id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261533-73721b24	Mok, Chris Ka Pun	T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: an observational cohort study	2020-10-06		.txt	text/plain	4827	224	51	We therefore aimed to test peripheral blood mononuclear cells (PBMC) in workers from an abattoir in Kano, Nigeria, for MERS-CoV-specific T-cell responses to understand if the dromedary-exposed individuals in Africa have been infected by MERS-CoV. Evidence before this study Middle East respiratory syndrome coronavirus (MERS-CoV) is recognised as one of eight emerging pathogens of greatest threat to global public health, and dromedary camels are the source of human zoonotic infection. Because there was evidence that serological assays for MERS-CoV had suboptimal sensitivity for past infection and because we had previous data showing that T-cell assays for MERS-CoV are specific and potentially more sensitive than antibody detection, we investigated T-cell responses in dromedary-exposed abattoir workers and controls in Nigeria. 61 (53%) of the 115 participants had PBMCs available for additional testing for four endemic human coronaviruses (229E, HKU1, NL63, and OC43), including 18 dromedary-exposed workers positive and ten negative for a MERS-CoV T-cell response and 33 from the negative control groups who were all MERS-CoV T-cell negative.	./cache/cord-261533-73721b24.txt	./txt/cord-261533-73721b24.txt