id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-307067-cpc1yefj	van Doremalen, Neeltje	A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques	2020-06-10		.txt	text/plain	6244	329	50	For Middle East respiratory syndrome coronavirus (MERS-CoV), we show that rhesus macaques seroconverted rapidly after a single intramuscular vaccination with ChAdOx1 MERS. A prime-boost regimen of ChAdOx1 MERS boosted antibody titers, and viral replication was completely absent from the respiratory tract tissue of these rhesus macaques. Viral load was higher for lower respiratory tract tissue obtained from animals vaccinated with ChAdOx1 GFP (n = 6) than from animals receiving a prime-only (n = 6) or a prime-boost regimen of ChAdOx1 MERS (n = 2) (Fig. 4B ). Notably, antigenic differences have been reported between S proteins from the Middle East and Africa (8), potentially affecting the efficacy of a vaccine based In conclusion, we show that a single vaccination with ChAdOx1 MERS results in protection against disease progression and virus replication associated with MERS-CoV challenge in the rhesus macaque, and a prime-boost regimen reduced viral replication further.	./cache/cord-307067-cpc1yefj.txt	./txt/cord-307067-cpc1yefj.txt