id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305745-9lngdjow	Solnier, Julia	Flavonoids: A complementary approach to conventional therapy of COVID-19?	2020-09-18		.txt	text/plain	9494	469	48	Chalcones isolated from Angelica keiskei were shown to inhibit both SARS-CoV proteases PLpro and 3CLpro in enzymatic, FRET-based (Table 2) and molecular docking studies (Park et al. As Table 2 demonstrates, the compounds showed generally higher inhibitory potential against SARS-CoV PLpro than when tested against the other viral proteases using fluorogenic methods, which is likely related to genomic variations in the single amino acid sequences. In particular, herbacetin, quercetin and isobavachalcone (Fig. 3) were identified as promising antiviral leads against SARS-and MERS-CoV based on their broad-spectrum activity against the viral proteases 3CL and PL of both CoVs, the number of relevant literature data, and the availability of the compounds from different plant sources. However, despite some promising inhibitory activities of flavonoids against SARS-and MERS-CoV in vitro, none of these compounds have been tested in vivo using animal and/or human cell models.	./cache/cord-305745-9lngdjow.txt	./txt/cord-305745-9lngdjow.txt