id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293938-40zyv1h8	Jonsdottir, Hulda R.	Coronaviruses and the human airway: a universal system for virus-host interaction studies	2016-02-06		.txt	text/plain	5533	288	41	The emergence of both Severe Acute Respiratory Syndrome and Middle East Respiratory syndrome CoVs as well as the yearly circulation of four common CoVs highlights the importance of elucidating the different mechanisms employed by these viruses to evade the host immune response, determine their tropism and identify antiviral compounds. Tracheobronchial HAE cultures recapitulate the primary entry point of human respiratory viruses while the alveolar model allows for elucidation of mechanisms involved in viral infection and pathogenesis in the alveoli. Given the documented history of coronaviruses overcoming the species barrier and causing severe disease in humans, it is important to investigate the zoonotic potential of close evolutionary relatives of common HCoVs in a culture model that recapitulates the aspects of the human airway, e.g. morphology and receptor distribution. The establishment of transgenic animal models for human disease is attainable when either the virus receptor has been identified, which is not the case for all HCoVs, or when viruses can be adapted to a different host.	./cache/cord-293938-40zyv1h8.txt	./txt/cord-293938-40zyv1h8.txt