id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-307853-m1q1sjr4	Majumder, Satyabrata	Exploring the intrinsic dynamics of SARS-CoV-2, SARS-CoV and MERS-CoV spike glycoprotein through normal mode analysis using anisotropic network model	2020-10-16		.txt	text/plain	3048	176	57	title: Exploring the intrinsic dynamics of SARS-CoV-2, SARS-CoV and MERS-CoV spike glycoprotein through normal mode analysis using anisotropic network model In this study we have examined the intrinsic dynamics of the prefusion, lying state of trimeric S protein of these viruses through Normal Mode Analysis using Anisotropic Network Model. MERS-CoV spike shows unique dynamical motion compared to the other two S protein indicated by low RMSIP, spectral overlap and cosine correlation value. A detailed study to explore the intrinsic dynamical motion of the prefusion lying state spike protein trimer is needed for proper understanding of its function from conformation perspective. RMSIP computes quantitative comparison value between the sets of normal modes and expressed as: Structural alignments of the models were done using PyMol. We have computed the eigenvalues of first hundred non-zero normal modes of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike (S) proteins in the lying state ( Fig. 1 ).	./cache/cord-307853-m1q1sjr4.txt	./txt/cord-307853-m1q1sjr4.txt