id sid tid token lemma pos cord-256784-wfaqim7d 1 1 key key JJ cord-256784-wfaqim7d 2 1 : : : cord-256784-wfaqim7d 2 2 cord-256784-wfaqim7d cord-256784-wfaqim7d JJ cord-256784-wfaqim7d 2 3 authors author NNS cord-256784-wfaqim7d 2 4 : : : cord-256784-wfaqim7d 2 5 Modjarrad Modjarrad NNP cord-256784-wfaqim7d 2 6 , , , cord-256784-wfaqim7d 2 7 Kayvon Kayvon NNP cord-256784-wfaqim7d 2 8 title title NN cord-256784-wfaqim7d 2 9 : : : cord-256784-wfaqim7d 2 10 MERS MERS NNP cord-256784-wfaqim7d 2 11 - - HYPH cord-256784-wfaqim7d 2 12 CoV CoV NNP cord-256784-wfaqim7d 2 13 vaccine vaccine NN cord-256784-wfaqim7d 2 14 candidates candidate NNS cord-256784-wfaqim7d 2 15 in in IN cord-256784-wfaqim7d 2 16 development development NN cord-256784-wfaqim7d 2 17 : : : cord-256784-wfaqim7d 3 1 The the DT cord-256784-wfaqim7d 3 2 current current JJ cord-256784-wfaqim7d 3 3 landscape landscape NN cord-256784-wfaqim7d 3 4 date date NN cord-256784-wfaqim7d 3 5 : : : cord-256784-wfaqim7d 3 6 2016 2016 CD cord-256784-wfaqim7d 3 7 - - HYPH cord-256784-wfaqim7d 3 8 06 06 CD cord-256784-wfaqim7d 3 9 - - HYPH cord-256784-wfaqim7d 3 10 03 03 CD cord-256784-wfaqim7d 3 11 journal journal NN cord-256784-wfaqim7d 3 12 : : : cord-256784-wfaqim7d 4 1 Vaccine vaccine NN cord-256784-wfaqim7d 4 2 DOI DOI NNP cord-256784-wfaqim7d 4 3 : : : cord-256784-wfaqim7d 4 4 10.1016 10.1016 CD cord-256784-wfaqim7d 4 5 / / SYM cord-256784-wfaqim7d 4 6 j.vaccine.2016.03.104 j.vaccine.2016.03.104 NNP cord-256784-wfaqim7d 4 7 sha sha NNP cord-256784-wfaqim7d 4 8 : : : cord-256784-wfaqim7d 4 9 eb78c049ddae3d4769515ac771c1285446939f89 eb78c049ddae3d4769515ac771c1285446939f89 NFP cord-256784-wfaqim7d 4 10 doc_id doc_id CD cord-256784-wfaqim7d 4 11 : : : cord-256784-wfaqim7d 5 1 256784 256784 CD cord-256784-wfaqim7d 5 2 cord_uid cord_uid NNS cord-256784-wfaqim7d 5 3 : : : cord-256784-wfaqim7d 5 4 wfaqim7d wfaqim7d XX cord-256784-wfaqim7d 6 1 Middle Middle NNP cord-256784-wfaqim7d 6 2 East East NNP cord-256784-wfaqim7d 6 3 respiratory respiratory JJ cord-256784-wfaqim7d 6 4 syndrome syndrome NN cord-256784-wfaqim7d 6 5 coronavirus coronavirus NN cord-256784-wfaqim7d 6 6 ( ( -LRB- cord-256784-wfaqim7d 6 7 MERS MERS NNP cord-256784-wfaqim7d 6 8 - - HYPH cord-256784-wfaqim7d 6 9 CoV CoV NNP cord-256784-wfaqim7d 6 10 ) ) -RRB- cord-256784-wfaqim7d 6 11 , , , cord-256784-wfaqim7d 6 12 an an DT cord-256784-wfaqim7d 6 13 emerging emerge VBG cord-256784-wfaqim7d 6 14 infectious infectious JJ cord-256784-wfaqim7d 6 15 disease disease NN cord-256784-wfaqim7d 6 16 of of IN cord-256784-wfaqim7d 6 17 growing grow VBG cord-256784-wfaqim7d 6 18 global global JJ cord-256784-wfaqim7d 6 19 importance importance NN cord-256784-wfaqim7d 6 20 , , , cord-256784-wfaqim7d 6 21 has have VBZ cord-256784-wfaqim7d 6 22 caused cause VBN cord-256784-wfaqim7d 6 23 severe severe JJ cord-256784-wfaqim7d 6 24 acute acute JJ cord-256784-wfaqim7d 6 25 respiratory respiratory JJ cord-256784-wfaqim7d 6 26 disease disease NN cord-256784-wfaqim7d 6 27 in in IN cord-256784-wfaqim7d 6 28 more more JJR cord-256784-wfaqim7d 6 29 than than IN cord-256784-wfaqim7d 6 30 1600 1600 CD cord-256784-wfaqim7d 6 31 people people NNS cord-256784-wfaqim7d 6 32 , , , cord-256784-wfaqim7d 6 33 resulting result VBG cord-256784-wfaqim7d 6 34 in in IN cord-256784-wfaqim7d 6 35 more more JJR cord-256784-wfaqim7d 6 36 than than IN cord-256784-wfaqim7d 6 37 600 600 CD cord-256784-wfaqim7d 6 38 deaths death NNS cord-256784-wfaqim7d 6 39 . . . cord-256784-wfaqim7d 7 1 The the DT cord-256784-wfaqim7d 7 2 high high JJ cord-256784-wfaqim7d 7 3 case case NN cord-256784-wfaqim7d 7 4 fatality fatality NN cord-256784-wfaqim7d 7 5 rate rate NN cord-256784-wfaqim7d 7 6 , , , cord-256784-wfaqim7d 7 7 growing grow VBG cord-256784-wfaqim7d 7 8 geographic geographic JJ cord-256784-wfaqim7d 7 9 distribution distribution NN cord-256784-wfaqim7d 7 10 and and CC cord-256784-wfaqim7d 7 11 vaguely vaguely RB cord-256784-wfaqim7d 7 12 defined define VBN cord-256784-wfaqim7d 7 13 epidemiology epidemiology NN cord-256784-wfaqim7d 7 14 of of IN cord-256784-wfaqim7d 7 15 MERS MERS NNP cord-256784-wfaqim7d 7 16 - - HYPH cord-256784-wfaqim7d 7 17 CoV CoV NNP cord-256784-wfaqim7d 7 18 have have VBP cord-256784-wfaqim7d 7 19 created create VBN cord-256784-wfaqim7d 7 20 an an DT cord-256784-wfaqim7d 7 21 urgent urgent JJ cord-256784-wfaqim7d 7 22 need need NN cord-256784-wfaqim7d 7 23 for for IN cord-256784-wfaqim7d 7 24 effective effective JJ cord-256784-wfaqim7d 7 25 public public JJ cord-256784-wfaqim7d 7 26 health health NN cord-256784-wfaqim7d 7 27 countermeasures countermeasure NNS cord-256784-wfaqim7d 7 28 , , , cord-256784-wfaqim7d 7 29 paramount paramount NN cord-256784-wfaqim7d 7 30 of of IN cord-256784-wfaqim7d 7 31 which which WDT cord-256784-wfaqim7d 7 32 is be VBZ cord-256784-wfaqim7d 7 33 an an DT cord-256784-wfaqim7d 7 34 effective effective JJ cord-256784-wfaqim7d 7 35 means mean NNS cord-256784-wfaqim7d 7 36 of of IN cord-256784-wfaqim7d 7 37 prevention prevention NN cord-256784-wfaqim7d 7 38 through through IN cord-256784-wfaqim7d 7 39 a a DT cord-256784-wfaqim7d 7 40 vaccine vaccine NN cord-256784-wfaqim7d 7 41 or or CC cord-256784-wfaqim7d 7 42 antibody antibody NN cord-256784-wfaqim7d 7 43 prophylaxis prophylaxis NN cord-256784-wfaqim7d 7 44 . . . cord-256784-wfaqim7d 8 1 Despite despite IN cord-256784-wfaqim7d 8 2 the the DT cord-256784-wfaqim7d 8 3 relatively relatively RB cord-256784-wfaqim7d 8 4 few few JJ cord-256784-wfaqim7d 8 5 number number NN cord-256784-wfaqim7d 8 6 of of IN cord-256784-wfaqim7d 8 7 cases case NNS cord-256784-wfaqim7d 8 8 to to IN cord-256784-wfaqim7d 8 9 - - HYPH cord-256784-wfaqim7d 8 10 date date NN cord-256784-wfaqim7d 8 11 , , , cord-256784-wfaqim7d 8 12 research research NN cord-256784-wfaqim7d 8 13 and and CC cord-256784-wfaqim7d 8 14 development development NN cord-256784-wfaqim7d 8 15 of of IN cord-256784-wfaqim7d 8 16 MERS MERS NNP cord-256784-wfaqim7d 8 17 - - HYPH cord-256784-wfaqim7d 8 18 CoV CoV NNP cord-256784-wfaqim7d 8 19 vaccine vaccine NN cord-256784-wfaqim7d 8 20 candidates candidate NNS cord-256784-wfaqim7d 8 21 is be VBZ cord-256784-wfaqim7d 8 22 advancing advance VBG cord-256784-wfaqim7d 8 23 quickly quickly RB cord-256784-wfaqim7d 8 24 . . . cord-256784-wfaqim7d 9 1 This this DT cord-256784-wfaqim7d 9 2 review review NN cord-256784-wfaqim7d 9 3 surveys survey VBZ cord-256784-wfaqim7d 9 4 the the DT cord-256784-wfaqim7d 9 5 landscape landscape NN cord-256784-wfaqim7d 9 6 of of IN cord-256784-wfaqim7d 9 7 these these DT cord-256784-wfaqim7d 9 8 efforts effort NNS cord-256784-wfaqim7d 9 9 across across IN cord-256784-wfaqim7d 9 10 multiple multiple JJ cord-256784-wfaqim7d 9 11 groups group NNS cord-256784-wfaqim7d 9 12 in in IN cord-256784-wfaqim7d 9 13 academia academia NN cord-256784-wfaqim7d 9 14 , , , cord-256784-wfaqim7d 9 15 government government NN cord-256784-wfaqim7d 9 16 and and CC cord-256784-wfaqim7d 9 17 industry industry NN cord-256784-wfaqim7d 9 18 . . . cord-256784-wfaqim7d 10 1 Middle Middle NNP cord-256784-wfaqim7d 10 2 East East NNP cord-256784-wfaqim7d 10 3 Respiratory Respiratory NNP cord-256784-wfaqim7d 10 4 Syndrome Syndrome NNP cord-256784-wfaqim7d 10 5 ( ( -LRB- cord-256784-wfaqim7d 10 6 MERS MERS NNP cord-256784-wfaqim7d 10 7 - - HYPH cord-256784-wfaqim7d 10 8 CoV CoV NNP cord-256784-wfaqim7d 10 9 ) ) -RRB- cord-256784-wfaqim7d 10 10 was be VBD cord-256784-wfaqim7d 10 11 first first RB cord-256784-wfaqim7d 10 12 isolated isolate VBN cord-256784-wfaqim7d 10 13 in in IN cord-256784-wfaqim7d 10 14 September September NNP cord-256784-wfaqim7d 10 15 2012 2012 CD cord-256784-wfaqim7d 10 16 from from IN cord-256784-wfaqim7d 10 17 a a DT cord-256784-wfaqim7d 10 18 patient patient NN cord-256784-wfaqim7d 10 19 in in IN cord-256784-wfaqim7d 10 20 Saudi Saudi NNP cord-256784-wfaqim7d 10 21 Arabia Arabia NNP cord-256784-wfaqim7d 10 22 who who WP cord-256784-wfaqim7d 10 23 presented present VBD cord-256784-wfaqim7d 10 24 two two CD cord-256784-wfaqim7d 10 25 months month NNS cord-256784-wfaqim7d 10 26 earlier early RBR cord-256784-wfaqim7d 10 27 with with IN cord-256784-wfaqim7d 10 28 severe severe JJ cord-256784-wfaqim7d 10 29 acute acute JJ cord-256784-wfaqim7d 10 30 respiratory respiratory JJ cord-256784-wfaqim7d 10 31 infection infection NN cord-256784-wfaqim7d 10 32 and and CC cord-256784-wfaqim7d 10 33 acute acute JJ cord-256784-wfaqim7d 10 34 renal renal JJ cord-256784-wfaqim7d 10 35 failure failure NN cord-256784-wfaqim7d 10 36 [ [ -LRB- cord-256784-wfaqim7d 10 37 1 1 CD cord-256784-wfaqim7d 10 38 ] ] -RRB- cord-256784-wfaqim7d 10 39 . . . cord-256784-wfaqim7d 11 1 Retrospective retrospective JJ cord-256784-wfaqim7d 11 2 testing testing NN cord-256784-wfaqim7d 11 3 of of IN cord-256784-wfaqim7d 11 4 samples sample NNS cord-256784-wfaqim7d 11 5 in in IN cord-256784-wfaqim7d 11 6 Jordan Jordan NNP cord-256784-wfaqim7d 11 7 identified identify VBD cord-256784-wfaqim7d 11 8 earlier early JJR cord-256784-wfaqim7d 11 9 cases case NNS cord-256784-wfaqim7d 11 10 from from IN cord-256784-wfaqim7d 11 11 a a DT cord-256784-wfaqim7d 11 12 nosocomial nosocomial JJ cord-256784-wfaqim7d 11 13 outbreak outbreak NN cord-256784-wfaqim7d 11 14 in in IN cord-256784-wfaqim7d 11 15 April April NNP cord-256784-wfaqim7d 11 16 2012 2012 CD cord-256784-wfaqim7d 11 17 [ [ -LRB- cord-256784-wfaqim7d 11 18 2 2 CD cord-256784-wfaqim7d 11 19 ] ] -RRB- cord-256784-wfaqim7d 11 20 . . . cord-256784-wfaqim7d 12 1 Although although IN cord-256784-wfaqim7d 12 2 the the DT cord-256784-wfaqim7d 12 3 majority majority NN cord-256784-wfaqim7d 12 4 of of IN cord-256784-wfaqim7d 12 5 MERS MERS NNP cord-256784-wfaqim7d 12 6 - - HYPH cord-256784-wfaqim7d 12 7 CoV CoV NNP cord-256784-wfaqim7d 12 8 cases case NNS cord-256784-wfaqim7d 12 9 ( ( -LRB- cord-256784-wfaqim7d 12 10 ∼75 ∼75 NNP cord-256784-wfaqim7d 12 11 % % NN cord-256784-wfaqim7d 12 12 ) ) -RRB- cord-256784-wfaqim7d 12 13 have have VBP cord-256784-wfaqim7d 12 14 occurred occur VBN cord-256784-wfaqim7d 12 15 in in IN cord-256784-wfaqim7d 12 16 Saudi Saudi NNP cord-256784-wfaqim7d 12 17 Arabia Arabia NNP cord-256784-wfaqim7d 12 18 , , , cord-256784-wfaqim7d 12 19 25 25 CD cord-256784-wfaqim7d 12 20 other other JJ cord-256784-wfaqim7d 12 21 countries country NNS cord-256784-wfaqim7d 12 22 have have VBP cord-256784-wfaqim7d 12 23 confirmed confirm VBN cord-256784-wfaqim7d 12 24 imported import VBN cord-256784-wfaqim7d 12 25 or or CC cord-256784-wfaqim7d 12 26 autochthonously autochthonously RB cord-256784-wfaqim7d 12 27 transmitted transmit VBN cord-256784-wfaqim7d 12 28 cases case NNS cord-256784-wfaqim7d 13 1 ( ( -LRB- cord-256784-wfaqim7d 13 2 Fig Fig NNP cord-256784-wfaqim7d 13 3 . . . cord-256784-wfaqim7d 13 4 1 1 CD cord-256784-wfaqim7d 13 5 ) ) -RRB- cord-256784-wfaqim7d 13 6 [ [ -LRB- cord-256784-wfaqim7d 13 7 3 3 CD cord-256784-wfaqim7d 13 8 , , , cord-256784-wfaqim7d 13 9 4 4 CD cord-256784-wfaqim7d 13 10 ] ] -RRB- cord-256784-wfaqim7d 13 11 . . . cord-256784-wfaqim7d 14 1 The the DT cord-256784-wfaqim7d 14 2 most most RBS cord-256784-wfaqim7d 14 3 recent recent JJ cord-256784-wfaqim7d 14 4 and and CC cord-256784-wfaqim7d 14 5 largest large JJS cord-256784-wfaqim7d 14 6 outbreak outbreak NN cord-256784-wfaqim7d 14 7 outside outside IN cord-256784-wfaqim7d 14 8 of of IN cord-256784-wfaqim7d 14 9 Saudi Saudi NNP cord-256784-wfaqim7d 14 10 Arabia Arabia NNP cord-256784-wfaqim7d 14 11 occurred occur VBD cord-256784-wfaqim7d 14 12 in in IN cord-256784-wfaqim7d 14 13 South South NNP cord-256784-wfaqim7d 14 14 Korea Korea NNP cord-256784-wfaqim7d 14 15 in in IN cord-256784-wfaqim7d 14 16 May May NNP cord-256784-wfaqim7d 14 17 2015 2015 CD cord-256784-wfaqim7d 14 18 [ [ -LRB- cord-256784-wfaqim7d 14 19 5 5 CD cord-256784-wfaqim7d 14 20 ] ] -RRB- cord-256784-wfaqim7d 14 21 , , , cord-256784-wfaqim7d 14 22 raising raise VBG cord-256784-wfaqim7d 14 23 concern concern NN cord-256784-wfaqim7d 14 24 for for IN cord-256784-wfaqim7d 14 25 an an DT cord-256784-wfaqim7d 14 26 eruption eruption NN cord-256784-wfaqim7d 14 27 of of IN cord-256784-wfaqim7d 14 28 regional regional JJ cord-256784-wfaqim7d 14 29 outbreaks outbreak NNS cord-256784-wfaqim7d 14 30 or or CC cord-256784-wfaqim7d 14 31 accelerated accelerate VBN cord-256784-wfaqim7d 14 32 global global JJ cord-256784-wfaqim7d 14 33 spread spread NN cord-256784-wfaqim7d 14 34 , , , cord-256784-wfaqim7d 14 35 similar similar JJ cord-256784-wfaqim7d 14 36 to to IN cord-256784-wfaqim7d 14 37 the the DT cord-256784-wfaqim7d 14 38 phylogenetically phylogenetically RB cord-256784-wfaqim7d 14 39 related related JJ cord-256784-wfaqim7d 14 40 severe severe JJ cord-256784-wfaqim7d 14 41 acute acute JJ cord-256784-wfaqim7d 14 42 respiratory respiratory JJ cord-256784-wfaqim7d 14 43 syndrome syndrome NN cord-256784-wfaqim7d 14 44 coronavirus coronavirus NN cord-256784-wfaqim7d 14 45 ( ( -LRB- cord-256784-wfaqim7d 14 46 SARS SARS NNP cord-256784-wfaqim7d 14 47 - - HYPH cord-256784-wfaqim7d 14 48 CoV CoV NNP cord-256784-wfaqim7d 14 49 ) ) -RRB- cord-256784-wfaqim7d 14 50 that that WDT cord-256784-wfaqim7d 14 51 killed kill VBD cord-256784-wfaqim7d 14 52 nearly nearly RB cord-256784-wfaqim7d 14 53 a a DT cord-256784-wfaqim7d 14 54 thousand thousand CD cord-256784-wfaqim7d 14 55 people people NNS cord-256784-wfaqim7d 14 56 a a DT cord-256784-wfaqim7d 14 57 decade decade NN cord-256784-wfaqim7d 14 58 earlier early RBR cord-256784-wfaqim7d 14 59 [ [ -LRB- cord-256784-wfaqim7d 14 60 6 6 CD cord-256784-wfaqim7d 14 61 ] ] -RRB- cord-256784-wfaqim7d 14 62 . . . cord-256784-wfaqim7d 15 1 Although although IN cord-256784-wfaqim7d 15 2 the the DT cord-256784-wfaqim7d 15 3 definitive definitive JJ cord-256784-wfaqim7d 15 4 host host NN cord-256784-wfaqim7d 15 5 for for IN cord-256784-wfaqim7d 15 6 MERS MERS NNP cord-256784-wfaqim7d 15 7 - - HYPH cord-256784-wfaqim7d 15 8 CoV CoV NNP cord-256784-wfaqim7d 15 9 has have VBZ cord-256784-wfaqim7d 15 10 not not RB cord-256784-wfaqim7d 15 11 yet yet RB cord-256784-wfaqim7d 15 12 been be VBN cord-256784-wfaqim7d 15 13 established establish VBN cord-256784-wfaqim7d 15 14 , , , cord-256784-wfaqim7d 15 15 closely closely RB cord-256784-wfaqim7d 15 16 related relate VBN cord-256784-wfaqim7d 15 17 coronaviruses coronaviruse NNS cord-256784-wfaqim7d 15 18 have have VBP cord-256784-wfaqim7d 15 19 been be VBN cord-256784-wfaqim7d 15 20 isolated isolate VBN cord-256784-wfaqim7d 15 21 from from IN cord-256784-wfaqim7d 15 22 bats bat NNS cord-256784-wfaqim7d 15 23 across across IN cord-256784-wfaqim7d 15 24 wide wide JJ cord-256784-wfaqim7d 15 25 geographic geographic JJ cord-256784-wfaqim7d 15 26 areas area NNS cord-256784-wfaqim7d 15 27 [ [ -LRB- cord-256784-wfaqim7d 15 28 7 7 CD cord-256784-wfaqim7d 15 29 ] ] -RRB- cord-256784-wfaqim7d 15 30 [ [ -LRB- cord-256784-wfaqim7d 15 31 8 8 CD cord-256784-wfaqim7d 15 32 ] ] -RRB- cord-256784-wfaqim7d 15 33 [ [ -LRB- cord-256784-wfaqim7d 15 34 9 9 CD cord-256784-wfaqim7d 15 35 ] ] -RRB- cord-256784-wfaqim7d 15 36 . . . cord-256784-wfaqim7d 16 1 Mounting mount VBG cord-256784-wfaqim7d 16 2 evidence evidence NN cord-256784-wfaqim7d 16 3 has have VBZ cord-256784-wfaqim7d 16 4 strongly strongly RB cord-256784-wfaqim7d 16 5 implicated implicate VBN cord-256784-wfaqim7d 16 6 dromedary dromedary NN cord-256784-wfaqim7d 16 7 camels camel NNS cord-256784-wfaqim7d 16 8 as as IN cord-256784-wfaqim7d 16 9 the the DT cord-256784-wfaqim7d 16 10 intermediate intermediate JJ cord-256784-wfaqim7d 16 11 animal animal NN cord-256784-wfaqim7d 16 12 reservoir reservoir NN cord-256784-wfaqim7d 16 13 , , , cord-256784-wfaqim7d 16 14 as as IN cord-256784-wfaqim7d 16 15 serological serological JJ cord-256784-wfaqim7d 16 16 surveys survey NNS cord-256784-wfaqim7d 16 17 throughout throughout IN cord-256784-wfaqim7d 16 18 the the DT cord-256784-wfaqim7d 16 19 Middle Middle NNP cord-256784-wfaqim7d 16 20 East East NNP cord-256784-wfaqim7d 16 21 and and CC cord-256784-wfaqim7d 16 22 North North NNP cord-256784-wfaqim7d 16 23 Africa Africa NNP cord-256784-wfaqim7d 16 24 have have VBP cord-256784-wfaqim7d 16 25 demonstrated demonstrate VBN cord-256784-wfaqim7d 16 26 them -PRON- PRP cord-256784-wfaqim7d 16 27 to to TO cord-256784-wfaqim7d 16 28 have have VB cord-256784-wfaqim7d 16 29 a a DT cord-256784-wfaqim7d 16 30 high high JJ cord-256784-wfaqim7d 16 31 prevalence prevalence NN cord-256784-wfaqim7d 16 32 of of IN cord-256784-wfaqim7d 16 33 MERS MERS NNP cord-256784-wfaqim7d 16 34 - - HYPH cord-256784-wfaqim7d 16 35 CoV cov NN cord-256784-wfaqim7d 16 36 binding binding NN cord-256784-wfaqim7d 16 37 or or CC cord-256784-wfaqim7d 16 38 neutralizing neutralize VBG cord-256784-wfaqim7d 16 39 Abs Abs NNP cord-256784-wfaqim7d 16 40 [ [ -LRB- cord-256784-wfaqim7d 16 41 10 10 CD cord-256784-wfaqim7d 16 42 ] ] -RRB- cord-256784-wfaqim7d 16 43 [ [ -LRB- cord-256784-wfaqim7d 16 44 11 11 CD cord-256784-wfaqim7d 16 45 ] ] -RRB- cord-256784-wfaqim7d 16 46 [ [ -LRB- cord-256784-wfaqim7d 16 47 12 12 CD cord-256784-wfaqim7d 16 48 ] ] -RRB- cord-256784-wfaqim7d 16 49 [ [ -LRB- cord-256784-wfaqim7d 16 50 13 13 CD cord-256784-wfaqim7d 16 51 ] ] -RRB- cord-256784-wfaqim7d 16 52 . . . cord-256784-wfaqim7d 17 1 Additionally additionally RB cord-256784-wfaqim7d 17 2 , , , cord-256784-wfaqim7d 17 3 outbreak outbreak NN cord-256784-wfaqim7d 17 4 investigations investigation NNS cord-256784-wfaqim7d 17 5 have have VBP cord-256784-wfaqim7d 17 6 suggested suggest VBN cord-256784-wfaqim7d 17 7 epidemiologic epidemiologic JJ cord-256784-wfaqim7d 17 8 linkage linkage NN cord-256784-wfaqim7d 17 9 between between IN cord-256784-wfaqim7d 17 10 farm farm NN cord-256784-wfaqim7d 17 11 camels camel NNS cord-256784-wfaqim7d 17 12 and and CC cord-256784-wfaqim7d 17 13 human human JJ cord-256784-wfaqim7d 17 14 cases case NNS cord-256784-wfaqim7d 17 15 [ [ -LRB- cord-256784-wfaqim7d 17 16 14 14 CD cord-256784-wfaqim7d 17 17 ] ] -RRB- cord-256784-wfaqim7d 17 18 . . . cord-256784-wfaqim7d 18 1 MERS MERS NNP cord-256784-wfaqim7d 18 2 - - HYPH cord-256784-wfaqim7d 18 3 CoV CoV NNP cord-256784-wfaqim7d 18 4 is be VBZ cord-256784-wfaqim7d 18 5 a a DT cord-256784-wfaqim7d 18 6 spherical spherical JJ cord-256784-wfaqim7d 18 7 , , , cord-256784-wfaqim7d 18 8 enveloped envelop VBN cord-256784-wfaqim7d 18 9 , , , cord-256784-wfaqim7d 18 10 single single RB cord-256784-wfaqim7d 18 11 - - HYPH cord-256784-wfaqim7d 18 12 stranded stranded JJ cord-256784-wfaqim7d 18 13 , , , cord-256784-wfaqim7d 18 14 positive positive JJ cord-256784-wfaqim7d 18 15 sense sense NN cord-256784-wfaqim7d 19 1 RNA RNA NNP cord-256784-wfaqim7d 19 2 beta beta NN cord-256784-wfaqim7d 19 3 - - HYPH cord-256784-wfaqim7d 19 4 coronavirus coronavirus NN cord-256784-wfaqim7d 19 5 [ [ -LRB- cord-256784-wfaqim7d 19 6 1 1 CD cord-256784-wfaqim7d 19 7 , , , cord-256784-wfaqim7d 19 8 15 15 CD cord-256784-wfaqim7d 19 9 ] ] -RRB- cord-256784-wfaqim7d 19 10 . . . cord-256784-wfaqim7d 20 1 Its -PRON- PRP$ cord-256784-wfaqim7d 20 2 genome genome NN cord-256784-wfaqim7d 20 3 contains contain VBZ cord-256784-wfaqim7d 20 4 a a DT cord-256784-wfaqim7d 20 5 replicase replicase NN cord-256784-wfaqim7d 20 6 * * NFP cord-256784-wfaqim7d 20 7 Tel Tel NNP cord-256784-wfaqim7d 20 8 . . . cord-256784-wfaqim7d 20 9 : : : cord-256784-wfaqim7d 21 1 +13015003600 +13015003600 NNP cord-256784-wfaqim7d 21 2 . . . cord-256784-wfaqim7d 22 1 locus locus NN cord-256784-wfaqim7d 22 2 at at IN cord-256784-wfaqim7d 22 3 the the DT cord-256784-wfaqim7d 22 4 5 5 CD cord-256784-wfaqim7d 22 5 end end NN cord-256784-wfaqim7d 22 6 and and CC cord-256784-wfaqim7d 22 7 codes code NNS cord-256784-wfaqim7d 22 8 for for IN cord-256784-wfaqim7d 22 9 structural structural JJ cord-256784-wfaqim7d 22 10 proteins protein NNS cord-256784-wfaqim7d 22 11 toward toward IN cord-256784-wfaqim7d 22 12 the the DT cord-256784-wfaqim7d 22 13 3 3 CD cord-256784-wfaqim7d 22 14 end end NN cord-256784-wfaqim7d 22 15 . . . cord-256784-wfaqim7d 23 1 The the DT cord-256784-wfaqim7d 23 2 most most RBS cord-256784-wfaqim7d 23 3 immunogenic immunogenic JJ cord-256784-wfaqim7d 23 4 of of IN cord-256784-wfaqim7d 23 5 the the DT cord-256784-wfaqim7d 23 6 viral viral JJ cord-256784-wfaqim7d 23 7 proteins protein NNS cord-256784-wfaqim7d 23 8 is be VBZ cord-256784-wfaqim7d 23 9 Spike spike NN cord-256784-wfaqim7d 23 10 ( ( -LRB- cord-256784-wfaqim7d 23 11 S S NNP cord-256784-wfaqim7d 23 12 ) ) -RRB- cord-256784-wfaqim7d 23 13 , , , cord-256784-wfaqim7d 23 14 a a DT cord-256784-wfaqim7d 23 15 trimeric trimeric NN cord-256784-wfaqim7d 23 16 , , , cord-256784-wfaqim7d 23 17 envelope envelope NN cord-256784-wfaqim7d 23 18 - - HYPH cord-256784-wfaqim7d 23 19 anchored anchor VBN cord-256784-wfaqim7d 23 20 , , , cord-256784-wfaqim7d 23 21 type type NN cord-256784-wfaqim7d 23 22 I -PRON- PRP cord-256784-wfaqim7d 23 23 fusion fusion NN cord-256784-wfaqim7d 23 24 glycoprotein glycoprotein NN cord-256784-wfaqim7d 23 25 that that WDT cord-256784-wfaqim7d 23 26 interfaces interface NNS cord-256784-wfaqim7d 23 27 with with IN cord-256784-wfaqim7d 23 28 its -PRON- PRP$ cord-256784-wfaqim7d 23 29 human human JJ cord-256784-wfaqim7d 23 30 host host NN cord-256784-wfaqim7d 23 31 cognate cognate JJ cord-256784-wfaqim7d 23 32 receptor receptor NN cord-256784-wfaqim7d 23 33 , , , cord-256784-wfaqim7d 23 34 dipeptidyl dipeptidyl JJ cord-256784-wfaqim7d 23 35 peptidase peptidase NN cord-256784-wfaqim7d 23 36 4 4 CD cord-256784-wfaqim7d 23 37 ( ( -LRB- cord-256784-wfaqim7d 23 38 DPP4 DPP4 NNP cord-256784-wfaqim7d 23 39 ) ) -RRB- cord-256784-wfaqim7d 23 40 , , , cord-256784-wfaqim7d 23 41 to to TO cord-256784-wfaqim7d 23 42 mediate mediate VB cord-256784-wfaqim7d 23 43 viral viral JJ cord-256784-wfaqim7d 23 44 entry entry NN cord-256784-wfaqim7d 23 45 [ [ -LRB- cord-256784-wfaqim7d 23 46 16 16 CD cord-256784-wfaqim7d 23 47 , , , cord-256784-wfaqim7d 23 48 17 17 CD cord-256784-wfaqim7d 23 49 ] ] -RRB- cord-256784-wfaqim7d 23 50 . . . cord-256784-wfaqim7d 24 1 S S NNP cord-256784-wfaqim7d 24 2 comprises comprise VBZ cord-256784-wfaqim7d 24 3 two two CD cord-256784-wfaqim7d 24 4 subunits subunit NNS cord-256784-wfaqim7d 24 5 : : : cord-256784-wfaqim7d 24 6 S1 s1 NN cord-256784-wfaqim7d 24 7 , , , cord-256784-wfaqim7d 24 8 which which WDT cord-256784-wfaqim7d 24 9 contains contain VBZ cord-256784-wfaqim7d 24 10 the the DT cord-256784-wfaqim7d 24 11 receptor receptor NN cord-256784-wfaqim7d 24 12 - - HYPH cord-256784-wfaqim7d 24 13 binding bind VBG cord-256784-wfaqim7d 24 14 domain domain NN cord-256784-wfaqim7d 24 15 and and CC cord-256784-wfaqim7d 24 16 determines determine VBZ cord-256784-wfaqim7d 24 17 cell cell NN cord-256784-wfaqim7d 24 18 tropism tropism NN cord-256784-wfaqim7d 24 19 ; ; : cord-256784-wfaqim7d 24 20 and and CC cord-256784-wfaqim7d 24 21 S2 s2 NN cord-256784-wfaqim7d 24 22 , , , cord-256784-wfaqim7d 24 23 the the DT cord-256784-wfaqim7d 24 24 location location NN cord-256784-wfaqim7d 24 25 of of IN cord-256784-wfaqim7d 24 26 the the DT cord-256784-wfaqim7d 24 27 cell cell NN cord-256784-wfaqim7d 24 28 fusion fusion NN cord-256784-wfaqim7d 24 29 machinery machinery NN cord-256784-wfaqim7d 24 30 . . . cord-256784-wfaqim7d 25 1 Although although IN cord-256784-wfaqim7d 25 2 DPP4 DPP4 NNP cord-256784-wfaqim7d 25 3 has have VBZ cord-256784-wfaqim7d 25 4 a a DT cord-256784-wfaqim7d 25 5 broad broad JJ cord-256784-wfaqim7d 25 6 tissue tissue NN cord-256784-wfaqim7d 25 7 distribution distribution NN cord-256784-wfaqim7d 25 8 , , , cord-256784-wfaqim7d 25 9 most most JJS cord-256784-wfaqim7d 25 10 of of IN cord-256784-wfaqim7d 25 11 the the DT cord-256784-wfaqim7d 25 12 clinical clinical JJ cord-256784-wfaqim7d 25 13 manifestations manifestation NNS cord-256784-wfaqim7d 25 14 of of IN cord-256784-wfaqim7d 25 15 MERS MERS NNP cord-256784-wfaqim7d 25 16 - - HYPH cord-256784-wfaqim7d 25 17 CoV CoV NNP cord-256784-wfaqim7d 25 18 can can MD cord-256784-wfaqim7d 25 19 be be VB cord-256784-wfaqim7d 25 20 attributed attribute VBN cord-256784-wfaqim7d 25 21 to to IN cord-256784-wfaqim7d 25 22 its -PRON- PRP$ cord-256784-wfaqim7d 25 23 localization localization NN cord-256784-wfaqim7d 25 24 to to IN cord-256784-wfaqim7d 25 25 the the DT cord-256784-wfaqim7d 25 26 lower low JJR cord-256784-wfaqim7d 25 27 respiratory respiratory JJ cord-256784-wfaqim7d 25 28 tract tract NN cord-256784-wfaqim7d 25 29 [ [ -LRB- cord-256784-wfaqim7d 25 30 18 18 CD cord-256784-wfaqim7d 25 31 , , , cord-256784-wfaqim7d 25 32 19 19 CD cord-256784-wfaqim7d 25 33 ] ] -RRB- cord-256784-wfaqim7d 25 34 . . . cord-256784-wfaqim7d 26 1 Much much RB cord-256784-wfaqim7d 26 2 like like IN cord-256784-wfaqim7d 26 3 other other JJ cord-256784-wfaqim7d 26 4 coronaviruses coronaviruse NNS cord-256784-wfaqim7d 26 5 , , , cord-256784-wfaqim7d 26 6 MERS MERS NNP cord-256784-wfaqim7d 26 7 - - HYPH cord-256784-wfaqim7d 26 8 CoV CoV NNP cord-256784-wfaqim7d 26 9 can can MD cord-256784-wfaqim7d 26 10 also also RB cord-256784-wfaqim7d 26 11 cause cause VB cord-256784-wfaqim7d 26 12 significant significant JJ cord-256784-wfaqim7d 26 13 dysfunction dysfunction NN cord-256784-wfaqim7d 26 14 of of IN cord-256784-wfaqim7d 26 15 the the DT cord-256784-wfaqim7d 26 16 gastrointestinal gastrointestinal JJ cord-256784-wfaqim7d 26 17 , , , cord-256784-wfaqim7d 26 18 cardiovascular cardiovascular JJ cord-256784-wfaqim7d 26 19 , , , cord-256784-wfaqim7d 26 20 renal renal JJ cord-256784-wfaqim7d 26 21 , , , cord-256784-wfaqim7d 26 22 and and CC cord-256784-wfaqim7d 26 23 neurologic neurologic JJ cord-256784-wfaqim7d 26 24 systems system NNS cord-256784-wfaqim7d 26 25 . . . cord-256784-wfaqim7d 27 1 MERS MERS NNP cord-256784-wfaqim7d 27 2 - - HYPH cord-256784-wfaqim7d 27 3 CoV CoV NNP cord-256784-wfaqim7d 27 4 is be VBZ cord-256784-wfaqim7d 27 5 distinct distinct JJ cord-256784-wfaqim7d 27 6 , , , cord-256784-wfaqim7d 27 7 though though RB cord-256784-wfaqim7d 27 8 , , , cord-256784-wfaqim7d 27 9 in in IN cord-256784-wfaqim7d 27 10 its -PRON- PRP$ cord-256784-wfaqim7d 27 11 tendency tendency NN cord-256784-wfaqim7d 27 12 to to TO cord-256784-wfaqim7d 27 13 cause cause VB cord-256784-wfaqim7d 27 14 greatest great JJS cord-256784-wfaqim7d 27 15 harm harm NN cord-256784-wfaqim7d 27 16 to to IN cord-256784-wfaqim7d 27 17 older old JJR cord-256784-wfaqim7d 27 18 individuals individual NNS cord-256784-wfaqim7d 27 19 with with IN cord-256784-wfaqim7d 27 20 concurrent concurrent JJ cord-256784-wfaqim7d 27 21 comorbidities comorbiditie NNS cord-256784-wfaqim7d 27 22 of of IN cord-256784-wfaqim7d 27 23 one one CD cord-256784-wfaqim7d 27 24 or or CC cord-256784-wfaqim7d 27 25 more more JJR cord-256784-wfaqim7d 27 26 of of IN cord-256784-wfaqim7d 27 27 these these DT cord-256784-wfaqim7d 27 28 organ organ NN cord-256784-wfaqim7d 27 29 - - HYPH cord-256784-wfaqim7d 27 30 systems system NNS cord-256784-wfaqim7d 27 31 [ [ -LRB- cord-256784-wfaqim7d 27 32 20 20 CD cord-256784-wfaqim7d 27 33 , , , cord-256784-wfaqim7d 27 34 21 21 CD cord-256784-wfaqim7d 27 35 ] ] -RRB- cord-256784-wfaqim7d 27 36 . . . cord-256784-wfaqim7d 28 1 Despite despite IN cord-256784-wfaqim7d 28 2 past past JJ cord-256784-wfaqim7d 28 3 efforts effort NNS cord-256784-wfaqim7d 28 4 to to TO cord-256784-wfaqim7d 28 5 develop develop VB cord-256784-wfaqim7d 28 6 coronavirus coronavirus NN cord-256784-wfaqim7d 28 7 countermeasures countermeasure NNS cord-256784-wfaqim7d 28 8 in in IN cord-256784-wfaqim7d 28 9 response response NN cord-256784-wfaqim7d 28 10 to to IN cord-256784-wfaqim7d 28 11 the the DT cord-256784-wfaqim7d 28 12 SARS SARS NNP cord-256784-wfaqim7d 28 13 - - HYPH cord-256784-wfaqim7d 28 14 CoV CoV NNP cord-256784-wfaqim7d 28 15 pandemic pandemic NN cord-256784-wfaqim7d 28 16 , , , cord-256784-wfaqim7d 28 17 there there EX cord-256784-wfaqim7d 28 18 are be VBP cord-256784-wfaqim7d 28 19 currently currently RB cord-256784-wfaqim7d 28 20 no no DT cord-256784-wfaqim7d 28 21 prophylactic prophylactic JJ cord-256784-wfaqim7d 28 22 or or CC cord-256784-wfaqim7d 28 23 therapeutic therapeutic JJ cord-256784-wfaqim7d 28 24 interventions intervention NNS cord-256784-wfaqim7d 28 25 of of IN cord-256784-wfaqim7d 28 26 proven prove VBN cord-256784-wfaqim7d 28 27 efficacy efficacy NN cord-256784-wfaqim7d 28 28 for for IN cord-256784-wfaqim7d 28 29 MERS MERS NNP cord-256784-wfaqim7d 28 30 - - HYPH cord-256784-wfaqim7d 28 31 CoV CoV NNP cord-256784-wfaqim7d 28 32 or or CC cord-256784-wfaqim7d 28 33 any any DT cord-256784-wfaqim7d 28 34 other other JJ cord-256784-wfaqim7d 28 35 coronavirus coronavirus NN cord-256784-wfaqim7d 28 36 infection infection NN cord-256784-wfaqim7d 28 37 . . . cord-256784-wfaqim7d 29 1 Although although IN cord-256784-wfaqim7d 29 2 combination combination NN cord-256784-wfaqim7d 29 3 treatment treatment NN cord-256784-wfaqim7d 29 4 with with IN cord-256784-wfaqim7d 29 5 ribavirin ribavirin NN cord-256784-wfaqim7d 29 6 and and CC cord-256784-wfaqim7d 29 7 interferons interferon NNS cord-256784-wfaqim7d 29 8 were be VBD cord-256784-wfaqim7d 29 9 shown show VBN cord-256784-wfaqim7d 29 10 to to TO cord-256784-wfaqim7d 29 11 improve improve VB cord-256784-wfaqim7d 29 12 clinical clinical JJ cord-256784-wfaqim7d 29 13 outcomes outcome NNS cord-256784-wfaqim7d 29 14 in in IN cord-256784-wfaqim7d 29 15 MERS MERS NNP cord-256784-wfaqim7d 29 16 - - HYPH cord-256784-wfaqim7d 29 17 CoV CoV NNP cord-256784-wfaqim7d 29 18 - - HYPH cord-256784-wfaqim7d 29 19 infected infect VBN cord-256784-wfaqim7d 29 20 non non JJ cord-256784-wfaqim7d 29 21 - - JJ cord-256784-wfaqim7d 29 22 human human JJ cord-256784-wfaqim7d 29 23 primates primate NNS cord-256784-wfaqim7d 29 24 ( ( -LRB- cord-256784-wfaqim7d 29 25 NHPs NHPs NNP cord-256784-wfaqim7d 29 26 ) ) -RRB- cord-256784-wfaqim7d 29 27 , , , cord-256784-wfaqim7d 29 28 treatment treatment NN cord-256784-wfaqim7d 29 29 was be VBD cord-256784-wfaqim7d 29 30 initiated initiate VBN cord-256784-wfaqim7d 29 31 very very RB cord-256784-wfaqim7d 29 32 soon soon RB cord-256784-wfaqim7d 29 33 after after IN cord-256784-wfaqim7d 29 34 viral viral JJ cord-256784-wfaqim7d 29 35 challenge challenge NN cord-256784-wfaqim7d 29 36 ( ( -LRB- cord-256784-wfaqim7d 29 37 ∼8 ∼8 NNP cord-256784-wfaqim7d 29 38 h h NNP cord-256784-wfaqim7d 29 39 ) ) -RRB- cord-256784-wfaqim7d 29 40 and and CC cord-256784-wfaqim7d 29 41 results result NNS cord-256784-wfaqim7d 29 42 have have VBP cord-256784-wfaqim7d 29 43 not not RB cord-256784-wfaqim7d 29 44 been be VBN cord-256784-wfaqim7d 29 45 replicated replicate VBN cord-256784-wfaqim7d 29 46 in in IN cord-256784-wfaqim7d 29 47 humans human NNS cord-256784-wfaqim7d 29 48 [ [ -LRB- cord-256784-wfaqim7d 29 49 22 22 CD cord-256784-wfaqim7d 29 50 ] ] -RRB- cord-256784-wfaqim7d 29 51 . . . cord-256784-wfaqim7d 30 1 In in IN cord-256784-wfaqim7d 30 2 fact fact NN cord-256784-wfaqim7d 30 3 , , , cord-256784-wfaqim7d 30 4 no no DT cord-256784-wfaqim7d 30 5 experimental experimental JJ cord-256784-wfaqim7d 30 6 interventions intervention NNS cord-256784-wfaqim7d 30 7 have have VBP cord-256784-wfaqim7d 30 8 demonstrated demonstrate VBN cord-256784-wfaqim7d 30 9 appreciable appreciable JJ cord-256784-wfaqim7d 30 10 benefit benefit NN cord-256784-wfaqim7d 30 11 in in IN cord-256784-wfaqim7d 30 12 acutely acutely RB cord-256784-wfaqim7d 30 13 ill ill JJ cord-256784-wfaqim7d 30 14 patients patient NNS cord-256784-wfaqim7d 30 15 in in IN cord-256784-wfaqim7d 30 16 a a DT cord-256784-wfaqim7d 30 17 consistent consistent JJ cord-256784-wfaqim7d 30 18 or or CC cord-256784-wfaqim7d 30 19 controlled control VBN cord-256784-wfaqim7d 30 20 manner manner NN cord-256784-wfaqim7d 30 21 . . . cord-256784-wfaqim7d 31 1 Rapidly rapidly RB cord-256784-wfaqim7d 31 2 scaled scale VBN cord-256784-wfaqim7d 31 3 treatments treatment NNS cord-256784-wfaqim7d 31 4 based base VBN cord-256784-wfaqim7d 31 5 on on IN cord-256784-wfaqim7d 31 6 naturally naturally RB cord-256784-wfaqim7d 31 7 occurring occur VBG cord-256784-wfaqim7d 31 8 neutralizing neutralize VBG cord-256784-wfaqim7d 31 9 antibodies antibody NNS cord-256784-wfaqim7d 31 10 such such JJ cord-256784-wfaqim7d 31 11 as as IN cord-256784-wfaqim7d 31 12 convalescent convalescent JJ cord-256784-wfaqim7d 31 13 plasma plasma NN cord-256784-wfaqim7d 31 14 or or CC cord-256784-wfaqim7d 31 15 hyperimmune hyperimmune NNP cord-256784-wfaqim7d 31 16 globulin globulin NNP cord-256784-wfaqim7d 31 17 , , , cord-256784-wfaqim7d 31 18 on on IN cord-256784-wfaqim7d 31 19 the the DT cord-256784-wfaqim7d 31 20 other other JJ cord-256784-wfaqim7d 31 21 hand hand NN cord-256784-wfaqim7d 31 22 , , , cord-256784-wfaqim7d 31 23 have have VBP cord-256784-wfaqim7d 31 24 demonstrated demonstrate VBN cord-256784-wfaqim7d 31 25 mortality mortality NN cord-256784-wfaqim7d 31 26 reductions reduction NNS cord-256784-wfaqim7d 31 27 for for IN cord-256784-wfaqim7d 31 28 other other JJ cord-256784-wfaqim7d 31 29 respiratory respiratory JJ cord-256784-wfaqim7d 31 30 infections infection NNS cord-256784-wfaqim7d 31 31 and and CC cord-256784-wfaqim7d 31 32 may may MD cord-256784-wfaqim7d 31 33 hold hold VB cord-256784-wfaqim7d 31 34 promise promise NN cord-256784-wfaqim7d 31 35 for for IN cord-256784-wfaqim7d 31 36 MERS MERS NNP cord-256784-wfaqim7d 31 37 - - HYPH cord-256784-wfaqim7d 31 38 CoV CoV NNP cord-256784-wfaqim7d 31 39 as as RB cord-256784-wfaqim7d 31 40 well well RB cord-256784-wfaqim7d 31 41 [ [ -LRB- cord-256784-wfaqim7d 31 42 23 23 CD cord-256784-wfaqim7d 31 43 ] ] -RRB- cord-256784-wfaqim7d 31 44 . . . cord-256784-wfaqim7d 32 1 Their -PRON- PRP$ cord-256784-wfaqim7d 32 2 development development NN cord-256784-wfaqim7d 32 3 , , , cord-256784-wfaqim7d 32 4 however however RB cord-256784-wfaqim7d 32 5 , , , cord-256784-wfaqim7d 32 6 is be VBZ cord-256784-wfaqim7d 32 7 limited limit VBN cord-256784-wfaqim7d 32 8 by by IN cord-256784-wfaqim7d 32 9 logistical logistical JJ cord-256784-wfaqim7d 32 10 challenges challenge NNS cord-256784-wfaqim7d 32 11 , , , cord-256784-wfaqim7d 32 12 local local JJ cord-256784-wfaqim7d 32 13 technical technical JJ cord-256784-wfaqim7d 32 14 capacity capacity NN cord-256784-wfaqim7d 32 15 , , , cord-256784-wfaqim7d 32 16 and and CC cord-256784-wfaqim7d 32 17 donor donor NN cord-256784-wfaqim7d 32 18 supply supply NN cord-256784-wfaqim7d 32 19 . . . cord-256784-wfaqim7d 33 1 Supportive supportive JJ cord-256784-wfaqim7d 33 2 management management NN cord-256784-wfaqim7d 33 3 , , , cord-256784-wfaqim7d 33 4 adapted adapt VBN cord-256784-wfaqim7d 33 5 from from IN cord-256784-wfaqim7d 33 6 guidelines guideline NNS cord-256784-wfaqim7d 33 7 developed develop VBN cord-256784-wfaqim7d 33 8 for for IN cord-256784-wfaqim7d 33 9 SARS SARS NNP cord-256784-wfaqim7d 33 10 - - HYPH cord-256784-wfaqim7d 33 11 CoV CoV NNP cord-256784-wfaqim7d 33 12 , , , cord-256784-wfaqim7d 33 13 has have VBZ cord-256784-wfaqim7d 33 14 thus thus RB cord-256784-wfaqim7d 33 15 far far RB cord-256784-wfaqim7d 33 16 been be VBN cord-256784-wfaqim7d 33 17 the the DT cord-256784-wfaqim7d 33 18 mainstay mainstay NN cord-256784-wfaqim7d 33 19 of of IN cord-256784-wfaqim7d 33 20 MERS MERS NNP cord-256784-wfaqim7d 33 21 - - HYPH cord-256784-wfaqim7d 33 22 CoV CoV NNP cord-256784-wfaqim7d 33 23 treatment treatment NN cord-256784-wfaqim7d 33 24 . . . cord-256784-wfaqim7d 34 1 The the DT cord-256784-wfaqim7d 34 2 global global JJ cord-256784-wfaqim7d 34 3 will will NN cord-256784-wfaqim7d 34 4 to to TO cord-256784-wfaqim7d 34 5 develop develop VB cord-256784-wfaqim7d 34 6 a a DT cord-256784-wfaqim7d 34 7 coronavirus coronavirus NN cord-256784-wfaqim7d 34 8 vaccine vaccine NN cord-256784-wfaqim7d 34 9 faded fade VBD cord-256784-wfaqim7d 34 10 in in IN cord-256784-wfaqim7d 34 11 the the DT cord-256784-wfaqim7d 34 12 aftermath aftermath NN cord-256784-wfaqim7d 34 13 of of IN cord-256784-wfaqim7d 34 14 SARS SARS NNP cord-256784-wfaqim7d 34 15 - - HYPH cord-256784-wfaqim7d 34 16 CoV CoV NNP cord-256784-wfaqim7d 34 17 pandemic pandemic NN cord-256784-wfaqim7d 34 18 but but CC cord-256784-wfaqim7d 34 19 has have VBZ cord-256784-wfaqim7d 34 20 since since IN cord-256784-wfaqim7d 34 21 gained gain VBN cord-256784-wfaqim7d 34 22 renewed renew VBN cord-256784-wfaqim7d 34 23 momentum momentum NN cord-256784-wfaqim7d 34 24 in in IN cord-256784-wfaqim7d 34 25 the the DT cord-256784-wfaqim7d 34 26 face face NN cord-256784-wfaqim7d 34 27 of of IN cord-256784-wfaqim7d 34 28 the the DT cord-256784-wfaqim7d 34 29 current current JJ cord-256784-wfaqim7d 34 30 MERS MERS NNP cord-256784-wfaqim7d 34 31 - - HYPH cord-256784-wfaqim7d 34 32 CoV CoV NNP cord-256784-wfaqim7d 34 33 outbreak outbreak NN cord-256784-wfaqim7d 34 34 . . . cord-256784-wfaqim7d 35 1 Previous previous JJ cord-256784-wfaqim7d 35 2 approaches approach NNS cord-256784-wfaqim7d 35 3 to to IN cord-256784-wfaqim7d 35 4 coronavirus coronavirus NN cord-256784-wfaqim7d 35 5 vaccine vaccine NN cord-256784-wfaqim7d 35 6 development development NN cord-256784-wfaqim7d 35 7 were be VBD cord-256784-wfaqim7d 35 8 broad broad JJ cord-256784-wfaqim7d 35 9 and and CC cord-256784-wfaqim7d 35 10 included include VBD cord-256784-wfaqim7d 35 11 whole whole RB cord-256784-wfaqim7d 35 12 - - HYPH cord-256784-wfaqim7d 35 13 inactivated inactivated JJ cord-256784-wfaqim7d 35 14 and and CC cord-256784-wfaqim7d 35 15 live live RB cord-256784-wfaqim7d 35 16 - - HYPH cord-256784-wfaqim7d 35 17 attenuated attenuate VBN cord-256784-wfaqim7d 35 18 viruses virus NNS cord-256784-wfaqim7d 35 19 , , , cord-256784-wfaqim7d 35 20 recombinant recombinant JJ cord-256784-wfaqim7d 35 21 vectors vector NNS cord-256784-wfaqim7d 35 22 and and CC cord-256784-wfaqim7d 35 23 protein protein NN cord-256784-wfaqim7d 35 24 subunits subunit NNS cord-256784-wfaqim7d 35 25 , , , cord-256784-wfaqim7d 35 26 as as RB cord-256784-wfaqim7d 35 27 well well RB cord-256784-wfaqim7d 35 28 as as IN cord-256784-wfaqim7d 35 29 DNA DNA NNP cord-256784-wfaqim7d 35 30 and and CC cord-256784-wfaqim7d 35 31 RNA RNA NNP cord-256784-wfaqim7d 35 32 based base VBN cord-256784-wfaqim7d 35 33 platforms platform NNS cord-256784-wfaqim7d 35 34 [ [ -LRB- cord-256784-wfaqim7d 35 35 6 6 CD cord-256784-wfaqim7d 35 36 ] ] -RRB- cord-256784-wfaqim7d 35 37 . . . cord-256784-wfaqim7d 36 1 Most Most JJS cord-256784-wfaqim7d 36 2 developers developer NNS cord-256784-wfaqim7d 36 3 based base VBD cord-256784-wfaqim7d 36 4 their -PRON- PRP$ cord-256784-wfaqim7d 36 5 immunogen immunogen NN cord-256784-wfaqim7d 36 6 designs design NNS cord-256784-wfaqim7d 36 7 on on IN cord-256784-wfaqim7d 36 8 the the DT cord-256784-wfaqim7d 36 9 S S NNP cord-256784-wfaqim7d 36 10 surface surface NN cord-256784-wfaqim7d 36 11 glycoprotein glycoprotein NN cord-256784-wfaqim7d 36 12 , , , cord-256784-wfaqim7d 36 13 the the DT cord-256784-wfaqim7d 36 14 primary primary JJ cord-256784-wfaqim7d 36 15 target target NN cord-256784-wfaqim7d 36 16 for for IN cord-256784-wfaqim7d 36 17 neutralizing neutralize VBG cord-256784-wfaqim7d 36 18 antibodies antibody NNS cord-256784-wfaqim7d 36 19 during during IN cord-256784-wfaqim7d 36 20 any any DT cord-256784-wfaqim7d 36 21 natural natural JJ cord-256784-wfaqim7d 36 22 coronavirus coronavirus NN cord-256784-wfaqim7d 36 23 infection infection NN cord-256784-wfaqim7d 36 24 . . . cord-256784-wfaqim7d 37 1 A a DT cord-256784-wfaqim7d 37 2 number number NN cord-256784-wfaqim7d 37 3 of of IN cord-256784-wfaqim7d 37 4 preclinical preclinical JJ cord-256784-wfaqim7d 37 5 and and CC cord-256784-wfaqim7d 37 6 clinical clinical JJ cord-256784-wfaqim7d 37 7 studies study NNS cord-256784-wfaqim7d 37 8 showed show VBD cord-256784-wfaqim7d 37 9 that that IN cord-256784-wfaqim7d 37 10 the the DT cord-256784-wfaqim7d 37 11 SARS SARS NNP cord-256784-wfaqim7d 37 12 - - HYPH cord-256784-wfaqim7d 37 13 CoV CoV NNP cord-256784-wfaqim7d 37 14 S1 S1 NNP cord-256784-wfaqim7d 37 15 protein protein NN cord-256784-wfaqim7d 37 16 subunit subunit NN cord-256784-wfaqim7d 37 17 , , , cord-256784-wfaqim7d 37 18 and and CC cord-256784-wfaqim7d 37 19 specifically specifically RB cord-256784-wfaqim7d 37 20 the the DT cord-256784-wfaqim7d 37 21 RBD RBD NNP cord-256784-wfaqim7d 37 22 at at IN cord-256784-wfaqim7d 37 23 its -PRON- PRP$ cord-256784-wfaqim7d 37 24 core core NN cord-256784-wfaqim7d 37 25 , , , cord-256784-wfaqim7d 37 26 could could MD cord-256784-wfaqim7d 37 27 serve serve VB cord-256784-wfaqim7d 37 28 as as IN cord-256784-wfaqim7d 37 29 a a DT cord-256784-wfaqim7d 37 30 dominant dominant JJ cord-256784-wfaqim7d 37 31 target target NN cord-256784-wfaqim7d 37 32 for for IN cord-256784-wfaqim7d 37 33 neutralizing neutralize VBG cord-256784-wfaqim7d 37 34 antibodies antibody NNS cord-256784-wfaqim7d 37 35 in in IN cord-256784-wfaqim7d 37 36 mice mouse NNS cord-256784-wfaqim7d 37 37 , , , cord-256784-wfaqim7d 37 38 non non JJ cord-256784-wfaqim7d 37 39 - - JJ cord-256784-wfaqim7d 37 40 human human JJ cord-256784-wfaqim7d 37 41 primates primate NNS cord-256784-wfaqim7d 37 42 , , , cord-256784-wfaqim7d 37 43 and and CC cord-256784-wfaqim7d 37 44 humans human NNS cord-256784-wfaqim7d 37 45 [ [ -LRB- cord-256784-wfaqim7d 37 46 24 24 CD cord-256784-wfaqim7d 37 47 ] ] -RRB- cord-256784-wfaqim7d 37 48 . . . cord-256784-wfaqim7d 38 1 S1 s1 NN cord-256784-wfaqim7d 38 2 , , , cord-256784-wfaqim7d 38 3 therefore therefore RB cord-256784-wfaqim7d 38 4 , , , cord-256784-wfaqim7d 38 5 became become VBD cord-256784-wfaqim7d 38 6 the the DT cord-256784-wfaqim7d 38 7 basis basis NN cord-256784-wfaqim7d 38 8 for for IN cord-256784-wfaqim7d 38 9 a a DT cord-256784-wfaqim7d 38 10 number number NN cord-256784-wfaqim7d 38 11 of of IN cord-256784-wfaqim7d 38 12 promising promise VBG cord-256784-wfaqim7d 38 13 SARS SARS NNP cord-256784-wfaqim7d 38 14 - - HYPH cord-256784-wfaqim7d 38 15 CoV CoV NNP cord-256784-wfaqim7d 38 16 vaccine vaccine NN cord-256784-wfaqim7d 38 17 candidates candidate NNS cord-256784-wfaqim7d 38 18 . . . cord-256784-wfaqim7d 39 1 The the DT cord-256784-wfaqim7d 39 2 S1 S1 NNP cord-256784-wfaqim7d 39 3 protein protein NN cord-256784-wfaqim7d 39 4 subunit subunit NN cord-256784-wfaqim7d 39 5 and and CC cord-256784-wfaqim7d 39 6 RBD RBD NNP cord-256784-wfaqim7d 39 7 have have VBP cord-256784-wfaqim7d 39 8 also also RB cord-256784-wfaqim7d 39 9 been be VBN cord-256784-wfaqim7d 39 10 the the DT cord-256784-wfaqim7d 39 11 basis basis NN cord-256784-wfaqim7d 39 12 for for IN cord-256784-wfaqim7d 39 13 several several JJ cord-256784-wfaqim7d 39 14 MERS MERS NNP cord-256784-wfaqim7d 39 15 - - HYPH cord-256784-wfaqim7d 39 16 CoV CoV NNP cord-256784-wfaqim7d 39 17 vaccine vaccine NN cord-256784-wfaqim7d 39 18 candidates candidate NNS cord-256784-wfaqim7d 39 19 ( ( -LRB- cord-256784-wfaqim7d 39 20 Fig Fig NNP cord-256784-wfaqim7d 39 21 . . NNP cord-256784-wfaqim7d 39 22 2 2 CD cord-256784-wfaqim7d 39 23 ) ) -RRB- cord-256784-wfaqim7d 40 1 [ [ -LRB- cord-256784-wfaqim7d 40 2 25 25 CD cord-256784-wfaqim7d 40 3 ] ] -RRB- cord-256784-wfaqim7d 40 4 [ [ -LRB- cord-256784-wfaqim7d 40 5 26 26 CD cord-256784-wfaqim7d 40 6 ] ] -RRB- cord-256784-wfaqim7d 40 7 [ [ -LRB- cord-256784-wfaqim7d 40 8 27 27 CD cord-256784-wfaqim7d 40 9 ] ] -RRB- cord-256784-wfaqim7d 41 1 [ [ -LRB- cord-256784-wfaqim7d 41 2 28 28 CD cord-256784-wfaqim7d 41 3 ] ] -RRB- cord-256784-wfaqim7d 41 4 [ [ -LRB- cord-256784-wfaqim7d 41 5 29 29 CD cord-256784-wfaqim7d 41 6 ] ] -RRB- cord-256784-wfaqim7d 41 7 . . . cord-256784-wfaqim7d 42 1 Resolution resolution NN cord-256784-wfaqim7d 42 2 of of IN cord-256784-wfaqim7d 42 3 RBD RBD NNP cord-256784-wfaqim7d 42 4 crystal crystal NN cord-256784-wfaqim7d 42 5 structures structure NNS cord-256784-wfaqim7d 42 6 alone alone RB cord-256784-wfaqim7d 42 7 or or CC cord-256784-wfaqim7d 42 8 in in IN cord-256784-wfaqim7d 42 9 complex complex NN cord-256784-wfaqim7d 42 10 with with IN cord-256784-wfaqim7d 42 11 the the DT cord-256784-wfaqim7d 42 12 DPP4 DPP4 NNP cord-256784-wfaqim7d 42 13 receptor receptor NN cord-256784-wfaqim7d 42 14 [ [ -LRB- cord-256784-wfaqim7d 42 15 25 25 CD cord-256784-wfaqim7d 42 16 , , , cord-256784-wfaqim7d 42 17 30 30 CD cord-256784-wfaqim7d 42 18 , , , cord-256784-wfaqim7d 42 19 31 31 CD cord-256784-wfaqim7d 42 20 ] ] -RRB- cord-256784-wfaqim7d 42 21 have have VBP cord-256784-wfaqim7d 42 22 informed inform VBN cord-256784-wfaqim7d 42 23 the the DT cord-256784-wfaqim7d 42 24 design design NN cord-256784-wfaqim7d 42 25 of of IN cord-256784-wfaqim7d 42 26 immunogens immunogen NNS cord-256784-wfaqim7d 42 27 that that WDT cord-256784-wfaqim7d 42 28 have have VBP cord-256784-wfaqim7d 42 29 been be VBN cord-256784-wfaqim7d 42 30 expressed express VBN cord-256784-wfaqim7d 42 31 either either CC cord-256784-wfaqim7d 42 32 as as IN cord-256784-wfaqim7d 42 33 recombinant recombinant JJ cord-256784-wfaqim7d 42 34 protein protein NN cord-256784-wfaqim7d 42 35 fragments fragment NNS cord-256784-wfaqim7d 42 36 or or CC cord-256784-wfaqim7d 42 37 conjugates conjugate NNS cord-256784-wfaqim7d 42 38 to to IN cord-256784-wfaqim7d 42 39 the the DT cord-256784-wfaqim7d 42 40 fragment fragment NN cord-256784-wfaqim7d 42 41 crystallizable crystallizable NN cord-256784-wfaqim7d 42 42 ( ( -LRB- cord-256784-wfaqim7d 42 43 Fc Fc NNP cord-256784-wfaqim7d 42 44 ) ) -RRB- cord-256784-wfaqim7d 42 45 region region NN cord-256784-wfaqim7d 42 46 of of IN cord-256784-wfaqim7d 42 47 human human JJ cord-256784-wfaqim7d 42 48 antibodies antibody NNS cord-256784-wfaqim7d 42 49 . . . cord-256784-wfaqim7d 43 1 Both both DT cord-256784-wfaqim7d 43 2 types type NNS cord-256784-wfaqim7d 43 3 of of IN cord-256784-wfaqim7d 43 4 constructs construct NNS cord-256784-wfaqim7d 43 5 , , , cord-256784-wfaqim7d 43 6 in in IN cord-256784-wfaqim7d 43 7 formulation formulation NN cord-256784-wfaqim7d 43 8 with with IN cord-256784-wfaqim7d 43 9 aluminum aluminum NN cord-256784-wfaqim7d 43 10 salt salt NN cord-256784-wfaqim7d 43 11 or or CC cord-256784-wfaqim7d 43 12 oil oil NN cord-256784-wfaqim7d 43 13 - - HYPH cord-256784-wfaqim7d 43 14 in in IN cord-256784-wfaqim7d 43 15 - - HYPH cord-256784-wfaqim7d 43 16 water water NN cord-256784-wfaqim7d 43 17 adjuvants adjuvant NNS cord-256784-wfaqim7d 43 18 , , , cord-256784-wfaqim7d 43 19 have have VBP cord-256784-wfaqim7d 43 20 elicited elicit VBN cord-256784-wfaqim7d 43 21 neutralizing neutralize VBG cord-256784-wfaqim7d 43 22 antibodies antibody NNS cord-256784-wfaqim7d 43 23 of of IN cord-256784-wfaqim7d 43 24 high high JJ cord-256784-wfaqim7d 43 25 potency potency NN cord-256784-wfaqim7d 43 26 across across IN cord-256784-wfaqim7d 43 27 multiple multiple JJ cord-256784-wfaqim7d 43 28 viral viral JJ cord-256784-wfaqim7d 43 29 strains strain NNS cord-256784-wfaqim7d 43 30 . . . cord-256784-wfaqim7d 44 1 Despite despite IN cord-256784-wfaqim7d 44 2 their -PRON- PRP$ cord-256784-wfaqim7d 44 3 demonstrated demonstrate VBN cord-256784-wfaqim7d 44 4 immunogenicity immunogenicity NN cord-256784-wfaqim7d 44 5 in in IN cord-256784-wfaqim7d 44 6 animal animal NN cord-256784-wfaqim7d 44 7 models model NNS cord-256784-wfaqim7d 44 8 and and CC cord-256784-wfaqim7d 44 9 anticipated anticipate VBN cord-256784-wfaqim7d 44 10 safety safety NN cord-256784-wfaqim7d 44 11 in in IN cord-256784-wfaqim7d 44 12 humans human NNS cord-256784-wfaqim7d 44 13 , , , cord-256784-wfaqim7d 44 14 RBD RBD NNP cord-256784-wfaqim7d 44 15 or or CC cord-256784-wfaqim7d 44 16 S1-subunit S1-subunit NNPS cord-256784-wfaqim7d 44 17 based base VBN cord-256784-wfaqim7d 44 18 vaccine vaccine NN cord-256784-wfaqim7d 44 19 candidates candidate NNS cord-256784-wfaqim7d 44 20 are be VBP cord-256784-wfaqim7d 44 21 limited limit VBN cord-256784-wfaqim7d 44 22 in in IN cord-256784-wfaqim7d 44 23 their -PRON- PRP$ cord-256784-wfaqim7d 44 24 epitope epitope NN cord-256784-wfaqim7d 44 25 breadth breadth NN cord-256784-wfaqim7d 44 26 . . . cord-256784-wfaqim7d 45 1 Although although IN cord-256784-wfaqim7d 45 2 the the DT cord-256784-wfaqim7d 45 3 coronavirus coronavirus NN cord-256784-wfaqim7d 45 4 genomes genome NNS cord-256784-wfaqim7d 45 5 are be VBP cord-256784-wfaqim7d 45 6 not not RB cord-256784-wfaqim7d 45 7 as as RB cord-256784-wfaqim7d 45 8 variable variable JJ cord-256784-wfaqim7d 45 9 as as IN cord-256784-wfaqim7d 45 10 other other JJ cord-256784-wfaqim7d 45 11 RNA RNA NNP cord-256784-wfaqim7d 45 12 viruses virus NNS cord-256784-wfaqim7d 45 13 , , , cord-256784-wfaqim7d 45 14 the the DT cord-256784-wfaqim7d 45 15 RBD RBD NNP cord-256784-wfaqim7d 45 16 is be VBZ cord-256784-wfaqim7d 45 17 the the DT cord-256784-wfaqim7d 45 18 most most RBS cord-256784-wfaqim7d 45 19 mutable mutable JJ cord-256784-wfaqim7d 45 20 region region NN cord-256784-wfaqim7d 45 21 , , , cord-256784-wfaqim7d 45 22 containing contain VBG cord-256784-wfaqim7d 45 23 mutation mutation NN cord-256784-wfaqim7d 45 24 sites site NNS cord-256784-wfaqim7d 45 25 that that WDT cord-256784-wfaqim7d 45 26 define define VBP cord-256784-wfaqim7d 45 27 antibody antibody NN cord-256784-wfaqim7d 45 28 escape escape NN cord-256784-wfaqim7d 45 29 variants variant NNS cord-256784-wfaqim7d 45 30 [ [ -LRB- cord-256784-wfaqim7d 45 31 25 25 CD cord-256784-wfaqim7d 45 32 , , , cord-256784-wfaqim7d 45 33 32 32 CD cord-256784-wfaqim7d 45 34 ] ] -RRB- cord-256784-wfaqim7d 45 35 . . . cord-256784-wfaqim7d 46 1 Thus thus RB cord-256784-wfaqim7d 46 2 , , , cord-256784-wfaqim7d 46 3 vaccine vaccine NN cord-256784-wfaqim7d 46 4 candidates candidate NNS cord-256784-wfaqim7d 46 5 that that WDT cord-256784-wfaqim7d 46 6 elicit elicit VBP cord-256784-wfaqim7d 46 7 a a DT cord-256784-wfaqim7d 46 8 more more RBR cord-256784-wfaqim7d 46 9 diverse diverse JJ cord-256784-wfaqim7d 46 10 antibody antibody NN cord-256784-wfaqim7d 46 11 repertoire repertoire NN cord-256784-wfaqim7d 46 12 as as RB cord-256784-wfaqim7d 46 13 well well RB cord-256784-wfaqim7d 46 14 as as IN cord-256784-wfaqim7d 46 15 a a DT cord-256784-wfaqim7d 46 16 robust robust JJ cord-256784-wfaqim7d 46 17 cellular cellular JJ cord-256784-wfaqim7d 46 18 immune immune JJ cord-256784-wfaqim7d 46 19 response response NN cord-256784-wfaqim7d 46 20 may may MD cord-256784-wfaqim7d 46 21 offer offer VB cord-256784-wfaqim7d 46 22 the the DT cord-256784-wfaqim7d 46 23 advantage advantage NN cord-256784-wfaqim7d 46 24 of of IN cord-256784-wfaqim7d 46 25 broader broad JJR cord-256784-wfaqim7d 46 26 and and CC cord-256784-wfaqim7d 46 27 more more RBR cord-256784-wfaqim7d 46 28 durable durable JJ cord-256784-wfaqim7d 46 29 protection protection NN cord-256784-wfaqim7d 46 30 . . . cord-256784-wfaqim7d 47 1 Full full JJ cord-256784-wfaqim7d 47 2 - - HYPH cord-256784-wfaqim7d 47 3 length length NN cord-256784-wfaqim7d 47 4 S S NNS cord-256784-wfaqim7d 47 5 used use VBN cord-256784-wfaqim7d 47 6 as as IN cord-256784-wfaqim7d 47 7 an an DT cord-256784-wfaqim7d 47 8 immunogen immunogen NN cord-256784-wfaqim7d 47 9 could could MD cord-256784-wfaqim7d 47 10 at at IN cord-256784-wfaqim7d 47 11 least least JJS cord-256784-wfaqim7d 47 12 increase increase VB cord-256784-wfaqim7d 47 13 the the DT cord-256784-wfaqim7d 47 14 breadth breadth NN cord-256784-wfaqim7d 47 15 of of IN cord-256784-wfaqim7d 47 16 the the DT cord-256784-wfaqim7d 47 17 antibody antibody NN cord-256784-wfaqim7d 47 18 response response NN cord-256784-wfaqim7d 47 19 ; ; : cord-256784-wfaqim7d 47 20 however however RB cord-256784-wfaqim7d 47 21 , , , cord-256784-wfaqim7d 47 22 it -PRON- PRP cord-256784-wfaqim7d 47 23 has have VBZ cord-256784-wfaqim7d 47 24 been be VBN cord-256784-wfaqim7d 47 25 difficult difficult JJ cord-256784-wfaqim7d 47 26 to to TO cord-256784-wfaqim7d 47 27 express express VB cord-256784-wfaqim7d 47 28 , , , cord-256784-wfaqim7d 47 29 and and CC cord-256784-wfaqim7d 47 30 may may MD cord-256784-wfaqim7d 47 31 require require VB cord-256784-wfaqim7d 47 32 additional additional JJ cord-256784-wfaqim7d 47 33 work work NN cord-256784-wfaqim7d 47 34 to to TO cord-256784-wfaqim7d 47 35 produce produce VB cord-256784-wfaqim7d 47 36 a a DT cord-256784-wfaqim7d 47 37 stable stable JJ cord-256784-wfaqim7d 47 38 soluble soluble JJ cord-256784-wfaqim7d 47 39 trimer trimer NN cord-256784-wfaqim7d 47 40 of of IN cord-256784-wfaqim7d 47 41 the the DT cord-256784-wfaqim7d 47 42 S S NNP cord-256784-wfaqim7d 47 43 ectodomain ectodomain NN cord-256784-wfaqim7d 47 44 . . . cord-256784-wfaqim7d 48 1 Investigators investigator NNS cord-256784-wfaqim7d 48 2 at at IN cord-256784-wfaqim7d 48 3 the the DT cord-256784-wfaqim7d 48 4 University University NNP cord-256784-wfaqim7d 48 5 of of IN cord-256784-wfaqim7d 48 6 Maryland Maryland NNP cord-256784-wfaqim7d 48 7 , , , cord-256784-wfaqim7d 48 8 in in IN cord-256784-wfaqim7d 48 9 collaboration collaboration NN cord-256784-wfaqim7d 48 10 with with IN cord-256784-wfaqim7d 48 11 Novavax Novavax NNP cord-256784-wfaqim7d 48 12 , , , cord-256784-wfaqim7d 48 13 Inc. Inc. NNP cord-256784-wfaqim7d 48 14 , , , cord-256784-wfaqim7d 48 15 have have VBP cord-256784-wfaqim7d 48 16 overcome overcome VBN cord-256784-wfaqim7d 48 17 this this DT cord-256784-wfaqim7d 48 18 problem problem NN cord-256784-wfaqim7d 48 19 through through IN cord-256784-wfaqim7d 48 20 the the DT cord-256784-wfaqim7d 48 21 development development NN cord-256784-wfaqim7d 48 22 of of IN cord-256784-wfaqim7d 48 23 S s NN cord-256784-wfaqim7d 48 24 rosettes rosette NNS cord-256784-wfaqim7d 48 25 that that WDT cord-256784-wfaqim7d 48 26 are be VBP cord-256784-wfaqim7d 48 27 stable stable JJ cord-256784-wfaqim7d 48 28 and and CC cord-256784-wfaqim7d 48 29 immunogenic immunogenic JJ cord-256784-wfaqim7d 48 30 in in IN cord-256784-wfaqim7d 48 31 murine murine JJ cord-256784-wfaqim7d 48 32 models model NNS cord-256784-wfaqim7d 48 33 [ [ -LRB- cord-256784-wfaqim7d 48 34 33 33 CD cord-256784-wfaqim7d 48 35 ] ] -RRB- cord-256784-wfaqim7d 48 36 . . . cord-256784-wfaqim7d 49 1 Vaccines vaccine NNS cord-256784-wfaqim7d 49 2 that that WDT cord-256784-wfaqim7d 49 3 mimic mimic VBP cord-256784-wfaqim7d 49 4 natural natural JJ cord-256784-wfaqim7d 49 5 infection infection NN cord-256784-wfaqim7d 49 6 , , , cord-256784-wfaqim7d 49 7 such such JJ cord-256784-wfaqim7d 49 8 as as IN cord-256784-wfaqim7d 49 9 live live RB cord-256784-wfaqim7d 49 10 - - HYPH cord-256784-wfaqim7d 49 11 attenuated attenuate VBN cord-256784-wfaqim7d 49 12 viruses virus NNS cord-256784-wfaqim7d 49 13 or or CC cord-256784-wfaqim7d 49 14 recombinant recombinant JJ cord-256784-wfaqim7d 49 15 viral viral JJ cord-256784-wfaqim7d 49 16 vectors vector NNS cord-256784-wfaqim7d 49 17 , , , cord-256784-wfaqim7d 49 18 may may MD cord-256784-wfaqim7d 49 19 elicit elicit VB cord-256784-wfaqim7d 49 20 even even RB cord-256784-wfaqim7d 49 21 more more RBR cord-256784-wfaqim7d 49 22 robust robust JJ cord-256784-wfaqim7d 49 23 immunity immunity NN cord-256784-wfaqim7d 49 24 . . . cord-256784-wfaqim7d 50 1 Live live VB cord-256784-wfaqim7d 50 2 attenuated attenuated JJ cord-256784-wfaqim7d 50 3 viruses virus NNS cord-256784-wfaqim7d 50 4 have have VBP cord-256784-wfaqim7d 50 5 historically historically RB cord-256784-wfaqim7d 50 6 been be VBN cord-256784-wfaqim7d 50 7 among among IN cord-256784-wfaqim7d 50 8 the the DT cord-256784-wfaqim7d 50 9 most most RBS cord-256784-wfaqim7d 50 10 immunogenic immunogenic JJ cord-256784-wfaqim7d 50 11 platforms platform NNS cord-256784-wfaqim7d 50 12 available available JJ cord-256784-wfaqim7d 50 13 , , , cord-256784-wfaqim7d 50 14 as as IN cord-256784-wfaqim7d 50 15 they -PRON- PRP cord-256784-wfaqim7d 50 16 have have VBP cord-256784-wfaqim7d 50 17 the the DT cord-256784-wfaqim7d 50 18 capacity capacity NN cord-256784-wfaqim7d 50 19 to to TO cord-256784-wfaqim7d 50 20 present present VB cord-256784-wfaqim7d 50 21 multiple multiple JJ cord-256784-wfaqim7d 50 22 antigens antigen NNS cord-256784-wfaqim7d 50 23 across across IN cord-256784-wfaqim7d 50 24 the the DT cord-256784-wfaqim7d 50 25 viral viral JJ cord-256784-wfaqim7d 50 26 life life NN cord-256784-wfaqim7d 50 27 cycle cycle NN cord-256784-wfaqim7d 50 28 in in IN cord-256784-wfaqim7d 50 29 their -PRON- PRP$ cord-256784-wfaqim7d 50 30 native native JJ cord-256784-wfaqim7d 50 31 conformations conformation NNS cord-256784-wfaqim7d 50 32 . . . cord-256784-wfaqim7d 51 1 Although although IN cord-256784-wfaqim7d 51 2 a a DT cord-256784-wfaqim7d 51 3 live live RB cord-256784-wfaqim7d 51 4 - - HYPH cord-256784-wfaqim7d 51 5 attenuated attenuated JJ cord-256784-wfaqim7d 51 6 MERS MERS NNP cord-256784-wfaqim7d 51 7 - - HYPH cord-256784-wfaqim7d 51 8 CoV CoV NNP cord-256784-wfaqim7d 51 9 has have VBZ cord-256784-wfaqim7d 51 10 yet yet RB cord-256784-wfaqim7d 51 11 to to TO cord-256784-wfaqim7d 51 12 be be VB cord-256784-wfaqim7d 51 13 tested test VBN cord-256784-wfaqim7d 51 14 , , , cord-256784-wfaqim7d 51 15 one one PRP cord-256784-wfaqim7d 51 16 has have VBZ cord-256784-wfaqim7d 51 17 been be VBN cord-256784-wfaqim7d 51 18 constructed construct VBN cord-256784-wfaqim7d 51 19 and and CC cord-256784-wfaqim7d 51 20 has have VBZ cord-256784-wfaqim7d 51 21 the the DT cord-256784-wfaqim7d 51 22 potential potential NN cord-256784-wfaqim7d 51 23 to to TO cord-256784-wfaqim7d 51 24 be be VB cord-256784-wfaqim7d 51 25 protective protective JJ cord-256784-wfaqim7d 51 26 [ [ -LRB- cord-256784-wfaqim7d 51 27 34 34 CD cord-256784-wfaqim7d 51 28 ] ] -RRB- cord-256784-wfaqim7d 51 29 . . . cord-256784-wfaqim7d 52 1 However however RB cord-256784-wfaqim7d 52 2 , , , cord-256784-wfaqim7d 52 3 manufacturing manufacture VBG cord-256784-wfaqim7d 52 4 live live RB cord-256784-wfaqim7d 52 5 - - HYPH cord-256784-wfaqim7d 52 6 attenuated attenuate VBN cord-256784-wfaqim7d 52 7 viruses virus NNS cord-256784-wfaqim7d 52 8 requires require VBZ cord-256784-wfaqim7d 52 9 containment containment NN cord-256784-wfaqim7d 52 10 in in IN cord-256784-wfaqim7d 52 11 a a DT cord-256784-wfaqim7d 52 12 biosafety biosafety NN cord-256784-wfaqim7d 52 13 level level NN cord-256784-wfaqim7d 52 14 3 3 CD cord-256784-wfaqim7d 52 15 or or CC cord-256784-wfaqim7d 52 16 4 4 CD cord-256784-wfaqim7d 52 17 facility facility NN cord-256784-wfaqim7d 52 18 . . . cord-256784-wfaqim7d 53 1 Additionally additionally RB cord-256784-wfaqim7d 53 2 , , , cord-256784-wfaqim7d 53 3 live live RB cord-256784-wfaqim7d 53 4 - - HYPH cord-256784-wfaqim7d 53 5 attenuated attenuate VBN cord-256784-wfaqim7d 53 6 viruses virus NNS cord-256784-wfaqim7d 53 7 carry carry VBP cord-256784-wfaqim7d 53 8 the the DT cord-256784-wfaqim7d 53 9 hazards hazard NNS cord-256784-wfaqim7d 53 10 of of IN cord-256784-wfaqim7d 53 11 inadequate inadequate JJ cord-256784-wfaqim7d 53 12 attenuation attenuation NN cord-256784-wfaqim7d 53 13 or or CC cord-256784-wfaqim7d 53 14 reversion reversion NN cord-256784-wfaqim7d 53 15 to to IN cord-256784-wfaqim7d 53 16 wild wild JJ cord-256784-wfaqim7d 53 17 type type NN cord-256784-wfaqim7d 53 18 form form NN cord-256784-wfaqim7d 53 19 and and CC cord-256784-wfaqim7d 53 20 causing cause VBG cord-256784-wfaqim7d 53 21 disseminated disseminate VBN cord-256784-wfaqim7d 53 22 disease disease NN cord-256784-wfaqim7d 53 23 , , , cord-256784-wfaqim7d 53 24 particularly particularly RB cord-256784-wfaqim7d 53 25 in in IN cord-256784-wfaqim7d 53 26 immunocompromised immunocompromised JJ cord-256784-wfaqim7d 53 27 hosts host NNS cord-256784-wfaqim7d 53 28 . . . cord-256784-wfaqim7d 54 1 Given give VBN cord-256784-wfaqim7d 54 2 that that IN cord-256784-wfaqim7d 54 3 moderately moderately RB cord-256784-wfaqim7d 54 4 immunocompromised immunocompromised JJ cord-256784-wfaqim7d 54 5 adults adult NNS cord-256784-wfaqim7d 54 6 with with IN cord-256784-wfaqim7d 54 7 co co NNS cord-256784-wfaqim7d 54 8 - - NNS cord-256784-wfaqim7d 54 9 morbidities morbidity NNS cord-256784-wfaqim7d 54 10 such such JJ cord-256784-wfaqim7d 54 11 as as IN cord-256784-wfaqim7d 54 12 diabetes diabetes NN cord-256784-wfaqim7d 54 13 mellitus mellitus NN cord-256784-wfaqim7d 54 14 and and CC cord-256784-wfaqim7d 54 15 chronic chronic JJ cord-256784-wfaqim7d 54 16 kidney kidney NN cord-256784-wfaqim7d 54 17 disease disease NN cord-256784-wfaqim7d 54 18 have have VBP cord-256784-wfaqim7d 54 19 suffered suffer VBN cord-256784-wfaqim7d 54 20 the the DT cord-256784-wfaqim7d 54 21 most most RBS cord-256784-wfaqim7d 54 22 severe severe JJ cord-256784-wfaqim7d 54 23 MERS MERS NNP cord-256784-wfaqim7d 54 24 - - HYPH cord-256784-wfaqim7d 54 25 CoV cov NN cord-256784-wfaqim7d 54 26 disease disease NN cord-256784-wfaqim7d 54 27 , , , cord-256784-wfaqim7d 54 28 these these DT cord-256784-wfaqim7d 54 29 individuals individual NNS cord-256784-wfaqim7d 54 30 may may MD cord-256784-wfaqim7d 54 31 comprise comprise VB cord-256784-wfaqim7d 54 32 a a DT cord-256784-wfaqim7d 54 33 target target NN cord-256784-wfaqim7d 54 34 population population NN cord-256784-wfaqim7d 54 35 for for IN cord-256784-wfaqim7d 54 36 immunization immunization NN cord-256784-wfaqim7d 54 37 , , , cord-256784-wfaqim7d 54 38 thus thus RB cord-256784-wfaqim7d 54 39 making make VBG cord-256784-wfaqim7d 54 40 a a DT cord-256784-wfaqim7d 54 41 live live RB cord-256784-wfaqim7d 54 42 - - HYPH cord-256784-wfaqim7d 54 43 attenuated attenuated JJ cord-256784-wfaqim7d 54 44 virus virus NN cord-256784-wfaqim7d 54 45 vaccine vaccine NN cord-256784-wfaqim7d 54 46 a a DT cord-256784-wfaqim7d 54 47 less less RBR cord-256784-wfaqim7d 54 48 viable viable JJ cord-256784-wfaqim7d 54 49 option option NN cord-256784-wfaqim7d 54 50 . . . cord-256784-wfaqim7d 55 1 Replication replication NN cord-256784-wfaqim7d 55 2 competent competent JJ cord-256784-wfaqim7d 55 3 viral viral JJ cord-256784-wfaqim7d 55 4 vectors vector NNS cord-256784-wfaqim7d 55 5 could could MD cord-256784-wfaqim7d 55 6 pose pose VB cord-256784-wfaqim7d 55 7 a a DT cord-256784-wfaqim7d 55 8 similar similar JJ cord-256784-wfaqim7d 55 9 threat threat NN cord-256784-wfaqim7d 55 10 for for IN cord-256784-wfaqim7d 55 11 disseminated disseminate VBN cord-256784-wfaqim7d 55 12 disease disease NN cord-256784-wfaqim7d 55 13 in in IN cord-256784-wfaqim7d 55 14 the the DT cord-256784-wfaqim7d 55 15 immunosuppressed immunosuppressed JJ cord-256784-wfaqim7d 55 16 . . . cord-256784-wfaqim7d 56 1 Replication replication NN cord-256784-wfaqim7d 56 2 deficient deficient JJ cord-256784-wfaqim7d 56 3 vectors vector NNS cord-256784-wfaqim7d 56 4 , , , cord-256784-wfaqim7d 56 5 however however RB cord-256784-wfaqim7d 56 6 , , , cord-256784-wfaqim7d 56 7 avoid avoid VB cord-256784-wfaqim7d 56 8 that that DT cord-256784-wfaqim7d 56 9 risk risk NN cord-256784-wfaqim7d 56 10 while while IN cord-256784-wfaqim7d 56 11 maintaining maintain VBG cord-256784-wfaqim7d 56 12 the the DT cord-256784-wfaqim7d 56 13 advantages advantage NNS cord-256784-wfaqim7d 56 14 of of IN cord-256784-wfaqim7d 56 15 native native JJ cord-256784-wfaqim7d 56 16 antigen antigen NN cord-256784-wfaqim7d 56 17 presentation presentation NN cord-256784-wfaqim7d 56 18 , , , cord-256784-wfaqim7d 56 19 elicitation elicitation NN cord-256784-wfaqim7d 56 20 of of IN cord-256784-wfaqim7d 56 21 T T NNP cord-256784-wfaqim7d 56 22 cell cell NN cord-256784-wfaqim7d 56 23 immunity immunity NN cord-256784-wfaqim7d 56 24 and and CC cord-256784-wfaqim7d 56 25 the the DT cord-256784-wfaqim7d 56 26 ability ability NN cord-256784-wfaqim7d 56 27 to to TO cord-256784-wfaqim7d 56 28 express express VB cord-256784-wfaqim7d 56 29 multiple multiple JJ cord-256784-wfaqim7d 56 30 antigens antigen NNS cord-256784-wfaqim7d 56 31 . . . cord-256784-wfaqim7d 57 1 To to IN cord-256784-wfaqim7d 57 2 date date NN cord-256784-wfaqim7d 57 3 , , , cord-256784-wfaqim7d 57 4 two two CD cord-256784-wfaqim7d 57 5 recombinant recombinant JJ cord-256784-wfaqim7d 57 6 vector vector NN cord-256784-wfaqim7d 57 7 platforms platform NNS cord-256784-wfaqim7d 57 8 - - HYPH cord-256784-wfaqim7d 57 9 modified modify VBN cord-256784-wfaqim7d 57 10 Although although IN cord-256784-wfaqim7d 57 11 replication replication NN cord-256784-wfaqim7d 57 12 deficient deficient JJ cord-256784-wfaqim7d 57 13 vectors vector NNS cord-256784-wfaqim7d 57 14 are be VBP cord-256784-wfaqim7d 57 15 relatively relatively RB cord-256784-wfaqim7d 57 16 safe safe JJ cord-256784-wfaqim7d 57 17 and and CC cord-256784-wfaqim7d 57 18 immunogenic immunogenic JJ cord-256784-wfaqim7d 57 19 , , , cord-256784-wfaqim7d 57 20 their -PRON- PRP$ cord-256784-wfaqim7d 57 21 ability ability NN cord-256784-wfaqim7d 57 22 to to TO cord-256784-wfaqim7d 57 23 deliver deliver VB cord-256784-wfaqim7d 57 24 genetic genetic JJ cord-256784-wfaqim7d 57 25 material material NN cord-256784-wfaqim7d 57 26 for for IN cord-256784-wfaqim7d 57 27 expression expression NN cord-256784-wfaqim7d 57 28 could could MD cord-256784-wfaqim7d 57 29 be be VB cord-256784-wfaqim7d 57 30 impeded impede VBN cord-256784-wfaqim7d 57 31 by by IN cord-256784-wfaqim7d 57 32 pre pre JJ cord-256784-wfaqim7d 57 33 - - JJ cord-256784-wfaqim7d 57 34 existing existing JJ cord-256784-wfaqim7d 57 35 or or CC cord-256784-wfaqim7d 57 36 developing develop VBG cord-256784-wfaqim7d 57 37 immunity immunity NN cord-256784-wfaqim7d 57 38 to to IN cord-256784-wfaqim7d 57 39 the the DT cord-256784-wfaqim7d 57 40 vector vector NN cord-256784-wfaqim7d 57 41 itself -PRON- PRP cord-256784-wfaqim7d 57 42 . . . cord-256784-wfaqim7d 58 1 One one CD cord-256784-wfaqim7d 58 2 way way NN cord-256784-wfaqim7d 58 3 to to TO cord-256784-wfaqim7d 58 4 overcome overcome VB cord-256784-wfaqim7d 58 5 this this DT cord-256784-wfaqim7d 58 6 limitation limitation NN cord-256784-wfaqim7d 58 7 is be VBZ cord-256784-wfaqim7d 58 8 by by IN cord-256784-wfaqim7d 58 9 administering administer VBG cord-256784-wfaqim7d 58 10 different different JJ cord-256784-wfaqim7d 58 11 vectors vector NNS cord-256784-wfaqim7d 58 12 in in IN cord-256784-wfaqim7d 58 13 a a DT cord-256784-wfaqim7d 58 14 so so RB cord-256784-wfaqim7d 58 15 - - HYPH cord-256784-wfaqim7d 58 16 called call VBN cord-256784-wfaqim7d 58 17 prime prime JJ cord-256784-wfaqim7d 58 18 - - HYPH cord-256784-wfaqim7d 58 19 boost boost NN cord-256784-wfaqim7d 58 20 immunization immunization NN cord-256784-wfaqim7d 58 21 regimen regimen NN cord-256784-wfaqim7d 58 22 . . . cord-256784-wfaqim7d 59 1 As as IN cord-256784-wfaqim7d 59 2 this this DT cord-256784-wfaqim7d 59 3 strategy strategy NN cord-256784-wfaqim7d 59 4 has have VBZ cord-256784-wfaqim7d 59 5 been be VBN cord-256784-wfaqim7d 59 6 effective effective JJ cord-256784-wfaqim7d 59 7 for for IN cord-256784-wfaqim7d 59 8 other other JJ cord-256784-wfaqim7d 59 9 pathogens pathogen NNS cord-256784-wfaqim7d 59 10 , , , cord-256784-wfaqim7d 59 11 it -PRON- PRP cord-256784-wfaqim7d 59 12 is be VBZ cord-256784-wfaqim7d 59 13 likely likely JJ cord-256784-wfaqim7d 59 14 that that IN cord-256784-wfaqim7d 59 15 the the DT cord-256784-wfaqim7d 59 16 same same JJ cord-256784-wfaqim7d 59 17 success success NN cord-256784-wfaqim7d 59 18 could could MD cord-256784-wfaqim7d 59 19 be be VB cord-256784-wfaqim7d 59 20 recapitulated recapitulate VBN cord-256784-wfaqim7d 59 21 for for IN cord-256784-wfaqim7d 59 22 MERS- MERS- NNP cord-256784-wfaqim7d 60 1 CoV. CoV. NNP cord-256784-wfaqim7d 61 1 The the DT cord-256784-wfaqim7d 61 2 use use NN cord-256784-wfaqim7d 61 3 of of IN cord-256784-wfaqim7d 61 4 more more JJR cord-256784-wfaqim7d 61 5 than than IN cord-256784-wfaqim7d 61 6 one one CD cord-256784-wfaqim7d 61 7 type type NN cord-256784-wfaqim7d 61 8 of of IN cord-256784-wfaqim7d 61 9 platform platform NN cord-256784-wfaqim7d 61 10 or or CC cord-256784-wfaqim7d 61 11 antigen antigen NN cord-256784-wfaqim7d 61 12 in in IN cord-256784-wfaqim7d 61 13 a a DT cord-256784-wfaqim7d 61 14 single single JJ cord-256784-wfaqim7d 61 15 vaccine vaccine NN cord-256784-wfaqim7d 61 16 also also RB cord-256784-wfaqim7d 61 17 increases increase VBZ cord-256784-wfaqim7d 61 18 the the DT cord-256784-wfaqim7d 61 19 likelihood likelihood NN cord-256784-wfaqim7d 61 20 of of IN cord-256784-wfaqim7d 61 21 inducing induce VBG cord-256784-wfaqim7d 61 22 a a DT cord-256784-wfaqim7d 61 23 broad broad JJ cord-256784-wfaqim7d 61 24 repertoire repertoire NN cord-256784-wfaqim7d 61 25 of of IN cord-256784-wfaqim7d 61 26 antibodies antibody NNS cord-256784-wfaqim7d 61 27 with with IN cord-256784-wfaqim7d 61 28 diverse diverse JJ cord-256784-wfaqim7d 61 29 mechanisms mechanism NNS cord-256784-wfaqim7d 61 30 of of IN cord-256784-wfaqim7d 61 31 viral viral JJ cord-256784-wfaqim7d 61 32 neutralization neutralization NN cord-256784-wfaqim7d 61 33 . . . cord-256784-wfaqim7d 62 1 One one CD cord-256784-wfaqim7d 62 2 vaccine vaccine NN cord-256784-wfaqim7d 62 3 regimen regimen NN cord-256784-wfaqim7d 62 4 developed develop VBN cord-256784-wfaqim7d 62 5 at at IN cord-256784-wfaqim7d 62 6 the the DT cord-256784-wfaqim7d 62 7 US US NNP cord-256784-wfaqim7d 62 8 National National NNP cord-256784-wfaqim7d 62 9 Institutes Institutes NNPS cord-256784-wfaqim7d 62 10 of of IN cord-256784-wfaqim7d 62 11 Health Health NNP cord-256784-wfaqim7d 62 12 is be VBZ cord-256784-wfaqim7d 62 13 based base VBN cord-256784-wfaqim7d 62 14 on on IN cord-256784-wfaqim7d 62 15 full full JJ cord-256784-wfaqim7d 62 16 - - HYPH cord-256784-wfaqim7d 62 17 length length NN cord-256784-wfaqim7d 62 18 S S NNP cord-256784-wfaqim7d 62 19 DNA DNA NNP cord-256784-wfaqim7d 62 20 and and CC cord-256784-wfaqim7d 62 21 a a DT cord-256784-wfaqim7d 62 22 truncated truncated JJ cord-256784-wfaqim7d 62 23 S1 s1 NN cord-256784-wfaqim7d 62 24 subunit subunit NN cord-256784-wfaqim7d 62 25 glycoprotein glycoprotein NN cord-256784-wfaqim7d 62 26 and and CC cord-256784-wfaqim7d 62 27 has have VBZ cord-256784-wfaqim7d 62 28 elicited elicit VBN cord-256784-wfaqim7d 62 29 neutralizing neutralize VBG cord-256784-wfaqim7d 62 30 antibodies antibody NNS cord-256784-wfaqim7d 62 31 in in IN cord-256784-wfaqim7d 62 32 mice mouse NNS cord-256784-wfaqim7d 62 33 directed direct VBN cord-256784-wfaqim7d 62 34 at at IN cord-256784-wfaqim7d 62 35 both both CC cord-256784-wfaqim7d 62 36 the the DT cord-256784-wfaqim7d 62 37 S1-within S1-within NNS cord-256784-wfaqim7d 62 38 and and CC cord-256784-wfaqim7d 62 39 outside outside IN cord-256784-wfaqim7d 62 40 the the DT cord-256784-wfaqim7d 62 41 RBD RBD NNP cord-256784-wfaqim7d 62 42 - - HYPH cord-256784-wfaqim7d 62 43 and and CC cord-256784-wfaqim7d 62 44 S2 S2 NNP cord-256784-wfaqim7d 62 45 subunits subunit NNS cord-256784-wfaqim7d 62 46 . . . cord-256784-wfaqim7d 63 1 Immunization immunization NN cord-256784-wfaqim7d 63 2 with with IN cord-256784-wfaqim7d 63 3 these these DT cord-256784-wfaqim7d 63 4 constructs construct NNS cord-256784-wfaqim7d 63 5 also also RB cord-256784-wfaqim7d 63 6 protected protect VBD cord-256784-wfaqim7d 63 7 NHPs nhp NNS cord-256784-wfaqim7d 63 8 from from IN cord-256784-wfaqim7d 63 9 severe severe JJ cord-256784-wfaqim7d 63 10 lung lung NN cord-256784-wfaqim7d 63 11 disease disease NN cord-256784-wfaqim7d 63 12 after after IN cord-256784-wfaqim7d 63 13 intra intra JJ cord-256784-wfaqim7d 63 14 - - JJ cord-256784-wfaqim7d 63 15 tracheal tracheal JJ cord-256784-wfaqim7d 63 16 challenge challenge NN cord-256784-wfaqim7d 63 17 with with IN cord-256784-wfaqim7d 63 18 MERS MERS NNP cord-256784-wfaqim7d 63 19 - - HYPH cord-256784-wfaqim7d 63 20 CoV CoV NNP cord-256784-wfaqim7d 63 21 [ [ -LRB- cord-256784-wfaqim7d 63 22 25 25 CD cord-256784-wfaqim7d 63 23 ] ] -RRB- cord-256784-wfaqim7d 63 24 . . . cord-256784-wfaqim7d 64 1 A a DT cord-256784-wfaqim7d 64 2 DNAonly dnaonly NN cord-256784-wfaqim7d 64 3 vaccine vaccine NN cord-256784-wfaqim7d 64 4 , , , cord-256784-wfaqim7d 64 5 expressing express VBG cord-256784-wfaqim7d 64 6 multiple multiple JJ cord-256784-wfaqim7d 64 7 antigens antigen NNS cord-256784-wfaqim7d 64 8 , , , cord-256784-wfaqim7d 64 9 has have VBZ cord-256784-wfaqim7d 64 10 also also RB cord-256784-wfaqim7d 64 11 been be VBN cord-256784-wfaqim7d 64 12 developed develop VBN cord-256784-wfaqim7d 64 13 by by IN cord-256784-wfaqim7d 64 14 Inovio Inovio NNP cord-256784-wfaqim7d 64 15 Pharmaceuticals Pharmaceuticals NNPS cord-256784-wfaqim7d 64 16 and and CC cord-256784-wfaqim7d 64 17 GeneOne GeneOne NNP cord-256784-wfaqim7d 64 18 Life Life NNP cord-256784-wfaqim7d 64 19 Science Science NNP cord-256784-wfaqim7d 64 20 Inc. Inc. NNP cord-256784-wfaqim7d 64 21 and and CC cord-256784-wfaqim7d 64 22 has have VBZ cord-256784-wfaqim7d 64 23 been be VBN cord-256784-wfaqim7d 64 24 advanced advance VBN cord-256784-wfaqim7d 64 25 to to IN cord-256784-wfaqim7d 64 26 a a DT cord-256784-wfaqim7d 64 27 Phase phase NN cord-256784-wfaqim7d 65 1 I -PRON- PRP cord-256784-wfaqim7d 65 2 first first RB cord-256784-wfaqim7d 65 3 - - HYPH cord-256784-wfaqim7d 65 4 in in IN cord-256784-wfaqim7d 65 5 - - HYPH cord-256784-wfaqim7d 65 6 human human JJ cord-256784-wfaqim7d 65 7 trial trial NN cord-256784-wfaqim7d 65 8 . . . cord-256784-wfaqim7d 66 1 Each each DT cord-256784-wfaqim7d 66 2 of of IN cord-256784-wfaqim7d 66 3 the the DT cord-256784-wfaqim7d 66 4 vaccine vaccine NN cord-256784-wfaqim7d 66 5 candidates candidate NNS cord-256784-wfaqim7d 66 6 that that WDT cord-256784-wfaqim7d 66 7 have have VBP cord-256784-wfaqim7d 66 8 been be VBN cord-256784-wfaqim7d 66 9 mentioned mention VBN cord-256784-wfaqim7d 66 10 is be VBZ cord-256784-wfaqim7d 66 11 being be VBG cord-256784-wfaqim7d 66 12 developed develop VBN cord-256784-wfaqim7d 66 13 for for IN cord-256784-wfaqim7d 66 14 prophylactic prophylactic JJ cord-256784-wfaqim7d 66 15 use use NN cord-256784-wfaqim7d 66 16 . . . cord-256784-wfaqim7d 67 1 However however RB cord-256784-wfaqim7d 67 2 , , , cord-256784-wfaqim7d 67 3 as as IN cord-256784-wfaqim7d 67 4 the the DT cord-256784-wfaqim7d 67 5 total total JJ cord-256784-wfaqim7d 67 6 number number NN cord-256784-wfaqim7d 67 7 of of IN cord-256784-wfaqim7d 67 8 cases case NNS cord-256784-wfaqim7d 67 9 ( ( -LRB- cord-256784-wfaqim7d 67 10 > > NFP cord-256784-wfaqim7d 67 11 1600 1600 CD cord-256784-wfaqim7d 67 12 ) ) -RRB- cord-256784-wfaqim7d 67 13 [ [ -LRB- cord-256784-wfaqim7d 67 14 3 3 CD cord-256784-wfaqim7d 67 15 , , , cord-256784-wfaqim7d 67 16 4 4 CD cord-256784-wfaqim7d 67 17 ] ] -RRB- cord-256784-wfaqim7d 67 18 and and CC cord-256784-wfaqim7d 67 19 reproductive reproductive JJ cord-256784-wfaqim7d 67 20 rate rate NN cord-256784-wfaqim7d 67 21 ( ( -LRB- cord-256784-wfaqim7d 67 22 ∼0.7 ∼0.7 NN cord-256784-wfaqim7d 67 23 ) ) -RRB- cord-256784-wfaqim7d 67 24 of of IN cord-256784-wfaqim7d 67 25 MERS MERS NNP cord-256784-wfaqim7d 67 26 - - HYPH cord-256784-wfaqim7d 67 27 CoV CoV NNP cord-256784-wfaqim7d 67 28 are be VBP cord-256784-wfaqim7d 67 29 both both DT cord-256784-wfaqim7d 67 30 relatively relatively RB cord-256784-wfaqim7d 67 31 low low JJ cord-256784-wfaqim7d 67 32 [ [ -LRB- cord-256784-wfaqim7d 67 33 39 39 CD cord-256784-wfaqim7d 67 34 ] ] -RRB- cord-256784-wfaqim7d 67 35 , , , cord-256784-wfaqim7d 67 36 it -PRON- PRP cord-256784-wfaqim7d 67 37 will will MD cord-256784-wfaqim7d 67 38 be be VB cord-256784-wfaqim7d 67 39 difficult difficult JJ cord-256784-wfaqim7d 67 40 to to TO cord-256784-wfaqim7d 67 41 define define VB cord-256784-wfaqim7d 67 42 the the DT cord-256784-wfaqim7d 67 43 target target NN cord-256784-wfaqim7d 67 44 populations population NNS cord-256784-wfaqim7d 67 45 for for IN cord-256784-wfaqim7d 67 46 vaccination vaccination NN cord-256784-wfaqim7d 67 47 that that WDT cord-256784-wfaqim7d 67 48 would would MD cord-256784-wfaqim7d 67 49 support support VB cord-256784-wfaqim7d 67 50 the the DT cord-256784-wfaqim7d 67 51 investment investment NN cord-256784-wfaqim7d 67 52 in in IN cord-256784-wfaqim7d 67 53 manufacturing manufacturing NN cord-256784-wfaqim7d 67 54 and and CC cord-256784-wfaqim7d 67 55 advanced advanced JJ cord-256784-wfaqim7d 67 56 product product NN cord-256784-wfaqim7d 67 57 development development NN cord-256784-wfaqim7d 67 58 . . . cord-256784-wfaqim7d 68 1 Also also RB cord-256784-wfaqim7d 68 2 , , , cord-256784-wfaqim7d 68 3 with with IN cord-256784-wfaqim7d 68 4 such such JJ cord-256784-wfaqim7d 68 5 low low JJ cord-256784-wfaqim7d 68 6 incidence incidence NN cord-256784-wfaqim7d 68 7 and and CC cord-256784-wfaqim7d 68 8 lack lack NN cord-256784-wfaqim7d 68 9 of of IN cord-256784-wfaqim7d 68 10 robust robust JJ cord-256784-wfaqim7d 68 11 animal animal NN cord-256784-wfaqim7d 68 12 models model NNS cord-256784-wfaqim7d 68 13 , , , cord-256784-wfaqim7d 68 14 it -PRON- PRP cord-256784-wfaqim7d 68 15 would would MD cord-256784-wfaqim7d 68 16 be be VB cord-256784-wfaqim7d 68 17 difficult difficult JJ cord-256784-wfaqim7d 68 18 to to TO cord-256784-wfaqim7d 68 19 achieve achieve VB cord-256784-wfaqim7d 68 20 a a DT cord-256784-wfaqim7d 68 21 vaccine vaccine NN cord-256784-wfaqim7d 68 22 efficacy efficacy NN cord-256784-wfaqim7d 68 23 result result NN cord-256784-wfaqim7d 68 24 that that WDT cord-256784-wfaqim7d 68 25 would would MD cord-256784-wfaqim7d 68 26 be be VB cord-256784-wfaqim7d 68 27 sufficient sufficient JJ cord-256784-wfaqim7d 68 28 to to TO cord-256784-wfaqim7d 68 29 support support VB cord-256784-wfaqim7d 68 30 licensure licensure NN cord-256784-wfaqim7d 68 31 . . . cord-256784-wfaqim7d 69 1 Human Human NNP cord-256784-wfaqim7d 69 2 mAbs mAbs NNP cord-256784-wfaqim7d 69 3 , , , cord-256784-wfaqim7d 69 4 on on IN cord-256784-wfaqim7d 69 5 the the DT cord-256784-wfaqim7d 69 6 other other JJ cord-256784-wfaqim7d 69 7 hand hand NN cord-256784-wfaqim7d 69 8 , , , cord-256784-wfaqim7d 69 9 could could MD cord-256784-wfaqim7d 69 10 be be VB cord-256784-wfaqim7d 69 11 used use VBN cord-256784-wfaqim7d 69 12 without without IN cord-256784-wfaqim7d 69 13 as as RB cord-256784-wfaqim7d 69 14 much much JJ cord-256784-wfaqim7d 69 15 discrimination discrimination NN cord-256784-wfaqim7d 69 16 in in IN cord-256784-wfaqim7d 69 17 an an DT cord-256784-wfaqim7d 69 18 outbreak outbreak NN cord-256784-wfaqim7d 69 19 setting set VBG cord-256784-wfaqim7d 69 20 for for IN cord-256784-wfaqim7d 69 21 post post JJ cord-256784-wfaqim7d 69 22 - - JJ cord-256784-wfaqim7d 69 23 exposure exposure JJ cord-256784-wfaqim7d 69 24 prophylaxis prophylaxis NN cord-256784-wfaqim7d 69 25 and and CC cord-256784-wfaqim7d 69 26 early early JJ cord-256784-wfaqim7d 69 27 treatment treatment NN cord-256784-wfaqim7d 69 28 . . . cord-256784-wfaqim7d 70 1 The the DT cord-256784-wfaqim7d 70 2 advantages advantage NNS cord-256784-wfaqim7d 70 3 of of IN cord-256784-wfaqim7d 70 4 mAbs mAbs NNP cord-256784-wfaqim7d 70 5 over over IN cord-256784-wfaqim7d 70 6 polyclonal polyclonal JJ cord-256784-wfaqim7d 70 7 antibodies antibody NNS cord-256784-wfaqim7d 70 8 ( ( -LRB- cord-256784-wfaqim7d 70 9 administered administer VBN cord-256784-wfaqim7d 70 10 through through IN cord-256784-wfaqim7d 70 11 convalescent convalescent JJ cord-256784-wfaqim7d 70 12 plasma plasma NN cord-256784-wfaqim7d 70 13 or or CC cord-256784-wfaqim7d 70 14 hyperimmune hyperimmune NNP cord-256784-wfaqim7d 70 15 globulin globulin NNP cord-256784-wfaqim7d 70 16 ) ) -RRB- cord-256784-wfaqim7d 70 17 are be VBP cord-256784-wfaqim7d 70 18 their -PRON- PRP$ cord-256784-wfaqim7d 70 19 higher high JJR cord-256784-wfaqim7d 70 20 potency potency NN cord-256784-wfaqim7d 70 21 , , , cord-256784-wfaqim7d 70 22 greater great JJR cord-256784-wfaqim7d 70 23 specificity specificity NN cord-256784-wfaqim7d 70 24 , , , cord-256784-wfaqim7d 70 25 more more RBR cord-256784-wfaqim7d 70 26 extensive extensive JJ cord-256784-wfaqim7d 70 27 pre pre JJ cord-256784-wfaqim7d 70 28 - - JJ cord-256784-wfaqim7d 70 29 licensing licensing JJ cord-256784-wfaqim7d 70 30 evaluation evaluation NN cord-256784-wfaqim7d 70 31 and and CC cord-256784-wfaqim7d 70 32 consequently consequently RB cord-256784-wfaqim7d 70 33 improved improve VBD cord-256784-wfaqim7d 70 34 safety safety NN cord-256784-wfaqim7d 70 35 profile profile NN cord-256784-wfaqim7d 70 36 . . . cord-256784-wfaqim7d 71 1 Additionally additionally RB cord-256784-wfaqim7d 71 2 , , , cord-256784-wfaqim7d 71 3 mAbs mAbs NNP cord-256784-wfaqim7d 71 4 can can MD cord-256784-wfaqim7d 71 5 help help VB cord-256784-wfaqim7d 71 6 define define VB cord-256784-wfaqim7d 71 7 immunogenic immunogenic JJ cord-256784-wfaqim7d 71 8 epitopes epitope NNS cord-256784-wfaqim7d 71 9 through through IN cord-256784-wfaqim7d 71 10 crystallographic crystallographic JJ cord-256784-wfaqim7d 71 11 analysis analysis NN cord-256784-wfaqim7d 71 12 , , , cord-256784-wfaqim7d 71 13 thereby thereby RB cord-256784-wfaqim7d 71 14 providing provide VBG cord-256784-wfaqim7d 71 15 atomic atomic JJ cord-256784-wfaqim7d 71 16 level level NN cord-256784-wfaqim7d 71 17 detail detail NN cord-256784-wfaqim7d 71 18 for for IN cord-256784-wfaqim7d 71 19 the the DT cord-256784-wfaqim7d 71 20 design design NN cord-256784-wfaqim7d 71 21 of of IN cord-256784-wfaqim7d 71 22 better well JJR cord-256784-wfaqim7d 71 23 immunogens immunogen NNS cord-256784-wfaqim7d 71 24 . . . cord-256784-wfaqim7d 72 1 However however RB cord-256784-wfaqim7d 72 2 , , , cord-256784-wfaqim7d 72 3 the the DT cord-256784-wfaqim7d 72 4 timeline timeline NN cord-256784-wfaqim7d 72 5 for for IN cord-256784-wfaqim7d 72 6 mAb mab NN cord-256784-wfaqim7d 72 7 development development NN cord-256784-wfaqim7d 72 8 may may MD cord-256784-wfaqim7d 72 9 be be VB cord-256784-wfaqim7d 72 10 longer long JJR cord-256784-wfaqim7d 72 11 and and CC cord-256784-wfaqim7d 72 12 potentially potentially RB cord-256784-wfaqim7d 72 13 cost cost VBP cord-256784-wfaqim7d 72 14 more more JJR cord-256784-wfaqim7d 72 15 than than IN cord-256784-wfaqim7d 72 16 some some DT cord-256784-wfaqim7d 72 17 vaccines vaccine NNS cord-256784-wfaqim7d 72 18 . . . cord-256784-wfaqim7d 73 1 Despite despite IN cord-256784-wfaqim7d 73 2 requirements requirement NNS cord-256784-wfaqim7d 73 3 for for IN cord-256784-wfaqim7d 73 4 greater great JJR cord-256784-wfaqim7d 73 5 upfront upfront NN cord-256784-wfaqim7d 73 6 investment investment NN cord-256784-wfaqim7d 73 7 , , , cord-256784-wfaqim7d 73 8 several several JJ cord-256784-wfaqim7d 73 9 groups group NNS cord-256784-wfaqim7d 73 10 have have VBP cord-256784-wfaqim7d 73 11 developed develop VBN cord-256784-wfaqim7d 73 12 highly highly RB cord-256784-wfaqim7d 73 13 potent potent JJ cord-256784-wfaqim7d 73 14 mAbs mabs NN cord-256784-wfaqim7d 73 15 that that WDT cord-256784-wfaqim7d 73 16 are be VBP cord-256784-wfaqim7d 73 17 currently currently RB cord-256784-wfaqim7d 73 18 being be VBG cord-256784-wfaqim7d 73 19 advanced advance VBN cord-256784-wfaqim7d 73 20 through through IN cord-256784-wfaqim7d 73 21 pre pre JJ cord-256784-wfaqim7d 73 22 - - JJ cord-256784-wfaqim7d 73 23 clinical clinical JJ cord-256784-wfaqim7d 73 24 stages stage NNS cord-256784-wfaqim7d 73 25 of of IN cord-256784-wfaqim7d 73 26 testing test VBG cord-256784-wfaqim7d 73 27 ( ( -LRB- cord-256784-wfaqim7d 73 28 Fig Fig NNP cord-256784-wfaqim7d 73 29 . . . cord-256784-wfaqim7d 73 30 3 3 CD cord-256784-wfaqim7d 73 31 ) ) -RRB- cord-256784-wfaqim7d 73 32 . . . cord-256784-wfaqim7d 74 1 Some some DT cord-256784-wfaqim7d 74 2 have have VBP cord-256784-wfaqim7d 74 3 been be VBN cord-256784-wfaqim7d 74 4 isolated isolate VBN cord-256784-wfaqim7d 74 5 from from IN cord-256784-wfaqim7d 74 6 immunized immunize VBN cord-256784-wfaqim7d 74 7 animals animal NNS cord-256784-wfaqim7d 74 8 ( ( -LRB- cord-256784-wfaqim7d 74 9 mice mouse NNS cord-256784-wfaqim7d 74 10 / / SYM cord-256784-wfaqim7d 74 11 humanized humanize VBN cord-256784-wfaqim7d 74 12 mice mouse NNS cord-256784-wfaqim7d 74 13 / / SYM cord-256784-wfaqim7d 74 14 NHPs nhp NNS cord-256784-wfaqim7d 74 15 ) ) -RRB- cord-256784-wfaqim7d 74 16 [ [ -LRB- cord-256784-wfaqim7d 74 17 25 25 CD cord-256784-wfaqim7d 74 18 , , , cord-256784-wfaqim7d 74 19 40 40 CD cord-256784-wfaqim7d 74 20 ] ] -RRB- cord-256784-wfaqim7d 74 21 , , , cord-256784-wfaqim7d 74 22 while while IN cord-256784-wfaqim7d 74 23 others other NNS cord-256784-wfaqim7d 74 24 have have VBP cord-256784-wfaqim7d 74 25 been be VBN cord-256784-wfaqim7d 74 26 identified identify VBN cord-256784-wfaqim7d 74 27 from from IN cord-256784-wfaqim7d 74 28 either either CC cord-256784-wfaqim7d 74 29 an an DT cord-256784-wfaqim7d 74 30 antibody antibody NN cord-256784-wfaqim7d 74 31 human human JJ cord-256784-wfaqim7d 74 32 phage phage NN cord-256784-wfaqim7d 74 33 library library NN cord-256784-wfaqim7d 74 34 [ [ -LRB- cord-256784-wfaqim7d 74 35 41 41 CD cord-256784-wfaqim7d 74 36 ] ] -RRB- cord-256784-wfaqim7d 74 37 [ [ -LRB- cord-256784-wfaqim7d 74 38 42 42 CD cord-256784-wfaqim7d 74 39 ] ] -RRB- cord-256784-wfaqim7d 74 40 [ [ -LRB- cord-256784-wfaqim7d 74 41 43 43 CD cord-256784-wfaqim7d 74 42 ] ] -RRB- cord-256784-wfaqim7d 74 43 [ [ -LRB- cord-256784-wfaqim7d 74 44 44 44 CD cord-256784-wfaqim7d 74 45 ] ] -RRB- cord-256784-wfaqim7d 74 46 or or CC cord-256784-wfaqim7d 74 47 memory memory NN cord-256784-wfaqim7d 74 48 B b NN cord-256784-wfaqim7d 74 49 cells cell NNS cord-256784-wfaqim7d 74 50 of of IN cord-256784-wfaqim7d 74 51 infected infected JJ cord-256784-wfaqim7d 74 52 and and CC cord-256784-wfaqim7d 74 53 recovered recover VBN cord-256784-wfaqim7d 74 54 human human JJ cord-256784-wfaqim7d 74 55 survivors survivor NNS cord-256784-wfaqim7d 74 56 [ [ -LRB- cord-256784-wfaqim7d 74 57 45 45 CD cord-256784-wfaqim7d 74 58 ] ] -RRB- cord-256784-wfaqim7d 74 59 . . . cord-256784-wfaqim7d 75 1 Almost almost RB cord-256784-wfaqim7d 75 2 all all DT cord-256784-wfaqim7d 75 3 of of IN cord-256784-wfaqim7d 75 4 the the DT cord-256784-wfaqim7d 75 5 mAbs mabs NN cord-256784-wfaqim7d 75 6 that that WDT cord-256784-wfaqim7d 75 7 have have VBP cord-256784-wfaqim7d 75 8 been be VBN cord-256784-wfaqim7d 75 9 reported report VBN cord-256784-wfaqim7d 75 10 target target VB cord-256784-wfaqim7d 75 11 the the DT cord-256784-wfaqim7d 75 12 Spike Spike NNP cord-256784-wfaqim7d 75 13 RBD RBD NNP cord-256784-wfaqim7d 75 14 . . . cord-256784-wfaqim7d 76 1 It -PRON- PRP cord-256784-wfaqim7d 76 2 is be VBZ cord-256784-wfaqim7d 76 3 likely likely JJ cord-256784-wfaqim7d 76 4 that that IN cord-256784-wfaqim7d 76 5 mAbs mabs NN cord-256784-wfaqim7d 76 6 directed direct VBN cord-256784-wfaqim7d 76 7 at at IN cord-256784-wfaqim7d 76 8 other other JJ cord-256784-wfaqim7d 76 9 sites site NNS cord-256784-wfaqim7d 76 10 on on IN cord-256784-wfaqim7d 76 11 the the DT cord-256784-wfaqim7d 76 12 Spike Spike NNP cord-256784-wfaqim7d 76 13 glycoprotein glycoprotein NN cord-256784-wfaqim7d 76 14 have have VBP cord-256784-wfaqim7d 76 15 been be VBN cord-256784-wfaqim7d 76 16 recovered recover VBN cord-256784-wfaqim7d 76 17 but but CC cord-256784-wfaqim7d 76 18 are be VBP cord-256784-wfaqim7d 76 19 not not RB cord-256784-wfaqim7d 76 20 as as RB cord-256784-wfaqim7d 76 21 potent potent JJ cord-256784-wfaqim7d 76 22 neutralizers neutralizer NNS cord-256784-wfaqim7d 76 23 . . . cord-256784-wfaqim7d 77 1 Most Most JJS cord-256784-wfaqim7d 77 2 of of IN cord-256784-wfaqim7d 77 3 those those DT cord-256784-wfaqim7d 77 4 that that WDT cord-256784-wfaqim7d 77 5 have have VBP cord-256784-wfaqim7d 77 6 been be VBN cord-256784-wfaqim7d 77 7 published publish VBN cord-256784-wfaqim7d 77 8 bind bind NN cord-256784-wfaqim7d 77 9 to to IN cord-256784-wfaqim7d 77 10 recombinant recombinant JJ cord-256784-wfaqim7d 77 11 Spike spike NN cord-256784-wfaqim7d 77 12 with with IN cord-256784-wfaqim7d 77 13 picomolar picomolar JJ cord-256784-wfaqim7d 77 14 affinity affinity NN cord-256784-wfaqim7d 77 15 and and CC cord-256784-wfaqim7d 77 16 neutralize neutralize VB cord-256784-wfaqim7d 77 17 MERS MERS NNP cord-256784-wfaqim7d 77 18 - - HYPH cord-256784-wfaqim7d 77 19 CoV CoV NNP cord-256784-wfaqim7d 77 20 pseudovirus pseudovirus NNP cord-256784-wfaqim7d 77 21 at at IN cord-256784-wfaqim7d 77 22 a a DT cord-256784-wfaqim7d 77 23 half half NN cord-256784-wfaqim7d 77 24 maximal maximal JJ cord-256784-wfaqim7d 77 25 inhibitory inhibitory JJ cord-256784-wfaqim7d 77 26 concentration concentration NN cord-256784-wfaqim7d 77 27 ( ( -LRB- cord-256784-wfaqim7d 77 28 IC IC NNP cord-256784-wfaqim7d 77 29 50 50 CD cord-256784-wfaqim7d 77 30 ) ) -RRB- cord-256784-wfaqim7d 77 31 of of IN cord-256784-wfaqim7d 77 32 0.1 0.1 CD cord-256784-wfaqim7d 77 33 mcg mcg NN cord-256784-wfaqim7d 77 34 / / SYM cord-256784-wfaqim7d 77 35 l l NN cord-256784-wfaqim7d 77 36 or or CC cord-256784-wfaqim7d 77 37 less less JJR cord-256784-wfaqim7d 77 38 . . . cord-256784-wfaqim7d 78 1 Additionally additionally RB cord-256784-wfaqim7d 78 2 , , , cord-256784-wfaqim7d 78 3 some some DT cord-256784-wfaqim7d 78 4 have have VBP cord-256784-wfaqim7d 78 5 demonstrated demonstrate VBN cord-256784-wfaqim7d 78 6 protective protective JJ cord-256784-wfaqim7d 78 7 efficacy efficacy NN cord-256784-wfaqim7d 78 8 in in IN cord-256784-wfaqim7d 78 9 pre pre JJ cord-256784-wfaqim7d 78 10 - - JJ cord-256784-wfaqim7d 78 11 and and CC cord-256784-wfaqim7d 78 12 post post JJ cord-256784-wfaqim7d 78 13 - - JJ cord-256784-wfaqim7d 78 14 exposure exposure JJ cord-256784-wfaqim7d 78 15 prophylaxis prophylaxis NN cord-256784-wfaqim7d 78 16 animal animal NN cord-256784-wfaqim7d 78 17 models model NNS cord-256784-wfaqim7d 78 18 [ [ -LRB- cord-256784-wfaqim7d 78 19 44 44 CD cord-256784-wfaqim7d 78 20 , , , cord-256784-wfaqim7d 78 21 45 45 CD cord-256784-wfaqim7d 78 22 ] ] -RRB- cord-256784-wfaqim7d 78 23 . . . cord-256784-wfaqim7d 79 1 The the DT cord-256784-wfaqim7d 79 2 successes success NNS cord-256784-wfaqim7d 79 3 thus thus RB cord-256784-wfaqim7d 79 4 far far RB cord-256784-wfaqim7d 79 5 in in IN cord-256784-wfaqim7d 79 6 isolating isolate VBG cord-256784-wfaqim7d 79 7 potent potent JJ cord-256784-wfaqim7d 79 8 and and CC cord-256784-wfaqim7d 79 9 protective protective JJ cord-256784-wfaqim7d 79 10 mAbs mAbs NNP cord-256784-wfaqim7d 79 11 may may MD cord-256784-wfaqim7d 79 12 prove prove VB cord-256784-wfaqim7d 79 13 useful useful JJ cord-256784-wfaqim7d 79 14 for for IN cord-256784-wfaqim7d 79 15 therapeutic therapeutic JJ cord-256784-wfaqim7d 79 16 development development NN cord-256784-wfaqim7d 79 17 where where WRB cord-256784-wfaqim7d 79 18 the the DT cord-256784-wfaqim7d 79 19 target target NN cord-256784-wfaqim7d 79 20 population population NN cord-256784-wfaqim7d 79 21 is be VBZ cord-256784-wfaqim7d 79 22 well well RB cord-256784-wfaqim7d 79 23 defined define VBN cord-256784-wfaqim7d 79 24 . . . cord-256784-wfaqim7d 80 1 It -PRON- PRP cord-256784-wfaqim7d 80 2 may may MD cord-256784-wfaqim7d 80 3 prove prove VB cord-256784-wfaqim7d 80 4 more more RBR cord-256784-wfaqim7d 80 5 challenging challenging JJ cord-256784-wfaqim7d 80 6 to to IN cord-256784-wfaqim7d 80 7 advancing advance VBG cord-256784-wfaqim7d 80 8 these these DT cord-256784-wfaqim7d 80 9 products product NNS cord-256784-wfaqim7d 80 10 to to IN cord-256784-wfaqim7d 80 11 licensure licensure NN cord-256784-wfaqim7d 80 12 and and CC cord-256784-wfaqim7d 80 13 fullscale fullscale JJ cord-256784-wfaqim7d 80 14 production production NN cord-256784-wfaqim7d 80 15 at at IN cord-256784-wfaqim7d 80 16 affordable affordable JJ cord-256784-wfaqim7d 80 17 costs cost NNS cord-256784-wfaqim7d 80 18 for for IN cord-256784-wfaqim7d 80 19 the the DT cord-256784-wfaqim7d 80 20 purpose purpose NN cord-256784-wfaqim7d 80 21 of of IN cord-256784-wfaqim7d 80 22 prophylaxis prophylaxis NN cord-256784-wfaqim7d 80 23 in in IN cord-256784-wfaqim7d 80 24 as as IN cord-256784-wfaqim7d 80 25 of of IN cord-256784-wfaqim7d 80 26 yet yet RB cord-256784-wfaqim7d 80 27 undefined undefined JJ cord-256784-wfaqim7d 80 28 populations population NNS cord-256784-wfaqim7d 80 29 . . . cord-256784-wfaqim7d 81 1 The the DT cord-256784-wfaqim7d 81 2 vaguely vaguely RB cord-256784-wfaqim7d 81 3 defined define VBN cord-256784-wfaqim7d 81 4 epidemiology epidemiology NN cord-256784-wfaqim7d 81 5 of of IN cord-256784-wfaqim7d 81 6 MERS MERS NNP cord-256784-wfaqim7d 81 7 - - HYPH cord-256784-wfaqim7d 81 8 CoV CoV NNP cord-256784-wfaqim7d 81 9 has have VBZ cord-256784-wfaqim7d 81 10 complicated complicate VBN cord-256784-wfaqim7d 81 11 the the DT cord-256784-wfaqim7d 81 12 design design NN cord-256784-wfaqim7d 81 13 and and CC cord-256784-wfaqim7d 81 14 implementation implementation NN cord-256784-wfaqim7d 81 15 of of IN cord-256784-wfaqim7d 81 16 appropriate appropriate JJ cord-256784-wfaqim7d 81 17 public public JJ cord-256784-wfaqim7d 81 18 health health NN cord-256784-wfaqim7d 81 19 countermeasures countermeasure NNS cord-256784-wfaqim7d 81 20 . . . cord-256784-wfaqim7d 82 1 Most Most JJS cord-256784-wfaqim7d 82 2 transmission transmission NN cord-256784-wfaqim7d 82 3 events event NNS cord-256784-wfaqim7d 82 4 have have VBP cord-256784-wfaqim7d 82 5 occurred occur VBN cord-256784-wfaqim7d 82 6 either either CC cord-256784-wfaqim7d 82 7 in in IN cord-256784-wfaqim7d 82 8 the the DT cord-256784-wfaqim7d 82 9 setting setting NN cord-256784-wfaqim7d 82 10 of of IN cord-256784-wfaqim7d 82 11 household household NN cord-256784-wfaqim7d 82 12 clusters cluster NNS cord-256784-wfaqim7d 82 13 or or CC cord-256784-wfaqim7d 82 14 nosocomial nosocomial JJ cord-256784-wfaqim7d 82 15 outbreaks outbreak NNS cord-256784-wfaqim7d 82 16 [ [ -LRB- cord-256784-wfaqim7d 82 17 46 46 CD cord-256784-wfaqim7d 82 18 ] ] -RRB- cord-256784-wfaqim7d 83 1 [ [ -LRB- cord-256784-wfaqim7d 83 2 47 47 CD cord-256784-wfaqim7d 83 3 ] ] -RRB- cord-256784-wfaqim7d 84 1 [ [ -LRB- cord-256784-wfaqim7d 84 2 48 48 CD cord-256784-wfaqim7d 84 3 ] ] -RRB- cord-256784-wfaqim7d 85 1 [ [ -LRB- cord-256784-wfaqim7d 85 2 49 49 CD cord-256784-wfaqim7d 85 3 ] ] -RRB- cord-256784-wfaqim7d 85 4 [ [ -LRB- cord-256784-wfaqim7d 85 5 50 50 CD cord-256784-wfaqim7d 85 6 ] ] -RRB- cord-256784-wfaqim7d 85 7 [ [ -LRB- cord-256784-wfaqim7d 85 8 51 51 CD cord-256784-wfaqim7d 85 9 ] ] -RRB- cord-256784-wfaqim7d 85 10 . . . cord-256784-wfaqim7d 86 1 It -PRON- PRP cord-256784-wfaqim7d 86 2 is be VBZ cord-256784-wfaqim7d 86 3 also also RB cord-256784-wfaqim7d 86 4 likely likely JJ cord-256784-wfaqim7d 86 5 that that IN cord-256784-wfaqim7d 86 6 the the DT cord-256784-wfaqim7d 86 7 virus virus NN cord-256784-wfaqim7d 86 8 has have VBZ cord-256784-wfaqim7d 86 9 been be VBN cord-256784-wfaqim7d 86 10 introduced introduce VBN cord-256784-wfaqim7d 86 11 multiple multiple JJ cord-256784-wfaqim7d 86 12 times time NNS cord-256784-wfaqim7d 86 13 into into IN cord-256784-wfaqim7d 86 14 human human JJ cord-256784-wfaqim7d 86 15 populations population NNS cord-256784-wfaqim7d 86 16 from from IN cord-256784-wfaqim7d 86 17 a a DT cord-256784-wfaqim7d 86 18 large large JJ cord-256784-wfaqim7d 86 19 zoonotic zoonotic JJ cord-256784-wfaqim7d 86 20 reservoir reservoir NN cord-256784-wfaqim7d 86 21 , , , cord-256784-wfaqim7d 86 22 i.e. i.e. FW cord-256784-wfaqim7d 86 23 dromedary dromedary NN cord-256784-wfaqim7d 86 24 camels camel NNS cord-256784-wfaqim7d 86 25 . . . cord-256784-wfaqim7d 87 1 Given give VBN cord-256784-wfaqim7d 87 2 the the DT cord-256784-wfaqim7d 87 3 broad broad JJ cord-256784-wfaqim7d 87 4 distribution distribution NN cord-256784-wfaqim7d 87 5 and and CC cord-256784-wfaqim7d 87 6 ownership ownership NN cord-256784-wfaqim7d 87 7 of of IN cord-256784-wfaqim7d 87 8 camels camel NNS cord-256784-wfaqim7d 87 9 in in IN cord-256784-wfaqim7d 87 10 the the DT cord-256784-wfaqim7d 87 11 Arabian Arabian NNP cord-256784-wfaqim7d 87 12 Peninsula Peninsula NNP cord-256784-wfaqim7d 87 13 where where WRB cord-256784-wfaqim7d 87 14 most most JJS cord-256784-wfaqim7d 87 15 cases case NNS cord-256784-wfaqim7d 87 16 have have VBP cord-256784-wfaqim7d 87 17 occurred occur VBN cord-256784-wfaqim7d 87 18 , , , cord-256784-wfaqim7d 87 19 a a DT cord-256784-wfaqim7d 87 20 targeted targeted JJ cord-256784-wfaqim7d 87 21 vaccine vaccine NN cord-256784-wfaqim7d 87 22 campaign campaign NN cord-256784-wfaqim7d 87 23 may may MD cord-256784-wfaqim7d 87 24 prove prove VB cord-256784-wfaqim7d 87 25 difficult difficult JJ cord-256784-wfaqim7d 87 26 . . . cord-256784-wfaqim7d 88 1 As as IN cord-256784-wfaqim7d 88 2 the the DT cord-256784-wfaqim7d 88 3 outbreak outbreak NN cord-256784-wfaqim7d 88 4 in in IN cord-256784-wfaqim7d 88 5 the the DT cord-256784-wfaqim7d 88 6 Republic Republic NNP cord-256784-wfaqim7d 88 7 of of IN cord-256784-wfaqim7d 88 8 Korea Korea NNP cord-256784-wfaqim7d 88 9 revealed reveal VBD cord-256784-wfaqim7d 88 10 , , , cord-256784-wfaqim7d 88 11 patients patient NNS cord-256784-wfaqim7d 88 12 and and CC cord-256784-wfaqim7d 88 13 workers worker NNS cord-256784-wfaqim7d 88 14 in in IN cord-256784-wfaqim7d 88 15 the the DT cord-256784-wfaqim7d 88 16 same same JJ cord-256784-wfaqim7d 88 17 healthcare healthcare NN cord-256784-wfaqim7d 88 18 facility facility NN cord-256784-wfaqim7d 88 19 as as IN cord-256784-wfaqim7d 88 20 an an DT cord-256784-wfaqim7d 88 21 infected infected JJ cord-256784-wfaqim7d 88 22 patient patient NN cord-256784-wfaqim7d 88 23 are be VBP cord-256784-wfaqim7d 88 24 at at IN cord-256784-wfaqim7d 88 25 high high JJ cord-256784-wfaqim7d 88 26 risk risk NN cord-256784-wfaqim7d 88 27 for for IN cord-256784-wfaqim7d 88 28 secondary secondary JJ cord-256784-wfaqim7d 88 29 acquisition acquisition NN cord-256784-wfaqim7d 88 30 . . . cord-256784-wfaqim7d 89 1 An an DT cord-256784-wfaqim7d 89 2 optimal optimal JJ cord-256784-wfaqim7d 89 3 strategy strategy NN cord-256784-wfaqim7d 89 4 may may MD cord-256784-wfaqim7d 89 5 be be VB cord-256784-wfaqim7d 89 6 to to TO cord-256784-wfaqim7d 89 7 use use VB cord-256784-wfaqim7d 89 8 vaccines vaccine NNS cord-256784-wfaqim7d 89 9 in in IN cord-256784-wfaqim7d 89 10 conjunction conjunction NN cord-256784-wfaqim7d 89 11 with with IN cord-256784-wfaqim7d 89 12 stringent stringent JJ cord-256784-wfaqim7d 89 13 infection infection NN cord-256784-wfaqim7d 89 14 control control NN cord-256784-wfaqim7d 89 15 practices practice NNS cord-256784-wfaqim7d 89 16 in in IN cord-256784-wfaqim7d 89 17 hospitals hospital NNS cord-256784-wfaqim7d 89 18 where where WRB cord-256784-wfaqim7d 89 19 MERS MERS NNP cord-256784-wfaqim7d 89 20 - - HYPH cord-256784-wfaqim7d 89 21 CoV cov NN cord-256784-wfaqim7d 89 22 cases case NNS cord-256784-wfaqim7d 89 23 are be VBP cord-256784-wfaqim7d 89 24 being be VBG cord-256784-wfaqim7d 89 25 treated treat VBN cord-256784-wfaqim7d 89 26 . . . cord-256784-wfaqim7d 90 1 The the DT cord-256784-wfaqim7d 90 2 epidemiologic epidemiologic JJ cord-256784-wfaqim7d 90 3 link link NN cord-256784-wfaqim7d 90 4 of of IN cord-256784-wfaqim7d 90 5 MERS MERS NNP cord-256784-wfaqim7d 90 6 - - HYPH cord-256784-wfaqim7d 90 7 CoV CoV NNP cord-256784-wfaqim7d 90 8 between between IN cord-256784-wfaqim7d 90 9 bats bat NNS cord-256784-wfaqim7d 90 10 , , , cord-256784-wfaqim7d 90 11 camels camel NNS cord-256784-wfaqim7d 90 12 , , , cord-256784-wfaqim7d 90 13 and and CC cord-256784-wfaqim7d 90 14 humans human NNS cord-256784-wfaqim7d 90 15 presents present VBZ cord-256784-wfaqim7d 90 16 an an DT cord-256784-wfaqim7d 90 17 opportunity opportunity NN cord-256784-wfaqim7d 90 18 for for IN cord-256784-wfaqim7d 90 19 a a DT cord-256784-wfaqim7d 90 20 veterinary veterinary JJ cord-256784-wfaqim7d 90 21 vaccine vaccine NN cord-256784-wfaqim7d 90 22 to to TO cord-256784-wfaqim7d 90 23 interrupt interrupt VB cord-256784-wfaqim7d 90 24 the the DT cord-256784-wfaqim7d 90 25 transmission transmission NN cord-256784-wfaqim7d 90 26 cycle cycle NN cord-256784-wfaqim7d 90 27 . . . cord-256784-wfaqim7d 91 1 A a DT cord-256784-wfaqim7d 91 2 successful successful JJ cord-256784-wfaqim7d 91 3 precedent precedent NN cord-256784-wfaqim7d 91 4 for for IN cord-256784-wfaqim7d 91 5 this this DT cord-256784-wfaqim7d 91 6 so so RB cord-256784-wfaqim7d 91 7 - - HYPH cord-256784-wfaqim7d 91 8 called call VBN cord-256784-wfaqim7d 91 9 " " `` cord-256784-wfaqim7d 91 10 OneHealth OneHealth NNP cord-256784-wfaqim7d 91 11 " " '' cord-256784-wfaqim7d 91 12 approach approach NN cord-256784-wfaqim7d 91 13 toward toward IN cord-256784-wfaqim7d 91 14 mitigating mitigate VBG cord-256784-wfaqim7d 91 15 human human JJ cord-256784-wfaqim7d 91 16 disease disease NN cord-256784-wfaqim7d 91 17 with with IN cord-256784-wfaqim7d 91 18 a a DT cord-256784-wfaqim7d 91 19 veterinary veterinary JJ cord-256784-wfaqim7d 91 20 vaccine vaccine NN cord-256784-wfaqim7d 91 21 exists exist VBZ cord-256784-wfaqim7d 91 22 in in IN cord-256784-wfaqim7d 91 23 the the DT cord-256784-wfaqim7d 91 24 example example NN cord-256784-wfaqim7d 91 25 of of IN cord-256784-wfaqim7d 91 26 Equivac Equivac NNP cord-256784-wfaqim7d 91 27 ® ® NNP cord-256784-wfaqim7d 91 28 , , , cord-256784-wfaqim7d 91 29 a a DT cord-256784-wfaqim7d 91 30 Hendra Hendra NNP cord-256784-wfaqim7d 91 31 virus virus NN cord-256784-wfaqim7d 91 32 vaccine vaccine NN cord-256784-wfaqim7d 91 33 developed develop VBD cord-256784-wfaqim7d 91 34 solely solely RB cord-256784-wfaqim7d 91 35 for for IN cord-256784-wfaqim7d 91 36 horses horse NNS cord-256784-wfaqim7d 91 37 [ [ -LRB- cord-256784-wfaqim7d 91 38 52 52 CD cord-256784-wfaqim7d 91 39 ] ] -RRB- cord-256784-wfaqim7d 91 40 . . . cord-256784-wfaqim7d 92 1 Although although IN cord-256784-wfaqim7d 92 2 Hendra Hendra NNP cord-256784-wfaqim7d 92 3 virus virus NN cord-256784-wfaqim7d 92 4 is be VBZ cord-256784-wfaqim7d 92 5 even even RB cord-256784-wfaqim7d 92 6 more more RBR cord-256784-wfaqim7d 92 7 rare rare JJ cord-256784-wfaqim7d 92 8 than than IN cord-256784-wfaqim7d 92 9 MERS MERS NNP cord-256784-wfaqim7d 92 10 - - HYPH cord-256784-wfaqim7d 92 11 CoV CoV NNP cord-256784-wfaqim7d 92 12 , , , cord-256784-wfaqim7d 92 13 it -PRON- PRP cord-256784-wfaqim7d 92 14 is be VBZ cord-256784-wfaqim7d 92 15 highly highly RB cord-256784-wfaqim7d 92 16 fatal fatal JJ cord-256784-wfaqim7d 92 17 with with IN cord-256784-wfaqim7d 92 18 no no DT cord-256784-wfaqim7d 92 19 treatment treatment NN cord-256784-wfaqim7d 92 20 other other JJ cord-256784-wfaqim7d 92 21 than than IN cord-256784-wfaqim7d 92 22 intensive intensive JJ cord-256784-wfaqim7d 92 23 supportive supportive JJ cord-256784-wfaqim7d 92 24 management management NN cord-256784-wfaqim7d 92 25 . . . cord-256784-wfaqim7d 93 1 In in IN cord-256784-wfaqim7d 93 2 2012 2012 CD cord-256784-wfaqim7d 93 3 , , , cord-256784-wfaqim7d 93 4 a a DT cord-256784-wfaqim7d 93 5 protein protein NN cord-256784-wfaqim7d 93 6 subunit subunit NN cord-256784-wfaqim7d 93 7 vaccine vaccine NN cord-256784-wfaqim7d 93 8 was be VBD cord-256784-wfaqim7d 93 9 licensed license VBN cord-256784-wfaqim7d 93 10 and and CC cord-256784-wfaqim7d 93 11 rolled roll VBN cord-256784-wfaqim7d 93 12 - - HYPH cord-256784-wfaqim7d 93 13 out out NN cord-256784-wfaqim7d 93 14 in in IN cord-256784-wfaqim7d 93 15 Australia Australia NNP cord-256784-wfaqim7d 93 16 , , , cord-256784-wfaqim7d 93 17 where where WRB cord-256784-wfaqim7d 93 18 all all DT cord-256784-wfaqim7d 93 19 outbreaks outbreak NNS cord-256784-wfaqim7d 93 20 of of IN cord-256784-wfaqim7d 93 21 the the DT cord-256784-wfaqim7d 93 22 virus virus NN cord-256784-wfaqim7d 93 23 occurred occur VBD cord-256784-wfaqim7d 93 24 . . . cord-256784-wfaqim7d 94 1 Since since IN cord-256784-wfaqim7d 94 2 that that DT cord-256784-wfaqim7d 94 3 time time NN cord-256784-wfaqim7d 94 4 , , , cord-256784-wfaqim7d 94 5 the the DT cord-256784-wfaqim7d 94 6 incidence incidence NN cord-256784-wfaqim7d 94 7 in in IN cord-256784-wfaqim7d 94 8 horses horse NNS cord-256784-wfaqim7d 94 9 has have VBZ cord-256784-wfaqim7d 94 10 fallen fall VBN cord-256784-wfaqim7d 94 11 precipitously precipitously RB cord-256784-wfaqim7d 94 12 and and CC cord-256784-wfaqim7d 94 13 no no DT cord-256784-wfaqim7d 94 14 human human JJ cord-256784-wfaqim7d 94 15 cases case NNS cord-256784-wfaqim7d 94 16 have have VBP cord-256784-wfaqim7d 94 17 been be VBN cord-256784-wfaqim7d 94 18 detected detect VBN cord-256784-wfaqim7d 94 19 [ [ -LRB- cord-256784-wfaqim7d 94 20 53 53 CD cord-256784-wfaqim7d 94 21 ] ] -RRB- cord-256784-wfaqim7d 94 22 . . . cord-256784-wfaqim7d 95 1 A a DT cord-256784-wfaqim7d 95 2 similar similar JJ cord-256784-wfaqim7d 95 3 strategy strategy NN cord-256784-wfaqim7d 95 4 may may MD cord-256784-wfaqim7d 95 5 be be VB cord-256784-wfaqim7d 95 6 applicable applicable JJ cord-256784-wfaqim7d 95 7 to to IN cord-256784-wfaqim7d 95 8 MERS MERS NNP cord-256784-wfaqim7d 95 9 - - HYPH cord-256784-wfaqim7d 95 10 CoV CoV NNP cord-256784-wfaqim7d 95 11 ; ; : cord-256784-wfaqim7d 95 12 however however RB cord-256784-wfaqim7d 95 13 , , , cord-256784-wfaqim7d 95 14 a a DT cord-256784-wfaqim7d 95 15 veterinary veterinary JJ cord-256784-wfaqim7d 95 16 vaccination vaccination NN cord-256784-wfaqim7d 95 17 in in IN cord-256784-wfaqim7d 95 18 this this DT cord-256784-wfaqim7d 95 19 context context NN cord-256784-wfaqim7d 95 20 would would MD cord-256784-wfaqim7d 95 21 be be VB cord-256784-wfaqim7d 95 22 deployed deploy VBN cord-256784-wfaqim7d 95 23 solely solely RB cord-256784-wfaqim7d 95 24 for for IN cord-256784-wfaqim7d 95 25 the the DT cord-256784-wfaqim7d 95 26 sake sake NN cord-256784-wfaqim7d 95 27 of of IN cord-256784-wfaqim7d 95 28 protecting protect VBG cord-256784-wfaqim7d 95 29 humans human NNS cord-256784-wfaqim7d 95 30 , , , cord-256784-wfaqim7d 95 31 as as IN cord-256784-wfaqim7d 95 32 the the DT cord-256784-wfaqim7d 95 33 virus virus NN cord-256784-wfaqim7d 95 34 causes cause VBZ cord-256784-wfaqim7d 95 35 only only RB cord-256784-wfaqim7d 95 36 mild mild JJ cord-256784-wfaqim7d 95 37 upper upper JJ cord-256784-wfaqim7d 95 38 respiratory respiratory JJ cord-256784-wfaqim7d 95 39 illness illness NN cord-256784-wfaqim7d 95 40 in in IN cord-256784-wfaqim7d 95 41 camels camel NNS cord-256784-wfaqim7d 95 42 . . . cord-256784-wfaqim7d 96 1 Safety safety NN cord-256784-wfaqim7d 96 2 and and CC cord-256784-wfaqim7d 96 3 reduction reduction NN cord-256784-wfaqim7d 96 4 in in IN cord-256784-wfaqim7d 96 5 viral viral JJ cord-256784-wfaqim7d 96 6 shedding shedding NN cord-256784-wfaqim7d 96 7 would would MD cord-256784-wfaqim7d 96 8 have have VB cord-256784-wfaqim7d 96 9 to to TO cord-256784-wfaqim7d 96 10 be be VB cord-256784-wfaqim7d 96 11 demonstrated demonstrate VBN cord-256784-wfaqim7d 96 12 in in IN cord-256784-wfaqim7d 96 13 immunization immunization NN cord-256784-wfaqim7d 96 14 , , , cord-256784-wfaqim7d 96 15 challenge challenge NN cord-256784-wfaqim7d 96 16 and and CC cord-256784-wfaqim7d 96 17 transmission transmission NN cord-256784-wfaqim7d 96 18 studies study NNS cord-256784-wfaqim7d 96 19 of of IN cord-256784-wfaqim7d 96 20 camel camel NN cord-256784-wfaqim7d 96 21 or or CC cord-256784-wfaqim7d 96 22 camelid camelid NNP cord-256784-wfaqim7d 96 23 populations population NNS cord-256784-wfaqim7d 96 24 , , . cord-256784-wfaqim7d 97 1 one one CD cord-256784-wfaqim7d 97 2 of of IN cord-256784-wfaqim7d 97 3 which which WDT cord-256784-wfaqim7d 97 4 has have VBZ cord-256784-wfaqim7d 97 5 shown show VBN cord-256784-wfaqim7d 97 6 efficacy efficacy NN cord-256784-wfaqim7d 97 7 [ [ -LRB- cord-256784-wfaqim7d 97 8 54 54 CD cord-256784-wfaqim7d 97 9 ] ] -RRB- cord-256784-wfaqim7d 97 10 . . . cord-256784-wfaqim7d 98 1 One one CD cord-256784-wfaqim7d 98 2 of of IN cord-256784-wfaqim7d 98 3 the the DT cord-256784-wfaqim7d 98 4 primary primary JJ cord-256784-wfaqim7d 98 5 challenges challenge NNS cord-256784-wfaqim7d 98 6 to to IN cord-256784-wfaqim7d 98 7 developing develop VBG cord-256784-wfaqim7d 98 8 countermeasures countermeasure NNS cord-256784-wfaqim7d 98 9 to to IN cord-256784-wfaqim7d 98 10 MERS MERS NNP cord-256784-wfaqim7d 98 11 - - HYPH cord-256784-wfaqim7d 98 12 CoV CoV NNP cord-256784-wfaqim7d 98 13 is be VBZ cord-256784-wfaqim7d 98 14 the the DT cord-256784-wfaqim7d 98 15 lack lack NN cord-256784-wfaqim7d 98 16 of of IN cord-256784-wfaqim7d 98 17 an an DT cord-256784-wfaqim7d 98 18 appropriate appropriate JJ cord-256784-wfaqim7d 98 19 animal animal NN cord-256784-wfaqim7d 98 20 model model NN cord-256784-wfaqim7d 98 21 that that WDT cord-256784-wfaqim7d 98 22 recapitulates recapitulate VBZ cord-256784-wfaqim7d 98 23 the the DT cord-256784-wfaqim7d 98 24 natural natural JJ cord-256784-wfaqim7d 98 25 history history NN cord-256784-wfaqim7d 98 26 of of IN cord-256784-wfaqim7d 98 27 human human JJ cord-256784-wfaqim7d 98 28 disease disease NN cord-256784-wfaqim7d 98 29 . . . cord-256784-wfaqim7d 99 1 Much much JJ cord-256784-wfaqim7d 99 2 of of IN cord-256784-wfaqim7d 99 3 the the DT cord-256784-wfaqim7d 99 4 difficulty difficulty NN cord-256784-wfaqim7d 99 5 originates originate VBZ cord-256784-wfaqim7d 99 6 from from IN cord-256784-wfaqim7d 99 7 the the DT cord-256784-wfaqim7d 99 8 absence absence NN cord-256784-wfaqim7d 99 9 of of IN cord-256784-wfaqim7d 99 10 the the DT cord-256784-wfaqim7d 99 11 virus virus NN cord-256784-wfaqim7d 99 12 's 's POS cord-256784-wfaqim7d 99 13 cognate cognate JJ cord-256784-wfaqim7d 99 14 DPP4 DPP4 NNP cord-256784-wfaqim7d 99 15 receptor receptor NN cord-256784-wfaqim7d 99 16 . . . cord-256784-wfaqim7d 100 1 One one CD cord-256784-wfaqim7d 100 2 group group NN cord-256784-wfaqim7d 100 3 approached approach VBD cord-256784-wfaqim7d 100 4 this this DT cord-256784-wfaqim7d 100 5 problem problem NN cord-256784-wfaqim7d 100 6 by by IN cord-256784-wfaqim7d 100 7 successfully successfully RB cord-256784-wfaqim7d 100 8 transducing transduce VBG cord-256784-wfaqim7d 100 9 mice mouse NNS cord-256784-wfaqim7d 100 10 with with IN cord-256784-wfaqim7d 100 11 an an DT cord-256784-wfaqim7d 100 12 adenoviral adenoviral JJ cord-256784-wfaqim7d 100 13 vector vector NN cord-256784-wfaqim7d 100 14 expressing express VBG cord-256784-wfaqim7d 100 15 human human JJ cord-256784-wfaqim7d 100 16 DPP4 DPP4 NNP cord-256784-wfaqim7d 100 17 [ [ -LRB- cord-256784-wfaqim7d 100 18 55 55 CD cord-256784-wfaqim7d 100 19 ] ] -RRB- cord-256784-wfaqim7d 100 20 . . . cord-256784-wfaqim7d 101 1 Although although IN cord-256784-wfaqim7d 101 2 more more RBR cord-256784-wfaqim7d 101 3 relevant relevant JJ cord-256784-wfaqim7d 101 4 than than IN cord-256784-wfaqim7d 101 5 a a DT cord-256784-wfaqim7d 101 6 standard standard JJ cord-256784-wfaqim7d 101 7 murine murine JJ cord-256784-wfaqim7d 101 8 model model NN cord-256784-wfaqim7d 101 9 , , , cord-256784-wfaqim7d 101 10 transient transient JJ cord-256784-wfaqim7d 101 11 transduction transduction NN cord-256784-wfaqim7d 101 12 of of IN cord-256784-wfaqim7d 101 13 the the DT cord-256784-wfaqim7d 101 14 desired desire VBN cord-256784-wfaqim7d 101 15 protein protein NN cord-256784-wfaqim7d 101 16 may may MD cord-256784-wfaqim7d 101 17 result result VB cord-256784-wfaqim7d 101 18 in in IN cord-256784-wfaqim7d 101 19 inconsistent inconsistent JJ cord-256784-wfaqim7d 101 20 tissue tissue NN cord-256784-wfaqim7d 101 21 expression expression NN cord-256784-wfaqim7d 101 22 of of IN cord-256784-wfaqim7d 101 23 adenovirus adenovirus NN cord-256784-wfaqim7d 101 24 antigens antigen NNS cord-256784-wfaqim7d 101 25 . . . cord-256784-wfaqim7d 102 1 Agrawal Agrawal NNP cord-256784-wfaqim7d 102 2 et et NNP cord-256784-wfaqim7d 102 3 al al NNP cord-256784-wfaqim7d 102 4 . . NNP cord-256784-wfaqim7d 102 5 made make VBD cord-256784-wfaqim7d 102 6 an an DT cord-256784-wfaqim7d 102 7 important important JJ cord-256784-wfaqim7d 102 8 advance advance NN cord-256784-wfaqim7d 102 9 with with IN cord-256784-wfaqim7d 102 10 the the DT cord-256784-wfaqim7d 102 11 development development NN cord-256784-wfaqim7d 102 12 of of IN cord-256784-wfaqim7d 102 13 a a DT cord-256784-wfaqim7d 102 14 transgenic transgenic JJ cord-256784-wfaqim7d 102 15 mouse mouse NN cord-256784-wfaqim7d 102 16 model model NN cord-256784-wfaqim7d 102 17 that that WDT cord-256784-wfaqim7d 102 18 demonstrated demonstrate VBD cord-256784-wfaqim7d 102 19 productive productive JJ cord-256784-wfaqim7d 102 20 , , , cord-256784-wfaqim7d 102 21 disseminated disseminate VBN cord-256784-wfaqim7d 102 22 MERS MERS NNP cord-256784-wfaqim7d 102 23 - - HYPH cord-256784-wfaqim7d 102 24 CoV cov NN cord-256784-wfaqim7d 102 25 infection infection NN cord-256784-wfaqim7d 102 26 [ [ -LRB- cord-256784-wfaqim7d 102 27 56 56 CD cord-256784-wfaqim7d 102 28 ] ] -RRB- cord-256784-wfaqim7d 102 29 . . . cord-256784-wfaqim7d 103 1 Although although IN cord-256784-wfaqim7d 103 2 rhesus rhesu NNS cord-256784-wfaqim7d 103 3 macaques macaque NNS cord-256784-wfaqim7d 103 4 do do VBP cord-256784-wfaqim7d 103 5 not not RB cord-256784-wfaqim7d 103 6 manifest manifest VB cord-256784-wfaqim7d 103 7 full full JJ cord-256784-wfaqim7d 103 8 clinical clinical JJ cord-256784-wfaqim7d 103 9 disease disease NN cord-256784-wfaqim7d 103 10 , , , cord-256784-wfaqim7d 103 11 they -PRON- PRP cord-256784-wfaqim7d 103 12 develop develop VBP cord-256784-wfaqim7d 103 13 a a DT cord-256784-wfaqim7d 103 14 transient transient JJ cord-256784-wfaqim7d 103 15 lower low JJR cord-256784-wfaqim7d 103 16 respiratory respiratory JJ cord-256784-wfaqim7d 103 17 infection infection NN cord-256784-wfaqim7d 103 18 that that WDT cord-256784-wfaqim7d 103 19 can can MD cord-256784-wfaqim7d 103 20 be be VB cord-256784-wfaqim7d 103 21 quantified quantify VBN cord-256784-wfaqim7d 103 22 and and CC cord-256784-wfaqim7d 103 23 evaluated evaluate VBN cord-256784-wfaqim7d 103 24 by by IN cord-256784-wfaqim7d 103 25 computed compute VBN cord-256784-wfaqim7d 103 26 tomography tomography NN cord-256784-wfaqim7d 103 27 . . . cord-256784-wfaqim7d 104 1 Investigators investigator NNS cord-256784-wfaqim7d 104 2 at at IN cord-256784-wfaqim7d 104 3 the the DT cord-256784-wfaqim7d 104 4 NIH NIH NNP cord-256784-wfaqim7d 104 5 Rocky Rocky NNP cord-256784-wfaqim7d 104 6 Mountain Mountain NNP cord-256784-wfaqim7d 104 7 Laboratories Laboratories NNP cord-256784-wfaqim7d 104 8 ( ( -LRB- cord-256784-wfaqim7d 104 9 RML RML NNP cord-256784-wfaqim7d 104 10 ) ) -RRB- cord-256784-wfaqim7d 104 11 and and CC cord-256784-wfaqim7d 104 12 Integrated Integrated NNP cord-256784-wfaqim7d 104 13 Research Research NNP cord-256784-wfaqim7d 104 14 Facility Facility NNP cord-256784-wfaqim7d 104 15 ( ( -LRB- cord-256784-wfaqim7d 104 16 IRF IRF NNP cord-256784-wfaqim7d 104 17 ) ) -RRB- cord-256784-wfaqim7d 104 18 have have VBP cord-256784-wfaqim7d 104 19 also also RB cord-256784-wfaqim7d 104 20 independently independently RB cord-256784-wfaqim7d 104 21 been be VBN cord-256784-wfaqim7d 104 22 developing develop VBG cord-256784-wfaqim7d 104 23 potentially potentially RB cord-256784-wfaqim7d 104 24 lethal lethal JJ cord-256784-wfaqim7d 104 25 marmoset marmoset NN cord-256784-wfaqim7d 104 26 models model NNS cord-256784-wfaqim7d 104 27 that that WDT cord-256784-wfaqim7d 104 28 could could MD cord-256784-wfaqim7d 104 29 be be VB cord-256784-wfaqim7d 104 30 used use VBN cord-256784-wfaqim7d 104 31 for for IN cord-256784-wfaqim7d 104 32 the the DT cord-256784-wfaqim7d 104 33 evaluation evaluation NN cord-256784-wfaqim7d 104 34 of of IN cord-256784-wfaqim7d 104 35 vaccines vaccine NNS cord-256784-wfaqim7d 104 36 , , , cord-256784-wfaqim7d 104 37 mAbs mAbs NNP cord-256784-wfaqim7d 104 38 and and CC cord-256784-wfaqim7d 104 39 therapeutics therapeutic NNS cord-256784-wfaqim7d 104 40 [ [ -LRB- cord-256784-wfaqim7d 104 41 57 57 CD cord-256784-wfaqim7d 104 42 ] ] -RRB- cord-256784-wfaqim7d 104 43 . . . cord-256784-wfaqim7d 105 1 As as IN cord-256784-wfaqim7d 105 2 MERS MERS NNP cord-256784-wfaqim7d 105 3 - - HYPH cord-256784-wfaqim7d 105 4 CoV CoV NNP cord-256784-wfaqim7d 105 5 vaccines vaccine NNS cord-256784-wfaqim7d 105 6 - - : cord-256784-wfaqim7d 105 7 both both CC cord-256784-wfaqim7d 105 8 active active JJ cord-256784-wfaqim7d 105 9 and and CC cord-256784-wfaqim7d 105 10 passive passive JJ cord-256784-wfaqim7d 105 11 - - : cord-256784-wfaqim7d 105 12 are be VBP cord-256784-wfaqim7d 105 13 developed develop VBN cord-256784-wfaqim7d 105 14 and and CC cord-256784-wfaqim7d 105 15 tested test VBN cord-256784-wfaqim7d 105 16 , , , cord-256784-wfaqim7d 105 17 not not RB cord-256784-wfaqim7d 105 18 only only RB cord-256784-wfaqim7d 105 19 will will MD cord-256784-wfaqim7d 105 20 more more RBR cord-256784-wfaqim7d 105 21 relevant relevant JJ cord-256784-wfaqim7d 105 22 animal animal NN cord-256784-wfaqim7d 105 23 models model NNS cord-256784-wfaqim7d 105 24 be be VB cord-256784-wfaqim7d 105 25 required require VBN cord-256784-wfaqim7d 105 26 , , , cord-256784-wfaqim7d 105 27 but but CC cord-256784-wfaqim7d 105 28 there there EX cord-256784-wfaqim7d 105 29 will will MD cord-256784-wfaqim7d 105 30 also also RB cord-256784-wfaqim7d 105 31 be be VB cord-256784-wfaqim7d 105 32 a a DT cord-256784-wfaqim7d 105 33 need need NN cord-256784-wfaqim7d 105 34 for for IN cord-256784-wfaqim7d 105 35 a a DT cord-256784-wfaqim7d 105 36 more more RBR cord-256784-wfaqim7d 105 37 detailed detailed JJ cord-256784-wfaqim7d 105 38 understanding understanding NN cord-256784-wfaqim7d 105 39 of of IN cord-256784-wfaqim7d 105 40 the the DT cord-256784-wfaqim7d 105 41 epidemiology epidemiology NN cord-256784-wfaqim7d 105 42 , , , cord-256784-wfaqim7d 105 43 immunology immunology NN cord-256784-wfaqim7d 105 44 , , , cord-256784-wfaqim7d 105 45 and and CC cord-256784-wfaqim7d 105 46 pathogenesis pathogenesis NN cord-256784-wfaqim7d 105 47 of of IN cord-256784-wfaqim7d 105 48 the the DT cord-256784-wfaqim7d 105 49 virus virus NN cord-256784-wfaqim7d 105 50 . . . cord-256784-wfaqim7d 106 1 In in IN cord-256784-wfaqim7d 106 2 the the DT cord-256784-wfaqim7d 106 3 aftermath aftermath NN cord-256784-wfaqim7d 106 4 of of IN cord-256784-wfaqim7d 106 5 the the DT cord-256784-wfaqim7d 106 6 West west JJ cord-256784-wfaqim7d 106 7 African african JJ cord-256784-wfaqim7d 106 8 Ebola Ebola NNP cord-256784-wfaqim7d 106 9 virus virus NN cord-256784-wfaqim7d 106 10 epidemic epidemic NN cord-256784-wfaqim7d 106 11 and and CC cord-256784-wfaqim7d 106 12 in in IN cord-256784-wfaqim7d 106 13 the the DT cord-256784-wfaqim7d 106 14 face face NN cord-256784-wfaqim7d 106 15 of of IN cord-256784-wfaqim7d 106 16 the the DT cord-256784-wfaqim7d 106 17 current current JJ cord-256784-wfaqim7d 106 18 Zika Zika NNP cord-256784-wfaqim7d 106 19 virus virus NN cord-256784-wfaqim7d 106 20 outbreak outbreak NN cord-256784-wfaqim7d 106 21 , , , cord-256784-wfaqim7d 106 22 the the DT cord-256784-wfaqim7d 106 23 global global JJ cord-256784-wfaqim7d 106 24 health health NN cord-256784-wfaqim7d 106 25 community community NN cord-256784-wfaqim7d 106 26 has have VBZ cord-256784-wfaqim7d 106 27 coalesced coalesce VBN cord-256784-wfaqim7d 106 28 around around IN cord-256784-wfaqim7d 106 29 the the DT cord-256784-wfaqim7d 106 30 realization realization NN cord-256784-wfaqim7d 106 31 that that IN cord-256784-wfaqim7d 106 32 a a DT cord-256784-wfaqim7d 106 33 multi multi JJ cord-256784-wfaqim7d 106 34 - - JJ cord-256784-wfaqim7d 106 35 faceted faceted JJ cord-256784-wfaqim7d 106 36 plan plan NN cord-256784-wfaqim7d 106 37 is be VBZ cord-256784-wfaqim7d 106 38 required require VBN cord-256784-wfaqim7d 106 39 to to TO cord-256784-wfaqim7d 106 40 quickly quickly RB cord-256784-wfaqim7d 106 41 and and CC cord-256784-wfaqim7d 106 42 efficiently efficiently RB cord-256784-wfaqim7d 106 43 respond respond VB cord-256784-wfaqim7d 106 44 to to IN cord-256784-wfaqim7d 106 45 global global JJ cord-256784-wfaqim7d 106 46 public public JJ cord-256784-wfaqim7d 106 47 health health NN cord-256784-wfaqim7d 106 48 emergencies emergency NNS cord-256784-wfaqim7d 106 49 . . . cord-256784-wfaqim7d 107 1 The the DT cord-256784-wfaqim7d 107 2 World World NNP cord-256784-wfaqim7d 107 3 Health Health NNP cord-256784-wfaqim7d 107 4 Organization Organization NNP cord-256784-wfaqim7d 107 5 is be VBZ cord-256784-wfaqim7d 107 6 currently currently RB cord-256784-wfaqim7d 107 7 developing develop VBG cord-256784-wfaqim7d 107 8 a a DT cord-256784-wfaqim7d 107 9 blueprint blueprint NN cord-256784-wfaqim7d 107 10 by by IN cord-256784-wfaqim7d 107 11 which which WDT cord-256784-wfaqim7d 107 12 that that IN cord-256784-wfaqim7d 107 13 preparation preparation NN cord-256784-wfaqim7d 107 14 and and CC cord-256784-wfaqim7d 107 15 response response NN cord-256784-wfaqim7d 107 16 can can MD cord-256784-wfaqim7d 107 17 follow follow VB cord-256784-wfaqim7d 107 18 , , , cord-256784-wfaqim7d 107 19 with with IN cord-256784-wfaqim7d 107 20 MERS MERS NNP cord-256784-wfaqim7d 107 21 - - HYPH cord-256784-wfaqim7d 107 22 CoV CoV NNP cord-256784-wfaqim7d 107 23 highlighted highlight VBD cord-256784-wfaqim7d 107 24 as as IN cord-256784-wfaqim7d 107 25 a a DT cord-256784-wfaqim7d 107 26 case case NN cord-256784-wfaqim7d 107 27 study study NN cord-256784-wfaqim7d 107 28 . . . cord-256784-wfaqim7d 108 1 Although although IN cord-256784-wfaqim7d 108 2 MERS MERS NNP cord-256784-wfaqim7d 108 3 - - HYPH cord-256784-wfaqim7d 108 4 CoV CoV NNP cord-256784-wfaqim7d 108 5 still still RB cord-256784-wfaqim7d 108 6 causes cause VBZ cord-256784-wfaqim7d 108 7 relatively relatively RB cord-256784-wfaqim7d 108 8 few few JJ cord-256784-wfaqim7d 108 9 cases case NNS cord-256784-wfaqim7d 108 10 in in IN cord-256784-wfaqim7d 108 11 a a DT cord-256784-wfaqim7d 108 12 limited limited JJ cord-256784-wfaqim7d 108 13 geographic geographic JJ cord-256784-wfaqim7d 108 14 distribution distribution NN cord-256784-wfaqim7d 108 15 , , , cord-256784-wfaqim7d 108 16 its -PRON- PRP$ cord-256784-wfaqim7d 108 17 high high JJ cord-256784-wfaqim7d 108 18 case case NN cord-256784-wfaqim7d 108 19 fatality fatality NN cord-256784-wfaqim7d 108 20 and and CC cord-256784-wfaqim7d 108 21 sudden sudden JJ cord-256784-wfaqim7d 108 22 outbreak outbreak NN cord-256784-wfaqim7d 108 23 in in IN cord-256784-wfaqim7d 108 24 in in IN cord-256784-wfaqim7d 108 25 Korea Korea NNP cord-256784-wfaqim7d 108 26 have have VBP cord-256784-wfaqim7d 108 27 proven prove VBN cord-256784-wfaqim7d 108 28 it -PRON- PRP cord-256784-wfaqim7d 108 29 to to TO cord-256784-wfaqim7d 108 30 be be VB cord-256784-wfaqim7d 108 31 a a DT cord-256784-wfaqim7d 108 32 pathogen pathogen NN cord-256784-wfaqim7d 108 33 of of IN cord-256784-wfaqim7d 108 34 public public JJ cord-256784-wfaqim7d 108 35 health health NN cord-256784-wfaqim7d 108 36 concern concern NN cord-256784-wfaqim7d 108 37 . . . cord-256784-wfaqim7d 109 1 The the DT cord-256784-wfaqim7d 109 2 concentration concentration NN cord-256784-wfaqim7d 109 3 of of IN cord-256784-wfaqim7d 109 4 the the DT cord-256784-wfaqim7d 109 5 epidemic epidemic NN cord-256784-wfaqim7d 109 6 to to IN cord-256784-wfaqim7d 109 7 Saudi Saudi NNP cord-256784-wfaqim7d 109 8 Arabia Arabia NNP cord-256784-wfaqim7d 109 9 also also RB cord-256784-wfaqim7d 109 10 raises raise VBZ cord-256784-wfaqim7d 109 11 the the DT cord-256784-wfaqim7d 109 12 specter specter NN cord-256784-wfaqim7d 109 13 of of IN cord-256784-wfaqim7d 109 14 international international JJ cord-256784-wfaqim7d 109 15 spread spread NN cord-256784-wfaqim7d 109 16 every every DT cord-256784-wfaqim7d 109 17 year year NN cord-256784-wfaqim7d 109 18 during during IN cord-256784-wfaqim7d 109 19 Hajj Hajj NNP cord-256784-wfaqim7d 109 20 , , , cord-256784-wfaqim7d 109 21 one one CD cord-256784-wfaqim7d 109 22 of of IN cord-256784-wfaqim7d 109 23 the the DT cord-256784-wfaqim7d 109 24 largest large JJS cord-256784-wfaqim7d 109 25 mass mass JJ cord-256784-wfaqim7d 109 26 gathering gathering NN cord-256784-wfaqim7d 109 27 events event NNS cord-256784-wfaqim7d 109 28 in in IN cord-256784-wfaqim7d 109 29 the the DT cord-256784-wfaqim7d 109 30 world world NN cord-256784-wfaqim7d 109 31 . . . cord-256784-wfaqim7d 110 1 Ultimately ultimately RB cord-256784-wfaqim7d 110 2 , , , cord-256784-wfaqim7d 110 3 the the DT cord-256784-wfaqim7d 110 4 development development NN cord-256784-wfaqim7d 110 5 of of IN cord-256784-wfaqim7d 110 6 a a DT cord-256784-wfaqim7d 110 7 safe safe JJ cord-256784-wfaqim7d 110 8 and and CC cord-256784-wfaqim7d 110 9 effective effective JJ cord-256784-wfaqim7d 110 10 vaccine vaccine NN cord-256784-wfaqim7d 110 11 for for IN cord-256784-wfaqim7d 110 12 MERS MERS NNP cord-256784-wfaqim7d 110 13 - - HYPH cord-256784-wfaqim7d 110 14 CoV CoV NNP cord-256784-wfaqim7d 110 15 may may MD cord-256784-wfaqim7d 110 16 not not RB cord-256784-wfaqim7d 110 17 yield yield VB cord-256784-wfaqim7d 110 18 its -PRON- PRP$ cord-256784-wfaqim7d 110 19 greatest great JJS cord-256784-wfaqim7d 110 20 benefit benefit NN cord-256784-wfaqim7d 110 21 for for IN cord-256784-wfaqim7d 110 22 the the DT cord-256784-wfaqim7d 110 23 current current JJ cord-256784-wfaqim7d 110 24 epidemic epidemic NN cord-256784-wfaqim7d 110 25 but but CC cord-256784-wfaqim7d 110 26 for for IN cord-256784-wfaqim7d 110 27 the the DT cord-256784-wfaqim7d 110 28 knowledge knowledge NN cord-256784-wfaqim7d 110 29 gained gain VBN cord-256784-wfaqim7d 110 30 in in IN cord-256784-wfaqim7d 110 31 creating create VBG cord-256784-wfaqim7d 110 32 a a DT cord-256784-wfaqim7d 110 33 platform platform NN cord-256784-wfaqim7d 110 34 for for IN cord-256784-wfaqim7d 110 35 combating combat VBG cord-256784-wfaqim7d 110 36 coronaviruses coronaviruse NNS cord-256784-wfaqim7d 110 37 as as IN cord-256784-wfaqim7d 110 38 a a DT cord-256784-wfaqim7d 110 39 whole whole NN cord-256784-wfaqim7d 110 40 . . . cord-256784-wfaqim7d 111 1 The the DT cord-256784-wfaqim7d 111 2 opinions opinion NNS cord-256784-wfaqim7d 111 3 expressed express VBN cord-256784-wfaqim7d 111 4 herein herein RB cord-256784-wfaqim7d 111 5 are be VBP cord-256784-wfaqim7d 111 6 those those DT cord-256784-wfaqim7d 111 7 of of IN cord-256784-wfaqim7d 111 8 the the DT cord-256784-wfaqim7d 111 9 authors author NNS cord-256784-wfaqim7d 111 10 and and CC cord-256784-wfaqim7d 111 11 should should MD cord-256784-wfaqim7d 111 12 not not RB cord-256784-wfaqim7d 111 13 be be VB cord-256784-wfaqim7d 111 14 construed construe VBN cord-256784-wfaqim7d 111 15 as as IN cord-256784-wfaqim7d 111 16 official official JJ cord-256784-wfaqim7d 111 17 or or CC cord-256784-wfaqim7d 111 18 representing represent VBG cord-256784-wfaqim7d 111 19 the the DT cord-256784-wfaqim7d 111 20 views view NNS cord-256784-wfaqim7d 111 21 of of IN cord-256784-wfaqim7d 111 22 the the DT cord-256784-wfaqim7d 111 23 US US NNP cord-256784-wfaqim7d 111 24 Department Department NNP cord-256784-wfaqim7d 111 25 of of IN cord-256784-wfaqim7d 111 26 Defense Defense NNP cord-256784-wfaqim7d 111 27 or or CC cord-256784-wfaqim7d 111 28 the the DT cord-256784-wfaqim7d 111 29 Department Department NNP cord-256784-wfaqim7d 111 30 of of IN cord-256784-wfaqim7d 111 31 the the DT cord-256784-wfaqim7d 111 32 Army Army NNP cord-256784-wfaqim7d 111 33 . . . cord-256784-wfaqim7d 112 1 Isolation isolation NN cord-256784-wfaqim7d 112 2 of of IN cord-256784-wfaqim7d 112 3 a a DT cord-256784-wfaqim7d 112 4 novel novel JJ cord-256784-wfaqim7d 112 5 coronavirus coronavirus NN cord-256784-wfaqim7d 112 6 from from IN cord-256784-wfaqim7d 112 7 a a DT cord-256784-wfaqim7d 112 8 man man NN cord-256784-wfaqim7d 112 9 with with IN cord-256784-wfaqim7d 112 10 pneumonia pneumonia NN cord-256784-wfaqim7d 112 11 in in IN cord-256784-wfaqim7d 112 12 Saudi Saudi NNP cord-256784-wfaqim7d 112 13 Arabia Arabia NNP cord-256784-wfaqim7d 112 14 epidemiological epidemiological JJ cord-256784-wfaqim7d 112 15 findings finding NNS cord-256784-wfaqim7d 112 16 from from IN cord-256784-wfaqim7d 112 17 a a DT cord-256784-wfaqim7d 112 18 retrospective retrospective JJ cord-256784-wfaqim7d 112 19 investigation investigation NN cord-256784-wfaqim7d 112 20 East East NNP cord-256784-wfaqim7d 112 21 Respiratory Respiratory NNP cord-256784-wfaqim7d 112 22 Syndrome Syndrome NNP cord-256784-wfaqim7d 112 23 Coronavirus Coronavirus NNP cord-256784-wfaqim7d 112 24 ( ( -LRB- cord-256784-wfaqim7d 112 25 MERS MERS NNP cord-256784-wfaqim7d 112 26 - - HYPH cord-256784-wfaqim7d 112 27 CoV CoV NNP cord-256784-wfaqim7d 112 28 ) ) -RRB- cord-256784-wfaqim7d 112 29 Summary Summary NNP cord-256784-wfaqim7d 112 30 and and CC cord-256784-wfaqim7d 112 31 Literature Literature NNP cord-256784-wfaqim7d 112 32 Update update NN cord-256784-wfaqim7d 112 33 - - : cord-256784-wfaqim7d 112 34 as as IN cord-256784-wfaqim7d 112 35 of of IN cord-256784-wfaqim7d 112 36 11 11 CD cord-256784-wfaqim7d 112 37 Update update NN cord-256784-wfaqim7d 112 38 : : : cord-256784-wfaqim7d 112 39 Middle Middle NNP cord-256784-wfaqim7d 112 40 East East NNP cord-256784-wfaqim7d 112 41 Respiratory Respiratory NNP cord-256784-wfaqim7d 112 42 Syndrome Syndrome NNP cord-256784-wfaqim7d 112 43 Coronavirus Coronavirus NNP cord-256784-wfaqim7d 112 44 ( ( -LRB- cord-256784-wfaqim7d 112 45 MERS MERS NNP cord-256784-wfaqim7d 112 46 - - HYPH cord-256784-wfaqim7d 112 47 CoV CoV NNP cord-256784-wfaqim7d 112 48 ) ) -RRB- cord-256784-wfaqim7d 113 1 Probable probable JJ cord-256784-wfaqim7d 113 2 transmission transmission NN cord-256784-wfaqim7d 113 3 chains chain NNS cord-256784-wfaqim7d 113 4 of of IN cord-256784-wfaqim7d 113 5 Middle Middle NNP cord-256784-wfaqim7d 113 6 East East NNP cord-256784-wfaqim7d 113 7 respiratory respiratory JJ cord-256784-wfaqim7d 113 8 syndrome syndrome NN cord-256784-wfaqim7d 113 9 coronavirus coronavirus NN cord-256784-wfaqim7d 113 10 and and CC cord-256784-wfaqim7d 113 11 the the DT cord-256784-wfaqim7d 113 12 multiple multiple JJ cord-256784-wfaqim7d 113 13 generations generation NNS cord-256784-wfaqim7d 113 14 of of IN cord-256784-wfaqim7d 113 15 secondary secondary JJ cord-256784-wfaqim7d 113 16 infection infection NN cord-256784-wfaqim7d 113 17 in in IN cord-256784-wfaqim7d 113 18 South South NNP cord-256784-wfaqim7d 113 19 Korea Korea NNP cord-256784-wfaqim7d 113 20 A A NNP cord-256784-wfaqim7d 113 21 decade decade NN cord-256784-wfaqim7d 113 22 after after IN cord-256784-wfaqim7d 113 23 SARS SARS NNP cord-256784-wfaqim7d 113 24 : : : cord-256784-wfaqim7d 114 1 strategies strategy NNS cord-256784-wfaqim7d 114 2 for for IN cord-256784-wfaqim7d 114 3 controlling control VBG cord-256784-wfaqim7d 114 4 emerging emerge VBG cord-256784-wfaqim7d 114 5 coronaviruses coronaviruse NNS cord-256784-wfaqim7d 114 6 Detection Detection NNP cord-256784-wfaqim7d 114 7 of of IN cord-256784-wfaqim7d 114 8 coronaviruses coronaviruse NNS cord-256784-wfaqim7d 114 9 in in IN cord-256784-wfaqim7d 114 10 bats bat NNS cord-256784-wfaqim7d 114 11 of of IN cord-256784-wfaqim7d 114 12 various various JJ cord-256784-wfaqim7d 114 13 species specie NNS cord-256784-wfaqim7d 114 14 in in IN cord-256784-wfaqim7d 114 15 Italy Italy NNP cord-256784-wfaqim7d 114 16 Diversity Diversity NNP cord-256784-wfaqim7d 114 17 of of IN cord-256784-wfaqim7d 114 18 coronavirus coronavirus NN cord-256784-wfaqim7d 114 19 in in IN cord-256784-wfaqim7d 114 20 bats bat NNS cord-256784-wfaqim7d 114 21 from from IN cord-256784-wfaqim7d 114 22 Eastern Eastern NNP cord-256784-wfaqim7d 114 23 Thailand Thailand NNP cord-256784-wfaqim7d 114 24 MERS MERS NNP cord-256784-wfaqim7d 114 25 - - HYPH cord-256784-wfaqim7d 114 26 related relate VBN cord-256784-wfaqim7d 114 27 betacoronavirus betacoronavirus NN cord-256784-wfaqim7d 114 28 in in IN cord-256784-wfaqim7d 114 29 Vespertilio Vespertilio NNP cord-256784-wfaqim7d 114 30 superans superans NNP cord-256784-wfaqim7d 114 31 bats bat NNS cord-256784-wfaqim7d 114 32 Middle Middle NNP cord-256784-wfaqim7d 114 33 East East NNP cord-256784-wfaqim7d 114 34 respiratory respiratory JJ cord-256784-wfaqim7d 114 35 syndrome syndrome NN cord-256784-wfaqim7d 114 36 coronavirus coronavirus NN cord-256784-wfaqim7d 114 37 infection infection NN cord-256784-wfaqim7d 114 38 in in IN cord-256784-wfaqim7d 114 39 dromedary dromedary NN cord-256784-wfaqim7d 114 40 camels camel NNS cord-256784-wfaqim7d 114 41 in in IN cord-256784-wfaqim7d 114 42 Saudi Saudi NNP cord-256784-wfaqim7d 114 43 Arabia Arabia NNP cord-256784-wfaqim7d 114 44 Middle Middle NNP cord-256784-wfaqim7d 114 45 East East NNP cord-256784-wfaqim7d 114 46 respiratory respiratory JJ cord-256784-wfaqim7d 114 47 syndrome syndrome NN cord-256784-wfaqim7d 114 48 coronavirus coronavirus NN cord-256784-wfaqim7d 114 49 antibody antibody NN cord-256784-wfaqim7d 114 50 reactors reactor NNS cord-256784-wfaqim7d 114 51 among among IN cord-256784-wfaqim7d 114 52 camels camel NNS cord-256784-wfaqim7d 114 53 in in IN cord-256784-wfaqim7d 114 54 Dubai Dubai NNP cord-256784-wfaqim7d 114 55 Antibodies Antibodies NNPS cord-256784-wfaqim7d 114 56 against against IN cord-256784-wfaqim7d 114 57 MERS MERS NNP cord-256784-wfaqim7d 114 58 coronavirus coronavirus NN cord-256784-wfaqim7d 114 59 in in IN cord-256784-wfaqim7d 114 60 dromedary dromedary NN cord-256784-wfaqim7d 114 61 camels camel NNS cord-256784-wfaqim7d 114 62 MERS MERS NNP cord-256784-wfaqim7d 114 63 coronavirus coronavirus NN cord-256784-wfaqim7d 114 64 in in IN cord-256784-wfaqim7d 114 65 dromedary dromedary NN cord-256784-wfaqim7d 114 66 camel camel NN cord-256784-wfaqim7d 114 67 herd herd NN cord-256784-wfaqim7d 114 68 , , . cord-256784-wfaqim7d 115 1 Saudi Saudi NNP cord-256784-wfaqim7d 115 2 Arabia Arabia NNP cord-256784-wfaqim7d 115 3 Evidence evidence NN cord-256784-wfaqim7d 115 4 for for IN cord-256784-wfaqim7d 115 5 camel camel NN cord-256784-wfaqim7d 115 6 - - HYPH cord-256784-wfaqim7d 115 7 to to IN cord-256784-wfaqim7d 115 8 - - HYPH cord-256784-wfaqim7d 115 9 human human JJ cord-256784-wfaqim7d 115 10 transmission transmission NN cord-256784-wfaqim7d 115 11 of of IN cord-256784-wfaqim7d 115 12 MERS MERS NNP cord-256784-wfaqim7d 115 13 coronavirus coronavirus NN cord-256784-wfaqim7d 115 14 MERS MERS NNPS cord-256784-wfaqim7d 115 15 : : : cord-256784-wfaqim7d 115 16 emergence emergence NN cord-256784-wfaqim7d 115 17 of of IN cord-256784-wfaqim7d 115 18 a a DT cord-256784-wfaqim7d 115 19 novel novel JJ cord-256784-wfaqim7d 115 20 human human JJ cord-256784-wfaqim7d 115 21 coronavirus coronavirus NN cord-256784-wfaqim7d 115 22 Molecular molecular JJ cord-256784-wfaqim7d 115 23 basis basis NN cord-256784-wfaqim7d 115 24 of of IN cord-256784-wfaqim7d 115 25 binding bind VBG cord-256784-wfaqim7d 115 26 between between IN cord-256784-wfaqim7d 115 27 novel novel JJ cord-256784-wfaqim7d 115 28 human human JJ cord-256784-wfaqim7d 115 29 coronavirus coronavirus NN cord-256784-wfaqim7d 115 30 MERS MERS NNP cord-256784-wfaqim7d 115 31 - - HYPH cord-256784-wfaqim7d 115 32 CoV CoV NNP cord-256784-wfaqim7d 115 33 and and CC cord-256784-wfaqim7d 115 34 its -PRON- PRP$ cord-256784-wfaqim7d 115 35 receptor receptor NN cord-256784-wfaqim7d 115 36 CD26 CD26 NNP cord-256784-wfaqim7d 115 37 Inhibition Inhibition NNP cord-256784-wfaqim7d 115 38 of of IN cord-256784-wfaqim7d 115 39 Middle Middle NNP cord-256784-wfaqim7d 115 40 East East NNP cord-256784-wfaqim7d 115 41 respiratory respiratory JJ cord-256784-wfaqim7d 115 42 syndrome syndrome NN cord-256784-wfaqim7d 115 43 coronavirus coronavirus NN cord-256784-wfaqim7d 115 44 infection infection NN cord-256784-wfaqim7d 115 45 by by IN cord-256784-wfaqim7d 115 46 anti anti JJ cord-256784-wfaqim7d 115 47 - - JJ cord-256784-wfaqim7d 115 48 CD26 cd26 JJ cord-256784-wfaqim7d 115 49 monoclonal monoclonal JJ cord-256784-wfaqim7d 115 50 antibody antibody NN cord-256784-wfaqim7d 115 51 Update update NN cord-256784-wfaqim7d 115 52 : : : cord-256784-wfaqim7d 115 53 severe severe JJ cord-256784-wfaqim7d 115 54 respiratory respiratory JJ cord-256784-wfaqim7d 115 55 illness illness NN cord-256784-wfaqim7d 115 56 associated associate VBN cord-256784-wfaqim7d 115 57 with with IN cord-256784-wfaqim7d 115 58 Middle Middle NNP cord-256784-wfaqim7d 115 59 East East NNP cord-256784-wfaqim7d 115 60 respiratory respiratory JJ cord-256784-wfaqim7d 115 61 syndrome syndrome NN cord-256784-wfaqim7d 115 62 coronavirus coronavirus NN cord-256784-wfaqim7d 115 63 ( ( -LRB- cord-256784-wfaqim7d 115 64 MERS MERS NNP cord-256784-wfaqim7d 115 65 - - HYPH cord-256784-wfaqim7d 115 66 CoV)-worldwide CoV)-worldwide NNP cord-256784-wfaqim7d 115 67 Middle Middle NNP cord-256784-wfaqim7d 115 68 East East NNP cord-256784-wfaqim7d 115 69 respiratory respiratory JJ cord-256784-wfaqim7d 115 70 syndrome syndrome NN cord-256784-wfaqim7d 115 71 coronavirus coronavirus NN cord-256784-wfaqim7d 115 72 ( ( -LRB- cord-256784-wfaqim7d 115 73 MERS MERS NNP cord-256784-wfaqim7d 115 74 - - HYPH cord-256784-wfaqim7d 115 75 CoV CoV NNP cord-256784-wfaqim7d 115 76 ) ) -RRB- cord-256784-wfaqim7d 115 77 causes cause VBZ cord-256784-wfaqim7d 115 78 transient transient JJ cord-256784-wfaqim7d 115 79 lower low JJR cord-256784-wfaqim7d 115 80 respiratory respiratory JJ cord-256784-wfaqim7d 115 81 tract tract NN cord-256784-wfaqim7d 115 82 infection infection NN cord-256784-wfaqim7d 115 83 in in IN cord-256784-wfaqim7d 115 84 rhesus rhesus NN cord-256784-wfaqim7d 115 85 macaques macaque NNS cord-256784-wfaqim7d 115 86 Middle Middle NNP cord-256784-wfaqim7d 115 87 East East NNP cord-256784-wfaqim7d 115 88 respiratory respiratory JJ cord-256784-wfaqim7d 115 89 syndrome syndrome NN cord-256784-wfaqim7d 115 90 novel novel NN cord-256784-wfaqim7d 115 91 corona corona NNP cord-256784-wfaqim7d 115 92 MERS MERS NNP cord-256784-wfaqim7d 115 93 - - HYPH cord-256784-wfaqim7d 115 94 CoV CoV NNP cord-256784-wfaqim7d 115 95 infection infection NN cord-256784-wfaqim7d 115 96 . . . cord-256784-wfaqim7d 116 1 Epidemiology epidemiology NN cord-256784-wfaqim7d 116 2 and and CC cord-256784-wfaqim7d 116 3 outcome outcome NN cord-256784-wfaqim7d 116 4 update update NN cord-256784-wfaqim7d 116 5 Epidemiological epidemiological JJ cord-256784-wfaqim7d 116 6 , , , cord-256784-wfaqim7d 116 7 demographic demographic JJ cord-256784-wfaqim7d 116 8 , , , cord-256784-wfaqim7d 116 9 and and CC cord-256784-wfaqim7d 116 10 clinical clinical JJ cord-256784-wfaqim7d 116 11 characteristics characteristic NNS cord-256784-wfaqim7d 116 12 of of IN cord-256784-wfaqim7d 116 13 47 47 CD cord-256784-wfaqim7d 116 14 cases case NNS cord-256784-wfaqim7d 116 15 of of IN cord-256784-wfaqim7d 116 16 Middle Middle NNP cord-256784-wfaqim7d 116 17 East East NNP cord-256784-wfaqim7d 116 18 respiratory respiratory JJ cord-256784-wfaqim7d 116 19 syndrome syndrome NN cord-256784-wfaqim7d 116 20 coronavirus coronavirus NN cord-256784-wfaqim7d 116 21 disease disease NN cord-256784-wfaqim7d 116 22 from from IN cord-256784-wfaqim7d 116 23 Saudi Saudi NNP cord-256784-wfaqim7d 116 24 Arabia Arabia NNP cord-256784-wfaqim7d 116 25 : : : cord-256784-wfaqim7d 117 1 a a DT cord-256784-wfaqim7d 117 2 descriptive descriptive JJ cord-256784-wfaqim7d 117 3 study study NN cord-256784-wfaqim7d 117 4 Treatment treatment NN cord-256784-wfaqim7d 117 5 with with IN cord-256784-wfaqim7d 117 6 interferon interferon NN cord-256784-wfaqim7d 117 7 - - HYPH cord-256784-wfaqim7d 117 8 alpha2b alpha2b NNP cord-256784-wfaqim7d 117 9 and and CC cord-256784-wfaqim7d 117 10 ribavirin ribavirin NNP cord-256784-wfaqim7d 117 11 improves improve VBZ cord-256784-wfaqim7d 117 12 outcome outcome NN cord-256784-wfaqim7d 117 13 in in IN cord-256784-wfaqim7d 117 14 MERS MERS NNP cord-256784-wfaqim7d 117 15 - - HYPH cord-256784-wfaqim7d 117 16 CoV CoV NNP cord-256784-wfaqim7d 117 17 - - HYPH cord-256784-wfaqim7d 117 18 infected infect VBN cord-256784-wfaqim7d 117 19 rhesus rhesu NNS cord-256784-wfaqim7d 117 20 macaques macaque NNS cord-256784-wfaqim7d 118 1 The the DT cord-256784-wfaqim7d 118 2 effectiveness effectiveness NN cord-256784-wfaqim7d 118 3 of of IN cord-256784-wfaqim7d 118 4 convalescent convalescent JJ cord-256784-wfaqim7d 118 5 plasma plasma NN cord-256784-wfaqim7d 118 6 and and CC cord-256784-wfaqim7d 118 7 hyperimmune hyperimmune NNP cord-256784-wfaqim7d 118 8 immunoglobulin immunoglobulin NN cord-256784-wfaqim7d 118 9 for for IN cord-256784-wfaqim7d 118 10 the the DT cord-256784-wfaqim7d 118 11 treatment treatment NN cord-256784-wfaqim7d 118 12 of of IN cord-256784-wfaqim7d 118 13 severe severe JJ cord-256784-wfaqim7d 118 14 acute acute JJ cord-256784-wfaqim7d 118 15 respiratory respiratory JJ cord-256784-wfaqim7d 118 16 infections infection NNS cord-256784-wfaqim7d 118 17 of of IN cord-256784-wfaqim7d 118 18 viral viral JJ cord-256784-wfaqim7d 118 19 etiology etiology NN cord-256784-wfaqim7d 118 20 : : : cord-256784-wfaqim7d 118 21 a a DT cord-256784-wfaqim7d 118 22 systematic systematic JJ cord-256784-wfaqim7d 118 23 review review NN cord-256784-wfaqim7d 118 24 and and CC cord-256784-wfaqim7d 118 25 exploratory exploratory JJ cord-256784-wfaqim7d 118 26 meta meta JJ cord-256784-wfaqim7d 118 27 - - HYPH cord-256784-wfaqim7d 118 28 analysis analysis NN cord-256784-wfaqim7d 118 29 Anti Anti NNP cord-256784-wfaqim7d 118 30 - - NNP cord-256784-wfaqim7d 118 31 SARS SARS NNP cord-256784-wfaqim7d 118 32 coronavirus coronavirus NN cord-256784-wfaqim7d 118 33 agents agent NNS cord-256784-wfaqim7d 118 34 : : : cord-256784-wfaqim7d 118 35 a a DT cord-256784-wfaqim7d 118 36 patent patent NN cord-256784-wfaqim7d 118 37 review review NN cord-256784-wfaqim7d 118 38 ( ( -LRB- cord-256784-wfaqim7d 118 39 2008-present 2008-present CD cord-256784-wfaqim7d 118 40 ) ) -RRB- cord-256784-wfaqim7d 118 41 Evaluation evaluation NN cord-256784-wfaqim7d 118 42 of of IN cord-256784-wfaqim7d 118 43 candidate candidate NN cord-256784-wfaqim7d 118 44 vaccine vaccine NN cord-256784-wfaqim7d 118 45 approaches approach VBZ cord-256784-wfaqim7d 118 46 for for IN cord-256784-wfaqim7d 118 47 MERS MERS NNP cord-256784-wfaqim7d 118 48 - - HYPH cord-256784-wfaqim7d 118 49 CoV CoV NNP cord-256784-wfaqim7d 118 50 A a DT cord-256784-wfaqim7d 118 51 truncated truncated JJ cord-256784-wfaqim7d 118 52 receptor receptor NN cord-256784-wfaqim7d 118 53 - - HYPH cord-256784-wfaqim7d 118 54 binding bind VBG cord-256784-wfaqim7d 118 55 domain domain NN cord-256784-wfaqim7d 118 56 of of IN cord-256784-wfaqim7d 118 57 MERS MERS NNP cord-256784-wfaqim7d 118 58 - - HYPH cord-256784-wfaqim7d 118 59 CoV CoV NNP cord-256784-wfaqim7d 118 60 spike spike NN cord-256784-wfaqim7d 118 61 protein protein NN cord-256784-wfaqim7d 118 62 potently potently RB cord-256784-wfaqim7d 118 63 inhibits inhibit VBZ cord-256784-wfaqim7d 118 64 MERS MERS NNP cord-256784-wfaqim7d 118 65 - - HYPH cord-256784-wfaqim7d 118 66 CoV cov NN cord-256784-wfaqim7d 118 67 infection infection NN cord-256784-wfaqim7d 118 68 and and CC cord-256784-wfaqim7d 118 69 induces induce VBZ cord-256784-wfaqim7d 118 70 strong strong JJ cord-256784-wfaqim7d 118 71 neutralizing neutralize VBG cord-256784-wfaqim7d 118 72 antibody antibody NN cord-256784-wfaqim7d 118 73 responses response NNS cord-256784-wfaqim7d 118 74 : : : cord-256784-wfaqim7d 118 75 implication implication NN cord-256784-wfaqim7d 118 76 for for IN cord-256784-wfaqim7d 118 77 developing develop VBG cord-256784-wfaqim7d 118 78 therapeutics therapeutic NNS cord-256784-wfaqim7d 118 79 and and CC cord-256784-wfaqim7d 118 80 vaccines vaccine NNS cord-256784-wfaqim7d 118 81 Intranasal Intranasal NNP cord-256784-wfaqim7d 118 82 vaccination vaccination NN cord-256784-wfaqim7d 118 83 with with IN cord-256784-wfaqim7d 118 84 recombinant recombinant JJ cord-256784-wfaqim7d 118 85 receptor receptor NN cord-256784-wfaqim7d 118 86 - - HYPH cord-256784-wfaqim7d 118 87 binding bind VBG cord-256784-wfaqim7d 118 88 domain domain NN cord-256784-wfaqim7d 118 89 of of IN cord-256784-wfaqim7d 118 90 MERS MERS NNP cord-256784-wfaqim7d 118 91 - - HYPH cord-256784-wfaqim7d 118 92 CoV CoV NNP cord-256784-wfaqim7d 118 93 spike spike NN cord-256784-wfaqim7d 118 94 protein protein NN cord-256784-wfaqim7d 118 95 induces induce VBZ cord-256784-wfaqim7d 118 96 much much RB cord-256784-wfaqim7d 118 97 stronger strong JJR cord-256784-wfaqim7d 118 98 local local JJ cord-256784-wfaqim7d 118 99 mucosal mucosal JJ cord-256784-wfaqim7d 118 100 immune immune JJ cord-256784-wfaqim7d 118 101 responses response NNS cord-256784-wfaqim7d 118 102 than than IN cord-256784-wfaqim7d 118 103 subcutaneous subcutaneous JJ cord-256784-wfaqim7d 118 104 immunization immunization NN cord-256784-wfaqim7d 118 105 : : : cord-256784-wfaqim7d 118 106 Implication implication NN cord-256784-wfaqim7d 118 107 for for IN cord-256784-wfaqim7d 118 108 designing design VBG cord-256784-wfaqim7d 118 109 novel novel JJ cord-256784-wfaqim7d 118 110 mucosal mucosal JJ cord-256784-wfaqim7d 118 111 MERS MERS NNP cord-256784-wfaqim7d 118 112 vaccines vaccine NNS cord-256784-wfaqim7d 118 113 Optimization Optimization NNP cord-256784-wfaqim7d 118 114 of of IN cord-256784-wfaqim7d 118 115 antigen antigen NN cord-256784-wfaqim7d 118 116 dose dose NN cord-256784-wfaqim7d 118 117 for for IN cord-256784-wfaqim7d 118 118 a a DT cord-256784-wfaqim7d 118 119 receptor receptor NN cord-256784-wfaqim7d 118 120 - - HYPH cord-256784-wfaqim7d 118 121 binding bind VBG cord-256784-wfaqim7d 118 122 domain domain NN cord-256784-wfaqim7d 118 123 - - HYPH cord-256784-wfaqim7d 118 124 based base VBN cord-256784-wfaqim7d 118 125 subunit subunit NN cord-256784-wfaqim7d 118 126 vaccine vaccine NN cord-256784-wfaqim7d 118 127 against against IN cord-256784-wfaqim7d 118 128 MERS MERS NNP cord-256784-wfaqim7d 118 129 coronavirus coronavirus NN cord-256784-wfaqim7d 118 130 Receptor receptor NN cord-256784-wfaqim7d 118 131 - - HYPH cord-256784-wfaqim7d 118 132 binding bind VBG cord-256784-wfaqim7d 118 133 domain domain NN cord-256784-wfaqim7d 118 134 - - HYPH cord-256784-wfaqim7d 118 135 based base VBN cord-256784-wfaqim7d 118 136 subunit subunit NN cord-256784-wfaqim7d 118 137 vaccines vaccine NNS cord-256784-wfaqim7d 118 138 against against IN cord-256784-wfaqim7d 118 139 MERS MERS NNP cord-256784-wfaqim7d 118 140 - - HYPH cord-256784-wfaqim7d 118 141 CoV CoV NNP cord-256784-wfaqim7d 118 142 Crystal Crystal NNP cord-256784-wfaqim7d 118 143 structure structure NN cord-256784-wfaqim7d 118 144 of of IN cord-256784-wfaqim7d 118 145 the the DT cord-256784-wfaqim7d 118 146 receptor receptor NN cord-256784-wfaqim7d 118 147 - - HYPH cord-256784-wfaqim7d 118 148 binding bind VBG cord-256784-wfaqim7d 118 149 domain domain NN cord-256784-wfaqim7d 118 150 from from IN cord-256784-wfaqim7d 118 151 newly newly RB cord-256784-wfaqim7d 118 152 emerged emerge VBN cord-256784-wfaqim7d 118 153 Middle Middle NNP cord-256784-wfaqim7d 118 154 East East NNP cord-256784-wfaqim7d 118 155 respiratory respiratory JJ cord-256784-wfaqim7d 118 156 syndrome syndrome NN cord-256784-wfaqim7d 118 157 coronavirus coronavirus NN cord-256784-wfaqim7d 118 158 Structure Structure NNP cord-256784-wfaqim7d 118 159 of of IN cord-256784-wfaqim7d 118 160 MERS MERS NNP cord-256784-wfaqim7d 118 161 - - HYPH cord-256784-wfaqim7d 118 162 CoV CoV NNP cord-256784-wfaqim7d 118 163 spike spike NN cord-256784-wfaqim7d 118 164 receptor receptor NN cord-256784-wfaqim7d 118 165 - - HYPH cord-256784-wfaqim7d 118 166 binding bind VBG cord-256784-wfaqim7d 118 167 domain domain NN cord-256784-wfaqim7d 118 168 complexed complexe VBN cord-256784-wfaqim7d 118 169 with with IN cord-256784-wfaqim7d 118 170 human human JJ cord-256784-wfaqim7d 118 171 receptor receptor NN cord-256784-wfaqim7d 118 172 DPP4 DPP4 NNP cord-256784-wfaqim7d 118 173 Effects effect NNS cord-256784-wfaqim7d 118 174 of of IN cord-256784-wfaqim7d 118 175 human human JJ cord-256784-wfaqim7d 118 176 anti anti JJ cord-256784-wfaqim7d 118 177 - - JJ cord-256784-wfaqim7d 118 178 spike spike JJ cord-256784-wfaqim7d 118 179 protein protein NN cord-256784-wfaqim7d 118 180 receptor receptor NN cord-256784-wfaqim7d 118 181 binding bind VBG cord-256784-wfaqim7d 118 182 domain domain NN cord-256784-wfaqim7d 118 183 antibodies antibody NNS cord-256784-wfaqim7d 118 184 on on IN cord-256784-wfaqim7d 118 185 severe severe JJ cord-256784-wfaqim7d 118 186 acute acute JJ cord-256784-wfaqim7d 118 187 respiratory respiratory JJ cord-256784-wfaqim7d 118 188 syndrome syndrome NN cord-256784-wfaqim7d 118 189 coronavirus coronavirus NN cord-256784-wfaqim7d 118 190 neutralization neutralization NN cord-256784-wfaqim7d 118 191 escape escape NN cord-256784-wfaqim7d 118 192 and and CC cord-256784-wfaqim7d 118 193 fitness fitness NN cord-256784-wfaqim7d 118 194 Purified purify VBN cord-256784-wfaqim7d 118 195 coronavirus coronavirus NN cord-256784-wfaqim7d 118 196 spike spike NN cord-256784-wfaqim7d 118 197 protein protein NN cord-256784-wfaqim7d 118 198 nanoparticles nanoparticle NNS cord-256784-wfaqim7d 118 199 induce induce VBP cord-256784-wfaqim7d 118 200 coronavirus coronavirus NN cord-256784-wfaqim7d 118 201 neutralizing neutralize VBG cord-256784-wfaqim7d 118 202 antibodies antibody NNS cord-256784-wfaqim7d 118 203 in in IN cord-256784-wfaqim7d 118 204 mice mouse NNS cord-256784-wfaqim7d 118 205 Engineering engineer VBG cord-256784-wfaqim7d 118 206 a a DT cord-256784-wfaqim7d 118 207 replication replication NN cord-256784-wfaqim7d 118 208 - - HYPH cord-256784-wfaqim7d 118 209 competent competent JJ cord-256784-wfaqim7d 118 210 , , , cord-256784-wfaqim7d 118 211 propagation propagation NN cord-256784-wfaqim7d 118 212 - - HYPH cord-256784-wfaqim7d 118 213 defective defective JJ cord-256784-wfaqim7d 118 214 Middle Middle NNP cord-256784-wfaqim7d 118 215 East East NNP cord-256784-wfaqim7d 118 216 respiratory respiratory JJ cord-256784-wfaqim7d 118 217 syndrome syndrome NN cord-256784-wfaqim7d 118 218 coronavirus coronavirus NN cord-256784-wfaqim7d 118 219 as as IN cord-256784-wfaqim7d 118 220 a a DT cord-256784-wfaqim7d 118 221 vaccine vaccine NN cord-256784-wfaqim7d 118 222 candidate candidate NN cord-256784-wfaqim7d 118 223 Middle Middle NNP cord-256784-wfaqim7d 118 224 East East NNP cord-256784-wfaqim7d 118 225 respiratory respiratory JJ cord-256784-wfaqim7d 118 226 syndrome syndrome NN cord-256784-wfaqim7d 118 227 coronavirus coronavirus NN cord-256784-wfaqim7d 118 228 spike spike NN cord-256784-wfaqim7d 118 229 protein protein NN cord-256784-wfaqim7d 118 230 delivered deliver VBN cord-256784-wfaqim7d 118 231 by by IN cord-256784-wfaqim7d 118 232 modified modify VBN cord-256784-wfaqim7d 118 233 vaccinia vaccinia NN cord-256784-wfaqim7d 118 234 virus virus NN cord-256784-wfaqim7d 119 1 Ankara Ankara NNP cord-256784-wfaqim7d 119 2 efficiently efficiently RB cord-256784-wfaqim7d 119 3 induces induce VBZ cord-256784-wfaqim7d 119 4 virus virus NN cord-256784-wfaqim7d 119 5 - - HYPH cord-256784-wfaqim7d 119 6 neutralizing neutralize VBG cord-256784-wfaqim7d 119 7 antibodies antibody NNS cord-256784-wfaqim7d 119 8 Protective protective JJ cord-256784-wfaqim7d 119 9 efficacy efficacy NN cord-256784-wfaqim7d 119 10 of of IN cord-256784-wfaqim7d 119 11 recombinant recombinant JJ cord-256784-wfaqim7d 119 12 modified modify VBN cord-256784-wfaqim7d 119 13 vaccinia vaccinia NN cord-256784-wfaqim7d 119 14 virus virus NN cord-256784-wfaqim7d 119 15 Ankara Ankara NNP cord-256784-wfaqim7d 119 16 delivering deliver VBG cord-256784-wfaqim7d 119 17 Middle Middle NNP cord-256784-wfaqim7d 119 18 East East NNP cord-256784-wfaqim7d 119 19 respiratory respiratory JJ cord-256784-wfaqim7d 119 20 syndrome syndrome NN cord-256784-wfaqim7d 119 21 coronavirus coronavirus NN cord-256784-wfaqim7d 119 22 spike spike NN cord-256784-wfaqim7d 119 23 glycoprotein glycoprotein NN cord-256784-wfaqim7d 119 24 Systemic systemic JJ cord-256784-wfaqim7d 119 25 and and CC cord-256784-wfaqim7d 119 26 mucosal mucosal JJ cord-256784-wfaqim7d 119 27 immunity immunity NN cord-256784-wfaqim7d 119 28 in in IN cord-256784-wfaqim7d 119 29 mice mouse NNS cord-256784-wfaqim7d 119 30 elicited elicit VBN cord-256784-wfaqim7d 119 31 by by IN cord-256784-wfaqim7d 119 32 a a DT cord-256784-wfaqim7d 119 33 single single JJ cord-256784-wfaqim7d 119 34 immunization immunization NN cord-256784-wfaqim7d 119 35 with with IN cord-256784-wfaqim7d 119 36 human human JJ cord-256784-wfaqim7d 119 37 adenovirus adenovirus NN cord-256784-wfaqim7d 119 38 type type NN cord-256784-wfaqim7d 119 39 5 5 CD cord-256784-wfaqim7d 119 40 or or CC cord-256784-wfaqim7d 119 41 41 41 CD cord-256784-wfaqim7d 119 42 vector vector NN cord-256784-wfaqim7d 119 43 - - HYPH cord-256784-wfaqim7d 119 44 based base VBN cord-256784-wfaqim7d 119 45 vaccines vaccine NNS cord-256784-wfaqim7d 119 46 carrying carry VBG cord-256784-wfaqim7d 119 47 the the DT cord-256784-wfaqim7d 119 48 spike spike NN cord-256784-wfaqim7d 119 49 protein protein NN cord-256784-wfaqim7d 119 50 of of IN cord-256784-wfaqim7d 119 51 Middle Middle NNP cord-256784-wfaqim7d 119 52 East East NNP cord-256784-wfaqim7d 119 53 respiratory respiratory JJ cord-256784-wfaqim7d 119 54 syndrome syndrome NN cord-256784-wfaqim7d 119 55 coronavirus coronavirus NN cord-256784-wfaqim7d 119 56 Immunogenicity Immunogenicity NNP cord-256784-wfaqim7d 119 57 of of IN cord-256784-wfaqim7d 119 58 an an DT cord-256784-wfaqim7d 119 59 adenoviral adenoviral NN cord-256784-wfaqim7d 119 60 - - HYPH cord-256784-wfaqim7d 119 61 based base VBN cord-256784-wfaqim7d 119 62 Middle Middle NNP cord-256784-wfaqim7d 119 63 East East NNP cord-256784-wfaqim7d 119 64 respiratory respiratory JJ cord-256784-wfaqim7d 119 65 syndrome syndrome NN cord-256784-wfaqim7d 119 66 coronavirus coronavirus NN cord-256784-wfaqim7d 119 67 vaccine vaccine NN cord-256784-wfaqim7d 119 68 in in IN cord-256784-wfaqim7d 119 69 BALB BALB NNP cord-256784-wfaqim7d 119 70 / / SYM cord-256784-wfaqim7d 119 71 c c NN cord-256784-wfaqim7d 119 72 mice mouse NNS cord-256784-wfaqim7d 119 73 Estimation Estimation NNP cord-256784-wfaqim7d 119 74 of of IN cord-256784-wfaqim7d 119 75 MERS MERS NNP cord-256784-wfaqim7d 119 76 - - HYPH cord-256784-wfaqim7d 119 77 coronavirus coronavirus NN cord-256784-wfaqim7d 119 78 reproductive reproductive JJ cord-256784-wfaqim7d 119 79 number number NN cord-256784-wfaqim7d 119 80 and and CC cord-256784-wfaqim7d 119 81 case case NN cord-256784-wfaqim7d 119 82 fatality fatality NN cord-256784-wfaqim7d 119 83 rate rate NN cord-256784-wfaqim7d 119 84 for for IN cord-256784-wfaqim7d 119 85 the the DT cord-256784-wfaqim7d 119 86 spring spring NN cord-256784-wfaqim7d 119 87 2014 2014 CD cord-256784-wfaqim7d 119 88 Saudi Saudi NNP cord-256784-wfaqim7d 119 89 Arabia Arabia NNP cord-256784-wfaqim7d 119 90 outbreak outbreak NN cord-256784-wfaqim7d 119 91 : : : cord-256784-wfaqim7d 119 92 insights insight NNS cord-256784-wfaqim7d 119 93 from from IN cord-256784-wfaqim7d 119 94 publicly publicly RB cord-256784-wfaqim7d 119 95 available available JJ cord-256784-wfaqim7d 119 96 data datum NNS cord-256784-wfaqim7d 120 1 Distinct distinct JJ cord-256784-wfaqim7d 120 2 immune immune JJ cord-256784-wfaqim7d 120 3 response response NN cord-256784-wfaqim7d 120 4 in in IN cord-256784-wfaqim7d 120 5 two two CD cord-256784-wfaqim7d 120 6 MERS MERS NNP cord-256784-wfaqim7d 120 7 - - HYPH cord-256784-wfaqim7d 120 8 CoV cov NN cord-256784-wfaqim7d 120 9 - - HYPH cord-256784-wfaqim7d 120 10 infected infect VBN cord-256784-wfaqim7d 120 11 patients patient NNS cord-256784-wfaqim7d 120 12 : : : cord-256784-wfaqim7d 120 13 can can MD cord-256784-wfaqim7d 120 14 we -PRON- PRP cord-256784-wfaqim7d 120 15 go go VB cord-256784-wfaqim7d 120 16 from from IN cord-256784-wfaqim7d 120 17 bench bench NN cord-256784-wfaqim7d 120 18 to to IN cord-256784-wfaqim7d 120 19 bedside bedside NN cord-256784-wfaqim7d 120 20 ? ? . cord-256784-wfaqim7d 121 1 Potent potent JJ cord-256784-wfaqim7d 121 2 neutralization neutralization NN cord-256784-wfaqim7d 121 3 of of IN cord-256784-wfaqim7d 121 4 MERS MERS NNP cord-256784-wfaqim7d 121 5 - - HYPH cord-256784-wfaqim7d 121 6 CoV CoV NNP cord-256784-wfaqim7d 121 7 by by IN cord-256784-wfaqim7d 121 8 human human JJ cord-256784-wfaqim7d 121 9 neutralizing neutralize VBG cord-256784-wfaqim7d 121 10 monoclonal monoclonal JJ cord-256784-wfaqim7d 121 11 antibodies antibody NNS cord-256784-wfaqim7d 121 12 to to IN cord-256784-wfaqim7d 121 13 the the DT cord-256784-wfaqim7d 121 14 viral viral JJ cord-256784-wfaqim7d 121 15 spike spike NN cord-256784-wfaqim7d 121 16 glycoprotein glycoprotein NN cord-256784-wfaqim7d 121 17 Exceptionally exceptionally RB cord-256784-wfaqim7d 121 18 potent potent JJ cord-256784-wfaqim7d 121 19 neutralization neutralization NN cord-256784-wfaqim7d 121 20 of of IN cord-256784-wfaqim7d 121 21 Middle Middle NNP cord-256784-wfaqim7d 121 22 East East NNP cord-256784-wfaqim7d 121 23 respiratory respiratory JJ cord-256784-wfaqim7d 121 24 syndrome syndrome NN cord-256784-wfaqim7d 121 25 coronavirus coronavirus NN cord-256784-wfaqim7d 121 26 by by IN cord-256784-wfaqim7d 121 27 human human JJ cord-256784-wfaqim7d 121 28 monoclonal monoclonal JJ cord-256784-wfaqim7d 121 29 antibodies antibody NNS cord-256784-wfaqim7d 121 30 Identification Identification NNP cord-256784-wfaqim7d 121 31 of of IN cord-256784-wfaqim7d 121 32 human human JJ cord-256784-wfaqim7d 121 33 neutralizing neutralize VBG cord-256784-wfaqim7d 121 34 antibodies antibody NNS cord-256784-wfaqim7d 121 35 against against IN cord-256784-wfaqim7d 121 36 MERS MERS NNP cord-256784-wfaqim7d 121 37 - - HYPH cord-256784-wfaqim7d 121 38 CoV CoV NNP cord-256784-wfaqim7d 121 39 and and CC cord-256784-wfaqim7d 121 40 their -PRON- PRP$ cord-256784-wfaqim7d 121 41 role role NN cord-256784-wfaqim7d 121 42 in in IN cord-256784-wfaqim7d 121 43 virus virus NN cord-256784-wfaqim7d 121 44 adaptive adaptive JJ cord-256784-wfaqim7d 121 45 evolution evolution NN cord-256784-wfaqim7d 121 46 Preand Preand NNP cord-256784-wfaqim7d 121 47 postexposure postexposure NN cord-256784-wfaqim7d 121 48 efficacy efficacy NN cord-256784-wfaqim7d 121 49 of of IN cord-256784-wfaqim7d 121 50 fully fully RB cord-256784-wfaqim7d 121 51 human human JJ cord-256784-wfaqim7d 121 52 antibodies antibody NNS cord-256784-wfaqim7d 121 53 against against IN cord-256784-wfaqim7d 121 54 spike spike NN cord-256784-wfaqim7d 121 55 protein protein NN cord-256784-wfaqim7d 121 56 in in IN cord-256784-wfaqim7d 121 57 a a DT cord-256784-wfaqim7d 121 58 novel novel JJ cord-256784-wfaqim7d 121 59 humanized humanize VBN cord-256784-wfaqim7d 121 60 mouse mouse NN cord-256784-wfaqim7d 121 61 model model NN cord-256784-wfaqim7d 121 62 of of IN cord-256784-wfaqim7d 121 63 MERS MERS NNP cord-256784-wfaqim7d 121 64 - - HYPH cord-256784-wfaqim7d 121 65 CoV CoV NNP cord-256784-wfaqim7d 121 66 infection infection NN cord-256784-wfaqim7d 121 67 Prophylactic prophylactic JJ cord-256784-wfaqim7d 121 68 and and CC cord-256784-wfaqim7d 121 69 postexposure postexposure NN cord-256784-wfaqim7d 121 70 efficacy efficacy NN cord-256784-wfaqim7d 121 71 of of IN cord-256784-wfaqim7d 121 72 a a DT cord-256784-wfaqim7d 121 73 potent potent JJ cord-256784-wfaqim7d 121 74 human human JJ cord-256784-wfaqim7d 121 75 monoclonal monoclonal JJ cord-256784-wfaqim7d 121 76 antibody antibody NN cord-256784-wfaqim7d 121 77 against against IN cord-256784-wfaqim7d 121 78 MERS MERS NNP cord-256784-wfaqim7d 121 79 coronavirus coronavirus NNP cord-256784-wfaqim7d 121 80 Family Family NNP cord-256784-wfaqim7d 121 81 cluster cluster NN cord-256784-wfaqim7d 121 82 of of IN cord-256784-wfaqim7d 121 83 Middle Middle NNP cord-256784-wfaqim7d 121 84 East East NNP cord-256784-wfaqim7d 121 85 respiratory respiratory JJ cord-256784-wfaqim7d 121 86 syndrome syndrome NN cord-256784-wfaqim7d 121 87 coronavirus coronavirus NN cord-256784-wfaqim7d 121 88 infections infection NNS cord-256784-wfaqim7d 121 89 Hospital hospital NN cord-256784-wfaqim7d 121 90 - - HYPH cord-256784-wfaqim7d 121 91 associated associate VBN cord-256784-wfaqim7d 121 92 outbreak outbreak NN cord-256784-wfaqim7d 121 93 of of IN cord-256784-wfaqim7d 121 94 Middle Middle NNP cord-256784-wfaqim7d 121 95 East East NNP cord-256784-wfaqim7d 121 96 respiratory respiratory JJ cord-256784-wfaqim7d 121 97 syndrome syndrome NN cord-256784-wfaqim7d 121 98 coronavirus coronavirus NN cord-256784-wfaqim7d 121 99 : : : cord-256784-wfaqim7d 121 100 a a DT cord-256784-wfaqim7d 121 101 serologic serologic NN cord-256784-wfaqim7d 121 102 , , , cord-256784-wfaqim7d 121 103 epidemiologic epidemiologic JJ cord-256784-wfaqim7d 121 104 , , , cord-256784-wfaqim7d 121 105 and and CC cord-256784-wfaqim7d 121 106 clinical clinical JJ cord-256784-wfaqim7d 121 107 description description NN cord-256784-wfaqim7d 121 108 Middle Middle NNP cord-256784-wfaqim7d 121 109 East East NNP cord-256784-wfaqim7d 121 110 respiratory respiratory JJ cord-256784-wfaqim7d 121 111 syndrome syndrome NN cord-256784-wfaqim7d 121 112 coronavirus coronavirus NN cord-256784-wfaqim7d 121 113 : : : cord-256784-wfaqim7d 121 114 a a DT cord-256784-wfaqim7d 121 115 case case NN cord-256784-wfaqim7d 121 116 - - HYPH cord-256784-wfaqim7d 121 117 control control NN cord-256784-wfaqim7d 121 118 study study NN cord-256784-wfaqim7d 121 119 of of IN cord-256784-wfaqim7d 121 120 hospitalized hospitalize VBN cord-256784-wfaqim7d 121 121 patients patient NNS cord-256784-wfaqim7d 121 122 Hospital Hospital NNP cord-256784-wfaqim7d 121 123 outbreak outbreak NN cord-256784-wfaqim7d 121 124 of of IN cord-256784-wfaqim7d 121 125 Middle Middle NNP cord-256784-wfaqim7d 121 126 East East NNP cord-256784-wfaqim7d 121 127 respiratory respiratory JJ cord-256784-wfaqim7d 121 128 syndrome syndrome NN cord-256784-wfaqim7d 121 129 coronavirus coronavirus NN cord-256784-wfaqim7d 121 130 Hospital Hospital NNP cord-256784-wfaqim7d 121 131 - - HYPH cord-256784-wfaqim7d 121 132 associated associate VBN cord-256784-wfaqim7d 121 133 Middle Middle NNP cord-256784-wfaqim7d 121 134 East East NNP cord-256784-wfaqim7d 121 135 respiratory respiratory JJ cord-256784-wfaqim7d 121 136 syndrome syndrome NN cord-256784-wfaqim7d 121 137 coronavirus coronavirus NN cord-256784-wfaqim7d 121 138 infections infection NNS cord-256784-wfaqim7d 121 139 Hospital Hospital NNP cord-256784-wfaqim7d 121 140 - - HYPH cord-256784-wfaqim7d 121 141 associated associate VBN cord-256784-wfaqim7d 121 142 Middle Middle NNP cord-256784-wfaqim7d 121 143 East East NNP cord-256784-wfaqim7d 121 144 respiratory respiratory JJ cord-256784-wfaqim7d 121 145 syndrome syndrome NN cord-256784-wfaqim7d 121 146 coronavirus coronavirus NN cord-256784-wfaqim7d 121 147 infections infection NNS cord-256784-wfaqim7d 121 148 Hendra Hendra NNP cord-256784-wfaqim7d 121 149 virus virus NN cord-256784-wfaqim7d 121 150 vaccine vaccine NN cord-256784-wfaqim7d 121 151 , , , cord-256784-wfaqim7d 121 152 a a DT cord-256784-wfaqim7d 121 153 one one CD cord-256784-wfaqim7d 121 154 health health NN cord-256784-wfaqim7d 121 155 approach approach NN cord-256784-wfaqim7d 121 156 to to IN cord-256784-wfaqim7d 121 157 protecting protect VBG cord-256784-wfaqim7d 121 158 horse horse NN cord-256784-wfaqim7d 121 159 , , , cord-256784-wfaqim7d 121 160 human human NN cord-256784-wfaqim7d 121 161 , , , cord-256784-wfaqim7d 121 162 and and CC cord-256784-wfaqim7d 121 163 environmental environmental JJ cord-256784-wfaqim7d 121 164 health health NN cord-256784-wfaqim7d 121 165 Hendra Hendra NNP cord-256784-wfaqim7d 121 166 virus virus NN cord-256784-wfaqim7d 122 1 An an DT cord-256784-wfaqim7d 122 2 orthopoxvirus orthopoxvirus NN cord-256784-wfaqim7d 122 3 - - HYPH cord-256784-wfaqim7d 122 4 based base VBN cord-256784-wfaqim7d 122 5 vaccine vaccine NN cord-256784-wfaqim7d 122 6 reduces reduce VBZ cord-256784-wfaqim7d 122 7 virus virus NN cord-256784-wfaqim7d 122 8 excretion excretion NN cord-256784-wfaqim7d 122 9 after after IN cord-256784-wfaqim7d 122 10 MERS MERS NNP cord-256784-wfaqim7d 122 11 - - HYPH cord-256784-wfaqim7d 122 12 CoV cov NN cord-256784-wfaqim7d 122 13 infection infection NN cord-256784-wfaqim7d 122 14 in in IN cord-256784-wfaqim7d 122 15 dromedary dromedary NN cord-256784-wfaqim7d 122 16 camels camel NNS cord-256784-wfaqim7d 122 17 Rapid rapid JJ cord-256784-wfaqim7d 122 18 generation generation NN cord-256784-wfaqim7d 122 19 of of IN cord-256784-wfaqim7d 122 20 a a DT cord-256784-wfaqim7d 122 21 mouse mouse NN cord-256784-wfaqim7d 122 22 model model NN cord-256784-wfaqim7d 122 23 for for IN cord-256784-wfaqim7d 122 24 Middle Middle NNP cord-256784-wfaqim7d 122 25 East East NNP cord-256784-wfaqim7d 122 26 respiratory respiratory JJ cord-256784-wfaqim7d 122 27 syndrome syndrome NN cord-256784-wfaqim7d 122 28 Generation generation NN cord-256784-wfaqim7d 122 29 of of IN cord-256784-wfaqim7d 122 30 a a DT cord-256784-wfaqim7d 122 31 transgenic transgenic JJ cord-256784-wfaqim7d 122 32 mouse mouse NN cord-256784-wfaqim7d 122 33 model model NN cord-256784-wfaqim7d 122 34 of of IN cord-256784-wfaqim7d 122 35 Middle Middle NNP cord-256784-wfaqim7d 122 36 East East NNP cord-256784-wfaqim7d 122 37 respiratory respiratory JJ cord-256784-wfaqim7d 122 38 syndrome syndrome NN cord-256784-wfaqim7d 122 39 coronavirus coronavirus NN cord-256784-wfaqim7d 122 40 infection infection NN cord-256784-wfaqim7d 122 41 and and CC cord-256784-wfaqim7d 122 42 disease disease NN cord-256784-wfaqim7d 122 43 Animal Animal NNP cord-256784-wfaqim7d 122 44 models model NNS cord-256784-wfaqim7d 122 45 of of IN cord-256784-wfaqim7d 122 46 Middle Middle NNP cord-256784-wfaqim7d 122 47 East East NNP cord-256784-wfaqim7d 122 48 respiratory respiratory JJ cord-256784-wfaqim7d 122 49 syndrome syndrome NN cord-256784-wfaqim7d 122 50 coronavirus coronavirus NN cord-256784-wfaqim7d 122 51 infection infection NN