id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317435-4yuw7jo3	Zhou, Yadi	Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2	2020-03-16		.txt	text/plain	7742	388	39	Using network proximity analyses of drug targets and HCoV–host interactions in the human interactome, we prioritize 16 potential anti-HCoV repurposable drugs (e.g., melatonin, mercaptopurine, and sirolimus) that are further validated by enrichment analyses of drug-gene signatures and HCoV-induced transcriptomics data in human cell lines. The high druggability of HCoV-host interactome motivates us to develop a drug repurposing strategy by specifically targeting cellular proteins associated with HCoVs for potential treatment of 2019-nCoV/SARS-CoV-2. These network proximity analyses offer putative repurposable candidates for potential prevention and treatment of HCoVs. To further validate the 135 repurposable drugs against HCoVs, we first performed gene set enrichment analysis (GSEA) using transcriptome data of MERS-CoV and SARS-CoV infected host cells (see Methods).	./cache/cord-317435-4yuw7jo3.txt	./txt/cord-317435-4yuw7jo3.txt