id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317430-uvx8si42	Chen, Yaping	Emerging Roles of 1D Vertical Nanostructures in Orchestrating Immune Cell Functions	2020-08-26		.txt	text/plain	11481	673	39	[6] In particular, SiNW arrays demonstrated high efficiency (>90%) in transfecting exogenous genetic materials into primary immune cells-which are notoriously hard to transfect-while maintaining high viability and immunological competence; [27, 28, 36] siRNAs were transfected via SiNWs into primary B cells and CD4 + T cells to knock down predicted target genes, facilitating discovery of essential signaling pathways and genetic regulatory circuits for immune cell activation and differentiation; [27, 28] SiNWs were used to administer a small-molecule inhibitor of the enzyme Polo-like kinase (Plk) into bone-marrow derived dendritic cells (BMDCs), confirming the essential role of Plk2 and Plk4 in regulating antiviral gene expression in these cell; [37] by using vertical carbon nanosyringe arrays (CNSAs) under applied centrifugal g-force, pEGFP plasmids were transfected www.advmat.de www.advancedsciencenews.com into primary lymphocytes with significantly higher efficiency than conventional Lipofectamine 2000-mediated method.	./cache/cord-317430-uvx8si42.txt	./txt/cord-317430-uvx8si42.txt