id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342756-rgm9ffpk	Senger, Mario Roberto	COVID-19: molecular targets, drug repurposing and new avenues for drug discovery	2020-10-02		.txt	text/plain	16108	1024	51	Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. In the following topic, we will review SARS-CoV-2 structure and mechanism of infection in order to discuss molecular targets from the virus or its human host that are being considered for drug repurposing and perhaps future development of new drugs. (128) Its role as a functional receptor of SARS-CoV-2 S protein in host cells makes this protein a potential drug target to treat COVID-19. (138) TMPRSS2 has a major role in SARS-CoV-2 cell entry and replication, and thus represents an interesting therapeutic target since its inhibitors could potentially block virus infection in its initial stages. (199) A robust preclinical drug discovery pipeline comprising in vitro, and in vivo models of SARS-CoV-2 infection is particularly important to identify new antivirals for human COVID-19 treatment.	./cache/cord-342756-rgm9ffpk.txt	./txt/cord-342756-rgm9ffpk.txt