id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270077-mfl0iagr	Chefer, Svetlana	Modeling [(18)F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge	2015-11-16		.txt	text/plain	4480	225	52	We used [(18)F]-FDG-PET/CT to investigate the host response developing in nonhuman primates after MERS-CoV exposure and applied kinetic modeling to monitor the influx rate constant (K(i)) in responsive lymphoid tissue. The [ 18 F]-FDG mean K i in bone marrow prior to MERS-CoV exposure was five-fold higher (0.03 ± 0.006 SD) compared to that observed in the LNs but did not follow the pattern of LN changes observed after virus challenge (Fig. 3b) . We monitored 18 F-FDG uptake primarily in lymphoid tissues at different locations in response to aerosol MERS-CoV challenge in NHPs. A group of mediastinal LNs showed a specific pattern of changes in K i up to 29 days post-virus exposure that correlates to K i changes in axillary lymph nodes. This study extends the use of kinetic modeling of [ 18 F]-FDG uptake during lung inflammation to host immune response after MERS-CoV exposure in rhesus macaques.	./cache/cord-270077-mfl0iagr.txt	./txt/cord-270077-mfl0iagr.txt