id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323093-u3ozc9ry	Rathnayake, Athri D.	3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice	2020-08-19		.txt	text/plain	7158	362	56	After we observed that treatment with compound 6j resulted in the survival of MERS MA -CoV-infected hDPP4-KI mice, we conducted another study by delaying treatment initiation until 3 dpi. This nucleoside analog was originally developed as an antiviral drug against Ebola virus and has been shown to be effective against both MERS-CoV and SARS-CoV in cell culture assays and in animal models of coronavirus infection (23) (24) (25) (26) . Prophylactic treatment or early therapeutic treatment of infected mice with remdesivir reduced MERS-CoV-or SARS-CoV-mediated weight loss and decreased lung virus titers and lung injury scores compared to those of vehicle-treated animals (23, 26) . The goal of this study was to evaluate the efficacy of 3CLpro inhibitors against human coronaviruses, including SARS-CoV-2, in a FRET enzyme assay and cell culture assays, as well as in a mouse model of MERS-CoV infection.	./cache/cord-323093-u3ozc9ry.txt	./txt/cord-323093-u3ozc9ry.txt