id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309898-sju15hev	Hu, Yiwen	Comparative analysis of nanomechanical features of coronavirus spike proteins and correlation with lethality and infection rate	2020-11-02		.txt	text/plain	4295	219	50	The key result of our work is that both, the overall flexibility of upward RBD and the mobility ratio of RBDs in different conformations, represent two significant factors that show a positive scaling with virus lethality and an inverse correlation with the infection rate. Figure 2 depicts data that shows that the lowest-frequency normal modes of MERS-CoV, SARS-CoV and SARS-CoV-2 spike proteins are all associated with a swing motion of upward receptor-binding domain (RBD) to different extents. Figure 4 provides a correlation diagram for MERS-CoV, SARS-CoV and SARS-CoV-2 spike protein, where the overall flexibility of upward RBD is evaluated by the average fluctuation of open-state RBD and the mobility ratio is quantified as the ratio of maximum fluctuations over upward and downward RBDs. The data shows that both factors have positive correlation with case fatality rate and inverse relationship with the virus infectivity.	./cache/cord-309898-sju15hev.txt	./txt/cord-309898-sju15hev.txt