id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305175-1wg0wodr	Dolzhikova, I. V.	Preclinical Studies of Immunogenity, Protectivity, and Safety of the Combined Vector Vaccine for Prevention of the Middle East Respiratory Syndrome	2020		.txt	text/plain	4488	198	44	Studies of its immunogenicity have shown that vaccination of animals (mice and primates) induces a robust humoral immune response that lasts for at least six months. A study of the vaccine protectivity conducted in a model of transgenic mice carrying the human DPP4 receptor gene showed that our vaccination protected 100% of the animals from the lethal infection caused by the MERS-CoV virus (MERS-CoV EMC/2012, 100LD(50) per mouse). For this Studies of the immunogenicity of the combined vector vaccine revealed the induction of long-term humoral immunity in mice, while the mean titer of glycoprotein-specific antibodies equaled 1 : 121,775 two weeks after vaccination at a dose of 10 7 v.p. per mouse. [13] , immunization of transgenic mice carrying the human DPP4 receptor gene with a ChAdOx1 MERS vaccine at a dose 10 8 v.p. per mouse was shown to protect 100% of the animals from a lethal infection with MERS-CoV.	./cache/cord-305175-1wg0wodr.txt	./txt/cord-305175-1wg0wodr.txt