id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255378-qgklt8wa	Huang, Yi-Ping	NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV)	2016-03-18		.txt	text/plain	1262	83	58	title: NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV) The newly emerging human pathogen, Middle East respiratory syndrome coronavirus (MERS-CoV), contains a macro domain in the highly conserved N-terminal region of non-structural protein 3. In this study we report the preliminary structural analysis through solution NMR spectroscopy of the MERS-CoV macro domain. The near complete NMR assignments of MERS-CoV macro domain provide the basis for subsequent structural and biochemical investigation in the context of protein function. Secondary structure elements of MERS-CoV macro domain were identified by calculating the chemical shift deviations of the Ca(DdCa) and Cb(DdCb) from the random coil values and was corroborated by analysis of the chemical shift data using the program TALOS? Six helices and seven b-strands could be deduced for MERS-CoV moacro domain protein based on the secondary chemical shift analysis, which results in residues 21-27, 47-54.	./cache/cord-255378-qgklt8wa.txt	./txt/cord-255378-qgklt8wa.txt