id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323533-otosnjde	Ekins, Sean	Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses	2020-04-21		.txt	text/plain	1105	72	51	After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). These results led us to more broadly profile the antiviral spectrum of activity and focus on Chikungunya virus (CHIK) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). Plates are incubated at 37°C with 5% CO 2 until maximum CPE is observed microscopically in virus control wells (CHIK and MERS-CoV were incubated for 3 days). Tilorone has in vitro activity against CHIK and MERS-CoV. We identified promising micromolar activities for tilorone against CHIK and MERS-CoV with reasonable selectivity indexes ( Table 1 ). Recent virus outbreaks such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suggest the urgent need for reassessment of this compound as a broadspectrum antiviral as we have yet to fully appreciate the utility of this drug discovered 50 years ago. Tilorone hydrochloride: an orally active antiviral agent Efficacy of tilorone dihydrochloride against Ebola virus infection	./cache/cord-323533-otosnjde.txt	./txt/cord-323533-otosnjde.txt