id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-301016-9t7v7ipt	Forni, Diego	The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses	2015-09-25		.txt	text/plain	5087	247	46	We determined that different residues at position 1020 establish distinct interand intra-helical interactions and affect the stability of the six-helix bundle formed by the HRs. A similar effect on stability was observed for a nearby mutation (T1015N) that increases MERS-CoV infection efficiency in vitro. Data herein indicate that the heptad repeat region was a major target of adaptive evolution in MERS-CoV-related viruses; these results are relevant for the design of fusion inhibitor peptides with antiviral function. Motivated by the notion that evolutionary analyses can provide information on the molecular events that underlie host shifts and, more generally, host-pathogen interactions 19 , we investigated the evolutionary history of S proteins in MERS-CoV and related betaCoVs. Specifically, we aimed to determine whether natural selection drove the evolution of specific regions and sites that may contribute to variation in host range or replication efficiency.	./cache/cord-301016-9t7v7ipt.txt	./txt/cord-301016-9t7v7ipt.txt