id	sid	tid	token	lemma	pos
cord-259347-3acsko74	1	1	key	key	JJ
cord-259347-3acsko74	1	2	:	:	:
cord-259347-3acsko74	1	3	cord-259347	cord-259347	NN
cord-259347-3acsko74	1	4	-	-	HYPH
cord-259347-3acsko74	1	5	3acsko74	3acsko74	CD
cord-259347-3acsko74	2	1	authors	author	NNS
cord-259347-3acsko74	2	2	:	:	:
cord-259347-3acsko74	2	3	Cheng	Cheng	NNP
cord-259347-3acsko74	2	4	,	,	,
cord-259347-3acsko74	2	5	Qi	Qi	NNP
cord-259347-3acsko74	2	6	;	;	:
cord-259347-3acsko74	2	7	Yang	Yang	NNP
cord-259347-3acsko74	2	8	,	,	,
cord-259347-3acsko74	2	9	Yue	Yue	NNP
cord-259347-3acsko74	2	10	;	;	:
cord-259347-3acsko74	2	11	Gao	Gao	NNP
cord-259347-3acsko74	2	12	,	,	,
cord-259347-3acsko74	2	13	Jianqun	Jianqun	NNP
cord-259347-3acsko74	2	14	title	title	NN
cord-259347-3acsko74	2	15	:	:	:
cord-259347-3acsko74	2	16	Infectivity	infectivity	NN
cord-259347-3acsko74	2	17	of	of	IN
cord-259347-3acsko74	2	18	human	human	JJ
cord-259347-3acsko74	2	19	coronavirus	coronavirus	NN
cord-259347-3acsko74	2	20	in	in	IN
cord-259347-3acsko74	2	21	the	the	DT
cord-259347-3acsko74	2	22	brain	brain	NN
cord-259347-3acsko74	2	23	date	date	NN
cord-259347-3acsko74	2	24	:	:	:
cord-259347-3acsko74	2	25	2020	2020	CD
cord-259347-3acsko74	2	26	-	-	HYPH
cord-259347-3acsko74	2	27	05	05	CD
cord-259347-3acsko74	2	28	-	-	HYPH
cord-259347-3acsko74	2	29	28	28	CD
cord-259347-3acsko74	2	30	journal	journal	NN
cord-259347-3acsko74	2	31	:	:	:
cord-259347-3acsko74	3	1	EBioMedicine	ebiomedicine	NN
cord-259347-3acsko74	3	2	DOI	DOI	NNP
cord-259347-3acsko74	3	3	:	:	:
cord-259347-3acsko74	3	4	10.1016	10.1016	CD
cord-259347-3acsko74	3	5	/	/	SYM
cord-259347-3acsko74	3	6	j.ebiom.2020.102799	j.ebiom.2020.102799	NN
cord-259347-3acsko74	3	7	sha	sha	NNP
cord-259347-3acsko74	3	8	:	:	:
cord-259347-3acsko74	4	1	100a54809072039c7ae8e82d62803683ccbf548c	100a54809072039c7ae8e82d62803683ccbf548c	CD
cord-259347-3acsko74	5	1	doc_id	doc_id	LS
cord-259347-3acsko74	5	2	:	:	:
cord-259347-3acsko74	5	3	259347	259347	CD
cord-259347-3acsko74	5	4	cord_uid	cord_uid	NNS
cord-259347-3acsko74	5	5	:	:	:
cord-259347-3acsko74	5	6	3acsko74	3acsko74	CD
cord-259347-3acsko74	5	7	A	a	DT
cord-259347-3acsko74	5	8	new	new	JJ
cord-259347-3acsko74	5	9	strain	strain	NN
cord-259347-3acsko74	5	10	of	of	IN
cord-259347-3acsko74	5	11	human	human	JJ
cord-259347-3acsko74	5	12	coronaviruses	coronaviruse	NNS
cord-259347-3acsko74	5	13	(	(	-LRB-
cord-259347-3acsko74	5	14	hCoVs	hCoVs	NNP
cord-259347-3acsko74	5	15	)	)	-RRB-
cord-259347-3acsko74	5	16	,	,	.
cord-259347-3acsko74	6	1	Severe	severe	JJ
cord-259347-3acsko74	6	2	Acute	acute	JJ
cord-259347-3acsko74	6	3	Respiratory	respiratory	JJ
cord-259347-3acsko74	6	4	Syndrome	syndrome	NN
cord-259347-3acsko74	6	5	Coronavirus-2	Coronavirus-2	NNP
cord-259347-3acsko74	7	1	(	(	-LRB-
cord-259347-3acsko74	7	2	SARS	SARS	NNP
cord-259347-3acsko74	7	3	-	-	HYPH
cord-259347-3acsko74	7	4	CoV-2	CoV-2	NNP
cord-259347-3acsko74	7	5	)	)	-RRB-
cord-259347-3acsko74	7	6	,	,	,
cord-259347-3acsko74	7	7	has	have	VBZ
cord-259347-3acsko74	7	8	been	be	VBN
cord-259347-3acsko74	7	9	identified	identify	VBN
cord-259347-3acsko74	7	10	to	to	TO
cord-259347-3acsko74	7	11	be	be	VB
cord-259347-3acsko74	7	12	responsible	responsible	JJ
cord-259347-3acsko74	7	13	for	for	IN
cord-259347-3acsko74	7	14	the	the	DT
cord-259347-3acsko74	7	15	current	current	JJ
cord-259347-3acsko74	7	16	outbreak	outbreak	NN
cord-259347-3acsko74	7	17	of	of	IN
cord-259347-3acsko74	7	18	the	the	DT
cord-259347-3acsko74	7	19	coronavirus	coronavirus	NN
cord-259347-3acsko74	7	20	disease	disease	NN
cord-259347-3acsko74	7	21	2019	2019	CD
cord-259347-3acsko74	7	22	(	(	-LRB-
cord-259347-3acsko74	7	23	COVID-19	COVID-19	NNP
cord-259347-3acsko74	7	24	)	)	-RRB-
cord-259347-3acsko74	7	25	.	.	.
cord-259347-3acsko74	8	1	Though	though	IN
cord-259347-3acsko74	8	2	major	major	JJ
cord-259347-3acsko74	8	3	symptoms	symptom	NNS
cord-259347-3acsko74	8	4	are	be	VBP
cord-259347-3acsko74	8	5	primarily	primarily	RB
cord-259347-3acsko74	8	6	generated	generate	VBN
cord-259347-3acsko74	8	7	from	from	IN
cord-259347-3acsko74	8	8	the	the	DT
cord-259347-3acsko74	8	9	respiratory	respiratory	JJ
cord-259347-3acsko74	8	10	system	system	NN
cord-259347-3acsko74	8	11	,	,	,
cord-259347-3acsko74	8	12	neurological	neurological	JJ
cord-259347-3acsko74	8	13	symptoms	symptom	NNS
cord-259347-3acsko74	8	14	are	be	VBP
cord-259347-3acsko74	8	15	being	be	VBG
cord-259347-3acsko74	8	16	reported	report	VBN
cord-259347-3acsko74	8	17	in	in	IN
cord-259347-3acsko74	8	18	some	some	DT
cord-259347-3acsko74	8	19	of	of	IN
cord-259347-3acsko74	8	20	the	the	DT
cord-259347-3acsko74	8	21	confirmed	confirm	VBN
cord-259347-3acsko74	8	22	cases	case	NNS
cord-259347-3acsko74	8	23	,	,	,
cord-259347-3acsko74	8	24	raising	raise	VBG
cord-259347-3acsko74	8	25	concerns	concern	NNS
cord-259347-3acsko74	8	26	of	of	IN
cord-259347-3acsko74	8	27	its	-PRON-	PRP$
cord-259347-3acsko74	8	28	potential	potential	NN
cord-259347-3acsko74	8	29	for	for	IN
cord-259347-3acsko74	8	30	intracranial	intracranial	JJ
cord-259347-3acsko74	8	31	invasion	invasion	NN
cord-259347-3acsko74	8	32	and	and	CC
cord-259347-3acsko74	8	33	neurological	neurological	JJ
cord-259347-3acsko74	8	34	manifestations	manifestation	NNS
cord-259347-3acsko74	8	35	,	,	,
cord-259347-3acsko74	8	36	both	both	CC
cord-259347-3acsko74	8	37	in	in	IN
cord-259347-3acsko74	8	38	the	the	DT
cord-259347-3acsko74	8	39	acute	acute	JJ
cord-259347-3acsko74	8	40	phase	phase	NN
cord-259347-3acsko74	8	41	and	and	CC
cord-259347-3acsko74	8	42	in	in	IN
cord-259347-3acsko74	8	43	the	the	DT
cord-259347-3acsko74	8	44	long	long	JJ
cord-259347-3acsko74	8	45	-	-	HYPH
cord-259347-3acsko74	8	46	term	term	NN
cord-259347-3acsko74	8	47	.	.	.
cord-259347-3acsko74	9	1	At	at	IN
cord-259347-3acsko74	9	2	present	present	NN
cord-259347-3acsko74	9	3	,	,	,
cord-259347-3acsko74	9	4	it	-PRON-	PRP
cord-259347-3acsko74	9	5	remains	remain	VBZ
cord-259347-3acsko74	9	6	unclear	unclear	JJ
cord-259347-3acsko74	9	7	the	the	DT
cord-259347-3acsko74	9	8	extent	extent	NN
cord-259347-3acsko74	9	9	to	to	TO
cord-259347-3acsko74	9	10	which	which	WDT
cord-259347-3acsko74	9	11	SARS	SARS	NNP
cord-259347-3acsko74	9	12	-	-	HYPH
cord-259347-3acsko74	9	13	CoV-2	CoV-2	NNP
cord-259347-3acsko74	9	14	is	be	VBZ
cord-259347-3acsko74	9	15	present	present	JJ
cord-259347-3acsko74	9	16	in	in	IN
cord-259347-3acsko74	9	17	the	the	DT
cord-259347-3acsko74	9	18	brain	brain	NN
cord-259347-3acsko74	9	19	,	,	,
cord-259347-3acsko74	9	20	and	and	CC
cord-259347-3acsko74	9	21	if	if	IN
cord-259347-3acsko74	9	22	so	so	RB
cord-259347-3acsko74	9	23	,	,	,
cord-259347-3acsko74	9	24	its	-PRON-	PRP$
cord-259347-3acsko74	9	25	pathogenic	pathogenic	JJ
cord-259347-3acsko74	9	26	role	role	NN
cord-259347-3acsko74	9	27	in	in	IN
cord-259347-3acsko74	9	28	the	the	DT
cord-259347-3acsko74	9	29	central	central	JJ
cord-259347-3acsko74	9	30	nervous	nervous	JJ
cord-259347-3acsko74	9	31	system	system	NN
cord-259347-3acsko74	9	32	(	(	-LRB-
cord-259347-3acsko74	9	33	CNS	CNS	NNP
cord-259347-3acsko74	9	34	)	)	-RRB-
cord-259347-3acsko74	9	35	.	.	.
cord-259347-3acsko74	10	1	Evidence	evidence	NN
cord-259347-3acsko74	10	2	for	for	IN
cord-259347-3acsko74	10	3	neuroinvasion	neuroinvasion	NN
cord-259347-3acsko74	10	4	and	and	CC
cord-259347-3acsko74	10	5	neurovirulence	neurovirulence	NN
cord-259347-3acsko74	10	6	of	of	IN
cord-259347-3acsko74	10	7	hCoVs	hCoVs	NNP
cord-259347-3acsko74	10	8	has	have	VBZ
cord-259347-3acsko74	10	9	been	be	VBN
cord-259347-3acsko74	10	10	recognised	recognise	VBN
cord-259347-3acsko74	10	11	in	in	IN
cord-259347-3acsko74	10	12	animal	animal	NN
cord-259347-3acsko74	10	13	and	and	CC
cord-259347-3acsko74	10	14	human	human	JJ
cord-259347-3acsko74	10	15	studies	study	NNS
cord-259347-3acsko74	10	16	.	.	.
cord-259347-3acsko74	11	1	Given	give	VBN
cord-259347-3acsko74	11	2	that	that	IN
cord-259347-3acsko74	11	3	SARS	SARS	NNP
cord-259347-3acsko74	11	4	-	-	HYPH
cord-259347-3acsko74	11	5	CoV-2	CoV-2	NNP
cord-259347-3acsko74	11	6	belongs	belong	VBZ
cord-259347-3acsko74	11	7	to	to	IN
cord-259347-3acsko74	11	8	the	the	DT
cord-259347-3acsko74	11	9	same	same	JJ
cord-259347-3acsko74	11	10	family	family	NN
cord-259347-3acsko74	11	11	and	and	CC
cord-259347-3acsko74	11	12	shares	share	NNS
cord-259347-3acsko74	11	13	characteristics	characteristic	NNS
cord-259347-3acsko74	11	14	in	in	IN
cord-259347-3acsko74	11	15	terms	term	NNS
cord-259347-3acsko74	11	16	of	of	IN
cord-259347-3acsko74	11	17	receptor	receptor	NN
cord-259347-3acsko74	11	18	binding	bind	VBG
cord-259347-3acsko74	11	19	properties	property	NNS
cord-259347-3acsko74	11	20	,	,	,
cord-259347-3acsko74	11	21	it	-PRON-	PRP
cord-259347-3acsko74	11	22	is	be	VBZ
cord-259347-3acsko74	11	23	worthwhile	worthwhile	JJ
cord-259347-3acsko74	11	24	exploring	explore	VBG
cord-259347-3acsko74	11	25	its	-PRON-	PRP$
cord-259347-3acsko74	11	26	potential	potential	JJ
cord-259347-3acsko74	11	27	CNS	CNS	NNP
cord-259347-3acsko74	11	28	manifestations	manifestation	NNS
cord-259347-3acsko74	11	29	.	.	.
cord-259347-3acsko74	12	1	This	this	DT
cord-259347-3acsko74	12	2	review	review	NN
cord-259347-3acsko74	12	3	summarises	summarise	VBZ
cord-259347-3acsko74	12	4	previous	previous	JJ
cord-259347-3acsko74	12	5	findings	finding	NNS
cord-259347-3acsko74	12	6	from	from	IN
cord-259347-3acsko74	12	7	hCoVs	hCoVs	NNP
cord-259347-3acsko74	12	8	in	in	IN
cord-259347-3acsko74	12	9	relation	relation	NN
cord-259347-3acsko74	12	10	to	to	IN
cord-259347-3acsko74	12	11	the	the	DT
cord-259347-3acsko74	12	12	CNS	CNS	NNP
cord-259347-3acsko74	12	13	,	,	,
cord-259347-3acsko74	12	14	and	and	CC
cord-259347-3acsko74	12	15	compares	compare	VBZ
cord-259347-3acsko74	12	16	these	these	DT
cord-259347-3acsko74	12	17	with	with	IN
cord-259347-3acsko74	12	18	the	the	DT
cord-259347-3acsko74	12	19	new	new	JJ
cord-259347-3acsko74	12	20	strain	strain	NN
cord-259347-3acsko74	12	21	,	,	,
cord-259347-3acsko74	12	22	aiming	aim	VBG
cord-259347-3acsko74	12	23	to	to	TO
cord-259347-3acsko74	12	24	provide	provide	VB
cord-259347-3acsko74	12	25	a	a	DT
cord-259347-3acsko74	12	26	better	well	JJR
cord-259347-3acsko74	12	27	understanding	understanding	NN
cord-259347-3acsko74	12	28	of	of	IN
cord-259347-3acsko74	12	29	the	the	DT
cord-259347-3acsko74	12	30	effects	effect	NNS
cord-259347-3acsko74	12	31	of	of	IN
cord-259347-3acsko74	12	32	SARS	SARS	NNP
cord-259347-3acsko74	12	33	-	-	HYPH
cord-259347-3acsko74	12	34	CoV-2	CoV-2	NNP
cord-259347-3acsko74	12	35	on	on	IN
cord-259347-3acsko74	12	36	the	the	DT
cord-259347-3acsko74	12	37	CNS	CNS	NNP
cord-259347-3acsko74	12	38	.	.	.
cord-259347-3acsko74	13	1	Human	human	JJ
cord-259347-3acsko74	13	2	coronaviruses	coronaviruse	NNS
cord-259347-3acsko74	13	3	(	(	-LRB-
cord-259347-3acsko74	13	4	hCoVs	hCoVs	NNP
cord-259347-3acsko74	13	5	)	)	-RRB-
cord-259347-3acsko74	13	6	are	be	VBP
cord-259347-3acsko74	13	7	a	a	DT
cord-259347-3acsko74	13	8	group	group	NN
cord-259347-3acsko74	13	9	of	of	IN
cord-259347-3acsko74	13	10	enveloped	envelop	VBN
cord-259347-3acsko74	13	11	RNA	RNA	NNP
cord-259347-3acsko74	13	12	viruses	virus	NNS
cord-259347-3acsko74	13	13	that	that	WDT
cord-259347-3acsko74	13	14	are	be	VBP
cord-259347-3acsko74	13	15	composed	compose	VBN
cord-259347-3acsko74	13	16	of	of	IN
cord-259347-3acsko74	13	17	a	a	DT
cord-259347-3acsko74	13	18	single	single	JJ
cord-259347-3acsko74	13	19	stranded	strand	VBN
cord-259347-3acsko74	13	20	positive	positive	JJ
cord-259347-3acsko74	13	21	sense	sense	NN
cord-259347-3acsko74	13	22	RNA	RNA	NNP
cord-259347-3acsko74	13	23	genome	genome	NN
cord-259347-3acsko74	13	24	(	(	-LRB-
cord-259347-3acsko74	13	25	~30	~30	NNP
cord-259347-3acsko74	13	26	kb	kb	NNP
cord-259347-3acsko74	13	27	)	)	-RRB-
cord-259347-3acsko74	13	28	.	.	.
cord-259347-3acsko74	14	1	The	the	DT
cord-259347-3acsko74	14	2	entire	entire	JJ
cord-259347-3acsko74	14	3	genome	genome	NN
cord-259347-3acsko74	14	4	of	of	IN
cord-259347-3acsko74	14	5	hCoVs	hCoVs	NNP
cord-259347-3acsko74	14	6	encodes	encode	VBZ
cord-259347-3acsko74	14	7	spike	spike	NN
cord-259347-3acsko74	14	8	(	(	-LRB-
cord-259347-3acsko74	14	9	S	s	NN
cord-259347-3acsko74	14	10	)	)	-RRB-
cord-259347-3acsko74	14	11	glycoprotein	glycoprotein	NN
cord-259347-3acsko74	14	12	,	,	,
cord-259347-3acsko74	14	13	membrane	membrane	NN
cord-259347-3acsko74	14	14	(	(	-LRB-
cord-259347-3acsko74	14	15	M	M	NNP
cord-259347-3acsko74	14	16	)	)	-RRB-
cord-259347-3acsko74	14	17	glycoprotein	glycoprotein	NN
cord-259347-3acsko74	14	18	,	,	,
cord-259347-3acsko74	14	19	envelope	envelope	NN
cord-259347-3acsko74	14	20	(	(	-LRB-
cord-259347-3acsko74	14	21	E	e	NN
cord-259347-3acsko74	14	22	)	)	-RRB-
cord-259347-3acsko74	14	23	glycoprotein	glycoprotein	NN
cord-259347-3acsko74	14	24	,	,	,
cord-259347-3acsko74	14	25	nucleocapsid	nucleocapsid	NN
cord-259347-3acsko74	14	26	(	(	-LRB-
cord-259347-3acsko74	14	27	N	N	NNP
cord-259347-3acsko74	14	28	)	)	-RRB-
cord-259347-3acsko74	14	29	protein	protein	NN
cord-259347-3acsko74	14	30	,	,	,
cord-259347-3acsko74	14	31	RNA	RNA	NNP
cord-259347-3acsko74	14	32	polymerase	polymerase	NN
cord-259347-3acsko74	14	33	and	and	CC
cord-259347-3acsko74	14	34	genes	gene	NNS
cord-259347-3acsko74	14	35	for	for	IN
cord-259347-3acsko74	14	36	numerous	numerous	JJ
cord-259347-3acsko74	14	37	accessory	accessory	JJ
cord-259347-3acsko74	14	38	proteins	protein	NNS
cord-259347-3acsko74	14	39	that	that	WDT
cord-259347-3acsko74	14	40	modulate	modulate	VBP
cord-259347-3acsko74	14	41	pathogenesis	pathogenesis	NN
cord-259347-3acsko74	14	42	,	,	,
cord-259347-3acsko74	14	43	among	among	IN
cord-259347-3acsko74	14	44	which	which	WDT
cord-259347-3acsko74	14	45	the	the	DT
cord-259347-3acsko74	14	46	N	N	NNP
cord-259347-3acsko74	14	47	protein	protein	NN
cord-259347-3acsko74	14	48	is	be	VBZ
cord-259347-3acsko74	14	49	highly	highly	RB
cord-259347-3acsko74	14	50	conserved	conserve	VBN
cord-259347-3acsko74	14	51	in	in	IN
cord-259347-3acsko74	14	52	most	most	JJS
cord-259347-3acsko74	14	53	coronaviruses	coronaviruse	NNS
cord-259347-3acsko74	14	54	and	and	CC
cord-259347-3acsko74	14	55	abundantly	abundantly	RB
cord-259347-3acsko74	14	56	expressed	express	VBN
cord-259347-3acsko74	14	57	during	during	IN
cord-259347-3acsko74	14	58	infection	infection	NN
cord-259347-3acsko74	14	59	[	[	-LRB-
cord-259347-3acsko74	14	60	1	1	CD
cord-259347-3acsko74	14	61	]	]	-RRB-
cord-259347-3acsko74	14	62	,	,	,
cord-259347-3acsko74	14	63	thus	thus	RB
cord-259347-3acsko74	14	64	acting	act	VBG
cord-259347-3acsko74	14	65	as	as	IN
cord-259347-3acsko74	14	66	a	a	DT
cord-259347-3acsko74	14	67	critical	critical	JJ
cord-259347-3acsko74	14	68	antigen	antigen	NN
cord-259347-3acsko74	14	69	for	for	IN
cord-259347-3acsko74	14	70	viral	viral	JJ
cord-259347-3acsko74	14	71	detection	detection	NN
cord-259347-3acsko74	14	72	.	.	.
cord-259347-3acsko74	15	1	The	the	DT
cord-259347-3acsko74	15	2	S	S	NNP
cord-259347-3acsko74	15	3	protein	protein	NN
cord-259347-3acsko74	15	4	is	be	VBZ
cord-259347-3acsko74	15	5	biologically	biologically	RB
cord-259347-3acsko74	15	6	critical	critical	JJ
cord-259347-3acsko74	15	7	for	for	IN
cord-259347-3acsko74	15	8	tropism	tropism	NN
cord-259347-3acsko74	15	9	and	and	CC
cord-259347-3acsko74	15	10	modulation	modulation	NN
cord-259347-3acsko74	15	11	[	[	-LRB-
cord-259347-3acsko74	15	12	2	2	CD
cord-259347-3acsko74	15	13	]	]	-RRB-
cord-259347-3acsko74	15	14	,	,	,
cord-259347-3acsko74	15	15	and	and	CC
cord-259347-3acsko74	15	16	is	be	VBZ
cord-259347-3acsko74	15	17	considered	consider	VBN
cord-259347-3acsko74	15	18	to	to	TO
cord-259347-3acsko74	15	19	be	be	VB
cord-259347-3acsko74	15	20	integral	integral	JJ
cord-259347-3acsko74	15	21	in	in	IN
cord-259347-3acsko74	15	22	the	the	DT
cord-259347-3acsko74	15	23	capability	capability	NN
cord-259347-3acsko74	15	24	of	of	IN
cord-259347-3acsko74	15	25	hCoVs	hCoVs	NNP
cord-259347-3acsko74	15	26	to	to	TO
cord-259347-3acsko74	15	27	reach	reach	VB
cord-259347-3acsko74	15	28	the	the	DT
cord-259347-3acsko74	15	29	brain	brain	NN
cord-259347-3acsko74	15	30	[	[	-LRB-
cord-259347-3acsko74	15	31	3	3	CD
cord-259347-3acsko74	15	32	,	,	,
cord-259347-3acsko74	15	33	4	4	CD
cord-259347-3acsko74	15	34	]	]	-RRB-
cord-259347-3acsko74	15	35	.	.	.
cord-259347-3acsko74	16	1	The	the	DT
cord-259347-3acsko74	16	2	hCoVs	hCoVs	NNP
cord-259347-3acsko74	16	3	include	include	VBP
cord-259347-3acsko74	16	4	seven	seven	CD
cord-259347-3acsko74	16	5	strains	strain	NNS
cord-259347-3acsko74	16	6	,	,	,
cord-259347-3acsko74	16	7	three	three	CD
cord-259347-3acsko74	16	8	of	of	IN
cord-259347-3acsko74	16	9	which	which	WDT
cord-259347-3acsko74	16	10	,	,	,
cord-259347-3acsko74	16	11	namely	namely	RB
cord-259347-3acsko74	16	12	SARS	SARS	NNP
cord-259347-3acsko74	16	13	-	-	HYPH
cord-259347-3acsko74	16	14	CoV-2	CoV-2	NNP
cord-259347-3acsko74	16	15	,	,	,
cord-259347-3acsko74	16	16	SARS	SARS	NNP
cord-259347-3acsko74	16	17	-	-	HYPH
cord-259347-3acsko74	16	18	CoV	CoV	NNP
cord-259347-3acsko74	16	19	,	,	,
cord-259347-3acsko74	16	20	and	and	CC
cord-259347-3acsko74	16	21	Middle	Middle	NNP
cord-259347-3acsko74	16	22	East	East	NNP
cord-259347-3acsko74	16	23	respiratory	respiratory	JJ
cord-259347-3acsko74	16	24	syndrome	syndrome	NN
cord-259347-3acsko74	16	25	-	-	HYPH
cord-259347-3acsko74	16	26	related	relate	VBN
cord-259347-3acsko74	16	27	coronavirus	coronavirus	NN
cord-259347-3acsko74	16	28	(	(	-LRB-
cord-259347-3acsko74	16	29	MERS	MERS	NNP
cord-259347-3acsko74	16	30	-	-	HYPH
cord-259347-3acsko74	16	31	CoV	CoV	NNP
cord-259347-3acsko74	16	32	)	)	-RRB-
cord-259347-3acsko74	16	33	,	,	,
cord-259347-3acsko74	16	34	may	may	MD
cord-259347-3acsko74	16	35	cause	cause	VB
cord-259347-3acsko74	16	36	severe	severe	JJ
cord-259347-3acsko74	16	37	respiratory	respiratory	JJ
cord-259347-3acsko74	16	38	disease	disease	NN
cord-259347-3acsko74	16	39	with	with	IN
cord-259347-3acsko74	16	40	a	a	DT
cord-259347-3acsko74	16	41	relatively	relatively	RB
cord-259347-3acsko74	16	42	high	high	JJ
cord-259347-3acsko74	16	43	morbidity	morbidity	NN
cord-259347-3acsko74	16	44	and	and	CC
cord-259347-3acsko74	16	45	mortality	mortality	NN
cord-259347-3acsko74	16	46	.	.	.
cord-259347-3acsko74	17	1	In	in	IN
cord-259347-3acsko74	17	2	contrast	contrast	NN
cord-259347-3acsko74	17	3	,	,	,
cord-259347-3acsko74	17	4	the	the	DT
cord-259347-3acsko74	17	5	other	other	JJ
cord-259347-3acsko74	17	6	four	four	CD
cord-259347-3acsko74	17	7	strains	strain	NNS
cord-259347-3acsko74	17	8	OC43	OC43	NNP
cord-259347-3acsko74	17	9	,	,	,
cord-259347-3acsko74	17	10	229E	229e	CD
cord-259347-3acsko74	17	11	,	,	,
cord-259347-3acsko74	17	12	NL63	NL63	NNP
cord-259347-3acsko74	17	13	and	and	CC
cord-259347-3acsko74	17	14	HKU1	HKU1	NNP
cord-259347-3acsko74	17	15	,	,	,
cord-259347-3acsko74	17	16	are	be	VBP
cord-259347-3acsko74	17	17	often	often	RB
cord-259347-3acsko74	17	18	associated	associate	VBN
cord-259347-3acsko74	17	19	with	with	IN
cord-259347-3acsko74	17	20	symptoms	symptom	NNS
cord-259347-3acsko74	17	21	akin	akin	JJ
cord-259347-3acsko74	17	22	to	to	IN
cord-259347-3acsko74	17	23	the	the	DT
cord-259347-3acsko74	17	24	'	'	``
cord-259347-3acsko74	17	25	common	common	JJ
cord-259347-3acsko74	17	26	cold	cold	NN
cord-259347-3acsko74	17	27	'	'	''
cord-259347-3acsko74	17	28	and	and	CC
cord-259347-3acsko74	17	29	hence	hence	RB
cord-259347-3acsko74	17	30	,	,	,
cord-259347-3acsko74	17	31	are	be	VBP
cord-259347-3acsko74	17	32	relatively	relatively	RB
cord-259347-3acsko74	17	33	harmless	harmless	JJ
cord-259347-3acsko74	17	34	.	.	.
cord-259347-3acsko74	18	1	Based	base	VBN
cord-259347-3acsko74	18	2	on	on	IN
cord-259347-3acsko74	18	3	genome	genome	NN
cord-259347-3acsko74	18	4	analysis	analysis	NN
cord-259347-3acsko74	18	5	,	,	,
cord-259347-3acsko74	18	6	the	the	DT
cord-259347-3acsko74	18	7	OC43	OC43	NNP
cord-259347-3acsko74	18	8	strain	strain	NN
cord-259347-3acsko74	18	9	shares	share	NNS
cord-259347-3acsko74	18	10	a	a	DT
cord-259347-3acsko74	18	11	531	531	CD
cord-259347-3acsko74	18	12	%	%	NN
cord-259347-3acsko74	18	13	and	and	CC
cord-259347-3acsko74	18	14	a	a	DT
cord-259347-3acsko74	18	15	512	512	CD
cord-259347-3acsko74	18	16	%	%	NN
cord-259347-3acsko74	18	17	identity	identity	NN
cord-259347-3acsko74	18	18	with	with	IN
cord-259347-3acsko74	18	19	SARS	SARS	NNP
cord-259347-3acsko74	18	20	-	-	HYPH
cord-259347-3acsko74	18	21	CoV	CoV	NNP
cord-259347-3acsko74	18	22	and	and	CC
cord-259347-3acsko74	18	23	hCoV-229E	hCoV-229E	NNP
cord-259347-3acsko74	18	24	,	,	,
cord-259347-3acsko74	18	25	respectively	respectively	RB
cord-259347-3acsko74	18	26	[	[	-LRB-
cord-259347-3acsko74	18	27	5	5	CD
cord-259347-3acsko74	18	28	]	]	-RRB-
cord-259347-3acsko74	18	29	.	.	.
cord-259347-3acsko74	19	1	The	the	DT
cord-259347-3acsko74	19	2	new	new	JJ
cord-259347-3acsko74	19	3	strain	strain	NN
cord-259347-3acsko74	19	4	,	,	,
cord-259347-3acsko74	19	5	SARS	SARS	NNP
cord-259347-3acsko74	19	6	-	-	HYPH
cord-259347-3acsko74	19	7	CoV-2	CoV-2	NNP
cord-259347-3acsko74	19	8	(	(	-LRB-
cord-259347-3acsko74	19	9	previously	previously	RB
cord-259347-3acsko74	19	10	called	call	VBN
cord-259347-3acsko74	19	11	2019-CoV	2019-cov	CD
cord-259347-3acsko74	19	12	)	)	-RRB-
cord-259347-3acsko74	19	13	,	,	,
cord-259347-3acsko74	19	14	shares	share	VBZ
cord-259347-3acsko74	19	15	a	a	DT
cord-259347-3acsko74	19	16	79	79	CD
cord-259347-3acsko74	19	17	%	%	NN
cord-259347-3acsko74	19	18	and	and	CC
cord-259347-3acsko74	19	19	50	50	CD
cord-259347-3acsko74	19	20	%	%	NN
cord-259347-3acsko74	19	21	identity	identity	NN
cord-259347-3acsko74	19	22	with	with	IN
cord-259347-3acsko74	19	23	SARS	SARS	NNP
cord-259347-3acsko74	19	24	-	-	HYPH
cord-259347-3acsko74	19	25	CoV	CoV	NNP
cord-259347-3acsko74	19	26	and	and	CC
cord-259347-3acsko74	19	27	MERS	MERS	NNP
cord-259347-3acsko74	19	28	-	-	HYPH
cord-259347-3acsko74	19	29	CoV	CoV	NNP
cord-259347-3acsko74	19	30	,	,	,
cord-259347-3acsko74	19	31	respectively	respectively	RB
cord-259347-3acsko74	19	32	[	[	-LRB-
cord-259347-3acsko74	19	33	6	6	CD
cord-259347-3acsko74	19	34	]	]	-RRB-
cord-259347-3acsko74	19	35	.	.	.
cord-259347-3acsko74	20	1	Mainly	mainly	RB
cord-259347-3acsko74	20	2	considered	consider	VBN
cord-259347-3acsko74	20	3	as	as	IN
cord-259347-3acsko74	20	4	respiratory	respiratory	JJ
cord-259347-3acsko74	20	5	viruses	virus	NNS
cord-259347-3acsko74	20	6	,	,	,
cord-259347-3acsko74	20	7	a	a	DT
cord-259347-3acsko74	20	8	common	common	JJ
cord-259347-3acsko74	20	9	manifestation	manifestation	NN
cord-259347-3acsko74	20	10	from	from	IN
cord-259347-3acsko74	20	11	hCoVs	hCoVs	NNP
cord-259347-3acsko74	20	12	related	relate	VBN
cord-259347-3acsko74	20	13	acute	acute	JJ
cord-259347-3acsko74	20	14	respiratory	respiratory	JJ
cord-259347-3acsko74	20	15	disease	disease	NN
cord-259347-3acsko74	20	16	is	be	VBZ
cord-259347-3acsko74	20	17	hypoxia	hypoxia	NN
cord-259347-3acsko74	20	18	,	,	,
cord-259347-3acsko74	20	19	which	which	WDT
cord-259347-3acsko74	20	20	predisposes	predispose	VBZ
cord-259347-3acsko74	20	21	the	the	DT
cord-259347-3acsko74	20	22	brain	brain	NN
cord-259347-3acsko74	20	23	to	to	IN
cord-259347-3acsko74	20	24	edema	edema	NN
cord-259347-3acsko74	20	25	,	,	,
cord-259347-3acsko74	20	26	disturbed	disturbed	JJ
cord-259347-3acsko74	20	27	metabolism	metabolism	NN
cord-259347-3acsko74	20	28	,	,	,
cord-259347-3acsko74	20	29	and	and	CC
cord-259347-3acsko74	20	30	subsequent	subsequent	JJ
cord-259347-3acsko74	20	31	neurological	neurological	JJ
cord-259347-3acsko74	20	32	manifestation	manifestation	NN
cord-259347-3acsko74	20	33	.	.	.
cord-259347-3acsko74	21	1	However	however	RB
cord-259347-3acsko74	21	2	,	,	,
cord-259347-3acsko74	21	3	hypoxia	hypoxia	NN
cord-259347-3acsko74	21	4	is	be	VBZ
cord-259347-3acsko74	21	5	not	not	RB
cord-259347-3acsko74	21	6	the	the	DT
cord-259347-3acsko74	21	7	only	only	JJ
cord-259347-3acsko74	21	8	way	way	NN
cord-259347-3acsko74	22	1	hCoVs	hCoVs	NNP
cord-259347-3acsko74	22	2	were	be	VBD
cord-259347-3acsko74	22	3	related	relate	VBN
cord-259347-3acsko74	22	4	to	to	IN
cord-259347-3acsko74	22	5	central	central	JJ
cord-259347-3acsko74	22	6	nervous	nervous	JJ
cord-259347-3acsko74	22	7	system	system	NN
cord-259347-3acsko74	22	8	.	.	.
cord-259347-3acsko74	23	1	In	in	IN
cord-259347-3acsko74	23	2	fact	fact	NN
cord-259347-3acsko74	23	3	,	,	,
cord-259347-3acsko74	23	4	hCoVs	hCoVs	NNP
cord-259347-3acsko74	23	5	have	have	VBP
cord-259347-3acsko74	23	6	also	also	RB
cord-259347-3acsko74	23	7	been	be	VBN
cord-259347-3acsko74	23	8	shown	show	VBN
cord-259347-3acsko74	23	9	to	to	TO
cord-259347-3acsko74	23	10	be	be	VB
cord-259347-3acsko74	23	11	capable	capable	JJ
cord-259347-3acsko74	23	12	of	of	IN
cord-259347-3acsko74	23	13	invading	invade	VBG
cord-259347-3acsko74	23	14	neural	neural	JJ
cord-259347-3acsko74	23	15	cells	cell	NNS
cord-259347-3acsko74	23	16	,	,	,
cord-259347-3acsko74	23	17	and	and	CC
cord-259347-3acsko74	23	18	hence	hence	RB
cord-259347-3acsko74	23	19	manifesting	manifest	VBG
cord-259347-3acsko74	23	20	with	with	IN
cord-259347-3acsko74	23	21	neurological	neurological	JJ
cord-259347-3acsko74	23	22	symptoms	symptom	NNS
cord-259347-3acsko74	23	23	and	and	CC
cord-259347-3acsko74	23	24	signs	sign	NNS
cord-259347-3acsko74	23	25	(	(	-LRB-
cord-259347-3acsko74	23	26	Table	table	NN
cord-259347-3acsko74	23	27	1	1	CD
cord-259347-3acsko74	23	28	)	)	-RRB-
cord-259347-3acsko74	23	29	.	.	.
cord-259347-3acsko74	24	1	The	the	DT
cord-259347-3acsko74	24	2	potential	potential	NN
cord-259347-3acsko74	24	3	for	for	IN
cord-259347-3acsko74	24	4	significant	significant	JJ
cord-259347-3acsko74	24	5	neurological	neurological	JJ
cord-259347-3acsko74	24	6	deficits	deficit	NNS
cord-259347-3acsko74	24	7	recently	recently	RB
cord-259347-3acsko74	24	8	became	become	VBD
cord-259347-3acsko74	24	9	a	a	DT
cord-259347-3acsko74	24	10	concern	concern	NN
cord-259347-3acsko74	24	11	following	follow	VBG
cord-259347-3acsko74	24	12	the	the	DT
cord-259347-3acsko74	24	13	report	report	NN
cord-259347-3acsko74	24	14	of	of	IN
cord-259347-3acsko74	24	15	a	a	DT
cord-259347-3acsko74	24	16	COVID-19	covid-19	JJ
cord-259347-3acsko74	24	17	patient	patient	NN
cord-259347-3acsko74	24	18	who	who	WP
cord-259347-3acsko74	24	19	demonstrated	demonstrate	VBD
cord-259347-3acsko74	24	20	loss	loss	NN
cord-259347-3acsko74	24	21	of	of	IN
cord-259347-3acsko74	24	22	involuntary	involuntary	JJ
cord-259347-3acsko74	24	23	control	control	NN
cord-259347-3acsko74	24	24	of	of	IN
cord-259347-3acsko74	24	25	breathing	breathing	NN
cord-259347-3acsko74	24	26	due	due	IN
cord-259347-3acsko74	24	27	to	to	IN
cord-259347-3acsko74	24	28	presumed	presume	VBN
cord-259347-3acsko74	24	29	involvement	involvement	NN
cord-259347-3acsko74	24	30	of	of	IN
cord-259347-3acsko74	24	31	the	the	DT
cord-259347-3acsko74	24	32	inspiratory	inspiratory	JJ
cord-259347-3acsko74	24	33	area	area	NN
cord-259347-3acsko74	24	34	in	in	IN
cord-259347-3acsko74	24	35	the	the	DT
cord-259347-3acsko74	24	36	brainstem	brainstem	NN
cord-259347-3acsko74	24	37	,	,	,
cord-259347-3acsko74	24	38	as	as	RB
cord-259347-3acsko74	24	39	well	well	RB
cord-259347-3acsko74	24	40	as	as	IN
cord-259347-3acsko74	24	41	reports	report	NNS
cord-259347-3acsko74	24	42	of	of	IN
cord-259347-3acsko74	24	43	SARS	SARS	NNP
cord-259347-3acsko74	24	44	-	-	HYPH
cord-259347-3acsko74	24	45	CoV-2	CoV-2	NNP
cord-259347-3acsko74	24	46	infected	infect	VBN
cord-259347-3acsko74	24	47	patients	patient	NNS
cord-259347-3acsko74	24	48	developing	develop	VBG
cord-259347-3acsko74	24	49	ataxia	ataxia	NN
cord-259347-3acsko74	24	50	,	,	,
cord-259347-3acsko74	24	51	loss	loss	NN
cord-259347-3acsko74	24	52	of	of	IN
cord-259347-3acsko74	24	53	smell	smell	NN
cord-259347-3acsko74	24	54	and	and	CC
cord-259347-3acsko74	24	55	convulsions	convulsion	NNS
cord-259347-3acsko74	24	56	[	[	-LRB-
cord-259347-3acsko74	24	57	7	7	CD
cord-259347-3acsko74	24	58	]	]	-RRB-
cord-259347-3acsko74	24	59	.	.	.
cord-259347-3acsko74	25	1	In	in	IN
cord-259347-3acsko74	25	2	vitro	vitro	FW
cord-259347-3acsko74	25	3	studies	study	NNS
cord-259347-3acsko74	25	4	have	have	VBP
cord-259347-3acsko74	25	5	shown	show	VBN
cord-259347-3acsko74	25	6	that	that	IN
cord-259347-3acsko74	25	7	229E	229e	CD
cord-259347-3acsko74	25	8	and	and	CC
cord-259347-3acsko74	25	9	OC43	OC43	NNP
cord-259347-3acsko74	25	10	hCoV	hcov	NN
cord-259347-3acsko74	25	11	strains	strain	NNS
cord-259347-3acsko74	25	12	can	can	MD
cord-259347-3acsko74	25	13	infect	infect	VB
cord-259347-3acsko74	25	14	a	a	DT
cord-259347-3acsko74	25	15	wide	wide	JJ
cord-259347-3acsko74	25	16	range	range	NN
cord-259347-3acsko74	25	17	of	of	IN
cord-259347-3acsko74	25	18	human	human	JJ
cord-259347-3acsko74	25	19	neural	neural	JJ
cord-259347-3acsko74	25	20	cell	cell	NN
cord-259347-3acsko74	25	21	cultures	culture	NNS
cord-259347-3acsko74	25	22	,	,	,
cord-259347-3acsko74	25	23	including	include	VBG
cord-259347-3acsko74	25	24	neuroblastoma	neuroblastoma	NN
cord-259347-3acsko74	25	25	,	,	,
cord-259347-3acsko74	25	26	neuroglioma	neuroglioma	NNP
cord-259347-3acsko74	25	27	,	,	,
cord-259347-3acsko74	25	28	astrocytoma	astrocytoma	NN
cord-259347-3acsko74	25	29	,	,	,
cord-259347-3acsko74	25	30	microglial	microglial	JJ
cord-259347-3acsko74	25	31	and	and	CC
cord-259347-3acsko74	25	32	oligodendrocytic	oligodendrocytic	JJ
cord-259347-3acsko74	25	33	cell	cell	NN
cord-259347-3acsko74	25	34	lines	line	NNS
cord-259347-3acsko74	25	35	[	[	-LRB-
cord-259347-3acsko74	25	36	8À10	8à10	CD
cord-259347-3acsko74	25	37	]	]	-RRB-
cord-259347-3acsko74	25	38	.	.	.
cord-259347-3acsko74	26	1	In	in	IN
cord-259347-3acsko74	26	2	addition	addition	NN
cord-259347-3acsko74	26	3	,	,	,
cord-259347-3acsko74	26	4	animal	animal	NN
cord-259347-3acsko74	26	5	studies	study	NNS
cord-259347-3acsko74	26	6	have	have	VBP
cord-259347-3acsko74	26	7	also	also	RB
cord-259347-3acsko74	26	8	revealed	reveal	VBN
cord-259347-3acsko74	26	9	the	the	DT
cord-259347-3acsko74	26	10	neuroinvasion	neuroinvasion	NN
cord-259347-3acsko74	26	11	and	and	CC
cord-259347-3acsko74	26	12	neurovirulence	neurovirulence	NN
cord-259347-3acsko74	26	13	of	of	IN
cord-259347-3acsko74	26	14	hCoV	hCoV	NNP
cord-259347-3acsko74	26	15	-	-	HYPH
cord-259347-3acsko74	26	16	OC43	OC43	NNP
cord-259347-3acsko74	26	17	[	[	-LRB-
cord-259347-3acsko74	26	18	4,5,11À13	4,5,11à13	CD
cord-259347-3acsko74	26	19	]	]	-RRB-
cord-259347-3acsko74	26	20	.	.	.
cord-259347-3acsko74	27	1	Importantly	importantly	RB
cord-259347-3acsko74	27	2	,	,	,
cord-259347-3acsko74	27	3	a	a	DT
cord-259347-3acsko74	27	4	significantly	significantly	RB
cord-259347-3acsko74	27	5	higher	high	JJR
cord-259347-3acsko74	27	6	prevalence	prevalence	NN
cord-259347-3acsko74	27	7	of	of	IN
cord-259347-3acsko74	27	8	the	the	DT
cord-259347-3acsko74	27	9	OC43	OC43	NNP
cord-259347-3acsko74	27	10	strain	strain	NN
cord-259347-3acsko74	27	11	in	in	IN
cord-259347-3acsko74	27	12	terms	term	NNS
cord-259347-3acsko74	27	13	of	of	IN
cord-259347-3acsko74	27	14	viral	viral	JJ
cord-259347-3acsko74	27	15	RNA	RNA	NNP
cord-259347-3acsko74	27	16	detection	detection	NN
cord-259347-3acsko74	27	17	has	have	VBZ
cord-259347-3acsko74	27	18	been	be	VBN
cord-259347-3acsko74	27	19	shown	show	VBN
cord-259347-3acsko74	27	20	in	in	IN
cord-259347-3acsko74	27	21	human	human	JJ
cord-259347-3acsko74	27	22	brain	brain	NN
cord-259347-3acsko74	27	23	autopsy	autopsy	JJ
cord-259347-3acsko74	27	24	samples	sample	NNS
cord-259347-3acsko74	27	25	from	from	IN
cord-259347-3acsko74	27	26	multiple	multiple	JJ
cord-259347-3acsko74	27	27	sclerosis	sclerosis	NN
cord-259347-3acsko74	27	28	(	(	-LRB-
cord-259347-3acsko74	27	29	MS	MS	NNP
cord-259347-3acsko74	27	30	)	)	-RRB-
cord-259347-3acsko74	27	31	patients	patient	NNS
cord-259347-3acsko74	27	32	when	when	WRB
cord-259347-3acsko74	27	33	compared	compare	VBN
cord-259347-3acsko74	27	34	to	to	IN
cord-259347-3acsko74	27	35	other	other	JJ
cord-259347-3acsko74	27	36	neurological	neurological	JJ
cord-259347-3acsko74	27	37	diseases	disease	NNS
cord-259347-3acsko74	27	38	and	and	CC
cord-259347-3acsko74	27	39	normal	normal	JJ
cord-259347-3acsko74	27	40	controls	control	NNS
cord-259347-3acsko74	27	41	,	,	,
cord-259347-3acsko74	27	42	which	which	WDT
cord-259347-3acsko74	27	43	is	be	VBZ
cord-259347-3acsko74	27	44	consistent	consistent	JJ
cord-259347-3acsko74	27	45	with	with	IN
cord-259347-3acsko74	27	46	the	the	DT
cord-259347-3acsko74	27	47	left	left	JJ
cord-259347-3acsko74	27	48	lower	low	JJR
cord-259347-3acsko74	27	49	lobe	lobe	NN
cord-259347-3acsko74	27	50	infiltrates	infiltrate	VBZ
cord-259347-3acsko74	27	51	(	(	-LRB-
cord-259347-3acsko74	27	52	11	11	CD
cord-259347-3acsko74	27	53	)	)	-RRB-
cord-259347-3acsko74	27	54	→obvious	→obvious	JJ
cord-259347-3acsko74	27	55	resolution	resolution	NN
cord-259347-3acsko74	27	56	(	(	-LRB-
cord-259347-3acsko74	27	57	28	28	CD
cord-259347-3acsko74	27	58	)	)	-RRB-
cord-259347-3acsko74	27	59	→progressive	→progressive	CD
cord-259347-3acsko74	27	60	bibasilar	bibasilar	JJ
cord-259347-3acsko74	27	61	infiltrations	infiltration	NNS
cord-259347-3acsko74	27	62	(	(	-LRB-
cord-259347-3acsko74	27	63	35	35	CD
cord-259347-3acsko74	27	64	)	)	-RRB-
cord-259347-3acsko74	27	65	CT	CT	NNP
cord-259347-3acsko74	27	66	:	:	:
cord-259347-3acsko74	27	67	broad	broad	JJ
cord-259347-3acsko74	27	68	encephalic	encephalic	JJ
cord-259347-3acsko74	27	69	pathological	pathological	JJ
cord-259347-3acsko74	27	70	changes	change	NNS
cord-259347-3acsko74	27	71	of	of	IN
cord-259347-3acsko74	27	72	probably	probably	RB
cord-259347-3acsko74	27	73	ischemia	ischemia	NN
cord-259347-3acsko74	27	74	and	and	CC
cord-259347-3acsko74	27	75	necrosis	necrosis	NN
cord-259347-3acsko74	27	76	and	and	CC
cord-259347-3acsko74	27	77	brain	brain	NN
cord-259347-3acsko74	27	78	edema	edema	NN
cord-259347-3acsko74	27	79	(	(	-LRB-
cord-259347-3acsko74	27	80	33	33	CD
cord-259347-3acsko74	27	81	)	)	-RRB-
cord-259347-3acsko74	28	1	none	none	NNP
cord-259347-3acsko74	28	2	Eye	eye	JJ
cord-259347-3acsko74	28	3	-	-	HYPH
cord-259347-3acsko74	28	4	ground	ground	NN
cord-259347-3acsko74	28	5	exam	exam	NN
cord-259347-3acsko74	28	6	:	:	:
cord-259347-3acsko74	28	7	an	an	DT
cord-259347-3acsko74	28	8	exudation	exudation	NN
cord-259347-3acsko74	28	9	around	around	IN
cord-259347-3acsko74	28	10	the	the	DT
cord-259347-3acsko74	28	11	visual	visual	JJ
cord-259347-3acsko74	28	12	yellow	yellow	JJ
cord-259347-3acsko74	28	13	zone	zone	NN
cord-259347-3acsko74	28	14	(	(	-LRB-
cord-259347-3acsko74	28	15	26	26	CD
cord-259347-3acsko74	28	16	)	)	-RRB-
cord-259347-3acsko74	28	17	Death	death	NN
cord-259347-3acsko74	28	18	(	(	-LRB-
cord-259347-3acsko74	28	19	Recovery	Recovery	NNP
cord-259347-3acsko74	28	20	[	[	-LRB-
cord-259347-3acsko74	28	21	15	15	CD
cord-259347-3acsko74	28	22	]	]	-RRB-
cord-259347-3acsko74	29	1	All	all	DT
cord-259347-3acsko74	29	2	cases	case	NNS
cord-259347-3acsko74	29	3	had	have	VBD
cord-259347-3acsko74	29	4	fever	fever	NN
cord-259347-3acsko74	29	5	and/or	and/or	CC
cord-259347-3acsko74	29	6	flu	flu	NN
cord-259347-3acsko74	29	7	-	-	HYPH
cord-259347-3acsko74	29	8	like	like	JJ
cord-259347-3acsko74	29	9	symptoms	symptom	NNS
cord-259347-3acsko74	29	10	at	at	IN
cord-259347-3acsko74	29	11	the	the	DT
cord-259347-3acsko74	29	12	onset	onset	NN
cord-259347-3acsko74	29	13	.	.	.
cord-259347-3acsko74	30	1	Half	half	NN
cord-259347-3acsko74	30	2	of	of	IN
cord-259347-3acsko74	30	3	the	the	DT
cord-259347-3acsko74	30	4	patients	patient	NNS
cord-259347-3acsko74	30	5	(	(	-LRB-
cord-259347-3acsko74	30	6	5/10	5/10	CD
cord-259347-3acsko74	30	7	)	)	-RRB-
cord-259347-3acsko74	30	8	had	have	VBD
cord-259347-3acsko74	30	9	headache	headache	NN
cord-259347-3acsko74	30	10	,	,	,
cord-259347-3acsko74	30	11	dizziness	dizziness	NN
cord-259347-3acsko74	30	12	or	or	CC
cord-259347-3acsko74	30	13	vomiting	vomiting	NN
cord-259347-3acsko74	30	14	as	as	IN
cord-259347-3acsko74	30	15	an	an	DT
cord-259347-3acsko74	30	16	early	early	JJ
cord-259347-3acsko74	30	17	sign	sign	NN
cord-259347-3acsko74	30	18	of	of	IN
cord-259347-3acsko74	30	19	neurological	neurological	JJ
cord-259347-3acsko74	30	20	manifestation	manifestation	NN
cord-259347-3acsko74	30	21	.	.	.
cord-259347-3acsko74	31	1	2/3	2/3	CD
cord-259347-3acsko74	31	2	SARS	SARS	NNP
cord-259347-3acsko74	31	3	patients	patient	NNS
cord-259347-3acsko74	31	4	had	have	VBD
cord-259347-3acsko74	31	5	seizures	seizure	NNS
cord-259347-3acsko74	31	6	,	,	,
cord-259347-3acsko74	31	7	whereas	whereas	IN
cord-259347-3acsko74	31	8	3/5	3/5	CD
cord-259347-3acsko74	31	9	MERS	MERS	NNP
cord-259347-3acsko74	31	10	patients	patient	NNS
cord-259347-3acsko74	31	11	and	and	CC
cord-259347-3acsko74	31	12	both	both	CC
cord-259347-3acsko74	31	13	OC43-infected	oc43-infected	CD
cord-259347-3acsko74	31	14	cases	case	NNS
cord-259347-3acsko74	31	15	had	have	VBD
cord-259347-3acsko74	31	16	facial	facial	JJ
cord-259347-3acsko74	31	17	/	/	SYM
cord-259347-3acsko74	31	18	limb	limb	NN
cord-259347-3acsko74	31	19	paralysis	paralysis	NN
cord-259347-3acsko74	31	20	.	.	.
cord-259347-3acsko74	32	1	Unfortunately	unfortunately	RB
cord-259347-3acsko74	32	2	,	,	,
cord-259347-3acsko74	32	3	MERS	MERS	NNP
cord-259347-3acsko74	32	4	-	-	HYPH
cord-259347-3acsko74	32	5	CoV	CoV	NNP
cord-259347-3acsko74	32	6	has	have	VBZ
cord-259347-3acsko74	32	7	not	not	RB
cord-259347-3acsko74	32	8	been	be	VBN
cord-259347-3acsko74	32	9	detected	detect	VBN
cord-259347-3acsko74	32	10	in	in	IN
cord-259347-3acsko74	32	11	CSF	CSF	NNP
cord-259347-3acsko74	32	12	samples	sample	NNS
cord-259347-3acsko74	32	13	of	of	IN
cord-259347-3acsko74	32	14	any	any	DT
cord-259347-3acsko74	32	15	of	of	IN
cord-259347-3acsko74	32	16	the	the	DT
cord-259347-3acsko74	32	17	reported	report	VBN
cord-259347-3acsko74	32	18	cases	case	NNS
cord-259347-3acsko74	32	19	.	.	.
cord-259347-3acsko74	33	1	Ischaemic	Ischaemic	NNP
cord-259347-3acsko74	33	2	changes	change	NNS
cord-259347-3acsko74	33	3	have	have	VBP
cord-259347-3acsko74	33	4	been	be	VBN
cord-259347-3acsko74	33	5	detected	detect	VBN
cord-259347-3acsko74	33	6	in	in	IN
cord-259347-3acsko74	33	7	images	image	NNS
cord-259347-3acsko74	33	8	of	of	IN
cord-259347-3acsko74	33	9	half	half	NN
cord-259347-3acsko74	33	10	of	of	IN
cord-259347-3acsko74	33	11	the	the	DT
cord-259347-3acsko74	33	12	patients	patient	NNS
cord-259347-3acsko74	33	13	,	,	,
cord-259347-3acsko74	33	14	while	while	IN
cord-259347-3acsko74	33	15	haemorrhagic	haemorrhagic	JJ
cord-259347-3acsko74	33	16	pathology	pathology	NN
cord-259347-3acsko74	33	17	has	have	VBZ
cord-259347-3acsko74	33	18	been	be	VBN
cord-259347-3acsko74	33	19	identified	identify	VBN
cord-259347-3acsko74	33	20	on	on	IN
cord-259347-3acsko74	33	21	one	one	CD
cord-259347-3acsko74	33	22	MERS	MERS	NNP
cord-259347-3acsko74	33	23	patient	patient	JJ
cord-259347-3acsko74	33	24	.	.	.
cord-259347-3acsko74	34	1	The	the	DT
cord-259347-3acsko74	34	2	OC43-related	oc43-related	CD
cord-259347-3acsko74	34	3	CNS	CNS	NNP
cord-259347-3acsko74	34	4	-	-	HYPH
cord-259347-3acsko74	34	5	infected	infect	VBN
cord-259347-3acsko74	34	6	patients	patient	NNS
cord-259347-3acsko74	34	7	were	be	VBD
cord-259347-3acsko74	34	8	younger	young	JJR
cord-259347-3acsko74	34	9	compared	compare	VBN
cord-259347-3acsko74	34	10	to	to	IN
cord-259347-3acsko74	34	11	SARS	SARS	NNP
cord-259347-3acsko74	34	12	and	and	CC
cord-259347-3acsko74	34	13	MERS	MERS	NNP
cord-259347-3acsko74	34	14	patients	patient	NNS
cord-259347-3acsko74	34	15	.	.	.
cord-259347-3acsko74	35	1	GCS	GCS	NNP
cord-259347-3acsko74	35	2	:	:	:
cord-259347-3acsko74	36	1	Glasgow	Glasgow	NNP
cord-259347-3acsko74	36	2	Coma	Coma	NNP
cord-259347-3acsko74	36	3	Scale	Scale	NNP
cord-259347-3acsko74	36	4	;	;	:
cord-259347-3acsko74	36	5	NCV	ncv	NN
cord-259347-3acsko74	36	6	:	:	:
cord-259347-3acsko74	36	7	Nerve	nerve	NN
cord-259347-3acsko74	36	8	Conduct	conduct	NN
cord-259347-3acsko74	36	9	Velocity	velocity	NN
cord-259347-3acsko74	36	10	;	;	:
cord-259347-3acsko74	36	11	EMG	EMG	NNP
cord-259347-3acsko74	36	12	:	:	:
cord-259347-3acsko74	36	13	Electroneuromyography	Electroneuromyography	NNP
cord-259347-3acsko74	36	14	.	.	.
cord-259347-3acsko74	37	1	capability	capability	NN
cord-259347-3acsko74	37	2	for	for	IN
cord-259347-3acsko74	37	3	neuroinvasion	neuroinvasion	NN
cord-259347-3acsko74	37	4	of	of	IN
cord-259347-3acsko74	37	5	this	this	DT
cord-259347-3acsko74	37	6	hCoV	hcov	NN
cord-259347-3acsko74	37	7	[	[	-LRB-
cord-259347-3acsko74	37	8	3	3	CD
cord-259347-3acsko74	37	9	]	]	-RRB-
cord-259347-3acsko74	37	10	.	.	.
cord-259347-3acsko74	38	1	Furthermore	furthermore	RB
cord-259347-3acsko74	38	2	,	,	,
cord-259347-3acsko74	38	3	OC43	OC43	NNP
cord-259347-3acsko74	38	4	has	have	VBZ
cord-259347-3acsko74	38	5	also	also	RB
cord-259347-3acsko74	38	6	been	be	VBN
cord-259347-3acsko74	38	7	identified	identify	VBN
cord-259347-3acsko74	38	8	in	in	IN
cord-259347-3acsko74	38	9	a	a	DT
cord-259347-3acsko74	38	10	teenager	teenager	NN
cord-259347-3acsko74	38	11	patient	patient	NN
cord-259347-3acsko74	38	12	with	with	IN
cord-259347-3acsko74	38	13	demyelinating	demyelinating	JJ
cord-259347-3acsko74	38	14	disease	disease	NN
cord-259347-3acsko74	38	15	,	,	,
cord-259347-3acsko74	38	16	in	in	IN
cord-259347-3acsko74	38	17	whom	whom	WP
cord-259347-3acsko74	38	18	the	the	DT
cord-259347-3acsko74	38	19	virus	virus	NN
cord-259347-3acsko74	38	20	was	be	VBD
cord-259347-3acsko74	38	21	detected	detect	VBN
cord-259347-3acsko74	38	22	in	in	IN
cord-259347-3acsko74	38	23	both	both	DT
cord-259347-3acsko74	38	24	CSF	CSF	NNP
cord-259347-3acsko74	38	25	and	and	CC
cord-259347-3acsko74	38	26	nasopharyngeal	nasopharyngeal	JJ
cord-259347-3acsko74	38	27	secretions	secretion	NNS
cord-259347-3acsko74	38	28	by	by	IN
cord-259347-3acsko74	38	29	PCR	PCR	NNP
cord-259347-3acsko74	38	30	technology	technology	NN
cord-259347-3acsko74	38	31	[	[	-LRB-
cord-259347-3acsko74	38	32	14	14	CD
cord-259347-3acsko74	38	33	]	]	-RRB-
cord-259347-3acsko74	38	34	.	.	.
cord-259347-3acsko74	39	1	The	the	DT
cord-259347-3acsko74	39	2	hCoV	hCoV	NNP
cord-259347-3acsko74	39	3	-	-	HYPH
cord-259347-3acsko74	39	4	OC43	OC43	NNP
cord-259347-3acsko74	39	5	has	have	VBZ
cord-259347-3acsko74	39	6	also	also	RB
cord-259347-3acsko74	39	7	been	be	VBN
cord-259347-3acsko74	39	8	associated	associate	VBN
cord-259347-3acsko74	39	9	with	with	IN
cord-259347-3acsko74	39	10	a	a	DT
cord-259347-3acsko74	39	11	fatal	fatal	JJ
cord-259347-3acsko74	39	12	encephalitis	encephalitis	NN
cord-259347-3acsko74	39	13	in	in	IN
cord-259347-3acsko74	39	14	an	an	DT
cord-259347-3acsko74	39	15	infant	infant	NN
cord-259347-3acsko74	39	16	although	although	IN
cord-259347-3acsko74	39	17	the	the	DT
cord-259347-3acsko74	39	18	underlying	underlie	VBG
cord-259347-3acsko74	39	19	circumstances	circumstance	NNS
cord-259347-3acsko74	39	20	are	be	VBP
cord-259347-3acsko74	39	21	still	still	RB
cord-259347-3acsko74	39	22	unclear	unclear	JJ
cord-259347-3acsko74	39	23	[	[	-LRB-
cord-259347-3acsko74	39	24	15	15	CD
cord-259347-3acsko74	39	25	]	]	-RRB-
cord-259347-3acsko74	39	26	.	.	.
cord-259347-3acsko74	40	1	Additionally	additionally	RB
cord-259347-3acsko74	40	2	,	,	,
cord-259347-3acsko74	40	3	co	co	NN
cord-259347-3acsko74	40	4	-	-	NN
cord-259347-3acsko74	40	5	infection	infection	NN
cord-259347-3acsko74	40	6	with	with	IN
cord-259347-3acsko74	40	7	the	the	DT
cord-259347-3acsko74	40	8	229E	229e	CD
cord-259347-3acsko74	40	9	and	and	CC
cord-259347-3acsko74	40	10	OC43	OC43	NNP
cord-259347-3acsko74	40	11	strains	strain	NNS
cord-259347-3acsko74	40	12	has	have	VBZ
cord-259347-3acsko74	40	13	been	be	VBN
cord-259347-3acsko74	40	14	reported	report	VBN
cord-259347-3acsko74	40	15	in	in	IN
cord-259347-3acsko74	40	16	a	a	DT
cord-259347-3acsko74	40	17	young	young	JJ
cord-259347-3acsko74	40	18	girl	girl	NN
cord-259347-3acsko74	40	19	who	who	WP
cord-259347-3acsko74	40	20	developed	develop	VBD
cord-259347-3acsko74	40	21	an	an	DT
cord-259347-3acsko74	40	22	acute	acute	JJ
cord-259347-3acsko74	40	23	flaccid	flaccid	JJ
cord-259347-3acsko74	40	24	paralysis	paralysis	NN
cord-259347-3acsko74	40	25	[	[	-LRB-
cord-259347-3acsko74	40	26	16	16	CD
cord-259347-3acsko74	40	27	]	]	-RRB-
cord-259347-3acsko74	40	28	.	.	.
cord-259347-3acsko74	41	1	SARS	SARS	NNP
cord-259347-3acsko74	41	2	-	-	HYPH
cord-259347-3acsko74	41	3	CoV	CoV	NNP
cord-259347-3acsko74	41	4	and	and	CC
cord-259347-3acsko74	41	5	MERS	MERS	NNP
cord-259347-3acsko74	41	6	-	-	HYPH
cord-259347-3acsko74	41	7	CoV	CoV	NNP
cord-259347-3acsko74	41	8	have	have	VBP
cord-259347-3acsko74	41	9	also	also	RB
cord-259347-3acsko74	41	10	been	be	VBN
cord-259347-3acsko74	41	11	linked	link	VBN
cord-259347-3acsko74	41	12	with	with	IN
cord-259347-3acsko74	41	13	neurological	neurological	JJ
cord-259347-3acsko74	41	14	manifestations	manifestation	NNS
cord-259347-3acsko74	41	15	.	.	.
cord-259347-3acsko74	42	1	SARS	SARS	NNP
cord-259347-3acsko74	42	2	-	-	HYPH
cord-259347-3acsko74	42	3	CoV	CoV	NNP
cord-259347-3acsko74	42	4	has	have	VBZ
cord-259347-3acsko74	42	5	been	be	VBN
cord-259347-3acsko74	42	6	shown	show	VBN
cord-259347-3acsko74	42	7	to	to	TO
cord-259347-3acsko74	42	8	be	be	VB
cord-259347-3acsko74	42	9	capable	capable	JJ
cord-259347-3acsko74	42	10	of	of	IN
cord-259347-3acsko74	42	11	infecting	infect	VBG
cord-259347-3acsko74	42	12	human	human	JJ
cord-259347-3acsko74	42	13	neural	neural	JJ
cord-259347-3acsko74	42	14	cells	cell	NNS
cord-259347-3acsko74	42	15	[	[	-LRB-
cord-259347-3acsko74	42	16	17	17	CD
cord-259347-3acsko74	42	17	]	]	-RRB-
cord-259347-3acsko74	42	18	,	,	,
cord-259347-3acsko74	42	19	and	and	CC
cord-259347-3acsko74	42	20	neuroinvasion	neuroinvasion	NN
cord-259347-3acsko74	42	21	and	and	CC
cord-259347-3acsko74	42	22	neurovirulence	neurovirulence	NNP
cord-259347-3acsko74	42	23	have	have	VBP
cord-259347-3acsko74	42	24	been	be	VBN
cord-259347-3acsko74	42	25	found	find	VBN
cord-259347-3acsko74	42	26	in	in	IN
cord-259347-3acsko74	42	27	studies	study	NNS
cord-259347-3acsko74	42	28	involving	involve	VBG
cord-259347-3acsko74	42	29	both	both	DT
cord-259347-3acsko74	42	30	SARS	SARS	NNP
cord-259347-3acsko74	42	31	-	-	HYPH
cord-259347-3acsko74	42	32	CoV	CoV	NNP
cord-259347-3acsko74	42	33	[	[	-LRB-
cord-259347-3acsko74	42	34	18À23	18à23	CD
cord-259347-3acsko74	42	35	]	]	-RRB-
cord-259347-3acsko74	42	36	and	and	CC
cord-259347-3acsko74	42	37	MERS	MERS	NNP
cord-259347-3acsko74	42	38	-	-	HYPH
cord-259347-3acsko74	42	39	CoV	CoV	NNP
cord-259347-3acsko74	42	40	[	[	-LRB-
cord-259347-3acsko74	42	41	24	24	CD
cord-259347-3acsko74	42	42	,	,	,
cord-259347-3acsko74	42	43	25	25	CD
cord-259347-3acsko74	42	44	]	]	-RRB-
cord-259347-3acsko74	42	45	.	.	.
cord-259347-3acsko74	43	1	An	an	DT
cord-259347-3acsko74	43	2	association	association	NN
cord-259347-3acsko74	43	3	of	of	IN
cord-259347-3acsko74	43	4	these	these	DT
cord-259347-3acsko74	43	5	two	two	CD
cord-259347-3acsko74	43	6	more	more	JJR
cord-259347-3acsko74	43	7	highly	highly	RB
cord-259347-3acsko74	43	8	pathogenic	pathogenic	JJ
cord-259347-3acsko74	43	9	viruses	virus	NNS
cord-259347-3acsko74	43	10	with	with	IN
cord-259347-3acsko74	43	11	neurological	neurological	JJ
cord-259347-3acsko74	43	12	manifestations	manifestation	NNS
cord-259347-3acsko74	43	13	have	have	VBP
cord-259347-3acsko74	43	14	also	also	RB
cord-259347-3acsko74	43	15	been	be	VBN
cord-259347-3acsko74	43	16	reported	report	VBN
cord-259347-3acsko74	43	17	.	.	.
cord-259347-3acsko74	44	1	For	for	IN
cord-259347-3acsko74	44	2	instance	instance	NN
cord-259347-3acsko74	44	3	,	,	,
cord-259347-3acsko74	44	4	SARS	SARS	NNP
cord-259347-3acsko74	44	5	-	-	HYPH
cord-259347-3acsko74	44	6	CoV	CoV	NNP
cord-259347-3acsko74	44	7	particles	particle	NNS
cord-259347-3acsko74	44	8	and	and	CC
cord-259347-3acsko74	44	9	genomic	genomic	JJ
cord-259347-3acsko74	44	10	sequences	sequence	NNS
cord-259347-3acsko74	44	11	have	have	VBP
cord-259347-3acsko74	44	12	been	be	VBN
cord-259347-3acsko74	44	13	detected	detect	VBN
cord-259347-3acsko74	44	14	from	from	IN
cord-259347-3acsko74	44	15	post	post	JJ
cord-259347-3acsko74	44	16	-	-	JJ
cord-259347-3acsko74	44	17	mortem	mortem	JJ
cord-259347-3acsko74	44	18	brain	brain	NN
cord-259347-3acsko74	44	19	tissues	tissue	NNS
cord-259347-3acsko74	44	20	of	of	IN
cord-259347-3acsko74	44	21	SARS	SARS	NNP
cord-259347-3acsko74	44	22	patients	patient	NNS
cord-259347-3acsko74	44	23	[	[	-LRB-
cord-259347-3acsko74	44	24	26À28	26à28	CD
cord-259347-3acsko74	44	25	]	]	-RRB-
cord-259347-3acsko74	44	26	.	.	.
cord-259347-3acsko74	45	1	They	-PRON-	PRP
cord-259347-3acsko74	45	2	have	have	VBP
cord-259347-3acsko74	45	3	also	also	RB
cord-259347-3acsko74	45	4	been	be	VBN
cord-259347-3acsko74	45	5	detected	detect	VBN
cord-259347-3acsko74	45	6	using	use	VBG
cord-259347-3acsko74	45	7	RT	RT	NNP
cord-259347-3acsko74	45	8	-	-	HYPH
cord-259347-3acsko74	45	9	PCR	PCR	NNP
cord-259347-3acsko74	45	10	in	in	IN
cord-259347-3acsko74	45	11	CSF	CSF	NNP
cord-259347-3acsko74	45	12	samples	sample	NNS
cord-259347-3acsko74	45	13	from	from	IN
cord-259347-3acsko74	45	14	a	a	DT
cord-259347-3acsko74	45	15	32-year	32-year	JJ
cord-259347-3acsko74	45	16	-	-	HYPH
cord-259347-3acsko74	45	17	old	old	JJ
cord-259347-3acsko74	45	18	pregnant	pregnant	JJ
cord-259347-3acsko74	45	19	female	female	JJ
cord-259347-3acsko74	45	20	patient	patient	NN
cord-259347-3acsko74	45	21	who	who	WP
cord-259347-3acsko74	45	22	presented	present	VBD
cord-259347-3acsko74	45	23	with	with	IN
cord-259347-3acsko74	45	24	a	a	DT
cord-259347-3acsko74	45	25	brief	brief	JJ
cord-259347-3acsko74	45	26	duration	duration	NN
cord-259347-3acsko74	45	27	generalized	generalize	VBN
cord-259347-3acsko74	45	28	convulsion	convulsion	NN
cord-259347-3acsko74	45	29	and	and	CC
cord-259347-3acsko74	45	30	accompanying	accompanying	JJ
cord-259347-3acsko74	45	31	loss	loss	NN
cord-259347-3acsko74	45	32	of	of	IN
cord-259347-3acsko74	45	33	consciousness	consciousness	NN
cord-259347-3acsko74	45	34	[	[	-LRB-
cord-259347-3acsko74	45	35	29	29	CD
cord-259347-3acsko74	45	36	]	]	-RRB-
cord-259347-3acsko74	45	37	and	and	CC
cord-259347-3acsko74	45	38	within	within	IN
cord-259347-3acsko74	45	39	24	24	CD
cord-259347-3acsko74	45	40	h	h	NN
cord-259347-3acsko74	45	41	of	of	IN
cord-259347-3acsko74	45	42	a	a	DT
cord-259347-3acsko74	45	43	first	first	JJ
cord-259347-3acsko74	45	44	seizure	seizure	NN
cord-259347-3acsko74	45	45	in	in	IN
cord-259347-3acsko74	45	46	a	a	DT
cord-259347-3acsko74	45	47	59-year	59-year	JJ
cord-259347-3acsko74	45	48	-	-	HYPH
cord-259347-3acsko74	45	49	old	old	JJ
cord-259347-3acsko74	45	50	female	female	JJ
cord-259347-3acsko74	45	51	patient	patient	NN
cord-259347-3acsko74	45	52	[	[	-LRB-
cord-259347-3acsko74	45	53	30	30	CD
cord-259347-3acsko74	45	54	]	]	-RRB-
cord-259347-3acsko74	45	55	.	.	.
cord-259347-3acsko74	46	1	Although	although	IN
cord-259347-3acsko74	46	2	there	there	EX
cord-259347-3acsko74	46	3	is	be	VBZ
cord-259347-3acsko74	46	4	less	less	JJR
cord-259347-3acsko74	46	5	of	of	IN
cord-259347-3acsko74	46	6	direct	direct	JJ
cord-259347-3acsko74	46	7	evidence	evidence	NN
cord-259347-3acsko74	46	8	of	of	IN
cord-259347-3acsko74	46	9	viral	viral	JJ
cord-259347-3acsko74	46	10	presence	presence	NN
cord-259347-3acsko74	46	11	in	in	IN
cord-259347-3acsko74	46	12	the	the	DT
cord-259347-3acsko74	46	13	CNS	CNS	NNP
cord-259347-3acsko74	46	14	,	,	,
cord-259347-3acsko74	46	15	MERS	MERS	NNP
cord-259347-3acsko74	46	16	patients	patient	NNS
cord-259347-3acsko74	46	17	have	have	VBP
cord-259347-3acsko74	46	18	also	also	RB
cord-259347-3acsko74	46	19	presented	present	VBN
cord-259347-3acsko74	46	20	with	with	IN
cord-259347-3acsko74	46	21	neurological	neurological	JJ
cord-259347-3acsko74	46	22	findings	finding	NNS
cord-259347-3acsko74	46	23	,	,	,
cord-259347-3acsko74	46	24	such	such	JJ
cord-259347-3acsko74	46	25	as	as	IN
cord-259347-3acsko74	46	26	altered	alter	VBN
cord-259347-3acsko74	46	27	consciousness	consciousness	NN
cord-259347-3acsko74	46	28	,	,	,
cord-259347-3acsko74	46	29	as	as	RB
cord-259347-3acsko74	46	30	well	well	RB
cord-259347-3acsko74	46	31	as	as	IN
cord-259347-3acsko74	46	32	manifested	manifest	VBN
cord-259347-3acsko74	46	33	with	with	IN
cord-259347-3acsko74	46	34	a	a	DT
cord-259347-3acsko74	46	35	wide	wide	JJ
cord-259347-3acsko74	46	36	range	range	NN
cord-259347-3acsko74	46	37	of	of	IN
cord-259347-3acsko74	46	38	abnormalities	abnormality	NNS
cord-259347-3acsko74	46	39	on	on	IN
cord-259347-3acsko74	46	40	brain	brain	NN
cord-259347-3acsko74	46	41	MRI	MRI	NNP
cord-259347-3acsko74	46	42	[	[	-LRB-
cord-259347-3acsko74	46	43	31	31	CD
cord-259347-3acsko74	46	44	,	,	,
cord-259347-3acsko74	46	45	32	32	CD
cord-259347-3acsko74	46	46	]	]	-RRB-
cord-259347-3acsko74	46	47	.	.	.
cord-259347-3acsko74	47	1	Regarding	regard	VBG
cord-259347-3acsko74	47	2	the	the	DT
cord-259347-3acsko74	47	3	regional	regional	JJ
cord-259347-3acsko74	47	4	distribution	distribution	NN
cord-259347-3acsko74	47	5	of	of	IN
cord-259347-3acsko74	47	6	the	the	DT
cord-259347-3acsko74	47	7	virus	virus	NN
cord-259347-3acsko74	47	8	in	in	IN
cord-259347-3acsko74	47	9	the	the	DT
cord-259347-3acsko74	47	10	CNS	CNS	NNP
cord-259347-3acsko74	47	11	,	,	,
cord-259347-3acsko74	47	12	data	datum	NNS
cord-259347-3acsko74	47	13	from	from	IN
cord-259347-3acsko74	47	14	the	the	DT
cord-259347-3acsko74	47	15	post	post	JJ
cord-259347-3acsko74	47	16	-	-	JJ
cord-259347-3acsko74	47	17	mortem	mortem	JJ
cord-259347-3acsko74	47	18	studies	study	NNS
cord-259347-3acsko74	47	19	have	have	VBP
cord-259347-3acsko74	47	20	shown	show	VBN
cord-259347-3acsko74	47	21	that	that	IN
cord-259347-3acsko74	47	22	infection	infection	NN
cord-259347-3acsko74	47	23	from	from	IN
cord-259347-3acsko74	47	24	SARS	SARS	NNP
cord-259347-3acsko74	47	25	-	-	HYPH
cord-259347-3acsko74	47	26	CoV	CoV	NNP
cord-259347-3acsko74	47	27	was	be	VBD
cord-259347-3acsko74	47	28	confined	confine	VBN
cord-259347-3acsko74	47	29	to	to	IN
cord-259347-3acsko74	47	30	neurons	neuron	NNS
cord-259347-3acsko74	47	31	within	within	IN
cord-259347-3acsko74	47	32	selected	select	VBN
cord-259347-3acsko74	47	33	areas	area	NNS
cord-259347-3acsko74	47	34	of	of	IN
cord-259347-3acsko74	47	35	the	the	DT
cord-259347-3acsko74	47	36	brain	brain	NN
cord-259347-3acsko74	47	37	,	,	,
cord-259347-3acsko74	47	38	including	include	VBG
cord-259347-3acsko74	47	39	thalamus	thalamus	NN
cord-259347-3acsko74	47	40	,	,	,
cord-259347-3acsko74	47	41	cerebrum	cerebrum	NN
cord-259347-3acsko74	47	42	,	,	,
cord-259347-3acsko74	47	43	brainstem	brainstem	NN
cord-259347-3acsko74	47	44	,	,	,
cord-259347-3acsko74	47	45	hypothalamus	hypothalamus	NN
cord-259347-3acsko74	47	46	and	and	CC
cord-259347-3acsko74	47	47	cortex	cortex	NNP
cord-259347-3acsko74	47	48	[	[	-LRB-
cord-259347-3acsko74	47	49	22	22	CD
cord-259347-3acsko74	47	50	,	,	,
cord-259347-3acsko74	47	51	27	27	CD
cord-259347-3acsko74	47	52	]	]	-RRB-
cord-259347-3acsko74	47	53	.	.	.
cord-259347-3acsko74	48	1	Intriguingly	intriguingly	RB
cord-259347-3acsko74	48	2	,	,	,
cord-259347-3acsko74	48	3	SARS	SARS	NNP
cord-259347-3acsko74	48	4	-	-	HYPH
cord-259347-3acsko74	48	5	CoV	CoV	NNP
cord-259347-3acsko74	48	6	has	have	VBZ
cord-259347-3acsko74	48	7	been	be	VBN
cord-259347-3acsko74	48	8	detected	detect	VBN
cord-259347-3acsko74	48	9	in	in	IN
cord-259347-3acsko74	48	10	cerebrum	cerebrum	NN
cord-259347-3acsko74	48	11	,	,	,
cord-259347-3acsko74	48	12	but	but	CC
cord-259347-3acsko74	48	13	not	not	RB
cord-259347-3acsko74	48	14	in	in	IN
cord-259347-3acsko74	48	15	cerebellum	cerebellum	NN
cord-259347-3acsko74	48	16	,	,	,
cord-259347-3acsko74	48	17	in	in	IN
cord-259347-3acsko74	48	18	both	both	DT
cord-259347-3acsko74	48	19	animal	animal	NN
cord-259347-3acsko74	48	20	[	[	-LRB-
cord-259347-3acsko74	48	21	22	22	CD
cord-259347-3acsko74	48	22	]	]	-RRB-
cord-259347-3acsko74	48	23	and	and	CC
cord-259347-3acsko74	48	24	human	human	JJ
cord-259347-3acsko74	48	25	[	[	-LRB-
cord-259347-3acsko74	48	26	28	28	CD
cord-259347-3acsko74	48	27	]	]	-RRB-
cord-259347-3acsko74	48	28	studies	study	NNS
cord-259347-3acsko74	48	29	.	.	.
cord-259347-3acsko74	49	1	In	in	IN
cord-259347-3acsko74	49	2	animals	animal	NNS
cord-259347-3acsko74	49	3	infected	infect	VBN
cord-259347-3acsko74	49	4	in	in	IN
cord-259347-3acsko74	49	5	the	the	DT
cord-259347-3acsko74	49	6	CNS	CNS	NNP
cord-259347-3acsko74	49	7	with	with	IN
cord-259347-3acsko74	49	8	MERS	MERS	NNP
cord-259347-3acsko74	49	9	-	-	HYPH
cord-259347-3acsko74	49	10	CoV	CoV	NNP
cord-259347-3acsko74	49	11	,	,	,
cord-259347-3acsko74	49	12	the	the	DT
cord-259347-3acsko74	49	13	thalamus	thalamus	NN
cord-259347-3acsko74	49	14	and	and	CC
cord-259347-3acsko74	49	15	brain	brain	NN
cord-259347-3acsko74	49	16	stem	stem	NN
cord-259347-3acsko74	49	17	were	be	VBD
cord-259347-3acsko74	49	18	found	find	VBN
cord-259347-3acsko74	49	19	to	to	TO
cord-259347-3acsko74	49	20	be	be	VB
cord-259347-3acsko74	49	21	the	the	DT
cord-259347-3acsko74	49	22	highest	high	JJS
cord-259347-3acsko74	49	23	infected	infected	JJ
cord-259347-3acsko74	49	24	sites	site	NNS
cord-259347-3acsko74	49	25	[	[	-LRB-
cord-259347-3acsko74	49	26	25	25	CD
cord-259347-3acsko74	49	27	]	]	-RRB-
cord-259347-3acsko74	49	28	.	.	.
cord-259347-3acsko74	50	1	Data	datum	NNS
cord-259347-3acsko74	50	2	from	from	IN
cord-259347-3acsko74	50	3	multiple	multiple	JJ
cord-259347-3acsko74	50	4	hACE2	hace2	NN
cord-259347-3acsko74	50	5	transgenic	transgenic	JJ
cord-259347-3acsko74	50	6	mouse	mouse	NN
cord-259347-3acsko74	50	7	models	model	NNS
cord-259347-3acsko74	50	8	has	have	VBZ
cord-259347-3acsko74	50	9	revealed	reveal	VBN
cord-259347-3acsko74	50	10	that	that	IN
cord-259347-3acsko74	50	11	SARS	SARS	NNP
cord-259347-3acsko74	50	12	-	-	HYPH
cord-259347-3acsko74	50	13	CoV	CoV	NNP
cord-259347-3acsko74	50	14	detection	detection	NN
cord-259347-3acsko74	50	15	in	in	IN
cord-259347-3acsko74	50	16	the	the	DT
cord-259347-3acsko74	50	17	brain	brain	NN
cord-259347-3acsko74	50	18	is	be	VBZ
cord-259347-3acsko74	50	19	significantly	significantly	RB
cord-259347-3acsko74	50	20	delayed	delay	VBN
cord-259347-3acsko74	50	21	compared	compare	VBN
cord-259347-3acsko74	50	22	to	to	IN
cord-259347-3acsko74	50	23	that	that	DT
cord-259347-3acsko74	50	24	within	within	IN
cord-259347-3acsko74	50	25	the	the	DT
cord-259347-3acsko74	50	26	lung	lung	NN
cord-259347-3acsko74	50	27	,	,	,
cord-259347-3acsko74	50	28	consistent	consistent	JJ
cord-259347-3acsko74	50	29	with	with	IN
cord-259347-3acsko74	50	30	the	the	DT
cord-259347-3acsko74	50	31	initial	initial	JJ
cord-259347-3acsko74	50	32	establishment	establishment	NN
cord-259347-3acsko74	50	33	of	of	IN
cord-259347-3acsko74	50	34	infection	infection	NN
cord-259347-3acsko74	50	35	within	within	IN
cord-259347-3acsko74	50	36	the	the	DT
cord-259347-3acsko74	50	37	respiratory	respiratory	JJ
cord-259347-3acsko74	50	38	system	system	NN
cord-259347-3acsko74	50	39	before	before	IN
cord-259347-3acsko74	50	40	dissemination	dissemination	NN
cord-259347-3acsko74	50	41	to	to	IN
cord-259347-3acsko74	50	42	the	the	DT
cord-259347-3acsko74	50	43	CNS	CNS	NNP
cord-259347-3acsko74	50	44	[	[	-LRB-
cord-259347-3acsko74	50	45	21À23	21à23	CD
cord-259347-3acsko74	50	46	]	]	-RRB-
cord-259347-3acsko74	50	47	.	.	.
cord-259347-3acsko74	51	1	Several	several	JJ
cord-259347-3acsko74	51	2	dissemination	dissemination	NN
cord-259347-3acsko74	51	3	routes	route	NNS
cord-259347-3acsko74	51	4	have	have	VBP
cord-259347-3acsko74	51	5	been	be	VBN
cord-259347-3acsko74	51	6	proposed	propose	VBN
cord-259347-3acsko74	51	7	for	for	IN
cord-259347-3acsko74	51	8	coronaviruses	coronaviruse	NNS
cord-259347-3acsko74	51	9	to	to	TO
cord-259347-3acsko74	51	10	gain	gain	VB
cord-259347-3acsko74	51	11	access	access	NN
cord-259347-3acsko74	51	12	to	to	IN
cord-259347-3acsko74	51	13	the	the	DT
cord-259347-3acsko74	51	14	CNS	CNS	NNP
cord-259347-3acsko74	51	15	(	(	-LRB-
cord-259347-3acsko74	51	16	Fig	fig	NN
cord-259347-3acsko74	51	17	.	.	.
cord-259347-3acsko74	51	18	1	1	CD
cord-259347-3acsko74	51	19	)	)	-RRB-
cord-259347-3acsko74	51	20	.	.	.
cord-259347-3acsko74	52	1	The	the	DT
cord-259347-3acsko74	52	2	mouse	mouse	NN
cord-259347-3acsko74	52	3	hepatitis	hepatitis	NN
cord-259347-3acsko74	52	4	virus	virus	NN
cord-259347-3acsko74	52	5	(	(	-LRB-
cord-259347-3acsko74	52	6	MHV	MHV	NNP
cord-259347-3acsko74	52	7	)	)	-RRB-
cord-259347-3acsko74	52	8	,	,	,
cord-259347-3acsko74	52	9	a	a	DT
cord-259347-3acsko74	52	10	neurotropic	neurotropic	NNP
cord-259347-3acsko74	52	11	coronavirus	coronavirus	NN
cord-259347-3acsko74	52	12	,	,	,
cord-259347-3acsko74	52	13	has	have	VBZ
cord-259347-3acsko74	52	14	been	be	VBN
cord-259347-3acsko74	52	15	shown	show	VBN
cord-259347-3acsko74	52	16	to	to	TO
cord-259347-3acsko74	52	17	enter	enter	VB
cord-259347-3acsko74	52	18	the	the	DT
cord-259347-3acsko74	52	19	CNS	CNS	NNP
cord-259347-3acsko74	52	20	via	via	IN
cord-259347-3acsko74	52	21	a	a	DT
cord-259347-3acsko74	52	22	transneuronal	transneuronal	JJ
cord-259347-3acsko74	52	23	route	route	NN
cord-259347-3acsko74	52	24	and	and	CC
cord-259347-3acsko74	52	25	disseminate	disseminate	VB
cord-259347-3acsko74	52	26	within	within	IN
cord-259347-3acsko74	52	27	the	the	DT
cord-259347-3acsko74	52	28	brain	brain	NN
cord-259347-3acsko74	52	29	via	via	IN
cord-259347-3acsko74	52	30	neuroanatomic	neuroanatomic	JJ
cord-259347-3acsko74	52	31	pathways	pathway	NNS
cord-259347-3acsko74	52	32	[	[	-LRB-
cord-259347-3acsko74	52	33	33	33	CD
cord-259347-3acsko74	52	34	]	]	-RRB-
cord-259347-3acsko74	52	35	.	.	.
cord-259347-3acsko74	53	1	In	in	IN
cord-259347-3acsko74	53	2	mice	mouse	NNS
cord-259347-3acsko74	53	3	transgenic	transgenic	JJ
cord-259347-3acsko74	53	4	for	for	IN
cord-259347-3acsko74	53	5	hACE2	hace2	ADD
cord-259347-3acsko74	53	6	,	,	,
cord-259347-3acsko74	53	7	SARS	SARS	NNP
cord-259347-3acsko74	53	8	-	-	HYPH
cord-259347-3acsko74	53	9	CoV	CoV	NNP
cord-259347-3acsko74	53	10	seems	seem	VBZ
cord-259347-3acsko74	53	11	to	to	TO
cord-259347-3acsko74	53	12	enter	enter	VB
cord-259347-3acsko74	53	13	the	the	DT
cord-259347-3acsko74	53	14	brain	brain	NN
cord-259347-3acsko74	53	15	via	via	IN
cord-259347-3acsko74	53	16	the	the	DT
cord-259347-3acsko74	53	17	olfactory	olfactory	JJ
cord-259347-3acsko74	53	18	bulb	bulb	NNP
cord-259347-3acsko74	53	19	post	post	NN
cord-259347-3acsko74	53	20	intranasal	intranasal	NN
cord-259347-3acsko74	53	21	inoculation	inoculation	NN
cord-259347-3acsko74	53	22	before	before	IN
cord-259347-3acsko74	53	23	disseminating	disseminate	VBG
cord-259347-3acsko74	53	24	transneuronally	transneuronally	RB
cord-259347-3acsko74	53	25	to	to	TO
cord-259347-3acsko74	53	26	distal	distal	VB
cord-259347-3acsko74	53	27	connected	connected	JJ
cord-259347-3acsko74	53	28	neurons	neuron	NNS
cord-259347-3acsko74	53	29	and	and	CC
cord-259347-3acsko74	53	30	causing	cause	VBG
cord-259347-3acsko74	53	31	the	the	DT
cord-259347-3acsko74	53	32	dysfunction/	dysfunction/	CD
cord-259347-3acsko74	53	33	death	death	NN
cord-259347-3acsko74	53	34	of	of	IN
cord-259347-3acsko74	53	35	these	these	DT
cord-259347-3acsko74	53	36	infected	infected	JJ
cord-259347-3acsko74	53	37	neurons	neuron	NNS
cord-259347-3acsko74	53	38	[	[	-LRB-
cord-259347-3acsko74	53	39	18	18	CD
cord-259347-3acsko74	53	40	]	]	-RRB-
cord-259347-3acsko74	53	41	.	.	.
cord-259347-3acsko74	54	1	A	a	DT
cord-259347-3acsko74	54	2	similar	similar	JJ
cord-259347-3acsko74	54	3	dissemination	dissemination	NN
cord-259347-3acsko74	54	4	pattern	pattern	NN
cord-259347-3acsko74	54	5	has	have	VBZ
cord-259347-3acsko74	54	6	also	also	RB
cord-259347-3acsko74	54	7	been	be	VBN
cord-259347-3acsko74	54	8	detected	detect	VBN
cord-259347-3acsko74	54	9	in	in	IN
cord-259347-3acsko74	54	10	OC43-inoculated	oc43-inoculated	CD
cord-259347-3acsko74	54	11	mice	mouse	NNS
cord-259347-3acsko74	54	12	[	[	-LRB-
cord-259347-3acsko74	54	13	5	5	CD
cord-259347-3acsko74	54	14	,	,	,
cord-259347-3acsko74	54	15	13	13	CD
cord-259347-3acsko74	54	16	]	]	-RRB-
cord-259347-3acsko74	54	17	.	.	.
cord-259347-3acsko74	55	1	However	however	RB
cord-259347-3acsko74	55	2	,	,	,
cord-259347-3acsko74	55	3	different	different	JJ
cord-259347-3acsko74	55	4	observations	observation	NNS
cord-259347-3acsko74	55	5	were	be	VBD
cord-259347-3acsko74	55	6	found	find	VBN
cord-259347-3acsko74	55	7	in	in	IN
cord-259347-3acsko74	55	8	another	another	DT
cord-259347-3acsko74	55	9	hACE2	hace2	NN
cord-259347-3acsko74	55	10	transgenic	transgenic	JJ
cord-259347-3acsko74	55	11	mouse	mouse	NN
cord-259347-3acsko74	55	12	model	model	NN
cord-259347-3acsko74	55	13	,	,	,
cord-259347-3acsko74	55	14	in	in	IN
cord-259347-3acsko74	55	15	which	which	WDT
cord-259347-3acsko74	55	16	no	no	DT
cord-259347-3acsko74	55	17	SARS	SARS	NNP
cord-259347-3acsko74	55	18	-	-	HYPH
cord-259347-3acsko74	55	19	CoV	CoV	NNP
cord-259347-3acsko74	55	20	was	be	VBD
cord-259347-3acsko74	55	21	detected	detect	VBN
cord-259347-3acsko74	55	22	in	in	IN
cord-259347-3acsko74	55	23	the	the	DT
cord-259347-3acsko74	55	24	olfactory	olfactory	JJ
cord-259347-3acsko74	55	25	bulb	bulb	NN
cord-259347-3acsko74	55	26	,	,	,
cord-259347-3acsko74	55	27	or	or	CC
cord-259347-3acsko74	55	28	preferentially	preferentially	RB
cord-259347-3acsko74	55	29	in	in	IN
cord-259347-3acsko74	55	30	sites	site	NNS
cord-259347-3acsko74	55	31	transneuronally	transneuronally	RB
cord-259347-3acsko74	55	32	connected	connect	VBN
cord-259347-3acsko74	55	33	to	to	IN
cord-259347-3acsko74	55	34	the	the	DT
cord-259347-3acsko74	55	35	olfactory	olfactory	JJ
cord-259347-3acsko74	55	36	bulb	bulb	NN
cord-259347-3acsko74	55	37	[	[	-LRB-
cord-259347-3acsko74	55	38	22	22	CD
cord-259347-3acsko74	55	39	]	]	-RRB-
cord-259347-3acsko74	55	40	.	.	.
cord-259347-3acsko74	56	1	In	in	IN
cord-259347-3acsko74	56	2	addition	addition	NN
cord-259347-3acsko74	56	3	,	,	,
cord-259347-3acsko74	56	4	a	a	DT
cord-259347-3acsko74	56	5	recent	recent	JJ
cord-259347-3acsko74	56	6	study	study	NN
cord-259347-3acsko74	56	7	has	have	VBZ
cord-259347-3acsko74	56	8	revealed	reveal	VBN
cord-259347-3acsko74	56	9	that	that	IN
cord-259347-3acsko74	56	10	ACE2	ACE2	NNP
cord-259347-3acsko74	56	11	(	(	-LRB-
cord-259347-3acsko74	56	12	Angiotensinconverting	Angiotensinconverting	NNP
cord-259347-3acsko74	56	13	Enzyme	Enzyme	NNP
cord-259347-3acsko74	56	14	2	2	CD
cord-259347-3acsko74	56	15	)	)	-RRB-
cord-259347-3acsko74	56	16	and	and	CC
cord-259347-3acsko74	56	17	TMPRSS2	TMPRSS2	NNP
cord-259347-3acsko74	56	18	(	(	-LRB-
cord-259347-3acsko74	56	19	transmembrane	transmembrane	NNP
cord-259347-3acsko74	56	20	protease	protease	NN
cord-259347-3acsko74	56	21	,	,	,
cord-259347-3acsko74	56	22	serine	serine	NN
cord-259347-3acsko74	56	23	2	2	CD
cord-259347-3acsko74	56	24	)	)	-RRB-
cord-259347-3acsko74	56	25	,	,	,
cord-259347-3acsko74	56	26	two	two	CD
cord-259347-3acsko74	56	27	key	key	JJ
cord-259347-3acsko74	56	28	genes	gene	NNS
cord-259347-3acsko74	56	29	involved	involve	VBN
cord-259347-3acsko74	56	30	in	in	IN
cord-259347-3acsko74	56	31	SARS	SARS	NNP
cord-259347-3acsko74	56	32	-	-	HYPH
cord-259347-3acsko74	56	33	CoV-2	CoV-2	NNP
cord-259347-3acsko74	56	34	entry	entry	NN
cord-259347-3acsko74	56	35	,	,	,
cord-259347-3acsko74	56	36	are	be	VBP
cord-259347-3acsko74	56	37	not	not	RB
cord-259347-3acsko74	56	38	expressed	express	VBN
cord-259347-3acsko74	56	39	in	in	IN
cord-259347-3acsko74	56	40	olfactory	olfactory	JJ
cord-259347-3acsko74	56	41	sensory	sensory	NN
cord-259347-3acsko74	56	42	or	or	CC
cord-259347-3acsko74	56	43	bulb	bulb	NN
cord-259347-3acsko74	56	44	neurons	neuron	NNS
cord-259347-3acsko74	56	45	,	,	,
cord-259347-3acsko74	56	46	but	but	CC
cord-259347-3acsko74	56	47	rather	rather	RB
cord-259347-3acsko74	56	48	in	in	IN
cord-259347-3acsko74	56	49	olfactory	olfactory	JJ
cord-259347-3acsko74	56	50	epithelial	epithelial	JJ
cord-259347-3acsko74	56	51	cells	cell	NNS
cord-259347-3acsko74	56	52	[	[	-LRB-
cord-259347-3acsko74	56	53	63	63	CD
cord-259347-3acsko74	56	54	]	]	-RRB-
cord-259347-3acsko74	56	55	,	,	,
cord-259347-3acsko74	56	56	suggesting	suggest	VBG
cord-259347-3acsko74	56	57	the	the	DT
cord-259347-3acsko74	56	58	involvement	involvement	NN
cord-259347-3acsko74	56	59	of	of	IN
cord-259347-3acsko74	56	60	other	other	JJ
cord-259347-3acsko74	56	61	dissemination	dissemination	NN
cord-259347-3acsko74	56	62	mechanisms	mechanism	NNS
cord-259347-3acsko74	56	63	independent	independent	JJ
cord-259347-3acsko74	56	64	of	of	IN
cord-259347-3acsko74	56	65	axonal	axonal	JJ
cord-259347-3acsko74	56	66	transport	transport	NN
cord-259347-3acsko74	56	67	.	.	.
cord-259347-3acsko74	57	1	It	-PRON-	PRP
cord-259347-3acsko74	57	2	has	have	VBZ
cord-259347-3acsko74	57	3	also	also	RB
cord-259347-3acsko74	57	4	been	be	VBN
cord-259347-3acsko74	57	5	proposed	propose	VBN
cord-259347-3acsko74	57	6	that	that	IN
cord-259347-3acsko74	57	7	hCoVs	hCoVs	NNP
cord-259347-3acsko74	57	8	can	can	MD
cord-259347-3acsko74	57	9	gain	gain	VB
cord-259347-3acsko74	57	10	access	access	NN
cord-259347-3acsko74	57	11	to	to	IN
cord-259347-3acsko74	57	12	the	the	DT
cord-259347-3acsko74	57	13	CNS	CNS	NNP
cord-259347-3acsko74	57	14	via	via	IN
cord-259347-3acsko74	57	15	the	the	DT
cord-259347-3acsko74	57	16	certain	certain	JJ
cord-259347-3acsko74	57	17	neurotransmitter	neurotransmitter	NN
cord-259347-3acsko74	57	18	pathways	pathway	NNS
cord-259347-3acsko74	57	19	such	such	JJ
cord-259347-3acsko74	57	20	as	as	IN
cord-259347-3acsko74	57	21	serotoninergic	serotoninergic	JJ
cord-259347-3acsko74	57	22	dorsal	dorsal	JJ
cord-259347-3acsko74	57	23	raphe	raphe	NNP
cord-259347-3acsko74	57	24	system	system	NN
cord-259347-3acsko74	57	25	[	[	-LRB-
cord-259347-3acsko74	57	26	18	18	CD
cord-259347-3acsko74	57	27	]	]	-RRB-
cord-259347-3acsko74	57	28	,	,	,
cord-259347-3acsko74	57	29	which	which	WDT
cord-259347-3acsko74	57	30	primarily	primarily	RB
cord-259347-3acsko74	57	31	projects	project	VBZ
cord-259347-3acsko74	57	32	to	to	IN
cord-259347-3acsko74	57	33	cerebral	cerebral	JJ
cord-259347-3acsko74	57	34	cortex	cortex	NN
cord-259347-3acsko74	57	35	,	,	,
cord-259347-3acsko74	57	36	neostriatum	neostriatum	NNP
cord-259347-3acsko74	57	37	,	,	,
cord-259347-3acsko74	57	38	amygdala	amygdala	NN
cord-259347-3acsko74	57	39	,	,	,
cord-259347-3acsko74	57	40	substantia	substantia	NNP
cord-259347-3acsko74	57	41	nigra	nigra	NNP
cord-259347-3acsko74	57	42	,	,	,
cord-259347-3acsko74	57	43	pons	pons	NNP
cord-259347-3acsko74	57	44	,	,	,
cord-259347-3acsko74	57	45	hippocampus	hippocampus	NN
cord-259347-3acsko74	57	46	,	,	,
cord-259347-3acsko74	57	47	entorhinal	entorhinal	NNP
cord-259347-3acsko74	57	48	cortex	cortex	NNP
cord-259347-3acsko74	57	49	and	and	CC
cord-259347-3acsko74	57	50	locus	locus	NN
cord-259347-3acsko74	57	51	coeruleus	coeruleu	VBZ
cord-259347-3acsko74	57	52	.	.	.
cord-259347-3acsko74	58	1	However	however	RB
cord-259347-3acsko74	58	2	,	,	,
cord-259347-3acsko74	58	3	this	this	DT
cord-259347-3acsko74	58	4	hypothesis	hypothesis	NN
cord-259347-3acsko74	58	5	is	be	VBZ
cord-259347-3acsko74	58	6	speculative	speculative	JJ
cord-259347-3acsko74	58	7	and	and	CC
cord-259347-3acsko74	58	8	requires	require	VBZ
cord-259347-3acsko74	58	9	to	to	TO
cord-259347-3acsko74	58	10	be	be	VB
cord-259347-3acsko74	58	11	further	further	RB
cord-259347-3acsko74	58	12	tested	test	VBN
cord-259347-3acsko74	58	13	in	in	IN
cord-259347-3acsko74	58	14	vivo	vivo	NN
cord-259347-3acsko74	58	15	models	model	NNS
cord-259347-3acsko74	58	16	.	.	.
cord-259347-3acsko74	59	1	Viremia	Viremia	NNP
cord-259347-3acsko74	59	2	has	have	VBZ
cord-259347-3acsko74	59	3	been	be	VBN
cord-259347-3acsko74	59	4	observed	observe	VBN
cord-259347-3acsko74	59	5	following	follow	VBG
cord-259347-3acsko74	59	6	intranasal	intranasal	NN
cord-259347-3acsko74	59	7	inoculation	inoculation	NN
cord-259347-3acsko74	59	8	with	with	IN
cord-259347-3acsko74	59	9	MHV	MHV	NNP
cord-259347-3acsko74	59	10	[	[	-LRB-
cord-259347-3acsko74	59	11	34	34	CD
cord-259347-3acsko74	59	12	]	]	-RRB-
cord-259347-3acsko74	59	13	and	and	CC
cord-259347-3acsko74	59	14	SARS	SARS	NNP
cord-259347-3acsko74	59	15	-	-	HYPH
cord-259347-3acsko74	59	16	CoV	CoV	NNP
cord-259347-3acsko74	59	17	[	[	-LRB-
cord-259347-3acsko74	59	18	21	21	CD
cord-259347-3acsko74	59	19	]	]	-RRB-
cord-259347-3acsko74	59	20	in	in	IN
cord-259347-3acsko74	59	21	transgenic	transgenic	JJ
cord-259347-3acsko74	59	22	mice	mouse	NNS
cord-259347-3acsko74	59	23	.	.	.
cord-259347-3acsko74	60	1	In	in	IN
cord-259347-3acsko74	60	2	addition	addition	NN
cord-259347-3acsko74	60	3	,	,	,
cord-259347-3acsko74	60	4	viral	viral	JJ
cord-259347-3acsko74	60	5	RNA	RNA	NNP
cord-259347-3acsko74	60	6	has	have	VBZ
cord-259347-3acsko74	60	7	been	be	VBN
cord-259347-3acsko74	60	8	measured	measure	VBN
cord-259347-3acsko74	60	9	in	in	IN
cord-259347-3acsko74	60	10	the	the	DT
cord-259347-3acsko74	60	11	blood	blood	NN
cord-259347-3acsko74	60	12	of	of	IN
cord-259347-3acsko74	60	13	patients	patient	NNS
cord-259347-3acsko74	60	14	infected	infect	VBN
cord-259347-3acsko74	60	15	with	with	IN
cord-259347-3acsko74	60	16	SARS	SARS	NNP
cord-259347-3acsko74	60	17	-	-	HYPH
cord-259347-3acsko74	60	18	CoV	CoV	NNP
cord-259347-3acsko74	60	19	and	and	CC
cord-259347-3acsko74	60	20	MERS	MERS	NNP
cord-259347-3acsko74	60	21	-	-	HYPH
cord-259347-3acsko74	60	22	CoV	CoV	NNP
cord-259347-3acsko74	60	23	[	[	-LRB-
cord-259347-3acsko74	60	24	35	35	CD
cord-259347-3acsko74	60	25	]	]	-RRB-
cord-259347-3acsko74	60	26	and	and	CC
cord-259347-3acsko74	60	27	thus	thus	RB
cord-259347-3acsko74	60	28	,	,	,
cord-259347-3acsko74	60	29	the	the	DT
cord-259347-3acsko74	60	30	dissemination	dissemination	NN
cord-259347-3acsko74	60	31	of	of	IN
cord-259347-3acsko74	60	32	these	these	DT
cord-259347-3acsko74	60	33	two	two	CD
cord-259347-3acsko74	60	34	viruses	virus	NNS
cord-259347-3acsko74	60	35	to	to	IN
cord-259347-3acsko74	60	36	the	the	DT
cord-259347-3acsko74	60	37	CNS	CNS	NNP
cord-259347-3acsko74	60	38	may	may	MD
cord-259347-3acsko74	60	39	be	be	VB
cord-259347-3acsko74	60	40	mediated	mediate	VBN
cord-259347-3acsko74	60	41	by	by	IN
cord-259347-3acsko74	60	42	the	the	DT
cord-259347-3acsko74	60	43	hematogenous	hematogenous	NNP
cord-259347-3acsko74	60	44	route	route	NN
cord-259347-3acsko74	60	45	through	through	IN
cord-259347-3acsko74	60	46	a	a	DT
cord-259347-3acsko74	60	47	damaged	damage	VBN
cord-259347-3acsko74	60	48	blood	blood	NN
cord-259347-3acsko74	60	49	-	-	HYPH
cord-259347-3acsko74	60	50	brain	brain	NN
cord-259347-3acsko74	60	51	barrier	barrier	NN
cord-259347-3acsko74	60	52	(	(	-LRB-
cord-259347-3acsko74	60	53	BBB	BBB	NNP
cord-259347-3acsko74	60	54	)	)	-RRB-
cord-259347-3acsko74	60	55	.	.	.
cord-259347-3acsko74	61	1	Once	once	IN
cord-259347-3acsko74	61	2	crossing	cross	VBG
cord-259347-3acsko74	61	3	the	the	DT
cord-259347-3acsko74	61	4	BBB	BBB	NNP
cord-259347-3acsko74	61	5	,	,	,
cord-259347-3acsko74	61	6	hCoVs	hCoVs	NNP
cord-259347-3acsko74	61	7	-	-	HYPH
cord-259347-3acsko74	61	8	infected	infect	VBN
cord-259347-3acsko74	61	9	cells	cell	NNS
cord-259347-3acsko74	61	10	could	could	MD
cord-259347-3acsko74	61	11	potentially	potentially	RB
cord-259347-3acsko74	61	12	invade	invade	VB
cord-259347-3acsko74	61	13	the	the	DT
cord-259347-3acsko74	61	14	brain	brain	NN
cord-259347-3acsko74	61	15	through	through	IN
cord-259347-3acsko74	61	16	perivascular	perivascular	JJ
cord-259347-3acsko74	61	17	spaces	space	NNS
cord-259347-3acsko74	61	18	,	,	,
cord-259347-3acsko74	61	19	also	also	RB
cord-259347-3acsko74	61	20	known	know	VBN
cord-259347-3acsko74	61	21	as	as	IN
cord-259347-3acsko74	61	22	Virchow	Virchow	NNP
cord-259347-3acsko74	61	23	-	-	HYPH
cord-259347-3acsko74	61	24	Robin	Robin	NNP
cord-259347-3acsko74	61	25	spaces	space	NNS
cord-259347-3acsko74	61	26	.	.	.
cord-259347-3acsko74	62	1	These	these	DT
cord-259347-3acsko74	62	2	fluid	fluid	NN
cord-259347-3acsko74	62	3	-	-	HYPH
cord-259347-3acsko74	62	4	filled	fill	VBN
cord-259347-3acsko74	62	5	spaces	space	NNS
cord-259347-3acsko74	62	6	are	be	VBP
cord-259347-3acsko74	62	7	implicated	implicate	VBN
cord-259347-3acsko74	62	8	as	as	IN
cord-259347-3acsko74	62	9	sites	site	NNS
cord-259347-3acsko74	62	10	in	in	IN
cord-259347-3acsko74	62	11	which	which	WDT
cord-259347-3acsko74	62	12	macrophages	macrophage	NNS
cord-259347-3acsko74	62	13	and	and	CC
cord-259347-3acsko74	62	14	lymphocytes	lymphocyte	NNS
cord-259347-3acsko74	62	15	interact	interact	VBP
cord-259347-3acsko74	62	16	to	to	TO
cord-259347-3acsko74	62	17	initiate	initiate	VB
cord-259347-3acsko74	62	18	immune	immune	JJ
cord-259347-3acsko74	62	19	response	response	NN
cord-259347-3acsko74	62	20	in	in	IN
cord-259347-3acsko74	62	21	patients	patient	NNS
cord-259347-3acsko74	62	22	with	with	IN
cord-259347-3acsko74	62	23	viral	viral	JJ
cord-259347-3acsko74	62	24	encephalitis	encephalitis	NN
cord-259347-3acsko74	62	25	[	[	-LRB-
cord-259347-3acsko74	62	26	36	36	CD
cord-259347-3acsko74	62	27	]	]	-RRB-
cord-259347-3acsko74	62	28	.	.	.
cord-259347-3acsko74	63	1	For	for	IN
cord-259347-3acsko74	63	2	instance	instance	NN
cord-259347-3acsko74	63	3	,	,	,
cord-259347-3acsko74	63	4	the	the	DT
cord-259347-3acsko74	63	5	cryptococcal	cryptococcal	JJ
cord-259347-3acsko74	63	6	organisms	organism	NNS
cord-259347-3acsko74	63	7	in	in	IN
cord-259347-3acsko74	63	8	AIDS	AIDS	NNP
cord-259347-3acsko74	63	9	patients	patient	NNS
cord-259347-3acsko74	63	10	have	have	VBP
cord-259347-3acsko74	63	11	been	be	VBN
cord-259347-3acsko74	63	12	shown	show	VBN
cord-259347-3acsko74	63	13	to	to	TO
cord-259347-3acsko74	63	14	disseminate	disseminate	VB
cord-259347-3acsko74	63	15	through	through	IN
cord-259347-3acsko74	63	16	the	the	DT
cord-259347-3acsko74	63	17	Virchow	Virchow	NNP
cord-259347-3acsko74	63	18	-	-	HYPH
cord-259347-3acsko74	63	19	Robin	Robin	NNP
cord-259347-3acsko74	63	20	spaces	space	NNS
cord-259347-3acsko74	63	21	before	before	IN
cord-259347-3acsko74	63	22	further	further	JJ
cord-259347-3acsko74	63	23	propagation	propagation	NN
cord-259347-3acsko74	63	24	into	into	IN
cord-259347-3acsko74	63	25	other	other	JJ
cord-259347-3acsko74	63	26	brain	brain	NN
cord-259347-3acsko74	63	27	regions	region	NNS
cord-259347-3acsko74	63	28	[	[	-LRB-
cord-259347-3acsko74	63	29	37	37	CD
cord-259347-3acsko74	63	30	]	]	-RRB-
cord-259347-3acsko74	63	31	.	.	.
cord-259347-3acsko74	64	1	Whether	whether	IN
cord-259347-3acsko74	64	2	hCoVs	hCoVs	NNP
cord-259347-3acsko74	64	3	could	could	MD
cord-259347-3acsko74	64	4	disseminate	disseminate	VB
cord-259347-3acsko74	64	5	via	via	IN
cord-259347-3acsko74	64	6	the	the	DT
cord-259347-3acsko74	64	7	same	same	JJ
cord-259347-3acsko74	64	8	route	route	NN
cord-259347-3acsko74	64	9	remains	remain	VBZ
cord-259347-3acsko74	64	10	unclear	unclear	JJ
cord-259347-3acsko74	64	11	.	.	.
cord-259347-3acsko74	65	1	The	the	DT
cord-259347-3acsko74	65	2	intranasal	intranasal	NN
cord-259347-3acsko74	65	3	inoculation	inoculation	NN
cord-259347-3acsko74	65	4	of	of	IN
cord-259347-3acsko74	65	5	rodents	rodent	NNS
cord-259347-3acsko74	65	6	with	with	IN
cord-259347-3acsko74	65	7	MHV	MHV	NNP
cord-259347-3acsko74	65	8	has	have	VBZ
cord-259347-3acsko74	65	9	also	also	RB
cord-259347-3acsko74	65	10	revealed	reveal	VBN
cord-259347-3acsko74	65	11	a	a	DT
cord-259347-3acsko74	65	12	lymphatic	lymphatic	JJ
cord-259347-3acsko74	65	13	dissemination	dissemination	NN
cord-259347-3acsko74	65	14	of	of	IN
cord-259347-3acsko74	65	15	coronavirus	coronavirus	NN
cord-259347-3acsko74	65	16	via	via	IN
cord-259347-3acsko74	65	17	cervical	cervical	JJ
cord-259347-3acsko74	65	18	and	and	CC
cord-259347-3acsko74	65	19	mesenteric	mesenteric	JJ
cord-259347-3acsko74	65	20	lymph	lymph	NN
cord-259347-3acsko74	65	21	nodes	node	NNS
cord-259347-3acsko74	65	22	in	in	IN
cord-259347-3acsko74	65	23	addition	addition	NN
cord-259347-3acsko74	65	24	to	to	IN
cord-259347-3acsko74	65	25	viremia	viremia	NNP
cord-259347-3acsko74	65	26	[	[	-LRB-
cord-259347-3acsko74	65	27	34	34	CD
cord-259347-3acsko74	65	28	]	]	-RRB-
cord-259347-3acsko74	65	29	.	.	.
cord-259347-3acsko74	66	1	Additional	additional	JJ
cord-259347-3acsko74	66	2	studies	study	NNS
cord-259347-3acsko74	66	3	are	be	VBP
cord-259347-3acsko74	66	4	required	require	VBN
cord-259347-3acsko74	66	5	to	to	TO
cord-259347-3acsko74	66	6	determine	determine	VB
cord-259347-3acsko74	66	7	the	the	DT
cord-259347-3acsko74	66	8	role	role	NN
cord-259347-3acsko74	66	9	of	of	IN
cord-259347-3acsko74	66	10	this	this	DT
cord-259347-3acsko74	66	11	potential	potential	JJ
cord-259347-3acsko74	66	12	dissemination	dissemination	NN
cord-259347-3acsko74	66	13	route	route	NN
cord-259347-3acsko74	66	14	.	.	.
cord-259347-3acsko74	67	1	The	the	DT
cord-259347-3acsko74	67	2	infection	infection	NN
cord-259347-3acsko74	67	3	of	of	IN
cord-259347-3acsko74	67	4	hCoVs	hCoVs	NNP
cord-259347-3acsko74	67	5	may	may	MD
cord-259347-3acsko74	67	6	also	also	RB
cord-259347-3acsko74	67	7	result	result	VB
cord-259347-3acsko74	67	8	in	in	IN
cord-259347-3acsko74	67	9	long	long	JJ
cord-259347-3acsko74	67	10	-	-	HYPH
cord-259347-3acsko74	67	11	term	term	NN
cord-259347-3acsko74	67	12	neurological	neurological	JJ
cord-259347-3acsko74	67	13	deficits	deficit	NNS
cord-259347-3acsko74	67	14	.	.	.
cord-259347-3acsko74	68	1	The	the	DT
cord-259347-3acsko74	68	2	pathologic	pathologic	JJ
cord-259347-3acsko74	68	3	examination	examination	NN
cord-259347-3acsko74	68	4	of	of	IN
cord-259347-3acsko74	68	5	brain	brain	NN
cord-259347-3acsko74	68	6	tissue	tissue	NN
cord-259347-3acsko74	68	7	collected	collect	VBN
cord-259347-3acsko74	68	8	from	from	IN
cord-259347-3acsko74	68	9	a	a	DT
cord-259347-3acsko74	68	10	SARS	SARS	NNP
cord-259347-3acsko74	68	11	patient	patient	NN
cord-259347-3acsko74	68	12	revealed	reveal	VBD
cord-259347-3acsko74	68	13	necrosis	necrosis	NN
cord-259347-3acsko74	68	14	of	of	IN
cord-259347-3acsko74	68	15	neurons	neuron	NNS
cord-259347-3acsko74	68	16	and	and	CC
cord-259347-3acsko74	68	17	broad	broad	JJ
cord-259347-3acsko74	68	18	hyperplasia	hyperplasia	NN
cord-259347-3acsko74	68	19	of	of	IN
cord-259347-3acsko74	68	20	gliocytes	gliocyte	NNS
cord-259347-3acsko74	68	21	,	,	,
cord-259347-3acsko74	68	22	indicative	indicative	JJ
cord-259347-3acsko74	68	23	of	of	IN
cord-259347-3acsko74	68	24	the	the	DT
cord-259347-3acsko74	68	25	presence	presence	NN
cord-259347-3acsko74	68	26	of	of	IN
cord-259347-3acsko74	68	27	a	a	DT
cord-259347-3acsko74	68	28	chronic	chronic	JJ
cord-259347-3acsko74	68	29	progressive	progressive	JJ
cord-259347-3acsko74	68	30	encephalitis	encephalitis	RB
cord-259347-3acsko74	68	31	during	during	IN
cord-259347-3acsko74	68	32	the	the	DT
cord-259347-3acsko74	68	33	course	course	NN
cord-259347-3acsko74	68	34	of	of	IN
cord-259347-3acsko74	68	35	viral	viral	JJ
cord-259347-3acsko74	68	36	infection	infection	NN
cord-259347-3acsko74	68	37	[	[	-LRB-
cord-259347-3acsko74	68	38	26	26	CD
cord-259347-3acsko74	68	39	]	]	-RRB-
cord-259347-3acsko74	68	40	.	.	.
cord-259347-3acsko74	69	1	In	in	IN
cord-259347-3acsko74	69	2	addition	addition	NN
cord-259347-3acsko74	69	3	,	,	,
cord-259347-3acsko74	69	4	scattered	scatter	VBD
cord-259347-3acsko74	69	5	red	red	JJ
cord-259347-3acsko74	69	6	degeneration	degeneration	NN
cord-259347-3acsko74	69	7	of	of	IN
cord-259347-3acsko74	69	8	neurons	neuron	NNS
cord-259347-3acsko74	69	9	,	,	,
cord-259347-3acsko74	69	10	a	a	DT
cord-259347-3acsko74	69	11	sign	sign	NN
cord-259347-3acsko74	69	12	of	of	IN
cord-259347-3acsko74	69	13	neuronal	neuronal	JJ
cord-259347-3acsko74	69	14	hypoxia	hypoxia	NN
cord-259347-3acsko74	69	15	or	or	CC
cord-259347-3acsko74	69	16	ischaemia	ischaemia	NN
cord-259347-3acsko74	69	17	[	[	-LRB-
cord-259347-3acsko74	69	18	27	27	CD
cord-259347-3acsko74	69	19	]	]	-RRB-
cord-259347-3acsko74	69	20	,	,	,
cord-259347-3acsko74	69	21	as	as	RB
cord-259347-3acsko74	69	22	well	well	RB
cord-259347-3acsko74	69	23	as	as	IN
cord-259347-3acsko74	69	24	oedema	oedema	NN
cord-259347-3acsko74	69	25	around	around	IN
cord-259347-3acsko74	69	26	small	small	JJ
cord-259347-3acsko74	69	27	veins	vein	NNS
cord-259347-3acsko74	69	28	with	with	IN
cord-259347-3acsko74	69	29	demyelination	demyelination	NN
cord-259347-3acsko74	69	30	of	of	IN
cord-259347-3acsko74	69	31	nerve	nerve	NN
cord-259347-3acsko74	69	32	fibres	fibre	NNS
cord-259347-3acsko74	69	33	[	[	-LRB-
cord-259347-3acsko74	69	34	38	38	CD
cord-259347-3acsko74	69	35	]	]	-RRB-
cord-259347-3acsko74	69	36	,	,	,
cord-259347-3acsko74	69	37	have	have	VBP
cord-259347-3acsko74	69	38	been	be	VBN
cord-259347-3acsko74	69	39	detected	detect	VBN
cord-259347-3acsko74	69	40	in	in	IN
cord-259347-3acsko74	69	41	brains	brain	NNS
cord-259347-3acsko74	69	42	of	of	IN
cord-259347-3acsko74	69	43	SARS	SARS	NNP
cord-259347-3acsko74	69	44	patients	patient	NNS
cord-259347-3acsko74	69	45	,	,	,
cord-259347-3acsko74	69	46	which	which	WDT
cord-259347-3acsko74	69	47	may	may	MD
cord-259347-3acsko74	69	48	provide	provide	VB
cord-259347-3acsko74	69	49	an	an	DT
cord-259347-3acsko74	69	50	explanation	explanation	NN
cord-259347-3acsko74	69	51	for	for	IN
cord-259347-3acsko74	69	52	an	an	DT
cord-259347-3acsko74	69	53	incidence	incidence	NN
cord-259347-3acsko74	69	54	of	of	IN
cord-259347-3acsko74	69	55	long	long	JJ
cord-259347-3acsko74	69	56	-	-	HYPH
cord-259347-3acsko74	69	57	term	term	NN
cord-259347-3acsko74	69	58	neurological	neurological	JJ
cord-259347-3acsko74	69	59	[	[	-LRB-
cord-259347-3acsko74	69	60	39	39	CD
cord-259347-3acsko74	69	61	]	]	-RRB-
cord-259347-3acsko74	70	1	and/or	and/or	CC
cord-259347-3acsko74	70	2	psychological	psychological	JJ
cord-259347-3acsko74	70	3	[	[	-LRB-
cord-259347-3acsko74	70	4	40	40	CD
cord-259347-3acsko74	70	5	]	]	-RRB-
cord-259347-3acsko74	70	6	abnormalities	abnormality	NNS
cord-259347-3acsko74	70	7	observed	observe	VBN
cord-259347-3acsko74	70	8	in	in	IN
cord-259347-3acsko74	70	9	SARS	SARS	NNP
cord-259347-3acsko74	70	10	survivors	survivor	NNS
cord-259347-3acsko74	70	11	.	.	.
cord-259347-3acsko74	71	1	In	in	IN
cord-259347-3acsko74	71	2	surviving	survive	VBG
cord-259347-3acsko74	71	3	mice	mouse	NNS
cord-259347-3acsko74	71	4	post	post	NN
cord-259347-3acsko74	71	5	hCoV	hCoV	NNP
cord-259347-3acsko74	71	6	-	-	HYPH
cord-259347-3acsko74	71	7	OC43	OC43	NNP
cord-259347-3acsko74	71	8	infection	infection	NN
cord-259347-3acsko74	71	9	,	,	,
cord-259347-3acsko74	71	10	spongiform	spongiform	NN
cord-259347-3acsko74	71	11	-	-	HYPH
cord-259347-3acsko74	71	12	like	like	JJ
cord-259347-3acsko74	71	13	degeneration	degeneration	NN
cord-259347-3acsko74	71	14	was	be	VBD
cord-259347-3acsko74	71	15	a	a	DT
cord-259347-3acsko74	71	16	residual	residual	JJ
cord-259347-3acsko74	71	17	finding	find	VBG
cord-259347-3acsko74	71	18	post	post	JJ
cord-259347-3acsko74	71	19	acute	acute	JJ
cord-259347-3acsko74	71	20	infection	infection	NN
cord-259347-3acsko74	71	21	,	,	,
cord-259347-3acsko74	71	22	indicating	indicate	VBG
cord-259347-3acsko74	71	23	the	the	DT
cord-259347-3acsko74	71	24	possibility	possibility	NN
cord-259347-3acsko74	71	25	of	of	IN
cord-259347-3acsko74	71	26	neurodegenerative	neurodegenerative	JJ
cord-259347-3acsko74	71	27	neuropathological	neuropathological	JJ
cord-259347-3acsko74	71	28	sequelae	sequela	NNS
cord-259347-3acsko74	71	29	[	[	-LRB-
cord-259347-3acsko74	71	30	4	4	CD
cord-259347-3acsko74	71	31	]	]	-RRB-
cord-259347-3acsko74	71	32	.	.	.
cord-259347-3acsko74	72	1	Further	further	RB
cord-259347-3acsko74	72	2	,	,	,
cord-259347-3acsko74	72	3	a	a	DT
cord-259347-3acsko74	72	4	decline	decline	NN
cord-259347-3acsko74	72	5	of	of	IN
cord-259347-3acsko74	72	6	locomotor	locomotor	NN
cord-259347-3acsko74	72	7	activity	activity	NN
cord-259347-3acsko74	72	8	and	and	CC
cord-259347-3acsko74	72	9	an	an	DT
cord-259347-3acsko74	72	10	abnormality	abnormality	NN
cord-259347-3acsko74	72	11	in	in	IN
cord-259347-3acsko74	72	12	the	the	DT
cord-259347-3acsko74	72	13	limb	limb	NN
cord-259347-3acsko74	72	14	clasping	clasp	VBG
cord-259347-3acsko74	72	15	reflex	reflex	NN
cord-259347-3acsko74	72	16	were	be	VBD
cord-259347-3acsko74	72	17	observed	observe	VBN
cord-259347-3acsko74	72	18	starting	start	VBG
cord-259347-3acsko74	72	19	several	several	JJ
cord-259347-3acsko74	72	20	months	month	NNS
cord-259347-3acsko74	72	21	after	after	IN
cord-259347-3acsko74	72	22	viral	viral	JJ
cord-259347-3acsko74	72	23	infection	infection	NN
cord-259347-3acsko74	72	24	,	,	,
cord-259347-3acsko74	72	25	and	and	CC
cord-259347-3acsko74	72	26	neuronal	neuronal	JJ
cord-259347-3acsko74	72	27	loss	loss	NN
cord-259347-3acsko74	72	28	especially	especially	RB
cord-259347-3acsko74	72	29	in	in	IN
cord-259347-3acsko74	72	30	the	the	DT
cord-259347-3acsko74	72	31	hippocampal	hippocampal	JJ
cord-259347-3acsko74	72	32	region	region	NN
cord-259347-3acsko74	72	33	was	be	VBD
cord-259347-3acsko74	72	34	still	still	RB
cord-259347-3acsko74	72	35	detectable	detectable	JJ
cord-259347-3acsko74	72	36	one	one	CD
cord-259347-3acsko74	72	37	year	year	NN
cord-259347-3acsko74	72	38	post	post	NN
cord-259347-3acsko74	72	39	infection	infection	NN
cord-259347-3acsko74	72	40	[	[	-LRB-
cord-259347-3acsko74	72	41	41	41	CD
cord-259347-3acsko74	72	42	]	]	-RRB-
cord-259347-3acsko74	72	43	.	.	.
cord-259347-3acsko74	73	1	Although	although	IN
cord-259347-3acsko74	73	2	the	the	DT
cord-259347-3acsko74	73	3	majority	majority	NN
cord-259347-3acsko74	73	4	of	of	IN
cord-259347-3acsko74	73	5	infectious	infectious	JJ
cord-259347-3acsko74	73	6	virus	virus	NN
cord-259347-3acsko74	73	7	(	(	-LRB-
cord-259347-3acsko74	73	8	80	80	CD
cord-259347-3acsko74	73	9	%	%	NN
cord-259347-3acsko74	73	10	)	)	-RRB-
cord-259347-3acsko74	73	11	was	be	VBD
cord-259347-3acsko74	73	12	cleared	clear	VBN
cord-259347-3acsko74	73	13	in	in	IN
cord-259347-3acsko74	73	14	surviving	survive	VBG
cord-259347-3acsko74	73	15	animals	animal	NNS
cord-259347-3acsko74	73	16	,	,	,
cord-259347-3acsko74	73	17	viral	viral	JJ
cord-259347-3acsko74	73	18	RNA	RNA	NNP
cord-259347-3acsko74	73	19	could	could	MD
cord-259347-3acsko74	73	20	persist	persist	VB
cord-259347-3acsko74	73	21	for	for	IN
cord-259347-3acsko74	73	22	months	month	NNS
cord-259347-3acsko74	73	23	[	[	-LRB-
cord-259347-3acsko74	73	24	41	41	CD
cord-259347-3acsko74	73	25	]	]	-RRB-
cord-259347-3acsko74	73	26	.	.	.
cord-259347-3acsko74	74	1	Even	even	RB
cord-259347-3acsko74	74	2	for	for	IN
cord-259347-3acsko74	74	3	cells	cell	NNS
cord-259347-3acsko74	74	4	that	that	WDT
cord-259347-3acsko74	74	5	have	have	VBP
cord-259347-3acsko74	74	6	survived	survive	VBN
cord-259347-3acsko74	74	7	the	the	DT
cord-259347-3acsko74	74	8	initial	initial	JJ
cord-259347-3acsko74	74	9	viral	viral	JJ
cord-259347-3acsko74	74	10	infection	infection	NN
cord-259347-3acsko74	74	11	,	,	,
cord-259347-3acsko74	74	12	little	little	JJ
cord-259347-3acsko74	74	13	is	be	VBZ
cord-259347-3acsko74	74	14	known	know	VBN
cord-259347-3acsko74	74	15	about	about	IN
cord-259347-3acsko74	74	16	their	-PRON-	PRP$
cord-259347-3acsko74	74	17	long	long	JJ
cord-259347-3acsko74	74	18	-	-	HYPH
cord-259347-3acsko74	74	19	term	term	NN
cord-259347-3acsko74	74	20	functional	functional	JJ
cord-259347-3acsko74	74	21	status	status	NN
cord-259347-3acsko74	74	22	.	.	.
cord-259347-3acsko74	75	1	To	to	TO
cord-259347-3acsko74	75	2	better	well	RBR
cord-259347-3acsko74	75	3	understand	understand	VB
cord-259347-3acsko74	75	4	this	this	DT
cord-259347-3acsko74	75	5	,	,	,
cord-259347-3acsko74	75	6	CoV	cov	NN
cord-259347-3acsko74	75	7	-	-	HYPH
cord-259347-3acsko74	75	8	infected	infect	VBN
cord-259347-3acsko74	75	9	models	model	NNS
cord-259347-3acsko74	75	10	that	that	WDT
cord-259347-3acsko74	75	11	allow	allow	VBP
cord-259347-3acsko74	75	12	the	the	DT
cord-259347-3acsko74	75	13	identification	identification	NN
cord-259347-3acsko74	75	14	and	and	CC
cord-259347-3acsko74	75	15	isolation	isolation	NN
cord-259347-3acsko74	75	16	of	of	IN
cord-259347-3acsko74	75	17	survival	survival	NN
cord-259347-3acsko74	75	18	cells	cell	NNS
cord-259347-3acsko74	75	19	,	,	,
cord-259347-3acsko74	75	20	such	such	JJ
cord-259347-3acsko74	75	21	as	as	IN
cord-259347-3acsko74	75	22	the	the	DT
cord-259347-3acsko74	75	23	Cre	Cre	NNP
cord-259347-3acsko74	75	24	reporter	reporter	NN
cord-259347-3acsko74	75	25	mouse	mouse	NN
cord-259347-3acsko74	75	26	model	model	NN
cord-259347-3acsko74	75	27	of	of	IN
cord-259347-3acsko74	75	28	MHV	MHV	NNP
cord-259347-3acsko74	75	29	infection	infection	NN
cord-259347-3acsko74	75	30	,	,	,
cord-259347-3acsko74	75	31	may	may	MD
cord-259347-3acsko74	75	32	be	be	VB
cord-259347-3acsko74	75	33	helpful	helpful	JJ
cord-259347-3acsko74	75	34	[	[	-LRB-
cord-259347-3acsko74	75	35	42	42	CD
cord-259347-3acsko74	75	36	]	]	-RRB-
cord-259347-3acsko74	75	37	.	.	.
cord-259347-3acsko74	76	1	Recovery	recovery	NN
cord-259347-3acsko74	76	2	from	from	IN
cord-259347-3acsko74	76	3	acute	acute	JJ
cord-259347-3acsko74	76	4	infection	infection	NN
cord-259347-3acsko74	76	5	does	do	VBZ
cord-259347-3acsko74	76	6	not	not	RB
cord-259347-3acsko74	76	7	necessarily	necessarily	RB
cord-259347-3acsko74	76	8	promise	promise	VB
cord-259347-3acsko74	76	9	complete	complete	JJ
cord-259347-3acsko74	76	10	clearance	clearance	NN
cord-259347-3acsko74	76	11	of	of	IN
cord-259347-3acsko74	76	12	the	the	DT
cord-259347-3acsko74	76	13	virus	virus	NN
cord-259347-3acsko74	76	14	,	,	,
cord-259347-3acsko74	76	15	and	and	CC
cord-259347-3acsko74	76	16	if	if	IN
cord-259347-3acsko74	76	17	an	an	DT
cord-259347-3acsko74	76	18	infection	infection	NN
cord-259347-3acsko74	76	19	were	be	VBD
cord-259347-3acsko74	76	20	to	to	TO
cord-259347-3acsko74	76	21	becomes	become	VBZ
cord-259347-3acsko74	76	22	chronic	chronic	JJ
cord-259347-3acsko74	76	23	,	,	,
cord-259347-3acsko74	76	24	it	-PRON-	PRP
cord-259347-3acsko74	76	25	may	may	MD
cord-259347-3acsko74	76	26	result	result	VB
cord-259347-3acsko74	76	27	in	in	IN
cord-259347-3acsko74	76	28	long	long	JJ
cord-259347-3acsko74	76	29	-	-	HYPH
cord-259347-3acsko74	76	30	term	term	NN
cord-259347-3acsko74	76	31	sequelae	sequela	NNS
cord-259347-3acsko74	76	32	including	include	VBG
cord-259347-3acsko74	76	33	chronic	chronic	JJ
cord-259347-3acsko74	76	34	neurological	neurological	JJ
cord-259347-3acsko74	76	35	diseases	disease	NNS
cord-259347-3acsko74	76	36	.	.	.
cord-259347-3acsko74	77	1	However	however	RB
cord-259347-3acsko74	77	2	,	,	,
cord-259347-3acsko74	77	3	given	give	VBN
cord-259347-3acsko74	77	4	the	the	DT
cord-259347-3acsko74	77	5	limited	limited	JJ
cord-259347-3acsko74	77	6	clinical	clinical	JJ
cord-259347-3acsko74	77	7	data	datum	NNS
cord-259347-3acsko74	77	8	,	,	,
cord-259347-3acsko74	77	9	the	the	DT
cord-259347-3acsko74	77	10	long	long	JJ
cord-259347-3acsko74	77	11	-	-	HYPH
cord-259347-3acsko74	77	12	term	term	NN
cord-259347-3acsko74	77	13	effects	effect	NNS
cord-259347-3acsko74	77	14	of	of	IN
cord-259347-3acsko74	77	15	hCoVs	hcovs	NN
cord-259347-3acsko74	77	16	on	on	IN
cord-259347-3acsko74	77	17	the	the	DT
cord-259347-3acsko74	77	18	CNS	CNS	NNP
cord-259347-3acsko74	77	19	post	post	NN
cord-259347-3acsko74	77	20	acute	acute	JJ
cord-259347-3acsko74	77	21	infection	infection	NN
cord-259347-3acsko74	77	22	are	be	VBP
cord-259347-3acsko74	77	23	unknown	unknown	JJ
cord-259347-3acsko74	77	24	and	and	CC
cord-259347-3acsko74	77	25	thus	thus	RB
cord-259347-3acsko74	77	26	,	,	,
cord-259347-3acsko74	77	27	more	more	JJR
cord-259347-3acsko74	77	28	studies	study	NNS
cord-259347-3acsko74	77	29	involving	involve	VBG
cord-259347-3acsko74	77	30	the	the	DT
cord-259347-3acsko74	77	31	long	long	JJ
cord-259347-3acsko74	77	32	-	-	HYPH
cord-259347-3acsko74	77	33	term	term	NN
cord-259347-3acsko74	77	34	follow	follow	NN
cord-259347-3acsko74	77	35	-	-	HYPH
cord-259347-3acsko74	77	36	up	up	NN
cord-259347-3acsko74	77	37	of	of	IN
cord-259347-3acsko74	77	38	survivors	survivor	NNS
cord-259347-3acsko74	77	39	are	be	VBP
cord-259347-3acsko74	77	40	needed	need	VBN
cord-259347-3acsko74	77	41	.	.	.
cord-259347-3acsko74	78	1	ACE2	ACE2	NNP
cord-259347-3acsko74	78	2	was	be	VBD
cord-259347-3acsko74	78	3	reported	report	VBN
cord-259347-3acsko74	78	4	as	as	IN
cord-259347-3acsko74	78	5	a	a	DT
cord-259347-3acsko74	78	6	functional	functional	JJ
cord-259347-3acsko74	78	7	cellular	cellular	JJ
cord-259347-3acsko74	78	8	receptor	receptor	NN
cord-259347-3acsko74	78	9	for	for	IN
cord-259347-3acsko74	78	10	SARS	SARS	NNP
cord-259347-3acsko74	78	11	-	-	HYPH
cord-259347-3acsko74	78	12	CoV	CoV	NNP
cord-259347-3acsko74	78	13	due	due	IN
cord-259347-3acsko74	78	14	to	to	IN
cord-259347-3acsko74	78	15	the	the	DT
cord-259347-3acsko74	78	16	ability	ability	NN
cord-259347-3acsko74	78	17	of	of	IN
cord-259347-3acsko74	78	18	the	the	DT
cord-259347-3acsko74	78	19	S1	S1	NNP
cord-259347-3acsko74	78	20	domain	domain	NN
cord-259347-3acsko74	78	21	of	of	IN
cord-259347-3acsko74	78	22	the	the	DT
cord-259347-3acsko74	78	23	spike	spike	NN
cord-259347-3acsko74	78	24	(	(	-LRB-
cord-259347-3acsko74	78	25	S	s	NN
cord-259347-3acsko74	78	26	)	)	-RRB-
cord-259347-3acsko74	78	27	protein	protein	NN
cord-259347-3acsko74	78	28	to	to	TO
cord-259347-3acsko74	78	29	efficiently	efficiently	RB
cord-259347-3acsko74	78	30	bind	bind	VB
cord-259347-3acsko74	78	31	to	to	IN
cord-259347-3acsko74	78	32	ACE2	ACE2	NNP
cord-259347-3acsko74	78	33	for	for	IN
cord-259347-3acsko74	78	34	subsequent	subsequent	JJ
cord-259347-3acsko74	78	35	viral	viral	JJ
cord-259347-3acsko74	78	36	replication	replication	NN
cord-259347-3acsko74	78	37	in	in	IN
cord-259347-3acsko74	78	38	the	the	DT
cord-259347-3acsko74	78	39	cytoplasm	cytoplasm	NN
cord-259347-3acsko74	78	40	of	of	IN
cord-259347-3acsko74	78	41	sensitive	sensitive	JJ
cord-259347-3acsko74	78	42	cells	cell	NNS
cord-259347-3acsko74	78	43	[	[	-LRB-
cord-259347-3acsko74	78	44	43	43	CD
cord-259347-3acsko74	78	45	]	]	-RRB-
cord-259347-3acsko74	78	46	.	.	.
cord-259347-3acsko74	79	1	In	in	IN
cord-259347-3acsko74	79	2	addition	addition	NN
cord-259347-3acsko74	79	3	,	,	,
cord-259347-3acsko74	79	4	previous	previous	JJ
cord-259347-3acsko74	79	5	autopsy	autopsy	JJ
cord-259347-3acsko74	79	6	studies	study	NNS
cord-259347-3acsko74	79	7	have	have	VBP
cord-259347-3acsko74	79	8	inferred	infer	VBN
cord-259347-3acsko74	79	9	that	that	IN
cord-259347-3acsko74	79	10	only	only	RB
cord-259347-3acsko74	79	11	ACE2-postive	ace2-postive	JJ
cord-259347-3acsko74	79	12	cells	cell	NNS
cord-259347-3acsko74	79	13	were	be	VBD
cord-259347-3acsko74	79	14	susceptible	susceptible	JJ
cord-259347-3acsko74	79	15	to	to	IN
cord-259347-3acsko74	79	16	SARS	SARS	NNP
cord-259347-3acsko74	79	17	-	-	HYPH
cord-259347-3acsko74	79	18	CoV	CoV	NNP
cord-259347-3acsko74	79	19	infection	infection	NN
cord-259347-3acsko74	79	20	because	because	IN
cord-259347-3acsko74	79	21	the	the	DT
cord-259347-3acsko74	79	22	S	S	NNP
cord-259347-3acsko74	79	23	protein	protein	NN
cord-259347-3acsko74	79	24	and	and	CC
cord-259347-3acsko74	79	25	its	-PRON-	PRP$
cord-259347-3acsko74	79	26	RNA	RNA	NNP
cord-259347-3acsko74	79	27	could	could	MD
cord-259347-3acsko74	79	28	not	not	RB
cord-259347-3acsko74	79	29	be	be	VB
cord-259347-3acsko74	79	30	detected	detect	VBN
cord-259347-3acsko74	79	31	in	in	IN
cord-259347-3acsko74	79	32	ACE2-negative	ace2-negative	JJ
cord-259347-3acsko74	79	33	cells	cell	NNS
cord-259347-3acsko74	79	34	[	[	-LRB-
cord-259347-3acsko74	79	35	44	44	CD
cord-259347-3acsko74	79	36	]	]	-RRB-
cord-259347-3acsko74	79	37	.	.	.
cord-259347-3acsko74	80	1	It	-PRON-	PRP
cord-259347-3acsko74	80	2	has	have	VBZ
cord-259347-3acsko74	80	3	been	be	VBN
cord-259347-3acsko74	80	4	reported	report	VBN
cord-259347-3acsko74	80	5	that	that	IN
cord-259347-3acsko74	80	6	SARS	SARS	NNP
cord-259347-3acsko74	80	7	-	-	HYPH
cord-259347-3acsko74	80	8	CoV-2	CoV-2	NNP
cord-259347-3acsko74	80	9	might	may	MD
cord-259347-3acsko74	80	10	also	also	RB
cord-259347-3acsko74	80	11	use	use	VB
cord-259347-3acsko74	80	12	ACE2	ACE2	NNP
cord-259347-3acsko74	80	13	as	as	IN
cord-259347-3acsko74	80	14	a	a	DT
cord-259347-3acsko74	80	15	cellular	cellular	JJ
cord-259347-3acsko74	80	16	receptor	receptor	NN
cord-259347-3acsko74	80	17	,	,	,
cord-259347-3acsko74	80	18	despite	despite	IN
cord-259347-3acsko74	80	19	a	a	DT
cord-259347-3acsko74	80	20	variation	variation	NN
cord-259347-3acsko74	80	21	at	at	IN
cord-259347-3acsko74	80	22	some	some	DT
cord-259347-3acsko74	80	23	key	key	JJ
cord-259347-3acsko74	80	24	residues	residue	NNS
cord-259347-3acsko74	80	25	of	of	IN
cord-259347-3acsko74	80	26	the	the	DT
cord-259347-3acsko74	80	27	receptor	receptor	NN
cord-259347-3acsko74	80	28	-	-	HYPH
cord-259347-3acsko74	80	29	binding	bind	VBG
cord-259347-3acsko74	80	30	domain	domain	NN
cord-259347-3acsko74	80	31	compared	compare	VBN
cord-259347-3acsko74	80	32	to	to	IN
cord-259347-3acsko74	80	33	that	that	DT
cord-259347-3acsko74	80	34	of	of	IN
cord-259347-3acsko74	80	35	SARS	SARS	NNP
cord-259347-3acsko74	80	36	-	-	HYPH
cord-259347-3acsko74	80	37	CoV	CoV	NNP
cord-259347-3acsko74	80	38	[	[	-LRB-
cord-259347-3acsko74	80	39	6	6	CD
cord-259347-3acsko74	80	40	]	]	-RRB-
cord-259347-3acsko74	80	41	.	.	.
cord-259347-3acsko74	81	1	The	the	DT
cord-259347-3acsko74	81	2	lack	lack	NN
cord-259347-3acsko74	81	3	of	of	IN
cord-259347-3acsko74	81	4	ACE2	ACE2	NNP
cord-259347-3acsko74	81	5	expression	expression	NN
cord-259347-3acsko74	81	6	in	in	IN
cord-259347-3acsko74	81	7	neuronal	neuronal	JJ
cord-259347-3acsko74	81	8	cells	cell	NNS
cord-259347-3acsko74	81	9	at	at	IN
cord-259347-3acsko74	81	10	both	both	DT
cord-259347-3acsko74	81	11	transcription	transcription	NN
cord-259347-3acsko74	81	12	and	and	CC
cord-259347-3acsko74	81	13	protein	protein	NN
cord-259347-3acsko74	81	14	level	level	NN
cord-259347-3acsko74	81	15	contrasts	contrast	VBZ
cord-259347-3acsko74	81	16	with	with	IN
cord-259347-3acsko74	81	17	the	the	DT
cord-259347-3acsko74	81	18	viral	viral	JJ
cord-259347-3acsko74	81	19	susceptibility	susceptibility	NN
cord-259347-3acsko74	81	20	of	of	IN
cord-259347-3acsko74	81	21	these	these	DT
cord-259347-3acsko74	81	22	cells	cell	NNS
cord-259347-3acsko74	81	23	and	and	CC
cord-259347-3acsko74	81	24	cytopathogenicity	cytopathogenicity	NN
cord-259347-3acsko74	81	25	during	during	IN
cord-259347-3acsko74	81	26	the	the	DT
cord-259347-3acsko74	81	27	acute	acute	JJ
cord-259347-3acsko74	81	28	phase	phase	NN
cord-259347-3acsko74	81	29	of	of	IN
cord-259347-3acsko74	81	30	infection	infection	NN
cord-259347-3acsko74	81	31	in	in	IN
cord-259347-3acsko74	81	32	neural	neural	JJ
cord-259347-3acsko74	81	33	cell	cell	NN
cord-259347-3acsko74	81	34	lines	line	NNS
cord-259347-3acsko74	81	35	of	of	IN
cord-259347-3acsko74	81	36	human	human	NN
cord-259347-3acsko74	81	37	and	and	CC
cord-259347-3acsko74	81	38	rat	rat	NN
cord-259347-3acsko74	81	39	origins	origin	NNS
cord-259347-3acsko74	81	40	[	[	-LRB-
cord-259347-3acsko74	81	41	17	17	CD
cord-259347-3acsko74	81	42	]	]	-RRB-
cord-259347-3acsko74	81	43	as	as	RB
cord-259347-3acsko74	81	44	well	well	RB
cord-259347-3acsko74	81	45	as	as	IN
cord-259347-3acsko74	81	46	in	in	IN
cord-259347-3acsko74	81	47	humans	human	NNS
cord-259347-3acsko74	81	48	brains	brain	NNS
cord-259347-3acsko74	81	49	[	[	-LRB-
cord-259347-3acsko74	81	50	45	45	CD
cord-259347-3acsko74	81	51	]	]	-RRB-
cord-259347-3acsko74	81	52	.	.	.
cord-259347-3acsko74	82	1	Even	even	RB
cord-259347-3acsko74	82	2	in	in	IN
cord-259347-3acsko74	82	3	hACE2	hace2	NN
cord-259347-3acsko74	82	4	transgenic	transgenic	JJ
cord-259347-3acsko74	82	5	mice	mouse	NNS
cord-259347-3acsko74	82	6	,	,	,
cord-259347-3acsko74	82	7	when	when	WRB
cord-259347-3acsko74	82	8	specific	specific	JJ
cord-259347-3acsko74	82	9	brain	brain	NN
cord-259347-3acsko74	82	10	regions	region	NNS
cord-259347-3acsko74	82	11	were	be	VBD
cord-259347-3acsko74	82	12	heavily	heavily	RB
cord-259347-3acsko74	82	13	infected	infect	VBN
cord-259347-3acsko74	82	14	by	by	IN
cord-259347-3acsko74	82	15	SARS	SARS	NNP
cord-259347-3acsko74	82	16	-	-	HYPH
cord-259347-3acsko74	82	17	CoV	CoV	NNP
cord-259347-3acsko74	82	18	,	,	,
cord-259347-3acsko74	82	19	the	the	DT
cord-259347-3acsko74	82	20	expression	expression	NN
cord-259347-3acsko74	82	21	levels	level	NNS
cord-259347-3acsko74	82	22	of	of	IN
cord-259347-3acsko74	82	23	hACE2	hace2	NN
cord-259347-3acsko74	82	24	in	in	IN
cord-259347-3acsko74	82	25	the	the	DT
cord-259347-3acsko74	82	26	brain	brain	NN
cord-259347-3acsko74	82	27	were	be	VBD
cord-259347-3acsko74	82	28	no	no	RB
cord-259347-3acsko74	82	29	more	more	JJR
cord-259347-3acsko74	82	30	than	than	IN
cord-259347-3acsko74	82	31	01	01	CD
cord-259347-3acsko74	82	32	to	to	IN
cord-259347-3acsko74	82	33	1	1	CD
cord-259347-3acsko74	82	34	%	%	NN
cord-259347-3acsko74	82	35	of	of	IN
cord-259347-3acsko74	82	36	those	those	DT
cord-259347-3acsko74	82	37	found	find	VBN
cord-259347-3acsko74	82	38	in	in	IN
cord-259347-3acsko74	82	39	the	the	DT
cord-259347-3acsko74	82	40	lungs	lung	NNS
cord-259347-3acsko74	82	41	[	[	-LRB-
cord-259347-3acsko74	82	42	18	18	CD
cord-259347-3acsko74	82	43	]	]	-RRB-
cord-259347-3acsko74	82	44	.	.	.
cord-259347-3acsko74	83	1	Furthermore	furthermore	RB
cord-259347-3acsko74	83	2	,	,	,
cord-259347-3acsko74	83	3	even	even	RB
cord-259347-3acsko74	83	4	in	in	IN
cord-259347-3acsko74	83	5	cells	cell	NNS
cord-259347-3acsko74	83	6	highly	highly	RB
cord-259347-3acsko74	83	7	expressing	express	VBG
cord-259347-3acsko74	83	8	hACE2	hace2	NN
cord-259347-3acsko74	83	9	in	in	IN
cord-259347-3acsko74	83	10	the	the	DT
cord-259347-3acsko74	83	11	transgenic	transgenic	JJ
cord-259347-3acsko74	83	12	animal	animal	NN
cord-259347-3acsko74	83	13	model	model	NN
cord-259347-3acsko74	83	14	,	,	,
cord-259347-3acsko74	83	15	SARS	SARS	NNP
cord-259347-3acsko74	83	16	-	-	HYPH
cord-259347-3acsko74	83	17	CoV	CoV	NNP
cord-259347-3acsko74	83	18	infection	infection	NN
cord-259347-3acsko74	83	19	could	could	MD
cord-259347-3acsko74	83	20	be	be	VB
cord-259347-3acsko74	83	21	absent	absent	JJ
cord-259347-3acsko74	83	22	,	,	,
cord-259347-3acsko74	83	23	indicating	indicate	VBG
cord-259347-3acsko74	83	24	that	that	IN
cord-259347-3acsko74	83	25	the	the	DT
cord-259347-3acsko74	83	26	expression	expression	NN
cord-259347-3acsko74	83	27	of	of	IN
cord-259347-3acsko74	83	28	hACE2	hace2	NN
cord-259347-3acsko74	83	29	alone	alone	RB
cord-259347-3acsko74	83	30	might	may	MD
cord-259347-3acsko74	83	31	not	not	RB
cord-259347-3acsko74	83	32	be	be	VB
cord-259347-3acsko74	83	33	sufficient	sufficient	JJ
cord-259347-3acsko74	83	34	for	for	IN
cord-259347-3acsko74	83	35	maintaining	maintain	VBG
cord-259347-3acsko74	83	36	viral	viral	JJ
cord-259347-3acsko74	83	37	infection	infection	NN
cord-259347-3acsko74	83	38	[	[	-LRB-
cord-259347-3acsko74	83	39	46	46	CD
cord-259347-3acsko74	83	40	]	]	-RRB-
cord-259347-3acsko74	83	41	.	.	.
cord-259347-3acsko74	84	1	These	these	DT
cord-259347-3acsko74	84	2	findings	finding	NNS
cord-259347-3acsko74	84	3	suggest	suggest	VBP
cord-259347-3acsko74	84	4	that	that	IN
cord-259347-3acsko74	84	5	other	other	JJ
cord-259347-3acsko74	84	6	receptor	receptor	NN
cord-259347-3acsko74	84	7	(	(	-LRB-
cord-259347-3acsko74	84	8	s	s	NN
cord-259347-3acsko74	84	9	)	)	-RRB-
cord-259347-3acsko74	84	10	or	or	CC
cord-259347-3acsko74	84	11	co	co	JJ
cord-259347-3acsko74	84	12	-	-	JJ
cord-259347-3acsko74	84	13	receptor(s	receptor(s	JJ
cord-259347-3acsko74	84	14	)	)	-RRB-
cord-259347-3acsko74	84	15	are	be	VBP
cord-259347-3acsko74	84	16	involved	involve	VBN
cord-259347-3acsko74	84	17	in	in	IN
cord-259347-3acsko74	84	18	the	the	DT
cord-259347-3acsko74	84	19	viral	viral	JJ
cord-259347-3acsko74	84	20	entry	entry	NN
cord-259347-3acsko74	84	21	into	into	IN
cord-259347-3acsko74	84	22	neural	neural	JJ
cord-259347-3acsko74	84	23	cells	cell	NNS
cord-259347-3acsko74	84	24	.	.	.
cord-259347-3acsko74	85	1	DPP-4	DPP-4	NNP
cord-259347-3acsko74	86	1	(	(	-LRB-
cord-259347-3acsko74	86	2	also	also	RB
cord-259347-3acsko74	86	3	known	know	VBN
cord-259347-3acsko74	86	4	as	as	IN
cord-259347-3acsko74	86	5	CD26	CD26	NNP
cord-259347-3acsko74	86	6	)	)	-RRB-
cord-259347-3acsko74	86	7	was	be	VBD
cord-259347-3acsko74	86	8	identified	identify	VBN
cord-259347-3acsko74	86	9	as	as	IN
cord-259347-3acsko74	86	10	a	a	DT
cord-259347-3acsko74	86	11	cellular	cellular	JJ
cord-259347-3acsko74	86	12	receptor	receptor	NN
cord-259347-3acsko74	86	13	for	for	IN
cord-259347-3acsko74	86	14	MERS	MERS	NNP
cord-259347-3acsko74	86	15	-	-	HYPH
cord-259347-3acsko74	86	16	CoV	CoV	NNP
cord-259347-3acsko74	86	17	[	[	-LRB-
cord-259347-3acsko74	86	18	47	47	CD
cord-259347-3acsko74	86	19	]	]	-RRB-
cord-259347-3acsko74	86	20	.	.	.
cord-259347-3acsko74	87	1	Two	two	CD
cord-259347-3acsko74	87	2	lines	line	NNS
cord-259347-3acsko74	87	3	of	of	IN
cord-259347-3acsko74	87	4	human	human	JJ
cord-259347-3acsko74	87	5	DPP-4	DPP-4	NNP
cord-259347-3acsko74	87	6	transgenic	transgenic	JJ
cord-259347-3acsko74	87	7	mice	mouse	NNS
cord-259347-3acsko74	87	8	were	be	VBD
cord-259347-3acsko74	87	9	found	find	VBN
cord-259347-3acsko74	87	10	to	to	TO
cord-259347-3acsko74	87	11	have	have	VB
cord-259347-3acsko74	87	12	high	high	JJ
cord-259347-3acsko74	87	13	affinity	affinity	NN
cord-259347-3acsko74	87	14	to	to	IN
cord-259347-3acsko74	87	15	infection	infection	NN
cord-259347-3acsko74	87	16	by	by	IN
cord-259347-3acsko74	87	17	MERS	MERS	NNP
cord-259347-3acsko74	87	18	-	-	HYPH
cord-259347-3acsko74	87	19	CoV	CoV	NNP
cord-259347-3acsko74	87	20	[	[	-LRB-
cord-259347-3acsko74	87	21	24	24	CD
cord-259347-3acsko74	87	22	,	,	,
cord-259347-3acsko74	87	23	25	25	CD
cord-259347-3acsko74	87	24	]	]	-RRB-
cord-259347-3acsko74	87	25	.	.	.
cord-259347-3acsko74	88	1	DPP-4	DPP-4	NNP
cord-259347-3acsko74	88	2	is	be	VBZ
cord-259347-3acsko74	88	3	expressed	express	VBN
cord-259347-3acsko74	88	4	in	in	IN
cord-259347-3acsko74	88	5	human	human	JJ
cord-259347-3acsko74	88	6	brains	brain	NNS
cord-259347-3acsko74	88	7	[	[	-LRB-
cord-259347-3acsko74	88	8	48	48	CD
cord-259347-3acsko74	88	9	]	]	-RRB-
cord-259347-3acsko74	88	10	,	,	,
cord-259347-3acsko74	88	11	therefore	therefore	RB
cord-259347-3acsko74	88	12	,	,	,
cord-259347-3acsko74	88	13	when	when	WRB
cord-259347-3acsko74	88	14	the	the	DT
cord-259347-3acsko74	88	15	virus	virus	NN
cord-259347-3acsko74	88	16	gains	gain	VBZ
cord-259347-3acsko74	88	17	access	access	NN
cord-259347-3acsko74	88	18	to	to	IN
cord-259347-3acsko74	88	19	the	the	DT
cord-259347-3acsko74	88	20	brain	brain	NN
cord-259347-3acsko74	88	21	,	,	,
cord-259347-3acsko74	88	22	cells	cell	NNS
cord-259347-3acsko74	88	23	expressing	express	VBG
cord-259347-3acsko74	88	24	DPP-4	DPP-4	NNP
cord-259347-3acsko74	88	25	are	be	VBP
cord-259347-3acsko74	88	26	potentially	potentially	RB
cord-259347-3acsko74	88	27	available	available	JJ
cord-259347-3acsko74	88	28	for	for	IN
cord-259347-3acsko74	88	29	viral	viral	JJ
cord-259347-3acsko74	88	30	replication	replication	NN
cord-259347-3acsko74	88	31	within	within	IN
cord-259347-3acsko74	88	32	the	the	DT
cord-259347-3acsko74	88	33	CNS	CNS	NNP
cord-259347-3acsko74	88	34	.	.	.
cord-259347-3acsko74	89	1	Aminopeptidase	Aminopeptidase	NNP
cord-259347-3acsko74	89	2	N	N	NNP
cord-259347-3acsko74	89	3	(	(	-LRB-
cord-259347-3acsko74	89	4	APN	APN	NNP
cord-259347-3acsko74	89	5	,	,	,
cord-259347-3acsko74	89	6	also	also	RB
cord-259347-3acsko74	89	7	known	know	VBN
cord-259347-3acsko74	89	8	as	as	IN
cord-259347-3acsko74	89	9	CD13	CD13	NNP
cord-259347-3acsko74	89	10	)	)	-RRB-
cord-259347-3acsko74	89	11	,	,	,
cord-259347-3acsko74	89	12	a	a	DT
cord-259347-3acsko74	89	13	cell	cell	NN
cord-259347-3acsko74	89	14	-	-	HYPH
cord-259347-3acsko74	89	15	surface	surface	NN
cord-259347-3acsko74	89	16	metalloprotease	metalloprotease	NN
cord-259347-3acsko74	89	17	,	,	,
cord-259347-3acsko74	89	18	was	be	VBD
cord-259347-3acsko74	89	19	proposed	propose	VBN
cord-259347-3acsko74	89	20	as	as	IN
cord-259347-3acsko74	89	21	a	a	DT
cord-259347-3acsko74	89	22	receptor	receptor	NN
cord-259347-3acsko74	89	23	for	for	IN
cord-259347-3acsko74	89	24	hCoV	hcov	ADD
cord-259347-3acsko74	89	25	229E	229e	CD
cord-259347-3acsko74	89	26	[	[	-LRB-
cord-259347-3acsko74	89	27	49	49	CD
cord-259347-3acsko74	89	28	]	]	-RRB-
cord-259347-3acsko74	89	29	,	,	,
cord-259347-3acsko74	89	30	as	as	RB
cord-259347-3acsko74	89	31	well	well	RB
cord-259347-3acsko74	89	32	as	as	IN
cord-259347-3acsko74	89	33	SARS	SARS	NNP
cord-259347-3acsko74	89	34	-	-	HYPH
cord-259347-3acsko74	89	35	CoV	CoV	NNP
cord-259347-3acsko74	89	36	[	[	-LRB-
cord-259347-3acsko74	89	37	50	50	CD
cord-259347-3acsko74	89	38	]	]	-RRB-
cord-259347-3acsko74	89	39	.	.	.
cord-259347-3acsko74	90	1	Human	human	JJ
cord-259347-3acsko74	90	2	aminopeptidase	aminopeptidase	NN
cord-259347-3acsko74	90	3	N	N	NNP
cord-259347-3acsko74	90	4	was	be	VBD
cord-259347-3acsko74	90	5	shown	show	VBN
cord-259347-3acsko74	90	6	,	,	,
cord-259347-3acsko74	90	7	in	in	IN
cord-259347-3acsko74	90	8	vitro	vitro	FW
cord-259347-3acsko74	90	9	,	,	,
cord-259347-3acsko74	90	10	to	to	TO
cord-259347-3acsko74	90	11	be	be	VB
cord-259347-3acsko74	90	12	a	a	DT
cord-259347-3acsko74	90	13	cellular	cellular	JJ
cord-259347-3acsko74	90	14	receptor	receptor	NN
cord-259347-3acsko74	90	15	for	for	IN
cord-259347-3acsko74	90	16	hCoV	hCoV	NNP
cord-259347-3acsko74	90	17	229E	229e	CD
cord-259347-3acsko74	90	18	infection	infection	NN
cord-259347-3acsko74	90	19	of	of	IN
cord-259347-3acsko74	90	20	human	human	JJ
cord-259347-3acsko74	90	21	neuronal	neuronal	JJ
cord-259347-3acsko74	90	22	,	,	,
cord-259347-3acsko74	90	23	astrocytic	astrocytic	JJ
cord-259347-3acsko74	90	24	and	and	CC
cord-259347-3acsko74	90	25	oligodendrocytic	oligodendrocytic	JJ
cord-259347-3acsko74	90	26	cell	cell	NN
cord-259347-3acsko74	90	27	lines	line	NNS
cord-259347-3acsko74	90	28	[	[	-LRB-
cord-259347-3acsko74	90	29	51	51	CD
cord-259347-3acsko74	90	30	]	]	-RRB-
cord-259347-3acsko74	90	31	.	.	.
cord-259347-3acsko74	91	1	Another	another	DT
cord-259347-3acsko74	91	2	glycoprotein	glycoprotein	NN
cord-259347-3acsko74	91	3	,	,	,
cord-259347-3acsko74	91	4	namely	namely	RB
cord-259347-3acsko74	91	5	CD209L	CD209L	NNP
cord-259347-3acsko74	91	6	(	(	-LRB-
cord-259347-3acsko74	91	7	also	also	RB
cord-259347-3acsko74	91	8	called	call	VBN
cord-259347-3acsko74	91	9	L	L	NNP
cord-259347-3acsko74	91	10	-	-	HYPH
cord-259347-3acsko74	91	11	SIGN	SIGN	NNP
cord-259347-3acsko74	91	12	)	)	-RRB-
cord-259347-3acsko74	91	13	has	have	VBZ
cord-259347-3acsko74	91	14	also	also	RB
cord-259347-3acsko74	91	15	been	be	VBN
cord-259347-3acsko74	91	16	identified	identify	VBN
cord-259347-3acsko74	91	17	as	as	IN
cord-259347-3acsko74	91	18	an	an	DT
cord-259347-3acsko74	91	19	alternative	alternative	JJ
cord-259347-3acsko74	91	20	cellular	cellular	JJ
cord-259347-3acsko74	91	21	receptor	receptor	NN
cord-259347-3acsko74	91	22	for	for	IN
cord-259347-3acsko74	91	23	SARS	SARS	NNP
cord-259347-3acsko74	91	24	-	-	HYPH
cord-259347-3acsko74	91	25	CoV	CoV	NNP
cord-259347-3acsko74	91	26	[	[	-LRB-
cord-259347-3acsko74	91	27	52	52	CD
cord-259347-3acsko74	91	28	]	]	-RRB-
cord-259347-3acsko74	91	29	.	.	.
cord-259347-3acsko74	92	1	In	in	IN
cord-259347-3acsko74	92	2	addition	addition	NN
cord-259347-3acsko74	92	3	,	,	,
cord-259347-3acsko74	92	4	the	the	DT
cord-259347-3acsko74	92	5	infection	infection	NN
cord-259347-3acsko74	92	6	of	of	IN
cord-259347-3acsko74	92	7	SARS	SARS	NNP
cord-259347-3acsko74	92	8	-	-	HYPH
cord-259347-3acsko74	92	9	CoV	CoV	NNP
cord-259347-3acsko74	92	10	on	on	IN
cord-259347-3acsko74	92	11	ACE2-expressing	ace2-expresse	VBG
cord-259347-3acsko74	92	12	cells	cell	NNS
cord-259347-3acsko74	92	13	seemed	seem	VBD
cord-259347-3acsko74	92	14	to	to	TO
cord-259347-3acsko74	92	15	be	be	VB
cord-259347-3acsko74	92	16	dependent	dependent	JJ
cord-259347-3acsko74	92	17	on	on	IN
cord-259347-3acsko74	92	18	a	a	DT
cord-259347-3acsko74	92	19	proteolytic	proteolytic	JJ
cord-259347-3acsko74	92	20	enzyme	enzyme	NN
cord-259347-3acsko74	92	21	Cathepsin	Cathepsin	NNP
cord-259347-3acsko74	92	22	L	L	NNP
cord-259347-3acsko74	92	23	(	(	-LRB-
cord-259347-3acsko74	92	24	CTSL1	CTSL1	MD
cord-259347-3acsko74	92	25	)	)	-RRB-
cord-259347-3acsko74	92	26	in	in	IN
cord-259347-3acsko74	92	27	a	a	DT
cord-259347-3acsko74	92	28	pH	pH	NNP
cord-259347-3acsko74	92	29	sensitive	sensitive	JJ
cord-259347-3acsko74	92	30	manner	manner	NN
cord-259347-3acsko74	92	31	[	[	-LRB-
cord-259347-3acsko74	92	32	53	53	CD
cord-259347-3acsko74	92	33	,	,	,
cord-259347-3acsko74	92	34	54	54	CD
cord-259347-3acsko74	92	35	]	]	-RRB-
cord-259347-3acsko74	92	36	.	.	.
cord-259347-3acsko74	93	1	The	the	DT
cord-259347-3acsko74	93	2	expression	expression	NN
cord-259347-3acsko74	93	3	levels	level	NNS
cord-259347-3acsko74	93	4	of	of	IN
cord-259347-3acsko74	93	5	these	these	DT
cord-259347-3acsko74	93	6	receptors	receptor	NNS
cord-259347-3acsko74	93	7	in	in	IN
cord-259347-3acsko74	93	8	human	human	JJ
cord-259347-3acsko74	93	9	brain	brain	NN
cord-259347-3acsko74	93	10	,	,	,
cord-259347-3acsko74	93	11	however	however	RB
cord-259347-3acsko74	93	12	,	,	,
cord-259347-3acsko74	93	13	require	require	VBP
cord-259347-3acsko74	93	14	further	further	JJ
cord-259347-3acsko74	93	15	elucidation	elucidation	NN
cord-259347-3acsko74	93	16	to	to	TO
cord-259347-3acsko74	93	17	determine	determine	VB
cord-259347-3acsko74	93	18	the	the	DT
cord-259347-3acsko74	93	19	extent	extent	NN
cord-259347-3acsko74	93	20	to	to	TO
cord-259347-3acsko74	93	21	which	which	WDT
cord-259347-3acsko74	93	22	they	-PRON-	PRP
cord-259347-3acsko74	93	23	may	may	MD
cord-259347-3acsko74	93	24	be	be	VB
cord-259347-3acsko74	93	25	responsible	responsible	JJ
cord-259347-3acsko74	93	26	for	for	IN
cord-259347-3acsko74	93	27	the	the	DT
cord-259347-3acsko74	93	28	hCoVs	hCoVs	NNP
cord-259347-3acsko74	93	29	infection	infection	NN
cord-259347-3acsko74	93	30	in	in	IN
cord-259347-3acsko74	93	31	the	the	DT
cord-259347-3acsko74	93	32	CNS	CNS	NNP
cord-259347-3acsko74	93	33	.	.	.
cord-259347-3acsko74	94	1	In	in	IN
cord-259347-3acsko74	94	2	addition	addition	NN
cord-259347-3acsko74	94	3	to	to	IN
cord-259347-3acsko74	94	4	known	known	JJ
cord-259347-3acsko74	94	5	and	and	CC
cord-259347-3acsko74	94	6	putative	putative	JJ
cord-259347-3acsko74	94	7	receptors	receptor	NNS
cord-259347-3acsko74	94	8	,	,	,
cord-259347-3acsko74	94	9	antibody	antibody	NN
cord-259347-3acsko74	94	10	-	-	HYPH
cord-259347-3acsko74	94	11	dependent	dependent	JJ
cord-259347-3acsko74	94	12	enhancement	enhancement	NN
cord-259347-3acsko74	94	13	(	(	-LRB-
cord-259347-3acsko74	94	14	ADE	ADE	NNP
cord-259347-3acsko74	94	15	)	)	-RRB-
cord-259347-3acsko74	94	16	of	of	IN
cord-259347-3acsko74	94	17	viral	viral	JJ
cord-259347-3acsko74	94	18	entry	entry	NN
cord-259347-3acsko74	94	19	using	use	VBG
cord-259347-3acsko74	94	20	the	the	DT
cord-259347-3acsko74	94	21	fusogenic	fusogenic	JJ
cord-259347-3acsko74	94	22	spike	spike	NN
cord-259347-3acsko74	94	23	protein	protein	NN
cord-259347-3acsko74	94	24	has	have	VBZ
cord-259347-3acsko74	94	25	also	also	RB
cord-259347-3acsko74	94	26	been	be	VBN
cord-259347-3acsko74	94	27	reported	report	VBN
cord-259347-3acsko74	94	28	as	as	IN
cord-259347-3acsko74	94	29	a	a	DT
cord-259347-3acsko74	94	30	pathway	pathway	NN
cord-259347-3acsko74	94	31	to	to	TO
cord-259347-3acsko74	94	32	transfer	transfer	VB
cord-259347-3acsko74	94	33	coronavirus	coronavirus	NN
cord-259347-3acsko74	94	34	(	(	-LRB-
cord-259347-3acsko74	94	35	MHV4	MHV4	NNP
cord-259347-3acsko74	94	36	)	)	-RRB-
cord-259347-3acsko74	94	37	from	from	IN
cord-259347-3acsko74	94	38	infected	infected	JJ
cord-259347-3acsko74	94	39	cells	cell	NNS
cord-259347-3acsko74	94	40	to	to	IN
cord-259347-3acsko74	94	41	non	non	JJ
cord-259347-3acsko74	94	42	-	-	JJ
cord-259347-3acsko74	94	43	infected	infected	JJ
cord-259347-3acsko74	94	44	cells	cell	NNS
cord-259347-3acsko74	94	45	[	[	-LRB-
cord-259347-3acsko74	94	46	55	55	CD
cord-259347-3acsko74	94	47	]	]	-RRB-
cord-259347-3acsko74	94	48	.	.	.
cord-259347-3acsko74	95	1	In	in	IN
cord-259347-3acsko74	95	2	vitro	vitro	FW
cord-259347-3acsko74	95	3	studies	study	NNS
cord-259347-3acsko74	95	4	have	have	VBP
cord-259347-3acsko74	95	5	shown	show	VBN
cord-259347-3acsko74	95	6	that	that	IN
cord-259347-3acsko74	95	7	coronavirus	coronavirus	NN
cord-259347-3acsko74	95	8	entry	entry	NN
cord-259347-3acsko74	95	9	could	could	MD
cord-259347-3acsko74	95	10	be	be	VB
cord-259347-3acsko74	95	11	mediated	mediate	VBN
cord-259347-3acsko74	95	12	by	by	IN
cord-259347-3acsko74	95	13	special	special	JJ
cord-259347-3acsko74	95	14	antibodies	antibody	NNS
cord-259347-3acsko74	95	15	that	that	WDT
cord-259347-3acsko74	95	16	bind	bind	VBP
cord-259347-3acsko74	95	17	the	the	DT
cord-259347-3acsko74	95	18	virus	virus	NN
cord-259347-3acsko74	95	19	surface	surface	NN
cord-259347-3acsko74	95	20	spike	spike	NN
cord-259347-3acsko74	95	21	protein	protein	NN
cord-259347-3acsko74	95	22	and	and	CC
cord-259347-3acsko74	95	23	facilitate	facilitate	VB
cord-259347-3acsko74	95	24	subsequence	subsequence	NN
cord-259347-3acsko74	95	25	viral	viral	JJ
cord-259347-3acsko74	95	26	entry	entry	NN
cord-259347-3acsko74	95	27	of	of	IN
cord-259347-3acsko74	95	28	MERS	MERS	NNP
cord-259347-3acsko74	95	29	-	-	HYPH
cord-259347-3acsko74	95	30	CoV	CoV	NNP
cord-259347-3acsko74	95	31	[	[	-LRB-
cord-259347-3acsko74	95	32	56	56	CD
cord-259347-3acsko74	95	33	]	]	-RRB-
cord-259347-3acsko74	95	34	and	and	CC
cord-259347-3acsko74	95	35	SARS	SARS	NNP
cord-259347-3acsko74	95	36	-	-	HYPH
cord-259347-3acsko74	95	37	CoV	CoV	NNP
cord-259347-3acsko74	95	38	[	[	-LRB-
cord-259347-3acsko74	95	39	57	57	CD
cord-259347-3acsko74	95	40	]	]	-RRB-
cord-259347-3acsko74	95	41	in	in	IN
cord-259347-3acsko74	95	42	a	a	DT
cord-259347-3acsko74	95	43	receptor	receptor	NN
cord-259347-3acsko74	95	44	-	-	HYPH
cord-259347-3acsko74	95	45	like	like	JJ
cord-259347-3acsko74	95	46	manner	manner	NN
cord-259347-3acsko74	95	47	.	.	.
cord-259347-3acsko74	96	1	The	the	DT
cord-259347-3acsko74	96	2	ADE	ADE	NNP
cord-259347-3acsko74	96	3	pathway	pathway	NN
cord-259347-3acsko74	96	4	is	be	VBZ
cord-259347-3acsko74	96	5	particularly	particularly	RB
cord-259347-3acsko74	96	6	important	important	JJ
cord-259347-3acsko74	96	7	for	for	IN
cord-259347-3acsko74	96	8	vaccine	vaccine	NN
cord-259347-3acsko74	96	9	design	design	NN
cord-259347-3acsko74	96	10	and	and	CC
cord-259347-3acsko74	96	11	the	the	DT
cord-259347-3acsko74	96	12	development	development	NN
cord-259347-3acsko74	96	13	of	of	IN
cord-259347-3acsko74	96	14	antibody	antibody	NN
cord-259347-3acsko74	96	15	-	-	HYPH
cord-259347-3acsko74	96	16	based	base	VBN
cord-259347-3acsko74	96	17	drug	drug	NN
cord-259347-3acsko74	96	18	therapies	therapy	NNS
cord-259347-3acsko74	96	19	.	.	.
cord-259347-3acsko74	97	1	6	6	LS
cord-259347-3acsko74	97	2	.	.	.
cord-259347-3acsko74	98	1	Is	be	VBZ
cord-259347-3acsko74	98	2	SARS	SARS	NNP
cord-259347-3acsko74	98	3	-	-	:
cord-259347-3acsko74	98	4	CoV-2	CoV-2	NNP
cord-259347-3acsko74	98	5	likely	likely	JJ
cord-259347-3acsko74	98	6	to	to	TO
cord-259347-3acsko74	98	7	be	be	VB
cord-259347-3acsko74	98	8	present	present	JJ
cord-259347-3acsko74	98	9	in	in	IN
cord-259347-3acsko74	98	10	the	the	DT
cord-259347-3acsko74	98	11	central	central	JJ
cord-259347-3acsko74	98	12	nervous	nervous	JJ
cord-259347-3acsko74	98	13	system	system	NN
cord-259347-3acsko74	98	14	?	?	.
cord-259347-3acsko74	99	1	At	at	IN
cord-259347-3acsko74	99	2	present	present	NN
cord-259347-3acsko74	99	3	,	,	,
cord-259347-3acsko74	99	4	it	-PRON-	PRP
cord-259347-3acsko74	99	5	remains	remain	VBZ
cord-259347-3acsko74	99	6	unknown	unknown	JJ
cord-259347-3acsko74	99	7	whether	whether	IN
cord-259347-3acsko74	99	8	SARS	SARS	NNP
cord-259347-3acsko74	99	9	-	-	HYPH
cord-259347-3acsko74	99	10	CoV-2	CoV-2	NNP
cord-259347-3acsko74	99	11	is	be	VBZ
cord-259347-3acsko74	99	12	present	present	JJ
cord-259347-3acsko74	99	13	in	in	IN
cord-259347-3acsko74	99	14	the	the	DT
cord-259347-3acsko74	99	15	CNS	CNS	NNP
cord-259347-3acsko74	99	16	,	,	,
cord-259347-3acsko74	99	17	possibly	possibly	RB
cord-259347-3acsko74	99	18	due	due	JJ
cord-259347-3acsko74	99	19	to	to	IN
cord-259347-3acsko74	99	20	limited	limited	JJ
cord-259347-3acsko74	99	21	access	access	NN
cord-259347-3acsko74	99	22	to	to	IN
cord-259347-3acsko74	99	23	brain	brain	NN
cord-259347-3acsko74	99	24	tissue	tissue	NN
cord-259347-3acsko74	99	25	and	and	CC
cord-259347-3acsko74	99	26	CSF	csf	NN
cord-259347-3acsko74	99	27	from	from	IN
cord-259347-3acsko74	99	28	patients	patient	NNS
cord-259347-3acsko74	99	29	infected	infect	VBN
cord-259347-3acsko74	99	30	with	with	IN
cord-259347-3acsko74	99	31	the	the	DT
cord-259347-3acsko74	99	32	virus	virus	NN
cord-259347-3acsko74	99	33	.	.	.
cord-259347-3acsko74	100	1	Autopsies	autopsy	NNS
cord-259347-3acsko74	100	2	are	be	VBP
cord-259347-3acsko74	100	3	being	be	VBG
cord-259347-3acsko74	100	4	increasingly	increasingly	RB
cord-259347-3acsko74	100	5	carried	carry	VBN
cord-259347-3acsko74	100	6	out	out	RP
cord-259347-3acsko74	100	7	,	,	,
cord-259347-3acsko74	100	8	however	however	RB
cord-259347-3acsko74	100	9	,	,	,
cord-259347-3acsko74	100	10	initial	initial	JJ
cord-259347-3acsko74	100	11	biopsies	biopsy	NNS
cord-259347-3acsko74	100	12	have	have	VBP
cord-259347-3acsko74	100	13	been	be	VBN
cord-259347-3acsko74	100	14	taken	take	VBN
cord-259347-3acsko74	100	15	only	only	RB
cord-259347-3acsko74	100	16	from	from	IN
cord-259347-3acsko74	100	17	lung	lung	NN
cord-259347-3acsko74	100	18	,	,	,
cord-259347-3acsko74	100	19	liver	liver	NN
cord-259347-3acsko74	100	20	and	and	CC
cord-259347-3acsko74	100	21	heart	heart	NN
cord-259347-3acsko74	100	22	for	for	IN
cord-259347-3acsko74	100	23	histopathology	histopathology	NN
cord-259347-3acsko74	100	24	[	[	-LRB-
cord-259347-3acsko74	100	25	58	58	CD
cord-259347-3acsko74	100	26	]	]	-RRB-
cord-259347-3acsko74	100	27	.	.	.
cord-259347-3acsko74	101	1	Given	give	VBN
cord-259347-3acsko74	101	2	that	that	IN
cord-259347-3acsko74	101	3	several	several	JJ
cord-259347-3acsko74	101	4	strains	strain	NNS
cord-259347-3acsko74	101	5	of	of	IN
cord-259347-3acsko74	101	6	hCoVs	hCoVs	NNP
cord-259347-3acsko74	101	7	have	have	VBP
cord-259347-3acsko74	101	8	been	be	VBN
cord-259347-3acsko74	101	9	shown	show	VBN
cord-259347-3acsko74	101	10	to	to	TO
cord-259347-3acsko74	101	11	be	be	VB
cord-259347-3acsko74	101	12	present	present	JJ
cord-259347-3acsko74	101	13	in	in	IN
cord-259347-3acsko74	101	14	the	the	DT
cord-259347-3acsko74	101	15	brain	brain	NN
cord-259347-3acsko74	101	16	,	,	,
cord-259347-3acsko74	101	17	as	as	RB
cord-259347-3acsko74	101	18	well	well	RB
cord-259347-3acsko74	101	19	as	as	IN
cord-259347-3acsko74	101	20	CSF	CSF	NNP
cord-259347-3acsko74	101	21	[	[	-LRB-
cord-259347-3acsko74	101	22	14À16,26À30	14à16,26à30	CD
cord-259347-3acsko74	101	23	]	]	-RRB-
cord-259347-3acsko74	101	24	,	,	,
cord-259347-3acsko74	101	25	with	with	IN
cord-259347-3acsko74	101	26	neuroinvasion	neuroinvasion	NN
cord-259347-3acsko74	101	27	and	and	CC
cord-259347-3acsko74	101	28	neurovirulence	neurovirulence	NN
cord-259347-3acsko74	101	29	shown	show	VBN
cord-259347-3acsko74	101	30	in	in	IN
cord-259347-3acsko74	101	31	cell	cell	NN
cord-259347-3acsko74	101	32	culture	culture	NN
cord-259347-3acsko74	101	33	and	and	CC
cord-259347-3acsko74	101	34	animal	animal	NN
cord-259347-3acsko74	101	35	models	model	NNS
cord-259347-3acsko74	101	36	[	[	-LRB-
cord-259347-3acsko74	101	37	4,5,11À13,17À25	4,5,11à13,17à25	CD
cord-259347-3acsko74	101	38	]	]	-RRB-
cord-259347-3acsko74	101	39	,	,	,
cord-259347-3acsko74	101	40	it	-PRON-	PRP
cord-259347-3acsko74	101	41	is	be	VBZ
cord-259347-3acsko74	101	42	reasonable	reasonable	JJ
cord-259347-3acsko74	101	43	to	to	TO
cord-259347-3acsko74	101	44	consider	consider	VB
cord-259347-3acsko74	101	45	that	that	IN
cord-259347-3acsko74	101	46	the	the	DT
cord-259347-3acsko74	101	47	SARS	SARS	NNP
cord-259347-3acsko74	101	48	-	-	HYPH
cord-259347-3acsko74	101	49	CoV-2	CoV-2	NNP
cord-259347-3acsko74	101	50	may	may	MD
cord-259347-3acsko74	101	51	also	also	RB
cord-259347-3acsko74	101	52	be	be	VB
cord-259347-3acsko74	101	53	present	present	JJ
cord-259347-3acsko74	101	54	in	in	IN
cord-259347-3acsko74	101	55	the	the	DT
cord-259347-3acsko74	101	56	CNS	CNS	NNP
cord-259347-3acsko74	101	57	.	.	.
cord-259347-3acsko74	102	1	This	this	DT
cord-259347-3acsko74	102	2	is	be	VBZ
cord-259347-3acsko74	102	3	further	further	RB
cord-259347-3acsko74	102	4	supported	support	VBN
cord-259347-3acsko74	102	5	by	by	IN
cord-259347-3acsko74	102	6	the	the	DT
cord-259347-3acsko74	102	7	fact	fact	NN
cord-259347-3acsko74	102	8	that	that	IN
cord-259347-3acsko74	102	9	some	some	DT
cord-259347-3acsko74	102	10	COVID-19	covid-19	CD
cord-259347-3acsko74	102	11	patients	patient	NNS
cord-259347-3acsko74	102	12	present	present	JJ
cord-259347-3acsko74	102	13	with	with	IN
cord-259347-3acsko74	102	14	headache	headache	NN
cord-259347-3acsko74	102	15	,	,	,
cord-259347-3acsko74	102	16	nausea	nausea	NN
cord-259347-3acsko74	102	17	and	and	CC
cord-259347-3acsko74	102	18	vomiting	vomiting	NN
cord-259347-3acsko74	102	19	,	,	,
cord-259347-3acsko74	102	20	symptoms	symptom	NNS
cord-259347-3acsko74	102	21	that	that	WDT
cord-259347-3acsko74	102	22	potentially	potentially	RB
cord-259347-3acsko74	102	23	indicates	indicate	VBZ
cord-259347-3acsko74	102	24	neurological	neurological	JJ
cord-259347-3acsko74	102	25	involvement	involvement	NN
cord-259347-3acsko74	102	26	[	[	-LRB-
cord-259347-3acsko74	102	27	59	59	CD
cord-259347-3acsko74	102	28	]	]	-RRB-
cord-259347-3acsko74	102	29	.	.	.
cord-259347-3acsko74	103	1	The	the	DT
cord-259347-3acsko74	103	2	frequency	frequency	NN
cord-259347-3acsko74	103	3	of	of	IN
cord-259347-3acsko74	103	4	neurological	neurological	JJ
cord-259347-3acsko74	103	5	manifestations	manifestation	NNS
cord-259347-3acsko74	103	6	including	include	VBG
cord-259347-3acsko74	103	7	changes	change	NNS
cord-259347-3acsko74	103	8	in	in	IN
cord-259347-3acsko74	103	9	consciousness	consciousness	NN
cord-259347-3acsko74	103	10	and	and	CC
cord-259347-3acsko74	103	11	acute	acute	JJ
cord-259347-3acsko74	103	12	cerebrovascular	cerebrovascular	JJ
cord-259347-3acsko74	103	13	disease	disease	NN
cord-259347-3acsko74	103	14	increase	increase	NN
cord-259347-3acsko74	103	15	in	in	IN
cord-259347-3acsko74	103	16	parallel	parallel	NN
cord-259347-3acsko74	103	17	with	with	IN
cord-259347-3acsko74	103	18	the	the	DT
cord-259347-3acsko74	103	19	severity	severity	NN
cord-259347-3acsko74	103	20	of	of	IN
cord-259347-3acsko74	103	21	the	the	DT
cord-259347-3acsko74	103	22	disease	disease	NN
cord-259347-3acsko74	103	23	[	[	-LRB-
cord-259347-3acsko74	103	24	60	60	CD
cord-259347-3acsko74	103	25	]	]	-RRB-
cord-259347-3acsko74	103	26	.	.	.
cord-259347-3acsko74	104	1	One	one	CD
cord-259347-3acsko74	104	2	study	study	NN
cord-259347-3acsko74	104	3	on	on	IN
cord-259347-3acsko74	104	4	nasal	nasal	JJ
cord-259347-3acsko74	104	5	epithelium	epithelium	NN
cord-259347-3acsko74	104	6	samples	sample	NNS
cord-259347-3acsko74	104	7	taken	take	VBN
cord-259347-3acsko74	104	8	from	from	IN
cord-259347-3acsko74	104	9	a	a	DT
cord-259347-3acsko74	104	10	subset	subset	NN
cord-259347-3acsko74	104	11	of	of	IN
cord-259347-3acsko74	104	12	COVID-19	covid-19	JJ
cord-259347-3acsko74	104	13	patients	patient	NNS
cord-259347-3acsko74	104	14	exhibiting	exhibit	VBG
cord-259347-3acsko74	104	15	olfactory	olfactory	JJ
cord-259347-3acsko74	104	16	dysfunction	dysfunction	NN
cord-259347-3acsko74	104	17	has	have	VBZ
cord-259347-3acsko74	104	18	suggested	suggest	VBN
cord-259347-3acsko74	104	19	that	that	IN
cord-259347-3acsko74	104	20	the	the	DT
cord-259347-3acsko74	104	21	disturbance	disturbance	NN
cord-259347-3acsko74	104	22	of	of	IN
cord-259347-3acsko74	104	23	smell	smell	NN
cord-259347-3acsko74	104	24	in	in	IN
cord-259347-3acsko74	104	25	these	these	DT
cord-259347-3acsko74	104	26	patients	patient	NNS
cord-259347-3acsko74	104	27	is	be	VBZ
cord-259347-3acsko74	104	28	more	more	RBR
cord-259347-3acsko74	104	29	possibly	possibly	RB
cord-259347-3acsko74	104	30	due	due	JJ
cord-259347-3acsko74	104	31	to	to	IN
cord-259347-3acsko74	104	32	SARS	SARS	NNP
cord-259347-3acsko74	104	33	-	-	HYPH
cord-259347-3acsko74	104	34	CoV-2	CoV-2	NNP
cord-259347-3acsko74	104	35	infection	infection	NN
cord-259347-3acsko74	104	36	of	of	IN
cord-259347-3acsko74	104	37	non	non	JJ
cord-259347-3acsko74	104	38	-	-	JJ
cord-259347-3acsko74	104	39	neuronal	neuronal	JJ
cord-259347-3acsko74	104	40	cells	cell	NNS
cord-259347-3acsko74	104	41	rather	rather	RB
cord-259347-3acsko74	104	42	than	than	IN
cord-259347-3acsko74	104	43	olfactory	olfactory	JJ
cord-259347-3acsko74	104	44	neurons	neuron	NNS
cord-259347-3acsko74	104	45	[	[	-LRB-
cord-259347-3acsko74	104	46	63	63	CD
cord-259347-3acsko74	104	47	]	]	-RRB-
cord-259347-3acsko74	104	48	.	.	.
cord-259347-3acsko74	105	1	More	more	RBR
cord-259347-3acsko74	105	2	recently	recently	RB
cord-259347-3acsko74	105	3	,	,	,
cord-259347-3acsko74	105	4	the	the	DT
cord-259347-3acsko74	105	5	report	report	NN
cord-259347-3acsko74	105	6	of	of	IN
cord-259347-3acsko74	105	7	a	a	DT
cord-259347-3acsko74	105	8	cohort	cohort	NN
cord-259347-3acsko74	105	9	of	of	IN
cord-259347-3acsko74	105	10	58	58	CD
cord-259347-3acsko74	105	11	COVID-19	covid-19	CD
cord-259347-3acsko74	105	12	patients	patient	NNS
cord-259347-3acsko74	105	13	showed	show	VBD
cord-259347-3acsko74	105	14	a	a	DT
cord-259347-3acsko74	105	15	correlation	correlation	NN
cord-259347-3acsko74	105	16	between	between	IN
cord-259347-3acsko74	105	17	acute	acute	JJ
cord-259347-3acsko74	105	18	respiratory	respiratory	JJ
cord-259347-3acsko74	105	19	distress	distress	NN
cord-259347-3acsko74	105	20	syndrome	syndrome	NN
cord-259347-3acsko74	105	21	(	(	-LRB-
cord-259347-3acsko74	105	22	ARDS	ARDS	NNP
cord-259347-3acsko74	105	23	)	)	-RRB-
cord-259347-3acsko74	105	24	and	and	CC
cord-259347-3acsko74	105	25	encephalopathy	encephalopathy	NN
cord-259347-3acsko74	105	26	,	,	,
cord-259347-3acsko74	105	27	mainly	mainly	RB
cord-259347-3acsko74	105	28	agitation	agitation	NN
cord-259347-3acsko74	105	29	,	,	,
cord-259347-3acsko74	105	30	confusion	confusion	NN
cord-259347-3acsko74	105	31	and	and	CC
cord-259347-3acsko74	105	32	corticospinal	corticospinal	JJ
cord-259347-3acsko74	105	33	tract	tract	NN
cord-259347-3acsko74	105	34	signs	sign	NNS
cord-259347-3acsko74	105	35	[	[	-LRB-
cord-259347-3acsko74	105	36	61	61	CD
cord-259347-3acsko74	105	37	]	]	-RRB-
cord-259347-3acsko74	105	38	.	.	.
cord-259347-3acsko74	106	1	However	however	RB
cord-259347-3acsko74	106	2	,	,	,
cord-259347-3acsko74	106	3	these	these	DT
cord-259347-3acsko74	106	4	findings	finding	NNS
cord-259347-3acsko74	106	5	need	need	VBP
cord-259347-3acsko74	106	6	to	to	TO
cord-259347-3acsko74	106	7	be	be	VB
cord-259347-3acsko74	106	8	confirmed	confirm	VBN
cord-259347-3acsko74	106	9	by	by	IN
cord-259347-3acsko74	106	10	studies	study	NNS
cord-259347-3acsko74	106	11	on	on	IN
cord-259347-3acsko74	106	12	brain	brain	NN
cord-259347-3acsko74	106	13	samples	sample	NNS
cord-259347-3acsko74	106	14	or	or	CC
cord-259347-3acsko74	106	15	CSF	CSF	NNP
cord-259347-3acsko74	106	16	.	.	.
cord-259347-3acsko74	107	1	The	the	DT
cord-259347-3acsko74	107	2	most	most	RBS
cord-259347-3acsko74	107	3	efficient	efficient	JJ
cord-259347-3acsko74	107	4	way	way	NN
cord-259347-3acsko74	107	5	to	to	TO
cord-259347-3acsko74	107	6	identify	identify	VB
cord-259347-3acsko74	107	7	involvement	involvement	NN
cord-259347-3acsko74	107	8	of	of	IN
cord-259347-3acsko74	107	9	neurological	neurological	JJ
cord-259347-3acsko74	107	10	systems	system	NNS
cord-259347-3acsko74	107	11	remains	remain	VBZ
cord-259347-3acsko74	107	12	to	to	TO
cord-259347-3acsko74	107	13	be	be	VB
cord-259347-3acsko74	107	14	determined	determine	VBN
cord-259347-3acsko74	107	15	.	.	.
cord-259347-3acsko74	108	1	The	the	DT
cord-259347-3acsko74	108	2	presence	presence	NN
cord-259347-3acsko74	108	3	of	of	IN
cord-259347-3acsko74	108	4	SARS	SARS	NNP
cord-259347-3acsko74	108	5	-	-	HYPH
cord-259347-3acsko74	108	6	CoV-2	CoV-2	NNP
cord-259347-3acsko74	108	7	in	in	IN
cord-259347-3acsko74	108	8	CSF	CSF	NNP
cord-259347-3acsko74	108	9	was	be	VBD
cord-259347-3acsko74	108	10	confirmed	confirm	VBN
cord-259347-3acsko74	108	11	by	by	IN
cord-259347-3acsko74	108	12	gene	gene	NN
cord-259347-3acsko74	108	13	sequencing	sequencing	NN
cord-259347-3acsko74	108	14	in	in	IN
cord-259347-3acsko74	108	15	a	a	DT
cord-259347-3acsko74	108	16	56-year	56-year	JJ
cord-259347-3acsko74	108	17	-	-	HYPH
cord-259347-3acsko74	108	18	old	old	JJ
cord-259347-3acsko74	108	19	patient	patient	NN
cord-259347-3acsko74	108	20	with	with	IN
cord-259347-3acsko74	108	21	COVID-19	COVID-19	NNP
cord-259347-3acsko74	108	22	,	,	,
cord-259347-3acsko74	108	23	which	which	WDT
cord-259347-3acsko74	108	24	was	be	VBD
cord-259347-3acsko74	108	25	the	the	DT
cord-259347-3acsko74	108	26	first	first	JJ
cord-259347-3acsko74	108	27	direct	direct	JJ
cord-259347-3acsko74	108	28	evidence	evidence	NN
cord-259347-3acsko74	108	29	for	for	IN
cord-259347-3acsko74	108	30	the	the	DT
cord-259347-3acsko74	108	31	neuroinvasion	neuroinvasion	NN
cord-259347-3acsko74	108	32	of	of	IN
cord-259347-3acsko74	108	33	this	this	DT
cord-259347-3acsko74	108	34	novel	novel	JJ
cord-259347-3acsko74	108	35	coronavirus	coronavirus	NN
cord-259347-3acsko74	108	36	[	[	-LRB-
cord-259347-3acsko74	108	37	62	62	CD
cord-259347-3acsko74	108	38	]	]	-RRB-
cord-259347-3acsko74	108	39	.	.	.
cord-259347-3acsko74	109	1	Brain	brain	NN
cord-259347-3acsko74	109	2	samples	sample	NNS
cord-259347-3acsko74	109	3	remain	remain	VBP
cord-259347-3acsko74	109	4	the	the	DT
cord-259347-3acsko74	109	5	gold	gold	NN
cord-259347-3acsko74	109	6	standard	standard	NN
cord-259347-3acsko74	109	7	of	of	IN
cord-259347-3acsko74	109	8	confirmation	confirmation	NN
cord-259347-3acsko74	109	9	,	,	,
cord-259347-3acsko74	109	10	however	however	RB
cord-259347-3acsko74	109	11	,	,	,
cord-259347-3acsko74	109	12	access	access	VBP
cord-259347-3acsko74	109	13	to	to	IN
cord-259347-3acsko74	109	14	such	such	JJ
cord-259347-3acsko74	109	15	samples	sample	NNS
cord-259347-3acsko74	109	16	will	will	MD
cord-259347-3acsko74	109	17	almost	almost	RB
cord-259347-3acsko74	109	18	certainly	certainly	RB
cord-259347-3acsko74	109	19	remain	remain	VB
cord-259347-3acsko74	109	20	very	very	RB
cord-259347-3acsko74	109	21	limited	limited	JJ
cord-259347-3acsko74	109	22	and	and	CC
cord-259347-3acsko74	109	23	it	-PRON-	PRP
cord-259347-3acsko74	109	24	is	be	VBZ
cord-259347-3acsko74	109	25	not	not	RB
cord-259347-3acsko74	109	26	a	a	DT
cord-259347-3acsko74	109	27	practical	practical	JJ
cord-259347-3acsko74	109	28	or	or	CC
cord-259347-3acsko74	109	29	ethical	ethical	JJ
cord-259347-3acsko74	109	30	consideration	consideration	NN
cord-259347-3acsko74	109	31	in	in	IN
cord-259347-3acsko74	109	32	larger	large	JJR
cord-259347-3acsko74	109	33	cohorts	cohort	NNS
cord-259347-3acsko74	109	34	,	,	,
cord-259347-3acsko74	109	35	especially	especially	RB
cord-259347-3acsko74	109	36	in	in	IN
cord-259347-3acsko74	109	37	mild	mild	JJ
cord-259347-3acsko74	109	38	to	to	IN
cord-259347-3acsko74	109	39	moderate	moderate	JJ
cord-259347-3acsko74	109	40	cases	case	NNS
cord-259347-3acsko74	109	41	.	.	.
cord-259347-3acsko74	110	1	Several	several	JJ
cord-259347-3acsko74	110	2	pathways	pathway	NNS
cord-259347-3acsko74	110	3	of	of	IN
cord-259347-3acsko74	110	4	invasion	invasion	NN
cord-259347-3acsko74	110	5	for	for	IN
cord-259347-3acsko74	110	6	hCoVs	hCoVs	NNP
cord-259347-3acsko74	110	7	have	have	VBP
cord-259347-3acsko74	110	8	been	be	VBN
cord-259347-3acsko74	110	9	proposed	propose	VBN
cord-259347-3acsko74	110	10	,	,	,
cord-259347-3acsko74	110	11	including	include	VBG
cord-259347-3acsko74	110	12	via	via	IN
cord-259347-3acsko74	110	13	the	the	DT
cord-259347-3acsko74	110	14	olfactory	olfactory	JJ
cord-259347-3acsko74	110	15	nerve	nerve	NN
cord-259347-3acsko74	110	16	,	,	,
cord-259347-3acsko74	110	17	neurotransmitter	neurotransmitter	NN
cord-259347-3acsko74	110	18	pathways	pathway	NNS
cord-259347-3acsko74	110	19	,	,	,
cord-259347-3acsko74	110	20	hematogenous	hematogenous	NNP
cord-259347-3acsko74	110	21	route	route	NN
cord-259347-3acsko74	110	22	,	,	,
cord-259347-3acsko74	110	23	Virchow	Virchow	NNP
cord-259347-3acsko74	110	24	-	-	HYPH
cord-259347-3acsko74	110	25	Robin	Robin	NNP
cord-259347-3acsko74	110	26	space	space	NN
cord-259347-3acsko74	110	27	surrounding	surround	VBG
cord-259347-3acsko74	110	28	arterioles	arteriole	NNS
cord-259347-3acsko74	110	29	and	and	CC
cord-259347-3acsko74	110	30	venules	venule	NNS
cord-259347-3acsko74	110	31	,	,	,
cord-259347-3acsko74	110	32	lymphatic	lymphatic	JJ
cord-259347-3acsko74	110	33	systems	system	NNS
cord-259347-3acsko74	110	34	and	and	CC
cord-259347-3acsko74	110	35	receptors	receptor	NNS
cord-259347-3acsko74	110	36	,	,	,
cord-259347-3acsko74	110	37	from	from	IN
cord-259347-3acsko74	110	38	which	which	WDT
cord-259347-3acsko74	110	39	alternative	alternative	JJ
cord-259347-3acsko74	110	40	parameters	parameter	NNS
cord-259347-3acsko74	110	41	and	and	CC
cord-259347-3acsko74	110	42	types	type	NNS
cord-259347-3acsko74	110	43	of	of	IN
cord-259347-3acsko74	110	44	samples	sample	NNS
cord-259347-3acsko74	110	45	may	may	MD
cord-259347-3acsko74	110	46	offer	offer	VB
cord-259347-3acsko74	110	47	opportunity	opportunity	NN
cord-259347-3acsko74	110	48	for	for	IN
cord-259347-3acsko74	110	49	proof	proof	NN
cord-259347-3acsko74	110	50	of	of	IN
cord-259347-3acsko74	110	51	CNS	CNS	NNP
cord-259347-3acsko74	110	52	involvement	involvement	NN
cord-259347-3acsko74	110	53	.	.	.
cord-259347-3acsko74	111	1	More	More	JJR
cord-259347-3acsko74	111	2	studies	study	NNS
cord-259347-3acsko74	111	3	are	be	VBP
cord-259347-3acsko74	111	4	needed	need	VBN
cord-259347-3acsko74	111	5	to	to	TO
cord-259347-3acsko74	111	6	evaluate	evaluate	VB
cord-259347-3acsko74	111	7	and	and	CC
cord-259347-3acsko74	111	8	compare	compare	VB
cord-259347-3acsko74	111	9	these	these	DT
cord-259347-3acsko74	111	10	alternative	alternative	JJ
cord-259347-3acsko74	111	11	pathways	pathway	NNS
cord-259347-3acsko74	111	12	and	and	CC
cord-259347-3acsko74	111	13	parameters	parameter	NNS
cord-259347-3acsko74	111	14	.	.	.
cord-259347-3acsko74	112	1	In	in	IN
cord-259347-3acsko74	112	2	addition	addition	NN
cord-259347-3acsko74	112	3	,	,	,
cord-259347-3acsko74	112	4	the	the	DT
cord-259347-3acsko74	112	5	timing	timing	NN
cord-259347-3acsko74	112	6	of	of	IN
cord-259347-3acsko74	112	7	sampling	sampling	NN
cord-259347-3acsko74	112	8	needs	need	NNS
cord-259347-3acsko74	112	9	further	further	JJ
cord-259347-3acsko74	112	10	investigation	investigation	NN
cord-259347-3acsko74	112	11	,	,	,
cord-259347-3acsko74	112	12	as	as	IN
cord-259347-3acsko74	112	13	the	the	DT
cord-259347-3acsko74	112	14	change	change	NN
cord-259347-3acsko74	112	15	of	of	IN
cord-259347-3acsko74	112	16	viral	viral	JJ
cord-259347-3acsko74	112	17	load	load	NN
cord-259347-3acsko74	112	18	in	in	IN
cord-259347-3acsko74	112	19	the	the	DT
cord-259347-3acsko74	112	20	human	human	JJ
cord-259347-3acsko74	112	21	body	body	NN
cord-259347-3acsko74	112	22	at	at	IN
cord-259347-3acsko74	112	23	different	different	JJ
cord-259347-3acsko74	112	24	stages	stage	NNS
cord-259347-3acsko74	112	25	of	of	IN
cord-259347-3acsko74	112	26	COVID-19-related	covid-19-related	JJ
cord-259347-3acsko74	112	27	infection	infection	NN
cord-259347-3acsko74	112	28	and	and	CC
cord-259347-3acsko74	112	29	recovery	recovery	NN
cord-259347-3acsko74	112	30	remains	remain	VBZ
cord-259347-3acsko74	112	31	unclear	unclear	JJ
cord-259347-3acsko74	112	32	.	.	.
cord-259347-3acsko74	113	1	Though	though	IN
cord-259347-3acsko74	113	2	considered	consider	VBN
cord-259347-3acsko74	113	3	mainly	mainly	RB
cord-259347-3acsko74	113	4	as	as	IN
cord-259347-3acsko74	113	5	respiratory	respiratory	JJ
cord-259347-3acsko74	113	6	viruses	virus	NNS
cord-259347-3acsko74	113	7	,	,	,
cord-259347-3acsko74	113	8	several	several	JJ
cord-259347-3acsko74	113	9	strains	strain	NNS
cord-259347-3acsko74	113	10	of	of	IN
cord-259347-3acsko74	113	11	hCoVs	hCoVs	NNP
cord-259347-3acsko74	113	12	have	have	VBP
cord-259347-3acsko74	113	13	been	be	VBN
cord-259347-3acsko74	113	14	detected	detect	VBN
cord-259347-3acsko74	113	15	in	in	IN
cord-259347-3acsko74	113	16	brains	brain	NNS
cord-259347-3acsko74	113	17	from	from	IN
cord-259347-3acsko74	113	18	patients	patient	NNS
cord-259347-3acsko74	113	19	with	with	IN
cord-259347-3acsko74	113	20	encephalitis	encephalitis	NN
cord-259347-3acsko74	113	21	and	and	CC
cord-259347-3acsko74	113	22	multiple	multiple	JJ
cord-259347-3acsko74	113	23	sclerosis	sclerosis	NN
cord-259347-3acsko74	113	24	.	.	.
cord-259347-3acsko74	114	1	In	in	IN
cord-259347-3acsko74	114	2	addition	addition	NN
cord-259347-3acsko74	114	3	,	,	,
cord-259347-3acsko74	114	4	the	the	DT
cord-259347-3acsko74	114	5	detection	detection	NN
cord-259347-3acsko74	114	6	of	of	IN
cord-259347-3acsko74	114	7	SARS	SARS	NNP
cord-259347-3acsko74	114	8	-	-	HYPH
cord-259347-3acsko74	114	9	CoV	CoV	NNP
cord-259347-3acsko74	114	10	in	in	IN
cord-259347-3acsko74	114	11	CSF	CSF	NNP
cord-259347-3acsko74	114	12	of	of	IN
cord-259347-3acsko74	114	13	patients	patient	NNS
cord-259347-3acsko74	114	14	with	with	IN
cord-259347-3acsko74	114	15	neurological	neurological	JJ
cord-259347-3acsko74	114	16	manifestation	manifestation	NN
cord-259347-3acsko74	114	17	has	have	VBZ
cord-259347-3acsko74	114	18	also	also	RB
cord-259347-3acsko74	114	19	provided	provide	VBN
cord-259347-3acsko74	114	20	direct	direct	JJ
cord-259347-3acsko74	114	21	evidence	evidence	NN
cord-259347-3acsko74	114	22	for	for	IN
cord-259347-3acsko74	114	23	the	the	DT
cord-259347-3acsko74	114	24	neuroinvasion	neuroinvasion	NN
cord-259347-3acsko74	114	25	and	and	CC
cord-259347-3acsko74	114	26	neurovirulence	neurovirulence	NN
cord-259347-3acsko74	114	27	of	of	IN
cord-259347-3acsko74	114	28	hCoVs	hCoVs	NNP
cord-259347-3acsko74	114	29	.	.	.
cord-259347-3acsko74	115	1	However	however	RB
cord-259347-3acsko74	115	2	,	,	,
cord-259347-3acsko74	115	3	the	the	DT
cord-259347-3acsko74	115	4	role	role	NN
cord-259347-3acsko74	115	5	of	of	IN
cord-259347-3acsko74	115	6	the	the	DT
cord-259347-3acsko74	115	7	virus	virus	NN
cord-259347-3acsko74	115	8	in	in	IN
cord-259347-3acsko74	115	9	the	the	DT
cord-259347-3acsko74	115	10	process	process	NN
cord-259347-3acsko74	115	11	of	of	IN
cord-259347-3acsko74	115	12	the	the	DT
cord-259347-3acsko74	115	13	disease	disease	NN
cord-259347-3acsko74	115	14	in	in	IN
cord-259347-3acsko74	115	15	acute	acute	JJ
cord-259347-3acsko74	115	16	phase	phase	NN
cord-259347-3acsko74	115	17	as	as	RB
cord-259347-3acsko74	115	18	well	well	RB
cord-259347-3acsko74	115	19	as	as	IN
cord-259347-3acsko74	115	20	in	in	IN
cord-259347-3acsko74	115	21	the	the	DT
cord-259347-3acsko74	115	22	long	long	JJ
cord-259347-3acsko74	115	23	term	term	NN
cord-259347-3acsko74	115	24	still	still	RB
cord-259347-3acsko74	115	25	remains	remain	VBZ
cord-259347-3acsko74	115	26	elusive	elusive	JJ
cord-259347-3acsko74	115	27	.	.	.
cord-259347-3acsko74	116	1	The	the	DT
cord-259347-3acsko74	116	2	current	current	JJ
cord-259347-3acsko74	116	3	strain	strain	NN
cord-259347-3acsko74	117	1	SARS	SARS	NNP
cord-259347-3acsko74	117	2	-	-	HYPH
cord-259347-3acsko74	117	3	CoV-2	CoV-2	NNP
cord-259347-3acsko74	117	4	can	can	MD
cord-259347-3acsko74	117	5	also	also	RB
cord-259347-3acsko74	117	6	potentially	potentially	RB
cord-259347-3acsko74	117	7	infect	infect	VB
cord-259347-3acsko74	117	8	neuronal	neuronal	JJ
cord-259347-3acsko74	117	9	cells	cell	NNS
cord-259347-3acsko74	117	10	in	in	IN
cord-259347-3acsko74	117	11	the	the	DT
cord-259347-3acsko74	117	12	brain	brain	NN
cord-259347-3acsko74	117	13	.	.	.
cord-259347-3acsko74	118	1	Therefore	therefore	RB
cord-259347-3acsko74	118	2	,	,	,
cord-259347-3acsko74	118	3	a	a	DT
cord-259347-3acsko74	118	4	better	well	JJR
cord-259347-3acsko74	118	5	understanding	understanding	NN
cord-259347-3acsko74	118	6	of	of	IN
cord-259347-3acsko74	118	7	dissemination	dissemination	NN
cord-259347-3acsko74	118	8	characteristics	characteristic	NNS
cord-259347-3acsko74	118	9	and	and	CC
cord-259347-3acsko74	118	10	neuropathogenesis	neuropathogenesis	NN
cord-259347-3acsko74	118	11	of	of	IN
cord-259347-3acsko74	118	12	these	these	DT
cord-259347-3acsko74	118	13	hCoVs	hCoVs	NNP
cord-259347-3acsko74	118	14	in	in	IN
cord-259347-3acsko74	118	15	the	the	DT
cord-259347-3acsko74	118	16	CNS	CNS	NNP
cord-259347-3acsko74	118	17	is	be	VBZ
cord-259347-3acsko74	118	18	urgently	urgently	RB
cord-259347-3acsko74	118	19	needed	need	VBN
cord-259347-3acsko74	118	20	.	.	.
cord-259347-3acsko74	119	1	Catching	catch	VBG
cord-259347-3acsko74	119	2	a	a	DT
cord-259347-3acsko74	119	3	viral	viral	JJ
cord-259347-3acsko74	119	4	infection	infection	NN
cord-259347-3acsko74	119	5	with	with	IN
cord-259347-3acsko74	119	6	ensuing	ensue	VBG
cord-259347-3acsko74	119	7	cytokine	cytokine	NN
cord-259347-3acsko74	119	8	release	release	NN
cord-259347-3acsko74	119	9	and	and	CC
cord-259347-3acsko74	119	10	tissue	tissue	NN
cord-259347-3acsko74	119	11	lesions	lesion	NNS
cord-259347-3acsko74	119	12	may	may	MD
cord-259347-3acsko74	119	13	lead	lead	VB
cord-259347-3acsko74	119	14	to	to	IN
cord-259347-3acsko74	119	15	a	a	DT
cord-259347-3acsko74	119	16	variety	variety	NN
cord-259347-3acsko74	119	17	of	of	IN
cord-259347-3acsko74	119	18	CNS	CNS	NNP
cord-259347-3acsko74	119	19	-	-	HYPH
cord-259347-3acsko74	119	20	related	relate	VBN
cord-259347-3acsko74	119	21	manifestations	manifestation	NNS
cord-259347-3acsko74	119	22	(	(	-LRB-
cord-259347-3acsko74	119	23	delirium	delirium	NN
cord-259347-3acsko74	119	24	,	,	,
cord-259347-3acsko74	119	25	headache	headache	NN
cord-259347-3acsko74	119	26	,	,	,
cord-259347-3acsko74	119	27	vomiting	vomiting	NN
cord-259347-3acsko74	119	28	,	,	,
cord-259347-3acsko74	119	29	etc	etc	FW
cord-259347-3acsko74	119	30	.	.	.
cord-259347-3acsko74	119	31	)	)	-RRB-
cord-259347-3acsko74	119	32	,	,	,
cord-259347-3acsko74	119	33	which	which	WDT
cord-259347-3acsko74	119	34	are	be	VBP
cord-259347-3acsko74	119	35	recognizable	recognizable	JJ
cord-259347-3acsko74	119	36	for	for	IN
cord-259347-3acsko74	119	37	many	many	JJ
cord-259347-3acsko74	119	38	viruses	virus	NNS
cord-259347-3acsko74	119	39	including	include	VBG
cord-259347-3acsko74	119	40	hCoVs	hcovs	NN
cord-259347-3acsko74	119	41	,	,	,
cord-259347-3acsko74	119	42	however	however	RB
cord-259347-3acsko74	119	43	,	,	,
cord-259347-3acsko74	119	44	these	these	DT
cord-259347-3acsko74	119	45	non	non	JJ
cord-259347-3acsko74	119	46	-	-	JJ
cord-259347-3acsko74	119	47	specific	specific	JJ
cord-259347-3acsko74	119	48	clinical	clinical	JJ
cord-259347-3acsko74	119	49	symptoms	symptom	NNS
cord-259347-3acsko74	119	50	and	and	CC
cord-259347-3acsko74	119	51	signs	sign	NNS
cord-259347-3acsko74	119	52	may	may	MD
cord-259347-3acsko74	119	53	be	be	VB
cord-259347-3acsko74	119	54	constitutional	constitutional	JJ
cord-259347-3acsko74	119	55	and	and	CC
cord-259347-3acsko74	119	56	represent	represent	VB
cord-259347-3acsko74	119	57	systemic	systemic	JJ
cord-259347-3acsko74	119	58	involvement	involvement	NN
cord-259347-3acsko74	119	59	rather	rather	RB
cord-259347-3acsko74	119	60	than	than	IN
cord-259347-3acsko74	119	61	direct	direct	JJ
cord-259347-3acsko74	119	62	CNS	CNS	NNP
cord-259347-3acsko74	119	63	infection	infection	NN
cord-259347-3acsko74	119	64	.	.	.
cord-259347-3acsko74	120	1	Therefore	therefore	RB
cord-259347-3acsko74	120	2	,	,	,
cord-259347-3acsko74	120	3	we	-PRON-	PRP
cord-259347-3acsko74	120	4	should	should	MD
cord-259347-3acsko74	120	5	be	be	VB
cord-259347-3acsko74	120	6	cautious	cautious	JJ
cord-259347-3acsko74	120	7	when	when	WRB
cord-259347-3acsko74	120	8	reporting	report	VBG
cord-259347-3acsko74	120	9	cases	case	NNS
cord-259347-3acsko74	120	10	with	with	IN
cord-259347-3acsko74	120	11	neurological	neurological	JJ
cord-259347-3acsko74	120	12	symptoms	symptom	NNS
cord-259347-3acsko74	120	13	and/or	and/or	CC
cord-259347-3acsko74	120	14	signs	sign	NNS
cord-259347-3acsko74	120	15	that	that	WDT
cord-259347-3acsko74	120	16	lack	lack	VBP
cord-259347-3acsko74	120	17	solid	solid	JJ
cord-259347-3acsko74	120	18	evidence	evidence	NN
cord-259347-3acsko74	120	19	for	for	IN
cord-259347-3acsko74	120	20	CNS	CNS	NNP
cord-259347-3acsko74	120	21	infection	infection	NN
cord-259347-3acsko74	121	1	(	(	-LRB-
cord-259347-3acsko74	121	2	e.g.	e.g.	IN
cord-259347-3acsko74	121	3	absence	absence	NN
cord-259347-3acsko74	121	4	of	of	IN
cord-259347-3acsko74	121	5	viral	viral	JJ
cord-259347-3acsko74	121	6	detection	detection	NN
cord-259347-3acsko74	121	7	in	in	IN
cord-259347-3acsko74	121	8	CSF	csf	NN
cord-259347-3acsko74	121	9	samples	sample	NNS
cord-259347-3acsko74	121	10	or	or	CC
cord-259347-3acsko74	121	11	abnormalities	abnormality	NNS
cord-259347-3acsko74	121	12	supportive	supportive	JJ
cord-259347-3acsko74	121	13	of	of	IN
cord-259347-3acsko74	121	14	infection	infection	NN
cord-259347-3acsko74	121	15	on	on	IN
cord-259347-3acsko74	121	16	brain	brain	NN
cord-259347-3acsko74	121	17	imaging	imaging	NN
cord-259347-3acsko74	121	18	)	)	-RRB-
cord-259347-3acsko74	121	19	.	.	.
cord-259347-3acsko74	122	1	It	-PRON-	PRP
cord-259347-3acsko74	122	2	is	be	VBZ
cord-259347-3acsko74	122	3	particularly	particularly	RB
cord-259347-3acsko74	122	4	challenging	challenging	JJ
cord-259347-3acsko74	122	5	when	when	WRB
cord-259347-3acsko74	122	6	evaluate	evaluate	VB
cord-259347-3acsko74	122	7	the	the	DT
cord-259347-3acsko74	122	8	neurological	neurological	JJ
cord-259347-3acsko74	122	9	deficits	deficit	NNS
cord-259347-3acsko74	122	10	during	during	IN
cord-259347-3acsko74	122	11	the	the	DT
cord-259347-3acsko74	122	12	advanced	advanced	JJ
cord-259347-3acsko74	122	13	stage	stage	NN
cord-259347-3acsko74	122	14	of	of	IN
cord-259347-3acsko74	122	15	COVID-19-related	covid-19-related	JJ
cord-259347-3acsko74	122	16	disease	disease	NN
cord-259347-3acsko74	122	17	.	.	.
cord-259347-3acsko74	123	1	The	the	DT
cord-259347-3acsko74	123	2	clinical	clinical	JJ
cord-259347-3acsko74	123	3	diagnosis	diagnosis	NN
cord-259347-3acsko74	123	4	and	and	CC
cord-259347-3acsko74	123	5	treatment	treatment	NN
cord-259347-3acsko74	123	6	strategy	strategy	NN
cord-259347-3acsko74	123	7	has	have	VBZ
cord-259347-3acsko74	123	8	to	to	TO
cord-259347-3acsko74	123	9	be	be	VB
cord-259347-3acsko74	123	10	made	make	VBN
cord-259347-3acsko74	123	11	on	on	IN
cord-259347-3acsko74	123	12	the	the	DT
cord-259347-3acsko74	123	13	basis	basis	NN
cord-259347-3acsko74	123	14	of	of	IN
cord-259347-3acsko74	123	15	a	a	DT
cord-259347-3acsko74	123	16	differential	differential	JJ
cord-259347-3acsko74	123	17	diagnosis	diagnosis	NN
cord-259347-3acsko74	123	18	which	which	WDT
cord-259347-3acsko74	123	19	includes	include	VBZ
cord-259347-3acsko74	123	20	hypoxia	hypoxia	NN
cord-259347-3acsko74	123	21	,	,	,
cord-259347-3acsko74	123	22	respiratory	respiratory	JJ
cord-259347-3acsko74	123	23	,	,	,
cord-259347-3acsko74	123	24	metabolic	metabolic	JJ
cord-259347-3acsko74	123	25	acidosis	acidosis	NN
cord-259347-3acsko74	123	26	,	,	,
cord-259347-3acsko74	123	27	ARDS	ARDS	NNP
cord-259347-3acsko74	123	28	-	-	HYPH
cord-259347-3acsko74	123	29	related	relate	VBN
cord-259347-3acsko74	123	30	encephalopathy	encephalopathy	NN
cord-259347-3acsko74	123	31	,	,	,
cord-259347-3acsko74	123	32	the	the	DT
cord-259347-3acsko74	123	33	effect	effect	NN
cord-259347-3acsko74	123	34	or	or	CC
cord-259347-3acsko74	123	35	withdrawal	withdrawal	NN
cord-259347-3acsko74	123	36	of	of	IN
cord-259347-3acsko74	123	37	medications	medication	NNS
cord-259347-3acsko74	123	38	,	,	,
cord-259347-3acsko74	123	39	and	and	CC
cord-259347-3acsko74	123	40	viral	viral	JJ
cord-259347-3acsko74	123	41	infection	infection	NN
cord-259347-3acsko74	123	42	of	of	IN
cord-259347-3acsko74	123	43	the	the	DT
cord-259347-3acsko74	123	44	CNS	CNS	NNP
cord-259347-3acsko74	123	45	.	.	.
cord-259347-3acsko74	124	1	PubMed	PubMed	NNP
cord-259347-3acsko74	124	2	search	search	NN
cord-259347-3acsko74	124	3	of	of	IN
cord-259347-3acsko74	124	4	articles	article	NNS
cord-259347-3acsko74	124	5	:	:	:
cord-259347-3acsko74	124	6	"	"	``
cord-259347-3acsko74	124	7	human	human	JJ
cord-259347-3acsko74	124	8	coronavirus	coronavirus	NN
cord-259347-3acsko74	124	9	"	"	''
cord-259347-3acsko74	124	10	,	,	,
cord-259347-3acsko74	124	11	"	"	``
cord-259347-3acsko74	124	12	SARS	SARS	NNP
cord-259347-3acsko74	124	13	"	"	''
cord-259347-3acsko74	124	14	,	,	,
cord-259347-3acsko74	124	15	"	"	``
cord-259347-3acsko74	124	16	MERS	MERS	NNP
cord-259347-3acsko74	124	17	"	"	''
cord-259347-3acsko74	124	18	,	,	,
cord-259347-3acsko74	124	19	"	"	``
cord-259347-3acsko74	124	20	OC43	OC43	NNP
cord-259347-3acsko74	124	21	"	"	''
cord-259347-3acsko74	124	22	,	,	,
cord-259347-3acsko74	124	23	"	"	``
cord-259347-3acsko74	124	24	229E	229E	NNP
cord-259347-3acsko74	124	25	"	"	''
cord-259347-3acsko74	124	26	,	,	,
cord-259347-3acsko74	124	27	"	"	``
cord-259347-3acsko74	124	28	neurological	neurological	JJ
cord-259347-3acsko74	124	29	symptom	symptom	NN
cord-259347-3acsko74	124	30	"	"	''
cord-259347-3acsko74	124	31	,	,	,
cord-259347-3acsko74	124	32	"	"	''
cord-259347-3acsko74	124	33	neurological	neurological	JJ
cord-259347-3acsko74	124	34	sign	sign	NN
cord-259347-3acsko74	124	35	"	"	''
cord-259347-3acsko74	124	36	,	,	,
cord-259347-3acsko74	124	37	"	"	``
cord-259347-3acsko74	124	38	neurological	neurological	JJ
cord-259347-3acsko74	124	39	manifestation	manifestation	NN
cord-259347-3acsko74	124	40	"	"	''
cord-259347-3acsko74	124	41	,	,	,
cord-259347-3acsko74	124	42	"	"	``
cord-259347-3acsko74	124	43	neuroinvasion	neuroinvasion	NN
cord-259347-3acsko74	124	44	"	"	''
cord-259347-3acsko74	124	45	,	,	,
cord-259347-3acsko74	124	46	and	and	CC
cord-259347-3acsko74	124	47	"	"	``
cord-259347-3acsko74	124	48	neurovirulence	neurovirulence	NNP
cord-259347-3acsko74	124	49	"	"	''
cord-259347-3acsko74	124	50	.	.	.
cord-259347-3acsko74	125	1	Additional	additional	JJ
cord-259347-3acsko74	125	2	articles	article	NNS
cord-259347-3acsko74	125	3	were	be	VBD
cord-259347-3acsko74	125	4	selected	select	VBN
cord-259347-3acsko74	125	5	based	base	VBN
cord-259347-3acsko74	125	6	on	on	IN
cord-259347-3acsko74	125	7	articles	article	NNS
cord-259347-3acsko74	125	8	in	in	IN
cord-259347-3acsko74	125	9	these	these	DT
cord-259347-3acsko74	125	10	searches	search	NNS
cord-259347-3acsko74	125	11	and	and	CC
cord-259347-3acsko74	125	12	as	as	IN
cord-259347-3acsko74	125	13	suggested	suggest	VBN
cord-259347-3acsko74	125	14	by	by	IN
cord-259347-3acsko74	125	15	reviewers	reviewer	NNS
cord-259347-3acsko74	125	16	.	.	.
cord-259347-3acsko74	126	1	We	-PRON-	PRP
cord-259347-3acsko74	126	2	declare	declare	VBP
cord-259347-3acsko74	126	3	no	no	DT
cord-259347-3acsko74	126	4	conflicts	conflict	NNS
cord-259347-3acsko74	126	5	of	of	IN
cord-259347-3acsko74	126	6	interest	interest	NN
cord-259347-3acsko74	126	7	.	.	.
cord-259347-3acsko74	127	1	Identification	identification	NN
cord-259347-3acsko74	127	2	of	of	IN
cord-259347-3acsko74	127	3	an	an	DT
cord-259347-3acsko74	127	4	epitope	epitope	NN
cord-259347-3acsko74	127	5	of	of	IN
cord-259347-3acsko74	127	6	SARS	SARS	NNP
cord-259347-3acsko74	127	7	-	-	HYPH
cord-259347-3acsko74	127	8	coronavirus	coronavirus	NN
cord-259347-3acsko74	127	9	nucleocapsid	nucleocapsid	NN
cord-259347-3acsko74	127	10	protein	protein	NN
cord-259347-3acsko74	127	11	Engineering	Engineering	NNP
cord-259347-3acsko74	127	12	the	the	DT
cord-259347-3acsko74	127	13	largest	large	JJS
cord-259347-3acsko74	127	14	RNA	RNA	NNP
cord-259347-3acsko74	127	15	virus	virus	NN
cord-259347-3acsko74	127	16	genome	genome	NN
cord-259347-3acsko74	127	17	as	as	IN
cord-259347-3acsko74	127	18	an	an	DT
cord-259347-3acsko74	127	19	infectious	infectious	JJ
cord-259347-3acsko74	127	20	bacterial	bacterial	JJ
cord-259347-3acsko74	127	21	artificial	artificial	JJ
cord-259347-3acsko74	127	22	chromosome	chromosome	NN
cord-259347-3acsko74	127	23	Neuroinvasion	neuroinvasion	NN
cord-259347-3acsko74	127	24	by	by	IN
cord-259347-3acsko74	127	25	human	human	JJ
cord-259347-3acsko74	127	26	respiratory	respiratory	JJ
cord-259347-3acsko74	127	27	coronaviruses	coronaviruse	NNS
cord-259347-3acsko74	128	1	Vacuolating	vacuolate	VBG
cord-259347-3acsko74	128	2	encephalitis	encephalitis	RB
cord-259347-3acsko74	128	3	in	in	IN
cord-259347-3acsko74	128	4	mice	mouse	NNS
cord-259347-3acsko74	128	5	infected	infect	VBN
cord-259347-3acsko74	128	6	by	by	IN
cord-259347-3acsko74	128	7	human	human	JJ
cord-259347-3acsko74	128	8	coronavirus	coronavirus	NN
cord-259347-3acsko74	128	9	OC43	OC43	NNP
cord-259347-3acsko74	128	10	Human	Human	NNP
cord-259347-3acsko74	128	11	respiratory	respiratory	JJ
cord-259347-3acsko74	128	12	coronavirus	coronavirus	NN
cord-259347-3acsko74	128	13	OC43	OC43	NNP
cord-259347-3acsko74	128	14	:	:	:
cord-259347-3acsko74	129	1	genetic	genetic	JJ
cord-259347-3acsko74	129	2	stability	stability	NN
cord-259347-3acsko74	129	3	and	and	CC
cord-259347-3acsko74	129	4	neuroinvasion	neuroinvasion	NN
cord-259347-3acsko74	129	5	Genomic	genomic	JJ
cord-259347-3acsko74	129	6	characterisation	characterisation	NN
cord-259347-3acsko74	129	7	and	and	CC
cord-259347-3acsko74	129	8	epidemiology	epidemiology	NN
cord-259347-3acsko74	129	9	of	of	IN
cord-259347-3acsko74	129	10	2019	2019	CD
cord-259347-3acsko74	129	11	novel	novel	JJ
cord-259347-3acsko74	129	12	coronavirus	coronavirus	NN
cord-259347-3acsko74	129	13	:	:	:
cord-259347-3acsko74	129	14	implications	implication	NNS
cord-259347-3acsko74	129	15	for	for	IN
cord-259347-3acsko74	129	16	virus	virus	NN
cord-259347-3acsko74	129	17	origins	origin	NNS
cord-259347-3acsko74	129	18	and	and	CC
cord-259347-3acsko74	129	19	receptor	receptor	NN
cord-259347-3acsko74	129	20	binding	bind	VBG
cord-259347-3acsko74	129	21	Neurological	neurological	JJ
cord-259347-3acsko74	129	22	manifestations	manifestation	NNS
cord-259347-3acsko74	129	23	in	in	IN
cord-259347-3acsko74	129	24	COVID-19	covid-19	NN
cord-259347-3acsko74	129	25	caused	cause	VBN
cord-259347-3acsko74	129	26	by	by	IN
cord-259347-3acsko74	129	27	SARS	SARS	NNP
cord-259347-3acsko74	129	28	-	-	HYPH
cord-259347-3acsko74	129	29	CoV-2	CoV-2	NNP
cord-259347-3acsko74	129	30	Persistent	persistent	JJ
cord-259347-3acsko74	129	31	infection	infection	NN
cord-259347-3acsko74	129	32	of	of	IN
cord-259347-3acsko74	129	33	human	human	JJ
cord-259347-3acsko74	129	34	oligodendrocytic	oligodendrocytic	JJ
cord-259347-3acsko74	129	35	and	and	CC
cord-259347-3acsko74	129	36	neuroglial	neuroglial	JJ
cord-259347-3acsko74	129	37	cell	cell	NN
cord-259347-3acsko74	129	38	lines	line	NNS
cord-259347-3acsko74	129	39	by	by	IN
cord-259347-3acsko74	129	40	human	human	JJ
cord-259347-3acsko74	129	41	coronavirus	coronavirus	NN
cord-259347-3acsko74	129	42	229E	229e	CD
cord-259347-3acsko74	129	43	Acute	acute	JJ
cord-259347-3acsko74	129	44	and	and	CC
cord-259347-3acsko74	129	45	persistent	persistent	JJ
cord-259347-3acsko74	129	46	infection	infection	NN
cord-259347-3acsko74	129	47	of	of	IN
cord-259347-3acsko74	129	48	human	human	JJ
cord-259347-3acsko74	129	49	neural	neural	JJ
cord-259347-3acsko74	129	50	cell	cell	NN
cord-259347-3acsko74	129	51	lines	line	NNS
cord-259347-3acsko74	129	52	by	by	IN
cord-259347-3acsko74	129	53	human	human	JJ
cord-259347-3acsko74	129	54	coronavirus	coronavirus	NN
cord-259347-3acsko74	129	55	OC43	OC43	NNP
cord-259347-3acsko74	129	56	Infection	Infection	NNP
cord-259347-3acsko74	129	57	of	of	IN
cord-259347-3acsko74	129	58	primary	primary	JJ
cord-259347-3acsko74	129	59	cultures	culture	NNS
cord-259347-3acsko74	129	60	of	of	IN
cord-259347-3acsko74	129	61	human	human	JJ
cord-259347-3acsko74	129	62	neural	neural	JJ
cord-259347-3acsko74	129	63	cells	cell	NNS
cord-259347-3acsko74	129	64	by	by	IN
cord-259347-3acsko74	129	65	human	human	JJ
cord-259347-3acsko74	129	66	coronaviruses	coronaviruse	NNS
cord-259347-3acsko74	129	67	229E	229e	CD
cord-259347-3acsko74	129	68	and	and	CC
cord-259347-3acsko74	129	69	OC43	OC43	NNP
cord-259347-3acsko74	129	70	Murine	Murine	NNP
cord-259347-3acsko74	129	71	encephalitis	encephalitis	RB
cord-259347-3acsko74	129	72	caused	cause	VBN
cord-259347-3acsko74	129	73	by	by	IN
cord-259347-3acsko74	129	74	HCoV	HCoV	NNP
cord-259347-3acsko74	129	75	-	-	HYPH
cord-259347-3acsko74	129	76	OC43	OC43	NNP
cord-259347-3acsko74	129	77	,	,	,
cord-259347-3acsko74	129	78	a	a	DT
cord-259347-3acsko74	129	79	human	human	JJ
cord-259347-3acsko74	129	80	coronavirus	coronavirus	NN
cord-259347-3acsko74	129	81	with	with	IN
cord-259347-3acsko74	129	82	broad	broad	JJ
cord-259347-3acsko74	129	83	species	specie	NNS
cord-259347-3acsko74	129	84	specificity	specificity	NN
cord-259347-3acsko74	129	85	,	,	,
cord-259347-3acsko74	129	86	is	be	VBZ
cord-259347-3acsko74	129	87	partly	partly	RB
cord-259347-3acsko74	129	88	immunemediated	immunemediate	VBN
cord-259347-3acsko74	129	89	Susceptibility	Susceptibility	NNP
cord-259347-3acsko74	129	90	of	of	IN
cord-259347-3acsko74	129	91	murine	murine	JJ
cord-259347-3acsko74	129	92	CNS	CNS	NNP
cord-259347-3acsko74	129	93	to	to	IN
cord-259347-3acsko74	129	94	OC43	OC43	NNP
cord-259347-3acsko74	129	95	infection	infection	NN
cord-259347-3acsko74	130	1	Axonal	Axonal	NNP
cord-259347-3acsko74	130	2	Transport	Transport	NNP
cord-259347-3acsko74	130	3	Enables	enable	VBZ
cord-259347-3acsko74	130	4	Neuron	Neuron	NNP
cord-259347-3acsko74	130	5	-	-	HYPH
cord-259347-3acsko74	130	6	to	to	IN
cord-259347-3acsko74	130	7	-	-	HYPH
cord-259347-3acsko74	130	8	Neuron	Neuron	NNP
cord-259347-3acsko74	130	9	Propagation	Propagation	NNP
cord-259347-3acsko74	130	10	of	of	IN
cord-259347-3acsko74	130	11	Human	Human	NNP
cord-259347-3acsko74	130	12	Coronavirus	Coronavirus	NNP
cord-259347-3acsko74	130	13	OC43	OC43	NNP
cord-259347-3acsko74	130	14	Detection	Detection	NNP
cord-259347-3acsko74	130	15	of	of	IN
cord-259347-3acsko74	130	16	coronavirus	coronavirus	NN
cord-259347-3acsko74	130	17	in	in	IN
cord-259347-3acsko74	130	18	the	the	DT
cord-259347-3acsko74	130	19	central	central	JJ
cord-259347-3acsko74	130	20	nervous	nervous	JJ
cord-259347-3acsko74	130	21	system	system	NN
cord-259347-3acsko74	130	22	of	of	IN
cord-259347-3acsko74	130	23	a	a	DT
cord-259347-3acsko74	130	24	child	child	NN
cord-259347-3acsko74	130	25	with	with	IN
cord-259347-3acsko74	130	26	acute	acute	JJ
cord-259347-3acsko74	130	27	disseminated	disseminate	VBN
cord-259347-3acsko74	130	28	encephalomyelitis	encephalomyelitis	NN
cord-259347-3acsko74	130	29	Human	Human	NNP
cord-259347-3acsko74	130	30	Coronavirus	Coronavirus	NNP
cord-259347-3acsko74	130	31	OC43	OC43	NNP
cord-259347-3acsko74	130	32	Associated	Associated	NNP
cord-259347-3acsko74	130	33	with	with	IN
cord-259347-3acsko74	130	34	Fatal	fatal	JJ
cord-259347-3acsko74	130	35	Encephalitis	Encephalitis	NNP
cord-259347-3acsko74	130	36	A	a	DT
cord-259347-3acsko74	130	37	rare	rare	JJ
cord-259347-3acsko74	130	38	cause	cause	NN
cord-259347-3acsko74	130	39	of	of	IN
cord-259347-3acsko74	130	40	acute	acute	JJ
cord-259347-3acsko74	130	41	flaccid	flaccid	JJ
cord-259347-3acsko74	130	42	paralysis	paralysis	NN
cord-259347-3acsko74	130	43	:	:	:
cord-259347-3acsko74	130	44	human	human	JJ
cord-259347-3acsko74	130	45	coronaviruses	coronaviruse	NNS
cord-259347-3acsko74	130	46	Susceptibility	Susceptibility	NNP
cord-259347-3acsko74	130	47	of	of	IN
cord-259347-3acsko74	130	48	human	human	NN
cord-259347-3acsko74	130	49	and	and	CC
cord-259347-3acsko74	130	50	rat	rat	NN
cord-259347-3acsko74	130	51	neural	neural	JJ
cord-259347-3acsko74	130	52	cell	cell	NN
cord-259347-3acsko74	130	53	lines	line	NNS
cord-259347-3acsko74	130	54	to	to	IN
cord-259347-3acsko74	130	55	infection	infection	NN
cord-259347-3acsko74	130	56	by	by	IN
cord-259347-3acsko74	130	57	SARS	SARS	NNP
cord-259347-3acsko74	130	58	-	-	HYPH
cord-259347-3acsko74	130	59	coronavirus	coronavirus	NN
cord-259347-3acsko74	130	60	Severe	severe	JJ
cord-259347-3acsko74	130	61	acute	acute	JJ
cord-259347-3acsko74	130	62	respiratory	respiratory	JJ
cord-259347-3acsko74	130	63	syndrome	syndrome	NN
cord-259347-3acsko74	130	64	coronavirus	coronavirus	NN
cord-259347-3acsko74	130	65	infection	infection	NN
cord-259347-3acsko74	130	66	causes	cause	VBZ
cord-259347-3acsko74	130	67	neuronal	neuronal	JJ
cord-259347-3acsko74	130	68	death	death	NN
cord-259347-3acsko74	130	69	in	in	IN
cord-259347-3acsko74	130	70	the	the	DT
cord-259347-3acsko74	130	71	absence	absence	NN
cord-259347-3acsko74	130	72	of	of	IN
cord-259347-3acsko74	130	73	encephalitis	encephalitis	NN
cord-259347-3acsko74	130	74	in	in	IN
cord-259347-3acsko74	130	75	mice	mouse	NNS
cord-259347-3acsko74	130	76	transgenic	transgenic	JJ
cord-259347-3acsko74	130	77	for	for	IN
cord-259347-3acsko74	130	78	human	human	JJ
cord-259347-3acsko74	130	79	ACE2	ACE2	NNP
cord-259347-3acsko74	130	80	Mechanisms	Mechanisms	NNPS
cord-259347-3acsko74	130	81	of	of	IN
cord-259347-3acsko74	130	82	host	host	NN
cord-259347-3acsko74	130	83	defense	defense	NN
cord-259347-3acsko74	130	84	following	follow	VBG
cord-259347-3acsko74	130	85	severe	severe	JJ
cord-259347-3acsko74	130	86	acute	acute	JJ
cord-259347-3acsko74	130	87	respiratory	respiratory	JJ
cord-259347-3acsko74	130	88	syndrome	syndrome	NN
cord-259347-3acsko74	130	89	-	-	HYPH
cord-259347-3acsko74	130	90	coronavirus	coronavirus	NN
cord-259347-3acsko74	130	91	(	(	-LRB-
cord-259347-3acsko74	130	92	SARS	SARS	NNP
cord-259347-3acsko74	130	93	-	-	HYPH
cord-259347-3acsko74	130	94	CoV	CoV	NNP
cord-259347-3acsko74	130	95	)	)	-RRB-
cord-259347-3acsko74	130	96	pulmonary	pulmonary	JJ
cord-259347-3acsko74	130	97	infection	infection	NN
cord-259347-3acsko74	130	98	of	of	IN
cord-259347-3acsko74	130	99	mice	mouse	NNS
cord-259347-3acsko74	131	1	A	a	DT
cord-259347-3acsko74	131	2	mouse	mouse	NN
cord-259347-3acsko74	131	3	-	-	HYPH
cord-259347-3acsko74	131	4	adapted	adapt	VBN
cord-259347-3acsko74	131	5	SARS	SARS	NNP
cord-259347-3acsko74	131	6	-	-	HYPH
cord-259347-3acsko74	131	7	coronavirus	coronavirus	NN
cord-259347-3acsko74	131	8	causes	cause	VBZ
cord-259347-3acsko74	131	9	disease	disease	NN
cord-259347-3acsko74	131	10	and	and	CC
cord-259347-3acsko74	131	11	mortality	mortality	NN
cord-259347-3acsko74	131	12	in	in	IN
cord-259347-3acsko74	131	13	BALB	BALB	NNP
cord-259347-3acsko74	131	14	/	/	SYM
cord-259347-3acsko74	131	15	c	c	NN
cord-259347-3acsko74	131	16	mice	mouse	NNS
cord-259347-3acsko74	132	1	Severe	severe	JJ
cord-259347-3acsko74	132	2	acute	acute	JJ
cord-259347-3acsko74	132	3	respiratory	respiratory	JJ
cord-259347-3acsko74	132	4	syndrome	syndrome	NN
cord-259347-3acsko74	132	5	coronavirus	coronavirus	NN
cord-259347-3acsko74	132	6	infection	infection	NN
cord-259347-3acsko74	132	7	of	of	IN
cord-259347-3acsko74	132	8	mice	mouse	NNS
cord-259347-3acsko74	132	9	transgenic	transgenic	JJ
cord-259347-3acsko74	132	10	for	for	IN
cord-259347-3acsko74	132	11	the	the	DT
cord-259347-3acsko74	132	12	human	human	JJ
cord-259347-3acsko74	132	13	Angiotensin	Angiotensin	NNP
cord-259347-3acsko74	132	14	-	-	HYPH
cord-259347-3acsko74	132	15	converting	convert	VBG
cord-259347-3acsko74	132	16	enzyme	enzyme	NN
cord-259347-3acsko74	132	17	2	2	CD
cord-259347-3acsko74	132	18	virus	virus	NN
cord-259347-3acsko74	132	19	receptor	receptor	NN
cord-259347-3acsko74	132	20	Lethal	lethal	JJ
cord-259347-3acsko74	132	21	infection	infection	NN
cord-259347-3acsko74	132	22	of	of	IN
cord-259347-3acsko74	132	23	K18-hACE2	k18-hace2	JJ
cord-259347-3acsko74	132	24	mice	mouse	NNS
cord-259347-3acsko74	132	25	infected	infect	VBN
cord-259347-3acsko74	132	26	with	with	IN
cord-259347-3acsko74	132	27	severe	severe	JJ
cord-259347-3acsko74	132	28	acute	acute	JJ
cord-259347-3acsko74	132	29	respiratory	respiratory	JJ
cord-259347-3acsko74	132	30	syndrome	syndrome	NN
cord-259347-3acsko74	132	31	coronavirus	coronavirus	NN
cord-259347-3acsko74	132	32	Differential	differential	NN
cord-259347-3acsko74	132	33	virological	virological	JJ
cord-259347-3acsko74	132	34	and	and	CC
cord-259347-3acsko74	132	35	immunological	immunological	JJ
cord-259347-3acsko74	132	36	outcome	outcome	NN
cord-259347-3acsko74	132	37	of	of	IN
cord-259347-3acsko74	132	38	severe	severe	JJ
cord-259347-3acsko74	132	39	acute	acute	JJ
cord-259347-3acsko74	132	40	respiratory	respiratory	JJ
cord-259347-3acsko74	132	41	syndrome	syndrome	NN
cord-259347-3acsko74	132	42	coronavirus	coronavirus	NN
cord-259347-3acsko74	132	43	infection	infection	NN
cord-259347-3acsko74	132	44	in	in	IN
cord-259347-3acsko74	132	45	susceptible	susceptible	JJ
cord-259347-3acsko74	132	46	and	and	CC
cord-259347-3acsko74	132	47	resistant	resistant	JJ
cord-259347-3acsko74	132	48	transgenic	transgenic	JJ
cord-259347-3acsko74	132	49	mice	mouse	NNS
cord-259347-3acsko74	132	50	expressing	express	VBG
cord-259347-3acsko74	132	51	human	human	JJ
cord-259347-3acsko74	132	52	angiotensin	angiotensin	NN
cord-259347-3acsko74	132	53	-	-	HYPH
cord-259347-3acsko74	132	54	converting	convert	VBG
cord-259347-3acsko74	132	55	enzyme	enzyme	NN
cord-259347-3acsko74	132	56	2	2	CD
cord-259347-3acsko74	132	57	Generation	generation	NN
cord-259347-3acsko74	132	58	of	of	IN
cord-259347-3acsko74	132	59	a	a	DT
cord-259347-3acsko74	132	60	transgenic	transgenic	JJ
cord-259347-3acsko74	132	61	mouse	mouse	NN
cord-259347-3acsko74	132	62	model	model	NN
cord-259347-3acsko74	132	63	of	of	IN
cord-259347-3acsko74	132	64	Middle	Middle	NNP
cord-259347-3acsko74	132	65	East	East	NNP
cord-259347-3acsko74	132	66	respiratory	respiratory	JJ
cord-259347-3acsko74	132	67	syndrome	syndrome	NN
cord-259347-3acsko74	132	68	coronavirus	coronavirus	NN
cord-259347-3acsko74	132	69	infection	infection	NN
cord-259347-3acsko74	132	70	and	and	CC
cord-259347-3acsko74	132	71	disease	disease	NN
cord-259347-3acsko74	132	72	middle	middle	NNP
cord-259347-3acsko74	132	73	east	east	NNP
cord-259347-3acsko74	132	74	respiratory	respiratory	JJ
cord-259347-3acsko74	132	75	syndrome	syndrome	NN
cord-259347-3acsko74	132	76	coronavirus	coronavirus	NN
cord-259347-3acsko74	132	77	causes	cause	VBZ
cord-259347-3acsko74	132	78	multiple	multiple	JJ
cord-259347-3acsko74	132	79	organ	organ	NN
cord-259347-3acsko74	132	80	damage	damage	NN
cord-259347-3acsko74	132	81	and	and	CC
cord-259347-3acsko74	132	82	lethal	lethal	JJ
cord-259347-3acsko74	132	83	disease	disease	NN
cord-259347-3acsko74	132	84	in	in	IN
cord-259347-3acsko74	132	85	mice	mouse	NNS
cord-259347-3acsko74	132	86	transgenic	transgenic	JJ
cord-259347-3acsko74	132	87	for	for	IN
cord-259347-3acsko74	132	88	human	human	JJ
cord-259347-3acsko74	132	89	Dipeptidyl	Dipeptidyl	NNP
cord-259347-3acsko74	132	90	peptidase	peptidase	NN
cord-259347-3acsko74	132	91	4	4	CD
cord-259347-3acsko74	132	92	Detection	detection	NN
cord-259347-3acsko74	132	93	of	of	IN
cord-259347-3acsko74	132	94	severe	severe	JJ
cord-259347-3acsko74	132	95	acute	acute	JJ
cord-259347-3acsko74	132	96	respiratory	respiratory	JJ
cord-259347-3acsko74	132	97	syndrome	syndrome	NN
cord-259347-3acsko74	132	98	coronavirus	coronavirus	NN
cord-259347-3acsko74	132	99	in	in	IN
cord-259347-3acsko74	132	100	the	the	DT
cord-259347-3acsko74	132	101	brain	brain	NN
cord-259347-3acsko74	132	102	:	:	:
cord-259347-3acsko74	132	103	potential	potential	JJ
cord-259347-3acsko74	132	104	role	role	NN
cord-259347-3acsko74	132	105	of	of	IN
cord-259347-3acsko74	132	106	the	the	DT
cord-259347-3acsko74	132	107	chemokine	chemokine	NN
cord-259347-3acsko74	132	108	mig	mig	NNP
cord-259347-3acsko74	132	109	in	in	IN
cord-259347-3acsko74	132	110	pathogenesis	pathogenesis	NN
cord-259347-3acsko74	132	111	Multiple	multiple	JJ
cord-259347-3acsko74	132	112	organ	organ	NN
cord-259347-3acsko74	132	113	infection	infection	NN
cord-259347-3acsko74	132	114	and	and	CC
cord-259347-3acsko74	132	115	the	the	DT
cord-259347-3acsko74	132	116	pathogenesis	pathogenesis	NN
cord-259347-3acsko74	132	117	of	of	IN
cord-259347-3acsko74	132	118	SARS	SARS	NNP
cord-259347-3acsko74	132	119	Organ	Organ	NNP
cord-259347-3acsko74	132	120	distribution	distribution	NN
cord-259347-3acsko74	132	121	of	of	IN
cord-259347-3acsko74	132	122	severe	severe	JJ
cord-259347-3acsko74	132	123	acute	acute	JJ
cord-259347-3acsko74	132	124	respiratory	respiratory	JJ
cord-259347-3acsko74	132	125	syndrome	syndrome	NN
cord-259347-3acsko74	132	126	(	(	-LRB-
cord-259347-3acsko74	132	127	SARS	SARS	NNP
cord-259347-3acsko74	132	128	)	)	-RRB-
cord-259347-3acsko74	132	129	associated	associate	VBD
cord-259347-3acsko74	132	130	coronavirus	coronavirus	NN
cord-259347-3acsko74	132	131	(	(	-LRB-
cord-259347-3acsko74	132	132	SARS	SARS	NNP
cord-259347-3acsko74	132	133	-	-	HYPH
cord-259347-3acsko74	132	134	CoV	CoV	NNP
cord-259347-3acsko74	132	135	)	)	-RRB-
cord-259347-3acsko74	132	136	in	in	IN
cord-259347-3acsko74	132	137	SARS	SARS	NNP
cord-259347-3acsko74	132	138	patients	patient	NNS
cord-259347-3acsko74	132	139	:	:	:
cord-259347-3acsko74	132	140	implications	implication	NNS
cord-259347-3acsko74	132	141	for	for	IN
cord-259347-3acsko74	132	142	pathogenesis	pathogenesis	NN
cord-259347-3acsko74	132	143	and	and	CC
cord-259347-3acsko74	132	144	virus	virus	NN
cord-259347-3acsko74	132	145	transmission	transmission	NN
cord-259347-3acsko74	132	146	pathways	pathway	NNS
cord-259347-3acsko74	133	1	Possible	possible	JJ
cord-259347-3acsko74	133	2	central	central	JJ
cord-259347-3acsko74	133	3	nervous	nervous	JJ
cord-259347-3acsko74	133	4	system	system	NN
cord-259347-3acsko74	133	5	infection	infection	NN
cord-259347-3acsko74	133	6	by	by	IN
cord-259347-3acsko74	133	7	SARS	SARS	NNP
cord-259347-3acsko74	133	8	coronavirus	coronavirus	NN
cord-259347-3acsko74	133	9	Detection	Detection	NNP
cord-259347-3acsko74	133	10	of	of	IN
cord-259347-3acsko74	133	11	SARS	SARS	NNP
cord-259347-3acsko74	133	12	coronavirus	coronavirus	NN
cord-259347-3acsko74	133	13	RNA	RNA	NNP
cord-259347-3acsko74	133	14	in	in	IN
cord-259347-3acsko74	133	15	the	the	DT
cord-259347-3acsko74	133	16	cerebrospinal	cerebrospinal	JJ
cord-259347-3acsko74	133	17	fluid	fluid	NN
cord-259347-3acsko74	133	18	of	of	IN
cord-259347-3acsko74	133	19	a	a	DT
cord-259347-3acsko74	133	20	patient	patient	NN
cord-259347-3acsko74	133	21	with	with	IN
cord-259347-3acsko74	133	22	severe	severe	JJ
cord-259347-3acsko74	133	23	acute	acute	JJ
cord-259347-3acsko74	133	24	respiratory	respiratory	JJ
cord-259347-3acsko74	133	25	syndrome	syndrome	NN
cord-259347-3acsko74	133	26	Severe	severe	JJ
cord-259347-3acsko74	133	27	neurologic	neurologic	JJ
cord-259347-3acsko74	133	28	syndrome	syndrome	NN
cord-259347-3acsko74	133	29	associated	associate	VBN
cord-259347-3acsko74	133	30	with	with	IN
cord-259347-3acsko74	133	31	Middle	Middle	NNP
cord-259347-3acsko74	133	32	East	East	NNP
cord-259347-3acsko74	133	33	respiratory	respiratory	JJ
cord-259347-3acsko74	133	34	syndrome	syndrome	NN
cord-259347-3acsko74	133	35	corona	corona	NN
cord-259347-3acsko74	133	36	virus	virus	NN
cord-259347-3acsko74	133	37	(	(	-LRB-
cord-259347-3acsko74	133	38	MERS	MERS	NNP
cord-259347-3acsko74	133	39	-	-	HYPH
cord-259347-3acsko74	133	40	CoV	CoV	NNP
cord-259347-3acsko74	133	41	)	)	-RRB-
cord-259347-3acsko74	134	1	Neurological	Neurological	NNP
cord-259347-3acsko74	134	2	Complications	Complications	NNPS
cord-259347-3acsko74	134	3	of	of	IN
cord-259347-3acsko74	134	4	Middle	Middle	NNP
cord-259347-3acsko74	134	5	East	East	NNP
cord-259347-3acsko74	134	6	Respiratory	Respiratory	NNP
cord-259347-3acsko74	134	7	Syndrome	Syndrome	NNP
cord-259347-3acsko74	134	8	Coronavirus	Coronavirus	NNP
cord-259347-3acsko74	134	9	:	:	:
cord-259347-3acsko74	134	10	a	a	DT
cord-259347-3acsko74	134	11	Report	Report	NNP
cord-259347-3acsko74	134	12	of	of	IN
cord-259347-3acsko74	134	13	Two	two	CD
cord-259347-3acsko74	134	14	Cases	Cases	NNPS
cord-259347-3acsko74	134	15	and	and	CC
cord-259347-3acsko74	134	16	Review	Review	NNP
cord-259347-3acsko74	134	17	of	of	IN
cord-259347-3acsko74	134	18	the	the	DT
cord-259347-3acsko74	134	19	Literature	Literature	NNP
cord-259347-3acsko74	134	20	Effect	Effect	NNP
cord-259347-3acsko74	134	21	of	of	IN
cord-259347-3acsko74	134	22	olfactory	olfactory	JJ
cord-259347-3acsko74	134	23	bulb	bulb	NN
cord-259347-3acsko74	134	24	ablation	ablation	NN
cord-259347-3acsko74	134	25	on	on	IN
cord-259347-3acsko74	134	26	spread	spread	NN
cord-259347-3acsko74	134	27	of	of	IN
cord-259347-3acsko74	134	28	a	a	DT
cord-259347-3acsko74	134	29	neurotropic	neurotropic	JJ
cord-259347-3acsko74	134	30	coronavirus	coronavirus	NN
cord-259347-3acsko74	134	31	into	into	IN
cord-259347-3acsko74	134	32	the	the	DT
cord-259347-3acsko74	134	33	mouse	mouse	NN
cord-259347-3acsko74	134	34	brain	brain	NN
cord-259347-3acsko74	135	1	Viremic	viremic	JJ
cord-259347-3acsko74	135	2	dissemination	dissemination	NN
cord-259347-3acsko74	135	3	of	of	IN
cord-259347-3acsko74	135	4	mouse	mouse	NN
cord-259347-3acsko74	135	5	hepatitis	hepatitis	NNP
cord-259347-3acsko74	135	6	virus	virus	NN
cord-259347-3acsko74	135	7	-	-	:
cord-259347-3acsko74	135	8	JHM	JHM	NNP
cord-259347-3acsko74	135	9	following	follow	VBG
cord-259347-3acsko74	135	10	intranasal	intranasal	NN
cord-259347-3acsko74	135	11	inoculation	inoculation	NN
cord-259347-3acsko74	135	12	of	of	IN
cord-259347-3acsko74	135	13	mice	mouse	NNS
cord-259347-3acsko74	135	14	Middle	Middle	NNP
cord-259347-3acsko74	135	15	East	East	NNP
cord-259347-3acsko74	135	16	respiratory	respiratory	JJ
cord-259347-3acsko74	135	17	syndrome	syndrome	NN
cord-259347-3acsko74	135	18	coronavirus	coronavirus	NN
cord-259347-3acsko74	135	19	:	:	:
cord-259347-3acsko74	135	20	another	another	DT
cord-259347-3acsko74	135	21	zoonotic	zoonotic	JJ
cord-259347-3acsko74	135	22	betacoronavirus	betacoronavirus	NN
cord-259347-3acsko74	135	23	causing	cause	VBG
cord-259347-3acsko74	135	24	SARS	SARS	NNP
cord-259347-3acsko74	135	25	-	-	HYPH
cord-259347-3acsko74	135	26	like	like	JJ
cord-259347-3acsko74	135	27	disease	disease	NN
cord-259347-3acsko74	135	28	Immunological	immunological	JJ
cord-259347-3acsko74	135	29	and	and	CC
cord-259347-3acsko74	135	30	neuropathological	neuropathological	JJ
cord-259347-3acsko74	135	31	significance	significance	NN
cord-259347-3acsko74	135	32	of	of	IN
cord-259347-3acsko74	135	33	the	the	DT
cord-259347-3acsko74	135	34	Virchow	Virchow	NNP
cord-259347-3acsko74	135	35	-	-	HYPH
cord-259347-3acsko74	135	36	Robin	Robin	NNP
cord-259347-3acsko74	135	37	space	space	NN
cord-259347-3acsko74	135	38	Dilated	dilate	VBD
cord-259347-3acsko74	135	39	Virchow	Virchow	NNP
cord-259347-3acsko74	135	40	-	-	HYPH
cord-259347-3acsko74	135	41	Robin	Robin	NNP
cord-259347-3acsko74	135	42	spaces	space	NNS
cord-259347-3acsko74	135	43	in	in	IN
cord-259347-3acsko74	135	44	cryptococcal	cryptococcal	JJ
cord-259347-3acsko74	135	45	meningitis	meningitis	NN
cord-259347-3acsko74	135	46	associated	associate	VBN
cord-259347-3acsko74	135	47	with	with	IN
cord-259347-3acsko74	135	48	AIDS	AIDS	NNP
cord-259347-3acsko74	135	49	:	:	:
cord-259347-3acsko74	136	1	CT	CT	NNP
cord-259347-3acsko74	136	2	and	and	CC
cord-259347-3acsko74	136	3	MR	MR	NNP
cord-259347-3acsko74	136	4	findings	finding	NNS
cord-259347-3acsko74	137	1	The	the	DT
cord-259347-3acsko74	137	2	clinical	clinical	JJ
cord-259347-3acsko74	137	3	pathology	pathology	NN
cord-259347-3acsko74	137	4	of	of	IN
cord-259347-3acsko74	137	5	severe	severe	JJ
cord-259347-3acsko74	137	6	acute	acute	JJ
cord-259347-3acsko74	137	7	respiratory	respiratory	JJ
cord-259347-3acsko74	137	8	syndrome	syndrome	NN
cord-259347-3acsko74	137	9	(	(	-LRB-
cord-259347-3acsko74	137	10	SARS	SARS	NNP
cord-259347-3acsko74	137	11	)	)	-RRB-
cord-259347-3acsko74	137	12	:	:	:
cord-259347-3acsko74	138	1	a	a	DT
cord-259347-3acsko74	138	2	report	report	NN
cord-259347-3acsko74	138	3	from	from	IN
cord-259347-3acsko74	138	4	China	China	NNP
cord-259347-3acsko74	138	5	Persistence	Persistence	NNP
cord-259347-3acsko74	138	6	of	of	IN
cord-259347-3acsko74	138	7	physical	physical	JJ
cord-259347-3acsko74	138	8	symptoms	symptom	NNS
cord-259347-3acsko74	138	9	in	in	IN
cord-259347-3acsko74	138	10	and	and	CC
cord-259347-3acsko74	138	11	abnormal	abnormal	JJ
cord-259347-3acsko74	138	12	laboratory	laboratory	NN
cord-259347-3acsko74	138	13	findings	finding	NNS
cord-259347-3acsko74	138	14	for	for	IN
cord-259347-3acsko74	138	15	survivors	survivor	NNS
cord-259347-3acsko74	138	16	of	of	IN
cord-259347-3acsko74	138	17	severe	severe	JJ
cord-259347-3acsko74	138	18	acute	acute	JJ
cord-259347-3acsko74	138	19	respiratory	respiratory	JJ
cord-259347-3acsko74	138	20	syndrome	syndrome	NN
cord-259347-3acsko74	139	1	Posttraumatic	posttraumatic	JJ
cord-259347-3acsko74	139	2	stress	stress	NN
cord-259347-3acsko74	139	3	,	,	,
cord-259347-3acsko74	139	4	anxiety	anxiety	NN
cord-259347-3acsko74	139	5	,	,	,
cord-259347-3acsko74	139	6	and	and	CC
cord-259347-3acsko74	139	7	depression	depression	NN
cord-259347-3acsko74	139	8	in	in	IN
cord-259347-3acsko74	139	9	survivors	survivor	NNS
cord-259347-3acsko74	139	10	of	of	IN
cord-259347-3acsko74	139	11	severe	severe	JJ
cord-259347-3acsko74	139	12	acute	acute	JJ
cord-259347-3acsko74	139	13	respiratory	respiratory	JJ
cord-259347-3acsko74	139	14	syndrome	syndrome	NN
cord-259347-3acsko74	139	15	(	(	-LRB-
cord-259347-3acsko74	139	16	SARS	SARS	NNP
cord-259347-3acsko74	139	17	)	)	-RRB-
cord-259347-3acsko74	140	1	Human	human	JJ
cord-259347-3acsko74	140	2	coronavirus	coronavirus	NN
cord-259347-3acsko74	140	3	OC43	OC43	NNP
cord-259347-3acsko74	140	4	infection	infection	NN
cord-259347-3acsko74	140	5	induces	induce	VBZ
cord-259347-3acsko74	140	6	chronic	chronic	JJ
cord-259347-3acsko74	140	7	encephalitis	encephalitis	RB
cord-259347-3acsko74	140	8	leading	lead	VBG
cord-259347-3acsko74	140	9	to	to	IN
cord-259347-3acsko74	140	10	disabilities	disability	NNS
cord-259347-3acsko74	140	11	in	in	IN
cord-259347-3acsko74	140	12	BALB	BALB	NNP
cord-259347-3acsko74	140	13	/	/	SYM
cord-259347-3acsko74	140	14	C	C	NNP
cord-259347-3acsko74	140	15	mice	mouse	NNS
cord-259347-3acsko74	141	1	Murine	Murine	NNP
cord-259347-3acsko74	141	2	Olfactory	Olfactory	NNP
cord-259347-3acsko74	141	3	Bulb	Bulb	NNP
cord-259347-3acsko74	141	4	Interneurons	Interneurons	NNPS
cord-259347-3acsko74	141	5	Survive	survive	VBP
cord-259347-3acsko74	141	6	Infection	infection	NN
cord-259347-3acsko74	141	7	with	with	IN
cord-259347-3acsko74	141	8	a	a	DT
cord-259347-3acsko74	141	9	Neurotropic	Neurotropic	NNP
cord-259347-3acsko74	141	10	Coronavirus	Coronavirus	NNP
cord-259347-3acsko74	141	11	Angiotensin	Angiotensin	NNP
cord-259347-3acsko74	141	12	-	-	HYPH
cord-259347-3acsko74	141	13	converting	convert	VBG
cord-259347-3acsko74	141	14	enzyme	enzyme	NN
cord-259347-3acsko74	141	15	2	2	CD
cord-259347-3acsko74	141	16	is	be	VBZ
cord-259347-3acsko74	141	17	a	a	DT
cord-259347-3acsko74	141	18	functional	functional	JJ
cord-259347-3acsko74	141	19	receptor	receptor	NN
cord-259347-3acsko74	141	20	for	for	IN
cord-259347-3acsko74	141	21	the	the	DT
cord-259347-3acsko74	141	22	SARS	SARS	NNP
cord-259347-3acsko74	141	23	coronavirus	coronavirus	NN
cord-259347-3acsko74	141	24	Expression	expression	NN
cord-259347-3acsko74	141	25	of	of	IN
cord-259347-3acsko74	141	26	elevated	elevated	JJ
cord-259347-3acsko74	141	27	levels	level	NNS
cord-259347-3acsko74	141	28	of	of	IN
cord-259347-3acsko74	141	29	pro	pro	JJ
cord-259347-3acsko74	141	30	-	-	JJ
cord-259347-3acsko74	141	31	inflammatory	inflammatory	JJ
cord-259347-3acsko74	141	32	cytokines	cytokine	NNS
cord-259347-3acsko74	141	33	in	in	IN
cord-259347-3acsko74	141	34	SARS	SARS	NNP
cord-259347-3acsko74	141	35	-	-	HYPH
cord-259347-3acsko74	141	36	CoV	CoV	NNP
cord-259347-3acsko74	141	37	-	-	HYPH
cord-259347-3acsko74	141	38	infected	infect	VBN
cord-259347-3acsko74	141	39	ACE2	ACE2	NNP
cord-259347-3acsko74	142	1	+	+	CC
cord-259347-3acsko74	142	2	cells	cell	NNS
cord-259347-3acsko74	142	3	in	in	IN
cord-259347-3acsko74	142	4	SARS	SARS	NNP
cord-259347-3acsko74	142	5	patients	patient	NNS
cord-259347-3acsko74	142	6	:	:	:
cord-259347-3acsko74	142	7	relation	relation	NN
cord-259347-3acsko74	142	8	to	to	IN
cord-259347-3acsko74	142	9	the	the	DT
cord-259347-3acsko74	142	10	acute	acute	JJ
cord-259347-3acsko74	142	11	lung	lung	NN
cord-259347-3acsko74	142	12	injury	injury	NN
cord-259347-3acsko74	142	13	and	and	CC
cord-259347-3acsko74	142	14	pathogenesis	pathogenesis	NN
cord-259347-3acsko74	142	15	of	of	IN
cord-259347-3acsko74	142	16	SARS	SARS	NNP
cord-259347-3acsko74	142	17	Tissue	Tissue	NNP
cord-259347-3acsko74	142	18	distribution	distribution	NN
cord-259347-3acsko74	142	19	of	of	IN
cord-259347-3acsko74	142	20	ACE2	ACE2	NNP
cord-259347-3acsko74	142	21	protein	protein	NN
cord-259347-3acsko74	142	22	,	,	,
cord-259347-3acsko74	142	23	the	the	DT
cord-259347-3acsko74	142	24	functional	functional	JJ
cord-259347-3acsko74	142	25	receptor	receptor	NN
cord-259347-3acsko74	142	26	for	for	IN
cord-259347-3acsko74	142	27	SARS	SARS	NNP
cord-259347-3acsko74	142	28	coronavirus	coronavirus	NN
cord-259347-3acsko74	142	29	.	.	.
cord-259347-3acsko74	143	1	A	a	DT
cord-259347-3acsko74	143	2	first	first	JJ
cord-259347-3acsko74	143	3	step	step	NN
cord-259347-3acsko74	143	4	in	in	IN
cord-259347-3acsko74	143	5	understanding	understand	VBG
cord-259347-3acsko74	143	6	SARS	SARS	NNP
cord-259347-3acsko74	143	7	pathogenesis	pathogenesis	NN
cord-259347-3acsko74	143	8	Tissue	tissue	NN
cord-259347-3acsko74	143	9	and	and	CC
cord-259347-3acsko74	143	10	cellular	cellular	JJ
cord-259347-3acsko74	143	11	tropism	tropism	NN
cord-259347-3acsko74	143	12	of	of	IN
cord-259347-3acsko74	143	13	the	the	DT
cord-259347-3acsko74	143	14	coronavirus	coronavirus	NN
cord-259347-3acsko74	143	15	associated	associate	VBN
cord-259347-3acsko74	143	16	with	with	IN
cord-259347-3acsko74	143	17	severe	severe	JJ
cord-259347-3acsko74	143	18	acute	acute	JJ
cord-259347-3acsko74	143	19	respiratory	respiratory	JJ
cord-259347-3acsko74	143	20	syndrome	syndrome	NN
cord-259347-3acsko74	143	21	:	:	:
cord-259347-3acsko74	143	22	an	an	DT
cord-259347-3acsko74	143	23	in	in	IN
cord-259347-3acsko74	143	24	-	-	HYPH
cord-259347-3acsko74	143	25	situ	situ	NN
cord-259347-3acsko74	143	26	hybridization	hybridization	NN
cord-259347-3acsko74	143	27	study	study	NN
cord-259347-3acsko74	143	28	of	of	IN
cord-259347-3acsko74	143	29	fatal	fatal	JJ
cord-259347-3acsko74	143	30	cases	case	NNS
cord-259347-3acsko74	144	1	Dipeptidyl	Dipeptidyl	NNP
cord-259347-3acsko74	144	2	peptidase	peptidase	NN
cord-259347-3acsko74	144	3	4	4	CD
cord-259347-3acsko74	144	4	is	be	VBZ
cord-259347-3acsko74	144	5	a	a	DT
cord-259347-3acsko74	144	6	functional	functional	JJ
cord-259347-3acsko74	144	7	receptor	receptor	NN
cord-259347-3acsko74	144	8	for	for	IN
cord-259347-3acsko74	144	9	the	the	DT
cord-259347-3acsko74	144	10	emerging	emerge	VBG
cord-259347-3acsko74	144	11	human	human	JJ
cord-259347-3acsko74	144	12	coronavirus	coronavirus	NN
cord-259347-3acsko74	144	13	-	-	HYPH
cord-259347-3acsko74	144	14	EMC	EMC	NNP
cord-259347-3acsko74	144	15	Dipeptidyl	Dipeptidyl	NNP
cord-259347-3acsko74	144	16	-	-	HYPH
cord-259347-3acsko74	144	17	peptidase	peptidase	NN
cord-259347-3acsko74	144	18	IV	IV	NNP
cord-259347-3acsko74	144	19	from	from	IN
cord-259347-3acsko74	144	20	bench	bench	NN
cord-259347-3acsko74	144	21	to	to	IN
cord-259347-3acsko74	144	22	bedside	bedside	NN
cord-259347-3acsko74	144	23	:	:	:
cord-259347-3acsko74	144	24	an	an	DT
cord-259347-3acsko74	144	25	update	update	NN
cord-259347-3acsko74	144	26	on	on	IN
cord-259347-3acsko74	144	27	structural	structural	JJ
cord-259347-3acsko74	144	28	properties	property	NNS
cord-259347-3acsko74	144	29	,	,	,
cord-259347-3acsko74	144	30	functions	function	NNS
cord-259347-3acsko74	144	31	,	,	,
cord-259347-3acsko74	144	32	and	and	CC
cord-259347-3acsko74	144	33	clinical	clinical	JJ
cord-259347-3acsko74	144	34	aspects	aspect	NNS
cord-259347-3acsko74	144	35	of	of	IN
cord-259347-3acsko74	144	36	the	the	DT
cord-259347-3acsko74	144	37	enzyme	enzyme	NN
cord-259347-3acsko74	144	38	DPP	DPP	NNP
cord-259347-3acsko74	144	39	IV	IV	NNP
cord-259347-3acsko74	144	40	Human	Human	NNP
cord-259347-3acsko74	144	41	aminopeptidase	aminopeptidase	NN
cord-259347-3acsko74	145	1	N	N	NNP
cord-259347-3acsko74	145	2	is	be	VBZ
cord-259347-3acsko74	145	3	a	a	DT
cord-259347-3acsko74	145	4	receptor	receptor	NN
cord-259347-3acsko74	145	5	for	for	IN
cord-259347-3acsko74	145	6	human	human	JJ
cord-259347-3acsko74	145	7	coronavirus	coronavirus	NN
cord-259347-3acsko74	145	8	229E	229e	CD
cord-259347-3acsko74	145	9	Aminopeptidase	Aminopeptidase	NNP
cord-259347-3acsko74	145	10	N	n	CD
cord-259347-3acsko74	145	11	inhibitors	inhibitor	NNS
cord-259347-3acsko74	145	12	and	and	CC
cord-259347-3acsko74	145	13	SARS	SARS	NNP
cord-259347-3acsko74	145	14	Involvement	Involvement	NNP
cord-259347-3acsko74	145	15	of	of	IN
cord-259347-3acsko74	145	16	aminopeptidase	aminopeptidase	NN
cord-259347-3acsko74	145	17	N	N	NNP
cord-259347-3acsko74	145	18	(	(	-LRB-
cord-259347-3acsko74	145	19	CD13	CD13	NNP
cord-259347-3acsko74	145	20	)	)	-RRB-
cord-259347-3acsko74	146	1	in	in	IN
cord-259347-3acsko74	146	2	infection	infection	NN
cord-259347-3acsko74	146	3	of	of	IN
cord-259347-3acsko74	146	4	human	human	JJ
cord-259347-3acsko74	146	5	neural	neural	JJ
cord-259347-3acsko74	146	6	cells	cell	NNS
cord-259347-3acsko74	146	7	by	by	IN
cord-259347-3acsko74	146	8	human	human	JJ
cord-259347-3acsko74	146	9	coronavirus	coronavirus	NN
cord-259347-3acsko74	146	10	229E	229e	CD
cord-259347-3acsko74	146	11	CD209L	CD209L	NNP
cord-259347-3acsko74	146	12	(	(	-LRB-
cord-259347-3acsko74	146	13	L	l	NN
cord-259347-3acsko74	146	14	-	-	HYPH
cord-259347-3acsko74	146	15	SIGN	SIGN	NNP
cord-259347-3acsko74	146	16	)	)	-RRB-
cord-259347-3acsko74	146	17	is	be	VBZ
cord-259347-3acsko74	146	18	a	a	DT
cord-259347-3acsko74	146	19	receptor	receptor	NN
cord-259347-3acsko74	146	20	for	for	IN
cord-259347-3acsko74	146	21	severe	severe	JJ
cord-259347-3acsko74	146	22	acute	acute	JJ
cord-259347-3acsko74	146	23	respiratory	respiratory	JJ
cord-259347-3acsko74	146	24	syndrome	syndrome	NN
cord-259347-3acsko74	146	25	coronavirus	coronavirus	NN
cord-259347-3acsko74	146	26	Inhibitors	Inhibitors	NNP
cord-259347-3acsko74	146	27	of	of	IN
cord-259347-3acsko74	146	28	cathepsin	cathepsin	NN
cord-259347-3acsko74	147	1	L	l	NN
cord-259347-3acsko74	147	2	prevent	prevent	VBP
cord-259347-3acsko74	147	3	severe	severe	JJ
cord-259347-3acsko74	147	4	acute	acute	JJ
cord-259347-3acsko74	147	5	respiratory	respiratory	JJ
cord-259347-3acsko74	147	6	syndrome	syndrome	NN
cord-259347-3acsko74	147	7	coronavirus	coronavirus	NN
cord-259347-3acsko74	147	8	entry	entry	NN
cord-259347-3acsko74	147	9	SARS	SARS	NNP
cord-259347-3acsko74	147	10	coronavirus	coronavirus	NN
cord-259347-3acsko74	147	11	,	,	,
cord-259347-3acsko74	147	12	but	but	CC
cord-259347-3acsko74	147	13	not	not	RB
cord-259347-3acsko74	147	14	human	human	JJ
cord-259347-3acsko74	147	15	coronavirus	coronavirus	NN
cord-259347-3acsko74	148	1	NL63	NL63	NNP
cord-259347-3acsko74	148	2	,	,	,
cord-259347-3acsko74	148	3	utilizes	utilize	VBZ
cord-259347-3acsko74	148	4	cathepsin	cathepsin	NN
cord-259347-3acsko74	148	5	L	l	NN
cord-259347-3acsko74	148	6	to	to	TO
cord-259347-3acsko74	148	7	infect	infect	VB
cord-259347-3acsko74	148	8	ACE2-expressing	ace2-expressing	NN
cord-259347-3acsko74	148	9	cells	cell	NNS
cord-259347-3acsko74	148	10	Dissemination	dissemination	NN
cord-259347-3acsko74	148	11	of	of	IN
cord-259347-3acsko74	148	12	MHV4	MHV4	NNP
cord-259347-3acsko74	148	13	(	(	-LRB-
cord-259347-3acsko74	148	14	strain	strain	NN
cord-259347-3acsko74	148	15	JHM	JHM	NNP
cord-259347-3acsko74	148	16	)	)	-RRB-
cord-259347-3acsko74	148	17	infection	infection	NN
cord-259347-3acsko74	148	18	does	do	VBZ
cord-259347-3acsko74	148	19	not	not	RB
cord-259347-3acsko74	148	20	require	require	VB
cord-259347-3acsko74	148	21	specific	specific	JJ
cord-259347-3acsko74	148	22	coronavirus	coronavirus	NN
cord-259347-3acsko74	148	23	receptors	receptor	NNS
cord-259347-3acsko74	148	24	Molecular	molecular	JJ
cord-259347-3acsko74	148	25	mechanism	mechanism	NN
cord-259347-3acsko74	148	26	for	for	IN
cord-259347-3acsko74	148	27	antibody	antibody	NN
cord-259347-3acsko74	148	28	-	-	HYPH
cord-259347-3acsko74	148	29	dependent	dependent	JJ
cord-259347-3acsko74	148	30	enhancement	enhancement	NN
cord-259347-3acsko74	148	31	of	of	IN
cord-259347-3acsko74	148	32	coronavirus	coronavirus	NN
cord-259347-3acsko74	148	33	entry	entry	NN
cord-259347-3acsko74	148	34	Antibodies	Antibodies	NNPS
cord-259347-3acsko74	148	35	against	against	IN
cord-259347-3acsko74	148	36	trimeric	trimeric	NNP
cord-259347-3acsko74	148	37	S	S	NNP
cord-259347-3acsko74	148	38	glycoprotein	glycoprotein	NN
cord-259347-3acsko74	148	39	protect	protect	VBP
cord-259347-3acsko74	148	40	hamsters	hamster	NNS
cord-259347-3acsko74	148	41	against	against	IN
cord-259347-3acsko74	148	42	SARS	SARS	NNP
cord-259347-3acsko74	148	43	-	-	HYPH
cord-259347-3acsko74	148	44	CoV	CoV	NNP
cord-259347-3acsko74	148	45	challenge	challenge	NN
cord-259347-3acsko74	148	46	despite	despite	IN
cord-259347-3acsko74	148	47	their	-PRON-	PRP$
cord-259347-3acsko74	148	48	capacity	capacity	NN
cord-259347-3acsko74	148	49	to	to	TO
cord-259347-3acsko74	148	50	mediate	mediate	VB
cord-259347-3acsko74	148	51	FcgammaRII	FcgammaRII	NNP
cord-259347-3acsko74	148	52	-	-	HYPH
cord-259347-3acsko74	148	53	dependent	dependent	JJ
cord-259347-3acsko74	148	54	entry	entry	NN
cord-259347-3acsko74	148	55	into	into	IN
cord-259347-3acsko74	148	56	B	b	NN
cord-259347-3acsko74	148	57	cells	cell	NNS
cord-259347-3acsko74	148	58	in	in	IN
cord-259347-3acsko74	148	59	vitro	vitro	FW
cord-259347-3acsko74	148	60	Pathological	pathological	JJ
cord-259347-3acsko74	148	61	findings	finding	NNS
cord-259347-3acsko74	148	62	of	of	IN
cord-259347-3acsko74	148	63	COVID-19	COVID-19	NNP
cord-259347-3acsko74	148	64	associated	associate	VBN
cord-259347-3acsko74	148	65	with	with	IN
cord-259347-3acsko74	148	66	acute	acute	JJ
cord-259347-3acsko74	148	67	respiratory	respiratory	JJ
cord-259347-3acsko74	148	68	distress	distress	NN
cord-259347-3acsko74	148	69	syndrome	syndrome	NN
cord-259347-3acsko74	148	70	Development	Development	NNP
cord-259347-3acsko74	148	71	and	and	CC
cord-259347-3acsko74	148	72	Clinical	Clinical	NNP
cord-259347-3acsko74	148	73	Application	Application	NNP
cord-259347-3acsko74	148	74	of	of	IN
cord-259347-3acsko74	148	75	A	a	DT
cord-259347-3acsko74	148	76	Rapid	Rapid	NNP
cord-259347-3acsko74	148	77	IgM	IgM	NNP
cord-259347-3acsko74	148	78	-	-	HYPH
cord-259347-3acsko74	148	79	IgG	IgG	NNP
cord-259347-3acsko74	148	80	Combined	Combined	NNP
cord-259347-3acsko74	148	81	Antibody	Antibody	NNP
cord-259347-3acsko74	148	82	Test	Test	NNP
cord-259347-3acsko74	148	83	for	for	IN
cord-259347-3acsko74	148	84	SARS	SARS	NNP
cord-259347-3acsko74	148	85	-	-	HYPH
cord-259347-3acsko74	148	86	CoV-2	CoV-2	NNP
cord-259347-3acsko74	148	87	Infection	infection	NN
cord-259347-3acsko74	148	88	Diagnosis	diagnosis	NN
cord-259347-3acsko74	149	1	The	the	DT
cord-259347-3acsko74	149	2	neuroinvasive	neuroinvasive	JJ
cord-259347-3acsko74	149	3	potential	potential	NN
cord-259347-3acsko74	149	4	of	of	IN
cord-259347-3acsko74	149	5	SARS	SARS	NNP
cord-259347-3acsko74	149	6	-	-	HYPH
cord-259347-3acsko74	149	7	CoV2	CoV2	NNP
cord-259347-3acsko74	149	8	may	may	MD
cord-259347-3acsko74	149	9	play	play	VB
cord-259347-3acsko74	149	10	a	a	DT
cord-259347-3acsko74	149	11	role	role	NN
cord-259347-3acsko74	149	12	in	in	IN
cord-259347-3acsko74	149	13	the	the	DT
cord-259347-3acsko74	149	14	respiratory	respiratory	JJ
cord-259347-3acsko74	149	15	failure	failure	NN
cord-259347-3acsko74	149	16	of	of	IN
cord-259347-3acsko74	149	17	COVID-19	covid-19	JJ
cord-259347-3acsko74	149	18	patients	patient	NNS
cord-259347-3acsko74	149	19	Neurologic	Neurologic	NNP
cord-259347-3acsko74	149	20	Features	Features	NNPS
cord-259347-3acsko74	149	21	in	in	IN
cord-259347-3acsko74	149	22	Severe	severe	JJ
cord-259347-3acsko74	149	23	SARS	SARS	NNP
cord-259347-3acsko74	149	24	-	-	HYPH
cord-259347-3acsko74	149	25	CoV-2	CoV-2	NNP
cord-259347-3acsko74	149	26	Infection	Infection	NNP
cord-259347-3acsko74	149	27	Sars	Sars	NNP
cord-259347-3acsko74	149	28	-	-	HYPH
cord-259347-3acsko74	149	29	Cov-2	Cov-2	NNP
cord-259347-3acsko74	149	30	:	:	:
cord-259347-3acsko74	149	31	underestimated	underestimate	VBN
cord-259347-3acsko74	149	32	damage	damage	NN
cord-259347-3acsko74	149	33	to	to	IN
cord-259347-3acsko74	149	34	nervous	nervous	JJ
cord-259347-3acsko74	149	35	system	system	NN
cord-259347-3acsko74	149	36	Non	non	JJ
cord-259347-3acsko74	149	37	-	-	JJ
cord-259347-3acsko74	149	38	neuronal	neuronal	JJ
cord-259347-3acsko74	149	39	expression	expression	NN
cord-259347-3acsko74	149	40	of	of	IN
cord-259347-3acsko74	149	41	SARS	SARS	NNP
cord-259347-3acsko74	149	42	-	-	HYPH
cord-259347-3acsko74	149	43	CoV-2	CoV-2	NNP
cord-259347-3acsko74	149	44	entry	entry	NN
cord-259347-3acsko74	149	45	genes	gene	NNS
cord-259347-3acsko74	149	46	in	in	IN
cord-259347-3acsko74	149	47	the	the	DT
cord-259347-3acsko74	149	48	olfactory	olfactory	JJ
cord-259347-3acsko74	149	49	system	system	NN
cord-259347-3acsko74	150	1	suggests	suggest	VBZ
cord-259347-3acsko74	150	2	mechanisms	mechanism	NNS
cord-259347-3acsko74	150	3	underlying	underlie	VBG
cord-259347-3acsko74	150	4	COVID-19-associated	covid-19-associated	JJ
cord-259347-3acsko74	150	5	anosmia	anosmia	NN
cord-259347-3acsko74	151	1	We	-PRON-	PRP
cord-259347-3acsko74	151	2	thank	thank	VBP
cord-259347-3acsko74	151	3	A	a	DT
cord-259347-3acsko74	151	4	/	/	SYM
cord-259347-3acsko74	151	5	Prof	Prof	NNP
cord-259347-3acsko74	151	6	Dennis	Dennis	NNP
cord-259347-3acsko74	151	7	Cordato	Cordato	NNP
cord-259347-3acsko74	151	8	,	,	,
cord-259347-3acsko74	151	9	Senior	Senior	NNP
cord-259347-3acsko74	151	10	Specialist	Specialist	NNP
cord-259347-3acsko74	151	11	/	/	SYM
cord-259347-3acsko74	151	12	Neurologist	Neurologist	NNP
cord-259347-3acsko74	151	13	,	,	,
cord-259347-3acsko74	151	14	Liverpool	Liverpool	NNP
cord-259347-3acsko74	151	15	Hospital	Hospital	NNP
cord-259347-3acsko74	151	16	,	,	,
cord-259347-3acsko74	151	17	Sydney	Sydney	NNP
cord-259347-3acsko74	151	18	,	,	,
cord-259347-3acsko74	151	19	Australia	Australia	NNP
cord-259347-3acsko74	151	20	,	,	,
cord-259347-3acsko74	151	21	for	for	IN
cord-259347-3acsko74	151	22	critical	critical	JJ
cord-259347-3acsko74	151	23	review	review	NN
cord-259347-3acsko74	151	24	and	and	CC
cord-259347-3acsko74	151	25	grammar	grammar	NN
cord-259347-3acsko74	151	26	check	check	NN
cord-259347-3acsko74	151	27	of	of	IN
cord-259347-3acsko74	151	28	the	the	DT
cord-259347-3acsko74	151	29	manuscript	manuscript	NN
cord-259347-3acsko74	151	30	.	.	.
cord-259347-3acsko74	152	1	We	-PRON-	PRP
cord-259347-3acsko74	152	2	received	receive	VBD
cord-259347-3acsko74	152	3	no	no	DT
cord-259347-3acsko74	152	4	funding	funding	NN
cord-259347-3acsko74	152	5	for	for	IN
cord-259347-3acsko74	152	6	this	this	DT
cord-259347-3acsko74	152	7	review	review	NN
cord-259347-3acsko74	152	8	.	.	.