id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305134-s7h6bpof	Mackman, Nigel	Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses	2020-07-13		.txt	text/plain	6412	443	41	It is likely that multiple systems contribute to thrombosis in COVID-19 patients, such as activation of coagulation, platelet activation, hypofibrinolysis, endothelial cell dysfunction, inflammation, neutrophil extracellular traps, and complement. 60, 82 Taken together, these results indicate that most COVID-19 patients have an activated coagulation system that is associated with increased levels of d-dimer; however, it is unlike classic DIC since there is little change in PT and the thrombocytopenia is generally mild. [95] [96] [97] [98] [99] There is clear evidence for activation of different cell types, such as lung epithelial cells, macrophages, neutrophils, endothelial cells, and platelets, as well as different systems, such as coagulation, inflammation, and complement, in the lungs of COVID-19 patients (Figure) . We found that plasma levels of extracellular vesicle TF activity were increased in severe influenza virus patients and were associated with mortality. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infects lung epithelial cells and endothelial cells (ECs), which leads to the recruitment of a variety of immune cells, such as macrophages and neutrophils.	./cache/cord-305134-s7h6bpof.txt	./txt/cord-305134-s7h6bpof.txt