id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-307109-nz8qvuw6	Martinez, Miguel Angel	Compounds with Therapeutic Potential against Novel Respiratory 2019 Coronavirus	2020-04-21		.txt	text/plain	3758	201	42	The previous epidemics of infections by high-morbidity human coronaviruses, such as SARS-CoV in 2003 and the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, prompted the characterization of compounds that could be potentially active against the currently emerging novel coronavirus, SARS-CoV-2. In addition, a combination of the human immunodeficiency virus type 1 (HIV-1) protease inhibitors lopinavir/ritonavir and interferon beta (LPV/RTV–IFN-β) was shown to be effective in patients infected with SARS-CoV. To predict new zoonotic coronavirus jumps across species and to understand the rate of virus spread among people, it is crucial to determine whether SARS-CoV-2 is mutating to improve its binding to human receptors for infection. Clinical observations in animals and humans showed that MERS-CoV infections were mediated by both virus replication and host inflammatory responses. However, therapeutic treatment with human monoclonal antibodies did not protect against the severe disease or the loss of lung function induced by MERS-CoV in animal models (20) .	./cache/cord-307109-nz8qvuw6.txt	./txt/cord-307109-nz8qvuw6.txt