id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-259347-3acsko74	Cheng, Qi	Infectivity of human coronavirus in the brain	2020-05-28		.txt	text/plain	3981	185	42	A new strain of human coronaviruses (hCoVs), Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been identified to be responsible for the current outbreak of the coronavirus disease 2019 (COVID-19). Data from multiple hACE2 transgenic mouse models has revealed that SARS-CoV detection in the brain is significantly delayed compared to that within the lung, consistent with the initial establishment of infection within the respiratory system before dissemination to the CNS [21À23]. In addition, the detection of SARS-CoV in CSF of patients with neurological manifestation has also provided direct evidence for the neuroinvasion and neurovirulence of hCoVs. However, the role of the virus in the process of the disease in acute phase as well as in the long term still remains elusive. Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor	./cache/cord-259347-3acsko74.txt	./txt/cord-259347-3acsko74.txt