord-261566-fn08b0y2	287	30	of	of	IN
cord-261566-fn08b0y2	287	31	their	-PRON-	PRP$
cord-261566-fn08b0y2	287	32	replication	replication	NN
cord-261566-fn08b0y2	287	33	and	and	CC
cord-261566-fn08b0y2	287	34	pathogenesis	pathogenesis	NN
cord-261566-fn08b0y2	288	1	The	the	DT
cord-261566-fn08b0y2	288	2	spike	spike	NN
cord-261566-fn08b0y2	288	3	protein	protein	NN
cord-261566-fn08b0y2	288	4	of	of	IN
cord-261566-fn08b0y2	288	5	SARS	SARS	NNP
cord-261566-fn08b0y2	288	6	-	-	HYPH
cord-261566-fn08b0y2	288	7	CoV	CoV	NNP
cord-261566-fn08b0y2	288	8	-	-	:
cord-261566-fn08b0y2	288	9	a	a	DT
cord-261566-fn08b0y2	288	10	target	target	NN
cord-261566-fn08b0y2	288	11	for	for	IN
cord-261566-fn08b0y2	288	12	vaccine	vaccine	NN
cord-261566-fn08b0y2	288	13	and	and	CC
cord-261566-fn08b0y2	288	14	therapeutic	therapeutic	JJ
cord-261566-fn08b0y2	288	15	development	development	NN
cord-261566-fn08b0y2	289	1	Dipeptidyl	Dipeptidyl	NNP
cord-261566-fn08b0y2	289	2	peptidase	peptidase	NN
cord-261566-fn08b0y2	289	3	4	4	CD
cord-261566-fn08b0y2	289	4	is	be	VBZ
cord-261566-fn08b0y2	289	5	a	a	DT
cord-261566-fn08b0y2	289	6	functional	functional	JJ
cord-261566-fn08b0y2	289	7	receptor	receptor	NN
cord-261566-fn08b0y2	289	8	for	for	IN
cord-261566-fn08b0y2	289	9	the	the	DT
cord-261566-fn08b0y2	289	10	emerging	emerge	VBG
cord-261566-fn08b0y2	289	11	human	human	JJ
cord-261566-fn08b0y2	289	12	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	289	13	-	-	HYPH
cord-261566-fn08b0y2	289	14	EMC	EMC	NNP
cord-261566-fn08b0y2	289	15	Angiotensin	Angiotensin	NNP
cord-261566-fn08b0y2	289	16	-	-	HYPH
cord-261566-fn08b0y2	289	17	converting	convert	VBG
cord-261566-fn08b0y2	289	18	enzyme	enzyme	NN
cord-261566-fn08b0y2	289	19	2	2	CD
cord-261566-fn08b0y2	289	20	is	be	VBZ
cord-261566-fn08b0y2	289	21	a	a	DT
cord-261566-fn08b0y2	289	22	functional	functional	JJ
cord-261566-fn08b0y2	289	23	receptor	receptor	NN
cord-261566-fn08b0y2	289	24	for	for	IN
cord-261566-fn08b0y2	289	25	the	the	DT
cord-261566-fn08b0y2	289	26	SARS	SARS	NNP
cord-261566-fn08b0y2	289	27	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	290	1	A	a	DT
cord-261566-fn08b0y2	290	2	cluster	cluster	NN
cord-261566-fn08b0y2	290	3	of	of	IN
cord-261566-fn08b0y2	290	4	cases	case	NNS
cord-261566-fn08b0y2	290	5	of	of	IN
cord-261566-fn08b0y2	290	6	severe	severe	JJ
cord-261566-fn08b0y2	290	7	acute	acute	JJ
cord-261566-fn08b0y2	290	8	respiratory	respiratory	JJ
cord-261566-fn08b0y2	290	9	syndrome	syndrome	NN
cord-261566-fn08b0y2	290	10	in	in	IN
cord-261566-fn08b0y2	290	11	Hong	Hong	NNP
cord-261566-fn08b0y2	290	12	Kong	Kong	NNP
cord-261566-fn08b0y2	290	13	Identification	Identification	NNP
cord-261566-fn08b0y2	290	14	of	of	IN
cord-261566-fn08b0y2	290	15	severe	severe	JJ
cord-261566-fn08b0y2	290	16	acute	acute	JJ
cord-261566-fn08b0y2	290	17	respiratory	respiratory	JJ
cord-261566-fn08b0y2	290	18	syndrome	syndrome	NN
cord-261566-fn08b0y2	290	19	in	in	IN
cord-261566-fn08b0y2	290	20	Canada	Canada	NNP
cord-261566-fn08b0y2	290	21	Clinical	Clinical	NNP
cord-261566-fn08b0y2	290	22	and	and	CC
cord-261566-fn08b0y2	290	23	immunologic	immunologic	JJ
cord-261566-fn08b0y2	290	24	features	feature	NNS
cord-261566-fn08b0y2	290	25	in	in	IN
cord-261566-fn08b0y2	290	26	severe	severe	JJ
cord-261566-fn08b0y2	290	27	and	and	CC
cord-261566-fn08b0y2	290	28	moderate	moderate	JJ
cord-261566-fn08b0y2	290	29	Coronavirus	Coronavirus	NNP
cord-261566-fn08b0y2	290	30	Disease	Disease	NNP
cord-261566-fn08b0y2	290	31	Zhang	Zhang	NNP
cord-261566-fn08b0y2	290	32	W	W	NNP
cord-261566-fn08b0y2	290	33	Viral	Viral	NNP
cord-261566-fn08b0y2	290	34	dynamics	dynamic	NNS
cord-261566-fn08b0y2	290	35	in	in	IN
cord-261566-fn08b0y2	290	36	mild	mild	JJ
cord-261566-fn08b0y2	290	37	and	and	CC
cord-261566-fn08b0y2	290	38	severe	severe	JJ
cord-261566-fn08b0y2	290	39	cases	case	NNS
cord-261566-fn08b0y2	290	40	of	of	IN
cord-261566-fn08b0y2	290	41	COVID-19	covid-19	NN
cord-261566-fn08b0y2	290	42	.	.	.
cord-261566-fn08b0y2	291	1	The	the	DT
cord-261566-fn08b0y2	291	2	Lancet	Lancet	NNP
cord-261566-fn08b0y2	291	3	Infectious	Infectious	NNP
cord-261566-fn08b0y2	291	4	Diseases	Diseases	NNPS
cord-261566-fn08b0y2	291	5	Dysregulated	Dysregulated	NNP
cord-261566-fn08b0y2	291	6	type	type	NN
cord-261566-fn08b0y2	292	1	I	-PRON-	PRP
cord-261566-fn08b0y2	292	2	interferon	interferon	VBD
cord-261566-fn08b0y2	292	3	and	and	CC
cord-261566-fn08b0y2	292	4	inflammatory	inflammatory	JJ
cord-261566-fn08b0y2	292	5	monocyte	monocyte	JJ
cord-261566-fn08b0y2	292	6	-	-	HYPH
cord-261566-fn08b0y2	292	7	macrophage	macrophage	NN
cord-261566-fn08b0y2	292	8	responses	response	NNS
cord-261566-fn08b0y2	292	9	cause	cause	VBP
cord-261566-fn08b0y2	292	10	lethal	lethal	JJ
cord-261566-fn08b0y2	292	11	pneumonia	pneumonia	NN
cord-261566-fn08b0y2	292	12	in	in	IN
cord-261566-fn08b0y2	292	13	SARS	SARS	NNP
cord-261566-fn08b0y2	292	14	-	-	HYPH
cord-261566-fn08b0y2	292	15	CoV	CoV	NNP
cord-261566-fn08b0y2	292	16	-	-	HYPH
cord-261566-fn08b0y2	292	17	infected	infect	VBN
cord-261566-fn08b0y2	292	18	mice	mouse	NNS
cord-261566-fn08b0y2	293	1	COVID-19	COVID-19	NNP
cord-261566-fn08b0y2	293	2	,	,	,
cord-261566-fn08b0y2	293	3	an	an	DT
cord-261566-fn08b0y2	293	4	emerging	emerge	VBG
cord-261566-fn08b0y2	293	5	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	293	6	infection	infection	NN
cord-261566-fn08b0y2	293	7	:	:	:
cord-261566-fn08b0y2	294	1	advances	advance	NNS
cord-261566-fn08b0y2	294	2	and	and	CC
cord-261566-fn08b0y2	294	3	prospects	prospect	NNS
cord-261566-fn08b0y2	294	4	in	in	IN
cord-261566-fn08b0y2	294	5	designing	design	VBG
cord-261566-fn08b0y2	294	6	and	and	CC
cord-261566-fn08b0y2	294	7	developing	develop	VBG
cord-261566-fn08b0y2	294	8	vaccines	vaccine	NNS
cord-261566-fn08b0y2	294	9	,	,	,
cord-261566-fn08b0y2	294	10	immunotherapeutics	immunotherapeutic	NNS
cord-261566-fn08b0y2	294	11	,	,	,
cord-261566-fn08b0y2	294	12	and	and	CC
cord-261566-fn08b0y2	294	13	therapeutics	therapeutic	NNS
cord-261566-fn08b0y2	294	14	In	in	IN
cord-261566-fn08b0y2	294	15	silico	silico	NNS
cord-261566-fn08b0y2	294	16	guided	guide	VBN
cord-261566-fn08b0y2	294	17	drug	drug	NN
cord-261566-fn08b0y2	294	18	repurposing	repurposing	NN
cord-261566-fn08b0y2	294	19	to	to	TO
cord-261566-fn08b0y2	294	20	combat	combat	VB
cord-261566-fn08b0y2	294	21	SARS	SARS	NNP
cord-261566-fn08b0y2	294	22	-	-	HYPH
cord-261566-fn08b0y2	294	23	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	294	24	by	by	IN
cord-261566-fn08b0y2	294	25	Targeting	Targeting	NNP
cord-261566-fn08b0y2	294	26	Mpro	Mpro	NNP
cord-261566-fn08b0y2	294	27	,	,	,
cord-261566-fn08b0y2	294	28	the	the	DT
cord-261566-fn08b0y2	294	29	key	key	JJ
cord-261566-fn08b0y2	294	30	virus	virus	NN
cord-261566-fn08b0y2	294	31	specific	specific	JJ
cord-261566-fn08b0y2	294	32	protease	protease	NN
cord-261566-fn08b0y2	294	33	Tomar	Tomar	NNP
cord-261566-fn08b0y2	294	34	S	S	NNP
cord-261566-fn08b0y2	294	35	Identification	Identification	NNP
cord-261566-fn08b0y2	294	36	of	of	IN
cord-261566-fn08b0y2	294	37	SARS	SARS	NNP
cord-261566-fn08b0y2	294	38	-	-	HYPH
cord-261566-fn08b0y2	294	39	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	294	40	cell	cell	NN
cord-261566-fn08b0y2	294	41	entry	entry	NN
cord-261566-fn08b0y2	294	42	inhibitors	inhibitor	NNS
cord-261566-fn08b0y2	294	43	by	by	IN
cord-261566-fn08b0y2	294	44	drug	drug	NN
cord-261566-fn08b0y2	294	45	repurposing	repurposing	NN
cord-261566-fn08b0y2	294	46	using	use	VBG
cord-261566-fn08b0y2	294	47	in	in	IN
cord-261566-fn08b0y2	294	48	silico	silico	NN
cord-261566-fn08b0y2	294	49	structure	structure	NN
cord-261566-fn08b0y2	294	50	-	-	HYPH
cord-261566-fn08b0y2	294	51	based	base	VBN
cord-261566-fn08b0y2	294	52	virtual	virtual	JJ
cord-261566-fn08b0y2	294	53	screening	screening	NN
cord-261566-fn08b0y2	294	54	approach	approach	NN
cord-261566-fn08b0y2	295	1	SARS	SARS	NNP
cord-261566-fn08b0y2	295	2	-	-	HYPH
cord-261566-fn08b0y2	295	3	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	295	4	E	e	NN
cord-261566-fn08b0y2	295	5	protein	protein	NN
cord-261566-fn08b0y2	295	6	is	be	VBZ
cord-261566-fn08b0y2	295	7	a	a	DT
cord-261566-fn08b0y2	295	8	potential	potential	JJ
cord-261566-fn08b0y2	295	9	ion	ion	NN
cord-261566-fn08b0y2	295	10	channel	channel	NN
cord-261566-fn08b0y2	295	11	that	that	WDT
cord-261566-fn08b0y2	295	12	can	can	MD
cord-261566-fn08b0y2	295	13	Be	be	VB
cord-261566-fn08b0y2	295	14	inhibited	inhibit	VBN
cord-261566-fn08b0y2	295	15	by	by	IN
cord-261566-fn08b0y2	295	16	Gliclazide	Gliclazide	NNP
cord-261566-fn08b0y2	295	17	and	and	CC
cord-261566-fn08b0y2	295	18	Memantine	Memantine	NNP
cord-261566-fn08b0y2	295	19	Immune	Immune	NNP
cord-261566-fn08b0y2	295	20	response	response	NN
cord-261566-fn08b0y2	295	21	of	of	IN
cord-261566-fn08b0y2	295	22	sows	sow	NNS
cord-261566-fn08b0y2	295	23	vaccinated	vaccinate	VBN
cord-261566-fn08b0y2	295	24	with	with	IN
cord-261566-fn08b0y2	295	25	attenuated	attenuated	JJ
cord-261566-fn08b0y2	295	26	transmissible	transmissible	JJ
cord-261566-fn08b0y2	295	27	gastroenteritis	gastroenteritis	NN
cord-261566-fn08b0y2	295	28	virus	virus	NN
cord-261566-fn08b0y2	295	29	(	(	-LRB-
cord-261566-fn08b0y2	295	30	TGEV	TGEV	NNP
cord-261566-fn08b0y2	295	31	)	)	-RRB-
cord-261566-fn08b0y2	295	32	and	and	CC
cord-261566-fn08b0y2	295	33	recombinant	recombinant	JJ
cord-261566-fn08b0y2	295	34	TGEV	TGEV	NNP
cord-261566-fn08b0y2	295	35	spike	spike	NN
cord-261566-fn08b0y2	295	36	protein	protein	NN
cord-261566-fn08b0y2	295	37	vaccines	vaccine	NNS
cord-261566-fn08b0y2	295	38	and	and	CC
cord-261566-fn08b0y2	295	39	protection	protection	NN
cord-261566-fn08b0y2	295	40	of	of	IN
cord-261566-fn08b0y2	295	41	their	-PRON-	PRP$
cord-261566-fn08b0y2	295	42	suckling	suckle	VBG
cord-261566-fn08b0y2	295	43	pigs	pig	NNS
cord-261566-fn08b0y2	295	44	against	against	IN
cord-261566-fn08b0y2	295	45	virulent	virulent	JJ
cord-261566-fn08b0y2	295	46	TGEV	TGEV	NNP
cord-261566-fn08b0y2	295	47	challenge	challenge	NN
cord-261566-fn08b0y2	295	48	exposure	exposure	NN
cord-261566-fn08b0y2	296	1	Recent	recent	JJ
cord-261566-fn08b0y2	296	2	progress	progress	NN
cord-261566-fn08b0y2	296	3	in	in	IN
cord-261566-fn08b0y2	296	4	mucosal	mucosal	JJ
cord-261566-fn08b0y2	296	5	vaccine	vaccine	NN
cord-261566-fn08b0y2	296	6	development	development	NN
cord-261566-fn08b0y2	296	7	:	:	:
cord-261566-fn08b0y2	296	8	potential	potential	NN
cord-261566-fn08b0y2	296	9	and	and	CC
cord-261566-fn08b0y2	296	10	limitations	limitation	NNS
cord-261566-fn08b0y2	296	11	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	296	12	vaccines	vaccine	NNS
cord-261566-fn08b0y2	296	13	:	:	:
cord-261566-fn08b0y2	296	14	strategies	strategy	NNS
cord-261566-fn08b0y2	296	15	and	and	CC
cord-261566-fn08b0y2	296	16	challenges	challenge	VBZ
cord-261566-fn08b0y2	296	17	The	the	DT
cord-261566-fn08b0y2	296	18	Severe	severe	JJ
cord-261566-fn08b0y2	296	19	Acute	acute	JJ
cord-261566-fn08b0y2	296	20	Respiratory	Respiratory	NNP
cord-261566-fn08b0y2	296	21	Syndrome	Syndrome	NNP
cord-261566-fn08b0y2	296	22	Functional	functional	JJ
cord-261566-fn08b0y2	296	23	assessment	assessment	NN
cord-261566-fn08b0y2	296	24	of	of	IN
cord-261566-fn08b0y2	296	25	cell	cell	NN
cord-261566-fn08b0y2	296	26	entry	entry	NN
cord-261566-fn08b0y2	296	27	and	and	CC
cord-261566-fn08b0y2	296	28	receptor	receptor	NN
cord-261566-fn08b0y2	296	29	usage	usage	NN
cord-261566-fn08b0y2	296	30	for	for	IN
cord-261566-fn08b0y2	296	31	SARS	SARS	NNP
cord-261566-fn08b0y2	296	32	-	-	HYPH
cord-261566-fn08b0y2	296	33	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	296	34	and	and	CC
cord-261566-fn08b0y2	296	35	other	other	JJ
cord-261566-fn08b0y2	296	36	lineage	lineage	NN
cord-261566-fn08b0y2	296	37	B	b	NN
cord-261566-fn08b0y2	296	38	betacoronaviruses	betacoronaviruses	NNP
cord-261566-fn08b0y2	297	1	Structural	structural	JJ
cord-261566-fn08b0y2	297	2	basis	basis	NN
cord-261566-fn08b0y2	297	3	of	of	IN
cord-261566-fn08b0y2	297	4	receptor	receptor	NN
cord-261566-fn08b0y2	297	5	recognition	recognition	NN
cord-261566-fn08b0y2	297	6	by	by	IN
cord-261566-fn08b0y2	297	7	SARS	SARS	NNP
cord-261566-fn08b0y2	297	8	-	-	HYPH
cord-261566-fn08b0y2	297	9	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	297	10	.	.	.
cord-261566-fn08b0y2	298	1	Nature	nature	NN
cord-261566-fn08b0y2	298	2	.	.	.
cord-261566-fn08b0y2	299	1	2020	2020	CD
cord-261566-fn08b0y2	299	2	SARS	SARS	NNP
cord-261566-fn08b0y2	299	3	-	-	HYPH
cord-261566-fn08b0y2	299	4	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	299	5	cell	cell	NN
cord-261566-fn08b0y2	299	6	entry	entry	NN
cord-261566-fn08b0y2	299	7	depends	depend	VBZ
cord-261566-fn08b0y2	299	8	on	on	IN
cord-261566-fn08b0y2	299	9	ACE2	ACE2	NNP
cord-261566-fn08b0y2	299	10	and	and	CC
cord-261566-fn08b0y2	299	11	TMPRSS2	TMPRSS2	NNP
cord-261566-fn08b0y2	299	12	and	and	CC
cord-261566-fn08b0y2	299	13	is	be	VBZ
cord-261566-fn08b0y2	299	14	blocked	block	VBN
cord-261566-fn08b0y2	299	15	by	by	IN
cord-261566-fn08b0y2	299	16	a	a	DT
cord-261566-fn08b0y2	299	17	clinically	clinically	RB
cord-261566-fn08b0y2	299	18	proven	prove	VBN
cord-261566-fn08b0y2	299	19	protease	protease	NN
cord-261566-fn08b0y2	299	20	inhibitor	inhibitor	NN
cord-261566-fn08b0y2	299	21	Tissue	tissue	NN
cord-261566-fn08b0y2	299	22	distribution	distribution	NN
cord-261566-fn08b0y2	299	23	of	of	IN
cord-261566-fn08b0y2	299	24	ACE2	ACE2	NNP
cord-261566-fn08b0y2	299	25	protein	protein	NN
cord-261566-fn08b0y2	299	26	,	,	,
cord-261566-fn08b0y2	299	27	the	the	DT
cord-261566-fn08b0y2	299	28	functional	functional	JJ
cord-261566-fn08b0y2	299	29	receptor	receptor	NN
cord-261566-fn08b0y2	299	30	for	for	IN
cord-261566-fn08b0y2	299	31	SARS	SARS	NNP
cord-261566-fn08b0y2	299	32	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	299	33	.	.	.
cord-261566-fn08b0y2	300	1	A	a	DT
cord-261566-fn08b0y2	300	2	first	first	JJ
cord-261566-fn08b0y2	300	3	step	step	NN
cord-261566-fn08b0y2	300	4	in	in	IN
cord-261566-fn08b0y2	300	5	understanding	understand	VBG
cord-261566-fn08b0y2	300	6	SARS	SARS	NNP
cord-261566-fn08b0y2	300	7	pathogenesis	pathogenesis	NN
cord-261566-fn08b0y2	301	1	Prolonged	prolonged	JJ
cord-261566-fn08b0y2	301	2	presence	presence	NN
cord-261566-fn08b0y2	301	3	of	of	IN
cord-261566-fn08b0y2	301	4	SARS	SARS	NNP
cord-261566-fn08b0y2	301	5	-	-	HYPH
cord-261566-fn08b0y2	301	6	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	301	7	viral	viral	JJ
cord-261566-fn08b0y2	301	8	RNA	rna	NN
cord-261566-fn08b0y2	301	9	in	in	IN
cord-261566-fn08b0y2	301	10	faecal	faecal	JJ
cord-261566-fn08b0y2	301	11	samples	sample	NNS
cord-261566-fn08b0y2	301	12	Detection	Detection	NNP
cord-261566-fn08b0y2	301	13	of	of	IN
cord-261566-fn08b0y2	301	14	SARS	SARS	NNP
cord-261566-fn08b0y2	301	15	-	-	HYPH
cord-261566-fn08b0y2	301	16	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	301	17	in	in	IN
cord-261566-fn08b0y2	301	18	Different	different	JJ
cord-261566-fn08b0y2	301	19	Types	type	NNS
cord-261566-fn08b0y2	301	20	of	of	IN
cord-261566-fn08b0y2	301	21	Clinical	clinical	JJ
cord-261566-fn08b0y2	301	22	Specimens	Specimens	NNP
cord-261566-fn08b0y2	301	23	Enteric	enteric	JJ
cord-261566-fn08b0y2	301	24	involvement	involvement	NN
cord-261566-fn08b0y2	301	25	of	of	IN
cord-261566-fn08b0y2	301	26	severe	severe	JJ
cord-261566-fn08b0y2	301	27	acute	acute	JJ
cord-261566-fn08b0y2	301	28	respiratory	respiratory	JJ
cord-261566-fn08b0y2	301	29	syndrome	syndrome	NN
cord-261566-fn08b0y2	301	30	-	-	HYPH
cord-261566-fn08b0y2	301	31	associated	associate	VBN
cord-261566-fn08b0y2	301	32	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	301	33	infection	infection	NN
cord-261566-fn08b0y2	302	1	Intranasal	intranasal	NN
cord-261566-fn08b0y2	302	2	immunization	immunization	NN
cord-261566-fn08b0y2	302	3	with	with	IN
cord-261566-fn08b0y2	302	4	inactivated	inactivate	VBN
cord-261566-fn08b0y2	302	5	SARS	SARS	NNP
cord-261566-fn08b0y2	302	6	-	-	HYPH
cord-261566-fn08b0y2	302	7	CoV	CoV	NNP
cord-261566-fn08b0y2	302	8	(	(	-LRB-
cord-261566-fn08b0y2	302	9	SARS	SARS	NNP
cord-261566-fn08b0y2	302	10	-	-	HYPH
cord-261566-fn08b0y2	302	11	associated	associate	VBN
cord-261566-fn08b0y2	302	12	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	302	13	)	)	-RRB-
cord-261566-fn08b0y2	302	14	induced	induce	VBN
cord-261566-fn08b0y2	302	15	local	local	JJ
cord-261566-fn08b0y2	302	16	and	and	CC
cord-261566-fn08b0y2	302	17	serum	serum	NN
cord-261566-fn08b0y2	302	18	antibodies	antibody	NNS
cord-261566-fn08b0y2	302	19	in	in	IN
cord-261566-fn08b0y2	302	20	mice	mouse	NNS
cord-261566-fn08b0y2	303	1	Intranasal	intranasal	NN
cord-261566-fn08b0y2	303	2	vaccination	vaccination	NN
cord-261566-fn08b0y2	303	3	with	with	IN
cord-261566-fn08b0y2	303	4	recombinant	recombinant	JJ
cord-261566-fn08b0y2	303	5	receptor	receptor	NN
cord-261566-fn08b0y2	303	6	-	-	HYPH
cord-261566-fn08b0y2	303	7	binding	bind	VBG
cord-261566-fn08b0y2	303	8	domain	domain	NN
cord-261566-fn08b0y2	303	9	of	of	IN
cord-261566-fn08b0y2	303	10	MERS	MERS	NNP
cord-261566-fn08b0y2	303	11	-	-	HYPH
cord-261566-fn08b0y2	303	12	CoV	CoV	NNP
cord-261566-fn08b0y2	303	13	spike	spike	NN
cord-261566-fn08b0y2	303	14	protein	protein	NN
cord-261566-fn08b0y2	303	15	induces	induce	VBZ
cord-261566-fn08b0y2	303	16	much	much	RB
cord-261566-fn08b0y2	303	17	stronger	strong	JJR
cord-261566-fn08b0y2	303	18	local	local	JJ
cord-261566-fn08b0y2	303	19	mucosal	mucosal	JJ
cord-261566-fn08b0y2	303	20	immune	immune	JJ
cord-261566-fn08b0y2	303	21	responses	response	NNS
cord-261566-fn08b0y2	303	22	than	than	IN
cord-261566-fn08b0y2	303	23	subcutaneous	subcutaneous	JJ
cord-261566-fn08b0y2	303	24	immunization	immunization	NN
cord-261566-fn08b0y2	303	25	:	:	:
cord-261566-fn08b0y2	303	26	implication	implication	NN
cord-261566-fn08b0y2	303	27	for	for	IN
cord-261566-fn08b0y2	303	28	designing	design	VBG
cord-261566-fn08b0y2	303	29	novel	novel	JJ
cord-261566-fn08b0y2	303	30	mucosal	mucosal	JJ
cord-261566-fn08b0y2	303	31	MERS	MERS	NNP
cord-261566-fn08b0y2	303	32	vaccines	vaccine	NNS
cord-261566-fn08b0y2	304	1	The	the	DT
cord-261566-fn08b0y2	304	2	mucosal	mucosal	JJ
cord-261566-fn08b0y2	304	3	immune	immune	JJ
cord-261566-fn08b0y2	304	4	system	system	NN
cord-261566-fn08b0y2	304	5	:	:	:
cord-261566-fn08b0y2	304	6	from	from	IN
cord-261566-fn08b0y2	304	7	fundamental	fundamental	JJ
cord-261566-fn08b0y2	304	8	concepts	concept	NNS
cord-261566-fn08b0y2	304	9	to	to	TO
cord-261566-fn08b0y2	304	10	vaccine	vaccine	VB
cord-261566-fn08b0y2	304	11	development	development	NN
cord-261566-fn08b0y2	304	12	Immunity	immunity	NN
cord-261566-fn08b0y2	304	13	against	against	IN
cord-261566-fn08b0y2	304	14	mucosal	mucosal	JJ
cord-261566-fn08b0y2	304	15	pathogens	pathogen	NNS
cord-261566-fn08b0y2	305	1	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	305	2	dendritic	dendritic	JJ
cord-261566-fn08b0y2	305	3	cells	cell	NNS
cord-261566-fn08b0y2	306	1	Antiviral	antiviral	JJ
cord-261566-fn08b0y2	306	2	immune	immune	JJ
cord-261566-fn08b0y2	306	3	responses	response	NNS
cord-261566-fn08b0y2	306	4	in	in	IN
cord-261566-fn08b0y2	306	5	the	the	DT
cord-261566-fn08b0y2	306	6	genital	genital	JJ
cord-261566-fn08b0y2	306	7	tract	tract	NN
cord-261566-fn08b0y2	306	8	:	:	:
cord-261566-fn08b0y2	306	9	clues	clue	NNS
cord-261566-fn08b0y2	306	10	for	for	IN
cord-261566-fn08b0y2	306	11	vaccines	vaccine	NNS
cord-261566-fn08b0y2	306	12	Normal	normal	JJ
cord-261566-fn08b0y2	306	13	structure	structure	NN
cord-261566-fn08b0y2	306	14	,	,	,
cord-261566-fn08b0y2	306	15	function	function	NN
cord-261566-fn08b0y2	306	16	,	,	,
cord-261566-fn08b0y2	306	17	and	and	CC
cord-261566-fn08b0y2	306	18	histology	histology	NN
cord-261566-fn08b0y2	306	19	of	of	IN
cord-261566-fn08b0y2	306	20	mucosa	mucosa	NN
cord-261566-fn08b0y2	306	21	-	-	HYPH
cord-261566-fn08b0y2	306	22	associated	associate	VBN
cord-261566-fn08b0y2	306	23	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	306	24	tissue	tissue	NN
cord-261566-fn08b0y2	306	25	Terminology	terminology	NN
cord-261566-fn08b0y2	306	26	:	:	:
cord-261566-fn08b0y2	306	27	nomenclature	nomenclature	NN
cord-261566-fn08b0y2	306	28	of	of	IN
cord-261566-fn08b0y2	306	29	mucosa	mucosa	NN
cord-261566-fn08b0y2	306	30	-	-	HYPH
cord-261566-fn08b0y2	306	31	associated	associate	VBN
cord-261566-fn08b0y2	306	32	lymphoid	lymphoid	JJ
cord-261566-fn08b0y2	306	33	tissue	tissue	NN
cord-261566-fn08b0y2	306	34	Interactions	interaction	NNS
cord-261566-fn08b0y2	306	35	of	of	IN
cord-261566-fn08b0y2	306	36	the	the	DT
cord-261566-fn08b0y2	306	37	Invasive	Invasive	NNP
cord-261566-fn08b0y2	306	38	PathogensSalmonella	PathogensSalmonella	NNP
cord-261566-fn08b0y2	306	39	typhimurium	typhimurium	NN
cord-261566-fn08b0y2	306	40	,	,	,
cord-261566-fn08b0y2	306	41	Listeria	Listeria	NNP
cord-261566-fn08b0y2	306	42	monocytogenes	monocytogenes	NNP
cord-261566-fn08b0y2	306	43	,	,	,
cord-261566-fn08b0y2	306	44	and	and	CC
cord-261566-fn08b0y2	306	45	Shigella	Shigella	NNP
cord-261566-fn08b0y2	306	46	flexneri	flexneri	NN
cord-261566-fn08b0y2	306	47	with	with	IN
cord-261566-fn08b0y2	306	48	M	M	NNP
cord-261566-fn08b0y2	306	49	Cells	Cells	NNPS
cord-261566-fn08b0y2	306	50	and	and	CC
cord-261566-fn08b0y2	306	51	Murine	Murine	NNP
cord-261566-fn08b0y2	306	52	Peyer	Peyer	NNP
cord-261566-fn08b0y2	306	53	's	's	POS
cord-261566-fn08b0y2	306	54	Patches	Patches	NNPS
cord-261566-fn08b0y2	306	55	Intestinal	intestinal	JJ
cord-261566-fn08b0y2	306	56	villous	villous	NN
cord-261566-fn08b0y2	306	57	M	m	CD
cord-261566-fn08b0y2	306	58	cells	cell	NNS
cord-261566-fn08b0y2	306	59	:	:	:
cord-261566-fn08b0y2	306	60	an	an	DT
cord-261566-fn08b0y2	306	61	antigen	antigen	NN
cord-261566-fn08b0y2	306	62	entry	entry	NN
cord-261566-fn08b0y2	306	63	site	site	NN
cord-261566-fn08b0y2	306	64	in	in	IN
cord-261566-fn08b0y2	306	65	the	the	DT
cord-261566-fn08b0y2	306	66	mucosal	mucosal	JJ
cord-261566-fn08b0y2	306	67	epithelium	epithelium	NN
cord-261566-fn08b0y2	306	68	Induction	Induction	NNP
cord-261566-fn08b0y2	306	69	of	of	IN
cord-261566-fn08b0y2	306	70	gut	gut	NN
cord-261566-fn08b0y2	306	71	IgA	IgA	NNP
cord-261566-fn08b0y2	306	72	production	production	NN
cord-261566-fn08b0y2	306	73	through	through	IN
cord-261566-fn08b0y2	306	74	T	T	NNP
cord-261566-fn08b0y2	306	75	cell	cell	NN
cord-261566-fn08b0y2	306	76	-	-	HYPH
cord-261566-fn08b0y2	306	77	dependent	dependent	JJ
cord-261566-fn08b0y2	306	78	and	and	CC
cord-261566-fn08b0y2	306	79	T	t	NN
cord-261566-fn08b0y2	306	80	cell	cell	NN
cord-261566-fn08b0y2	306	81	-	-	HYPH
cord-261566-fn08b0y2	306	82	independent	independent	JJ
cord-261566-fn08b0y2	306	83	pathways	pathway	NNS
cord-261566-fn08b0y2	307	1	New	new	JJ
cord-261566-fn08b0y2	307	2	concepts	concept	NNS
cord-261566-fn08b0y2	307	3	in	in	IN
cord-261566-fn08b0y2	307	4	the	the	DT
cord-261566-fn08b0y2	307	5	generation	generation	NN
cord-261566-fn08b0y2	307	6	and	and	CC
cord-261566-fn08b0y2	307	7	functions	function	NNS
cord-261566-fn08b0y2	307	8	of	of	IN
cord-261566-fn08b0y2	307	9	IgA	IgA	NNP
cord-261566-fn08b0y2	308	1	The	the	DT
cord-261566-fn08b0y2	308	2	role	role	NN
cord-261566-fn08b0y2	308	3	of	of	IN
cord-261566-fn08b0y2	308	4	secretory	secretory	JJ
cord-261566-fn08b0y2	308	5	antibodies	antibody	NNS
cord-261566-fn08b0y2	308	6	in	in	IN
cord-261566-fn08b0y2	308	7	infection	infection	NN
cord-261566-fn08b0y2	308	8	immunity	immunity	NN
cord-261566-fn08b0y2	308	9	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	308	10	immunity	immunity	NN
cord-261566-fn08b0y2	308	11	and	and	CC
cord-261566-fn08b0y2	308	12	vaccines	vaccine	NNS
cord-261566-fn08b0y2	309	1	Recent	recent	JJ
cord-261566-fn08b0y2	309	2	advances	advance	NNS
cord-261566-fn08b0y2	309	3	in	in	IN
cord-261566-fn08b0y2	309	4	the	the	DT
cord-261566-fn08b0y2	309	5	vaccine	vaccine	NN
cord-261566-fn08b0y2	309	6	development	development	NN
cord-261566-fn08b0y2	309	7	against	against	IN
cord-261566-fn08b0y2	309	8	middle	middle	NNP
cord-261566-fn08b0y2	309	9	east	east	NNP
cord-261566-fn08b0y2	309	10	respiratory	respiratory	JJ
cord-261566-fn08b0y2	309	11	syndrome	syndrome	NN
cord-261566-fn08b0y2	309	12	-	-	HYPH
cord-261566-fn08b0y2	309	13	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	310	1	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	310	2	Vaccine	Vaccine	NNP
cord-261566-fn08b0y2	310	3	Design	Design	NNP
cord-261566-fn08b0y2	310	4	and	and	CC
cord-261566-fn08b0y2	310	5	Delivery	Delivery	NNP
cord-261566-fn08b0y2	310	6	DNA	DNA	NNP
cord-261566-fn08b0y2	310	7	vaccines	vaccine	NNS
cord-261566-fn08b0y2	310	8	:	:	:
cord-261566-fn08b0y2	310	9	a	a	DT
cord-261566-fn08b0y2	310	10	key	key	NN
cord-261566-fn08b0y2	310	11	for	for	IN
cord-261566-fn08b0y2	310	12	inducing	induce	VBG
cord-261566-fn08b0y2	310	13	long	long	JJ
cord-261566-fn08b0y2	310	14	-	-	HYPH
cord-261566-fn08b0y2	310	15	term	term	NN
cord-261566-fn08b0y2	310	16	cellular	cellular	JJ
cord-261566-fn08b0y2	310	17	immunity	immunity	NN
cord-261566-fn08b0y2	310	18	Recombinant	recombinant	JJ
cord-261566-fn08b0y2	310	19	viruses	virus	NNS
cord-261566-fn08b0y2	310	20	as	as	IN
cord-261566-fn08b0y2	310	21	tools	tool	NNS
cord-261566-fn08b0y2	310	22	to	to	TO
cord-261566-fn08b0y2	310	23	induce	induce	VB
cord-261566-fn08b0y2	310	24	protective	protective	JJ
cord-261566-fn08b0y2	310	25	cellular	cellular	JJ
cord-261566-fn08b0y2	310	26	immunity	immunity	NN
cord-261566-fn08b0y2	310	27	against	against	IN
cord-261566-fn08b0y2	310	28	infectious	infectious	JJ
cord-261566-fn08b0y2	310	29	diseases	disease	NNS
cord-261566-fn08b0y2	310	30	Modern	modern	JJ
cord-261566-fn08b0y2	310	31	subunit	subunit	NN
cord-261566-fn08b0y2	310	32	vaccines	vaccine	NNS
cord-261566-fn08b0y2	310	33	:	:	:
cord-261566-fn08b0y2	310	34	development	development	NN
cord-261566-fn08b0y2	310	35	,	,	,
cord-261566-fn08b0y2	310	36	components	component	NNS
cord-261566-fn08b0y2	310	37	,	,	,
cord-261566-fn08b0y2	310	38	and	and	CC
cord-261566-fn08b0y2	310	39	research	research	NN
cord-261566-fn08b0y2	310	40	opportunities	opportunity	NNS
cord-261566-fn08b0y2	311	1	Comparative	comparative	JJ
cord-261566-fn08b0y2	311	2	evaluation	evaluation	NN
cord-261566-fn08b0y2	311	3	of	of	IN
cord-261566-fn08b0y2	311	4	two	two	CD
cord-261566-fn08b0y2	311	5	severe	severe	JJ
cord-261566-fn08b0y2	311	6	acute	acute	JJ
cord-261566-fn08b0y2	311	7	respiratory	respiratory	JJ
cord-261566-fn08b0y2	311	8	syndrome	syndrome	NN
cord-261566-fn08b0y2	311	9	(	(	-LRB-
cord-261566-fn08b0y2	311	10	SARS	SARS	NNP
cord-261566-fn08b0y2	311	11	)	)	-RRB-
cord-261566-fn08b0y2	311	12	vaccine	vaccine	NN
cord-261566-fn08b0y2	311	13	candidates	candidate	NNS
cord-261566-fn08b0y2	311	14	in	in	IN
cord-261566-fn08b0y2	311	15	mice	mouse	NNS
cord-261566-fn08b0y2	311	16	challenged	challenge	VBN
cord-261566-fn08b0y2	311	17	with	with	IN
cord-261566-fn08b0y2	311	18	SARS	SARS	NNP
cord-261566-fn08b0y2	311	19	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	311	20	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	311	21	immunisation	immunisation	NN
cord-261566-fn08b0y2	311	22	of	of	IN
cord-261566-fn08b0y2	311	23	African	african	JJ
cord-261566-fn08b0y2	311	24	green	green	JJ
cord-261566-fn08b0y2	311	25	monkeys	monkey	NNS
cord-261566-fn08b0y2	311	26	(	(	-LRB-
cord-261566-fn08b0y2	311	27	Cercopithecus	Cercopithecus	NNP
cord-261566-fn08b0y2	311	28	aethiops	aethiop	NNS
cord-261566-fn08b0y2	311	29	)	)	-RRB-
cord-261566-fn08b0y2	311	30	with	with	IN
cord-261566-fn08b0y2	311	31	an	an	DT
cord-261566-fn08b0y2	311	32	attenuated	attenuated	JJ
cord-261566-fn08b0y2	311	33	parainfluenza	parainfluenza	NNP
cord-261566-fn08b0y2	311	34	virus	virus	NN
cord-261566-fn08b0y2	311	35	expressing	express	VBG
cord-261566-fn08b0y2	311	36	the	the	DT
cord-261566-fn08b0y2	311	37	SARS	SARS	NNP
cord-261566-fn08b0y2	311	38	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	311	39	spike	spike	NN
cord-261566-fn08b0y2	311	40	protein	protein	NN
cord-261566-fn08b0y2	311	41	for	for	IN
cord-261566-fn08b0y2	311	42	the	the	DT
cord-261566-fn08b0y2	311	43	prevention	prevention	NN
cord-261566-fn08b0y2	311	44	of	of	IN
cord-261566-fn08b0y2	311	45	SARS	SARS	NNP
cord-261566-fn08b0y2	311	46	Intranasal	Intranasal	NNP
cord-261566-fn08b0y2	311	47	vaccination	vaccination	NN
cord-261566-fn08b0y2	311	48	of	of	IN
cord-261566-fn08b0y2	311	49	recombinant	recombinant	JJ
cord-261566-fn08b0y2	311	50	adeno	adeno	NN
cord-261566-fn08b0y2	311	51	-	-	HYPH
cord-261566-fn08b0y2	311	52	associated	associate	VBN
cord-261566-fn08b0y2	311	53	virus	virus	NN
cord-261566-fn08b0y2	311	54	encoding	encode	VBG
cord-261566-fn08b0y2	311	55	receptor	receptor	NN
cord-261566-fn08b0y2	311	56	-	-	HYPH
cord-261566-fn08b0y2	311	57	binding	bind	VBG
cord-261566-fn08b0y2	311	58	domain	domain	NN
cord-261566-fn08b0y2	311	59	of	of	IN
cord-261566-fn08b0y2	311	60	severe	severe	JJ
cord-261566-fn08b0y2	311	61	acute	acute	JJ
cord-261566-fn08b0y2	311	62	respiratory	respiratory	JJ
cord-261566-fn08b0y2	311	63	syndrome	syndrome	NN
cord-261566-fn08b0y2	311	64	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	311	65	(	(	-LRB-
cord-261566-fn08b0y2	311	66	SARS	SARS	NNP
cord-261566-fn08b0y2	311	67	-	-	HYPH
cord-261566-fn08b0y2	311	68	CoV	CoV	NNP
cord-261566-fn08b0y2	311	69	)	)	-RRB-
cord-261566-fn08b0y2	312	1	spike	spike	NN
cord-261566-fn08b0y2	312	2	protein	protein	NN
cord-261566-fn08b0y2	312	3	induces	induce	VBZ
cord-261566-fn08b0y2	312	4	strong	strong	JJ
cord-261566-fn08b0y2	312	5	mucosal	mucosal	JJ
cord-261566-fn08b0y2	312	6	immune	immune	JJ
cord-261566-fn08b0y2	312	7	responses	response	NNS
cord-261566-fn08b0y2	312	8	and	and	CC
cord-261566-fn08b0y2	312	9	provides	provide	VBZ
cord-261566-fn08b0y2	312	10	long	long	JJ
cord-261566-fn08b0y2	312	11	-	-	HYPH
cord-261566-fn08b0y2	312	12	term	term	NN
cord-261566-fn08b0y2	312	13	protection	protection	NN
cord-261566-fn08b0y2	312	14	against	against	IN
cord-261566-fn08b0y2	312	15	SARS	SARS	NNP
cord-261566-fn08b0y2	312	16	-	-	HYPH
cord-261566-fn08b0y2	312	17	CoV	CoV	NNP
cord-261566-fn08b0y2	312	18	infection	infection	NN
cord-261566-fn08b0y2	312	19	Singledose	Singledose	NNP
cord-261566-fn08b0y2	312	20	,	,	,
cord-261566-fn08b0y2	312	21	intranasal	intranasal	NN
cord-261566-fn08b0y2	312	22	immunization	immunization	NN
cord-261566-fn08b0y2	312	23	with	with	IN
cord-261566-fn08b0y2	312	24	recombinant	recombinant	JJ
cord-261566-fn08b0y2	312	25	parainfluenza	parainfluenza	NNP
cord-261566-fn08b0y2	312	26	virus	virus	NNP
cord-261566-fn08b0y2	312	27	5	5	CD
cord-261566-fn08b0y2	312	28	expressing	express	VBG
cord-261566-fn08b0y2	312	29	middle	middle	NNP
cord-261566-fn08b0y2	312	30	east	east	NNP
cord-261566-fn08b0y2	312	31	respiratory	respiratory	JJ
cord-261566-fn08b0y2	312	32	syndrome	syndrome	NN
cord-261566-fn08b0y2	312	33	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	312	34	(	(	-LRB-
cord-261566-fn08b0y2	312	35	MERS	MERS	NNP
cord-261566-fn08b0y2	312	36	-	-	HYPH
cord-261566-fn08b0y2	312	37	CoV	CoV	NNP
cord-261566-fn08b0y2	312	38	)	)	-RRB-
cord-261566-fn08b0y2	313	1	Spike	spike	NN
cord-261566-fn08b0y2	313	2	protein	protein	NN
cord-261566-fn08b0y2	313	3	protects	protect	VBZ
cord-261566-fn08b0y2	313	4	mice	mouse	NNS
cord-261566-fn08b0y2	313	5	from	from	IN
cord-261566-fn08b0y2	313	6	fatal	fatal	JJ
cord-261566-fn08b0y2	313	7	MERS	MERS	NNP
cord-261566-fn08b0y2	313	8	-	-	HYPH
cord-261566-fn08b0y2	313	9	CoV	CoV	NNP
cord-261566-fn08b0y2	313	10	infection	infection	NN
cord-261566-fn08b0y2	313	11	Single	single	JJ
cord-261566-fn08b0y2	313	12	intranasal	intranasal	NN
cord-261566-fn08b0y2	313	13	immunization	immunization	NN
cord-261566-fn08b0y2	313	14	with	with	IN
cord-261566-fn08b0y2	313	15	chimpanzee	chimpanzee	NN
cord-261566-fn08b0y2	313	16	adenovirus	adenovirus	NN
cord-261566-fn08b0y2	313	17	-	-	HYPH
cord-261566-fn08b0y2	313	18	based	base	VBN
cord-261566-fn08b0y2	313	19	vaccine	vaccine	NN
cord-261566-fn08b0y2	313	20	induces	induce	VBZ
cord-261566-fn08b0y2	313	21	sustained	sustained	JJ
cord-261566-fn08b0y2	313	22	and	and	CC
cord-261566-fn08b0y2	313	23	protective	protective	JJ
cord-261566-fn08b0y2	313	24	immunity	immunity	NN
cord-261566-fn08b0y2	313	25	against	against	IN
cord-261566-fn08b0y2	313	26	MERS	MERS	NNP
cord-261566-fn08b0y2	313	27	-	-	HYPH
cord-261566-fn08b0y2	313	28	CoV	CoV	NNP
cord-261566-fn08b0y2	313	29	infection	infection	NN
cord-261566-fn08b0y2	314	1	Superior	superior	JJ
cord-261566-fn08b0y2	314	2	immune	immune	JJ
cord-261566-fn08b0y2	314	3	responses	response	NNS
cord-261566-fn08b0y2	314	4	induced	induce	VBN
cord-261566-fn08b0y2	314	5	by	by	IN
cord-261566-fn08b0y2	314	6	intranasal	intranasal	NN
cord-261566-fn08b0y2	314	7	immunization	immunization	NN
cord-261566-fn08b0y2	314	8	with	with	IN
cord-261566-fn08b0y2	314	9	recombinant	recombinant	JJ
cord-261566-fn08b0y2	314	10	adenovirus	adenovirus	NN
cord-261566-fn08b0y2	314	11	-	-	HYPH
cord-261566-fn08b0y2	314	12	based	base	VBN
cord-261566-fn08b0y2	314	13	vaccine	vaccine	NN
cord-261566-fn08b0y2	314	14	expressing	express	VBG
cord-261566-fn08b0y2	314	15	full	full	JJ
cord-261566-fn08b0y2	314	16	-	-	HYPH
cord-261566-fn08b0y2	314	17	length	length	NN
cord-261566-fn08b0y2	314	18	Spike	Spike	NNP
cord-261566-fn08b0y2	314	19	protein	protein	NN
cord-261566-fn08b0y2	314	20	of	of	IN
cord-261566-fn08b0y2	314	21	Middle	Middle	NNP
cord-261566-fn08b0y2	314	22	East	East	NNP
cord-261566-fn08b0y2	314	23	respiratory	respiratory	JJ
cord-261566-fn08b0y2	314	24	syndrome	syndrome	NN
cord-261566-fn08b0y2	314	25	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	314	26	A	a	DT
cord-261566-fn08b0y2	314	27	recombinant	recombinant	JJ
cord-261566-fn08b0y2	314	28	VSV	VSV	NNP
cord-261566-fn08b0y2	314	29	-	-	HYPH
cord-261566-fn08b0y2	314	30	vectored	vectore	VBN
cord-261566-fn08b0y2	314	31	MERS	MERS	NNP
cord-261566-fn08b0y2	314	32	-	-	HYPH
cord-261566-fn08b0y2	314	33	CoV	CoV	NNP
cord-261566-fn08b0y2	314	34	vaccine	vaccine	NN
cord-261566-fn08b0y2	314	35	induces	induce	VBZ
cord-261566-fn08b0y2	314	36	neutralizing	neutralize	VBG
cord-261566-fn08b0y2	314	37	antibody	antibody	NN
cord-261566-fn08b0y2	314	38	and	and	CC
cord-261566-fn08b0y2	314	39	T	t	NN
cord-261566-fn08b0y2	314	40	cell	cell	NN
cord-261566-fn08b0y2	314	41	responses	response	NNS
cord-261566-fn08b0y2	314	42	in	in	IN
cord-261566-fn08b0y2	314	43	rhesus	rhesu	NNS
cord-261566-fn08b0y2	314	44	monkeys	monkey	NNS
cord-261566-fn08b0y2	314	45	after	after	IN
cord-261566-fn08b0y2	314	46	single	single	JJ
cord-261566-fn08b0y2	314	47	dose	dose	NN
cord-261566-fn08b0y2	314	48	immunization	immunization	NN
cord-261566-fn08b0y2	314	49	Expression	expression	NN
cord-261566-fn08b0y2	314	50	of	of	IN
cord-261566-fn08b0y2	314	51	SARS	SARS	NNP
cord-261566-fn08b0y2	314	52	-	-	HYPH
cord-261566-fn08b0y2	314	53	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	314	54	nucleocapsid	nucleocapsid	NN
cord-261566-fn08b0y2	314	55	protein	protein	NN
cord-261566-fn08b0y2	314	56	in	in	IN
cord-261566-fn08b0y2	314	57	Escherichia	Escherichia	NNP
cord-261566-fn08b0y2	314	58	coli	coli	NNS
cord-261566-fn08b0y2	314	59	and	and	CC
cord-261566-fn08b0y2	314	60	Lactococcus	Lactococcus	NNP
cord-261566-fn08b0y2	314	61	lactis	lactis	NNP
cord-261566-fn08b0y2	314	62	for	for	IN
cord-261566-fn08b0y2	314	63	serodiagnosis	serodiagnosis	NNP
cord-261566-fn08b0y2	314	64	and	and	CC
cord-261566-fn08b0y2	314	65	mucosal	mucosal	JJ
cord-261566-fn08b0y2	314	66	vaccination	vaccination	NN
cord-261566-fn08b0y2	314	67	Intranasal	Intranasal	NNP
cord-261566-fn08b0y2	314	68	immunization	immunization	NN
cord-261566-fn08b0y2	314	69	with	with	IN
cord-261566-fn08b0y2	314	70	plasmid	plasmid	NN
cord-261566-fn08b0y2	314	71	DNA	dna	NN
cord-261566-fn08b0y2	314	72	encoding	encoding	NN
cord-261566-fn08b0y2	314	73	spike	spike	NN
cord-261566-fn08b0y2	314	74	protein	protein	NN
cord-261566-fn08b0y2	314	75	of	of	IN
cord-261566-fn08b0y2	314	76	SARS	SARS	NNP
cord-261566-fn08b0y2	314	77	-	-	HYPH
cord-261566-fn08b0y2	314	78	coronavirus	coronavirus	NNP
cord-261566-fn08b0y2	314	79	/	/	SYM
cord-261566-fn08b0y2	314	80	polyethylenimine	polyethylenimine	NNP
cord-261566-fn08b0y2	314	81	nanoparticles	nanoparticle	NNS
cord-261566-fn08b0y2	314	82	elicits	elicit	VBZ
cord-261566-fn08b0y2	314	83	antigen	antigen	NN
cord-261566-fn08b0y2	314	84	-	-	HYPH
cord-261566-fn08b0y2	314	85	specific	specific	JJ
cord-261566-fn08b0y2	314	86	humoral	humoral	JJ
cord-261566-fn08b0y2	314	87	and	and	CC
cord-261566-fn08b0y2	314	88	cellular	cellular	JJ
cord-261566-fn08b0y2	314	89	immune	immune	JJ
cord-261566-fn08b0y2	314	90	responses	response	NNS
cord-261566-fn08b0y2	314	91	Dendritic	dendritic	JJ
cord-261566-fn08b0y2	314	92	cell	cell	NN
cord-261566-fn08b0y2	314	93	targeted	target	VBD
cord-261566-fn08b0y2	314	94	chitosan	chitosan	NN
cord-261566-fn08b0y2	314	95	nanoparticles	nanoparticle	NNS
cord-261566-fn08b0y2	314	96	for	for	IN
cord-261566-fn08b0y2	314	97	nasal	nasal	NN
cord-261566-fn08b0y2	314	98	DNA	dna	NN
cord-261566-fn08b0y2	314	99	immunization	immunization	NN
cord-261566-fn08b0y2	314	100	against	against	IN
cord-261566-fn08b0y2	314	101	SARS	SARS	NNP
cord-261566-fn08b0y2	314	102	CoV	CoV	NNP
cord-261566-fn08b0y2	314	103	nucleocapsid	nucleocapsid	NNP
cord-261566-fn08b0y2	314	104	protein	protein	NNP
cord-261566-fn08b0y2	314	105	Effect	Effect	NNP
cord-261566-fn08b0y2	314	106	of	of	IN
cord-261566-fn08b0y2	314	107	mucosal	mucosal	JJ
cord-261566-fn08b0y2	314	108	and	and	CC
cord-261566-fn08b0y2	314	109	systemic	systemic	JJ
cord-261566-fn08b0y2	314	110	immunization	immunization	NN
cord-261566-fn08b0y2	314	111	with	with	IN
cord-261566-fn08b0y2	314	112	virus	virus	NN
cord-261566-fn08b0y2	314	113	-	-	HYPH
cord-261566-fn08b0y2	314	114	like	like	JJ
cord-261566-fn08b0y2	314	115	particles	particle	NNS
cord-261566-fn08b0y2	314	116	of	of	IN
cord-261566-fn08b0y2	314	117	severe	severe	JJ
cord-261566-fn08b0y2	314	118	acute	acute	JJ
cord-261566-fn08b0y2	314	119	respiratory	respiratory	JJ
cord-261566-fn08b0y2	314	120	syndrome	syndrome	NN
cord-261566-fn08b0y2	314	121	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	314	122	in	in	IN
cord-261566-fn08b0y2	314	123	mice	mouse	NNS
cord-261566-fn08b0y2	315	1	Combination	combination	NN
cord-261566-fn08b0y2	315	2	Attenuation	attenuation	NN
cord-261566-fn08b0y2	315	3	Offers	offer	VBZ
cord-261566-fn08b0y2	315	4	Strategy	Strategy	NNP
cord-261566-fn08b0y2	315	5	for	for	IN
cord-261566-fn08b0y2	315	6	Live	live	JJ
cord-261566-fn08b0y2	315	7	Attenuated	attenuated	JJ
cord-261566-fn08b0y2	315	8	Coronavirus	Coronavirus	NNP
cord-261566-fn08b0y2	315	9	Vaccines	Vaccines	NNPS
cord-261566-fn08b0y2	315	10	Immunogenicity	Immunogenicity	NNP
cord-261566-fn08b0y2	315	11	and	and	CC
cord-261566-fn08b0y2	315	12	structures	structure	NNS
cord-261566-fn08b0y2	315	13	of	of	IN
cord-261566-fn08b0y2	315	14	a	a	DT
cord-261566-fn08b0y2	315	15	rationally	rationally	RB
cord-261566-fn08b0y2	315	16	designed	design	VBN
cord-261566-fn08b0y2	315	17	prefusion	prefusion	NN
cord-261566-fn08b0y2	315	18	MERS	MERS	NNP
cord-261566-fn08b0y2	315	19	-	-	HYPH
cord-261566-fn08b0y2	315	20	CoV	CoV	NNP
cord-261566-fn08b0y2	315	21	spike	spike	NN
cord-261566-fn08b0y2	315	22	antigen	antigen	NN
cord-261566-fn08b0y2	315	23	Anti	anti	JJ
cord-261566-fn08b0y2	315	24	-	-	JJ
cord-261566-fn08b0y2	315	25	spike	spike	JJ
cord-261566-fn08b0y2	315	26	IgG	igg	NN
cord-261566-fn08b0y2	315	27	causes	cause	VBZ
cord-261566-fn08b0y2	315	28	severe	severe	JJ
cord-261566-fn08b0y2	315	29	acute	acute	JJ
cord-261566-fn08b0y2	315	30	lung	lung	NN
cord-261566-fn08b0y2	315	31	injury	injury	NN
cord-261566-fn08b0y2	315	32	by	by	IN
cord-261566-fn08b0y2	315	33	skewing	skew	VBG
cord-261566-fn08b0y2	315	34	macrophage	macrophage	NN
cord-261566-fn08b0y2	315	35	responses	response	NNS
cord-261566-fn08b0y2	315	36	during	during	IN
cord-261566-fn08b0y2	315	37	acute	acute	JJ
cord-261566-fn08b0y2	315	38	SARS	SARS	NNP
cord-261566-fn08b0y2	315	39	-	-	HYPH
cord-261566-fn08b0y2	315	40	CoV	CoV	NNP
cord-261566-fn08b0y2	315	41	infection	infection	NN
cord-261566-fn08b0y2	315	42	Clinical	clinical	JJ
cord-261566-fn08b0y2	315	43	progression	progression	NN
cord-261566-fn08b0y2	315	44	and	and	CC
cord-261566-fn08b0y2	315	45	viral	viral	JJ
cord-261566-fn08b0y2	315	46	load	load	NN
cord-261566-fn08b0y2	315	47	in	in	IN
cord-261566-fn08b0y2	315	48	a	a	DT
cord-261566-fn08b0y2	315	49	community	community	NN
cord-261566-fn08b0y2	315	50	outbreak	outbreak	NN
cord-261566-fn08b0y2	315	51	of	of	IN
cord-261566-fn08b0y2	315	52	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	315	53	-	-	HYPH
cord-261566-fn08b0y2	315	54	associated	associate	VBN
cord-261566-fn08b0y2	315	55	SARS	SARS	NNP
cord-261566-fn08b0y2	315	56	pneumonia	pneumonia	NN
cord-261566-fn08b0y2	315	57	:	:	:
cord-261566-fn08b0y2	315	58	a	a	DT
cord-261566-fn08b0y2	315	59	prospective	prospective	JJ
cord-261566-fn08b0y2	315	60	study	study	NN
cord-261566-fn08b0y2	315	61	Understanding	Understanding	NNP
cord-261566-fn08b0y2	315	62	SARS	SARS	NNP
cord-261566-fn08b0y2	315	63	-	-	HYPH
cord-261566-fn08b0y2	315	64	CoV-2-mediated	cov-2-mediate	VBN
cord-261566-fn08b0y2	315	65	inflammatory	inflammatory	JJ
cord-261566-fn08b0y2	315	66	responses	response	NNS
cord-261566-fn08b0y2	315	67	:	:	:
cord-261566-fn08b0y2	315	68	from	from	IN
cord-261566-fn08b0y2	315	69	mechanisms	mechanism	NNS
cord-261566-fn08b0y2	315	70	to	to	IN
cord-261566-fn08b0y2	315	71	potential	potential	JJ
cord-261566-fn08b0y2	315	72	therapeutic	therapeutic	JJ
cord-261566-fn08b0y2	315	73	tools	tool	NNS
cord-261566-fn08b0y2	315	74	.	.	.
cord-261566-fn08b0y2	316	1	Virol	Virol	NNP
cord-261566-fn08b0y2	316	2	Sin	sin	NN
cord-261566-fn08b0y2	316	3	.	.	.
cord-261566-fn08b0y2	317	1	2020	2020	CD
cord-261566-fn08b0y2	318	1	Receptorbinding	receptorbinding	NN
cord-261566-fn08b0y2	318	2	domain	domain	NN
cord-261566-fn08b0y2	318	3	of	of	IN
cord-261566-fn08b0y2	318	4	SARS	SARS	NNP
cord-261566-fn08b0y2	318	5	-	-	HYPH
cord-261566-fn08b0y2	318	6	CoV	CoV	NNP
cord-261566-fn08b0y2	318	7	spike	spike	NN
cord-261566-fn08b0y2	318	8	protein	protein	NN
cord-261566-fn08b0y2	318	9	induces	induce	VBZ
cord-261566-fn08b0y2	318	10	highly	highly	RB
cord-261566-fn08b0y2	318	11	potent	potent	JJ
cord-261566-fn08b0y2	318	12	neutralizing	neutralize	VBG
cord-261566-fn08b0y2	318	13	antibodies	antibody	NNS
cord-261566-fn08b0y2	318	14	:	:	:
cord-261566-fn08b0y2	318	15	implication	implication	NN
cord-261566-fn08b0y2	318	16	for	for	IN
cord-261566-fn08b0y2	318	17	developing	develop	VBG
cord-261566-fn08b0y2	318	18	subunit	subunit	JJ
cord-261566-fn08b0y2	318	19	vaccine	vaccine	NN
cord-261566-fn08b0y2	318	20	Receptor	receptor	NN
cord-261566-fn08b0y2	318	21	-	-	HYPH
cord-261566-fn08b0y2	318	22	binding	bind	VBG
cord-261566-fn08b0y2	318	23	domains	domain	NNS
cord-261566-fn08b0y2	318	24	of	of	IN
cord-261566-fn08b0y2	318	25	spike	spike	NN
cord-261566-fn08b0y2	318	26	proteins	protein	NNS
cord-261566-fn08b0y2	318	27	of	of	IN
cord-261566-fn08b0y2	318	28	emerging	emerge	VBG
cord-261566-fn08b0y2	318	29	or	or	CC
cord-261566-fn08b0y2	318	30	re	re	VB
cord-261566-fn08b0y2	318	31	-	-	JJ
cord-261566-fn08b0y2	318	32	emerging	emerge	VBG
cord-261566-fn08b0y2	318	33	viruses	virus	NNS
cord-261566-fn08b0y2	318	34	as	as	IN
cord-261566-fn08b0y2	318	35	targets	target	NNS
cord-261566-fn08b0y2	318	36	for	for	IN
cord-261566-fn08b0y2	318	37	development	development	NN
cord-261566-fn08b0y2	318	38	of	of	IN
cord-261566-fn08b0y2	318	39	antiviral	antiviral	JJ
cord-261566-fn08b0y2	318	40	vaccines	vaccine	NNS
cord-261566-fn08b0y2	318	41	Structure	Structure	NNP
cord-261566-fn08b0y2	318	42	of	of	IN
cord-261566-fn08b0y2	318	43	the	the	DT
cord-261566-fn08b0y2	318	44	SARS	SARS	NNP
cord-261566-fn08b0y2	318	45	-	-	HYPH
cord-261566-fn08b0y2	318	46	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	318	47	spike	spike	NN
cord-261566-fn08b0y2	318	48	receptor	receptor	NN
cord-261566-fn08b0y2	318	49	-	-	HYPH
cord-261566-fn08b0y2	318	50	binding	bind	VBG
cord-261566-fn08b0y2	318	51	domain	domain	NN
cord-261566-fn08b0y2	318	52	bound	bind	VBN
cord-261566-fn08b0y2	318	53	to	to	IN
cord-261566-fn08b0y2	318	54	the	the	DT
cord-261566-fn08b0y2	318	55	ACE2	ACE2	NNP
cord-261566-fn08b0y2	318	56	receptor	receptor	NN
cord-261566-fn08b0y2	318	57	Immunogenicity	Immunogenicity	NNP
cord-261566-fn08b0y2	318	58	and	and	CC
cord-261566-fn08b0y2	318	59	protection	protection	NN
cord-261566-fn08b0y2	318	60	efficacy	efficacy	NN
cord-261566-fn08b0y2	318	61	of	of	IN
cord-261566-fn08b0y2	318	62	monomeric	monomeric	JJ
cord-261566-fn08b0y2	318	63	and	and	CC
cord-261566-fn08b0y2	318	64	trimeric	trimeric	JJ
cord-261566-fn08b0y2	318	65	recombinant	recombinant	JJ
cord-261566-fn08b0y2	318	66	SARS	SARS	NNP
cord-261566-fn08b0y2	318	67	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	318	68	spike	spike	NN
cord-261566-fn08b0y2	318	69	protein	protein	NN
cord-261566-fn08b0y2	318	70	subunit	subunit	NN
cord-261566-fn08b0y2	318	71	vaccine	vaccine	NN
cord-261566-fn08b0y2	318	72	candidates	candidate	NNS
cord-261566-fn08b0y2	318	73	Elicitation	Elicitation	NNP
cord-261566-fn08b0y2	318	74	of	of	IN
cord-261566-fn08b0y2	318	75	immunity	immunity	NN
cord-261566-fn08b0y2	318	76	in	in	IN
cord-261566-fn08b0y2	318	77	mice	mouse	NNS
cord-261566-fn08b0y2	318	78	after	after	IN
cord-261566-fn08b0y2	318	79	immunization	immunization	NN
cord-261566-fn08b0y2	318	80	with	with	IN
cord-261566-fn08b0y2	318	81	the	the	DT
cord-261566-fn08b0y2	318	82	S2	S2	NNP
cord-261566-fn08b0y2	318	83	subunit	subunit	NN
cord-261566-fn08b0y2	318	84	of	of	IN
cord-261566-fn08b0y2	318	85	the	the	DT
cord-261566-fn08b0y2	318	86	severe	severe	JJ
cord-261566-fn08b0y2	318	87	acute	acute	JJ
cord-261566-fn08b0y2	318	88	respiratory	respiratory	JJ
cord-261566-fn08b0y2	318	89	syndrome	syndrome	NN
cord-261566-fn08b0y2	318	90	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	319	1	The	the	DT
cord-261566-fn08b0y2	319	2	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	319	3	nucleocapsid	nucleocapsid	NN
cord-261566-fn08b0y2	319	4	is	be	VBZ
cord-261566-fn08b0y2	319	5	a	a	DT
cord-261566-fn08b0y2	319	6	multifunctional	multifunctional	JJ
cord-261566-fn08b0y2	319	7	protein	protein	NN
cord-261566-fn08b0y2	319	8	Structural	Structural	NNP
cord-261566-fn08b0y2	319	9	Genomics	Genomics	NNPS
cord-261566-fn08b0y2	319	10	of	of	IN
cord-261566-fn08b0y2	319	11	SARS	SARS	NNP
cord-261566-fn08b0y2	319	12	-	-	HYPH
cord-261566-fn08b0y2	319	13	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	319	14	indicates	indicate	VBZ
cord-261566-fn08b0y2	319	15	evolutionary	evolutionary	JJ
cord-261566-fn08b0y2	319	16	conserved	conserve	VBN
cord-261566-fn08b0y2	319	17	functional	functional	JJ
cord-261566-fn08b0y2	319	18	regions	region	NNS
cord-261566-fn08b0y2	319	19	of	of	IN
cord-261566-fn08b0y2	319	20	viral	viral	JJ
cord-261566-fn08b0y2	319	21	proteins	protein	NNS
cord-261566-fn08b0y2	320	1	A	a	DT
cord-261566-fn08b0y2	320	2	Universal	Universal	NNP
cord-261566-fn08b0y2	320	3	Influenza	Influenza	NNP
cord-261566-fn08b0y2	320	4	Vaccine	vaccine	NN
cord-261566-fn08b0y2	320	5	:	:	:
cord-261566-fn08b0y2	321	1	the	the	DT
cord-261566-fn08b0y2	321	2	Strategic	Strategic	NNP
cord-261566-fn08b0y2	321	3	Plan	Plan	NNP
cord-261566-fn08b0y2	321	4	for	for	IN
cord-261566-fn08b0y2	321	5	the	the	DT
cord-261566-fn08b0y2	321	6	National	National	NNP
cord-261566-fn08b0y2	321	7	Institute	Institute	NNP
cord-261566-fn08b0y2	321	8	of	of	IN
cord-261566-fn08b0y2	321	9	Allergy	Allergy	NNP
cord-261566-fn08b0y2	321	10	and	and	CC
cord-261566-fn08b0y2	321	11	Infectious	Infectious	NNP
cord-261566-fn08b0y2	321	12	Diseases	Diseases	NNPS
cord-261566-fn08b0y2	321	13	Novel	Novel	NNP
cord-261566-fn08b0y2	321	14	antibody	antibody	NN
cord-261566-fn08b0y2	321	15	epitopes	epitope	NNS
cord-261566-fn08b0y2	321	16	dominate	dominate	VBP
cord-261566-fn08b0y2	321	17	the	the	DT
cord-261566-fn08b0y2	321	18	antigenicity	antigenicity	NN
cord-261566-fn08b0y2	321	19	of	of	IN
cord-261566-fn08b0y2	321	20	spike	spike	NN
cord-261566-fn08b0y2	321	21	glycoprotein	glycoprotein	NN
cord-261566-fn08b0y2	321	22	in	in	IN
cord-261566-fn08b0y2	321	23	SARS	SARS	NNP
cord-261566-fn08b0y2	321	24	-	-	HYPH
cord-261566-fn08b0y2	321	25	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	321	26	compared	compare	VBN
cord-261566-fn08b0y2	321	27	to	to	IN
cord-261566-fn08b0y2	321	28	SARS	SARS	NNP
cord-261566-fn08b0y2	321	29	-	-	HYPH
cord-261566-fn08b0y2	321	30	CoV	CoV	NNP
cord-261566-fn08b0y2	321	31	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	321	32	vaccines	vaccine	NNS
cord-261566-fn08b0y2	321	33	:	:	:
cord-261566-fn08b0y2	321	34	the	the	DT
cord-261566-fn08b0y2	321	35	promise	promise	NN
cord-261566-fn08b0y2	321	36	and	and	CC
cord-261566-fn08b0y2	321	37	the	the	DT
cord-261566-fn08b0y2	321	38	challenge	challenge	NN
cord-261566-fn08b0y2	321	39	Vaccine	Vaccine	NNP
cord-261566-fn08b0y2	321	40	delivery	delivery	NN
cord-261566-fn08b0y2	321	41	:	:	:
cord-261566-fn08b0y2	321	42	a	a	DT
cord-261566-fn08b0y2	321	43	matter	matter	NN
cord-261566-fn08b0y2	321	44	of	of	IN
cord-261566-fn08b0y2	321	45	size	size	NN
cord-261566-fn08b0y2	321	46	,	,	,
cord-261566-fn08b0y2	321	47	geometry	geometry	NN
cord-261566-fn08b0y2	321	48	,	,	,
cord-261566-fn08b0y2	321	49	kinetics	kinetics	NN
cord-261566-fn08b0y2	321	50	and	and	CC
cord-261566-fn08b0y2	321	51	molecular	molecular	JJ
cord-261566-fn08b0y2	321	52	patterns	pattern	NNS
cord-261566-fn08b0y2	321	53	2020	2020	CD
cord-261566-fn08b0y2	321	54	vision	vision	NN
cord-261566-fn08b0y2	321	55	for	for	IN
cord-261566-fn08b0y2	321	56	vaccines	vaccine	NNS
cord-261566-fn08b0y2	321	57	against	against	IN
cord-261566-fn08b0y2	321	58	HIV	HIV	NNP
cord-261566-fn08b0y2	321	59	,	,	,
cord-261566-fn08b0y2	321	60	tuberculosis	tuberculosis	NN
cord-261566-fn08b0y2	321	61	and	and	CC
cord-261566-fn08b0y2	321	62	malaria	malaria	NN
cord-261566-fn08b0y2	322	1	The	the	DT
cord-261566-fn08b0y2	322	2	development	development	NN
cord-261566-fn08b0y2	322	3	of	of	IN
cord-261566-fn08b0y2	322	4	mucosal	mucosal	JJ
cord-261566-fn08b0y2	322	5	vaccines	vaccine	NNS
cord-261566-fn08b0y2	322	6	for	for	IN
cord-261566-fn08b0y2	322	7	both	both	DT
cord-261566-fn08b0y2	322	8	mucosal	mucosal	JJ
cord-261566-fn08b0y2	322	9	and	and	CC
cord-261566-fn08b0y2	322	10	systemic	systemic	JJ
cord-261566-fn08b0y2	322	11	immune	immune	JJ
cord-261566-fn08b0y2	322	12	induction	induction	NN
cord-261566-fn08b0y2	322	13	and	and	CC
cord-261566-fn08b0y2	322	14	the	the	DT
cord-261566-fn08b0y2	322	15	roles	role	NNS
cord-261566-fn08b0y2	322	16	played	play	VBN
cord-261566-fn08b0y2	322	17	by	by	IN
cord-261566-fn08b0y2	322	18	adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	323	1	Enhanced	enhanced	JJ
cord-261566-fn08b0y2	323	2	mucosal	mucosal	JJ
cord-261566-fn08b0y2	323	3	and	and	CC
cord-261566-fn08b0y2	323	4	systemic	systemic	JJ
cord-261566-fn08b0y2	323	5	immune	immune	JJ
cord-261566-fn08b0y2	323	6	response	response	NN
cord-261566-fn08b0y2	323	7	with	with	IN
cord-261566-fn08b0y2	323	8	intranasal	intranasal	NN
cord-261566-fn08b0y2	323	9	immunization	immunization	NN
cord-261566-fn08b0y2	323	10	of	of	IN
cord-261566-fn08b0y2	323	11	mice	mouse	NNS
cord-261566-fn08b0y2	323	12	with	with	IN
cord-261566-fn08b0y2	323	13	HIV	HIV	NNP
cord-261566-fn08b0y2	323	14	peptides	peptide	NNS
cord-261566-fn08b0y2	323	15	entrapped	entrap	VBN
cord-261566-fn08b0y2	323	16	in	in	IN
cord-261566-fn08b0y2	323	17	PLG	PLG	NNP
cord-261566-fn08b0y2	323	18	microparticles	microparticle	NNS
cord-261566-fn08b0y2	323	19	in	in	IN
cord-261566-fn08b0y2	323	20	combination	combination	NN
cord-261566-fn08b0y2	323	21	with	with	IN
cord-261566-fn08b0y2	323	22	Ulex	Ulex	NNP
cord-261566-fn08b0y2	323	23	Europaeus	Europaeus	NNP
cord-261566-fn08b0y2	323	24	-	-	HYPH
cord-261566-fn08b0y2	323	25	I	-PRON-	PRP
cord-261566-fn08b0y2	323	26	lectin	lectin	NN
cord-261566-fn08b0y2	323	27	as	as	IN
cord-261566-fn08b0y2	323	28	M	M	NNP
cord-261566-fn08b0y2	323	29	cell	cell	NN
cord-261566-fn08b0y2	323	30	target	target	NN
cord-261566-fn08b0y2	323	31	The	the	DT
cord-261566-fn08b0y2	323	32	basics	basic	NNS
cord-261566-fn08b0y2	323	33	and	and	CC
cord-261566-fn08b0y2	323	34	underlying	underlie	VBG
cord-261566-fn08b0y2	323	35	mechanisms	mechanism	NNS
cord-261566-fn08b0y2	323	36	of	of	IN
cord-261566-fn08b0y2	323	37	mucoadhesion	mucoadhesion	NN
cord-261566-fn08b0y2	323	38	Differential	differential	JJ
cord-261566-fn08b0y2	323	39	expression	expression	NN
cord-261566-fn08b0y2	323	40	of	of	IN
cord-261566-fn08b0y2	323	41	lectin	lectin	NN
cord-261566-fn08b0y2	323	42	-	-	HYPH
cord-261566-fn08b0y2	323	43	binding	bind	VBG
cord-261566-fn08b0y2	323	44	sites	site	NNS
cord-261566-fn08b0y2	323	45	defines	define	VBZ
cord-261566-fn08b0y2	323	46	mouse	mouse	NN
cord-261566-fn08b0y2	323	47	intestinal	intestinal	JJ
cord-261566-fn08b0y2	323	48	M	M	NNP
cord-261566-fn08b0y2	323	49	-	-	HYPH
cord-261566-fn08b0y2	323	50	cells	cell	NNS
cord-261566-fn08b0y2	323	51	Pre	pre	JJ
cord-261566-fn08b0y2	323	52	-	-	JJ
cord-261566-fn08b0y2	323	53	clinical	clinical	JJ
cord-261566-fn08b0y2	323	54	evaluation	evaluation	NN
cord-261566-fn08b0y2	323	55	of	of	IN
cord-261566-fn08b0y2	323	56	a	a	DT
cord-261566-fn08b0y2	323	57	novel	novel	JJ
cord-261566-fn08b0y2	323	58	nanoemulsion	nanoemulsion	NN
cord-261566-fn08b0y2	323	59	-	-	HYPH
cord-261566-fn08b0y2	323	60	based	base	VBN
cord-261566-fn08b0y2	323	61	hepatitis	hepatitis	NN
cord-261566-fn08b0y2	323	62	B	B	NNP
cord-261566-fn08b0y2	323	63	mucosal	mucosal	JJ
cord-261566-fn08b0y2	323	64	vaccine	vaccine	NN
cord-261566-fn08b0y2	323	65	Vaccine	vaccine	NN
cord-261566-fn08b0y2	323	66	adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	323	67	:	:	:
cord-261566-fn08b0y2	323	68	putting	put	VBG
cord-261566-fn08b0y2	323	69	innate	innate	JJ
cord-261566-fn08b0y2	323	70	immunity	immunity	NN
cord-261566-fn08b0y2	323	71	to	to	TO
cord-261566-fn08b0y2	323	72	work	work	VB
cord-261566-fn08b0y2	323	73	CpG	CpG	NNP
cord-261566-fn08b0y2	323	74	DNA	DNA	NNP
cord-261566-fn08b0y2	323	75	as	as	IN
cord-261566-fn08b0y2	323	76	a	a	DT
cord-261566-fn08b0y2	323	77	vaccine	vaccine	NN
cord-261566-fn08b0y2	323	78	adjuvant	adjuvant	JJ
cord-261566-fn08b0y2	323	79	Heat	heat	NN
cord-261566-fn08b0y2	323	80	-	-	HYPH
cord-261566-fn08b0y2	323	81	labile	labile	JJ
cord-261566-fn08b0y2	323	82	enterotoxins	enterotoxin	NNS
cord-261566-fn08b0y2	323	83	as	as	IN
cord-261566-fn08b0y2	323	84	adjuvants	adjuvant	NNS
cord-261566-fn08b0y2	323	85	or	or	CC
cord-261566-fn08b0y2	323	86	anti	anti	JJ
cord-261566-fn08b0y2	323	87	-	-	JJ
cord-261566-fn08b0y2	323	88	inflammatory	inflammatory	JJ
cord-261566-fn08b0y2	323	89	agents	agent	NNS
cord-261566-fn08b0y2	323	90	Dendritic	dendritic	JJ
cord-261566-fn08b0y2	323	91	cells	cell	NNS
cord-261566-fn08b0y2	323	92	and	and	CC
cord-261566-fn08b0y2	323	93	immune	immune	JJ
cord-261566-fn08b0y2	323	94	responses	response	NNS
cord-261566-fn08b0y2	323	95	to	to	IN
cord-261566-fn08b0y2	323	96	orally	orally	RB
cord-261566-fn08b0y2	323	97	administered	administer	VBN
cord-261566-fn08b0y2	323	98	antigens	antigen	NNS
cord-261566-fn08b0y2	323	99	Oral	oral	JJ
cord-261566-fn08b0y2	323	100	tolerance	tolerance	NN
cord-261566-fn08b0y2	323	101	:	:	:
cord-261566-fn08b0y2	323	102	immunologic	immunologic	JJ
cord-261566-fn08b0y2	323	103	mechanisms	mechanism	NNS
cord-261566-fn08b0y2	323	104	and	and	CC
cord-261566-fn08b0y2	323	105	treatment	treatment	NN
cord-261566-fn08b0y2	323	106	of	of	IN
cord-261566-fn08b0y2	323	107	animal	animal	NN
cord-261566-fn08b0y2	323	108	and	and	CC
cord-261566-fn08b0y2	323	109	human	human	JJ
cord-261566-fn08b0y2	323	110	organ	organ	NN
cord-261566-fn08b0y2	323	111	-	-	HYPH
cord-261566-fn08b0y2	323	112	specific	specific	JJ
cord-261566-fn08b0y2	323	113	autoimmune	autoimmune	JJ
cord-261566-fn08b0y2	323	114	diseases	disease	NNS
cord-261566-fn08b0y2	323	115	by	by	IN
cord-261566-fn08b0y2	323	116	oral	oral	JJ
cord-261566-fn08b0y2	323	117	administration	administration	NNP
cord-261566-fn08b0y2	323	118	of	of	IN
cord-261566-fn08b0y2	323	119	autoantigens	autoantigens	NNP
cord-261566-fn08b0y2	324	1	In	in	IN
cord-261566-fn08b0y2	324	2	vivo	vivo	NN
cord-261566-fn08b0y2	324	3	targeting	target	VBG
cord-261566-fn08b0y2	324	4	of	of	IN
cord-261566-fn08b0y2	324	5	antigens	antigen	NNS
cord-261566-fn08b0y2	324	6	to	to	IN
cord-261566-fn08b0y2	324	7	maturing	mature	VBG
cord-261566-fn08b0y2	324	8	dendritic	dendritic	JJ
cord-261566-fn08b0y2	324	9	cells	cell	NNS
cord-261566-fn08b0y2	324	10	via	via	IN
cord-261566-fn08b0y2	324	11	the	the	DT
cord-261566-fn08b0y2	324	12	DEC-205	DEC-205	NNP
cord-261566-fn08b0y2	324	13	receptor	receptor	NN
cord-261566-fn08b0y2	324	14	improves	improve	VBZ
cord-261566-fn08b0y2	324	15	T	T	NNP
cord-261566-fn08b0y2	324	16	cell	cell	NN
cord-261566-fn08b0y2	324	17	vaccination	vaccination	NN
cord-261566-fn08b0y2	324	18	Triggering	trigger	VBG
cord-261566-fn08b0y2	324	19	TLR	TLR	NNP
cord-261566-fn08b0y2	324	20	signaling	signal	VBG
cord-261566-fn08b0y2	324	21	in	in	IN
cord-261566-fn08b0y2	324	22	vaccination	vaccination	NN
cord-261566-fn08b0y2	324	23	The	the	DT
cord-261566-fn08b0y2	324	24	time	time	NN
cord-261566-fn08b0y2	324	25	course	course	NN
cord-261566-fn08b0y2	324	26	of	of	IN
cord-261566-fn08b0y2	324	27	the	the	DT
cord-261566-fn08b0y2	324	28	immune	immune	JJ
cord-261566-fn08b0y2	324	29	response	response	NN
cord-261566-fn08b0y2	324	30	to	to	IN
cord-261566-fn08b0y2	324	31	experimental	experimental	JJ
cord-261566-fn08b0y2	324	32	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	324	33	infection	infection	NN
cord-261566-fn08b0y2	324	34	of	of	IN
cord-261566-fn08b0y2	324	35	man	man	NN
cord-261566-fn08b0y2	324	36	Two	two	CD
cord-261566-fn08b0y2	324	37	-	-	HYPH
cord-261566-fn08b0y2	324	38	year	year	NN
cord-261566-fn08b0y2	324	39	prospective	prospective	JJ
cord-261566-fn08b0y2	324	40	study	study	NN
cord-261566-fn08b0y2	324	41	of	of	IN
cord-261566-fn08b0y2	324	42	the	the	DT
cord-261566-fn08b0y2	324	43	humoral	humoral	JJ
cord-261566-fn08b0y2	324	44	immune	immune	JJ
cord-261566-fn08b0y2	324	45	response	response	NN
cord-261566-fn08b0y2	324	46	of	of	IN
cord-261566-fn08b0y2	324	47	patients	patient	NNS
cord-261566-fn08b0y2	324	48	with	with	IN
cord-261566-fn08b0y2	324	49	severe	severe	JJ
cord-261566-fn08b0y2	324	50	acute	acute	JJ
cord-261566-fn08b0y2	324	51	respiratory	respiratory	JJ
cord-261566-fn08b0y2	324	52	syndrome	syndrome	NN
cord-261566-fn08b0y2	324	53	Duration	duration	NN
cord-261566-fn08b0y2	324	54	of	of	IN
cord-261566-fn08b0y2	324	55	antibody	antibody	NN
cord-261566-fn08b0y2	324	56	responses	response	NNS
cord-261566-fn08b0y2	324	57	after	after	IN
cord-261566-fn08b0y2	324	58	severe	severe	JJ
cord-261566-fn08b0y2	324	59	acute	acute	JJ
cord-261566-fn08b0y2	324	60	respiratory	respiratory	JJ
cord-261566-fn08b0y2	324	61	syndrome	syndrome	NN
cord-261566-fn08b0y2	324	62	Evaluation	evaluation	NN
cord-261566-fn08b0y2	324	63	of	of	IN
cord-261566-fn08b0y2	324	64	events	event	NNS
cord-261566-fn08b0y2	324	65	occurring	occur	VBG
cord-261566-fn08b0y2	324	66	at	at	IN
cord-261566-fn08b0y2	324	67	mucosal	mucosal	JJ
cord-261566-fn08b0y2	324	68	surfaces	surface	NNS
cord-261566-fn08b0y2	324	69	:	:	:
cord-261566-fn08b0y2	324	70	techniques	technique	NNS
cord-261566-fn08b0y2	324	71	used	use	VBN
cord-261566-fn08b0y2	324	72	to	to	TO
cord-261566-fn08b0y2	324	73	collect	collect	VB
cord-261566-fn08b0y2	324	74	and	and	CC
cord-261566-fn08b0y2	324	75	analyze	analyze	VB
cord-261566-fn08b0y2	324	76	mucosal	mucosal	JJ
cord-261566-fn08b0y2	324	77	secretions	secretion	NNS
cord-261566-fn08b0y2	324	78	and	and	CC
cord-261566-fn08b0y2	324	79	cells	cell	NNS
cord-261566-fn08b0y2	324	80	Correlates	correlate	NNS
cord-261566-fn08b0y2	324	81	of	of	IN
cord-261566-fn08b0y2	324	82	protection	protection	NN
cord-261566-fn08b0y2	324	83	induced	induce	VBN
cord-261566-fn08b0y2	324	84	by	by	IN
cord-261566-fn08b0y2	324	85	vaccination	vaccination	NN
cord-261566-fn08b0y2	324	86	Systems	Systems	NNP
cord-261566-fn08b0y2	324	87	biological	biological	JJ
cord-261566-fn08b0y2	324	88	approaches	approach	NNS
cord-261566-fn08b0y2	324	89	for	for	IN
cord-261566-fn08b0y2	324	90	mucosal	mucosal	JJ
cord-261566-fn08b0y2	324	91	vaccine	vaccine	NN
cord-261566-fn08b0y2	324	92	development	development	NN
cord-261566-fn08b0y2	324	93	Middle	Middle	NNP
cord-261566-fn08b0y2	324	94	East	East	NNP
cord-261566-fn08b0y2	324	95	respiratory	respiratory	JJ
cord-261566-fn08b0y2	324	96	syndrome	syndrome	NN
cord-261566-fn08b0y2	324	97	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	324	98	(	(	-LRB-
cord-261566-fn08b0y2	324	99	MERS	MERS	NNP
cord-261566-fn08b0y2	324	100	-	-	HYPH
cord-261566-fn08b0y2	324	101	CoV	CoV	NNP
cord-261566-fn08b0y2	324	102	)	)	-RRB-
cord-261566-fn08b0y2	324	103	causes	cause	VBZ
cord-261566-fn08b0y2	324	104	transient	transient	JJ
cord-261566-fn08b0y2	324	105	lower	low	JJR
cord-261566-fn08b0y2	324	106	respiratory	respiratory	JJ
cord-261566-fn08b0y2	324	107	tract	tract	NN
cord-261566-fn08b0y2	324	108	infection	infection	NN
cord-261566-fn08b0y2	324	109	in	in	IN
cord-261566-fn08b0y2	324	110	rhesus	rhesus	NN
cord-261566-fn08b0y2	324	111	macaques	macaque	NNS
cord-261566-fn08b0y2	324	112	Pneumonia	Pneumonia	NNP
cord-261566-fn08b0y2	324	113	from	from	IN
cord-261566-fn08b0y2	324	114	human	human	JJ
cord-261566-fn08b0y2	324	115	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	324	116	in	in	IN
cord-261566-fn08b0y2	324	117	a	a	DT
cord-261566-fn08b0y2	324	118	macaque	macaque	NN
cord-261566-fn08b0y2	324	119	model	model	NN
cord-261566-fn08b0y2	325	1	SARS	SARS	NNP
cord-261566-fn08b0y2	325	2	virus	virus	NN
cord-261566-fn08b0y2	325	3	infection	infection	NN
cord-261566-fn08b0y2	325	4	of	of	IN
cord-261566-fn08b0y2	325	5	cats	cat	NNS
cord-261566-fn08b0y2	325	6	and	and	CC
cord-261566-fn08b0y2	325	7	ferrets	ferret	NNS
cord-261566-fn08b0y2	325	8	Prior	prior	CC
cord-261566-fn08b0y2	325	9	Infection	infection	NN
cord-261566-fn08b0y2	325	10	and	and	CC
cord-261566-fn08b0y2	325	11	passive	passive	JJ
cord-261566-fn08b0y2	325	12	transfer	transfer	NN
cord-261566-fn08b0y2	325	13	of	of	IN
cord-261566-fn08b0y2	325	14	neutralizing	neutralize	VBG
cord-261566-fn08b0y2	325	15	antibody	antibody	NN
cord-261566-fn08b0y2	325	16	prevent	prevent	VB
cord-261566-fn08b0y2	325	17	replication	replication	NN
cord-261566-fn08b0y2	325	18	of	of	IN
cord-261566-fn08b0y2	325	19	severe	severe	JJ
cord-261566-fn08b0y2	325	20	acute	acute	JJ
cord-261566-fn08b0y2	325	21	respiratory	respiratory	JJ
cord-261566-fn08b0y2	325	22	syndrome	syndrome	NN
cord-261566-fn08b0y2	325	23	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	325	24	in	in	IN
cord-261566-fn08b0y2	325	25	the	the	DT
cord-261566-fn08b0y2	325	26	respiratory	respiratory	JJ
cord-261566-fn08b0y2	325	27	tract	tract	NN
cord-261566-fn08b0y2	325	28	of	of	IN
cord-261566-fn08b0y2	325	29	mice	mouse	NNS
cord-261566-fn08b0y2	325	30	Severe	severe	JJ
cord-261566-fn08b0y2	325	31	Acute	acute	JJ
cord-261566-fn08b0y2	325	32	Respiratory	respiratory	JJ
cord-261566-fn08b0y2	325	33	Syndrome	Syndrome	NNP
cord-261566-fn08b0y2	325	34	Coronavirus	Coronavirus	NNP
cord-261566-fn08b0y2	325	35	Infection	infection	NN
cord-261566-fn08b0y2	325	36	of	of	IN
cord-261566-fn08b0y2	325	37	Golden	golden	JJ
cord-261566-fn08b0y2	325	38	Syrian	syrian	JJ
cord-261566-fn08b0y2	325	39	Hamsters	hamster	NNS
cord-261566-fn08b0y2	326	1	Severe	severe	JJ
cord-261566-fn08b0y2	326	2	acute	acute	JJ
cord-261566-fn08b0y2	326	3	respiratory	respiratory	JJ
cord-261566-fn08b0y2	326	4	syndrome	syndrome	NN
cord-261566-fn08b0y2	326	5	vaccine	vaccine	NN
cord-261566-fn08b0y2	326	6	efficacy	efficacy	NN
cord-261566-fn08b0y2	326	7	in	in	IN
cord-261566-fn08b0y2	326	8	ferrets	ferret	NNS
cord-261566-fn08b0y2	326	9	:	:	:
cord-261566-fn08b0y2	327	1	whole	whole	RB
cord-261566-fn08b0y2	327	2	killed	kill	VBN
cord-261566-fn08b0y2	327	3	virus	virus	NN
cord-261566-fn08b0y2	327	4	and	and	CC
cord-261566-fn08b0y2	327	5	adenovirus	adenovirus	NN
cord-261566-fn08b0y2	327	6	-	-	HYPH
cord-261566-fn08b0y2	327	7	vectored	vectore	VBN
cord-261566-fn08b0y2	327	8	vaccines	vaccine	NNS
cord-261566-fn08b0y2	327	9	Adenovirus	Adenovirus	NNP
cord-261566-fn08b0y2	327	10	-	-	HYPH
cord-261566-fn08b0y2	327	11	based	base	VBN
cord-261566-fn08b0y2	327	12	vaccine	vaccine	NN
cord-261566-fn08b0y2	327	13	prevents	prevent	VBZ
cord-261566-fn08b0y2	327	14	pneumonia	pneumonia	NN
cord-261566-fn08b0y2	327	15	in	in	IN
cord-261566-fn08b0y2	327	16	ferrets	ferret	NNS
cord-261566-fn08b0y2	327	17	challenged	challenge	VBN
cord-261566-fn08b0y2	327	18	with	with	IN
cord-261566-fn08b0y2	327	19	the	the	DT
cord-261566-fn08b0y2	327	20	SARS	SARS	NNP
cord-261566-fn08b0y2	327	21	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	327	22	and	and	CC
cord-261566-fn08b0y2	327	23	stimulates	stimulate	VBZ
cord-261566-fn08b0y2	327	24	robust	robust	JJ
cord-261566-fn08b0y2	327	25	immune	immune	JJ
cord-261566-fn08b0y2	327	26	responses	response	NNS
cord-261566-fn08b0y2	327	27	in	in	IN
cord-261566-fn08b0y2	327	28	macaques	macaque	NNS
cord-261566-fn08b0y2	328	1	The	the	DT
cord-261566-fn08b0y2	328	2	Pathogenicity	Pathogenicity	NNP
cord-261566-fn08b0y2	328	3	of	of	IN
cord-261566-fn08b0y2	328	4	SARS	SARS	NNP
cord-261566-fn08b0y2	328	5	-	-	HYPH
cord-261566-fn08b0y2	328	6	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	328	7	in	in	IN
cord-261566-fn08b0y2	328	8	hACE2	hace2	ADD
cord-261566-fn08b0y2	329	1	Transgenic	transgenic	JJ
cord-261566-fn08b0y2	329	2	Mice	mouse	NNS
cord-261566-fn08b0y2	330	1	Enhanced	enhanced	JJ
cord-261566-fn08b0y2	330	2	immunogenicity	immunogenicity	NN
cord-261566-fn08b0y2	330	3	of	of	IN
cord-261566-fn08b0y2	330	4	an	an	DT
cord-261566-fn08b0y2	330	5	oral	oral	JJ
cord-261566-fn08b0y2	330	6	inactivated	inactivate	VBN
cord-261566-fn08b0y2	330	7	cholera	cholera	NN
cord-261566-fn08b0y2	330	8	vaccine	vaccine	NN
cord-261566-fn08b0y2	330	9	in	in	IN
cord-261566-fn08b0y2	330	10	infants	infant	NNS
cord-261566-fn08b0y2	330	11	in	in	IN
cord-261566-fn08b0y2	330	12	Bangladesh	Bangladesh	NNP
cord-261566-fn08b0y2	330	13	obtained	obtain	VBN
cord-261566-fn08b0y2	330	14	by	by	IN
cord-261566-fn08b0y2	330	15	zinc	zinc	NN
cord-261566-fn08b0y2	330	16	supplementation	supplementation	NN
cord-261566-fn08b0y2	330	17	and	and	CC
cord-261566-fn08b0y2	330	18	by	by	IN
cord-261566-fn08b0y2	330	19	temporary	temporary	JJ
cord-261566-fn08b0y2	330	20	withholding	withhold	VBG
cord-261566-fn08b0y2	330	21	breast	breast	NN
cord-261566-fn08b0y2	330	22	-	-	HYPH
cord-261566-fn08b0y2	330	23	feeding	feed	VBG
cord-261566-fn08b0y2	330	24	Factors	factor	NNS
cord-261566-fn08b0y2	330	25	affecting	affect	VBG
cord-261566-fn08b0y2	330	26	the	the	DT
cord-261566-fn08b0y2	330	27	immunogenicity	immunogenicity	NN
cord-261566-fn08b0y2	330	28	of	of	IN
cord-261566-fn08b0y2	330	29	oral	oral	JJ
cord-261566-fn08b0y2	330	30	poliovirus	poliovirus	NN
cord-261566-fn08b0y2	330	31	vaccine	vaccine	NN
cord-261566-fn08b0y2	330	32	in	in	IN
cord-261566-fn08b0y2	330	33	developing	develop	VBG
cord-261566-fn08b0y2	330	34	countries	country	NNS
cord-261566-fn08b0y2	330	35	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	330	36	immunization	immunization	NN
cord-261566-fn08b0y2	331	1	:	:	:
cord-261566-fn08b0y2	331	2	a	a	DT
cord-261566-fn08b0y2	331	3	realistic	realistic	JJ
cord-261566-fn08b0y2	331	4	alternative	alternative	NN
cord-261566-fn08b0y2	331	5	HPV-16	HPV-16	NNP
cord-261566-fn08b0y2	331	6	L1	L1	NNP
cord-261566-fn08b0y2	331	7	VLP	VLP	NNP
cord-261566-fn08b0y2	331	8	vaccine	vaccine	NN
cord-261566-fn08b0y2	331	9	elicits	elicit	VBZ
cord-261566-fn08b0y2	331	10	a	a	DT
cord-261566-fn08b0y2	331	11	broad	broad	JJ
cord-261566-fn08b0y2	331	12	-	-	HYPH
cord-261566-fn08b0y2	331	13	spectrum	spectrum	NN
cord-261566-fn08b0y2	331	14	of	of	IN
cord-261566-fn08b0y2	331	15	cytokine	cytokine	JJ
cord-261566-fn08b0y2	331	16	responses	response	NNS
cord-261566-fn08b0y2	331	17	in	in	IN
cord-261566-fn08b0y2	331	18	whole	whole	JJ
cord-261566-fn08b0y2	331	19	blood	blood	NN
cord-261566-fn08b0y2	331	20	Evaluation	evaluation	NN
cord-261566-fn08b0y2	331	21	of	of	IN
cord-261566-fn08b0y2	331	22	the	the	DT
cord-261566-fn08b0y2	331	23	long	long	JJ
cord-261566-fn08b0y2	331	24	-	-	HYPH
cord-261566-fn08b0y2	331	25	term	term	NN
cord-261566-fn08b0y2	331	26	anti	anti	JJ
cord-261566-fn08b0y2	331	27	-	-	JJ
cord-261566-fn08b0y2	331	28	human	human	JJ
cord-261566-fn08b0y2	331	29	papillomavirus	papillomavirus	NN
cord-261566-fn08b0y2	331	30	6	6	CD
cord-261566-fn08b0y2	331	31	(	(	-LRB-
cord-261566-fn08b0y2	331	32	HPV6	HPV6	NNP
cord-261566-fn08b0y2	331	33	)	)	-RRB-
cord-261566-fn08b0y2	331	34	,	,	,
cord-261566-fn08b0y2	331	35	11	11	CD
cord-261566-fn08b0y2	331	36	,	,	,
cord-261566-fn08b0y2	331	37	16	16	CD
cord-261566-fn08b0y2	331	38	,	,	,
cord-261566-fn08b0y2	331	39	and	and	CC
cord-261566-fn08b0y2	331	40	18	18	CD
cord-261566-fn08b0y2	331	41	immune	immune	JJ
cord-261566-fn08b0y2	331	42	responses	response	NNS
cord-261566-fn08b0y2	331	43	generated	generate	VBN
cord-261566-fn08b0y2	331	44	by	by	IN
cord-261566-fn08b0y2	331	45	the	the	DT
cord-261566-fn08b0y2	331	46	quadrivalent	quadrivalent	NN
cord-261566-fn08b0y2	331	47	HPV	HPV	NNP
cord-261566-fn08b0y2	331	48	vaccine	vaccine	NN
cord-261566-fn08b0y2	331	49	Quadrivalent	Quadrivalent	NNP
cord-261566-fn08b0y2	331	50	human	human	JJ
cord-261566-fn08b0y2	331	51	papillomavirus	papillomavirus	NN
cord-261566-fn08b0y2	331	52	(	(	-LRB-
cord-261566-fn08b0y2	331	53	HPV	hpv	NN
cord-261566-fn08b0y2	331	54	)	)	-RRB-
cord-261566-fn08b0y2	331	55	vaccine	vaccine	NN
cord-261566-fn08b0y2	331	56	induces	induce	VBZ
cord-261566-fn08b0y2	331	57	HPV	hpv	NN
cord-261566-fn08b0y2	331	58	-	-	HYPH
cord-261566-fn08b0y2	331	59	specific	specific	JJ
cord-261566-fn08b0y2	331	60	antibodies	antibody	NNS
cord-261566-fn08b0y2	331	61	in	in	IN
cord-261566-fn08b0y2	331	62	the	the	DT
cord-261566-fn08b0y2	331	63	oral	oral	JJ
cord-261566-fn08b0y2	331	64	cavity	cavity	NN
cord-261566-fn08b0y2	331	65	:	:	:
cord-261566-fn08b0y2	331	66	results	result	NNS
cord-261566-fn08b0y2	331	67	from	from	IN
cord-261566-fn08b0y2	331	68	the	the	DT
cord-261566-fn08b0y2	331	69	mid	mid	JJ
cord-261566-fn08b0y2	331	70	-	-	JJ
cord-261566-fn08b0y2	331	71	adult	adult	JJ
cord-261566-fn08b0y2	331	72	male	male	JJ
cord-261566-fn08b0y2	331	73	vaccine	vaccine	NN
cord-261566-fn08b0y2	331	74	trial	trial	NN
cord-261566-fn08b0y2	331	75	Long	long	JJ
cord-261566-fn08b0y2	331	76	-	-	HYPH
cord-261566-fn08b0y2	331	77	term	term	NN
cord-261566-fn08b0y2	331	78	persistence	persistence	NN
cord-261566-fn08b0y2	331	79	of	of	IN
cord-261566-fn08b0y2	331	80	systemic	systemic	JJ
cord-261566-fn08b0y2	331	81	and	and	CC
cord-261566-fn08b0y2	331	82	mucosal	mucosal	JJ
cord-261566-fn08b0y2	331	83	immune	immune	JJ
cord-261566-fn08b0y2	331	84	response	response	NN
cord-261566-fn08b0y2	331	85	to	to	IN
cord-261566-fn08b0y2	331	86	HPV-16/18	HPV-16/18	NNP
cord-261566-fn08b0y2	331	87	AS04-adjuvanted	as04-adjuvanted	CD
cord-261566-fn08b0y2	331	88	vaccine	vaccine	NN
cord-261566-fn08b0y2	331	89	in	in	IN
cord-261566-fn08b0y2	331	90	preteen	preteen	NNP
cord-261566-fn08b0y2	331	91	/	/	SYM
cord-261566-fn08b0y2	331	92	adolescent	adolescent	JJ
cord-261566-fn08b0y2	331	93	girls	girl	NNS
cord-261566-fn08b0y2	331	94	and	and	CC
cord-261566-fn08b0y2	331	95	young	young	JJ
cord-261566-fn08b0y2	331	96	women	woman	NNS
cord-261566-fn08b0y2	331	97	Live	live	VBP
cord-261566-fn08b0y2	331	98	and	and	CC
cord-261566-fn08b0y2	332	1	inactivated	inactivate	VBN
cord-261566-fn08b0y2	332	2	influenza	influenza	NN
cord-261566-fn08b0y2	332	3	vaccines	vaccine	NNS
cord-261566-fn08b0y2	332	4	induce	induce	VBP
cord-261566-fn08b0y2	332	5	similar	similar	JJ
cord-261566-fn08b0y2	332	6	humoral	humoral	JJ
cord-261566-fn08b0y2	332	7	responses	response	NNS
cord-261566-fn08b0y2	332	8	,	,	,
cord-261566-fn08b0y2	332	9	but	but	CC
cord-261566-fn08b0y2	332	10	only	only	RB
cord-261566-fn08b0y2	332	11	live	live	RB
cord-261566-fn08b0y2	333	1	vaccines	vaccine	NNS
cord-261566-fn08b0y2	333	2	induce	induce	VBP
cord-261566-fn08b0y2	333	3	diverse	diverse	JJ
cord-261566-fn08b0y2	333	4	t	t	NN
cord-261566-fn08b0y2	333	5	-	-	HYPH
cord-261566-fn08b0y2	333	6	cell	cell	NN
cord-261566-fn08b0y2	333	7	responses	response	NNS
cord-261566-fn08b0y2	333	8	in	in	IN
cord-261566-fn08b0y2	333	9	young	young	JJ
cord-261566-fn08b0y2	333	10	children	child	NNS
cord-261566-fn08b0y2	333	11	Development	development	NN
cord-261566-fn08b0y2	333	12	and	and	CC
cord-261566-fn08b0y2	333	13	persistence	persistence	NN
cord-261566-fn08b0y2	333	14	of	of	IN
cord-261566-fn08b0y2	333	15	local	local	JJ
cord-261566-fn08b0y2	333	16	and	and	CC
cord-261566-fn08b0y2	333	17	systemic	systemic	JJ
cord-261566-fn08b0y2	333	18	antibody	antibody	NN
cord-261566-fn08b0y2	333	19	responses	response	NNS
cord-261566-fn08b0y2	333	20	in	in	IN
cord-261566-fn08b0y2	333	21	adults	adult	NNS
cord-261566-fn08b0y2	333	22	given	give	VBN
cord-261566-fn08b0y2	333	23	live	live	VBP
cord-261566-fn08b0y2	333	24	attenuated	attenuate	VBN
cord-261566-fn08b0y2	333	25	or	or	CC
cord-261566-fn08b0y2	333	26	inactivated	inactivate	VBN
cord-261566-fn08b0y2	333	27	influenza	influenza	NN
cord-261566-fn08b0y2	333	28	A	a	DT
cord-261566-fn08b0y2	333	29	virus	virus	NN
cord-261566-fn08b0y2	333	30	vaccine	vaccine	NN
cord-261566-fn08b0y2	333	31	Comparative	comparative	JJ
cord-261566-fn08b0y2	333	32	efficacy	efficacy	NN
cord-261566-fn08b0y2	333	33	of	of	IN
cord-261566-fn08b0y2	333	34	inactivated	inactivate	VBN
cord-261566-fn08b0y2	333	35	and	and	CC
cord-261566-fn08b0y2	333	36	live	live	VB
cord-261566-fn08b0y2	333	37	attenuated	attenuated	JJ
cord-261566-fn08b0y2	333	38	influenza	influenza	NN
cord-261566-fn08b0y2	333	39	vaccines	vaccine	NNS
cord-261566-fn08b0y2	333	40	Live	live	VBP
cord-261566-fn08b0y2	333	41	attenuated	attenuated	JJ
cord-261566-fn08b0y2	333	42	versus	versus	IN
cord-261566-fn08b0y2	333	43	inactivated	inactivate	VBN
cord-261566-fn08b0y2	333	44	influenza	influenza	NN
cord-261566-fn08b0y2	333	45	vaccine	vaccine	NN
cord-261566-fn08b0y2	333	46	in	in	IN
cord-261566-fn08b0y2	333	47	infants	infant	NNS
cord-261566-fn08b0y2	333	48	and	and	CC
cord-261566-fn08b0y2	333	49	young	young	JJ
cord-261566-fn08b0y2	333	50	children	child	NNS
cord-261566-fn08b0y2	333	51	Current	current	JJ
cord-261566-fn08b0y2	333	52	status	status	NN
cord-261566-fn08b0y2	333	53	of	of	IN
cord-261566-fn08b0y2	333	54	live	live	JJ
cord-261566-fn08b0y2	333	55	attenuated	attenuated	JJ
cord-261566-fn08b0y2	333	56	influenza	influenza	NN
cord-261566-fn08b0y2	333	57	vaccine	vaccine	NN
cord-261566-fn08b0y2	333	58	in	in	IN
cord-261566-fn08b0y2	333	59	the	the	DT
cord-261566-fn08b0y2	333	60	United	United	NNP
cord-261566-fn08b0y2	333	61	States	States	NNP
cord-261566-fn08b0y2	333	62	for	for	IN
cord-261566-fn08b0y2	334	1	seasonal	seasonal	JJ
cord-261566-fn08b0y2	334	2	and	and	CC
cord-261566-fn08b0y2	334	3	pandemic	pandemic	NN
cord-261566-fn08b0y2	334	4	influenza	influenza	NN
cord-261566-fn08b0y2	334	5	Mucosal	Mucosal	NNP
cord-261566-fn08b0y2	334	6	Immunity	Immunity	NNP
cord-261566-fn08b0y2	334	7	Induced	induce	VBN
cord-261566-fn08b0y2	334	8	by	by	IN
cord-261566-fn08b0y2	334	9	Enhanced	Enhanced	NNP
cord-261566-fn08b0y2	334	10	-	-	HYPH
cord-261566-fn08b0y2	334	11	Potency	Potency	NNP
cord-261566-fn08b0y2	334	12	Inactivated	inactivate	VBN
cord-261566-fn08b0y2	334	13	and	and	CC
cord-261566-fn08b0y2	334	14	Oral	oral	JJ
cord-261566-fn08b0y2	335	1	Polio	Polio	NNP
cord-261566-fn08b0y2	335	2	Vaccines	Vaccines	NNPS
cord-261566-fn08b0y2	335	3	Immunoglobulin	Immunoglobulin	NNP
cord-261566-fn08b0y2	335	4	response	response	NN
cord-261566-fn08b0y2	335	5	in	in	IN
cord-261566-fn08b0y2	335	6	serum	serum	NN
cord-261566-fn08b0y2	335	7	and	and	CC
cord-261566-fn08b0y2	335	8	secretions	secretion	NNS
cord-261566-fn08b0y2	335	9	after	after	IN
cord-261566-fn08b0y2	335	10	immunization	immunization	NN
cord-261566-fn08b0y2	335	11	with	with	IN
cord-261566-fn08b0y2	335	12	live	live	JJ
cord-261566-fn08b0y2	335	13	and	and	CC
cord-261566-fn08b0y2	335	14	inactivated	inactivate	VBN
cord-261566-fn08b0y2	335	15	poliovaccine	poliovaccine	NN
cord-261566-fn08b0y2	335	16	and	and	CC
cord-261566-fn08b0y2	335	17	natural	natural	JJ
cord-261566-fn08b0y2	335	18	infection	infection	NN
cord-261566-fn08b0y2	335	19	Vaccine	Vaccine	NNP
cord-261566-fn08b0y2	335	20	policy	policy	NN
cord-261566-fn08b0y2	335	21	changes	change	NNS
cord-261566-fn08b0y2	335	22	and	and	CC
cord-261566-fn08b0y2	335	23	epidemiology	epidemiology	NN
cord-261566-fn08b0y2	335	24	of	of	IN
cord-261566-fn08b0y2	335	25	poliomyelitis	poliomyelitis	NN
cord-261566-fn08b0y2	335	26	in	in	IN
cord-261566-fn08b0y2	335	27	the	the	DT
cord-261566-fn08b0y2	335	28	United	United	NNP
cord-261566-fn08b0y2	335	29	States	States	NNP
cord-261566-fn08b0y2	335	30	Polio	Polio	NNP
cord-261566-fn08b0y2	335	31	vaccination	vaccination	NN
cord-261566-fn08b0y2	335	32	:	:	:
cord-261566-fn08b0y2	336	1	past	past	JJ
cord-261566-fn08b0y2	336	2	,	,	,
cord-261566-fn08b0y2	336	3	present	present	JJ
cord-261566-fn08b0y2	336	4	and	and	CC
cord-261566-fn08b0y2	336	5	future	future	JJ
cord-261566-fn08b0y2	336	6	Immunogenicity	immunogenicity	NN
cord-261566-fn08b0y2	336	7	of	of	IN
cord-261566-fn08b0y2	336	8	a	a	DT
cord-261566-fn08b0y2	336	9	DNA	dna	NN
cord-261566-fn08b0y2	336	10	vaccine	vaccine	NN
cord-261566-fn08b0y2	336	11	candidate	candidate	NN
cord-261566-fn08b0y2	336	12	for	for	IN
cord-261566-fn08b0y2	336	13	COVID-19	COVID-19	NNP
cord-261566-fn08b0y2	336	14	An	An	NNP
cord-261566-fn08b0y2	336	15	mRNA	mRNA	NNP
cord-261566-fn08b0y2	336	16	vaccine	vaccine	NN
cord-261566-fn08b0y2	336	17	against	against	IN
cord-261566-fn08b0y2	336	18	SARS	SARS	NNP
cord-261566-fn08b0y2	336	19	-	-	HYPH
cord-261566-fn08b0y2	336	20	CoV-2-preliminary	CoV-2-preliminary	NNP
cord-261566-fn08b0y2	336	21	report	report	NN
cord-261566-fn08b0y2	336	22	ChAdOx1	ChAdOx1	NNP
cord-261566-fn08b0y2	336	23	nCoV-19	ncov-19	DT
cord-261566-fn08b0y2	336	24	vaccination	vaccination	NN
cord-261566-fn08b0y2	336	25	prevents	prevent	VBZ
cord-261566-fn08b0y2	336	26	SARS	SARS	NNP
cord-261566-fn08b0y2	336	27	-	-	HYPH
cord-261566-fn08b0y2	336	28	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	336	29	pneumonia	pneumonia	NN
cord-261566-fn08b0y2	336	30	in	in	IN
cord-261566-fn08b0y2	336	31	rhesus	rhesu	NNS
cord-261566-fn08b0y2	336	32	macaques	macaque	NNS
cord-261566-fn08b0y2	336	33	Development	Development	NNP
cord-261566-fn08b0y2	336	34	of	of	IN
cord-261566-fn08b0y2	336	35	an	an	DT
cord-261566-fn08b0y2	336	36	inactivated	inactivated	JJ
cord-261566-fn08b0y2	336	37	vaccine	vaccine	NN
cord-261566-fn08b0y2	336	38	candidate	candidate	NN
cord-261566-fn08b0y2	336	39	for	for	IN
cord-261566-fn08b0y2	336	40	SARS	SARS	NNP
cord-261566-fn08b0y2	336	41	-	-	HYPH
cord-261566-fn08b0y2	336	42	CoV-2	CoV-2	NNP
cord-261566-fn08b0y2	336	43	.	.	.
cord-261566-fn08b0y2	337	1	Science	science	NN
cord-261566-fn08b0y2	337	2	.	.	.
cord-261566-fn08b0y2	338	1	2020	2020	CD
cord-261566-fn08b0y2	339	1	Microneedle	Microneedle	NNP
cord-261566-fn08b0y2	339	2	array	array	NN
cord-261566-fn08b0y2	339	3	delivered	deliver	VBD
cord-261566-fn08b0y2	339	4	recombinant	recombinant	JJ
cord-261566-fn08b0y2	339	5	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	339	6	vaccines	vaccine	NNS
cord-261566-fn08b0y2	339	7	:	:	:
cord-261566-fn08b0y2	340	1	immunogenicity	immunogenicity	JJ
cord-261566-fn08b0y2	340	2	and	and	CC
cord-261566-fn08b0y2	340	3	rapid	rapid	JJ
cord-261566-fn08b0y2	340	4	translational	translational	JJ
cord-261566-fn08b0y2	340	5	development	development	NN
cord-261566-fn08b0y2	340	6	Human	Human	NNP
cord-261566-fn08b0y2	340	7	challenge	challenge	NN
cord-261566-fn08b0y2	340	8	studies	study	NNS
cord-261566-fn08b0y2	340	9	to	to	TO
cord-261566-fn08b0y2	340	10	accelerate	accelerate	VB
cord-261566-fn08b0y2	340	11	coronavirus	coronavirus	NN
cord-261566-fn08b0y2	340	12	vaccine	vaccine	NN
cord-261566-fn08b0y2	340	13	licensure	licensure	NN
cord-261566-fn08b0y2	340	14	Developing	develop	VBG
cord-261566-fn08b0y2	340	15	Covid-19	covid-19	JJ
cord-261566-fn08b0y2	340	16	vaccines	vaccine	NNS
cord-261566-fn08b0y2	340	17	at	at	IN
cord-261566-fn08b0y2	340	18	pandemic	pandemic	NN
cord-261566-fn08b0y2	340	19	speed	speed	NN
cord-261566-fn08b0y2	341	1	An	an	DT
cord-261566-fn08b0y2	341	2	improved	improved	JJ
cord-261566-fn08b0y2	341	3	reverse	reverse	JJ
cord-261566-fn08b0y2	341	4	genetics	genetics	NN
cord-261566-fn08b0y2	341	5	system	system	NN
cord-261566-fn08b0y2	341	6	for	for	IN
cord-261566-fn08b0y2	341	7	influenza	influenza	NN
cord-261566-fn08b0y2	341	8	A	a	DT
cord-261566-fn08b0y2	341	9	virus	virus	NN
cord-261566-fn08b0y2	341	10	generation	generation	NN
cord-261566-fn08b0y2	341	11	and	and	CC
cord-261566-fn08b0y2	341	12	its	-PRON-	PRP$
cord-261566-fn08b0y2	341	13	implications	implication	NNS
cord-261566-fn08b0y2	341	14	for	for	IN
cord-261566-fn08b0y2	341	15	vaccine	vaccine	NN
cord-261566-fn08b0y2	341	16	production	production	NN