id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320238-qbjrlog1	Okba, Nisreen M. A.	Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV	2020-05-29		.txt	text/plain	6185	291	48	Using an immune-focusing approach, we created self-assembling particles multivalently displaying critical regions of the MERS-CoV spike protein ─fusion peptide, heptad repeat 2, and receptor binding domain (RBD) ─ and tested their immunogenicity and protective capacity in rabbits. The use of self-assembling multimeric protein scaffold particles (MPSP) to present antigens in a multivalent virus-mimicking manner (size, repetitiveness, and geometry), has been shown to enhance vaccine-induced immune responses [7] [8] [9] [10] [11] , and to offer advantages over other multimeric antigen presentation platforms (reviewed in [12] ). We sought to design antigens capable of inducing strong immune responses against critical parts of the viral entry and fusion machinery within the MERS-CoV spike protein through immune focusing and multivalent presentation on self-assembling particles (Figure 1 ). Following the prime, RBD-LS vaccination induced antibody responses of high avidity and MERS-CoV neutralizing capacity.	./cache/cord-320238-qbjrlog1.txt	./txt/cord-320238-qbjrlog1.txt