id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321918-9jwma2y6	Xiu, Siyu	Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities	2020-06-15		.txt	text/plain	10526	621	52	The spike protein can be divided into two domains; S1 is responsible for angiotensin-converting enzyme II(ACE2) recognition, the recently identified host cell receptor, and S2 mediates membrane fusion (Figure 2 ). 98 99 On the basis of this approach, they identified two small molecules, TGG (12, Table 4 ) and luteolin (13) , that can bind avidly to the SARS-CoV S2 protein and inhibit viral entry of SARS-CoV into Vero E6 cells with IC 50 values of 4.5 and 10.6 μM, respectively. 113 A high-throughput screen (HTS) of a 1000-compound library that resulted in the identification of MDL28170 (17 , Table 4 ) by Bates et al., and in an antiviral activity assay, 17 specifically inhibited cathepsin L-mediated substrate cleavage and blocked SARS-CoV viral entry, with an IC 50 value of 2.5 nM and EC 50 value in the range of 100 nM.	./cache/cord-321918-9jwma2y6.txt	./txt/cord-321918-9jwma2y6.txt