id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328175-4i3cz20j	van Doremalen, Neeltje	Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets	2017-07-31		.txt	text/plain	5150	272	51	Abstract Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mAbs) is a potential quick route to an intervention. Here we assess the effect of treatment with marmoset-derived hyperimmune plasma as well as the human mAb m336 on disease outcome in the recently developed marmoset MERS-CoV infection model, which recapitulates severe respiratory disease (Falzarano et al., 2014) . Viral loads in lung tissues from hyperimmune plasma-treated compared to control animals were found to be significantly lower using a onetailed unpaired Student's t-test (average of 4.0 Â 10 4 and 1.2 Â 10 6 TCID 50 equivalent/gram, respectively, p-value ¼ 0.008). In this study, hyperimmune plasma treatment of marmosets inoculated with MERS-CoV resulted in a small (0.5e1 log) but significant reduction in respiratory tract viral loads, as well as reduced disease severity such as observed with radiographs, compared to marmosets treated with non-convalescent plasma or PBS.	./cache/cord-328175-4i3cz20j.txt	./txt/cord-328175-4i3cz20j.txt