id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274122-n9jnu2ah	Mielech, Anna M.	MERS-CoV papain-like protease has deISGylating and deubiquitinating activities	2014-02-01		.txt	text/plain	4845	242	51	Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes with protease activity to process the viral replicase polyprotein and deubiquitinating (DUB)/deISGylating activity, which is hypothesized to modify the innate immune response to infection. Further, we compared the ability of MERS-CoV PLpro and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) PLpro to block innate immune signaling of proinflammatory cytokines. In this study, we demonstrate the deISGylating and deubiquitinating (DUB) activities of the papain-like protease from MERS-CoV, and provide new information on the potential role of coronavirus protease/DUBs to inhibit the innate immune response. Our results suggest that PLpro might contribute to the modulation of innate immune responses upon SARS-CoV and MERS-CoV infection, however, the exact mechanism and the role of coronavirus PLPs and their associated DUB and deISGylating activities in these processes remains to be determined.	./cache/cord-274122-n9jnu2ah.txt	./txt/cord-274122-n9jnu2ah.txt