id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312740-2ro2p77q	Babadaei, Mohammad Mahdi Nejadi	Development of remdesivir repositioning as a nucleotide analog against COVID-19 RNA dependent RNA polymerase	2020-05-20		.txt	text/plain	3820	217	50	A broad-spectrum of antiviral agents are being currently evaluated in clinical trials, and in this review, we specifically focus on the application of Remdesivir (RVD) as a potential anti-viral compound against Middle East respiratory syndrome (MERS) -CoV, SARS-CoV and SARS-CoV-2. First, we overview the general information about SARS-CoV-2, followed by application of RDV as a nucleotide analogue which can potentially inhibits RNA-dependent RNA polymerase of COVs. Afterwards, we discussed the kinetics of SARSor MERS-CoV proliferation in animal models which is significantly different compared to that in humans. With Having a considerable number of people worldwide infected with COVID-19, scientists have identified a number of cases of broad-spectrum antiviral agents (BSAAs) that could serve as potential candidates for the treatment of the viral diseases (Andersen et al., 2020; Ianevski et al., 2018) . Corona virus SARS-CoV-2 disease COVID-19: Infection, prevention and clinical advances of the prospective chemical drug therapeutics	./cache/cord-312740-2ro2p77q.txt	./txt/cord-312740-2ro2p77q.txt